JPH0248515A - Hair tonic - Google Patents
Hair tonicInfo
- Publication number
- JPH0248515A JPH0248515A JP63198886A JP19888688A JPH0248515A JP H0248515 A JPH0248515 A JP H0248515A JP 63198886 A JP63198886 A JP 63198886A JP 19888688 A JP19888688 A JP 19888688A JP H0248515 A JPH0248515 A JP H0248515A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- surfactants
- extracts
- ethanol
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000001256 tonic effect Effects 0.000 title abstract description 8
- 239000000284 extract Substances 0.000 claims abstract description 39
- 229940079593 drug Drugs 0.000 claims abstract description 20
- 239000003814 drug Substances 0.000 claims abstract description 20
- 239000004094 surface-active agent Substances 0.000 claims abstract description 19
- 240000001008 Dimocarpus longan Species 0.000 claims abstract description 10
- 244000097577 Rhus javanica Species 0.000 claims abstract 5
- 235000010889 Rhus javanica Nutrition 0.000 claims abstract 5
- 239000000126 substance Substances 0.000 claims abstract 3
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims description 13
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims description 13
- 235000009685 Crataegus X maligna Nutrition 0.000 claims description 13
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims description 13
- 235000009486 Crataegus bullatus Nutrition 0.000 claims description 13
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims description 13
- 235000009682 Crataegus limnophila Nutrition 0.000 claims description 13
- 235000004423 Crataegus monogyna Nutrition 0.000 claims description 13
- 235000002313 Crataegus paludosa Nutrition 0.000 claims description 13
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims description 13
- 239000003945 anionic surfactant Substances 0.000 claims description 11
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 10
- 235000000235 Euphoria longan Nutrition 0.000 claims description 9
- 239000002280 amphoteric surfactant Substances 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 150000001412 amines Chemical class 0.000 claims description 6
- 241000411851 herbal medicine Species 0.000 claims description 6
- 241001092040 Crataegus Species 0.000 claims 4
- 244000153234 Hibiscus abelmoschus Species 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 abstract description 5
- 238000002156 mixing Methods 0.000 abstract description 5
- 239000000203 mixture Substances 0.000 abstract description 4
- 239000006071 cream Substances 0.000 abstract description 3
- 239000002453 shampoo Substances 0.000 abstract description 3
- 239000000443 aerosol Substances 0.000 abstract description 2
- 238000009472 formulation Methods 0.000 abstract description 2
- 239000000499 gel Substances 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 abstract description 2
- 239000002674 ointment Substances 0.000 abstract description 2
- 230000002265 prevention Effects 0.000 abstract description 2
- 230000001737 promoting effect Effects 0.000 abstract description 2
- 210000004761 scalp Anatomy 0.000 abstract description 2
- 241000206501 Actaea <angiosperm> Species 0.000 abstract 1
- 240000007185 Albizia julibrissin Species 0.000 abstract 1
- 235000011468 Albizia julibrissin Nutrition 0.000 abstract 1
- 241000748223 Alisma Species 0.000 abstract 1
- 235000000525 Dimocarpus longan Nutrition 0.000 abstract 1
- 244000287839 Vaccinium bracteatum Species 0.000 abstract 1
- 235000005480 Vaccinium bracteatum Nutrition 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 230000035617 depilation Effects 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000006210 lotion Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 81
- -1 For example Substances 0.000 description 32
- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical compound CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 description 30
- 239000000469 ethanolic extract Substances 0.000 description 24
- 230000000694 effects Effects 0.000 description 16
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 15
- 230000003779 hair growth Effects 0.000 description 15
- 239000000401 methanolic extract Substances 0.000 description 14
- 201000004384 Alopecia Diseases 0.000 description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 10
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 9
- 240000000171 Crataegus monogyna Species 0.000 description 9
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 9
- 229960003237 betaine Drugs 0.000 description 9
- 235000014113 dietary fatty acids Nutrition 0.000 description 9
- 229930195729 fatty acid Natural products 0.000 description 9
- 239000000194 fatty acid Substances 0.000 description 9
- 230000003676 hair loss Effects 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 8
- DVEKCXOJTLDBFE-UHFFFAOYSA-N n-dodecyl-n,n-dimethylglycinate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC([O-])=O DVEKCXOJTLDBFE-UHFFFAOYSA-N 0.000 description 8
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 7
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 7
- 150000004665 fatty acids Chemical class 0.000 description 7
- 208000024963 hair loss Diseases 0.000 description 7
- 208000001840 Dandruff Diseases 0.000 description 6
- 239000002736 nonionic surfactant Substances 0.000 description 6
- 108090000854 Oxidoreductases Proteins 0.000 description 5
- 102000004316 Oxidoreductases Human genes 0.000 description 5
- 240000004371 Panax ginseng Species 0.000 description 5
- 150000001298 alcohols Chemical class 0.000 description 5
- 235000008434 ginseng Nutrition 0.000 description 5
- OZYPPHLDZUUCCI-UHFFFAOYSA-N n-(6-bromopyridin-2-yl)-2,2-dimethylpropanamide Chemical compound CC(C)(C)C(=O)NC1=CC=CC(Br)=N1 OZYPPHLDZUUCCI-UHFFFAOYSA-N 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 4
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 4
- 235000003140 Panax quinquefolius Nutrition 0.000 description 4
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 4
- 240000001417 Vigna umbellata Species 0.000 description 4
- 235000011453 Vigna umbellata Nutrition 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 230000003660 hair regeneration Effects 0.000 description 4
- 125000001183 hydrocarbyl group Chemical group 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 235000021317 phosphate Nutrition 0.000 description 4
- 229920006395 saturated elastomer Polymers 0.000 description 4
- 229930195734 saturated hydrocarbon Natural products 0.000 description 4
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 4
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 3
- 240000007124 Brassica oleracea Species 0.000 description 3
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 description 3
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 3
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 241001125048 Sardina Species 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229940055577 oleyl alcohol Drugs 0.000 description 3
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 235000019512 sardine Nutrition 0.000 description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 3
- 150000005846 sugar alcohols Polymers 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- PSBDWGZCVUAZQS-UHFFFAOYSA-N (dimethylsulfonio)acetate Chemical compound C[S+](C)CC([O-])=O PSBDWGZCVUAZQS-UHFFFAOYSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 description 2
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- NKFNBVMJTSYZDV-UHFFFAOYSA-N 2-[dodecyl(2-hydroxyethyl)amino]ethanol Chemical compound CCCCCCCCCCCCN(CCO)CCO NKFNBVMJTSYZDV-UHFFFAOYSA-N 0.000 description 2
- 108010029908 3-oxo-5-alpha-steroid 4-dehydrogenase Proteins 0.000 description 2
- 102000001779 3-oxo-5-alpha-steroid 4-dehydrogenase Human genes 0.000 description 2
- 240000004160 Capsicum annuum Species 0.000 description 2
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 description 2
- 235000007862 Capsicum baccatum Nutrition 0.000 description 2
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical class NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 description 2
- 244000060011 Cocos nucifera Species 0.000 description 2
- 235000013162 Cocos nucifera Nutrition 0.000 description 2
- 244000018436 Coriandrum sativum Species 0.000 description 2
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- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
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- KVYGGMBOZFWZBQ-UHFFFAOYSA-N benzyl nicotinate Chemical compound C=1C=CN=CC=1C(=O)OCC1=CC=CC=C1 KVYGGMBOZFWZBQ-UHFFFAOYSA-N 0.000 description 2
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- 150000002148 esters Chemical class 0.000 description 2
- 235000008397 ginger Nutrition 0.000 description 2
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- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
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- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
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- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- JDSVWTAJRNTSSL-UHFFFAOYSA-M sodium;dodecyl hydrogen phosphate Chemical compound [Na+].CCCCCCCCCCCCOP(O)([O-])=O JDSVWTAJRNTSSL-UHFFFAOYSA-M 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
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- 229960003604 testosterone Drugs 0.000 description 2
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- YIWGJFPJRAEKMK-UHFFFAOYSA-N 1-(2H-benzotriazol-5-yl)-3-methyl-8-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carbonyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione Chemical compound CN1C(=O)N(c2ccc3n[nH]nc3c2)C2(CCN(CC2)C(=O)c2cnc(NCc3cccc(OC(F)(F)F)c3)nc2)C1=O YIWGJFPJRAEKMK-UHFFFAOYSA-N 0.000 description 1
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- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 241000234314 Zingiber Species 0.000 description 1
- 241000963384 Zingiber mioga Species 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 125000002877 alkyl aryl group Chemical group 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 1
- 230000001548 androgenic effect Effects 0.000 description 1
- 229940030486 androgens Drugs 0.000 description 1
- 229960003473 androstanolone Drugs 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 229940069765 bean extract Drugs 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- 229950004580 benzyl nicotinate Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- JFIOVJDNOJYLKP-UHFFFAOYSA-N bithionol Chemical compound OC1=C(Cl)C=C(Cl)C=C1SC1=CC(Cl)=CC(Cl)=C1O JFIOVJDNOJYLKP-UHFFFAOYSA-N 0.000 description 1
- 229960002326 bithionol Drugs 0.000 description 1
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- RZMKWKZIJJNSLQ-UHFFFAOYSA-M carpronium chloride Chemical compound [Cl-].COC(=O)CCC[N+](C)(C)C RZMKWKZIJJNSLQ-UHFFFAOYSA-M 0.000 description 1
- 229950003631 carpronium chloride Drugs 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 229930182912 cyclosporin Natural products 0.000 description 1
- 229960004042 diazoxide Drugs 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- YVZRXRJDBYHNMK-UHFFFAOYSA-N dodecyl 2-aminoacetate Chemical compound CCCCCCCCCCCCOC(=O)CN YVZRXRJDBYHNMK-UHFFFAOYSA-N 0.000 description 1
- YRIUSKIDOIARQF-UHFFFAOYSA-N dodecyl benzenesulfonate Chemical compound CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 YRIUSKIDOIARQF-UHFFFAOYSA-N 0.000 description 1
- 229940071161 dodecylbenzenesulfonate Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 238000002481 ethanol extraction Methods 0.000 description 1
- 229960002568 ethinylestradiol Drugs 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 1
- 229960004068 hexachlorophene Drugs 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 150000004693 imidazolium salts Chemical class 0.000 description 1
- 229940074928 isopropyl myristate Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229960003632 minoxidil Drugs 0.000 description 1
- IBOBFGGLRNWLIL-UHFFFAOYSA-N n,n-dimethylhexadecan-1-amine oxide Chemical compound CCCCCCCCCCCCCCCC[N+](C)(C)[O-] IBOBFGGLRNWLIL-UHFFFAOYSA-N 0.000 description 1
- SFBHPFQSSDCYSL-UHFFFAOYSA-N n,n-dimethyltetradecan-1-amine Chemical compound CCCCCCCCCCCCCCN(C)C SFBHPFQSSDCYSL-UHFFFAOYSA-N 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- BJLVKAGPBSJBSJ-UHFFFAOYSA-N n-dodecyl-n-methyldodecan-1-amine oxide Chemical compound CCCCCCCCCCCC[N+](C)([O-])CCCCCCCCCCCC BJLVKAGPBSJBSJ-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229940070687 psyllium Drugs 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 150000003431 steroids Chemical group 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 125000001273 sulfonato group Chemical class [O-]S(*)(=O)=O 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 229960001325 triclocarban Drugs 0.000 description 1
- 239000006097 ultraviolet radiation absorber Substances 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9755—Gymnosperms [Coniferophyta]
- A61K8/9767—Pinaceae [Pine family], e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
[産業上の利用分野]
本発明は、新規にして、かつ安全なる生薬抽出物または
、生薬抽出物と界面活性剤とを含有することにより、脱
毛防止、発毛、育毛などを促進する効果に優れた養毛料
に関するものである。Detailed Description of the Invention [Industrial Application Field] The present invention contains novel and safe crude drug extracts or crude drug extracts and surfactants to prevent hair loss, hair growth, The present invention relates to a hair nourishing agent that is highly effective in promoting hair growth.
[従来の技術]
従来より、男性型の禿頭、粗毛症、脂漏などの生理学上
の徴候は、代謝系に男性ホルモンが過剰に蓄積されるこ
とに起因する男性ホルモン刺激の増大に基づいているこ
とが知られている。また最近、毛根、皮脂腺をはじめい
くつかの器官において男性ホルモン活性の本体は、5α
−ジヒドロテストステロン(以下、5α−DHTと略す
。)であり、これは標的器官においてテストステロンが
テストステロン−5α−レダクターゼ(以下、レダクタ
ーゼと略す。)により還元されることによって生成する
ことが周知になっている。[Prior art] Physiological symptoms such as male-pattern baldness, baldness, and seborrhea have traditionally been based on increased stimulation of androgen hormones caused by excessive accumulation of androgenic hormones in the metabolic system. It is known. Recently, it has been discovered that the main body of male hormone activity in several organs including hair roots and sebaceous glands is 5α.
- Dihydrotestosterone (hereinafter abbreviated as 5α-DHT), which is well known to be produced when testosterone is reduced by testosterone-5α-reductase (hereinafter abbreviated as reductase) in target organs. There is.
そのため、男性ホルモン刺激の増大に起因する男性型の
禿頭、粗毛症、脂謡などの徴候は、レダクターゼを阻害
することにより低減あるいは防止することができると考
えられ、レダクターゼを特異的に阻害するいくつかの阻
害剤が見出され、また合成されてきた。しかし、今まで
に新規に合成された阻害剤は、ステロイド構造あるいは
ステロイド類似構造を持っており、好ましくないホルモ
ン様作用を多少なりとも有しているという欠点があった
。Therefore, it is thought that symptoms such as male-pattern baldness, baldness, and oiliness caused by increased stimulation of androgens can be reduced or prevented by inhibiting reductase. Such inhibitors have been discovered and synthesized. However, the newly synthesized inhibitors to date have a steroid structure or a steroid-like structure, and have the drawback of having some degree of undesirable hormone-like action.
[発明が解決しようとする課題]
本発明者等は脱毛防止、発毛、育毛等に有効で、安全性
に優れた天然由来の薬剤を鋭意検討した結果、特定の生
薬抽出物の一種又は二種以上、またはこれら特定の生薬
抽出物の一種又は二種以上と特定の界面活性剤とがこの
課題を解決しうろことを見出し、本発明を完成するに至
った。[Problems to be Solved by the Invention] As a result of intensive research into naturally-derived drugs that are effective for hair loss prevention, hair growth, hair growth, etc. and have excellent safety, the present inventors have found that one or two specific crude drug extracts have been developed. The present inventors have discovered that this problem can be solved by using one or more of these specific herbal medicine extracts, or one or more of these specific crude drug extracts, and a specific surfactant, and have completed the present invention.
[課題を解決するための手段1
すなわち、請求項1記載の発明は、ヌルデ、ネムノキ、
サンザシ、ショウマ、センポウ、サソウ、タクシャ、テ
ンマ、トウジン、ドケイヒ、ナンショクシャシャンボ、
リュウガンからなる群から選ばれる生薬抽出物の一種又
は二種以上を含有してなる養毛料である。[Means for solving the problem 1 That is, the invention according to claim 1 is directed to
Hawthorn, Shoma, Senpou, Sasou, Takusha, Tenma, Toujin, Dokeihi, Nanshokushashanbo,
This hair nourishing agent contains one or more crude drug extracts selected from the group consisting of longan.
請求項2記載の発明は、請求項1記載の生薬の抽出物の
一種又は二種以上と、アニオン性界面活性剤の一種又は
二種以上と、アニオン界面活性剤以外で分子内に窒素原
子を有する界面活性剤の一種又は二種以上とを含有する
ことを特徴とする養毛科である。The invention according to claim 2 comprises one or more extracts of the crude drug according to claim 1, one or more anionic surfactants, and a nitrogen atom in the molecule other than the anionic surfactant. It is a hair nourishing family characterized by containing one or more types of surfactants.
請求項3記載の発明は、請求項1記載の生薬の抽出物の
一種又は二種以上と、両性界面活性剤と半極性界面活性
剤の一種または二種以上と、分子内に窒素原子を有する
非イオン界面活性剤の一種または二種以上とを含有する
ことを特徴とする養毛科である。The invention according to claim 3 is characterized in that one or more extracts of the crude drug according to claim 1, one or more amphoteric surfactants and semipolar surfactants, and a nitrogen atom in the molecule. It is a hair-nourishing product characterized by containing one or more nonionic surfactants.
請求項4記載の発明は、請求項1記載の生薬の抽出物の
一種又は二種以上と、アミンオキシドとを含有すること
を特(敦とする養毛科である。The invention according to claim 4 is a trichophyte containing one or more extracts of the crude drug according to claim 1 and an amine oxide.
以下、本発明の構成について詳述する。Hereinafter, the configuration of the present invention will be explained in detail.
本発明で用いられる生薬抽出物としては、生薬を溶媒、
例えば、熱水やメタノール、エタノール等の低級アルコ
ールあるいは含水低級アルコールあるいはプロピレング
リコール、1−3ブチレングリコール等の多価アルコー
ルあるいは含水多価アルコール等の含水アルコール等で
抽出して得られる抽出エキスや、その抽出エキスを濃縮
乾燥して得られる抽出物等が挙げられる。本発明におけ
る生薬抽出物の配合量は、養毛料金量中、乾燥物として
0.005〜10重景%、好重量くは0.01〜5重量
%である。0.005重景重量満であると、本発明でい
う効果が十分に発揮されず、好ましくない。As the crude drug extract used in the present invention, the crude drug is used as a solvent,
For example, extracts obtained by extraction with hot water, lower alcohols such as methanol, ethanol, hydrous lower alcohols, polyhydric alcohols such as propylene glycol, 1-3 butylene glycol, or hydrous alcohols such as hydrous polyhydric alcohols, Examples include extracts obtained by concentrating and drying the extracted extract. The blending amount of the herbal medicine extract in the present invention is 0.005 to 10% by weight, preferably 0.01 to 5% by weight as dry matter in the amount of hair nourishing material. If the weight is less than 0.005, the effects of the present invention will not be sufficiently exhibited, which is not preferable.
請求項1記載のアニオン性界面活性剤としては、カルボ
ン酸基、スルホン酸基、硫酸エステル基、リン酸エステ
ル基を分子内に一種または二種以上有するアニオン性界
面活性剤が挙げられる。カルボン酸基を有するものとし
ては脂肪酸セッケン、エーテルカルボン酸およびその塩
、アミノ酸と脂肪酸の縮合物等のカルボン酸塩等を、又
、スルホン酸塩を有するものとしては、アルキルスル示
ン酸塩、スルホコハク酸、エステルスルホン酸塩、アル
キルアリル及びアルキルナフタレンスルホン酸塩、N−
アシルスルホン酸塩、ホルマリン縮合系スルホン酸塩等
を、硫酸エステル基を有するものとしては、硫酸化油、
エステル硫酸塩、アルキル硫酸塩、エーテル硫酸塩、ア
ルキルアリルエーテル硫酸塩、アミド硫酸塩等を、リン
酸エステル基を有するものとしては、アルキルリン酸塩
、アミドリン酸塩、エーテルリン酸塩、アルキルアリル
エーテルリン酸塩等を挙げることができる。これらの中
から一種または二種以上が任意に選択される。The anionic surfactant according to claim 1 includes anionic surfactants having one or more types of carboxylic acid group, sulfonic acid group, sulfuric acid ester group, and phosphoric acid ester group in the molecule. Those having a carboxylic acid group include fatty acid soaps, ether carboxylic acids and their salts, carboxylates such as amino acid and fatty acid condensates, and those having a sulfonate include alkylsulfinates, Sulfosuccinic acid, ester sulfonate, alkylaryl and alkylnaphthalene sulfonate, N-
Acyl sulfonates, formalin condensation sulfonates, etc. have sulfate ester groups, such as sulfated oils,
Ester sulfates, alkyl sulfates, ether sulfates, alkyl allyl ether sulfates, amide sulfates, etc., those having a phosphoric acid ester group include alkyl phosphates, amide phosphates, ether phosphates, alkylaryl sulfates, etc. Ether phosphates and the like can be mentioned. One or more types are arbitrarily selected from these.
請求項1記載のアニオン性界面活性剤以外で分子内に窒
素原子を有する界面活性剤としては、窒素原子を分子内
に有する両性界面活性剤、半極性界面活性剤、非イオン
性界面活性剤、カチオン性界面活性剤等を挙げることが
できる。両性界面活性剤としては、N、N−ジメチル−
N−ラウリルートカルボキシメチルアンモニウムベタイ
ン、H,N−ジメチル−N−オレイル−H−カルボキシ
メチルアンモニウムベタイン等のカルボキシベタイン、
2−ラウリルート力ルポキシエチルーN−ヒドロキシエ
チルイミダゾリニウムベタイン、2−ラウリル−N−カ
ルボキシメチル−N−ヒドロキシエチルイミダゾリニウ
ムベタイン等のイミダシリン誘導体、トヤシアルキルー
β−アミノプロピオン酸ソーダ塩、N−ヤシアルキル−
β−イミノジプロピオン酸−ジ−ソーダ塩等のアミノカ
ルボン酸塩、スルホベタイン、アミノベタイン等が挙げ
られる。半極性界面活性剤としては、ジメチルラウリル
アミンオキシド、ビス−(2−ヒドロキシエチル)ラウ
リルアミンオキシド等が挙げられる。非イオン性界面活
性剤としては、脂肪酸アルカノールアミド、ポリオキシ
エチレン脂肪酸アミド、アルカノールアミンのエステル
、ポリオキシエチレンアルキルアミン等が挙げられる。Examples of surfactants having a nitrogen atom in the molecule other than the anionic surfactant according to claim 1 include amphoteric surfactants having a nitrogen atom in the molecule, semipolar surfactants, nonionic surfactants, Examples include cationic surfactants. As the amphoteric surfactant, N,N-dimethyl-
carboxybetaine such as N-lauryl root carboxymethyl ammonium betaine, H,N-dimethyl-N-oleyl-H-carboxymethyl ammonium betaine,
Imidacillin derivatives such as 2-lauryl-rupoxyethyl-N-hydroxyethylimidazolinium betaine, 2-lauryl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, coconut alkyl-β-aminopropionic acid sodium salt, N-coconut alkyl-
Examples include aminocarboxylic acid salts such as β-iminodipropionic acid di-soda salt, sulfobetaine, aminobetaine, and the like. Examples of the semipolar surfactant include dimethyl lauryl amine oxide, bis-(2-hydroxyethyl) lauryl amine oxide, and the like. Examples of the nonionic surfactant include fatty acid alkanolamide, polyoxyethylene fatty acid amide, alkanolamine ester, polyoxyethylene alkylamine, and the like.
カチオン性界面活性剤としては、脂肪酸アミン塩、アル
キル四級アンモニウム塩、芳香族四級アンモニウム塩、
ピーリジウム塩、イミダゾリウム塩等が挙げられる。こ
れらの中から一種又は二種以上が任意に選択される。Examples of cationic surfactants include fatty acid amine salts, alkyl quaternary ammonium salts, aromatic quaternary ammonium salts,
Examples include pyridium salts and imidazolium salts. One or more types are arbitrarily selected from these.
請求項2記載の両性界面活性剤としては、N、H−ジメ
チル−N−ラウリル−H−カルボキシメチルアンモニウ
ムベタイン、N、N−ジメチル−■−オレイルーN−カ
ルボキシメチルアンモニウムベタイン等のカルボキシベ
タイン、2−ラウリル−N−カルボキシエチル−N−ヒ
ドロキシエチルイミダゾリニウムベタイン、2−ラウリ
ル−H−力シボキシメチル−N−ヒドロキシエチルイミ
ダゾリニウムベタイン等のイミダシリン誘導体、トヤシ
アルキルーβ−アミノプロピオン酸ソーダ塩、N−ヤシ
アルキル−β−イミノジプロピオン酸−ジ−ソーダ塩等
のアミノカルボン酸塩、スルホベタイン、アミノベタイ
ン等が挙げられる。The amphoteric surfactant according to claim 2 includes carboxybetaine such as N,H-dimethyl-N-lauryl-H-carboxymethylammonium betaine, N,N-dimethyl-■-oleyl-N-carboxymethylammonium betaine, 2 -Imidacillin derivatives such as lauryl-N-carboxyethyl-N-hydroxyethylimidazolinium betaine, 2-lauryl-H-carboxymethyl-N-hydroxyethylimidazolinium betaine, toyasialkyl-β-aminopropionic acid sodium salt, N- Examples include aminocarboxylic acid salts such as coconut alkyl-β-iminodipropionic acid di-soda salt, sulfobetaine, aminobetaine, and the like.
請求項2記載の半極性界面活性剤としては、ジメチルラ
ウリルアミンオキシド、ビス−(2−ヒドロキシエチル
)ラウリルアミンオキシド等が挙げられる。Examples of the semipolar surfactant according to claim 2 include dimethyl lauryl amine oxide, bis-(2-hydroxyethyl) lauryl amine oxide, and the like.
請求項2記載の非イオン性界面活性剤としては、脂肪酸
アルカノールアミド、ポリオキシエチレン脂肪酸アミド
、アルカノールアミンのエステル、ポリオキシエチレン
アルキルアミン等が挙げられる。Examples of the nonionic surfactant according to claim 2 include fatty acid alkanolamide, polyoxyethylene fatty acid amide, alkanolamine ester, polyoxyethylene alkylamine, and the like.
請求項3記載のアミンオキシドとしては、下記一般式(
A)〜(C)のものが挙げられる。The amine oxide according to claim 3 has the following general formula (
Examples are A) to (C).
R2N→0
(A)
(式中R1、R2およびR3は炭素原子数1から24の
直鎖または分枝の飽和又は不飽和の炭化水素基を表わし
、R1、R2、R3のうち少なくとも1個は炭素原子数
8以上の直鎮または分枝の飽和又は不飽和の炭化水素基
を表わす。)
一般式(A)で表わされるアミンオキシドの具体例とし
ては、ジメチルラウリルアミンオキシド、ジメチルミリ
スチルアミンオキシド、ジメチルセチルアミンオキシド
、ジメチルステフリルアミンオキシド、ジメチルオレイ
ルアミンオキシド、ジメチルオレイルアミンオキシド、
メチルジラウリルアミンオキシドなどが挙げられる。R2N→0 (A) (wherein R1, R2, and R3 represent a straight chain or branched saturated or unsaturated hydrocarbon group having 1 to 24 carbon atoms, and at least one of R1, R2, and R3 is Represents a straight or branched saturated or unsaturated hydrocarbon group having 8 or more carbon atoms.) Specific examples of the amine oxide represented by the general formula (A) include dimethyl lauryl amine oxide, dimethyl myristyl amine oxide, Dimethylcetylamine oxide, dimethylstefurylamine oxide, dimethyloleylamine oxide, dimethyloleylamine oxide,
Examples include methyl dilaurylamine oxide.
CH2CR20H
R4N→0 (B)CH2
CR20H
(式中R4は炭素原子数8から24の直鎖または分枝の
飽和又は不飽和の炭化水素基を表わす。) R3
R5(QCH2CR2) n N→0(C)
H3
(式中R5は炭素原子数8から24の直鎖または分枝の
飽和又は不飽和の炭化水恋基を表わし、nは1から5の
整数を表わす。)
本発明においては、これらアミンオキシドの一種または
二種以上が任意に選択され、用いられる。CH2CR20H R4N→0 (B) CH2
CR20H (In the formula, R4 represents a straight chain or branched saturated or unsaturated hydrocarbon group having 8 to 24 carbon atoms.) R3 R5 (QCH2CR2) n N→0(C) H3 (In the formula, R5 is a carbon (Represents a straight chain or branched saturated or unsaturated hydrocarbon group having 8 to 24 atoms, and n represents an integer of 1 to 5.) In the present invention, one or more of these amine oxides arbitrarily selected and used.
請求項1記載のアニオン性界面活性剤と、アニオン性界
面活性剤以外で分子内に窒素原子を有する界面活性剤の
合計配合量は、養毛科全量中0.001〜10重量%が
好ましく、ざらに好ましくは0.01〜5重量%である
。また、アニオン性界面活性剤と、アニオン性界面活性
剤以外で分子内に窒素原子を有する界面活性剤との割合
は、分子比で20:1〜1:20が好ましく、ざらに好
士しくは10:l〜1:10である。The total blending amount of the anionic surfactant according to claim 1 and a surfactant other than the anionic surfactant having a nitrogen atom in the molecule is preferably 0.001 to 10% by weight based on the total amount of the trichophyte, The content is preferably 0.01 to 5% by weight. Further, the ratio of the anionic surfactant to the surfactant other than the anionic surfactant having a nitrogen atom in the molecule is preferably 20:1 to 1:20 in terms of molecular ratio, and more preferably The ratio is 10:1 to 1:10.
請求項2記載の両性界面活性剤と半極性界面活性剤の一
種または二種以上と、分子内に窒素原子を有する非イオ
ン性界面活性剤の一種または二種以上の合計配合量は、
養毛科全量中0.001〜10重量%が好ましく、さら
に好ましくは0.01〜5重量%である。また、両性界
面活性剤と半極性界面活性剤の一種または二種以上と、
分子内に窒素原子を有する非イオン性界面活性剤の一種
または二種以上との割合は、分子比で20=1〜1:2
0が好ましく、さらに好ましくは10:1〜1:10で
ある。The total blending amount of one or more amphoteric surfactants and semipolar surfactants according to claim 2 and one or more nonionic surfactants having a nitrogen atom in the molecule is:
The content is preferably 0.001 to 10% by weight, more preferably 0.01 to 5% by weight based on the total amount of hair growth. In addition, one or more types of amphoteric surfactants and semipolar surfactants,
The ratio of one or more nonionic surfactants having a nitrogen atom in the molecule is 20=1 to 1:2 in molecular ratio.
The ratio is preferably 0, more preferably 10:1 to 1:10.
請求項3記載のアミンオキシドの配合量は、養毛料金量
中の0.0001〜20重量%が好ましい。配合量が0
.0001重量%未満では十分な養毛効果が得られず、
20重量%を越えると製剤上または皮膚刺激の上からも
好すしくない。The amount of the amine oxide according to claim 3 is preferably 0.0001 to 20% by weight based on the amount of hair nourishing material. Blend amount is 0
.. If it is less than 0001% by weight, sufficient hair nourishing effect cannot be obtained,
If it exceeds 20% by weight, it is undesirable from the standpoint of formulation and skin irritation.
本発明に係る養毛料には、上記必須成分のほかに、通常
養毛科に用いられる汎用成分、例えばビタミンB6、ビ
タミンE及びその誘導体、ビオチン等のビタミン類、パ
ントテン酸及びその誘導体、グリチルレチン酸及びその
誘導体、ニコチン酸ベンジル等のニコチン酸エステル類
、サイクロスポリン類、塩化カルプロニウム、セファラ
ンチン、オギセンドロン、ジアゾキシド、ミノキシジル
、エチニルエストラジオールなどの発毛剤又は発毛助剤
、ヒノキチオール、ヘキサクロロフェン、フェノール、
ベンザルコニウムクロリド、セチルピリジニウムクロリ
ド、ウンデシレン酸、トリクロロカルバニリド及びビチ
オノールなどの抗菌剤、メントールなどの清涼剤、サリ
チル酸、亜鉛及びその誘導体、乳酸及びそのアルキルエ
ステルなどの薬剤、クエン酸等の有機酸類、アルギニン
等のアミノ酸類、オリーブ油、スクワラン、流動パラフ
ィン、イソプロピルミリステート、高級脂肪酸、高級ア
ルコールなどの油分、グリセリン、プロピレングリコー
ル等の多価アルコール、香料、酸化防止剤、紫外線吸収
剤、色素、エタノール、ベンジルアルコール、イソプロ
ピルアルコール等のアルコール類、水、保湿剤、増粘剤
などが本発明の効果を損なわない範囲で適宜配合するこ
とができる。In addition to the above-mentioned essential ingredients, the hair nourishment according to the present invention includes general-purpose ingredients normally used in hair nourishment, such as vitamins such as vitamin B6, vitamin E and its derivatives, biotin, pantothenic acid and its derivatives, and glycyrrhetinic acid. and its derivatives, nicotinic acid esters such as benzyl nicotinate, cyclosporins, carpronium chloride, cephalanthine, ogicendrone, diazoxide, minoxidil, hair growth aids such as ethinyl estradiol, hinokitiol, hexachlorophene, phenol,
Antibacterial agents such as benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichlorocarbanilide and bithionol, cooling agents such as menthol, drugs such as salicylic acid, zinc and its derivatives, lactic acid and its alkyl esters, and organics such as citric acid. Acids, amino acids such as arginine, oils such as olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids, higher alcohols, polyhydric alcohols such as glycerin and propylene glycol, fragrances, antioxidants, ultraviolet absorbers, pigments, Alcohols such as ethanol, benzyl alcohol, and isopropyl alcohol, water, humectants, thickeners, and the like can be appropriately blended within the range that does not impair the effects of the present invention.
本発明の養毛料は、液状、乳液、軟膏、クリーム、ゲル
、エアゾールなど外皮に適用できる剤型のものであれば
いずれで乙よ<、トニック、コンテ゛イショナー、スカ
ルプトリートメント、シャンプー、リンスなどの形態で
用いられる。The hair nourishment of the present invention may be in any form as long as it can be applied to the outer skin, such as liquid, emulsion, ointment, cream, gel, aerosol, etc., tonic, conditioner, scalp treatment, shampoo, conditioner, etc. used in form.
[実施例]
次に、実施例により本発明について詳細に説明する。本
発明はこれらにより限定されるものではない。配合量は
重量%である。[Example] Next, the present invention will be explained in detail with reference to Examples. The present invention is not limited to these. The blending amount is in weight%.
5αレダクターゼ阻害効果測定法
高安らの方法(S 、 Takayasu、 K 、
Adachi、 J 。5α reductase inhibition effect measurement method Takayasu's method (S, Takayasu, K,
Adachi, J.
CIin、 E ndocrinol、 Metab、
、 3j(、1098−1101(1972))に従
い、大毛根を用い、テストステロンが5α−DHTに還
元される量を測定し、各生薬によるレダクタアゼ阻害作
用を検討し、結果を表1にホした。CIin, Endocrinol, Metab,
, 3j (, 1098-1101 (1972)), the amount of testosterone reduced to 5α-DHT was measured using large hair roots, and the reductase inhibitory effect of each crude drug was examined. The results are shown in Table 1.
(以下余白)
表−1人毛板テストステロンー5α−レダクターゼ阻害
率(%)前記衣1において、大毛根皮脂線における5α
レダクターゼ阻害に対しヌルデ、ネムノキ、サンザシ、
ショウマ、センボウ、サソウ、タクシャ、テンマ、トウ
ジン、ドケイヒ、ナンショクシャシャンボ、リュウガン
からなる群から選ばれる生薬抽出物の一種又は二種以上
にはレダクターゼ阻害作用が明らかに認められた。(Leaving space below) Table 1: Human hair plate testosterone-5α-reductase inhibition rate (%)
for reductase inhibition;
A reductase inhibitory effect was clearly observed in one or more crude drug extracts selected from the group consisting of Japanese cypress, Japanese sardine, Japanese sardine, Japanese sardine, Japanese red bean, Japanese red bean, Dokeihi, Nanshokushashanbo, and Longan.
育毛効果の測定法(マウスでの腎石効果測定)雄のC3
Hマウス(生後60日)を用い、小川らの方法[(No
rmal and Abnormal Epiderm
al Dif−ferentiation ) M、5
eiji and 1.A、Bernstein Hm
m集束用出版会1従い実験を行なった。すなわち、マウ
スの背部毛を約2X4cmの大きさに剃り、翌日より1
日1回ずつ連日サンプル塗布を行ない、毛再生が始まっ
た部分の面積比の変化を求め、毛再生の早さの比較を行
なった。サンプルは各生薬抽出液の乾燥物を75%エタ
ノールに攪拌溶解し、これに界面活性剤を添加、溶解し
サンプルとした。試験には対照として75%エタノール
を用いた。各試料ともマウス10匹ずつを用い、その変
化率の平均値を求めた。20日後毛再生面積の結果を百
分率にて表−2に示した。Method for measuring hair growth effect (measuring kidney stone effect in mice) Male C3
Using H mice (60 days old), Ogawa et al.'s method [(No.
rmal and abnormal epiderm
al Dif-ferentiation) M, 5
eiji and 1. A.Bernstein Hm.
Experiments were conducted in accordance with M Focusing Publishing Association 1. That is, the hair on the back of the mouse was shaved to a size of approximately 2 x 4 cm, and from the next day
Samples were applied once a day, and changes in the area ratio of areas where hair regeneration had started were determined to compare the speed of hair regeneration. Samples were obtained by stirring and dissolving the dried extracts of each herbal medicine in 75% ethanol, and adding and dissolving a surfactant thereto. 75% ethanol was used as a control in the test. Ten mice were used for each sample, and the average value of the rate of change was determined. The results of hair regeneration area after 20 days are shown in percentage in Table 2.
比較例 1
(1)75%エタノール
比較例 2
(1)センブリの
50%エタノール抽出物(乾燥物)
(2)75%エタノール
0.2
残余
比較例 3
(1)トウキの
70%エタノール抽出物(乾燥物)
(2)75%エタノール
0.2
残余
比較例 4
(1)クラン50%エタノール抽出物(乾燥物)0.2
(2)75%エタノール 残余比
較例 5
(1)チクセツニンジンの
50%エタノール抽出物(乾燥物)
(2)75%エタノール
0.2
残余
実施例 1
(1)ヌルデ50%エタノール
抽出物(乾燥物)
(2)75%エタノール
0゜2
残余
実施例 2
(1)タクシャの
70%エタノール抽出物(乾燥物)
(2)75%エタノール
0.2
残余
実施例 3
(1)トウジンの
50%エタノール抽出物(乾燥物)
(2)75%エタノール
0.2
残余
実施例 4
(1)ジメチルラウリルアミンオキシド(2)トウジン
50%エタノール抽出物(乾燥物)
(3)75%エタノール
実施例 5
(1)ジメチルステアリルアミンオキシド(2)ヌルデ
のメタノール抽出物(乾燥物)(3)75%エタノール
実施例 6
(1)ジメチルラウリルアミンオキシド(2)サソウの
50%エタノール抽出物(乾燥物)
(3)75%エタノール
実施例 7
(1)ジメチルステアリルアミンオキシド(2)ドケイ
ヒの1,3−ブチレン
0.1
グリコール抽出物(乾燥物)
(3)75%エタノール
0.1
残余
0.1
残余
0.1
0.1
残余
実施例 8
(1)ドデシルベンゼンスルホネート
(2)ラウリルジメチルアミンオキシド(3)サンザシ
の
70%エタノール抽出物(乾燥物)
(4)75%エタノール
0.05
0.05
0.1
残余
0.1
0.1
残余
実施例 9
(1)ラウリル硫酸ナトリウム
(2)ジメチルラウリルアミンオキシド(3)テンマの
エタノール抽出物(乾燥物)(4)75%エタノール
0.04
0.06
0.1
残余
0.1
実施例 10
(1)ジメチルステアリルアミンオキシド(2)ラウリ
ル硫酸ナトリウム
(3)シコウマの熱水抽出物(乾燥物)0.075
0.025
0.1
(4)75%エタノール
実施例 11
(1)ジメチルステアリルアミンオキシド(2)モノナ
トリウムラウリル
フォスフェート
(3)リュウガの
70%エタノール抽出物(乾燥物)
(4)75%エタノール
実施例 12
(1)ジメチルステアリルアミンオキシド(2)ラウリ
ルメチルタウリンナトリウム(3)サンザシの
メタノール抽出物(乾燥物)
(4)ナンショクシャシャンボ
の熱水抽出物(乾燥物)
(5)75%エタノール
残余
0.15
0.05
0.05
残余
(1)ラウリルアミノ酢酸へタイン 0.03
(2)ラウロイルジェタノールアミド 0.02(
3)テンマの
70%エタノール抽出物(乾燥物) 0.05(4
)ネムノキのメタノール抽出物(乾燥物’> 0.05
(5)トウジンの
プロパツール抽出物(乾燥物) 0.05(6)7
5%エタノール 残余0.03
0.02
実施例 14
(1)ジメチルラウリルアミンオキシド(2)モノナト
リウムラウリル
フォスフェート
0.04
0.01
0.1
0.05
残余
(3)テンマの
70%エタノール抽出物(乾燥物)
(4)ヌルデのメタノール抽出物(乾燥物)(5)ネム
ノキの
プロパツール抽出物(乾燥物)
(6)75%エタノール
0.05
0.05
0.05
残余
実施例 13
実施例 15
(1)ジメチルラウリルアミンオキシド 0.03(
2)ラウリルメチルタウリンナトリウム 0.02(3
)サンザシの
70%エタノール抽出物(乾燥物) 0.05(4
)タクシャの
メタノール抽出物(乾燥物)O,0S
(5)テンマのプロパツール抽出物(乾燥物) 0.0
5(6)75%エタノール 残j
ミ実施例 16
(1)ラウリルアミノ酢酸ベタイン 0.03(
2)ラウロイルジェタノールアミド 0.02(3
)サンザシの
70%エタノール抽出物(乾燥物) 0.05(4
)ショウマのメタノール抽出物(乾燥物) 0.05(
5)リュウガンの
プロパツール抽出物(乾燥物) 0.05(6)7
5%エタノール 残余実施例 1
7
(1)ジメチルオレイルアミンオキシド(2)ラウロイ
ルジェタノールアミド
(3)サンザシの
70%エタノール抽出物(乾燥物)
(4)トウジンのメタノール抽出物(乾燥物)(5)テ
ンマのプロパツール抽出物(乾燥物)(6)75%エタ
ノール
0.03
0.02
0.05
0.05
0.05
残余
実施例 18
(1)ジメチルラウリルアミンオキシド 0.05(
2)ラウリル硫酸ナトリウム 0.01(3
)ドケイヒの
70%エタノール抽出物(乾燥物) 0.04(4
)タクシャのメタノール抽出物(乾燥物) 0.05(
5)トウジンの
プロパツール抽出物(乾燥物) 0.05(6)
75%エタノール 残余実施例1
9 ヘアートニック
以下に示す組成のトニックを調製して実使用にてフケ、
発毛、脱毛等の症状に対する効果を検討した。Comparative example 1 (1) 75% ethanol Comparative example 2 (1) 50% ethanol extract (dry product) of Aspergillus sp. (dry product) (2) 75% ethanol 0.2 Residue Comparative Example 4 (1) Crane 50% ethanol extract (dry product) 0.2
(2) 75% ethanol Residue Comparative Example 5 (1) 50% ethanol extract of Panax ginseng (dried) (2) 75% ethanol 0.2 Residue Example 1 (1) 50% ethanol extract of Nuruda (dried) (2) 75% ethanol 0゜2 Residue Example 2 (1) 70% ethanol extract of Taksha (dried product) (2) 75% ethanol 0.2 Residue Example 3 (1) 50% ethanol of Red Bean Extract (dry product) (2) 75% ethanol 0.2 Remaining Example 4 (1) Dimethyllaurylamine oxide (2) Red bean ginseng 50% ethanol extract (dry product) (3) 75% ethanol Example 5 (1 ) Dimethylstearylamine oxide (2) Methanol extract of Nurdae (dried material) (3) 75% ethanol Example 6 (1) Dimethyllaurylamine oxide (2) 50% ethanolic extract of Soursopsis (dry material) (3) 75% Ethanol Example 7 (1) Dimethylstearylamine oxide (2) Dokeihi's 1,3-butylene 0.1 Glycol extract (dry product) (3) 75% ethanol 0.1 Remaining 0.1 Remaining 0.1 0.1 Residue Example 8 (1) Dodecylbenzenesulfonate (2) Lauryldimethylamine oxide (3) 70% ethanol extract of hawthorn (dry product) (4) 75% ethanol 0.05 0.05 0.1 Residue 0.1 0.1 Remaining Example 9 (1) Sodium lauryl sulfate (2) Dimethyl lauryl amine oxide (3) Ethanol extract of betel chinensis (dry product) (4) 75% ethanol 0.04 0.06 0.1 Remaining 0.1 Example 10 (1) Dimethylstearylamine oxide (2) Sodium lauryl sulfate (3) Hot water extract of Psyllium japonica (dry product) 0.075 0.025 0.1 (4) 75% ethanol Example 11 (1) Dimethylstearylamine oxide (2) Monosodium lauryl phosphate (3) 70% ethanol extract of Ryuga (dried product) (4) 75% ethanol Example 12 (1) Dimethylstearylamine oxide (2) Lauryl Sodium methyltaurine (3) Methanol extract of hawthorn (dry product) (4) Hot water extract of A. sapiensis (dry product) (5) 75% ethanol residue 0.15 0.05 0.05 remainder (1) Laurylaminoacetic acid hetine 0.03
(2) Lauroylgetanolamide 0.02 (
3) 70% ethanol extract of Tenma (dry product) 0.05 (4
) Methanol extract of Album tree (dried product'> 0.05
(5) Coriander ginseng propatool extract (dried product) 0.05 (6) 7
5% ethanol Residue 0.03 0.02 Example 14 (1) Dimethyl lauryl amine oxide (2) Monosodium lauryl phosphate 0.04 0.01 0.1 0.05 Residue (3) 70% ethanol extraction of tenma (dry product) (4) Methanol extract of Nurdae (dry product) (5) Propatool extract of Album albacus (dry product) (6) 75% ethanol 0.05 0.05 0.05 Remaining Example 13 Implementation Example 15 (1) Dimethyl laurylamine oxide 0.03 (
2) Sodium lauryl methyl taurate 0.02 (3
) 70% ethanol extract of hawthorn (dry) 0.05 (4
) Taksha methanol extract (dry product) O,0S (5) Tenma propatool extract (dry product) 0.0
5 (6) 75% ethanol remainder
Example 16 (1) Betaine lauryl aminoacetate 0.03 (
2) Lauroylgetanolamide 0.02 (3
) 70% ethanol extract of hawthorn (dry) 0.05 (4
) Methanol extract of ginger (dried) 0.05 (
5) Longan propatool extract (dried) 0.05 (6) 7
5% ethanol Residual Example 1
7 (1) Dimethyloleylamine oxide (2) Lauroylgetanolamide (3) 70% ethanol extract of hawthorn (dry product) (4) Methanol extract of red bean ginseng (dry product) (5) Propateur extract of betel japonica (dry product) Dry product) (6) 75% ethanol 0.03 0.02 0.05 0.05 0.05 Remaining Example 18 (1) Dimethyl laurylamine oxide 0.05 (
2) Sodium lauryl sulfate 0.01 (3
) 70% ethanol extract of Dokeihi (dry product) 0.04 (4
) Taksha methanol extract (dried) 0.05 (
5) Coriander ginseng propatool extract (dried) 0.05 (6)
75% ethanol Remaining Example 1
9 Hair Tonic A tonic with the composition shown below was prepared and used to treat dandruff,
The effects on symptoms such as hair growth and hair loss were investigated.
フケ、発毛、脱毛等の症状を呈する20名の男性(年齢
24〜60才)に1日1〜2回、1〜5 mQ−ずつ4
力月にわたって塗布し、表−3の結果を得た。1 to 5 mQ-4 doses 1 to 2 times a day to 20 men (24 to 60 years old) exhibiting symptoms such as dandruff, hair growth, and hair loss.
The coating was applied for several months, and the results shown in Table 3 were obtained.
フケ、発毛及び脱毛等の症状に優れていた。It was excellent in treating symptoms such as dandruff, hair growth, and hair loss.
表−2から明らかなように各実施例において毛の再生に
対する効果が認められた。As is clear from Table 2, the effect on hair regeneration was observed in each Example.
(1)トウジン70%エタノール
抽出物(乾燥物)
(2)サンザシ90%エタノール
抽出物(乾燥物)
(3)タクシャのメタノール
抽出物(乾燥物)
(4)ジメチルラウリルアミンオキシド(5)ラウリル
硫酸ナトリウム
(6)プロピレングリコール
(7)ヒアルロン酸ナトリウム
(8)75%エタノール
0.05
1.0
0.5
0.3
0.05
5.0
0.01
残余
前記の表−3においては下記基準により効果判定を行っ
た。(1) 70% ethanol extract of horsetail (dry product) (2) 90% ethanol extract of hawthorn (dry product) (3) Methanol extract of Taksha (dry product) (4) Dimethyl laurylamine oxide (5) Lauryl sulfate Sodium (6) Propylene glycol (7) Sodium hyaluronate (8) 75% ethanol 0.05 1.0 0.5 0.3 0.05 5.0 0.01 Residual Table 3 above is based on the following criteria. The effectiveness was evaluated.
1、フケ防止効果テスト
「無効」とは治療にも拘らず何らの改善もみられないも
の。1. Dandruff prevention effect test ``Ineffective'' means that no improvement is seen despite treatment.
「有効」とはフケの発生が減少したもの。"Effective" means that the occurrence of dandruff has been reduced.
「著効」とはフケの発生が止まったもの。"Remarkable effect" means that dandruff has stopped occurring.
2、発毛効果テスト
「無効」とは治療にも拘らず何らの改善もみられないも
の。2. Hair growth effect test ``Ineffective'' means that no improvement is seen despite treatment.
「有効」とは脱毛部の2/3以上に毛の新生が認められ
るもの。"Effective" means that new hair growth is observed in 2/3 or more of the hair loss area.
「著効」とは脱毛部に毛が生えそろったもの。``Remarkable effect'' means that hair has grown in the hair removal area.
3、脱毛効果テスト
「無効」とは治療にも拘らず何らの改善もみられないも
の。3. Hair removal effect test ``Ineffective'' means that no improvement is seen despite treatment.
「有効」とは脱毛の進行が減少したもの。"Effective" means that the progression of hair loss has been reduced.
「著効」とは脱毛が止まったもの。“Remarkable response” means that hair loss has stopped.
実施例20 ヘアートニック
(1)リュウガンの
メタノール抽出物(乾燥物)
(2)タクシャの
80%エタノール抽出物(乾燥物)
0.05
0.05
(3)ドケイヒの1,3−ブチレン
グリコール抽出物(乾燥物)
(4)サソウの
90%エタノール抽出物(乾燥物)
(5)ネムノキの熱水抽出物(乾燥物)(6)サンザシ
の
70%エタノール抽出物(乾燥物)
(7)ポリオキシエチレン(8モル)
オレイルアルコールエーテル
(8)1.3−ブチレングリコール
(9)60%エタノール
実施例21 シャンプー
(1)ココイルメチルタウリンナトリウム(2)ラウリ
ルジメチルアミノ酢酸ベタイン(3)ラウリン酸ジェタ
ノールアミド
(4)エチレングリコール脂肪酸エステル(5)プロピ
レングリコール
(6)トウジンの
70%エタノール抽出物(乾燥物)
0.05
0.05
0.05
0.05
0.05
0.05
残余
6.0
8.0
4.0
1.5
2.0
1.0
(7)センボウの
50%エタノール抽出物(乾燥物)
(8)ショウマの
メタノール抽出物(乾燥物)
(9)ネムノキのプロピレン
グリコール抽出物(乾燥物)
(10)エデト酸2ナトリウム
(11)香料
(12)精製水
1.0
1.0
0.2
0.1
適量
残部
実施例22 リンス
(1)ステアリルトリメチル
アンモニウムクロリド 1.5(2)セチル
アルコール 2.0(3)シリコン
油 3.0(4)ポリオキシ
エチレン(10モル)オレイルアルコールエーテル
1.0(5)グリセリン
5.0(6)トウジンのメタノール抽出物(乾燥物)
0.5(7)リュウガンの
メタノール抽出物(乾燥物)
(8)タクシャの熱水抽出物(乾燥物)(9)サンザシ
の
70%エタノール抽出物(乾燥物)
(10)精製水
(11)防腐剤
(12)紫外線吸収剤
実施例23 ヘアクリーム
(1)ミツロウ
(2)ワセリン
(3)流動パラフィン
(4)ポリオキシエチレン(5モル)
ステアリン酸エステル
(5)ポリオキシエチレン(6モル)
オレイルアルコールエーテル
(6)サソウの
90%プロパツール抽出物(乾燥物)
(7)センボウの
50%メタノール抽出物(乾燥物)
0.5
1.0
1.0
84、O
適量
適量
(8)ショウマの
70%エタノール抽出物(乾燥物)
(9)精製水
(10)香料
(11)防腐剤
0.4
35.1
適量
適量
実施例20〜23は、いずれも養毛効果に優れていた。Example 20 Hair tonic (1) Methanol extract of Longan (dried product) (2) 80% ethanol extract of Taksha (dry product) 0.05 0.05 (3) 1,3-butylene glycol extract of Dokeihi (Dry product) (4) 90% ethanol extract of Soursopsis (dry product) (5) Hot water extract of Hawthorn (dry product) (6) 70% ethanol extract of Hawthorn (dry product) (7) Polyoxy Ethylene (8 moles) Oleyl alcohol ether (8) 1,3-butylene glycol (9) 60% ethanol Example 21 Shampoo (1) Sodium cocoyl methyl taurate (2) Betaine lauryldimethylaminoacetate (3) Lauric acid jetanolamide (4) Ethylene glycol fatty acid ester (5) Propylene glycol (6) 70% ethanol extract of red pepper (dry product) 0.05 0.05 0.05 0.05 0.05 0.05 Remaining 6.0 8. 0 4.0 1.5 2.0 1.0 (7) 50% ethanol extract of Japanese cabbage (dry product) (8) Methanol extract of Japanese ginger (dry product) (9) Propylene glycol extract of Album tree (dry product) (10) Disodium edetate (11) Fragrance (12) Purified water 1.0 1.0 0.2 0.1 Appropriate amount Remaining Example 22 Rinse (1) Stearyltrimethylammonium chloride 1.5 (2) Cetyl Alcohol 2.0 (3) Silicone oil 3.0 (4) Polyoxyethylene (10 mol) Oleyl alcohol ether
1.0 (5) Glycerin
5.0 (6) Methanol extract of red pepper (dry product)
0.5 (7) Methanol extract of longan (dry product) (8) Hot water extract of Taksha (dry product) (9) 70% ethanol extract of hawthorn (dry product) (10) Purified water (11) Preservative (12) Ultraviolet absorber Example 23 Hair cream (1) Beeswax (2) Vaseline (3) Liquid paraffin (4) Polyoxyethylene (5 moles) Stearate (5) Polyoxyethylene (6 moles) Oleyl Alcohol ether (6) 90% propatool extract of Japanese cabbage (dry product) (7) 50% methanol extract of Japanese cabbage (dry product) 0.5 1.0 1.0 84, O Appropriate amount Appropriate amount (8) Ginger 70% ethanol extract (dry product) (9) Purified water (10) Fragrance (11) Preservative 0.4 35.1 Appropriate amount Appropriate amount Examples 20 to 23 were all excellent in hair growth effect.
3.0
15.0
42.0
3.0
1.0
[発明の効果1
本発明の養毛料は、特定の生薬抽出物または、特定の生
薬抽出物と特定の界面活性剤とを含有することにより、
従来の養毛料よりも著しく優れた各種の性質(例えば、
発毛、育毛、脱毛防止効果等)を示す。3.0 15.0 42.0 3.0 1.0 [Effect of the invention 1 The hair nourishment of the present invention contains a specific crude drug extract or a specific crude drug extract and a specific surfactant. According to
Various properties that are significantly superior to conventional hair nourishing agents (e.g.
hair growth, hair growth, hair loss prevention effects, etc.).
0.3 特許出願人 株式会社 資生堂 0.20.3 Patent applicant: Shiseido Co., Ltd. 0.2
Claims (4)
ウ、サソウ、タクシャ、テンマ、トウジン、ドケイヒ、
ナンショクシャシャンボ、リュウガンからなる群から選
ばれる生薬抽出物の一種又は二種以上を含有してなる養
毛料。(1) Nurude, nemunoki, hawthorn, shoma, senbo, sansou, takusha, tenma, tojin, dokeihi,
A hair nourishing agent containing one or more crude drug extracts selected from the group consisting of Nanshokushashanbo and Longan.
ウ、サソウ、タクシャ、テンマ、トウジン、ドケイヒ、
ナンショクシャシャンボ、リュウガンからなる群から選
ばれる生薬の抽出物の一種又は二種以上と、アニオン性
界面活性剤の一種又は二種以上と、アニオン界面活性剤
以外で分子内に窒素原子を有する界面活性剤の一種又は
二種以上とを含有することを特徴とする養毛料。(2) Nurude, nemunoki, hawthorn, shoma, senbo, sansou, takusha, tenma, tojin, dokeihi,
One or more extracts of herbal medicines selected from the group consisting of Nanshokushashanbo and Longan, one or two or more anionic surfactants, and an interface other than the anionic surfactant that has a nitrogen atom in its molecule. A hair nourishing agent containing one or more active agents.
ウ、サソウ、タクシャ、テンマ、トウジン、ドケイヒ、
ナンショクシャシャンボ、リュウガンからなる群から選
ばれる生薬の抽出物の一種又は二種以上と、両性界面活
性剤と半極性界面活性剤の一種または二種以上と、分子
内に窒素原子を有する非イオン界面活性剤の一種または
二種以上とを含有することを特徴とする養毛料。(3) Nurude, nemunoki, hawthorn, shoma, senbo, sansou, takusha, tenma, toujin, dokeihi,
One or more extracts of herbal medicines selected from the group consisting of Nanshokushashanbo and Longan, one or two or more amphoteric surfactants and semipolar surfactants, and nonionic substances having a nitrogen atom in the molecule. A hair nourishing agent containing one or more surfactants.
ウ、サソウ、タクシャ、テンマ、トウジン、ドケイヒ、
ナンショクシャシャンボ、リュウガンからなる群から選
ばれる生薬の抽出物の一種又は二種以上と、アミンオキ
シドとを含有することを特徴とする養毛料。(4) Nurude, nemunoki, hawthorn, shoma, senbo, sapou, takusha, tenma, toujin, dokeihi,
A hair nourishing agent characterized by containing one or more extracts of herbal medicines selected from the group consisting of A. chinensis and longan, and an amine oxide.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63198886A JP2676154B2 (en) | 1988-08-11 | 1988-08-11 | Hair restoration |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63198886A JP2676154B2 (en) | 1988-08-11 | 1988-08-11 | Hair restoration |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH0248515A true JPH0248515A (en) | 1990-02-19 |
JP2676154B2 JP2676154B2 (en) | 1997-11-12 |
Family
ID=16398567
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP63198886A Expired - Fee Related JP2676154B2 (en) | 1988-08-11 | 1988-08-11 | Hair restoration |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2676154B2 (en) |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02218604A (en) * | 1989-02-21 | 1990-08-31 | Kanebo Ltd | Hair-tonic cosmetic |
FR2676649A1 (en) * | 1991-05-22 | 1992-11-27 | Lvmh Rech | COSMETIC OR PHARMACEUTICAL COMPOSITION, ESPECIALLY DERMATOLOGICAL, FOR PROMOTING PIGMENTATION OF THE SKIN OR HAIR, CONTAINING A CYPERUS EXTRACT AND PROCESS FOR PRODUCING THE SAME. |
JPH10265350A (en) * | 1997-03-26 | 1998-10-06 | Shiseido Co Ltd | Hair tonic |
JPH10265349A (en) * | 1997-03-26 | 1998-10-06 | Shiseido Co Ltd | Hair tonic |
JP2000143488A (en) * | 1998-11-16 | 2000-05-23 | Ichimaru Pharcos Co Ltd | Cosmetic composition containing humectant plant extract |
JP2002212040A (en) * | 2001-01-19 | 2002-07-31 | Kanebo Ltd | Gray hair preventing cosmetic |
WO2008149437A1 (en) * | 2007-06-06 | 2008-12-11 | Shokando Co., Ltd. | Oral hair nourishment for treating multiple alopecia |
WO2009082797A1 (en) * | 2007-12-28 | 2009-07-09 | Instituto Nacional De Pesquisa Da Amazônia - Inpa | Active formulations based on essential oil of plants of the genus protium, guatteria, cyperus and the mixture thereof |
JP2010235548A (en) * | 2009-03-31 | 2010-10-21 | Maruzen Pharmaceut Co Ltd | Antioxidant agent, anti-inflammatory agent, skin whitening ing agent, anti-aging agent, hair growing agent, and antiobesity agent, as well as cosmetic and food and drink |
JP2013010796A (en) * | 2012-10-15 | 2013-01-17 | Kao Corp | Control agent for expression of s100a8 |
WO2013046137A2 (en) | 2011-09-27 | 2013-04-04 | Sederma | New cosmetic use of an albizia julibrissin extract and corresponding topical composition |
JP2013112684A (en) * | 2011-11-29 | 2013-06-10 | Amorepacific Corp | Composition for prevention of depilation or promotion of hair growth |
JP2013136551A (en) * | 2011-12-28 | 2013-07-11 | Kao Corp | Keratin fiber modifier |
EP2818158A1 (en) | 2013-06-24 | 2014-12-31 | Caster | Cosmetic compositions including plant extracts for controlling skin ageing |
CN111920717A (en) * | 2020-08-19 | 2020-11-13 | 何礼明 | Natural hair dye and preparation method and use method thereof |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101920877B1 (en) * | 2017-02-09 | 2018-11-21 | 강원대학교산학협력단 | Composition for promoting hair growth and the method thereof |
-
1988
- 1988-08-11 JP JP63198886A patent/JP2676154B2/en not_active Expired - Fee Related
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02218604A (en) * | 1989-02-21 | 1990-08-31 | Kanebo Ltd | Hair-tonic cosmetic |
FR2676649A1 (en) * | 1991-05-22 | 1992-11-27 | Lvmh Rech | COSMETIC OR PHARMACEUTICAL COMPOSITION, ESPECIALLY DERMATOLOGICAL, FOR PROMOTING PIGMENTATION OF THE SKIN OR HAIR, CONTAINING A CYPERUS EXTRACT AND PROCESS FOR PRODUCING THE SAME. |
US5476651A (en) * | 1991-05-22 | 1995-12-19 | Lvmh Recherche | Cosmetic or pharmaceutical composition, especially dermatological composition, intended for promoting the pigmentation of the skin or hair, containing an extract of cyperus, and the process for its manufacture |
JPH10265350A (en) * | 1997-03-26 | 1998-10-06 | Shiseido Co Ltd | Hair tonic |
JPH10265349A (en) * | 1997-03-26 | 1998-10-06 | Shiseido Co Ltd | Hair tonic |
JP2000143488A (en) * | 1998-11-16 | 2000-05-23 | Ichimaru Pharcos Co Ltd | Cosmetic composition containing humectant plant extract |
JP2002212040A (en) * | 2001-01-19 | 2002-07-31 | Kanebo Ltd | Gray hair preventing cosmetic |
WO2008149437A1 (en) * | 2007-06-06 | 2008-12-11 | Shokando Co., Ltd. | Oral hair nourishment for treating multiple alopecia |
EP2222271A4 (en) * | 2007-12-28 | 2012-12-26 | Inst Nac De Pesquisa Da Amazonia Inpa | Active formulations based on essential oil of plants of the genus protium, guatteria, cyperus and the mixture thereof |
WO2009082797A1 (en) * | 2007-12-28 | 2009-07-09 | Instituto Nacional De Pesquisa Da Amazônia - Inpa | Active formulations based on essential oil of plants of the genus protium, guatteria, cyperus and the mixture thereof |
EP2222271A1 (en) * | 2007-12-28 | 2010-09-01 | Instituto Nacional De Pesquisa Da Amazônia - INPA | Active formulations based on essential oil of plants of the genus protium, guatteria, cyperus and the mixture thereof |
JP2010235548A (en) * | 2009-03-31 | 2010-10-21 | Maruzen Pharmaceut Co Ltd | Antioxidant agent, anti-inflammatory agent, skin whitening ing agent, anti-aging agent, hair growing agent, and antiobesity agent, as well as cosmetic and food and drink |
WO2013046137A2 (en) | 2011-09-27 | 2013-04-04 | Sederma | New cosmetic use of an albizia julibrissin extract and corresponding topical composition |
US9737476B2 (en) | 2011-09-27 | 2017-08-22 | Sederma | Cosmetic use of an albizia julibrissin extract and corresponding topical composition |
JP2013112684A (en) * | 2011-11-29 | 2013-06-10 | Amorepacific Corp | Composition for prevention of depilation or promotion of hair growth |
JP2013136551A (en) * | 2011-12-28 | 2013-07-11 | Kao Corp | Keratin fiber modifier |
JP2013010796A (en) * | 2012-10-15 | 2013-01-17 | Kao Corp | Control agent for expression of s100a8 |
EP2818158A1 (en) | 2013-06-24 | 2014-12-31 | Caster | Cosmetic compositions including plant extracts for controlling skin ageing |
CN111920717A (en) * | 2020-08-19 | 2020-11-13 | 何礼明 | Natural hair dye and preparation method and use method thereof |
CN111920717B (en) * | 2020-08-19 | 2021-04-27 | 何礼明 | Natural hair dye and preparation method and use method thereof |
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