JPH0248517A - Hair tonic - Google Patents
Hair tonicInfo
- Publication number
- JPH0248517A JPH0248517A JP63198888A JP19888888A JPH0248517A JP H0248517 A JPH0248517 A JP H0248517A JP 63198888 A JP63198888 A JP 63198888A JP 19888888 A JP19888888 A JP 19888888A JP H0248517 A JPH0248517 A JP H0248517A
- Authority
- JP
- Japan
- Prior art keywords
- chinensis
- surfactants
- hair
- extract
- japonica
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000001256 tonic effect Effects 0.000 title abstract description 6
- 239000000284 extract Substances 0.000 claims abstract description 39
- 239000004094 surface-active agent Substances 0.000 claims abstract description 22
- 239000003814 drug Substances 0.000 claims abstract description 20
- 229940079593 drug Drugs 0.000 claims abstract description 20
- 244000184734 Pyrus japonica Species 0.000 claims abstract description 12
- 240000005378 Magnolia kobus Species 0.000 claims abstract description 6
- 235000014196 Magnolia kobus Nutrition 0.000 claims abstract description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- 239000003945 anionic surfactant Substances 0.000 claims description 11
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 10
- 241000333181 Osmanthus Species 0.000 claims description 8
- 235000019082 Osmanthus Nutrition 0.000 claims description 8
- 235000009108 Urtica dioica Nutrition 0.000 claims description 7
- 150000001412 amines Chemical class 0.000 claims description 7
- 239000002280 amphoteric surfactant Substances 0.000 claims description 7
- 239000002736 nonionic surfactant Substances 0.000 claims description 7
- 244000205574 Acorus calamus Species 0.000 claims description 6
- 235000018185 Betula X alpestris Nutrition 0.000 claims description 6
- 235000018212 Betula X uliginosa Nutrition 0.000 claims description 6
- 235000011996 Calamus deerratus Nutrition 0.000 claims description 6
- 241001412225 Firmiana simplex Species 0.000 claims description 6
- 241001504505 Troglodytes troglodytes Species 0.000 claims description 5
- 241000411851 herbal medicine Species 0.000 claims description 4
- 241000218691 Cupressaceae Species 0.000 claims 9
- 241000219422 Urtica Species 0.000 claims 4
- 239000004615 ingredient Substances 0.000 abstract description 6
- 238000002156 mixing Methods 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 abstract description 4
- 244000080208 Canella winterana Species 0.000 abstract description 2
- 235000008499 Canella winterana Nutrition 0.000 abstract description 2
- 229940017545 cinnamon bark Drugs 0.000 abstract description 2
- 238000009472 formulation Methods 0.000 abstract description 2
- 230000002265 prevention Effects 0.000 abstract description 2
- 230000001737 promoting effect Effects 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract 2
- 235000011570 Artemisia caruifolia var apiacea Nutrition 0.000 abstract 1
- 241000526704 Berberis thunbergii Species 0.000 abstract 1
- 235000001553 Betula platyphylla Nutrition 0.000 abstract 1
- 241001313086 Betula platyphylla Species 0.000 abstract 1
- 240000008397 Ganoderma lucidum Species 0.000 abstract 1
- 235000001637 Ganoderma lucidum Nutrition 0.000 abstract 1
- 240000007049 Juglans regia Species 0.000 abstract 1
- 235000009496 Juglans regia Nutrition 0.000 abstract 1
- 241001362907 Neolepisorus fortunei Species 0.000 abstract 1
- 240000002924 Platycladus orientalis Species 0.000 abstract 1
- 241000218998 Salicaceae Species 0.000 abstract 1
- 240000004584 Tamarindus indica Species 0.000 abstract 1
- 235000004298 Tamarindus indica Nutrition 0.000 abstract 1
- 241001106462 Ulmus Species 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 230000035617 depilation Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 210000000582 semen Anatomy 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 84
- -1 For example Substances 0.000 description 31
- 239000000469 ethanolic extract Substances 0.000 description 26
- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical compound CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 description 18
- 230000000694 effects Effects 0.000 description 18
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 16
- 239000000401 methanolic extract Substances 0.000 description 15
- 230000003779 hair growth Effects 0.000 description 14
- DVEKCXOJTLDBFE-UHFFFAOYSA-N n-dodecyl-n,n-dimethylglycinate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC([O-])=O DVEKCXOJTLDBFE-UHFFFAOYSA-N 0.000 description 13
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 12
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 11
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 11
- 229960003237 betaine Drugs 0.000 description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 10
- 201000004384 Alopecia Diseases 0.000 description 9
- 235000014113 dietary fatty acids Nutrition 0.000 description 9
- 229930195729 fatty acid Natural products 0.000 description 9
- 239000000194 fatty acid Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 8
- 230000003676 hair loss Effects 0.000 description 8
- 208000024963 hair loss Diseases 0.000 description 8
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 7
- 208000001840 Dandruff Diseases 0.000 description 7
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 7
- 150000004665 fatty acids Chemical class 0.000 description 7
- 240000008067 Cucumis sativus Species 0.000 description 5
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 5
- 150000001298 alcohols Chemical class 0.000 description 5
- OZYPPHLDZUUCCI-UHFFFAOYSA-N n-(6-bromopyridin-2-yl)-2,2-dimethylpropanamide Chemical compound CC(C)(C)C(=O)NC1=CC=CC(Br)=N1 OZYPPHLDZUUCCI-UHFFFAOYSA-N 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 230000003660 hair regeneration Effects 0.000 description 4
- 125000001183 hydrocarbyl group Chemical group 0.000 description 4
- 235000021317 phosphate Nutrition 0.000 description 4
- 229920006395 saturated elastomer Polymers 0.000 description 4
- 229930195734 saturated hydrocarbon Natural products 0.000 description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 4
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 4
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 4
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 229940055577 oleyl alcohol Drugs 0.000 description 3
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 150000005846 sugar alcohols Polymers 0.000 description 3
- 125000001273 sulfonato group Chemical class [O-]S(*)(=O)=O 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 229940104261 taurate Drugs 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- PSBDWGZCVUAZQS-UHFFFAOYSA-N (dimethylsulfonio)acetate Chemical compound C[S+](C)CC([O-])=O PSBDWGZCVUAZQS-UHFFFAOYSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- 244000296825 Amygdalus nana Species 0.000 description 2
- 235000003840 Amygdalus nana Nutrition 0.000 description 2
- 241000228212 Aspergillus Species 0.000 description 2
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical class NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 240000001857 Phyllostachys elegans Species 0.000 description 2
- 235000011432 Prunus Nutrition 0.000 description 2
- 244000274883 Urtica dioica Species 0.000 description 2
- 239000006096 absorbing agent Substances 0.000 description 2
- 150000003973 alkyl amines Chemical class 0.000 description 2
- KVYGGMBOZFWZBQ-UHFFFAOYSA-N benzyl nicotinate Chemical compound C=1C=CN=CC=1C(=O)OCC1=CC=CC=C1 KVYGGMBOZFWZBQ-UHFFFAOYSA-N 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 description 2
- 125000002843 carboxylic acid group Chemical group 0.000 description 2
- 239000003093 cationic surfactant Substances 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229940057995 liquid paraffin Drugs 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- IBOBFGGLRNWLIL-UHFFFAOYSA-N n,n-dimethylhexadecan-1-amine oxide Chemical compound CCCCCCCCCCCCCCCC[N+](C)(C)[O-] IBOBFGGLRNWLIL-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 125000002270 phosphoric acid ester group Chemical group 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 230000003658 preventing hair loss Effects 0.000 description 2
- 235000014774 prunus Nutrition 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 239000002453 shampoo Substances 0.000 description 2
- JDSVWTAJRNTSSL-UHFFFAOYSA-M sodium;dodecyl hydrogen phosphate Chemical compound [Na+].CCCCCCCCCCCCOP(O)([O-])=O JDSVWTAJRNTSSL-UHFFFAOYSA-M 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 229940117986 sulfobetaine Drugs 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 1
- QGLWBTPVKHMVHM-KTKRTIGZSA-N (z)-octadec-9-en-1-amine Chemical compound CCCCCCCC\C=C/CCCCCCCCN QGLWBTPVKHMVHM-KTKRTIGZSA-N 0.000 description 1
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 description 1
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- BVXKPGXJOLWHFI-UHFFFAOYSA-N 2-Amino-tetradecanoic acid Chemical compound CCCCCCCCCCCCC(N)C(O)=O BVXKPGXJOLWHFI-UHFFFAOYSA-N 0.000 description 1
- VNUREHWOFQRPGE-UHFFFAOYSA-N 2-[2-dodecyl-1-(2-hydroxyethyl)-4,5-dihydroimidazol-1-ium-1-yl]acetate Chemical compound CCCCCCCCCCCCC1=NCC[N+]1(CCO)CC([O-])=O VNUREHWOFQRPGE-UHFFFAOYSA-N 0.000 description 1
- AMRBZKOCOOPYNY-QXMHVHEDSA-N 2-[dimethyl-[(z)-octadec-9-enyl]azaniumyl]acetate Chemical compound CCCCCCCC\C=C/CCCCCCCC[N+](C)(C)CC([O-])=O AMRBZKOCOOPYNY-QXMHVHEDSA-N 0.000 description 1
- NKFNBVMJTSYZDV-UHFFFAOYSA-N 2-[dodecyl(2-hydroxyethyl)amino]ethanol Chemical compound CCCCCCCCCCCCN(CCO)CCO NKFNBVMJTSYZDV-UHFFFAOYSA-N 0.000 description 1
- LLKXPXLHGVJRIP-UHFFFAOYSA-N 22-methyltricosyl(oxido)azanium Chemical compound CC(C)CCCCCCCCCCCCCCCCCCCCC[NH2+][O-] LLKXPXLHGVJRIP-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
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- 238000011735 C3H mouse Methods 0.000 description 1
- AIRBKHYLADCKMX-UHFFFAOYSA-N CCCCCCCCCCCCC1=NCC[N+]1(CCC([O-])=O)CCO Chemical compound CCCCCCCCCCCCC1=NCC[N+]1(CCC([O-])=O)CCO AIRBKHYLADCKMX-UHFFFAOYSA-N 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
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- 241000699666 Mus <mouse, genus> Species 0.000 description 1
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- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
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- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical class OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical class CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 125000002877 alkyl aryl group Chemical group 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 1
- 150000008052 alkyl sulfonates Chemical class 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
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- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- 229950004580 benzyl nicotinate Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- RZMKWKZIJJNSLQ-UHFFFAOYSA-M carpronium chloride Chemical compound [Cl-].COC(=O)CCC[N+](C)(C)C RZMKWKZIJJNSLQ-UHFFFAOYSA-M 0.000 description 1
- 229950003631 carpronium chloride Drugs 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 229930182912 cyclosporin Natural products 0.000 description 1
- 229960004042 diazoxide Drugs 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 229950010007 dimantine Drugs 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- YVZRXRJDBYHNMK-UHFFFAOYSA-N dodecyl 2-aminoacetate Chemical compound CCCCCCCCCCCCOC(=O)CN YVZRXRJDBYHNMK-UHFFFAOYSA-N 0.000 description 1
- YRIUSKIDOIARQF-UHFFFAOYSA-N dodecyl benzenesulfonate Chemical compound CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 YRIUSKIDOIARQF-UHFFFAOYSA-N 0.000 description 1
- 229940071161 dodecylbenzenesulfonate Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229960002568 ethinylestradiol Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 1
- 229960004068 hexachlorophene Drugs 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 150000004693 imidazolium salts Chemical class 0.000 description 1
- 229940074928 isopropyl myristate Drugs 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 229960003632 minoxidil Drugs 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- BJLVKAGPBSJBSJ-UHFFFAOYSA-N n-dodecyl-n-methyldodecan-1-amine oxide Chemical compound CCCCCCCCCCCC[N+](C)([O-])CCCCCCCCCCCC BJLVKAGPBSJBSJ-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- AHKZTVQIVOEVFO-UHFFFAOYSA-N oxide(2-) Chemical compound [O-2] AHKZTVQIVOEVFO-UHFFFAOYSA-N 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 230000004215 skin function Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- JWZSXZWCWMCYPE-RSAXXLAASA-M sodium;(4s)-4-amino-5-dodecoxy-5-oxopentanoate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)[C@@H](N)CCC([O-])=O JWZSXZWCWMCYPE-RSAXXLAASA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 229960001325 triclocarban Drugs 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9741—Pteridophyta [ferns]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
Abstract
Description
【発明の詳細な説明】
[産業上の利用分野]
本発明は、新規にして、かつ安全なる生薬抽出物または
、生薬抽出物と界面活性剤とを含有することにより、脱
毛防止、発毛、育毛などを促進する効果に優れた養毛料
に関するものである。Detailed Description of the Invention [Industrial Application Field] The present invention contains novel and safe crude drug extracts or crude drug extracts and surfactants to prevent hair loss, hair growth, The present invention relates to a hair nourishing agent that is highly effective in promoting hair growth.
[従来の技術] 従来より、各種薬剤を配合した養毛料が知られている。[Conventional technology] BACKGROUND ART Hair nourishing agents containing various drugs have been known.
例えば、ビタミンB等のビタミン類、メチオニンなどの
アミノ酸類、アセチルコリン誘導体などの血管拡張剤、
紫根エキスなどの抗炎症剤、エストラジオールなどの女
性ホルモン剤、セファランチンなどの皮膚機能亢進剤な
どが配合され、脱毛症の予防及び治療に用いられている
。For example, vitamins such as vitamin B, amino acids such as methionine, vasodilators such as acetylcholine derivatives,
It contains anti-inflammatory agents such as purple root extract, female hormones such as estradiol, and skin function enhancers such as cephalanthine, and is used to prevent and treat alopecia.
しかしながら、従来の養毛料はフケ、カユミ、脱毛など
の予防及び改善に有効で、発毛や育毛を促進するとされ
ているが、いまだ満足すべき効果を発揮するものは得ら
れていない。However, although conventional hair nourishing agents are said to be effective in preventing and improving dandruff, itching, hair loss, etc., and to promote hair growth and hair growth, no product that exhibits satisfactory effects has yet been obtained.
[発明が解決しようとする課題]
本発明者らは脱毛防止、発毛等に有効で、安全性に優れ
た養毛料について、鋭意研究した結果、特定の生薬抽出
物の一種または二種以上、またはこれら特定の生薬抽出
物の一種または二種以上と、特定の界面活性剤とを含有
することによりこの課題を解決しうろことを見出し、本
発明を完成するに至った。[Problems to be Solved by the Invention] As a result of intensive research into hair nourishing agents that are effective for hair loss prevention, hair growth, etc. and excellent in safety, the present inventors have found that one or more specific crude drug extracts, Alternatively, the present inventors have discovered that this problem can be solved by containing one or more of these specific crude drug extracts and a specific surfactant, and have completed the present invention.
[課題を解決するための手段]
すなわち請求項1記載の発明は、アオギリ、アンマロク
、ウバイ、イラクサ、オオクリハラン、オオギ、オウロ
、カッコン、グバク、ケイヒ、ゲドクシ、ゴカヒ、コソ
ウ、ゴミシ、コブシ、コノテガシワ、サンキュウ、チン
ピ、テウチグルミ、セイコウ、サッシヨウ、ドクヨウイ
ッシカ、ショウブ、ショウバク、シラカバ、ニレ、リョ
ウキョウ、リュウヨウ、ヨチシ、ホコッシ、トウヨウ、
ヒャクゴウ、レン、モクセイ、ハンミョウ、フヒョウ、
マクワウリ、ハクヨウ、ハンゲ、バクセン、ハクショウ
、ハクヨウからなる群から選ばれる生薬抽出物の一種又
は二種以上を含有してなる養毛料である。[Means for Solving the Problem] That is, the invention according to claim 1 is directed to the following: Aogiri, Anmaroku, Ubai, Nettle, Ookuriharan, Ogi, Ouro, Kakkon, Gubaku, Keihi, Gedokushi, Gokahi, Kosou, Gomish, Kobushi, Konotegashiwa, Red-bellied, Chinpi, Teuchigurumi, Seikou, Sasshiyou, Dokuyoishika, Calamus, Shobu, Birch, Elm, Ryokyo, Ryuyou, Yochishi, Hokosshi, Touyou,
Hyakugou, Wren, Osmanthus, Hanmyo, Fuhyou,
This is a hair nourishment containing one or more crude drug extracts selected from the group consisting of Cucumber, Cucumber, Cucumber, Baxcens, Cucumber, and Cucumber.
請求項2記載の発明は、請求項1記載の生薬の抽出物の
一種又は二種以上と、アニオン性界面活性剤の一種又は
二種以上と、アニオン界面活性剤以外で分子内に窒素原
子を有する界面活性剤の一種又は二種以上とを含有する
ことを特徴とする養毛料である。The invention according to claim 2 comprises one or more extracts of the crude drug according to claim 1, one or more anionic surfactants, and a nitrogen atom in the molecule other than the anionic surfactant. It is a hair nourishing agent characterized by containing one or more types of surfactants.
請求項3記載の発明は、請求項1記載の生薬の抽出物の
一種又は二種以上と、両性界面活性剤と半極性界面活性
剤の一種または二種以上と、分子内に窒素原子を有する
非イオン界面活性剤の一種または二種以上とを含有する
ことを特徴とする養毛料である。The invention according to claim 3 is characterized in that one or more extracts of the crude drug according to claim 1, one or more amphoteric surfactants and semipolar surfactants, and a nitrogen atom in the molecule. This hair nourishing agent is characterized by containing one or more nonionic surfactants.
請求項4記載の発明は、請求項1記載の生薬の抽出物の
一種又は二種以上と、アミンオキシドとを含有すること
を特徴とする養毛料である。The invention according to claim 4 is a hair nourishing agent, characterized in that it contains one or more extracts of the crude drug according to claim 1 and an amine oxide.
以下、本発明の構成について詳述する。Hereinafter, the configuration of the present invention will be explained in detail.
本発明で用いられる生薬抽出物としては、生薬を溶媒、
例えば、熱水やメタノール、エタノール等の低級アルコ
ールあるいは含水低級アルコールあるいはプロピレング
リコール、1−3ブチレングリコール等の多価アルコー
ルあるいは含水多価アルコール等の含水アルコール等で
抽出して得られる抽出エキスや、その抽出エキスを濃縮
乾燥して得られる抽出物等が挙げられる。本発明におけ
る生薬抽出物の配合量は、養毛料金量中、乾燥物として
o、oos〜10重量%、好ましくは0.01〜5重量
%である。o、oos重量%未満であると、本発明でい
う効果が十分に発揮されず、好ましくない。As the crude drug extract used in the present invention, the crude drug is used as a solvent,
For example, extracts obtained by extraction with hot water, lower alcohols such as methanol, ethanol, hydrous lower alcohols, polyhydric alcohols such as propylene glycol, 1-3 butylene glycol, or hydrous alcohols such as hydrous polyhydric alcohols, Examples include extracts obtained by concentrating and drying the extracted extract. The blending amount of the herbal medicine extract in the present invention is from o,oos to 10% by weight, preferably from 0.01 to 5% by weight, as a dry matter, in the hair nourishment amount. If it is less than o, oos weight%, the effect of the present invention will not be sufficiently exhibited, which is not preferable.
請求項1記載のアニオン性界面活性剤としては、カルボ
ン酸基、スルホン酸基、硫酸エステル基、リン酸エステ
ル基を分子内に一種または二種以上有するアニオン性界
面活性剤が挙げられる。カルボン酸基を有するものとし
ては脂肪酸セッケン、エーテルカルボン酸およびその塩
、アミノ酸と脂肪酸の縮合物等のカルボン酸塩等を、又
、スルホン酸塩を有するものとしては、アルキルスルホ
ン酸塩、スルホコハク酸、エステルスルホン酸塩、アル
キルアリル及びアルキルナフタレンスルホン酸塩、N−
アシルスルホン酸塩、ホルマリン縮合系スルホン酸塩等
を、硫酸エステル基を有するものとしては、硫酸化油、
エステル硫酸塩、アルキル硫酸塩、エーテル硫酸塩、ア
ルキルアリルエーテル硫酸塩、アミド硫酸塩等を、リン
酸エステル基を有するものとしては、アルキルリン酸塩
、アミドリン酸塩、エーテルリン酸塩、アルキルアリル
エーテルリン酸塩等を挙げることができる。これらの中
から一種または二種以上が任意に選択される。The anionic surfactant according to claim 1 includes anionic surfactants having one or more types of carboxylic acid group, sulfonic acid group, sulfuric acid ester group, and phosphoric acid ester group in the molecule. Those with carboxylic acid groups include fatty acid soaps, ether carboxylic acids and their salts, carboxylates such as condensates of amino acids and fatty acids, and those with sulfonates include alkyl sulfonates and sulfosuccinic acids. , ester sulfonates, alkylaryl and alkylnaphthalene sulfonates, N-
Acyl sulfonates, formalin condensation sulfonates, etc. have sulfate ester groups, such as sulfated oils,
Ester sulfates, alkyl sulfates, ether sulfates, alkyl allyl ether sulfates, amide sulfates, etc., those having a phosphoric acid ester group include alkyl phosphates, amide phosphates, ether phosphates, alkylaryl sulfates, etc. Ether phosphates and the like can be mentioned. One or more types are arbitrarily selected from these.
請求項1記載のアニオン性界面活性剤以外で分子内に窒
素原子を有する界面活性剤としては、窒素原子を分子内
に有する両性界面活性剤、半極性界面活性剤、非イオン
性界面活性剤、カチオン性界面活性剤等を挙げることが
できる。両性界面活性剤としては、N、N−ジメチル−
トラウリル−N−カルボキシメチルアンモニウムベタイ
ン、N、N−ジメチル−N−オレイル−N−カルボキシ
メチルアンモニウムベタイン等のカルボキシベタイン、
2−ラウリルート力ルボキシエチル−8−ヒドロキシエ
チルイミダゾリニウムベタイン、2−ラウリル−H−力
シボキシメチル−N−ヒドロキシエチルイミダゾリニウ
ムベタイン等のイミダシリン誘導体、トヤシアルキルー
β−アミノプロピオン酸ソーダ塩、N−ヤシアルキル−
β−イミノジプロピオン酸−ジ−ソーダ塩等のアミノカ
ルボン酸塩、スルホベタイン、アミノベタイン等が挙げ
られる。半極性界面活性剤としては、ジメチルラウリル
アミンオキシド、ビス−(2−とドロキシエチル)ラウ
リルアミンオキシド等が挙げられる。非イオン性界面活
性剤としては、脂肪酸アルカノールアミド、ポリオキシ
エチレン脂肪酸アミド、アルカノールアミンのエステル
、ポリオキシエチレンアルキルアミン等が挙げられる。Examples of surfactants having a nitrogen atom in the molecule other than the anionic surfactant according to claim 1 include amphoteric surfactants having a nitrogen atom in the molecule, semipolar surfactants, nonionic surfactants, Examples include cationic surfactants. As the amphoteric surfactant, N,N-dimethyl-
carboxybetaine such as trauryl-N-carboxymethylammonium betaine, N,N-dimethyl-N-oleyl-N-carboxymethylammonium betaine,
Imidacillin derivatives such as 2-lauryl-hydroxyethyl-8-hydroxyethylimidazolinium betaine, 2-lauryl-H-hydroxymethyl-N-hydroxyethylimidazolinium betaine, cocoalkyl-β-aminopropionic acid sodium salt, N-cocoalkyl-
Examples include aminocarboxylic acid salts such as β-iminodipropionic acid di-soda salt, sulfobetaine, aminobetaine, and the like. Examples of the semipolar surfactant include dimethyl lauryl amine oxide, bis-(2-and droxyethyl) lauryl amine oxide, and the like. Examples of the nonionic surfactant include fatty acid alkanolamide, polyoxyethylene fatty acid amide, alkanolamine ester, polyoxyethylene alkylamine, and the like.
カチオン性界面活性剤としては、脂肪酸アミン塩、アル
キル四級アンモニウム塩、芳香族四級アンモニウム塩、
ピリジウム塩、イミダゾリウム塩等が挙げられる。これ
らの中から一種又は二種以上が任意に選択きれる。Examples of cationic surfactants include fatty acid amine salts, alkyl quaternary ammonium salts, aromatic quaternary ammonium salts,
Examples include pyridium salts and imidazolium salts. One or more types can be arbitrarily selected from these.
請求項2記載の両性界面活性剤としては、N、N−ジメ
チル−N−ラウリル−N−カルボキシメチルアンモニウ
ムベタイン、N、N−ジメチル−H−オレイル−N−力
ルボキシメチルアンモニウムベタイン等のカルボキシベ
タイン、2−ラウリル−N−カルボキシエチル−N−ヒ
ドロキシエチルイミダゾリニウムベタイン、2−ラウリ
ル−N−カルボキシメチル−N−ヒドロキシエチルイミ
ダゾリニウムベタイン等のイミダシリン誘導体、トヤシ
アルキルーβ−アミノプロピオン酸ソーダ塩、トヤシア
ルキルーβ−イミノジプロピオン酸−ジ−ソーダ塩等の
アミノカルボン酸塩、スルホベタイン、アミノベタイン
等が挙げられる。The amphoteric surfactant according to claim 2 is a carboxylic surfactant such as N,N-dimethyl-N-lauryl-N-carboxymethylammonium betaine, N,N-dimethyl-H-oleyl-N-carboxymethylammonium betaine, etc. Imidacillin derivatives such as betaine, 2-lauryl-N-carboxyethyl-N-hydroxyethylimidazolinium betaine, 2-lauryl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, toyacyalkyl-β-aminopropionic acid sodium salt , aminocarboxylic acid salts such as toyashalkyl-β-iminodipropionic acid di-soda salt, sulfobetaine, aminobetaine, and the like.
請求項2記載の半極性界面活性剤としては、ジメチルラ
ウリルアミンオキシド、ビス−(2−ヒドロキシエチル
)ラウリルアミンオキシド等が挙げられる。Examples of the semipolar surfactant according to claim 2 include dimethyl lauryl amine oxide, bis-(2-hydroxyethyl) lauryl amine oxide, and the like.
請求項2記載の非イオン性界面活性剤としては、脂肪酸
アルカノールアミド、ポリオキシエチレン脂肪酸アミド
、アルカノールアミンのエステル、ポリオキシエチレン
アルキルアミン等が挙げられる。Examples of the nonionic surfactant according to claim 2 include fatty acid alkanolamide, polyoxyethylene fatty acid amide, alkanolamine ester, polyoxyethylene alkylamine, and the like.
請求項3記載のアミンオキシドとしては、下記一般式(
A)〜(C)のものが挙げられる。The amine oxide according to claim 3 has the following general formula (
Examples are A) to (C).
R1
R2−N−+O(A)
(式中R1、R2およびR3は炭素原子数1がら24の
直鎖または分枝の飽和又は不飽和の炭化水素基を表わし
、R1、R2、R3のうち少なくとも1個は炭素原子数
8以上の直鎖または分枝の飽和又は不飽和の炭化水素基
を表わす。)
一般式(A)で表わされるアミンオキシドの具体例とし
ては、ジメチルラウリルアミンオキシド、ジメチルミリ
スチルアミンオキシド、ジメチルセチルアミンオキシド
、ジメチルステアリルアミンオキシド、ジメチルセチル
アミンオキシド、ジメチルベヘニルアミンオキシド、メ
チルジラウリルアミンオキシドなどが挙げられる。R1 R2-N-+O(A) (In the formula, R1, R2 and R3 represent a straight chain or branched saturated or unsaturated hydrocarbon group having 1 to 24 carbon atoms, and at least (One represents a straight chain or branched saturated or unsaturated hydrocarbon group having 8 or more carbon atoms.) Specific examples of the amine oxide represented by the general formula (A) include dimethyl lauryl amine oxide, dimethyl myristyl Examples include amine oxide, dimethylcetylamine oxide, dimethylstearylamine oxide, dimethylcetylamine oxide, dimethylbehenylamine oxide, and methyldilaurylamine oxide.
Cf(2CH20H
R4N→0 (B)C82
CR20H
(式中R4は炭素原子数8から24の直鎖または分枝の
飽和又は不飽和の炭化水素基を表わす。) H3
R5−(OCH2CH2)n N→0 (C
)H3
(式中R5は炭素原子数8から24の直鎖または分枝の
飽和又は不飽和の炭化水素基を表わし、nは1から5の
整数を表わす。)
本発明においては、これらアミンオキシドの一種または
二種以上が任意に選択され、用いられる。Cf(2CH20H R4N→0 (B)C82
CR20H (In the formula, R4 represents a straight chain or branched saturated or unsaturated hydrocarbon group having 8 to 24 carbon atoms.) H3 R5-(OCH2CH2)n N→0 (C
)H3 (In the formula, R5 represents a straight chain or branched saturated or unsaturated hydrocarbon group having 8 to 24 carbon atoms, and n represents an integer of 1 to 5.) In the present invention, these amine oxides One or more of these are arbitrarily selected and used.
請求項1記載のアニオン性界面活性剤と、アニオン性界
面活性剤以外で分子内に窒素原子を有する界面活性剤の
合計配合量は、養毛料金量中0.001〜10重量%が
好ましく、さらに好ましくは0.01〜5重量%である
。また、アニオン性界面活性剤と、アニオン性界面活性
剤以外で分子内に窒素原子を有する界面活性剤との割合
は、分子比で20:1〜1:20が好ましく、ざらに好
ましくは10:1〜1:10である。The total amount of the anionic surfactant according to claim 1 and a surfactant other than the anionic surfactant having a nitrogen atom in the molecule is preferably 0.001 to 10% by weight based on the amount of hair nourishing fee. More preferably, it is 0.01 to 5% by weight. Further, the ratio of the anionic surfactant to the surfactant other than the anionic surfactant having a nitrogen atom in the molecule is preferably 20:1 to 1:20 in molecular ratio, more preferably 10: The ratio is 1 to 1:10.
請求項2記載の両性界面活性剤と半極性界面活性剤の一
種または二種以上と、分子内に窒素原子を有する非イオ
ン性界面活性剤の一種漬たは二種以上の合計配合量は、
養毛料全量中0.001〜10重量%が好ましく、ざら
に好まし、くは0.01〜5重量%である。また、両性
界面活性剤と半極性界面活性剤の一種または二種以上と
、分子内に窒素原子を有する非イオン性界面活性剤の一
種または二種以上との割合は、分子比で20=1〜1:
20が好ましく、さらに好ましくは10:1〜1:10
である。The total blending amount of one or more of the amphoteric surfactant and semipolar surfactant according to claim 2, and one or more of the nonionic surfactant having a nitrogen atom in the molecule is:
It is preferably 0.001 to 10% by weight, most preferably 0.01 to 5% by weight, based on the total amount of the hair nourishing agent. In addition, the ratio of one or more amphoteric surfactants and semipolar surfactants to one or more nonionic surfactants having a nitrogen atom in the molecule is 20 = 1. ~1:
20 is preferable, more preferably 10:1 to 1:10
It is.
請求項3記載のアミンオキシドの配合量は、養毛料全量
中の0.0001〜20重量%が好ましい。配合量が0
.0001重量%未満では十分な養毛効果が得られず、
20重量%を越えると製剤上または皮膚刺激の上からも
好ましくない。The amount of the amine oxide according to claim 3 is preferably 0.0001 to 20% by weight based on the total amount of the hair nourishment. Blend amount is 0
.. If it is less than 0001% by weight, sufficient hair nourishing effect cannot be obtained,
If it exceeds 20% by weight, it is undesirable from the standpoint of formulation and skin irritation.
本発明に係る養毛料には、上記必須成分のほかに、通常
養毛料に用いられる汎用成分、例えばビタミンB6、ビ
タミンE及びその誘導体、ビオチン等のビタミン類、パ
ントテン酸及びその誘導体、グリチルレチン酸及びその
誘導体、ニコチン酸ベンジル等のニコチン酸エステル類
、サイクロスポリン類、塩化カルプロニウム、セファラ
ンチン、オキセンドロン、ジアゾキシド、ミノキシジル
、エチニルエストラジオールなどの発毛剤又は発毛助剤
、ヒノキチオール、ヘキサクロロフェン、フェノール、
ベンザルコニウムクロリド、セチルピリジニウムクロリ
ド、ウンデシレン酸、トリクロロカルバニリド及びピチ
オノールなどの抗菌剤、メントールなどの清涼剤、サリ
チル酸、亜鉛及びその誘導体、乳酸及びそのアルキルエ
ステルなどの薬剤、クエン酸等の有機酸類、アルギニン
等のアミノ酸類、オリーブ油、スクワラン、流動パラフ
ィン、イソプロピルミリステート、高級脂肪酸、高級ア
ルコールなどの油分、グリセリン、プロピレングリコー
ル等の多価アルコール、香料、酸化防止剤、紫外線吸収
剤、色素、エタノール、ベンジルアルコール、イソプロ
ピルアルコール等のアルコール類、水、保湿剤、増粘剤
などが本発明の効果を損なわない範囲で適宜配合するこ
とができる。In addition to the above-mentioned essential ingredients, the hair nourishment according to the present invention includes general-purpose ingredients normally used in hair nourishing agents, such as vitamin B6, vitamin E and its derivatives, vitamins such as biotin, pantothenic acid and its derivatives, glycyrrhetinic acid, and Derivatives thereof, nicotinic acid esters such as benzyl nicotinate, cyclosporins, carpronium chloride, cephalanthine, oxendrone, diazoxide, minoxidil, hair growth aids such as ethinyl estradiol, hinokitiol, hexachlorophene, phenol,
Antibacterial agents such as benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichlorocarbanilide and pithionol, cooling agents such as menthol, drugs such as salicylic acid, zinc and its derivatives, lactic acid and its alkyl esters, and organics such as citric acid. Acids, amino acids such as arginine, oils such as olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids, higher alcohols, polyhydric alcohols such as glycerin and propylene glycol, fragrances, antioxidants, ultraviolet absorbers, pigments, Alcohols such as ethanol, benzyl alcohol, and isopropyl alcohol, water, humectants, thickeners, and the like can be appropriately blended within the range that does not impair the effects of the present invention.
本発明の養毛料は、液状、乳液、軟膏、クリーム、ゲル
、エアゾールなど外皮に適用できる剤型のものであれば
いずれでもよく、トニック、コンディショナー スカル
プトリートメント、シャンプー、リンスなどの形態で用
いられる。The hair nourishing agent of the present invention may be in any form as long as it can be applied to the outer skin, such as liquid, emulsion, ointment, cream, gel, aerosol, etc., and is used in the form of tonic, conditioner, scalp treatment, shampoo, rinse, etc.
[実施例1
次に、実施例により本発明について詳細に説明する。本
発明はこれらにより限定されるものではない。配合量は
重量%である。[Example 1] Next, the present invention will be explained in detail with reference to Examples. The present invention is not limited to these. The blending amount is in weight%.
i且効−果JΣ測−Z法(マウスでの育毛効果測定)雄
のC3Hマウス(生後60日)を用い、小川らの方法[
(Normal and Abnormal Epid
ermal Dif−ferentiation )
M、5eiji and 1.A、Bernstein
m集束大出版会]に従い実験を行なった。すなわち、
マウスの背部上を約2X4cmの大きさに剃り、翌日よ
り1日1回ずつ連日サンプル塗布を行ない、毛再生が始
まった部分の面積比の変化を求め、毛再生の早さの比較
を行なった。サンプルは各生薬抽出液の乾燥物を75%
エタノールに攪拌溶解し、これに界面活性剤を添加、溶
解しサンプルとした。試験には対照として75%エタノ
ールを用いた。各試料ともマウス10匹ずつを用い、そ
の変化率の平均値を求めた。20日後毛再生面積の結果
を百分率にて表−1に示した。I and effect JΣ measurement-Z method (measuring hair growth effect in mice) Using male C3H mice (60 days old), Ogawa et al.'s method [
(Normal and Abnormal Epid
ermal Dif-ferentiation)
M, 5eiji and 1. A.Bernstein
The experiment was carried out in accordance with M Shokushu Dai Shuppankai]. That is,
The top of the mouse's back was shaved to a size of approximately 2 x 4 cm, and samples were applied once a day starting from the next day. Changes in the area ratio of the area where hair regeneration had started were determined and the speed of hair regeneration was compared. . The sample is 75% dry matter of each crude drug extract.
The sample was dissolved in ethanol with stirring, and a surfactant was added and dissolved therein to prepare a sample. 75% ethanol was used as a control in the test. Ten mice were used for each sample, and the average value of the rate of change was determined. The results of the hair regeneration area after 20 days are shown in Table 1 as a percentage.
比較例 1
(1)75%エタノール
比較例 2
(1)センブリの
50%エタノール抽出物(乾燥物)
(2)75%エタノール
0.2
残余
比較例 3
(1)トウキの
70%エタノール抽出物(乾燥物)
(2)75%エタノール
0.2
残余
比較例 4
(1)クラン50%エタノール抽出物(乾燥物)0.2
(2)75%エタノール
残余
(2)75%エタノール
残余
比較例 5
(1)チクセツニンジンの
50%エタノール抽出物(乾燥物)
(2)75%エタノール
0.2
残余
実施例 1
(1)アオギリの
50%エタノール抽出物(乾燥物)
(2)75%エタノール
0.2
残余
実施例 2
(1)ハクヨウの
70%エタノール抽出物(乾燥物)
(2)75%エタノール
0.2
残余
実施例 3
(1)モクセイの
50%エタノール抽出物(乾燥物)
0.2
実施例 4
(1)ジメチルラウリルアミンオキシド(2)アオギリ
の
50%エタノール抽出物(乾燥物)
(3)75%エタノール
0.1
0.1
残余
実施例 5
(1)ジメチルステアリルアミンオキシド(2)ハクヨ
ウのメタノール抽出物(乾燥物)(3)75%エタノー
ル
0.1
0.1
残余
実施例 6
(1)ジメチルラウリルアミンオキシド(2)モクセイ
の
50%エタノール抽出物(乾燥物)
(3)75%エタノール
0.1
0.1
残余
実施例 7
(1)ジメチルステアリルアミンオキシド(2)ホコッ
シの1.3−ブチレン
グリコール抽出物(乾燥物)
(3)75%エタノール
実施例 8
(1)ドデシルベンゼンスルホネート
(2)ラウリルジメチルアミンオキシド(3)ハクコラ
の
70%エタノール抽出物(乾燥物)
(4)75%エタノール
実施例 9
(1)ラウリル硫酸ナトリウム
(2)ジメチルラウリルアミンオキシド(3)ヨヂシの
エタノール抽出物(乾燥物)(4)75%エタノール
実施例 10
(1)ジメチルステアリルアミンオキシド0.1
0.1
残余
0.05
0.05
0.1
残余
0.04
0.06
0.1
残余
0.075
(2)ラウリル硫酸ナトリウム
(3)シラカバの熱水抽出物(乾燥物)(4)75%エ
タノール
実施例 11
(1)ジメチルステアリルアミンオキシ(2)モノナト
リウムラウリル
フォスフェート
(3)ケイヒの
70%エタノール抽出物(乾燥物)
(4)75%エタノール
ド
実施例 12
(1)ジメチルステアリルアミンオキシド(2)ラウリ
ルメチルタウリンナトリウム(3)オオクリハランの
メタノール抽出物(乾燥物)
(4)リョウキョウの熱水抽出物(乾燥物)(5)75
%エタノール
0.025
0.1
残余
0.15
0.05
0.05
残余
0.03
0.02
0.1
0.05
残余
実施例 13
(1)ラウリルアミノ酢酸ベタイン
(2)ラウロイルジェタノールアミド
(3)ハンゲの
70%エタノール抽出物(乾燥物)
(4)フヒョウの
メタノール抽出物(乾燥物)
(5)テウヂグルミの
プロパツール抽出物(乾燥物)
(6)75%エタノール
実施例 14
(1)ジメチルラウリルアミンオキシド(2)モノナト
リウム
ラウリルフォスフェート
(3)グバクの
70%エタノール抽出物(乾燥物)
(4)チンどのメタノール抽出物(乾燥物)(5)グカ
ヒの
プロパツール抽出物(乾燥物)
0.03
0.02
0.05
0.05
0.05
残余
0.04
0.01
0.05
0.05
0.05
(6)75%エタノール
実施例 15
(1)ジメチルラウリルアミンオキシド(2)ラウリル
メチルタウリンナトリウム(3)ウバイの
70%エタノール抽出物(乾燥物)
(4)アンマロクの
メタノール抽出物(乾燥物)
(5)オオギの
プロパツール抽出物(乾燥物)
(6)75%エタノール
実施例 16
(1)ラウリルアミノ酢酸ベタイン
(2)ラウロイルジェタノールアミド
(3)イラクサの
70%エタノール抽出物(乾燥物)
(4)ゲドクシの
メタノール抽出物(乾燥物)
残余
0.03
0.02
0.05
0.05
0.05
残余
0.03
0.02
0.05
0.05
(5)バクセンの
プロパツール抽出物(乾燥物)
(6)75%エタノール
実施例 17
(1)ジメチルオレイルアミンオキシド(2)ラウロイ
ルジェタノールアミド
(3)マクワウリの
70%エタノール抽出物(乾燥物)
(4)ハクショウの
メタノール抽出物(乾燥物)
(5)ヒャクゴウの
プロパツール抽出物(乾燥物)
(6)75%エタノール
実施例 18
(1)ジメチルラウリルアミンオキシド(2)ラウリル
硫酸ナトリウム
(3)サンキュウの
70%エタノール抽出物(乾燥物)
0.05
残余
(4)サッシヨウの
メタノール抽出物(乾燥物)
(5)ショウブの
プロパツール抽出物(乾燥物)
(6)75%エタノール
0.05
0.05
残余
0.03
0、O2
0,05
0,05
0,05
残余
0.05
実施例 19
(1)ジメチルオレイルアミンオキシド(2)モノナト
リウム
ラウリルグルタメート
(3)トウヨウの
70%エタノール抽出物(乾燥物)
(4)セイコウの
メタノール抽出物(乾燥物)
(5)コノテガシワの
プロパツール抽出物(乾燥物)
(6)75%エタノール
0.06
0.01
0.04
0.04
0.05
残余
0.01
0.04
実施例20 ヘアートニック
以下に示す組成のトニックを調製して実使用にてフケ、
発毛、脱毛等の症状に対する効果を検討した。Comparative example 1 (1) 75% ethanol Comparative example 2 (1) 50% ethanol extract (dry product) of Aspergillus sp. (dry product) (2) 75% ethanol 0.2 Residue Comparative Example 4 (1) Crane 50% ethanol extract (dry product) 0.2
(2) 75% ethanol residual (2) 75% ethanol residual Comparative Example 5 (1) 50% ethanol extract of Panax ginseng (dried product) (2) 75% ethanol 0.2 Residue Example 1 (1) Aogiri (2) 75% ethanol 0.2 Residue Example 2 (1) 70% ethanol extract (dry product) of Prunus japonicus (dry product) (2) 75% ethanol 0.2 Residue Example 3 (1) 50% ethanol extract of Osmanthus (dry product) 0.2 Example 4 (1) Dimethyl laurylamine oxide (2) 50% ethanol extract of Ossiflora (dry product) (3) 75% ethanol 0.1 0.1 Remaining Example 5 (1) Dimethylstearylamine oxide (2) Methanol extract of Hakuyo (dry product) (3) 75% ethanol 0.1 0.1 Remaining Example 6 (1) Dimethyllaurylamine oxide ( 2) 50% ethanol extract (dry product) of Osmanthus japonica (3) 75% ethanol 0.1 0.1 Remaining Example 7 (1) Dimethylstearylamine oxide (2) 1,3-butylene glycol extract of Osmanthus japonica ( Dry product) (3) 75% ethanol Example 8 (1) Dodecylbenzene sulfonate (2) Lauryl dimethylamine oxide (3) 70% ethanol extract of Hakukola (dry product) (4) 75% ethanol Example 9 (1 ) Sodium lauryl sulfate (2) Dimethyllaurylamine oxide (3) Ethanol extract of Yojishi (dry product) (4) 75% ethanol Example 10 (1) Dimethylstearylamine oxide 0.1 0.1 Remaining 0.05 0 .05 0.1 Remaining 0.04 0.06 0.1 Remaining 0.075 (2) Sodium lauryl sulfate (3) Birch birch hot water extract (dried product) (4) 75% ethanol Example 11 (1) Dimethylstearylamine oxy (2) Monosodium lauryl phosphate (3) 70% ethanol extract of cinnamon bark (dry product) (4) 75% ethanold Example 12 (1) Dimethylstearylamine oxide (2) Sodium lauryl methyl taurate (3) Methanol extract of Ookuriharan (dry product) (4) Hot water extract of Ryokyo (dry product) (5) 75
% ethanol 0.025 0.1 Residue 0.15 0.05 0.05 Residue 0.03 0.02 0.1 0.05 Residue Example 13 (1) Lauryl aminoacetic acid betaine (2) Lauroyl jetanolamide ( 3) 70% ethanol extract (dry product) of Hangae (4) Methanol extract (dry product) of Fuhyeopsis (5) Proper tool extract (dry product) of Teujigurumi (6) 75% ethanol Example 14 (1) Dimethyl laurylamine oxide (2) Monosodium lauryl phosphate (3) 70% ethanolic extract of Gubaku (dry product) (4) Methanol extract of Chindo (dry product) (5) Propatur extract of Gukahi (dry product) ) 0.03 0.02 0.05 0.05 0.05 Remaining 0.04 0.01 0.05 0.05 0.05 (6) 75% ethanol Example 15 (1) Dimethyllaurylamine oxide (2 ) Sodium lauryl methyl taurate (3) 70% ethanol extract of Ubai (dry product) (4) Methanol extract of Ammarok (dry product) (5) Propateur extract of Aspergillus orientalis (dry product) (6) 75% ethanol Example 16 (1) Betaine lauryl aminoacetate (2) Lauroylgetanolamide (3) 70% ethanolic extract of stinging nettle (dry product) (4) Methanol extract of Japanese nettle (dry product) Remaining 0.03 0.02 0.05 0.05 0.05 Remaining 0.03 0.02 0.05 0.05 (5) Baxen propatool extract (dried product) (6) 75% ethanol Example 17 (1) Dimethyloleylamine oxide (2) Lauroylgetanolamide (3) 70% ethanolic extract of Oriental melon (dried) (4) Methanol extract of Oriental chinensis (dried) (5) Propatur extract of Oriental chinensis (dried) (6) 75 % Ethanol Example 18 (1) Dimethyllaurylamine oxide (2) Sodium lauryl sulfate (3) 70% ethanol extract of Sankyu (dry product) 0.05 Remaining amount (4) Methanol extract of Sasshiyou (dry product) (5 ) Calamus propator extract (dried) (6) 75% ethanol 0.05 0.05 Remaining 0.03 0, O2 0.05 0.05 0.05 Remaining 0.05 Example 19 (1) Dimethyl Oleylamine oxide (2) Monosodium lauryl glutamate (3) 70% ethanolic extract (dry product) of Porphyra sativa (dry product) (4) Methanol extract (dry product) of Seiko prunus (5) Propatur extract (dry product) (6) ) 75% ethanol 0.06 0.01 0.04 0.04 0.05 Remaining 0.01 0.04 Example 20 Hair tonic A tonic with the composition shown below was prepared and used to treat dandruff,
The effects on symptoms such as hair growth and hair loss were investigated.
フケ、発毛、脱毛等の症状を呈する20名の男性(年齢
24〜60才)に1日1〜2回゛、1〜5 mLずつ4
力月にわたって塗布し、表−2の結果を得た。Administer 1 to 5 mL 1 to 2 times a day to 20 men (age 24 to 60) with symptoms such as dandruff, hair growth, and hair loss.
The coating was applied for several months, and the results shown in Table 2 were obtained.
フケ、発毛及−び脱毛等の症状に優れていた。It was excellent in treating symptoms such as dandruff, hair growth, and hair loss.
表−1から明らかなように各実施例において毛の再生に
対する効果が認められた。As is clear from Table 1, the effect on hair regeneration was observed in each Example.
(1)オウロの
70%エタノール抽出物(乾燥物)
(2)カッコンの
90%エタノール抽出物(乾燥物)
(3)ゴミシのメタノール抽出物(乾燥物)(4)ジメ
チルラウリルアミンオキシド(5)ラウリル硫酸ナトリ
ウム
(6)プロピレングリコール
(7)ヒアルロン酸ナトリウム
(8)75%エタノール
0.05
1.0
0.5
0.3
0.05
5.0
0.01
残余
前記の表−2においては下記基準により効果判定を行っ
た。(1) 70% ethanol extract of Ouro (dry product) (2) 90% ethanol extract of Kakkon (dry product) (3) Methanol extract of Gomishi (dry product) (4) Dimethyllaurylamine oxide (5) Sodium lauryl sulfate (6) Propylene glycol (7) Sodium hyaluronate (8) 75% ethanol 0.05 1.0 0.5 0.3 0.05 5.0 0.01 The remainder is as follows in Table 2 above. Effects were evaluated based on criteria.
1、フケ防止効果テスト
「無効」とは治療にも拘らず何らの改善もみられないも
の。1. Dandruff prevention effect test ``Ineffective'' means that no improvement is seen despite treatment.
「有効」とはフケの発生が減少したもの。"Effective" means that the occurrence of dandruff has been reduced.
「著効」とはフケの発生が止まったもの。"Remarkable effect" means that dandruff has stopped occurring.
2、発毛効果テスト
「無効」とは治療にも拘らず何らの改善もみられないも
の。2. Hair growth effect test ``Ineffective'' means that no improvement is seen despite treatment.
「有効」とは脱毛部の2/3以上に毛の新生が認やられ
るもの。"Effective" means that new hair growth is observed in 2/3 or more of the hair loss area.
「著効」とは脱毛部に毛が生えそろったもの。``Remarkable effect'' means that hair has grown in the hair removal area.
3、脱毛効果テスト
「無効」とは治療にも拘らず何らの改善もみられないも
の。3. Hair removal effect test ``Ineffective'' means that no improvement is seen despite treatment.
「有効」とは脱毛の進行が減少したもの。"Effective" means that the progression of hair loss has been reduced.
「著効」とは脱毛が止まったもの。“Remarkable response” means that hair loss has stopped.
実施例21 ヘアートニック
(1)コブシの
メタノール抽出物(乾燥物)
(2)コノテガシワの
80%エタノール抽出物(乾燥物)
0.05
0.05
(3)コソウの1.3−ブチレン
グリコール抽出物(乾燥物)
(4)ショウバクの
90%エタノール抽出物(乾燥物)
(5)ドクヨウイッシカの
熱水抽出物(乾燥物)
(6)ニレの
70%エタノール抽出物(乾燥物)
(7)ポリオキシエチレン(8モル)
オレイルアルコールエーテル
(8)1.3−ブチレングリコール
(9)60%エタノール
実施例22 シャンプー
(1)ココイルメチルタウリンナトリウム(2)ラウリ
ルジメチル
アミノ酢酸ベタイン
(3)ラウリン酸ジェタノールアミド
(4)エチレングリコール脂肪酸エステル(5)プロピ
レングリコール
0.05
0.05
0.05
0.05
0.05
0.05
残余
(6)リュウヨウの
70%エタノール抽出物(乾燥物)
(7)レンの
50%エタノール抽出物(乾燥物)
(8)ハンミョウの
メタノール抽出物(乾燥物)
(9)アオギリのプロピレン
グリフール抽出物(乾燥物)
(10)エデト酸2ナトリウム
(11)香料
(12)精製水
1.0
1.0
1.0
0.2
0.1
適量
残部
6.0
8.0
4.0
1.5
2.0
実施例23 リンス
(1)ステアリルトリメチル
アンモニウムクロリド
(2)セチルアルコール
(3)シリコン油
(4)ポリオキシエチレン(10モル)オレイルアルコ
ールエーテル
(5)グリセリン
1.5
2.0
3.0
1.0
5.0
(6)ウバイのメタノール抽出物(乾燥物)(7)バク
センの
メタノール抽出物(乾燥物)
(8)ホコッシの熱水抽出物(乾燥物)(9)フヒョウ
の
70%エタノール抽出物(乾燥物)
(10)精製水
(11)防腐剤
(12)紫外線吸収剤
0.5
0.5
1.0
1.0
84.0
適量
適量
実施例24 ヘアクリーム
(1)ミツロウ
(2)ワセリン
(3)流動パラフィン
(4)ポリオキシエチレン(5モル)
ステアリン酸エステル
(5)ポリオキシエチレン(6モル)
オレイルアルコールエーテル
(6)ゴカヒの
90%プロパツール抽出物(乾燥物)
3.0
15.0
42.0
3.0
1.0
0.3
(7)リョウキョウの
50%メタノール抽出物(乾燥物)
(8)チンどの
70%エタノール抽出物(乾燥物)
(9)精製水
(10)香料
(11)防腐剤
0.2
0.4
35.1
適量
適量
実施例21〜24は、いずれも養毛効果に優れていた。Example 21 Hair tonic (1) Methanol extract of Kobushu (dry product) (2) 80% ethanol extract of Kobushu (dry product) 0.05 0.05 (3) 1.3-butylene glycol extract of Kosou (Dried product) (4) 90% ethanol extract of P. elegans (dry product) (5) Hot water extract of P. elegans (dry product) (6) 70% ethanol extract of Elm (dry product) (7) Polyoxy Ethylene (8 moles) Oleyl alcohol ether (8) 1,3-butylene glycol (9) 60% ethanol Example 22 Shampoo (1) Sodium cocoyl methyl taurate (2) Betaine lauryldimethylaminoacetate (3) Lauric acid jetanolamide (4) Ethylene glycol fatty acid ester (5) Propylene glycol 0.05 0.05 0.05 0.05 0.05 0.05 Residue (6) 70% ethanol extract (dry product) of Ryuyou (7) Ren 50% ethanol extract (dry product) (8) Methanol extract of Hanmyo (dry product) (9) Propylene glyfur extract of Aspergillus perilla (dry product) (10) Disodium edetate (11) Flavor (12) Purification Water 1.0 1.0 1.0 0.2 0.1 Appropriate amount remaining 6.0 8.0 4.0 1.5 2.0 Example 23 Rinse (1) Stearyltrimethylammonium chloride (2) Cetyl alcohol ( 3) Silicone oil (4) Polyoxyethylene (10 mol) Oleyl alcohol ether (5) Glycerin 1.5 2.0 3.0 1.0 5.0 (6) Methanol extract of Ubay (dried) (7 ) Methanol extract of Baxen (dried product) (8) Hot water extract of Hokossi (dry product) (9) 70% ethanol extract of Fuhyo (dry product) (10) Purified water (11) Preservative (12) UV absorber 0.5 0.5 1.0 1.0 84.0 Appropriate amount Appropriate amount Example 24 Hair cream (1) Beeswax (2) Vaseline (3) Liquid paraffin (4) Polyoxyethylene (5 moles) Stearic acid Ester (5) Polyoxyethylene (6 moles) Oleyl alcohol ether (6) 90% propatool extract of Gocahi (dried) 3.0 15.0 42.0 3.0 1.0 0.3 (7) 50% methanol extract (dry product) of chinensis (8) 70% ethanol extract (dry product) of chinensis (9) Purified water (10) Flavor (11) Preservative 0.2 0.4 35.1 Appropriate amount Appropriate amount Examples 21 to 24 were all excellent in hair-nourishing effects.
[発明の効果]
本発明の養毛料は、特定の生薬抽出物または、特定の生
薬抽出物と特定の界面活性剤とを含有することにより、
従来の養毛料よりも著しく優れた各種の性質(例えば、
発毛、育毛、脱毛防止効果等)を示す。[Effect of the invention] The hair nourishment of the present invention contains a specific crude drug extract or a specific crude drug extract and a specific surfactant, thereby achieving the following effects:
Various properties that are significantly superior to conventional hair nourishing agents (e.g.
hair growth, hair growth, hair loss prevention effects, etc.).
特許出願人 株式会社 資生堂Patent applicant: Shiseido Co., Ltd.
Claims (4)
クリハラン、オオギ、オウロ、カッコン、グバク、ケイ
ヒ、ゲドクシ、ゴカヒ、コソウ、ゴミシ、コブシ、コノ
テガシワ、サンキュウ、チンピ、テウチグルミ、セイコ
ウ、サッシヨウ、ドクヨウイッシカ、ショウブ、ショウ
バク、シラカバ、ニレ、リョウキョウ、リュウヨウ、ヨ
チシ、ホコツシ、トウヨウ、ヒャクゴウ、レン、モクセ
イ、ハンミョウ、フヒョウ、マクワウリ、ハクコウ、ハ
ンゲ、バクセン、ハクショウ、ハクヨウからなる群から
選ばれる生薬抽出物の一種又は二種以上を含有してなる
養毛料。(1) Aogiri, Anmaroku, Ubai, Nettle, Ookuriharan, Oogi, Ouro, Kakkon, Gubaku, Keihi, Gedokushi, Gokahi, Kosou, Gomishi, Kobushi, Konotegashiwa, Sankyu, Chimpi, Teuchigurumi, Seiko, Sasshiyou, Dokuyouishika, Calamus, Shobu one or two crude drug extracts selected from the group consisting of , birch, elm, chinensis, chinensis, yochishi, hokotsushi, trumpet, hyakugo, wren, osmanthus, chinensis, chinensis, chinensis, chinensis, hange, baxcens, chinensis, and chinensis. A hair nourishment containing seeds or more.
クリハラン、オオギ、オウロ、カッコン、グバク、ケイ
ヒ、ゲドクシ、ゴカヒ、コソウ、ゴミシ、コブシ、コノ
テガシワ、サンキュウ、チンピ、テウチグルミ、セイコ
ウ、サッシヨウ、ドクヨウイッシカ、ショウブ、ショウ
バク、シラカバ、ニレ、リョウキョウ、リュウヨウ、ヨ
チシ、ホコツシ、トウヨウ、ヒャクゴウ、レン、モクセ
イ、ハンミョウ、フヒョウ、マクワウリ、ハクコウ、ハ
ンゲ、バクセン、ハクショウ、ハクヨウからなる群から
選ばれる生薬の抽出物の一種又は二種以上と、アニオン
性界面活性剤の一種又は二種以上と、アニオン界面活性
剤以外で分子内に窒素原子を有する界面活性剤の一種又
は二種以上とを含有することを特徴とする養毛料。(2) Aogiri, Anmaroku, Ubai, Nettle, Ookuriharan, Oogi, Ouro, Kakkon, Gubaku, Keihi, Gedokushi, Gokahi, Kosou, Gomishi, Kobushi, Konotegashiwa, Sankyu, Chimpi, Teuchigurumi, Seikou, Sasshiyou, Dokuyouishika, Calamus, Shobu , birch, elm, chinensis, ryuyou, yochishi, hokotsushi, toyo, hyakugo, wren, osmanthus, japonica, japonica, japonica, cypress, hange, baxcens, cypress, cypress, or an extract of a herbal medicine selected from the group consisting of A surfactant containing two or more types of surfactants, one or more types of anionic surfactants, and one or more types of surfactants having a nitrogen atom in the molecule other than anionic surfactants. Hair fee.
クリハラン、オオギ、オウロ、カッコン、グバク、ケイ
ヒ、ゲドクシ、ゴカヒ、コソウ、ゴミシ、コブシ、コノ
テガシワ、サンキュウ、チンピ、テウチグルミ、セイコ
ウ、サッシヨウ、ドクヨウイッシカ、ショウブ、ショウ
バク、シラカバ、ニレ、リョウキョウ、リュウヨウ、ヨ
チシ、ホコツシ、トウヨウ、ヒャクゴウ、レン、モクセ
イ、ハンミョウ、フヒョウ、マクワウリ、ハクコウ、ハ
ンゲ、ハクセン、ハクショウ、ハクヨウからなる群から
選ばれる生薬の抽出物の一種又は二種以上と、両性界面
活性剤と半極性界面活性剤の一種または二種以上と、分
子内に窒素原子を有する非イオン界面活性剤の一種また
は二種以上とを含有することを特徴とする養毛料。(3) Aogiri, Anmaroku, Ubai, Nettle, Ookuriharan, Oogi, Ouro, Kakkon, Gubaku, Keihi, Gedokushi, Gokahi, Kosou, Gomishi, Kobushi, Konotegashiwa, Sankyu, Chimpi, Teuchigurumi, Seiko, Sasshiyou, Dokuyouishika, Calamus, Shoubaku , birch, elm, chinensis, ryuyou, yochishi, hokotsushi, trumpet, hyakugo, wren, osmanthus, japonica, japonica, japonica, cypress, hange, chinensis, cypress, cypress, or an extract of a herbal medicine selected from the group consisting of one or more types of amphoteric surfactants and semipolar surfactants; and one or more types of nonionic surfactants having a nitrogen atom in the molecule. Hair nourishment.
クリハラン、オオギ、オウロ、カッコン、グバク、ケイ
ヒ、ゲドクシ、ゴカヒ、コソウ、ゴミシ、コブシ、コノ
テガシワ、サンキュウ、チンピ、テウチグルミ、セイコ
ウ、サンシヨウ、ドクヨウイッシカ、ショウブ、ショウ
バク、シラカバ、ニレ、リョウキョウ、リュウヨウ、ヨ
チシ、ホコツシ、トウヨウ、ヒャクゴウ、レン、モクセ
イ、ハンミョウ、フヒョウ、マクワウリ、ハクコウ、ハ
ンゲ、ハクセン、ハクショウ、ハクヨウからなる群から
選ばれる生薬の抽出物の一種又は二種以上と、アミンオ
キシドとを含有することを特徴とする養毛料。(4) Aogiri, Anmaroku, Ubai, Nettle, Ookuriharan, Oogi, Ouro, Kakkon, Gubaku, Keihi, Gedokushi, Gokahi, Kosou, Gomishi, Kobushi, Konotegashiwa, Sankyu, Chimpi, Teuchigurumi, Seikou, Sanshiyou, Dokuyouishika, Calamus, Shobu , birch, elm, chinensis, ryuyou, yochishi, hokotsushi, trumpet, hyakugo, wren, osmanthus, japonica, japonica, japonica, cypress, hange, chinensis, cypress, cypress, or an extract of a herbal medicine selected from the group consisting of A hair nourishing agent characterized by containing two or more types and an amine oxide.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63198888A JP2814085B2 (en) | 1988-08-11 | 1988-08-11 | Hair restoration |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63198888A JP2814085B2 (en) | 1988-08-11 | 1988-08-11 | Hair restoration |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH0248517A true JPH0248517A (en) | 1990-02-19 |
JP2814085B2 JP2814085B2 (en) | 1998-10-22 |
Family
ID=16398604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP63198888A Expired - Lifetime JP2814085B2 (en) | 1988-08-11 | 1988-08-11 | Hair restoration |
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JP (1) | JP2814085B2 (en) |
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KR101757775B1 (en) * | 2016-06-24 | 2017-07-17 | 연세대학교 원주산학협력단 | Composition for prevention or treatment of hair loss comprising extracts of oriental melon leaves |
KR101944259B1 (en) * | 2016-07-05 | 2019-01-30 | 농업회사법인지에프엔주식회사 | Hair restorer composition using the natural |
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JPS5484038A (en) * | 1977-12-13 | 1979-07-04 | Kunio Nagaoka | Hair tonic solution containing extracts of ginger and japanese pepper |
JPS5753401A (en) * | 1980-09-17 | 1982-03-30 | Pola Chem Ind Inc | Hair nourishing agent for promoting hair growth |
JPS60178805A (en) * | 1984-02-22 | 1985-09-12 | Yakurigaku Chuo Kenkyusho:Kk | Hair cosmetic blended with essence extracted from acanthopanax spinosus miq. |
JPS643126A (en) * | 1987-06-26 | 1989-01-06 | Bitamin Kenkyusho:Kk | Androgen acceptor bonding inhibitor |
JPS643125A (en) * | 1987-06-23 | 1989-01-06 | Ichimaru Pharcos Co Ltd | Testosterone 5alpha-reductase inhibitor |
JPH01246211A (en) * | 1987-12-10 | 1989-10-02 | Pola Chem Ind Inc | Hair-restoring or growing accelerator |
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JPS5484038A (en) * | 1977-12-13 | 1979-07-04 | Kunio Nagaoka | Hair tonic solution containing extracts of ginger and japanese pepper |
JPS5753401A (en) * | 1980-09-17 | 1982-03-30 | Pola Chem Ind Inc | Hair nourishing agent for promoting hair growth |
JPS60178805A (en) * | 1984-02-22 | 1985-09-12 | Yakurigaku Chuo Kenkyusho:Kk | Hair cosmetic blended with essence extracted from acanthopanax spinosus miq. |
JPS643125A (en) * | 1987-06-23 | 1989-01-06 | Ichimaru Pharcos Co Ltd | Testosterone 5alpha-reductase inhibitor |
JPS643126A (en) * | 1987-06-26 | 1989-01-06 | Bitamin Kenkyusho:Kk | Androgen acceptor bonding inhibitor |
JPH01246211A (en) * | 1987-12-10 | 1989-10-02 | Pola Chem Ind Inc | Hair-restoring or growing accelerator |
Cited By (20)
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FR2673840A1 (en) * | 1991-03-14 | 1992-09-18 | Lvmh Rech | COSMETIC OR PHARMACEUTICAL COMPOSITION, PARTICULARLY DERMATOLOGICAL, CONTAINING OXYACANTHIN, PARTICULARLY FOR STIMULATING THE PUSH OF HAIR OR FOR DELAYING THEIR FALL. |
US5607693A (en) * | 1991-03-14 | 1997-03-04 | Lvmh Recherche | Cosmetic or pharmaceutical composition, especially dermatological composition, containing oxyacanthine, intended in particular for stimulating hair growth or retarding hair loss |
JPH07285833A (en) * | 1994-04-15 | 1995-10-31 | Atsushi Nukada | Hair tonic agent |
WO1998052516A1 (en) * | 1997-05-19 | 1998-11-26 | Shiseido Company, Ltd. | Scalp care compositions |
JPH11240823A (en) * | 1998-02-23 | 1999-09-07 | Shiseido Co Ltd | Activator for hair papilla |
WO1999049839A1 (en) * | 1998-04-01 | 1999-10-07 | Hyo Suk Park | Topical liquid composition for promoting hair growth and process of manufacturing thereof |
JP2000143437A (en) * | 1998-11-09 | 2000-05-23 | Ichimaru Pharcos Co Ltd | Cosmetic composition containing huhectant vegetable extract |
JP2000143488A (en) * | 1998-11-16 | 2000-05-23 | Ichimaru Pharcos Co Ltd | Cosmetic composition containing humectant plant extract |
KR20010000574A (en) * | 2000-02-14 | 2001-01-05 | 조종원 | Hair tonic for hair growth and prevention of depilation |
JP2002284648A (en) * | 2001-03-27 | 2002-10-03 | National Institute Of Advanced Industrial & Technology | Composition for hair restorer |
JP2006176424A (en) * | 2004-12-21 | 2006-07-06 | Maruzen Pharmaceut Co Ltd | TESTOSTERONE 5alpha-REDUCTASE INHIBITOR AND HAIR-GROWING COSMETIC |
JP2006232828A (en) * | 2005-01-28 | 2006-09-07 | Lion Corp | Hair growing tonic, hair growing tonic composition and method of hair growth and restoration |
JP2006219407A (en) * | 2005-02-09 | 2006-08-24 | Maruzen Pharmaceut Co Ltd | Hair papilla cell proliferation promoter and hair tonic |
JP2007197387A (en) * | 2006-01-27 | 2007-08-09 | Maruzen Pharmaceut Co Ltd | TESTOSTERONE 5alpha-REDUCTASE INHIBITOR |
JP2009530369A (en) * | 2006-03-21 | 2009-08-27 | ヘオング ゲオン チョイ | Natural herbal hair growth promoting composition and method for producing the same |
DE102008035442A1 (en) | 2008-07-26 | 2010-01-28 | Ernst-Moritz-Arndt-Universität Greifswald | Preparations from Artemisia Annua, their transformation into micro- and nanoparticles and their use |
DE102008035443A1 (en) | 2008-07-26 | 2010-04-29 | Ernst-Moritz-Arndt-Universität Greifswald | Surfactant-free emulsions with anti-aging effect, their preparation and their use |
JP2011084523A (en) * | 2009-10-16 | 2011-04-28 | Nicca Chemical Co Ltd | Fibroblast growth factor-7 production promoter, and scalp/hair cosmetic, food and drink containing the same |
JP2015083571A (en) * | 2014-11-21 | 2015-04-30 | 日華化学株式会社 | Fibroblast growth factor-7 production promoter, and cosmetic for scalp and hair and food and drink containing same |
KR20220015016A (en) * | 2020-07-30 | 2022-02-08 | 지정옥 | Pharmaceutical composition for preventing or treating alopecia comprising betula platyphylla extract as an active ingredient |
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