JP2559750B2 - Hair growth and hair growth promotion charges - Google Patents

Description

TECHNICAL FIELD The present invention relates to a novel hair growth / hair growth promoting agent.

(Problems to be Solved by Prior Art and Invention) Conventionally, various compounds, extracts such as herbal medicines, etc. have been applied to hair growth / hair growth promoters, but there are almost no remarkable effects. In addition, those having a certain degree of effect have a drawback that they are so irritating that they cause dermatitis and that continuous use is difficult.

(Means for Solving Problems) Therefore, the present inventors have conducted various experimental studies in view of the present situation, and as a result, by containing a crude drug extract extracted from the crude drug of Fuyu melon or bamboo leaf, The inventors have found that they can be solved and completed the present invention.

That is, the present invention is directed to Benincasa hispida Cog
n. Seeds] or bamboo leaves [Lophatherum gracile Brongn leaves] with at least one crude drug extract extracted with a water-soluble organic solvent or a water-containing water-soluble organic solvent. It is about.

 Hereinafter, the present invention will be described in detail.

As a method for obtaining a hair growth / hair growth promoting agent applied to the present invention, 100 g of winter melon or bamboo leaf crude drug, for example, a primary alcohol such as methanol, ethanol, propanol, butanol, or an organic solvent of acetone, tetrahydrofuran or dioxane is used. Distillation extraction is carried out three times for 2 hours each alone or with a water-containing organic solvent 11 containing 50% by weight or more of the above primary alcohol or acetone, tetrahydrofuran and dioxane. These extracts are combined, suction filtered, and concentrated to dryness under reduced pressure to remove the solvent to obtain a viscous crude drug extract. The obtained crude drug extract is blended in the base as it is or by dissolving, dispersing and diluting it with an appropriate solvent or the like to obtain the hair growth / hair growth promoting agent of the present invention.

Here, the content of one or more of winter melon seed and bamboo leaf crude drug extract contained as an active ingredient of the hair growth and hair growth-promoting agent according to the present invention is 0.1 to 10% by weight, preferably 0.5 to 5% by weight. .

The hair growth and hair growth-promoting agent containing at least one crude herbal extract from winter melon and bamboo leaf applied to the present invention is shown in the table below.
In the method for measuring the density of mouse hair growth shown in 1, that is, in Test Method I, a remarkable effect was shown as compared with other substances called hair growth / hair growth promoting agents. This is a result of the components of the crude drug extract extracted from the crude drug stimulating the hair root, making blood circulation around the hair root more active, and improving metabolism.

Brief Description of Test Method I Using 9-week-old C3H mice, one group has 10 mice,
Make 4 groups and apply 0.02g of the sample on the next day after removing hair to the area where the hair was removed to an area of 2.0 cm × 2.0 cm on the 9th day, 1
On the 1st and 14th days, the density of hair growth at the site was grasped as a degree of increase in blackness by using a color difference meter, and compared with conventional vitamin E as a comparative substance and 99.5% ethanol solution as a control.

In each sample applied in Table-1, A is a 99.5% ethanol solution containing 2% by weight of vitamin E as a comparative substance, and B and C are herbal extracts obtained by extraction of winter melon and bamboo leaf with methanol, respectively. 5% by weight of 99.5%
An ethanol solution, D is a 99.5% ethanol solution as a control.

 Next, examples of clinical trials will be shown.

Production example 1. Winter melon kernel extract crude drug extract 100 g of winter melon kernel purchased from Osaka crude drug market was weighed and chopped into pieces of about 5 mm width, and then digested with 11 70V / V% methanol for 2 hours and then extracted. The liquid was filtered. The extraction filtrates obtained by repeating this extraction operation three times were combined and
The solvent was distilled off at 60 ° C. to obtain 13.5 g of a viscous dark brown crude drug extract having a characteristic odor.

Production Example 2. Bamboo Leaf Extract Crude Drug Extract 100 g of bamboo leaves purchased from Osaka Crude Drug Market were weighed, shredded to a width of about 5 mm, and then digested with 11 methanol for 2 hours, and then the extract was filtered. . The extraction filtrates obtained by repeating this extraction operation three times were combined, and the solvent was distilled off at 40 ° C. under reduced pressure to obtain 12.5 g of a viscous dark brown crude drug extract having a characteristic odor.

Example 1 As a sample, a 99.5% ethanol solution containing 2% by weight of the Chinese cabbage extract extracted from winter melon was used.

A sample of alopecia areata, a 44-year-old female with a 3 cm diameter bald area on the occipital region, was applied once a day with 3-5 g of the sample once a day, and short hairs were produced at the bald area after about 3 months. , 6 months later, the hair became bristles and the hair loss site disappeared.

Example 2 2% by weight of the bamboo leaf extract crude drug extract of Production Example 2 as a sample
The contained 99.5% ethanol solution was used.

One sample per day for alopecia areata male, 36 years old, having hair loss parts 2.5 cm in diameter on the parietal region and the temporal region.
When 3 to 5 g was applied once per time, short vellus hair was produced at the hair loss site of the crown and temporal region after 3 months, and vellus hair was produced after 6 months, but it was not completely cured.

In both Examples 1 and 2, no skin damage was observed due to continuous application for 6 months.

Next, examples of the present invention will be described. The mixing ratio is parts by weight.

Example 1 Hair Tonic Winter Gourd Extract Extract Crude Drug Extract (Production Example 1) 2.0 Menthol 0.2 99.5% Ethanol 60.0 Purified Water 37.8 (Manufacturing Method) The Winter Gourd Extract Herb Extract Extract and Menthol were dissolved in 99.5% ethanol, and then purified water was added. Got a hair tonic.

Example 2 Hair Cream Bamboo Leaf Extract Crude Drug Extract (Production Example 2) 1.0 Vaseline 7.0 Beeswax 8.0 Cristol 37.0 Emulsifier 5.5 Purified Water 41.5 (Production Method) Bamboo Leaves Extract Crude Drug Extract, Vaseline, Beeswax, Cristol and Emulsifier were mixed. Dissolved at 80 ° C., and then purified water at 80 ° C. was gradually added to the oil phase and then cooled to obtain a hair cream.

Example 3 Ointment Winter gourd extract crude drug extract (Production Example 1) 0.5 Bamboo leaf extract crude drug extract (Production Example 2) 1.0 Isopropyl myristate 10.0 Cetanol 2.0 Paraffin wax 6.0 Microcrystalline wax 10.0 Emulsifier 11.0 Purified water 59.5 (Production method) Bamboo leaf extract Crude drug extract, isopropyl myristate, cetanol, paraffin wax, microcrystalline wax, and emulsifier are heated and melted. Separately, purified water heated to 70 ° C or higher is added and stirred, and then cooled to 40 ° C to obtain an ointment. It was

Claims (1)

(57) [Claims] 1. A hair-growth / hair-growth promoting agent, which comprises at least one crude drug extract obtained by extracting a crude drug of winter melon or bamboo leaf with a water-soluble organic solvent or a water-containing water-soluble organic solvent.