JP2826142B2 - Dandruff inhibitor composition - Google Patents
Dandruff inhibitor compositionInfo
- Publication number
- JP2826142B2 JP2826142B2 JP1316748A JP31674889A JP2826142B2 JP 2826142 B2 JP2826142 B2 JP 2826142B2 JP 1316748 A JP1316748 A JP 1316748A JP 31674889 A JP31674889 A JP 31674889A JP 2826142 B2 JP2826142 B2 JP 2826142B2
- Authority
- JP
- Japan
- Prior art keywords
- dandruff
- present
- inhibitor composition
- arginine
- hair
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
【発明の詳細な説明】 ［産業上の利用分野］ 本発明はフケ抑制剤組成物に関する。さらに詳しく
は、有効性及び安全性に優れたフケ抑制剤組成物に関す
る。Description: TECHNICAL FIELD The present invention relates to a dandruff inhibitor composition. More specifically, the present invention relates to a dandruff inhibitor composition having excellent efficacy and safety.
［従来の技術］ 一般にフケは皮脂腺の分泌物、汗腺の分泌物、表皮層
の剥離物又は脱離物から成り、通常は皮脂腺等の分泌昂
進により発生する。特に細菌や酵母が皮膚に感染する
と、フケの発生が病的に助長されると言われている。こ
のため従来から抗菌剤又は殺菌剤を添加した頭髪化粧料
がフケ防止用頭髪化粧料として使用されてきた。[Related Art] Dandruff generally comprises secretions of sebaceous glands, secretions of sweat glands, and exfoliated or detached products of the epidermal layer, and is usually generated by increased secretion of sebaceous glands and the like. In particular, it is said that when bacteria and yeast infect the skin, dandruff is pathologically promoted. For this reason, hair cosmetics to which an antibacterial agent or a bactericide has been added have conventionally been used as hair cosmetics for preventing dandruff.
［発明が解決しようとする課題］ 従来技術の問題点 しかしながら、殺菌剤や抗菌剤の中には、皮膚刺激性
の点で人体に対する安全性等に問題があるものがあり、
又殺菌剤や抗菌剤を含む頭皮改善剤は連続的な使用によ
り、皮膚常在菌の微妙なバランスをくずしてしまうと言
う、いわゆるエコロジーの観点から、時には望ましくな
い事態を引き起こすことが指摘されている。例えば、従
来からフケ防止用薬剤として最も効果があると認められ
ているジンクピリチオン（ZPT）も抗菌剤の範疇に含ま
れるが、これを多量に用いることはできるだけ避けるこ
とが望ましいと言われている。[Problems to be Solved by the Invention] Problems of the Prior Art However, some bactericides and antibacterial agents have a problem in safety to the human body in terms of skin irritation,
Also, it has been pointed out that scalp improving agents including bactericides and antibacterial agents break the delicate balance of skin-resident bacteria by continuous use, sometimes causing undesirable situations from the viewpoint of so-called ecology. I have. For example, zinc pyrithione (ZPT), which has been conventionally recognized as the most effective drug for preventing dandruff, is also included in the category of antibacterial agents, but it is said that it is desirable to avoid using a large amount of this as much as possible.
発明の目的 本発明は前記従来技術の問題点に鑑みなされたもので
あり、その目的は有効なフケ抑制作用を持ち、しかも頭
皮に対し安全性良好な物質を提供するところにある。SUMMARY OF THE INVENTION The present invention has been made in view of the above-mentioned problems of the prior art, and an object of the present invention is to provide a substance which has an effective dandruff suppressing action and is highly safe for the scalp.
前記目的を達成するために、本発明者らは安全性に優
れた物質の中から、特に頭皮に使用してフケを有効に予
防することができる化合物を得るべく、鋭意研究を重ね
た結果、アルギニン及びその誘導体が増殖性の表皮肥
厚、紅斑を伴う乾燥、落屑性の変化に対して極めて有効
であることを見出した。In order to achieve the above object, the present inventors have conducted intensive studies in order to obtain a compound capable of effectively preventing dandruff, particularly from a substance having excellent safety, using the scalp, It has been found that arginine and its derivatives are extremely effective against proliferative epidermal thickening, desiccation accompanied by erythema, and desquamation.
上記化合物がプロテアーゼ阻害作用を有することは公
知であるが、フケ抑制に対する作用は報告されておら
ず、またフケ抑制剤への応用も知られていない。It is known that the above compounds have a protease inhibitory effect, but no effect on dandruff suppression has been reported, and no application to a dandruff inhibitor has been known.
上記知見に基いて本発明を完成するに至った。 The present invention has been completed based on the above findings.
［課題を解決するための手段］ すなわち本発明はアルギニン及びその誘導体から選ば
れる一種または二種以上を含有することを特徴とするフ
ケ抑制剤組成物を提供するものである。[Means for Solving the Problems] That is, the present invention provides a dandruff inhibitor composition containing one or more selected from arginine and derivatives thereof.
以下、本発明の構成について詳述する。 Hereinafter, the configuration of the present invention will be described in detail.
本発明にはアルギニン及びその誘導体が使用される
が、それは下記一般式で表される。In the present invention, arginine and its derivatives are used, which are represented by the following general formula.
R1＝H,D−Phe−Pro,Glu−Gly,Ile−Glu−Gly,Pro−Phe,
Ala−Phe R2＝OH,CH2Cl 本発明では、これらの中から一種または二種以上を任
意に選択できる。 R 1 = H, D-Phe-Pro, Glu-Gly, Ile-Glu-Gly, Pro-Phe,
Ala-Phe R 2 = OH, CH 2 Cl In the present invention, one or more of these can be arbitrarily selected.
本発明のフケ抑制剤組成物中へのアルギニン及びその
誘導体の配合量は組成物全量中0.001〜10重量％、好ま
しくは0.1〜５重量％である。0.001重量％未満では本発
明の効果が充分得られず、10重量％を越えると、製剤上
あるいはコスト的に好ましくない。The compounding amount of arginine and its derivative in the dandruff inhibitor composition of the present invention is 0.001 to 10% by weight, preferably 0.1 to 5% by weight based on the total amount of the composition. If the amount is less than 0.001% by weight, the effect of the present invention cannot be sufficiently obtained, and if it exceeds 10% by weight, it is not preferable in terms of formulation or cost.
本発明のフケ抑制剤組成物は前記の必須成分に加え
て、必要に応じ、本発明の効果を損なわない範囲内で、
化粧品、医薬部外品、医薬品等に一般に用いられる各種
成分、水性成分、保湿剤、増粘剤、防腐剤、酸化防止
剤、香料、色剤、薬剤、生薬などを配合することができ
る。The dandruff inhibitor composition of the present invention, in addition to the above essential components, if necessary, within a range that does not impair the effects of the present invention,
Various components, aqueous components, humectants, thickeners, preservatives, antioxidants, fragrances, coloring agents, drugs, crude drugs and the like commonly used in cosmetics, quasi-drugs, pharmaceuticals and the like can be blended.
また、本発明のフケ抑制剤組成物は任意の剤型、例え
ば、シャンプー、リンス等の頭髪化粧料、ヘアトニッ
ク、ヘアコンデショナー、スカルプトリートメント等の
養毛料、ヘアリキッド、ヘアースプレイ、ヘアクリーム
等の整髪料、等の剤型をとることができる。Further, the dandruff inhibitor composition of the present invention may have any dosage form, for example, hair cosmetics such as shampoo and rinse, hair tonic, hair conditioner, hair restoration such as scalp treatment, hair liquid, hair spray, hair cream and the like. It can be in the form of a hairdressing agent and the like.
［発明の効果］ 本発明のフケ抑制剤組成物は、安全でフケを有効に防
止することができる。また、本発明のフケ抑制剤組成物
は特にシャンプー、リンス等の界面活性剤に起因する頭
皮刺激により発生するフケの予防及び治療に有効性が高
い。さらに頭皮のかゆみ防止にも高い効果を有する。[Effect of the Invention] The dandruff inhibitor composition of the present invention is safe and can effectively prevent dandruff. In addition, the dandruff inhibitor composition of the present invention is particularly effective in preventing and treating dandruff caused by scalp irritation caused by surfactants such as shampoo and rinse. In addition, it is highly effective in preventing itching of the scalp.
［実施例］ 次に実施例をあげて本発明をさらに詳細に説明する。
本発明はこれらにより限定されるものではない。配合量
は重量％である。[Examples] Next, the present invention will be described in more detail with reference to examples.
The present invention is not limited by these. The compounding amount is% by weight.
実施例に先立ち、本発明で用いた評価法、試験法を説
明する。Prior to the examples, evaluation methods and test methods used in the present invention will be described.
実使用試験 フケ症で悩む、年齢18〜40歳の男子60名、女子40名を
対象に、表−１の実施例１〜３、比較例１のヘアトニッ
クを毎日洗髪後に使用してもらい、２週間後に症状を評
価した。また表−２の実施例４〜６、比較例２のシャン
プーについては毎日シャンプーしてもらい、同様に２週
間後に症状を評価した。その結果を表−４に示す。Actual use test 60 boys aged 18 to 40 years old, suffering from dandruff, targeting 60 girls and 40 women, were asked to use the hair tonics of Examples 1 to 3 and Comparative Example 1 of Table 1 daily after washing their hair. Two weeks later, symptoms were evaluated. The shampoos of Examples 4 to 6 and Comparative Example 2 in Table 2 were shampooed daily, and the symptoms were evaluated two weeks later. Table 4 shows the results.
尚、上記のアルギニン及びその誘導体１〜４は表−３
に示すとおりである。 The above-mentioned arginine and its derivatives 1-4 are shown in Table-3.
As shown in FIG.
（評価） 実使用によるフケの予防、治療の効果を次の４段階で
評価した。 (Evaluation) The effects of prevention and treatment of dandruff by actual use were evaluated in the following four stages.
著効：著しいフケの減少とかゆみの消失 有効：フケの減少とかゆみの軽減 やや有効：フケの減少かかゆみの軽減かのどちらかを認
める 悪化：使用によりフケが増加、かゆみの増悪 表−４から明らかなように本発明のフケ抑制剤組成物
はフケの発生予防、治療およびかゆみの改善に優れた効
果を示した。Significant effect: Remarkable decrease in dandruff and disappearance of itch Effective: Reduction of dandruff and reduction of itch Slightly effective: Either reduction of dandruff or reduction of itch is recognized. As is evident from Table 4, the dandruff inhibitor composition of the present invention exhibited excellent effects in preventing and treating dandruff and improving itching.
実施例７ ヘアトニック 重量％ （１）アルギニン誘導体１ 1.0 （２）ラウリルジメチルアミンオキシド 0.5 （３）ラウリル硫酸ナトリウム 0.05 （４）プロピレングリコール 5.0 （５）ヒアルロン酸ナトリウム 0.01 （６）香料 適量 （７）75％エタノール 残余 実施例８ リンス 重量％ （１）アルギニン誘導体２ 0.3 （２）アルギニン誘導体４ 0.05 （３）ステアリルトリメチル アンモニウムクロライド 2.0 （４）セチルアルコール 2.0 （５）シリコン油 3.0 （６）ポリオキシエチレン （10モル）オレイルアルコールエーテル 1.0 （７）グリセリン 5.0 （８）防腐剤 適量 （９）香料 適量 （10）精製水 残余 実施例９ 頭皮用乳液 重量％ （１）アルギニン誘導体１ 1.0 （２）アルギニン誘導体３ 1.0 （３）アルギニン 1.0 （４）ステアリン酸 1.5 （５）セチルアルコール 0.5 （６）ミツロウ 2.0 （７）ポリオキシエチレン （10モル）モノオレイン酸エステル 1.0 （８）プロピレングリコール 5.0 （９）エタノール 3.0 （10）防腐剤 適量 （11）香料 適量 （12）精製水 残余 実施例10 ヘアトニック 重量％ （１）アルギニン誘導体３ 0.001 （２）ポリオキシエチレン（８モル） オレイルアルコールエーテル 0.05 （３）１・３−ブチレングリコール 0.2 （４）香料 適量 （５）60％エタノール 残余 実施例11 シャンプー 重量％ （１）アルギニン誘導体２ 5.0 （２）ココイルメチルタウリンナトリウム 1.0 （３）ラウリン酸ジエタノールアミド 4.5 （４）エチレングリコール脂肪酸エステル 2.0 （５）プロピレングリコール 3.5 （６）エデト酸２ナトリウム 0.1 （７）ラウリルジメチルアミノ酢酸ベタイン 5.0 （８）香料 適量 （９）精製水 残余Example 7 Hair tonic weight% (1) Arginine derivative 1 1.0 (2) Lauryl dimethylamine oxide 0.5 (3) Sodium lauryl sulfate 0.05 (4) Propylene glycol 5.0 (5) Sodium hyaluronate 0.01 (6) Perfume appropriate amount (7) 75% ethanol residual Example 8 rinse weight% (1) Arginine derivative 2 0.3 (2) Arginine derivative 4 0.05 (3) Stearyl trimethyl ammonium chloride 2.0 (4) Cetyl alcohol 2.0 (5) Silicon oil 3.0 (6) Polyoxyethylene (10 mol) Oleyl alcohol ether 1.0 (7) Glycerin 5.0 (8) Preservative proper amount (9) Fragrance proper amount (10) Purified water residue Example 9 Emulsion for scalp weight% (1) Arginine derivative 1 1.0 (2) Arginine derivative 3 1.0 (3) Arginine 1.0 (4) Stearic acid 1.5 (5) Cet Alcohol 0.5 (6) Beeswax 2.0 (7) Polyoxyethylene (10 mol) monooleate 1.0 (8) Propylene glycol 5.0 (9) Ethanol 3.0 (10) Preservatives proper amount (11) Flavor proper amount (12) Purified water residue Example 10 Hair tonic weight% (1) arginine derivative 3 0.001 (2) polyoxyethylene (8 mol) oleyl alcohol ether 0.05 (3) 1,3-butylene glycol 0.2 (4) perfume appropriate amount (5) 60% ethanol residue Example 11 Shampoo wt% (1) Arginine derivative 2 5.0 (2) Sodium cocoyl methyltaurine 1.0 (3) Lauric acid diethanolamide 4.5 (4) Ethylene glycol fatty acid ester 2.0 (5) Propylene glycol 3.5 (6) Disodium edetate 0.1 (7) Betaine lauryldimethylaminoacetate 5.0 (8) Incense (9) Purified water residue
───────────────────────────────────────────────────── フロントページの続き (58)調査した分野(Int.Cl.6，ＤＢ名) A61K 7/06──────────────────────────────────────────────────続 き Continued on the front page (58) Field surveyed (Int.Cl. 6 , DB name) A61K 7/06
Claims (1)
ly,Pro−PheまたはAla−Phe（Phe:フェニルアラニン、P
ro:プロリン、Glu:グルタミン酸、Gly:グリシン、Ile:
イソロイシン、Ala:アラニン）、R2は、OHまたはCH2C
l、R3は、Ｈまたは を表す。］ で表されるアルギニン及びその誘導体から選ばれる一種
または二種以上を含有することを特徴とするフケ抑制剤
組成物。1. The following general formula (1): Wherein R 1 is H, D-Phe-Pro-, Glu-Gly, Ile-Glu-G
ly, Pro-Phe or Ala-Phe (Phe: phenylalanine, P
ro: proline, Glu: glutamic acid, Gly: glycine, Ile:
Isoleucine, Ala: alanine), R 2 is OH or CH 2 C
l and R 3 are H or Represents ] An anti-dandruff composition comprising one or more selected from arginine and derivatives thereof represented by the following formula:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1316748A JP2826142B2 (en) | 1989-12-06 | 1989-12-06 | Dandruff inhibitor composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1316748A JP2826142B2 (en) | 1989-12-06 | 1989-12-06 | Dandruff inhibitor composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03178922A JPH03178922A (en) | 1991-08-02 |
| JP2826142B2 true JP2826142B2 (en) | 1998-11-18 |
Family
ID=18080475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1316748A Expired - Fee Related JP2826142B2 (en) | 1989-12-06 | 1989-12-06 | Dandruff inhibitor composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2826142B2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19520662A1 (en) * | 1995-06-07 | 1996-12-12 | Beiersdorf Ag | Treatment for dandruff and hair |
| US6432394B2 (en) * | 1999-04-19 | 2002-08-13 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc | Hair conditioning compositions comprising one or more dibasic amino acids |
| CN110934762B (en) * | 2019-10-14 | 2022-08-09 | 澳宝化妆品（惠州）有限公司 | Scalp multi-aspect nursing composition containing arginine derivative and application thereof |
| CN110859766B (en) * | 2019-10-14 | 2022-08-19 | 澳宝化妆品（惠州）有限公司 | Scalp multi-azimuth care composition and application thereof |
-
1989
- 1989-12-06 JP JP1316748A patent/JP2826142B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03178922A (en) | 1991-08-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |