JPH03178920A - Dandruff-suppressing agent composition - Google Patents
Dandruff-suppressing agent compositionInfo
- Publication number
- JPH03178920A JPH03178920A JP1316746A JP31674689A JPH03178920A JP H03178920 A JPH03178920 A JP H03178920A JP 1316746 A JP1316746 A JP 1316746A JP 31674689 A JP31674689 A JP 31674689A JP H03178920 A JPH03178920 A JP H03178920A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- dandruff
- leupeptin
- scalp
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000001840 Dandruff Diseases 0.000 title claims abstract description 30
- 239000000203 mixture Substances 0.000 title claims abstract description 17
- GDBQQVLCIARPGH-ULQDDVLXSA-N leupeptin Chemical compound CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CCCN=C(N)N GDBQQVLCIARPGH-ULQDDVLXSA-N 0.000 claims abstract description 17
- GDBQQVLCIARPGH-UHFFFAOYSA-N Leupeptin Natural products CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(C=O)CCCN=C(N)N GDBQQVLCIARPGH-UHFFFAOYSA-N 0.000 claims abstract description 15
- 108010052968 leupeptin Proteins 0.000 claims abstract description 15
- 230000000694 effects Effects 0.000 abstract description 9
- 210000004761 scalp Anatomy 0.000 abstract description 9
- 239000003814 drug Substances 0.000 abstract description 6
- -1 perfumery Substances 0.000 abstract description 6
- 239000002453 shampoo Substances 0.000 abstract description 6
- 239000003795 chemical substances by application Substances 0.000 abstract description 5
- 235000015961 tonic Nutrition 0.000 abstract description 5
- 230000001256 tonic effect Effects 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 abstract description 4
- 239000003676 hair preparation Substances 0.000 abstract description 4
- 229960000716 tonics Drugs 0.000 abstract description 3
- 239000003963 antioxidant agent Substances 0.000 abstract description 2
- 239000003086 colorant Substances 0.000 abstract description 2
- 239000002537 cosmetic Substances 0.000 abstract description 2
- 239000006071 cream Substances 0.000 abstract description 2
- 239000008266 hair spray Substances 0.000 abstract description 2
- 239000003906 humectant Substances 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 abstract description 2
- 239000004094 surface-active agent Substances 0.000 abstract description 2
- 239000002562 thickening agent Substances 0.000 abstract description 2
- 238000011282 treatment Methods 0.000 abstract description 2
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 239000000306 component Substances 0.000 abstract 1
- 230000005722 itchiness Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 208000003251 Pruritus Diseases 0.000 description 6
- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical compound CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-M Aminoacetate Chemical compound NCC([O-])=O DHMQDGOQFOQNFH-UHFFFAOYSA-M 0.000 description 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Chemical compound CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
- 229960000541 cetyl alcohol Drugs 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 229940055577 oleyl alcohol Drugs 0.000 description 2
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 229940043810 zinc pyrithione Drugs 0.000 description 2
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- BMGMINKVTPDDRZ-UHFFFAOYSA-N 2-acetamido-n-[1-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide;n-[1-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methyl-2-(propanoylamino)pentanamide Chemical compound CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(C=O)CCCN=C(N)N.CCC(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C=O)CCCN=C(N)N BMGMINKVTPDDRZ-UHFFFAOYSA-N 0.000 description 1
- 206010000349 Acanthosis Diseases 0.000 description 1
- 241000186361 Actinobacteria <class> Species 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- 239000004129 EU approved improving agent Substances 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 108010011078 Leupeptins Proteins 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000001496 desquamative effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野］
本発明はフケ抑制剤組成物に関する。さらに詳しくは
ロイペプチンを含有することを特徴とし、有効性及び
安全性に優れたフケ抑制剤組成物に関する。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to anti-dandruff compositions. For more details
The present invention relates to a dandruff suppressant composition containing leupeptin and having excellent efficacy and safety.
［従来の技術］
一般にフケは皮脂腺の分泌物、汗腺の分泌物、表皮層の
剥離物又は脱離物から成り、通常は皮脂腺等の分泌昂進
により発生する。特に細菌や酵母が皮膚に感染すると
、フケの発生が病的に助長されると言われている。この
ため従来から抗菌剤又は殺菌剤を添加した頭髪化粧料が
フケ防止用頭髪化粧料として使用されてきた。[Prior Art] Dandruff generally consists of secretions from sebaceous glands, secretions from sweat glands, and peeled or detached substances from the epidermal layer, and is usually caused by increased secretion of sebaceous glands, etc. Especially when bacteria or yeast infect the skin.
It is said that the occurrence of dandruff is pathologically promoted. For this reason, hair cosmetics to which antibacterial agents or bactericidal agents have been added have traditionally been used as hair cosmetics for preventing dandruff.
［発明が解決しようとする課題］
従来技術の問題点
しかしながら、殺菌剤や抗菌剤の中には、皮膚刺激性の
点で人体に対する安全性等に問題があるものがあり、又
殺菌剤や抗菌剤を含む頭皮改善剤は連続的な使用により
、皮膚常在菌の微妙なバランスをくずしてしまうと言う
、いわゆるエコロジーの観点から、時には望ましくない
事態を引き起こすことが指摘されている。例えば、従来
からフケ防止用薬剤として最も効果があると認められて
いるジンクピリチオン（ＺＰＴ）も抗菌剤の範購に含ま
れるが、これを多量に用いることはできるだけ避けるこ
とが望ましいと言われている。[Problems to be solved by the invention] Problems with the prior art However, some disinfectants and antibacterial agents have safety problems for the human body in terms of skin irritation; It has been pointed out that continuous use of scalp-improving agents, including scalp agents, can disrupt the delicate balance of resident bacteria on the skin, sometimes causing undesirable situations from the so-called ecological point of view. For example, zinc pyrithione (ZPT), which has traditionally been recognized as the most effective anti-dandruff agent, is included in the category of antibacterial agents, but it is said that it is desirable to avoid using large amounts of it as much as possible. .
発明の目的
本発明は前記従来技術の問題点に鑑みなされたものであ
り、その目的は有効なフケ抑制作用を持ち、しかも頭皮
に対し安全性良好な物質を提供するところにある。OBJECTS OF THE INVENTION The present invention has been made in view of the problems of the prior art, and its purpose is to provide a substance that has an effective dandruff suppressing effect and is also safe for the scalp.
前記目的を達成するために、本発明者らは安全量に優れ
た物質の中から、特に頭皮に使用してフケを有効に予防
することができる化合物を得るべく、鋭意研究を重ねた
結果ロイペプチンが増殖性の表皮肥厚、紅斑を伴う乾燥
、落屑性の変化に対して極めて有効であること見出した
。In order to achieve the above object, the present inventors conducted extensive research to obtain a compound that can be used particularly on the scalp to effectively prevent dandruff from among substances with excellent safe amounts, and as a result leupeptin. We found that it is extremely effective against proliferative acanthosis, dryness accompanied by erythema, and desquamative changes.
−４二記化合物がプロテアーゼＩＩＪＩ害作用を有する
ことは／Ｉ□知であるが、フケ抑制に対する作用は報告
されておらず、フケ抑制剤への応用も知られていない。Although it is known that the compound listed under -4 has an adverse effect on protease IIJI, its effect on suppressing dandruff has not been reported, and its application as a dandruff suppressant is also unknown.
上記知見に基すいて本発明を完成するに至った。The present invention was completed based on the above findings.
［課題を解決するための手段１
すなわち本発明はロイペプチンを含有することを特徴と
するフケ抑制剤組成物である。[Means for Solving the Problems 1] That is, the present invention is an anti-dandruff composition characterized by containing leupeptin.
以下、本発明の構成について詳述する。Hereinafter, the configuration of the present invention will be explained in detail.
本発明に使用されるロイペプチンとは下記一般式で表さ
れる物質の総称であり、多くの放線菌により産生きれる
。Leupeptin used in the present invention is a general term for substances represented by the following general formula, and can be produced by many actinomycetes.
Ｒ１−Ｒ２−Ｒ３ ＣＨ ＣＨ−（ＣＨ２）３ ＣＨ ＣＨ ＣＨ２ １１０ ”ＮＩ＋２ Ｒ＋”ＣｔｈＣＯ。R1-R2-R3 CH CH-(CH2)3 CH CH CH2 110 “NI+2 R+”CthCO.
ＣＨ３ＣＨ２ＣＤ Ｒ２，Ｌ−Ｌｅｕ。CH3CH2CD R2, L-Leu.
Ｉｌｅ。Ile.
−Ｖａｌ ３ Ｌ、ｅｕ。-Val 3 L,eu.
Ｌ−１１ｅ。L-11e.
Ｉ。I.
Ｖａｌ
（Ｌ−Ｌｅｕ：ｌ］、イシン
丁ｌｅ：イソロイシン
Ｖａｌ：バリン）
本発明では、これらの中から一種または二種以上を任意
に選択できる。Val (L-Leu:l), isoleucine Val:valine) In the present invention, one or more types can be arbitrarily selected from these.
本発明のフケ抑制剤組成物中へのロイペプチンの配合量
は組成物全量中０．０００１〜１０重量％、好ましくは
０．０１〜５重量％である。０．０００１重量％未満で
は本発明の効果が充分得られず、１０重量％を越えると
、製剤上あるいはコスト的に好ましくない。The amount of leupeptin incorporated into the dandruff suppressant composition of the present invention is 0.0001 to 10% by weight, preferably 0.01 to 5% by weight based on the total amount of the composition. If the amount is less than 0.0001% by weight, the effects of the present invention cannot be sufficiently obtained, and if it exceeds 10% by weight, it is unfavorable in terms of formulation or cost.
本発明のフケ抑制剤組成物は前記の必須成分に加えて、
必要に応じ、本発明の効果を損なわない範囲内で、化粧
品、医薬部外品、医薬品等に一般に用いられる各種成分
、水性成分、保湿剤、増粘剤、防腐剤、酸化防止剤、香
料、色剤、薬剤、生薬などを配合することができる。In addition to the above-mentioned essential ingredients, the dandruff suppressant composition of the present invention includes:
If necessary, various ingredients commonly used in cosmetics, quasi-drugs, pharmaceuticals, etc., aqueous ingredients, humectants, thickeners, preservatives, antioxidants, fragrances, Colorants, drugs, herbal medicines, etc. can be added.
また、本発明のフケ抑制剤組成物は任意の剤型、例えば
、シャンプー、リンス等の頭髪化粧料、ヘアトニック、
ヘアコンテ゛ショナー、スカルプトリートメント等の養
毛料、ヘアリキッド、ヘアースプレィ、ヘアクリーム等
の整髪料、等の剤型をとることができる。Moreover, the dandruff suppressant composition of the present invention can be used in any dosage form, for example, hair cosmetics such as shampoos and conditioners, hair tonics,
It can take the form of hair conditioners, hair nourishing agents such as scalp treatments, hair styling agents such as hair liquids, hair sprays, hair creams, and the like.
［発明の効果］
本発明のフケ抑制剤組成物は、安全でフケを有効に防止
することができる。また、本発明のフケ抑制剤組成物は
特にシャンプー、リンス等の界面活性剤に起因する頭皮
刺激により発生するフケの予防及び治療に有効性が高い
。さらに頭皮のかゆみ防止にも高い効果を有する。[Effects of the Invention] The dandruff suppressant composition of the present invention is safe and can effectively prevent dandruff. Furthermore, the dandruff suppressant composition of the present invention is particularly effective in preventing and treating dandruff caused by scalp irritation caused by surfactants in shampoos, conditioners, and the like. It is also highly effective in preventing itchy scalp.
「実施例］
次に実施例をあげて本発明をさらに詳細に説明する。本
発明はこれらにより限定されるものではない。配合量は
重量％である。"Examples" Next, the present invention will be explained in more detail with reference to Examples.The present invention is not limited by these examples.The blending amounts are expressed in % by weight.
実施例に先立ち、本発明で用いた評価法、試験法を説明
する。Prior to Examples, evaluation methods and test methods used in the present invention will be explained.
実使用試験
フケ症で悩む、年齢１８〜４０歳の男子６０名、女子４
０名を対象に、表−ｌの実施例１〜３、比較例１のヘア
トニックを毎日洗髪後に使用してもらい、２週間後に症
状を評価した。また表−２の実施例４〜６、比較例２の
シャンプーについては毎日シャンプーしてもらい、同様
に２週間後に症状を評価し Ｉこ 。Practical test: 60 boys and 4 girls aged 18 to 40 suffering from dandruff.
No subjects were asked to use the hair tonics of Examples 1 to 3 and Comparative Example 1 in Table 1 after washing their hair every day, and their symptoms were evaluated two weeks later. In addition, the shampoos of Examples 4 to 6 and Comparative Example 2 in Table 2 were shampooed every day, and the symptoms were similarly evaluated two weeks later.
その結果を表 ４に小ず。Display the results 4 small pieces.
表
表−２
尚、
上記のロイペプチン■〜５は表−３に示すとおりである
。Table 2 In addition, the above leupeptins ① to 5 are as shown in Table 3.
１
Ｒ２−Ｒ３−ＮＨ−ＣＩ（−（Ｃｔｈ）３−旧＋−ＣＨ
１
Ｎ）１２
ＨＯ
“旧１２
（評価）
実使用によるフケ゛の予防、治療の効果を次の４段階で
評価した。1 R2-R3-NH-CI(-(Cth)3-old+-CH
1 N) 12 HO “Old 12 (Evaluation) The effectiveness of preventing and treating dandruff through actual use was evaluated on the following four levels.
著効：著しいフケの減少とかゆみの消失有効：フケの減
少とかゆみの軽減
やや有効：フケの減少かかゆみの軽減かのどちらかを認
める
悪化二使用によりフケが増加、かゆみの増悪表−４から
明らかなように本発明のフケ抑制剤組成物はフケの発生
予防、治療およびかゆみの改善に優れた効果を示した。Excellent effect: Significant reduction in dandruff and elimination of itch Effectiveness: Reduction in dandruff and reduction in itch Moderately effective: Reduction in dandruff or reduction in itch (2) Increased dandruff and exacerbation of itch due to use Table 4 As is clear from the results, the dandruff suppressant composition of the present invention showed excellent effects in preventing and treating dandruff and improving itching.
実施例７ ヘアトニック
（１）ロイペプチン］
（２）ラウリルジメチルアミンオキシド（３）ラウリル
硫酸ナトリウム
（４）プロピレングリコール
（５）ヒアルロン酸ナトリウム
（６） 香ネ斗
（７） ７５％エタノール
重量％
１．０
０．５
０．０５
５．０
０．０１
適量
残余
実施例８ リンス
（１）ロイペプチン２
（２） Ｄイペプヂン４
（３）ステアリルトリメチル
アンモニウムクロライド
（４〉セチルアルコール
（５）シリコン油
（６）ポリオキシエチレン
（１０モル）オレイル
アルコールエーテル
（７）グリセリン
重量％
０．３
０．０５
２．０
２．０
３．０
１．０
５．０
３
（８）防腐剤
（９）香料
（１０）精製水
実施例９ 頭皮用乳液
（１）ロイペプチン１
（２）ロイペプチン３
（３）ロイペプチン４
（４）ステアリン酸
（５）セチルアルコール
（６）ミツロウ
（７）ポリオキシエチレン
（１０モル）モノ
オレイン酸エステル
（８）プロピレングリコール
（９）エタノール
（１０）防腐剤
（１１）香料
（１２）精製水
４
適量
適量
残余
重量％
１．０
１．０
１．０
１．５
０．５
２．０
１．０
５．０
３．０
適量
適量
残余
実施例１０ ヘアトニック
（１）ロイペプチン３
（２）ポリオキシエチレン（８モル）
オレイルアルコールエーテル
（３）１・３−ブチレングリコール
（４）香料
（５） ６０％エタノール
重量％
０．００１
０．０５
０．２
適量
残余
実施例１１ シャンプー
（１）ロイペプチン２
（２）ココイルメチル
タウリンナトリウム
（３）ラウリン酸
ジェタノールアミド
（４）エヂレングリコール
脂肪酸エステル
（５）プロピレングリコール
（６）エデト酸２ナトリウム
（７）ラウリルジメチル
重量％
５．０
１．０
４．５
２．０
３．５
０．１
５．０
５
アミノ酢酸ベタイン
（８）
香料
適量
（９）
精製水
残余Example 7 Hair Tonic (1) Leupeptin] (2) Lauryl dimethylamine oxide (3) Sodium lauryl sulfate (4) Propylene glycol (5) Sodium hyaluronate (6) Koneto (7) 75% ethanol weight% 1. 0 0.5 0.05 5.0 0.01 Appropriate amount remaining Example 8 Rinse (1) Leupeptin 2 (2) D-ipeptin 4 (3) Stearyltrimethylammonium chloride (4> Cetyl alcohol (5) Silicone oil (6) Polyoxyethylene (10 mol) Oleyl Alcohol Ether (7) Glycerin Weight % 0.3 0.05 2.0 2.0 3.0 1.0 5.0 3 (8) Preservative (9) Fragrance (10) Purified water Example 9 Scalp emulsion (1) Leupeptin 1 (2) Leupeptin 3 (3) Leupeptin 4 (4) Stearic acid (5) Cetyl alcohol (6) Beeswax (7) Polyoxyethylene (10 mol) Monooleic acid Ester (8) Propylene glycol (9) Ethanol (10) Preservative (11) Flavor (12) Purified water 4 Appropriate amount Appropriate amount Remaining weight% 1.0 1.0 1.0 1.5 0.5 2.0 1. 0 5.0 3.0 Appropriate amount Appropriate amount Remaining Example 10 Hair tonic (1) Leupeptin 3 (2) Polyoxyethylene (8 mol) Oleyl alcohol ether (3) 1,3-butylene glycol (4) Fragrance (5) 60 %ethanol weight% 0.001 0.05 0.2 Appropriate amount remaining Example 11 Shampoo (1) Leupeptin 2 (2) Cocoyl methyl taurate sodium (3) Lauric acid jetanolamide (4) Ethylene glycol fatty acid ester (5) Propylene glycol (6) Disodium edetate (7) Lauryl dimethyl weight% 5.0 1.0 4.5 2.0 3.5 0.1 5.0 5 Betaine aminoacetate (8) Perfume appropriate amount (9) Purification water residual
Claims (1)
制剤組成物。(1) A dandruff suppressant composition containing leupeptin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1316746A JPH03178920A (en) | 1989-12-06 | 1989-12-06 | Dandruff-suppressing agent composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1316746A JPH03178920A (en) | 1989-12-06 | 1989-12-06 | Dandruff-suppressing agent composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH03178920A true JPH03178920A (en) | 1991-08-02 |
Family
ID=18080449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1316746A Pending JPH03178920A (en) | 1989-12-06 | 1989-12-06 | Dandruff-suppressing agent composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH03178920A (en) |
-
1989
- 1989-12-06 JP JP1316746A patent/JPH03178920A/en active Pending
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