JPH03178921A - Dandruff-suppressing agent composition - Google Patents
Dandruff-suppressing agent compositionInfo
- Publication number
- JPH03178921A JPH03178921A JP1316747A JP31674789A JPH03178921A JP H03178921 A JPH03178921 A JP H03178921A JP 1316747 A JP1316747 A JP 1316747A JP 31674789 A JP31674789 A JP 31674789A JP H03178921 A JPH03178921 A JP H03178921A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- dandruff
- scalp
- lysine
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000001840 Dandruff Diseases 0.000 title claims abstract description 29
- 239000000203 mixture Substances 0.000 title claims abstract description 16
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000004472 Lysine Substances 0.000 claims abstract description 10
- 210000004761 scalp Anatomy 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 7
- 239000003814 drug Substances 0.000 abstract description 6
- -1 perfumery Substances 0.000 abstract description 6
- 235000015961 tonic Nutrition 0.000 abstract description 6
- 230000001256 tonic effect Effects 0.000 abstract description 6
- 239000003795 chemical substances by application Substances 0.000 abstract description 5
- 239000002453 shampoo Substances 0.000 abstract description 5
- 150000001875 compounds Chemical class 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 4
- 239000003676 hair preparation Substances 0.000 abstract description 4
- 229960000716 tonics Drugs 0.000 abstract description 3
- 239000003963 antioxidant agent Substances 0.000 abstract description 2
- 239000003086 colorant Substances 0.000 abstract description 2
- 239000002537 cosmetic Substances 0.000 abstract description 2
- 239000006071 cream Substances 0.000 abstract description 2
- 239000008266 hair spray Substances 0.000 abstract description 2
- 239000003906 humectant Substances 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 abstract description 2
- 239000002562 thickening agent Substances 0.000 abstract description 2
- 238000011282 treatment Methods 0.000 abstract description 2
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 239000000306 component Substances 0.000 abstract 1
- 230000005722 itchiness Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 7
- DYSBKEOCHROEGX-HNNXBMFYSA-N (2s)-6-[(2-methylpropan-2-yl)oxycarbonylamino]-2-(phenylmethoxycarbonylamino)hexanoic acid Chemical compound CC(C)(C)OC(=O)NCCCC[C@@H](C(O)=O)NC(=O)OCC1=CC=CC=C1 DYSBKEOCHROEGX-HNNXBMFYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 208000003251 Pruritus Diseases 0.000 description 6
- 239000003242 anti bacterial agent Substances 0.000 description 6
- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical compound CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 description 6
- 239000003205 fragrance Substances 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 4
- 230000007803 itching Effects 0.000 description 4
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 3
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- UMRUUWFGLGNQLI-QFIPXVFZSA-N (2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid Chemical compound C1=CC=C2C(COC(=O)N[C@@H](CCCCNC(=O)OC(C)(C)C)C(O)=O)C3=CC=CC=C3C2=C1 UMRUUWFGLGNQLI-QFIPXVFZSA-N 0.000 description 2
- GJXKBGKAUIMAKK-HNNXBMFYSA-N (2s)-2-[(4-methylphenyl)sulfonylamino]-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid Chemical compound CC1=CC=C(S(=O)(=O)N[C@@H](CCCCNC(=O)OC(C)(C)C)C(O)=O)C=C1 GJXKBGKAUIMAKK-HNNXBMFYSA-N 0.000 description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 229960000541 cetyl alcohol Drugs 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 229940055577 oleyl alcohol Drugs 0.000 description 2
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- KRULQRVJXQQPQH-SANMLTNESA-N (2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-6-(phenylmethoxycarbonylamino)hexanoic acid Chemical compound C([C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21)CCCNC(=O)OCC1=CC=CC=C1 KRULQRVJXQQPQH-SANMLTNESA-N 0.000 description 1
- 206010000349 Acanthosis Diseases 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- DTPCFIHYWYONMD-UHFFFAOYSA-N decaethylene glycol Polymers OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO DTPCFIHYWYONMD-UHFFFAOYSA-N 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229960002449 glycine Drugs 0.000 description 1
- 235000013905 glycine and its sodium salt Nutrition 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- YFVGRULMIQXYNE-UHFFFAOYSA-M lithium;dodecyl sulfate Chemical compound [Li+].CCCCCCCCCCCCOS([O-])(=O)=O YFVGRULMIQXYNE-UHFFFAOYSA-M 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
【発明の詳細な説明】
「産業上の利用分野］
本発明はフケ抑制剤組成物に関する。さらに詳しくは
リジン及びその誘導体から選ばれる一種または二種以
上を含有することを特徴とし、有効性及び安全性に優れ
たフケ抑制剤組成物に関する。DETAILED DESCRIPTION OF THE INVENTION "Industrial Application Field" The present invention relates to a dandruff suppressant composition.
The present invention relates to a dandruff suppressant composition that is characterized by containing one or more selected from lysine and its derivatives and is excellent in effectiveness and safety.
［従来の技術］
一般にフケは皮脂腺の分泌物、汗腺の分泌物、表皮層の
剥離物又は脱離物から成り、通常は皮脂腺等の分泌昂進
により発生する。特に細菌や酵母が皮膚に感染すると
、フケの発生が病的に助長されると言われている。この
ため従来から抗菌剤又は殺菌剤を添加した頭髪化粧料が
フケ防止用頭髪化粧料として使用されてきた。[Prior Art] Dandruff generally consists of secretions from sebaceous glands, secretions from sweat glands, and peeled or detached substances from the epidermal layer, and is usually caused by increased secretion of sebaceous glands, etc. Especially when bacteria or yeast infect the skin.
It is said that the occurrence of dandruff is pathologically promoted. For this reason, hair cosmetics to which antibacterial agents or bactericidal agents have been added have traditionally been used as hair cosmetics for preventing dandruff.
［発明が解決しようとする課題１
足来致盃旦見凰嘉
しかしながら、殺菌剤や抗菌剤の中には、皮膚刺激性の
点で人体に対する安全性等に問題があるものがあり、又
殺菌剤や抗菌剤を含む頭皮改善剤は連続的な使用により
、皮膚常在菌の微妙なバランスをくずしてしまうと言う
、いわゆるエコロジーの観点から、時には望ましくない
事態を引き起こすことが指摘されている。例えば、従来
からフケ防止用薬剤として最も効果があると認められて
いるジンクビリデオン（ＺＰＴ）も抗菌剤の乾酪に含ま
れるが、これを多量に用いることはできるだけ避けるこ
とが望ましいと言われている。[Problem to be solved by the invention 1] However, some disinfectants and antibacterial agents have safety problems for the human body in terms of skin irritation, and some disinfectants and antibacterial agents have It has been pointed out that continuous use of scalp improvement agents containing antibacterial agents and antibacterial agents can sometimes cause undesirable situations from an ecological perspective, as they disrupt the delicate balance of resident bacteria on the skin. For example, zinc virideon (ZPT), which has traditionally been recognized as the most effective anti-dandruff agent, is also included in the caseation of antibacterial agents, but it is said that it is desirable to avoid using large amounts of this as much as possible.
発明の目的
本発明は前記従来技術の問題点に鑑みなされたものであ
り、その目的は有効なフケ抑制作用を持ち、しかも頭皮
に対し安全性良好な物質を提供するところにある。OBJECTS OF THE INVENTION The present invention has been made in view of the problems of the prior art, and its purpose is to provide a substance that has an effective dandruff suppressing effect and is also safe for the scalp.
前記目的を達成するために、本発明者らは安全性に優れ
た物質の中から、特に頭皮に使用してフケを有効に予防
することができる化合物を得るべく、鋭意研究を重ねた
結果 リジン及びその誘導体が増殖性の表皮肥厚、紅斑
を伴う乾燥、落屑性の変化に対して極めて有効であるこ
と見出した。In order to achieve the above object, the present inventors conducted extensive research to obtain a compound that can be used particularly on the scalp to effectively prevent dandruff from among substances with excellent safety.Lysine It has been found that this compound and its derivatives are extremely effective against proliferative acanthosis, dryness accompanied by erythema, and flaking changes.
−に配化合物がプロテアーゼ阻害作用を有することは公
知であるが、フケ抑制に対する作用は報告されておらず
、フケ抑制剤への応用も知られていない。Although it is known that a compound containing - has a protease inhibitory effect, its effect on dandruff suppression has not been reported, and its application as a dandruff suppressant is also unknown.
−Ｊ−，記知見に基すいて本発明を完成するに至った。-J-, The present invention has been completed based on the above findings.
［課題を解決するための手段］
ずなオ〕ち本発明はリジン及びその誘導体から選ばれる
一種または二種以上を含有することを特徴とするフケ抑
制剤組成物である。[Means for Solving the Problems] The present invention is an anti-dandruff composition characterized by containing one or more selected from lysine and its derivatives.
以下、本発明の構成について詳述する。Hereinafter, the configuration of the present invention will be explained in detail.
本発明にはリジン及びその誘導体が使用されるが、それ
は下記一般式で表される。Lysine and its derivatives are used in the present invention, and are represented by the following general formula.
Ｒ＋−Ｎｌ（−（ＣＨ２）４−ＣＨ ０ ２ Ｈ ３ Ｒ＋”Ｈ。R+-Nl(-(CH2)4-CH 0 2 H 3 R+”H.
ｐｈ６−１１１１ａ、Ａｌａ
ｈｅ
本発明では、これらの中から一種または二種以上を任意
に選択できる。ph6-1111a, Ala he In the present invention, one or more types can be arbitrarily selected from these.
本発明のフケ抑制剤組成物中へのリジン及びその誘導体
の配合量は組成物全量中０．００１〜１０重量％、好ま
しくは０．１〜５重量％である。０．００１重量％未満
では本発明の効果が充分得られず、１０重量％を越える
と、製剤上あるいはコスト的に好ましくない。The amount of lysine and its derivatives incorporated into the dandruff suppressant composition of the present invention is 0.001 to 10% by weight, preferably 0.1 to 5% by weight based on the total amount of the composition. If the amount is less than 0.001% by weight, the effect of the present invention cannot be sufficiently obtained, and if it exceeds 10% by weight, it is unfavorable in terms of formulation or cost.
本発明のフケ抑制剤組成物は前記の必須成分に加えて、
必要に応じ、本発明の効果を損なわない範囲内で、化粧
品、医薬部外品、医薬品等に一般に用いられる各種成分
、水性成分、保湿剤、増粘剤、防腐剤、酸化防止剤、香
料、色剤、薬剤、生薬などを配合することができる。In addition to the above-mentioned essential ingredients, the dandruff suppressant composition of the present invention includes:
If necessary, various ingredients commonly used in cosmetics, quasi-drugs, pharmaceuticals, etc., aqueous ingredients, humectants, thickeners, preservatives, antioxidants, fragrances, Colorants, drugs, herbal medicines, etc. can be added.
また、本発明のフケ抑制剤組成物は任意の剤型、例えば
、シャンプー、リンス等の頭髪化粧料、ヘアトニック、
ヘアコンデショナー、スカルプトリートメント等の養毛
料、ヘアリキッド、ヘアースプレィ、ヘアクリーム等の
整髪料、等の剤型をとることができる。Moreover, the dandruff suppressant composition of the present invention can be used in any dosage form, for example, hair cosmetics such as shampoos and conditioners, hair tonics,
It can take the form of hair nourishing agents such as hair conditioners and scalp treatments, hair styling agents such as hair liquids, hair sprays, and hair creams.
「発明の効果コ
本発明のフケ抑制剤組成物は、安全でフケ゛を有効に防
止することができる。また、本発明のフケ抑制剤組成物
は特にシャンプー、リンス等の界面活性剤に起因する頭
皮刺激により発生ずるフケの予防及び治療に有効性が高
い。さらに頭皮のかゆみ防止にも高い効果を有する。``Effects of the Invention: The dandruff suppressant composition of the present invention is safe and can effectively prevent dandruff. It is highly effective in preventing and treating dandruff caused by scalp irritation.It is also highly effective in preventing itching of the scalp.
［実施例］
次に実施例をあげて本発明をざらに詳細に説明する。本
発明はこれらにより限定されるものではない。配合量は
重量％である。[Example] Next, the present invention will be explained in detail with reference to Examples. The present invention is not limited to these. The blending amount is in weight%.
実施例に先立ち、本発明で用いた評価法、試験法を説明
する。Prior to Examples, evaluation methods and test methods used in the present invention will be explained.
実使用試験
フケ症で悩む、年齢１８〜４０歳の男子６０名、女子４
０名を対象に、表−１の実施例１〜３、比較例１のヘア
トニックを毎日洗髪後に使用してもらい、２週間後に症
状を評価した。また表−２の実施例４〜６、比較例２の
シャンプーについては毎日シャンプーしてもらい、同様
に２週間後に症状を評価した。その結果を表−４に示す
。Practical test: 60 boys and 4 girls aged 18 to 40 suffering from dandruff.
No subjects were asked to use the hair tonics of Examples 1 to 3 and Comparative Example 1 in Table 1 after washing their hair every day, and their symptoms were evaluated two weeks later. In addition, the shampoos of Examples 4 to 6 and Comparative Example 2 in Table 2 were shampooed every day, and the symptoms were similarly evaluated two weeks later. The results are shown in Table 4.
表
尚、
上記のリジン及びその誘導体１〜４は表に示ずとおりで
ある。In addition, the above lysine and its derivatives 1 to 4 are as shown in the table.
１
Ｎｔｔ−（ＣＩ２）４
Ｃｔ（−ＣＯ−Ｒ２
Ｈ
３
０
（評価）
実使用によるフケの予防、治療の効果を次の４段階で評
価した。1 Ntt-(CI2)4 Ct(-CO-R2 H30 (Evaluation) The effectiveness of preventing and treating dandruff through actual use was evaluated in the following four stages.
著効：著しいフケの減少とかゆみの消失有効：フケの減
少とかゆみの軽減
やや有効二フケの減少かかゆみの軽減かのどちらかを認
める
悪化二使用によりフケが増加、かゆみの増悪表−４から
明らかなように本発明のフケ抑制剤組成物はフケの発生
予防、治療およびかゆみの改善に優れた効果を示した。Excellent effect: Significant reduction in dandruff and elimination of itching.Efficacy: Reduction in dandruff and reduction in itch.Slightly effective.2 Reduction in dandruff and reduction in itch.Deterioration.2 Increase in dandruff and exacerbation of itching due to use.Table-4 As is clear from the results, the dandruff suppressant composition of the present invention showed excellent effects in preventing and treating dandruff and improving itching.
実施例７ ヘアトニック
（１）リジン誘導体１
（２）ラウリルジメチルアミンオキシド（３）ラウリル
硫酸すｌ・リウム
（４）プロピレングリコール
（５）ヒアルロン酸ナトリウム
（６）香料
（７） ７５％エタノール
重量％
１．０
０．５
０、Ｏ５
５，０
０，０１
適量
残余
実施例８ リンス
（１）リジン誘導体２
（２）リジン誘導体４
（３）ステアリルトリメチル
アンモニウムクロライド
（４）セチルアルコール
（５）シリコン油
（６）ポリオキシエチレン
（１０モル）オレイル
アルコールエーテル
（７）グリセリン
重量％
０．３
０．０５
２．０
２．０
３．０
１．０
５．０
３
（８）防腐剤
（９）香料
（１０）精製水
実施例９ 頭皮用乳液
（１）リジン誘導体１
（２）リジン誘導体３
（３）リジン
（４）ステアリン酸
（５）セチルアルコール
（６）尖ツロウ
（７）ポリオキシエチレン
（１０モル）モノ
オレイン酸エステル
（８）プロピレングリコール
（９）エタノール
（１０）防腐剤
（１１）香料
（１２）精製水
４
適量
適量
残余
重量％
１．０
１．０
１．０
１．５
０．５
２．０
１．０
５．０
３．０
適量
適量
残余
実施例１０ ヘアトニック
（１）リジン誘導体３゜
重量％
０．００１
（２）ポリオキシエチレン（８モル）
オレイルアルコールエーテル
（３）１ ・３−ブヂレングリコール
（４）香料
（５） ６０％エタノール
０．０５
０．２
適量
残余
実施例１１ シャンプー
（１）リジン誘導体２
（２）ココイルメチル
タウリンナトリウム
（３）ラウリン酸
ジェタノールアミド
（４）エヂレングリコール
脂肪酸エステル
（５）プロピレングリコール
（６）エデト酸２ナトリウム
（７）ラウリルジメチル
重量％
５．０
１．０
４．５
２．０
３．５
０．１
５．０
５
アミノ酢酸ベタイン
（８）
香料
（９）
精製水Example 7 Hair tonic (1) Lysine derivative 1 (2) Lauryl dimethylamine oxide (3) Lithium lauryl sulfate (4) Propylene glycol (5) Sodium hyaluronate (6) Fragrance (7) 75% ethanol by weight 1.0 0.5 0, O5 5,0 0,01 Appropriate amount remaining Example 8 Rinse (1) Lysine derivative 2 (2) Lysine derivative 4 (3) Stearyltrimethylammonium chloride (4) Cetyl alcohol (5) Silicone oil (6) Polyoxyethylene (10 mol) Oleyl alcohol ether (7) Glycerin weight% 0.3 0.05 2.0 2.0 3.0 1.0 5.0 3 (8) Preservative (9) Fragrance (10) Purified water Example 9 Scalp emulsion (1) Lysine derivative 1 (2) Lysine derivative 3 (3) Lysine (4) Stearic acid (5) Cetyl alcohol (6) Point wax (7) Polyoxyethylene (10) mole) Monooleic acid ester (8) Propylene glycol (9) Ethanol (10) Preservative (11) Fragrance (12) Purified water 4 Appropriate amount Appropriate amount Remaining weight % 1.0 1.0 1.0 1.5 0.5 2.0 1.0 5.0 3.0 Appropriate amount Appropriate amount Remaining Example 10 Hair tonic (1) Lysine derivative 3% by weight 0.001 (2) Polyoxyethylene (8 mol) Oleyl alcohol ether (3) 1 ・3-Butylene glycol (4) Fragrance (5) 60% ethanol 0.05 0.2 Appropriate amount Remaining Example 11 Shampoo (1) Lysine derivative 2 (2) Sodium cocoyl methyl taurate (3) Lauric acid jetanolamide ( 4) Ethylene glycol fatty acid ester (5) Propylene glycol (6) Disodium edetate (7) Lauryl dimethyl weight% 5.0 1.0 4.5 2.0 3.5 0.1 5.0 5 Aminoacetic acid Betaine (8) Fragrance (9) Purified water
Claims (1)
種以上を含有することを特徴とするフケ抑制剤組成物。(1) A dandruff suppressant composition containing one or more selected from lysine and its derivatives.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1316747A JPH03178921A (en) | 1989-12-06 | 1989-12-06 | Dandruff-suppressing agent composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1316747A JPH03178921A (en) | 1989-12-06 | 1989-12-06 | Dandruff-suppressing agent composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH03178921A true JPH03178921A (en) | 1991-08-02 |
Family
ID=18080462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1316747A Pending JPH03178921A (en) | 1989-12-06 | 1989-12-06 | Dandruff-suppressing agent composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH03178921A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0747035A3 (en) * | 1995-06-07 | 1998-03-04 | Beiersdorf Aktiengesellschaft | Composition for the treatment of dandruff and the treatment of hair |
| US6432394B2 (en) * | 1999-04-19 | 2002-08-13 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc | Hair conditioning compositions comprising one or more dibasic amino acids |
-
1989
- 1989-12-06 JP JP1316747A patent/JPH03178921A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0747035A3 (en) * | 1995-06-07 | 1998-03-04 | Beiersdorf Aktiengesellschaft | Composition for the treatment of dandruff and the treatment of hair |
| US6432394B2 (en) * | 1999-04-19 | 2002-08-13 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc | Hair conditioning compositions comprising one or more dibasic amino acids |
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