JP2544149B2 - Hair growth and hair growth promotion charges - Google Patents

Description

TECHNICAL FIELD The present invention relates to a novel hair growth / hair growth promoting agent.

(Problems to be Solved by Prior Art and Invention) Conventionally, various compounds, extracts such as herbal medicines, etc. have been applied to hair growth / hair growth promoters, but there are almost no remarkable effects. In addition, those having a certain degree of effect have a drawback that they are so irritating that they cause dermatitis and that continuous use is difficult.

(Means for Solving Problems) As a result of various experimental studies in view of such a current situation, the present inventors have achieved the above-mentioned conditions to be solved by containing a crude drug extract extracted from a crude drug of sweet pine or apricot kernel or agarwood. They have found that they are satisfied and have completed the present invention.

That is, the present invention relates to a hair-growth and hair-growth promoting agent containing at least one crude drug extract obtained by extracting a crude drug of sweet pine or apricot kernel or agarwood with a water-soluble organic solvent or a water-containing water-soluble organic solvent. .

 The present invention will be described in detail below.

As a method for obtaining a hair growth / hair growth promoting agent applied to the present invention, 100 g of apricot or apricot kernel or agarwood crude drug, for example, a primary alcohol such as methanol, ethanol, propanol, butanol, or an organic solvent such as acetone, tetrahydrofuran or dioxane is used. Solvent alone or water-containing organic solvent 11 containing 50% by weight or more of the above primary alcohol or acetone, tetrahydrofuran or dioxane for 2 hours 3
Extract by digestion. These extracts are combined, filtered with suction, and concentrated to dryness under reduced pressure to remove the solvent to obtain a viscous crude drug extract. The obtained herbal medicine extract is dissolved or dispersed and diluted with an appropriate solvent or the like into a base to obtain the hair growth and hair growth-promoting agent of the present invention.

Here, the content of one or more of the sweet pine, apricot kernel, and agarwood herb extracts contained as an active ingredient of the hair growth and hair growth-promoting agent according to the present invention is 0.1 to 10.0% by weight, preferably 0.5 to 5.0% by weight. .

The hair growth and hair growth-promoting agent containing one or more of the extract of herbal medicines extracted from sweet pine, apricot kernel and agarwood applied to the present invention is a method for measuring the density of hair growth of mice shown in Table 1 below, that is, a test In Method I, a remarkable effect was shown as compared with other substances called hair growth and hair growth promoters. This is a result of the fact that the components of the crude drug extract extracted from the above crude drugs stimulated the hair roots, increased blood circulation around the hair roots, and improved metabolism.

Brief Description of Test Method I Using 9-week-old C3H mice, one group has 10 mice,
Make 4 groups and apply 0.02g of the sample on the next day after removing hair to the area where the hair was removed to an area of 2.0 cm × 2.0 cm on the 9th day, 1
On the 1st and 14th days, the density of hair growth at the site was grasped as a degree of increase in blackness by using a color difference meter, and compared with conventional vitamin E as a comparative substance and 99.5% ethanol solution as a control.

In each sample applied in Table-1, A is a 99.5% ethanol solution containing 2% by weight of vitamin E as a comparative substance, and B, C and D are obtained by extraction of sweet pine, apricot kernels and agarwood with methanol, respectively. 99.5% ethanol solution containing 5% by weight of crude drug extract, E as a control
It is 99.5% ethanol.

Production Example 1. Sweet pine extract crude drug extract 100 g sweet pine purchased from the Osaka crude drug market was weighed and made into a coarse powder of about 20 mesh with a crusher, and 1 l of 70
Digestion was performed with wt% methanol for 2 hours, and then the extract was filtered. The extraction filtrates obtained by repeating this extraction operation three times were combined, and the solvent was distilled off at 60 ° C. under reduced pressure to obtain 13.8 g of a viscous dark brown crude drug extract having a characteristic odor.

Production Example 2. Agarwood Extract Crude Drug Extract 100 g of agarwood purchased from Osaka crude drug market was weighed and made into a coarse powder of about 20 mesh with a crusher, and 1 l of 50
Digestion with wt% ethanol was performed for 2 hours, and then the extract was filtered. The extraction filtrates obtained by repeating this extraction operation three times were combined and the solvent was distilled off at 60 ° C. under reduced pressure to obtain 14.1 g of a viscous dark brown crude drug extract having a peculiar odor.

Production Example 3. Apricot kernel extract crude drug extract 100 g of apricot kernel purchased from the Osaka crude drug market was weighed and made into a coarse powder of about 20 mesh with a crusher, and then digested with 1 l of methanol for 2 hours, and then the extract Was filtered. The extraction filtrates obtained by repeating this extraction operation three times were combined and the solvent was distilled off under reduced pressure at 60 ° C. to obtain 11.7 g of a viscous dark brown crude drug extract having a characteristic odor.

 Next, examples of clinical trials will be shown.

Example 1 2% by weight of the sweet pine extract crude drug extract of Production Example 1 as a sample
The contained 99.5% ethanol solution was used.

A sample of alopecia areata, a 44-year-old female with a 3 cm diameter bald area on the occipital region, was applied once a day with 3 to 5 g of the sample, and short vellus hair was produced at the bald area after about 3 months. After 6 months, the hair became bristles and the hair loss site disappeared.

Example 2 As a sample, the herbal extract of agarwood extract of Production Example 2 and Production Example 3
2 a mixture of apricot kernel extract crude drug extract in a ratio of 1: 1
A 99.5% ethanol solution containing wt% was used.

One sample per day for alopecia areata male, 36 years old, having hair loss parts 2.5 cm in diameter on the parietal region and the temporal region.
When 3 to 5 g was applied once per time, vellus hair was produced at the hair loss site of the crown and temporal region after 3 months, and vellus hair was produced after 6 months, but it was not completely cured.

In both Examples 1 and 2, no skin damage due to continuous application for 6 months was observed.

 Next, prescription examples are shown. The mixing ratio is parts by weight.

Example 1 Hair Tonic Sweet pine extract crude drug extract (Production Example 1) 2.0 Menthol 0.2 99.5% ethanol 60.0 Purified water 37.8 Manufacturing method 99.5% ethanol was prepared by dissolving the sweet pine extract crude drug extract and menthol and then adding purified water. .

Example 2 Hair Cream Apricot kernel extract crude drug extract (Production Example 3) 1.0 Vaseline 7.0 Beeswax 8.0 Cristol 37.0 Emulsifier 5.5 Purified water 41.5 Manufacturing method Apricot kernel extract crude drug extract, vaseline, beeswax, cristol and emulsifier were mixed at 80 ° C. After dissolution, purified water at 80 ° C was gradually added to the oil phase to form a cream.

Example 3 Ointment Sweet pine extract crude drug extract (Production example 1) 0.5 Apricot kernel extract crude drug extract (Production example 3) 1.0 Agarwood extract crude drug extract (Production example 2) 0.5 Isopropyl myristate 10.0 Cetanol 2.0 Paraffin wax 6.0 Microcrystalline wax 10.0 Emulsifier 11.0 Purified water 59.0 Manufacturing method Sweet pine, apricot kernel and agarwood extract crude drug extract, isopropyl myristate, cetanol, paraffin wax, microcrystalline wax, and emulsifier are heated and melted, and purified water heated to 70 ° C or more is added and stirred to 40 ° C. It was cooled with stirring.

Claims (1)

(57) [Claims] 1. A hair-growth and hair-growth promoter comprising at least one crude drug extract obtained by extracting a crude drug of sweet pine, apricot kernel, or agarwood with a water-soluble organic solvent or a water-containing water-soluble organic solvent.