JPH0248515A - Hair tonic - Google Patents

Abstract

PURPOSE:To obtain a hair tonic, containing crude one or more extracts of crude drugs or further one or more surfactants and excellent in promoting effects on prevention of depilation, production, growth of hair, etc. CONSTITUTION:The objective substance obtained by containing one or more extracts of crude drugs selected from Rhus javanica L., Albizzia julibrissin Durazz., crataegi fructus, cimicifuga rhizome, curculiginis rhizoma, cyperi rhizoma, alisma rhizome, gastrodiae rhizoma, codonopsitis radix, pseudolari cortex, nandinae fructus and Vaccinium bracteatum Thunb. and Euphoria longana Lam. or further one or more surfactants as essential ingredients, mixing other normally used ingredients used in hair tonic therewith and then preparing a formulation according to a conventional method. The hair tonic is prepared in the dosage form of a liquid, milky lotion, ointment, cream, gel, aerosol, etc., applicable to the exodermises and used in the form of a tonic, conditioner, scalp treatment, shampoo, rinse, etc. The amounts of the ingredients are 0.005-10wt.% extracts of the crude drugs expressed in terms of dried substances and 0.001-10wt.% surfactants.

Description

Detailed Description of the Invention [Industrial Application Field] The present invention contains novel and safe crude drug extracts or crude drug extracts and surfactants to prevent hair loss, hair growth, The present invention relates to a hair nourishing agent that is highly effective in promoting hair growth.

[Prior art] Physiological symptoms such as male-pattern baldness, baldness, and seborrhea have traditionally been based on increased stimulation of androgen hormones caused by excessive accumulation of androgenic hormones in the metabolic system. It is known. Recently, it has been discovered that the main body of male hormone activity in several organs including hair roots and sebaceous glands is 5α.
- Dihydrotestosterone (hereinafter abbreviated as 5α-DHT), which is well known to be produced when testosterone is reduced by testosterone-5α-reductase (hereinafter abbreviated as reductase) in target organs. There is.

Therefore, it is thought that symptoms such as male-pattern baldness, baldness, and oiliness caused by increased stimulation of androgens can be reduced or prevented by inhibiting reductase. Such inhibitors have been discovered and synthesized. However, the newly synthesized inhibitors to date have a steroid structure or a steroid-like structure, and have the drawback of having some degree of undesirable hormone-like action.

[Problems to be Solved by the Invention] As a result of intensive research into naturally-derived drugs that are effective for hair loss prevention, hair growth, hair growth, etc. and have excellent safety, the present inventors have found that one or two specific crude drug extracts have been developed. The present inventors have discovered that this problem can be solved by using one or more of these specific herbal medicine extracts, or one or more of these specific crude drug extracts, and a specific surfactant, and have completed the present invention.

[Means for solving the problem 1 That is, the invention according to claim 1 is directed to
Hawthorn, Shoma, Senpou, Sasou, Takusha, Tenma, Toujin, Dokeihi, Nanshokushashanbo,
This hair nourishing agent contains one or more crude drug extracts selected from the group consisting of longan.

The invention according to claim 2 comprises one or more extracts of the crude drug according to claim 1, one or more anionic surfactants, and a nitrogen atom in the molecule other than the anionic surfactant. It is a hair nourishing family characterized by containing one or more types of surfactants.

The invention according to claim 3 is characterized in that one or more extracts of the crude drug according to claim 1, one or more amphoteric surfactants and semipolar surfactants, and a nitrogen atom in the molecule. It is a hair-nourishing product characterized by containing one or more nonionic surfactants.

The invention according to claim 4 is a trichophyte containing one or more extracts of the crude drug according to claim 1 and an amine oxide.

Hereinafter, the configuration of the present invention will be explained in detail.

As the crude drug extract used in the present invention, the crude drug is used as a solvent,
For example, extracts obtained by extraction with hot water, lower alcohols such as methanol, ethanol, hydrous lower alcohols, polyhydric alcohols such as propylene glycol, 1-3 butylene glycol, or hydrous alcohols such as hydrous polyhydric alcohols, Examples include extracts obtained by concentrating and drying the extracted extract. The blending amount of the herbal medicine extract in the present invention is 0.005 to 10% by weight, preferably 0.01 to 5% by weight as dry matter in the amount of hair nourishing material. If the weight is less than 0.005, the effects of the present invention will not be sufficiently exhibited, which is not preferable.

The anionic surfactant according to claim 1 includes anionic surfactants having one or more types of carboxylic acid group, sulfonic acid group, sulfuric acid ester group, and phosphoric acid ester group in the molecule. Those having a carboxylic acid group include fatty acid soaps, ether carboxylic acids and their salts, carboxylates such as amino acid and fatty acid condensates, and those having a sulfonate include alkylsulfinates, Sulfosuccinic acid, ester sulfonate, alkylaryl and alkylnaphthalene sulfonate, N-
Acyl sulfonates, formalin condensation sulfonates, etc. have sulfate ester groups, such as sulfated oils,
Ester sulfates, alkyl sulfates, ether sulfates, alkyl allyl ether sulfates, amide sulfates, etc., those having a phosphoric acid ester group include alkyl phosphates, amide phosphates, ether phosphates, alkylaryl sulfates, etc. Ether phosphates and the like can be mentioned. One or more types are arbitrarily selected from these.

Examples of surfactants having a nitrogen atom in the molecule other than the anionic surfactant according to claim 1 include amphoteric surfactants having a nitrogen atom in the molecule, semipolar surfactants, nonionic surfactants, Examples include cationic surfactants. As the amphoteric surfactant, N,N-dimethyl-
carboxybetaine such as N-lauryl root carboxymethyl ammonium betaine, H,N-dimethyl-N-oleyl-H-carboxymethyl ammonium betaine,
Imidacillin derivatives such as 2-lauryl-rupoxyethyl-N-hydroxyethylimidazolinium betaine, 2-lauryl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, coconut alkyl-β-aminopropionic acid sodium salt, N-coconut alkyl-
Examples include aminocarboxylic acid salts such as β-iminodipropionic acid di-soda salt, sulfobetaine, aminobetaine, and the like. Examples of the semipolar surfactant include dimethyl lauryl amine oxide, bis-(2-hydroxyethyl) lauryl amine oxide, and the like. Examples of the nonionic surfactant include fatty acid alkanolamide, polyoxyethylene fatty acid amide, alkanolamine ester, polyoxyethylene alkylamine, and the like.

Examples of cationic surfactants include fatty acid amine salts, alkyl quaternary ammonium salts, aromatic quaternary ammonium salts,
Examples include pyridium salts and imidazolium salts. One or more types are arbitrarily selected from these.

The amphoteric surfactant according to claim 2 includes carboxybetaine such as N,H-dimethyl-N-lauryl-H-carboxymethylammonium betaine, N,N-dimethyl-■-oleyl-N-carboxymethylammonium betaine, 2 -Imidacillin derivatives such as lauryl-N-carboxyethyl-N-hydroxyethylimidazolinium betaine, 2-lauryl-H-carboxymethyl-N-hydroxyethylimidazolinium betaine, toyasialkyl-β-aminopropionic acid sodium salt, N- Examples include aminocarboxylic acid salts such as coconut alkyl-β-iminodipropionic acid di-soda salt, sulfobetaine, aminobetaine, and the like.

Examples of the semipolar surfactant according to claim 2 include dimethyl lauryl amine oxide, bis-(2-hydroxyethyl) lauryl amine oxide, and the like.

Examples of the nonionic surfactant according to claim 2 include fatty acid alkanolamide, polyoxyethylene fatty acid amide, alkanolamine ester, polyoxyethylene alkylamine, and the like.

The amine oxide according to claim 3 has the following general formula (
Examples are A) to (C).

R2N→0 (A) (wherein R1, R2, and R3 represent a straight chain or branched saturated or unsaturated hydrocarbon group having 1 to 24 carbon atoms, and at least one of R1, R2, and R3 is Represents a straight or branched saturated or unsaturated hydrocarbon group having 8 or more carbon atoms.) Specific examples of the amine oxide represented by the general formula (A) include dimethyl lauryl amine oxide, dimethyl myristyl amine oxide, Dimethylcetylamine oxide, dimethylstefurylamine oxide, dimethyloleylamine oxide, dimethyloleylamine oxide,
Examples include methyl dilaurylamine oxide.

CH2CR20H R4N→0 (B) CH2
CR20H (In the formula, R4 represents a straight chain or branched saturated or unsaturated hydrocarbon group having 8 to 24 carbon atoms.) R3 R5 (QCH2CR2) n N→0(C) H3 (In the formula, R5 is a carbon (Represents a straight chain or branched saturated or unsaturated hydrocarbon group having 8 to 24 atoms, and n represents an integer of 1 to 5.) In the present invention, one or more of these amine oxides arbitrarily selected and used.

The total blending amount of the anionic surfactant according to claim 1 and a surfactant other than the anionic surfactant having a nitrogen atom in the molecule is preferably 0.001 to 10% by weight based on the total amount of the trichophyte, The content is preferably 0.01 to 5% by weight. Further, the ratio of the anionic surfactant to the surfactant other than the anionic surfactant having a nitrogen atom in the molecule is preferably 20:1 to 1:20 in terms of molecular ratio, and more preferably The ratio is 10:1 to 1:10.

The total blending amount of one or more amphoteric surfactants and semipolar surfactants according to claim 2 and one or more nonionic surfactants having a nitrogen atom in the molecule is:
The content is preferably 0.001 to 10% by weight, more preferably 0.01 to 5% by weight based on the total amount of hair growth. In addition, one or more types of amphoteric surfactants and semipolar surfactants,
The ratio of one or more nonionic surfactants having a nitrogen atom in the molecule is 20=1 to 1:2 in molecular ratio.
The ratio is preferably 0, more preferably 10:1 to 1:10.

The amount of the amine oxide according to claim 3 is preferably 0.0001 to 20% by weight based on the amount of hair nourishing material. Blend amount is 0
．． If it is less than 0001% by weight, sufficient hair nourishing effect cannot be obtained,
If it exceeds 20% by weight, it is undesirable from the standpoint of formulation and skin irritation.

In addition to the above-mentioned essential ingredients, the hair nourishment according to the present invention includes general-purpose ingredients normally used in hair nourishment, such as vitamins such as vitamin B6, vitamin E and its derivatives, biotin, pantothenic acid and its derivatives, and glycyrrhetinic acid. and its derivatives, nicotinic acid esters such as benzyl nicotinate, cyclosporins, carpronium chloride, cephalanthine, ogicendrone, diazoxide, minoxidil, hair growth aids such as ethinyl estradiol, hinokitiol, hexachlorophene, phenol,
Antibacterial agents such as benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichlorocarbanilide and bithionol, cooling agents such as menthol, drugs such as salicylic acid, zinc and its derivatives, lactic acid and its alkyl esters, and organics such as citric acid. Acids, amino acids such as arginine, oils such as olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids, higher alcohols, polyhydric alcohols such as glycerin and propylene glycol, fragrances, antioxidants, ultraviolet absorbers, pigments, Alcohols such as ethanol, benzyl alcohol, and isopropyl alcohol, water, humectants, thickeners, and the like can be appropriately blended within the range that does not impair the effects of the present invention.

The hair nourishment of the present invention may be in any form as long as it can be applied to the outer skin, such as liquid, emulsion, ointment, cream, gel, aerosol, etc., tonic, conditioner, scalp treatment, shampoo, conditioner, etc. used in form.

[Example] Next, the present invention will be explained in detail with reference to Examples. The present invention is not limited to these. The blending amount is in weight%.

5α reductase inhibition effect measurement method Takayasu's method (S, Takayasu, K,
Adachi, J.

CIin, Endocrinol, Metab,
, 3j (, 1098-1101 (1972)), the amount of testosterone reduced to 5α-DHT was measured using large hair roots, and the reductase inhibitory effect of each crude drug was examined. The results are shown in Table 1.

(Leaving space below) Table 1: Human hair plate testosterone-5α-reductase inhibition rate (%)
for reductase inhibition;
A reductase inhibitory effect was clearly observed in one or more crude drug extracts selected from the group consisting of Japanese cypress, Japanese sardine, Japanese sardine, Japanese sardine, Japanese red bean, Japanese red bean, Dokeihi, Nanshokushashanbo, and Longan.

Method for measuring hair growth effect (measuring kidney stone effect in mice) Male C3
Using H mice (60 days old), Ogawa et al.'s method [(No.
rmal and abnormal epiderm
al Dif-ferentiation) M, 5
eiji and 1. A.Bernstein Hm.
Experiments were conducted in accordance with M Focusing Publishing Association 1. That is, the hair on the back of the mouse was shaved to a size of approximately 2 x 4 cm, and from the next day
Samples were applied once a day, and changes in the area ratio of areas where hair regeneration had started were determined to compare the speed of hair regeneration. Samples were obtained by stirring and dissolving the dried extracts of each herbal medicine in 75% ethanol, and adding and dissolving a surfactant thereto. 75% ethanol was used as a control in the test. Ten mice were used for each sample, and the average value of the rate of change was determined. The results of hair regeneration area after 20 days are shown in percentage in Table 2.

Comparative example 1 (1) 75% ethanol Comparative example 2 (1) 50% ethanol extract (dry product) of Aspergillus sp. (dry product) (2) 75% ethanol 0.2 Residue Comparative Example 4 (1) Crane 50% ethanol extract (dry product) 0.2
(2) 75% ethanol Residue Comparative Example 5 (1) 50% ethanol extract of Panax ginseng (dried) (2) 75% ethanol 0.2 Residue Example 1 (1) 50% ethanol extract of Nuruda (dried) (2) 75% ethanol 0゜2 Residue Example 2 (1) 70% ethanol extract of Taksha (dried product) (2) 75% ethanol 0.2 Residue Example 3 (1) 50% ethanol of Red Bean Extract (dry product) (2) 75% ethanol 0.2 Remaining Example 4 (1) Dimethyllaurylamine oxide (2) Red bean ginseng 50% ethanol extract (dry product) (3) 75% ethanol Example 5 (1 ) Dimethylstearylamine oxide (2) Methanol extract of Nurdae (dried material) (3) 75% ethanol Example 6 (1) Dimethyllaurylamine oxide (2) 50% ethanolic extract of Soursopsis (dry material) (3) 75% Ethanol Example 7 (1) Dimethylstearylamine oxide (2) Dokeihi's 1,3-butylene 0.1 Glycol extract (dry product) (3) 75% ethanol 0.1 Remaining 0.1 Remaining 0.1 0.1 Residue Example 8 (1) Dodecylbenzenesulfonate (2) Lauryldimethylamine oxide (3) 70% ethanol extract of hawthorn (dry product) (4) 75% ethanol 0.05 0.05 0.1 Residue 0.1 0.1 Remaining Example 9 (1) Sodium lauryl sulfate (2) Dimethyl lauryl amine oxide (3) Ethanol extract of betel chinensis (dry product) (4) 75% ethanol 0.04 0.06 0.1 Remaining 0.1 Example 10 (1) Dimethylstearylamine oxide (2) Sodium lauryl sulfate (3) Hot water extract of Psyllium japonica (dry product) 0.075 0.025 0.1 (4) 75% ethanol Example 11 (1) Dimethylstearylamine oxide (2) Monosodium lauryl phosphate (3) 70% ethanol extract of Ryuga (dried product) (4) 75% ethanol Example 12 (1) Dimethylstearylamine oxide (2) Lauryl Sodium methyltaurine (3) Methanol extract of hawthorn (dry product) (4) Hot water extract of A. sapiensis (dry product) (5) 75% ethanol residue 0.15 0.05 0.05 remainder (1) Laurylaminoacetic acid hetine 0.03
(2) Lauroylgetanolamide 0.02 (
3) 70% ethanol extract of Tenma (dry product) 0.05 (4
) Methanol extract of Album tree (dried product'> 0.05
(5) Coriander ginseng propatool extract (dried product) 0.05 (6) 7
5% ethanol Residue 0.03 0.02 Example 14 (1) Dimethyl lauryl amine oxide (2) Monosodium lauryl phosphate 0.04 0.01 0.1 0.05 Residue (3) 70% ethanol extraction of tenma (dry product) (4) Methanol extract of Nurdae (dry product) (5) Propatool extract of Album albacus (dry product) (6) 75% ethanol 0.05 0.05 0.05 Remaining Example 13 Implementation Example 15 (1) Dimethyl laurylamine oxide 0.03 (
2) Sodium lauryl methyl taurate 0.02 (3
) 70% ethanol extract of hawthorn (dry) 0.05 (4
) Taksha methanol extract (dry product) O,0S (5) Tenma propatool extract (dry product) 0.0
5 (6) 75% ethanol remainder
Example 16 (1) Betaine lauryl aminoacetate 0.03 (
2) Lauroylgetanolamide 0.02 (3
) 70% ethanol extract of hawthorn (dry) 0.05 (4
) Methanol extract of ginger (dried) 0.05 (
5) Longan propatool extract (dried) 0.05 (6) 7
5% ethanol Residual Example 1
7 (1) Dimethyloleylamine oxide (2) Lauroylgetanolamide (3) 70% ethanol extract of hawthorn (dry product) (4) Methanol extract of red bean ginseng (dry product) (5) Propateur extract of betel japonica (dry product) Dry product) (6) 75% ethanol 0.03 0.02 0.05 0.05 0.05 Remaining Example 18 (1) Dimethyl laurylamine oxide 0.05 (
2) Sodium lauryl sulfate 0.01 (3
) 70% ethanol extract of Dokeihi (dry product) 0.04 (4
) Taksha methanol extract (dried) 0.05 (
5) Coriander ginseng propatool extract (dried) 0.05 (6)
75% ethanol Remaining Example 1
9 Hair Tonic A tonic with the composition shown below was prepared and used to treat dandruff,
The effects on symptoms such as hair growth and hair loss were investigated.

1 to 5 mQ-4 doses 1 to 2 times a day to 20 men (24 to 60 years old) exhibiting symptoms such as dandruff, hair growth, and hair loss.
The coating was applied for several months, and the results shown in Table 3 were obtained.

It was excellent in treating symptoms such as dandruff, hair growth, and hair loss.

As is clear from Table 2, the effect on hair regeneration was observed in each Example.

(1) 70% ethanol extract of horsetail (dry product) (2) 90% ethanol extract of hawthorn (dry product) (3) Methanol extract of Taksha (dry product) (4) Dimethyl laurylamine oxide (5) Lauryl sulfate Sodium (6) Propylene glycol (7) Sodium hyaluronate (8) 75% ethanol 0.05 1.0 0.5 0.3 0.05 5.0 0.01 Residual Table 3 above is based on the following criteria. The effectiveness was evaluated.

1. Dandruff prevention effect test ``Ineffective'' means that no improvement is seen despite treatment.

"Effective" means that the occurrence of dandruff has been reduced.

"Remarkable effect" means that dandruff has stopped occurring.

2. Hair growth effect test ``Ineffective'' means that no improvement is seen despite treatment.

"Effective" means that new hair growth is observed in 2/3 or more of the hair loss area.

``Remarkable effect'' means that hair has grown in the hair removal area.

3. Hair removal effect test ``Ineffective'' means that no improvement is seen despite treatment.

"Effective" means that the progression of hair loss has been reduced.

“Remarkable response” means that hair loss has stopped.

Example 20 Hair tonic (1) Methanol extract of Longan (dried product) (2) 80% ethanol extract of Taksha (dry product) 0.05 0.05 (3) 1,3-butylene glycol extract of Dokeihi (Dry product) (4) 90% ethanol extract of Soursopsis (dry product) (5) Hot water extract of Hawthorn (dry product) (6) 70% ethanol extract of Hawthorn (dry product) (7) Polyoxy Ethylene (8 moles) Oleyl alcohol ether (8) 1,3-butylene glycol (9) 60% ethanol Example 21 Shampoo (1) Sodium cocoyl methyl taurate (2) Betaine lauryldimethylaminoacetate (3) Lauric acid jetanolamide (4) Ethylene glycol fatty acid ester (5) Propylene glycol (6) 70% ethanol extract of red pepper (dry product) 0.05 0.05 0.05 0.05 0.05 0.05 Remaining 6.0 8. 0 4.0 1.5 2.0 1.0 (7) 50% ethanol extract of Japanese cabbage (dry product) (8) Methanol extract of Japanese ginger (dry product) (9) Propylene glycol extract of Album tree (dry product) (10) Disodium edetate (11) Fragrance (12) Purified water 1.0 1.0 0.2 0.1 Appropriate amount Remaining Example 22 Rinse (1) Stearyltrimethylammonium chloride 1.5 (2) Cetyl Alcohol 2.0 (3) Silicone oil 3.0 (4) Polyoxyethylene (10 mol) Oleyl alcohol ether
1.0 (5) Glycerin
5.0 (6) Methanol extract of red pepper (dry product)
0.5 (7) Methanol extract of longan (dry product) (8) Hot water extract of Taksha (dry product) (9) 70% ethanol extract of hawthorn (dry product) (10) Purified water (11) Preservative (12) Ultraviolet absorber Example 23 Hair cream (1) Beeswax (2) Vaseline (3) Liquid paraffin (4) Polyoxyethylene (5 moles) Stearate (5) Polyoxyethylene (6 moles) Oleyl Alcohol ether (6) 90% propatool extract of Japanese cabbage (dry product) (7) 50% methanol extract of Japanese cabbage (dry product) 0.5 1.0 1.0 84, O Appropriate amount Appropriate amount (8) Ginger 70% ethanol extract (dry product) (9) Purified water (10) Fragrance (11) Preservative 0.4 35.1 Appropriate amount Appropriate amount Examples 20 to 23 were all excellent in hair growth effect.

3.0 15.0 42.0 3.0 1.0 [Effect of the invention 1 The hair nourishment of the present invention contains a specific crude drug extract or a specific crude drug extract and a specific surfactant. According to
Various properties that are significantly superior to conventional hair nourishing agents (e.g.
hair growth, hair growth, hair loss prevention effects, etc.).

0.3 Patent applicant: Shiseido Co., Ltd. 0.2

Claims (4)

[Claims] (1) Nurude, nemunoki, hawthorn, shoma, senbo, sansou, takusha, tenma, tojin, dokeihi,
A hair nourishing agent containing one or more crude drug extracts selected from the group consisting of Nanshokushashanbo and Longan. (2) Nurude, nemunoki, hawthorn, shoma, senbo, sansou, takusha, tenma, tojin, dokeihi,
One or more extracts of herbal medicines selected from the group consisting of Nanshokushashanbo and Longan, one or two or more anionic surfactants, and an interface other than the anionic surfactant that has a nitrogen atom in its molecule. A hair nourishing agent containing one or more active agents. (3) Nurude, nemunoki, hawthorn, shoma, senbo, sansou, takusha, tenma, toujin, dokeihi,
One or more extracts of herbal medicines selected from the group consisting of Nanshokushashanbo and Longan, one or two or more amphoteric surfactants and semipolar surfactants, and nonionic substances having a nitrogen atom in the molecule. A hair nourishing agent containing one or more surfactants. (4) Nurude, nemunoki, hawthorn, shoma, senbo, sapou, takusha, tenma, toujin, dokeihi,
A hair nourishing agent characterized by containing one or more extracts of herbal medicines selected from the group consisting of A. chinensis and longan, and an amine oxide.