JPS643126A - Androgen acceptor bonding inhibitor - Google Patents
Androgen acceptor bonding inhibitorInfo
- Publication number
- JPS643126A JPS643126A JP62157605A JP15760587A JPS643126A JP S643126 A JPS643126 A JP S643126A JP 62157605 A JP62157605 A JP 62157605A JP 15760587 A JP15760587 A JP 15760587A JP S643126 A JPS643126 A JP S643126A
- Authority
- JP
- Japan
- Prior art keywords
- radix
- androgen
- extract
- semen
- schtellariae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
Abstract
PURPOSE:To obtain androgen acceptor bonding inhibitor containing extract of crude drugs such as Swertiae Herba, S. Pseudochinensis Hara, Schtellariae Radix or Glycyrrhizae Radix, useful in prevention of androgen dependent disease and advantageous in acquisition of raw material and cost. CONSTITUTION:Extract of crude drug obtained from Swertiae Herba, S. Pseudochinensis Hara, Schtellariae Radix, Glycyrrhizae Radix, Rhei Rhizonma, San-chi ginseng, Phyllostachysis Folium, Citri Leiocarpae Exocarpium, Arecae Semen, Caryophylli Flos, Bupleuri Radix, Coicis Semen, Cnidii Rhizome, Chinese peony, Gambir, Polygalae Radix, Plantaginis Semen, etc. are contained as active ingredients. The extraction is carried out by immersing dried product, finely cut product or ground product of whole glass of crude drugs in a solvent such as pentane or hexane and subjecting the extract to filtration and centrifugal separation. The inhibitor is used in prevention and remedy for androgen- dependent disease, for example, hirsutism, spasm, android baldness, prostatic hypertrophy, prostatic ulcer, early maturation, etc.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62157605A JP2655646B2 (en) | 1987-06-26 | 1987-06-26 | Androgen receptor binding inhibitor |
CA000570091A CA1308661C (en) | 1987-06-26 | 1988-06-22 | AGENT FOR INHIBITING BINDING OF 5.alpha.-DIHYDRO-TESTOSTERONE WITH ANDROGEN RECEPTOR AS WELL AS PROCESS FOR OBTAINING SAME |
US07/210,489 US4987150A (en) | 1987-06-26 | 1988-06-23 | Agent for inhibiting binding of 5-dihydro-testosterone with androgen receptor as well as process for obtaining same |
EP88110140A EP0296625A3 (en) | 1987-06-26 | 1988-06-24 | Agent for inhibiting binding of 5 alpha -dihydrotestosterone with androgen receptor as well as process for obtaining same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62157605A JP2655646B2 (en) | 1987-06-26 | 1987-06-26 | Androgen receptor binding inhibitor |
Publications (3)
Publication Number | Publication Date |
---|---|
JPS643126A true JPS643126A (en) | 1989-01-06 |
JPH013126A JPH013126A (en) | 1989-01-06 |
JP2655646B2 JP2655646B2 (en) | 1997-09-24 |
Family
ID=15653378
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP62157605A Expired - Lifetime JP2655646B2 (en) | 1987-06-26 | 1987-06-26 | Androgen receptor binding inhibitor |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2655646B2 (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6438011A (en) * | 1987-07-31 | 1989-02-08 | Pola Chem Ind Inc | Promoter for hair restoration and hair growth |
JPH0236125A (en) * | 1988-07-26 | 1990-02-06 | Ichimaru Pharcos Co Ltd | Testosterone 5alpha-reductase inhibitor |
JPH0248517A (en) * | 1988-08-11 | 1990-02-19 | Shiseido Co Ltd | Hair tonic |
JPH0393710A (en) * | 1989-09-07 | 1991-04-18 | Ichimaru Pharcos Co Ltd | External preparation or cosmetic for skin or hair containing rearing inhibitor of propionibacterium acnes |
JPH07285833A (en) * | 1994-04-15 | 1995-10-31 | Atsushi Nukada | Hair tonic agent |
JP2002179584A (en) * | 2000-12-13 | 2002-06-26 | Maruzen Pharmaceut Co Ltd | TESTOSTERONE 5alpha-REDUCTASE INHIBITOR AND ANDROGEN RECEPTOR BINDING INHIBITOR, HAIR AGENT AND SKIN COSMETIC |
JP2003026592A (en) * | 2001-07-09 | 2003-01-29 | Nippon Hypox Lab Inc | Anti-androgenic agent comprising fermented licorice extract |
JP2003089626A (en) * | 2001-09-20 | 2003-03-28 | Kao Corp | Agent for inhibiting hair growth |
JP2007505151A (en) * | 2003-05-25 | 2007-03-08 | 杭州浙大力夫生物科技有限公司 | Application of bamboo leaf flavone in preventive and therapeutic drugs for prostate diseases and health foods |
JP2008502712A (en) * | 2004-06-11 | 2008-01-31 | ユニジェン インク. | Androgenic composition comprising bamboo or bamboo extract |
JP2009001523A (en) * | 2007-06-22 | 2009-01-08 | Maruzen Pharmaceut Co Ltd | Antiandrogenic agent, hair grower and hair cosmetic |
JP2009114082A (en) * | 2007-11-02 | 2009-05-28 | Maruzen Pharmaceut Co Ltd | Hair papilla cell proliferation promoter, fibroblast growth factor-7 (fgf-7) production promoter, vascular endothelial growth factor (vegf) production promoter, antiandrogenic agent, hair grower and hair cosmetic |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4730985B2 (en) * | 1997-09-10 | 2011-07-20 | 武田薬品工業株式会社 | Stabilized pharmaceutical formulation |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5970605A (en) * | 1982-10-13 | 1984-04-21 | Hiroshi Doi | Hair tonic |
JPS60146829A (en) * | 1984-01-05 | 1985-08-02 | Rooto Seiyaku Kk | Testosterone 5alpha-reductase inhibitor |
JPS6147411A (en) * | 1984-08-15 | 1986-03-07 | Dai Ichi Seiyaku Co Ltd | Promoter for hair growth |
-
1987
- 1987-06-26 JP JP62157605A patent/JP2655646B2/en not_active Expired - Lifetime
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5970605A (en) * | 1982-10-13 | 1984-04-21 | Hiroshi Doi | Hair tonic |
JPS60146829A (en) * | 1984-01-05 | 1985-08-02 | Rooto Seiyaku Kk | Testosterone 5alpha-reductase inhibitor |
JPS6147411A (en) * | 1984-08-15 | 1986-03-07 | Dai Ichi Seiyaku Co Ltd | Promoter for hair growth |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6438011A (en) * | 1987-07-31 | 1989-02-08 | Pola Chem Ind Inc | Promoter for hair restoration and hair growth |
JP2559750B2 (en) * | 1987-07-31 | 1996-12-04 | ポーラ化成工業株式会社 | Hair growth and hair growth promotion charges |
JPH0236125A (en) * | 1988-07-26 | 1990-02-06 | Ichimaru Pharcos Co Ltd | Testosterone 5alpha-reductase inhibitor |
JPH0248517A (en) * | 1988-08-11 | 1990-02-19 | Shiseido Co Ltd | Hair tonic |
JPH0393710A (en) * | 1989-09-07 | 1991-04-18 | Ichimaru Pharcos Co Ltd | External preparation or cosmetic for skin or hair containing rearing inhibitor of propionibacterium acnes |
JPH07285833A (en) * | 1994-04-15 | 1995-10-31 | Atsushi Nukada | Hair tonic agent |
JP2002179584A (en) * | 2000-12-13 | 2002-06-26 | Maruzen Pharmaceut Co Ltd | TESTOSTERONE 5alpha-REDUCTASE INHIBITOR AND ANDROGEN RECEPTOR BINDING INHIBITOR, HAIR AGENT AND SKIN COSMETIC |
JP2003026592A (en) * | 2001-07-09 | 2003-01-29 | Nippon Hypox Lab Inc | Anti-androgenic agent comprising fermented licorice extract |
JP2003089626A (en) * | 2001-09-20 | 2003-03-28 | Kao Corp | Agent for inhibiting hair growth |
JP4564694B2 (en) * | 2001-09-20 | 2010-10-20 | 花王株式会社 | Hair growth inhibitor |
JP2007505151A (en) * | 2003-05-25 | 2007-03-08 | 杭州浙大力夫生物科技有限公司 | Application of bamboo leaf flavone in preventive and therapeutic drugs for prostate diseases and health foods |
JP2008502712A (en) * | 2004-06-11 | 2008-01-31 | ユニジェン インク. | Androgenic composition comprising bamboo or bamboo extract |
JP2009001523A (en) * | 2007-06-22 | 2009-01-08 | Maruzen Pharmaceut Co Ltd | Antiandrogenic agent, hair grower and hair cosmetic |
JP2009114082A (en) * | 2007-11-02 | 2009-05-28 | Maruzen Pharmaceut Co Ltd | Hair papilla cell proliferation promoter, fibroblast growth factor-7 (fgf-7) production promoter, vascular endothelial growth factor (vegf) production promoter, antiandrogenic agent, hair grower and hair cosmetic |
Also Published As
Publication number | Publication date |
---|---|
JP2655646B2 (en) | 1997-09-24 |
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Legal Events
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EXPY | Cancellation because of completion of term | ||
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Free format text: PAYMENT UNTIL: 20080530 Year of fee payment: 11 |