JP2542849B2 - Topical skin - Google Patents

Description

TECHNICAL FIELD The present invention relates to a novel external preparation for skin, more specifically, it prevents or alleviates skin inflammation, which is characterized by containing an extract of Ibuquitranoo. It relates to a skin external preparation.

The object of the present invention is to provide a skin external preparation which is excellent in the effect of preventing skin roughness and the effect of improving skin roughness, which prevents and relieves inflammation of the skin due to sunburn, rough skin, trauma, acne and the like.

[Prior Art] Conventionally, as a plant extract having an anti-inflammatory effect, licorice,
Various materials such as yellow oak and purple root are known, and attempts have been made to blend them into an external preparation for skin in the hope of preventing rough skin and improving rough skin.

[Problems to be Solved by the Invention] However, in the plant extracts that have been conventionally used,
Those having an effective effect of improving rough skin have been limited.

[Means for Solving the Problems] In view of the above points, the present inventors have conducted diligent research on various plant extracts, and as a result, the Ibuquitranoo extract has an excellent anti-inflammatory action and contains it. It was found that even in the external preparation for skin, a remarkable effect of preventing rough skin can be obtained,
The present invention has been completed.

That is, the present invention provides an external preparation for skin which is characterized by containing an extract of Ibuquitranoo and which is excellent in the effect of preventing rough skin and the effect of improving rough skin, and which prevents or reduces inflammation of the skin.

Examples of the Ibuquitranoo extract that is essential in the present invention include Ibuquitranoo (Polygonum bistorta).
L.) rhizome / whole grass, and those obtained by extracting from generally known Ginseng and the like can be preferably used in the present invention. In addition to these, it is also possible to use Mucogotranoo (Polygonum viviparum L.) and Harutoranoo (P.tenuicaule BISS.et MOORE), which are plants belonging to the same genus Ibukitoranoo. The extraction method is not particularly limited, for example, as the extraction solvent, water, a lower monohydric alcohol such as methyl alcohol and ethyl alcohol, a liquid polyhydric alcohol such as propylene glycol and 1,3-butylene glycol, a lower alkyl such as ethyl acetate. Examples thereof include esters, hydrocarbons such as benzene and hexane, ethyl ether, and the like, and these may be used alone or in combination of two or more. An extract obtained by filtering with these extraction solvents at room temperature or by heating, or a concentrate thereof is used.

The content of Ibuquitrano extract in the external preparation for skin is ineffective if it is too small, and the solid content is 0.001.
The range of -10.0% by weight is sufficient for the purpose of the present invention, and it is preferable that it is in the range of 0.01-20.0% by weight as an extract from the viewpoint of product formulation, especially 0.01-5 as a solid content.
More preferably, it is in the range of 0% by weight and the extract as 0.1 to 10.0% by weight.

In the present invention, as a skin external base material containing the above-mentioned Ibuquitranoo extract, an aqueous component, a powder, a surfactant, an oil component, a moisturizer, an alcohol, a pH adjusting agent which is usually used in cosmetics / quasi drugs / pharmaceuticals. , Preservatives, antioxidants,
Any thickener, pigment, fragrance, and the like may be appropriately mixed and prepared.

The dosage form of the external preparation for skin referred to in the present invention is not particularly limited, and may be a dosage form such as a lotion, an emulsion, a cream, a pack, an ointment, a dispersion and the like.

In addition, the external preparation for skin of the present invention includes, in addition to the extract of Ibuquitranoo, known drugs, for example, glycyrrhetinic acid and its derivatives, anti-inflammatory agents such as indomethacin, ascorbic acid, glutathione and their derivatives, placenta extract, and the like. It is also possible to mix and combine agents having a whitening effect, such as natural extract and mulberry bark extract, and ultraviolet absorbers, and they may be used in combination with products in the hope of synergistic effect.

Next, the following test was carried out in order to show the anti-inflammatory effect of the Ibuquitranoo extract according to the present invention.

(Inflammation suppression test) According to the carrageenin footpad edema method, 10 Wistar male rats aged 5 weeks were used as a group, and 1% carrageenin physiological saline solution was used as a provocative substance by subcutaneous injection into the rat hindlimb footpad. Caused.

Two hours before, one hour before and immediately after the injection of carrageenin, the sample application group was prepared by applying 0.1 ml each of the methyl alcohol extract of Rhizophora rhizome finally dissolved in olive oil at a ratio of 5% as a solid content. The control group was applied only with olive oil. Table 1 shows the volume of edema and the rate of inhibition of edema formation 3 hours after the injection of carrageenin. The values in the table are average values in each group.

As is clear from the results in Table 1, it was confirmed that the Ibucchitrano extract according to the present invention suppressed the inflammation caused by carrageenin.

[Examples] Next, the present invention will be further described with reference to examples. These do not limit the invention in any way.

Example [I] Cream (formulation) (% by weight) (1) Ibuquitranoo whole plant ether extract (as solid content) 3.0 (2) Stearic acid 1.0 (3) Stearyl alcohol 4.0 (4) Glycerin monostearate 3.0 ( 5) Hardened oil 7.0 (6) Liquid paraffin 10.0 (7) Safflower oil 2.0 (8) Sorbitan sesquioleate 1.0 (9) Perfume 0.1 (10) Carboxyvinyl polymer 0.1 (11) Sodium hydroxide 0.05 (12) Preservative 0.1 (13) Remaining amount of purified water (Production method) A (1) to (9) are heated and dissolved.

B. Dissolve (10) to (13) by heating.

B is added to C A to emulsify and cool to obtain a cream.

Example [2] Ointment (formulation) (% by weight) (1) 50% ibukitranano rhizome 1,3-butylene glycol extract 1.0 (2) carboxyvinyl polymer 1.0 (3) hydroxyethyl cellulose 1.0 (4) polyethylene glycol 10.0 ( 5) Ethyl alcohol 30.0 (6) Diisopropyl adipate 2.0 (7) Diisopropanolamine 1.1 (8) Residual amount of purified water (Production method) A (8) is partially swollen with (2) and (3).

B Add (1), (4) to (6) to A and stir.

C) (7) is dissolved in a part of (8) and added to B.

The remaining amount of water is added to DC and the mixture is stirred uniformly to obtain an ointment.

Comparative Example [1] Ointment An ointment is prepared by excluding (1) in the formulation of Example [2].

Example [2] and Comparative Example [2] obtained as described above
In the same manner, the above-mentioned carrageenin footpad edema method was used for the inflammation suppression test using the ointment of No. The sample is 0.
1g was applied 3 times. The results are shown in Table 2.

As is clear from the results in Table 2, the ointment of Example [2] had an effect of suppressing skin inflammation. In addition, when actually used, the ointment of Example [2] had an excellent effect of improving rough skin.

Example [3] Lotion (prescription) (% by weight) (1) Ginseng 50% ethyl alcohol extract 0.5 (2) Ethyl alcohol 7.0 (3) 1,3-butylene glycol 7.0 (4) Tocopherol acetate 0.05 (5) ) Preservative 0.1 (6) Perfume 0.05 (7) Polyoxyethylene sorbitan monooleate (20E.O.) 1.0 (8) Sodium lactate 0.2 (9) Horse chestnut extract 0.5 (10) Residual amount of purified water (production method) A ( 1) to (7) are mixed and dissolved.

B: Mix and dissolve (8) to (10).

A is added to CB and mixed to obtain a lotion.

[Effects of the Invention] As described in detail above, the present invention provides a novel external preparation for skin, which contains the ibukitrano extract as an essential component so that its action effects are sufficiently exerted and skin inflammation is prevented and alleviated. To do.

That is, according to the present invention, it is possible to provide a skin external preparation having an excellent anti-roughness effect, which works effectively against inflammation of the skin caused by sunburn, rough skin, trauma, acne and the like due to its anti-inflammatory effect.

Claims (1)

(57) [Claims] 1. A skin external preparation for preventing and relieving skin inflammation, which comprises an extract of Ibuquitranoo.