JPH05229931A - Skin-whitening cosmetic - Google Patents

Abstract

PURPOSE:To provide a skin-whitening cosmetic wherein the action of L-ascorbic acid to suppress the melanin formation is increased synergetically, thus showing excellent skin-whitening effect and further prophylactic and curing effects for blots and freckles caused by sun burning. CONSTITUTION:(A) At least one compound selected from L-ascorbic acid and water-soluble L-ascorbic acid derivatives (for example, a monovalent to trivalent metal salt of L-ascorbic acid ester with phosphoric acid or sulfuric acid and (B) Puerariae Radix extract, for example, the extract of the roots with a solvent such as water, ethanol, methanol, 1,3-butylene glycol and/or propylene glycol, or the powder prepared by drying the extract or isoflavon derivatives isolated from the extract are combined in such amounts as A=0.001 to 30wt.%, preferably 0.1 to 5wt.%, B=0.001 to 10wt.%, preferably 0.01 to 5wt.% to give the objective skin-whitening cosmetic having the above-stated effects.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a whitening cosmetic composition, and more particularly to a whitening cosmetic composition having an excellent skin whitening effect and capable of preventing and treating spots and freckles caused by sunburn.

[0002]

2. Description of the Related Art Skin spots and freckles are generally caused by activation of melanocytes due to stimulation due to exposure to ultraviolet rays from sunlight, hormonal abnormalities, genetic factors, etc., and the melanin pigment synthesized there is present in the skin. It is thought to occur due to abnormal deposition.

Conventionally, in order to prevent such skin spots and freckles, L-ascorbic acid and its derivatives,
Hydroquinone, arbutin, kojic acid, cysteine,
BACKGROUND ART Whitening cosmetics containing a melanin inhibitor such as glutathione or a placenta extract that exerts a whitening effect by acting on keratinocytes are used. However, these substances have problems in terms of stability, safety, odor, etc., and also have a weak whitening effect, and a sufficiently satisfactory whitening cosmetic has not been obtained yet.

[0004]

Therefore, there has been a demand for the development of a whitening cosmetic which has an excellent whitening effect on the skin, can treat spots and freckles, and can prevent the occurrence thereof.

[0005]

In view of the above circumstances, the inventors of the present invention have conducted extensive studies and as a result, one or more selected from the group consisting of L-ascorbic acid and water-soluble derivatives of L-ascorbic acid. The present invention has been completed by finding that, when used together with Kakkon extract, the whitening effect is synergistically enhanced and the above-mentioned problems can be solved.

Therefore, the present invention provides one or more of the following components (A) and (B) (A) L-ascorbic acid and a water-soluble derivative of L-ascorbic acid. The present invention provides a whitening cosmetic containing the product.

In the component (A) used in the present invention, the water-soluble derivative of L-ascorbic acid is not particularly limited as long as it is water-soluble. For example, a monovalent metal salt of L-ascorbic acid phosphoric acid ester. L-ascorbic acid phosphoric acid sodium salt, L-ascorbic acid phosphoric acid potassium salt, divalent metal salt L-ascorbic acid phosphoric acid magnesium salt, L-ascorbic acid phosphoric acid calcium salt, trivalent L which is a metal salt
-Ascorbic acid phosphoric acid aluminum salt, and L which is a monovalent metal salt of L-ascorbic acid sulfuric acid ester
-Ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, divalent metal salt L-ascorbic acid sulfate magnesium salt, L-
Ascorbic acid sulfate calcium salt, trivalent metal salt L-ascorbic acid sulfate aluminum salt, and L-ascorbic acid monovalent metal salt L-
Ascorbic acid sodium salt, L-ascorbic acid potassium salt, divalent metal salt L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, trivalent metal salt L-ascorbic acid aluminum salt and the like are preferable. Can be mentioned.

In the present invention, the component (A) may be used either alone or in combination of two or more, and may be used in an amount of 0.001 to 30% by weight, particularly 0.1% by weight based on the total amount of the cosmetic.
It is preferably blended in an amount of 1 to 5% by weight.

Further, as the Kuzukon extract of the component (B) used in the present invention, there is Kuzukon (PUERARIAE RAD).
IX) is extracted with a solvent such as water, ethanol, methanol, 1,3-butylene glycol, propylene glycol or a mixed solvent thereof, a dry powder obtained by drying the extract, or the extraction. It is possible to use one kind or a combination of two or more kinds of each component such as an isoflavone derivative separated from the liquid.

Here, as a particularly preferable method for extracting the kudzu root, for example, the method shown in the following production method 1 or production method 2 can be mentioned. (Manufacturing method: 1) For 1 kg of chopped dried kudzu root,
Add 5 times the amount of ethanol or methanol, 90 ℃, 6
Reflux extraction for a period of time, filtration is performed, the filtrate is concentrated under reduced pressure,
Drying can be performed to obtain a powder (extract defined in the present invention). The yield is 5 when the extraction solvent is ethanol.
7-63g, when using methanol 90-110g
The degree is obtained. (Manufacturing method: 2) For 1 kg of chopped dried roots,
Add 5 times the amount of ethanol or methanol, stir occasionally, store at room temperature for about 3 days, then filter, concentrate the filtrate under reduced pressure and dry to powder (extract specified in the present invention)
To get The yield is 30 to 30 when ethanol is used.
50g, 90-100g when using methanol
The degree is obtained. The extract obtained by the above-mentioned production method (extraction) is characterized by having a high content of saccharides and puerarin, and when the saccharides are converted into sucrose, the lower limit is 20%.
%, And the upper limit is about 45%. Further, as puerarin, those having a range of 20 to 40% can be obtained.

In the present invention, the component (B) is 0.001 to 10% by weight, especially 0.01% by weight in terms of dry matter in the total amount of the cosmetic.
It is preferably blended in an amount of up to 5% by weight.

Further, the whitening cosmetic composition of the present invention appropriately contains various optional components used in ordinary cosmetics, quasi-drugs, pharmaceuticals and the like other than the above-mentioned essential components as long as the effects of the present invention are not impaired. be able to. Such optional components include, for example, purified water, ethanol, oily substances, moisturizers, thickeners, preservatives, emulsifiers, medicinal components, powders, ultraviolet absorbers, pigments, fragrances, emulsion stabilizers, pH adjusters, etc. Can be mentioned. Specifically, examples of the oil component include liquid paraffin, petrolatum, paraffin wax, squalane, beeswax, carnauba wax, olive oil, lanolin, higher alcohols, fatty acids, synthetic ester oils of higher alcohols and fatty acids, silicone oils, etc., and moisturizers. Examples thereof include sorbitol, xylitol, glycerin, maltitol, propylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, sodium pyrrolidonecarboxylate, lactic acid, sodium lactate, polyoxypropylene fatty acid ester, polyethylene glycol and the like. As a thickener, carboxyvinyl polymer, carboxymethyl cellulose, polyvinyl alcohol, carrageenan, water-soluble polymers such as gelatin, electrolytes such as sodium chloride, potassium chloride, etc. Preservatives include urea, methylparaben, ethylparaben, propylparaben, butylparaben, sodium benzoate, and the like, and emulsifiers include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester. , Glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, nonionic surfactants such as polyoxyethylene sorbitol fatty acid ester, talc as powder, sericite, Mica, kaolin, silica, bentonite, vermiculite, zinc white, mica, mica titanium, titanium oxide, magnesium oxide, zirconium oxide, barium sulfate, red iron oxide, iron oxide, Blue, and the like. The whitening cosmetic composition of the present invention is preferably acidic to neutral (pH 7 or less) for the sake of system stability. Examples of the pH adjuster used here include buffers such as lactic acid-sodium lactate and citric acid-sodium citrate.

The whitening cosmetic composition of the present invention can be produced by a conventional method. Further, the whitening cosmetic subject to the present invention is not limited to general skin cosmetics, but includes quasi drugs, external medicines, etc., and its dosage form also depends on its purpose. It can be arbitrarily selected and can be in the form of cream, ointment, emulsion, lotion, solution, gel, pack, stick or the like.

[0014]

EFFECTS OF THE INVENTION The whitening cosmetic composition of the present invention provides a synergistic melanin production inhibitory effect by the combined use of the L-ascorbic acid and / or the water-soluble derivative of L-ascorbic acid and the Kakkon extract. It has an extremely excellent whitening effect on the skin and a preventive and therapeutic effect on spots and freckles caused by sunburn and the like.

[0015]

The present invention will be further described with reference to the following examples.
The present invention is not limited to these.

The evaluation of the whitening effect in this embodiment is as follows.
The whitening effect test was performed on the UV-B-induced pigment spots shown below. (Whitening Effect Test for UV-B Induced Pigment Spots) The upper arm inner part of 20 test subjects was irradiated with UV rays in the UV-B region at a dose twice as much as the minimum erythema dose once a day for 2 days for induction. The whitening effect of continuous application of the sample to the pigment spots twice a day for one month was examined. The evaluation was performed using a color difference meter (CMS-1200, manufactured by Murakami Color Co., Ltd.), and the L * value was calculated from the obtained Munsell value, and the ΔΔL * value representing the recovery was used. The ΔΔL * value was defined as follows. The L * values of the sample-applied test site and the sample-unapplied test site immediately before the start of sample application are L ₀ , L ₀ ′, and
The L * value of each site after 1 month of continuous application is L ₁ , respectively,
ΔΔL * as L ₁ ′ is expressed by the following equation. ΔΔL * = (L ₁ −L ₀ ) − (L ₁ ′ −L ₀ ′) Further, the evaluation is shown by the average value of the evaluation points of 20 test subjects.

[0017]

[Table 1]

In the following examples, the compounding amount when a liquid herbal medicine extract was used was shown by weight% as a liquid. Example 1 A cream having the composition shown in Table 2 was prepared according to the following production method, and the whitening effect by continuous application was evaluated. The results are shown in Table 2.

(Production method) The oil layer component [(1) to (6)] is added to 8
The water layer components [(7) to (15)] heated to 80 ° C. with stirring are added to the solution dissolved by heating at 0 ° C. and emulsified, and then (16) is added, and then cooled to room temperature with stirring.

[0020]

[Table 2]

From the results shown in Table 2, it can be seen that the cream of the present invention has an excellent whitening effect.

[0022]

Table 2 Example 2 Cream (composition) (% by weight) (1) Decaglyceryl stearate 1.8 (2) Polyoxyethylene cetyl ether 1.2 (3) Squalane 12.0 (4) Cetanol 6.0 (5) Cetyl palmitate 3.0 (6) 1,3-butylene glycol 6.0 (7) Glycerin 3.0 (8) Tetrasodium edetate 0.1 (9) L-ascorbic acid phosphate ester magnesium salt 3.0 (10) Kudzu root extract ^{* 2} 0.3 (11) Citric acid / sodium citrate (25:75) 1.0 (amount to adjust system pH to 5.8) (12) Purified water residue Quantity (13) Preservative Suitable quantity (14) Perfume Suitable quantity pH: 5.8

* 2: Capcon extract powder manufactured by Ichimaru Falcos Co., Ltd. (manufacturing method) An oil layer component [(1) to (5)] heated and dissolved at 80 ° C., and an aqueous layer heated to 80 ° C. with stirring. After the components [(6) to (13)] are added and emulsified, (14) is added and then cooled to room temperature with stirring.

[0024]

Table 3 Example 3 Emulsion (Composition) (wt%) (1) Polyoxytristearate ethylene sorbitan 1.0 (2) Glycerol oleate 1.0 (3) Glyceryl monostearate 0.5 (4) Squalane 6.0 (5) Glyceryl trioctanoate 2.0 (6) Cetyl octanoate 2.0 (7) Stearyl alcohol 2.0 (8) 1,3-Butylene glycol 5.0 (9) Glycerin 3.0 (10 ) Xanthan gum 0.2 (11) Tetrasodium edetate 0.1 (12) L-ascorbic acid phosphoric acid ester magnesium salt 3.0 (13) Kakkon extract ^{* 3} 1.0 (14) Aloe extract ^{* 40} .5 (15) Citric acid / sodium citrate (10:90) 1.0 (amount to adjust the pH of the system to 6.2) (16) Purified water remaining amount (17) Perfume proper amount ( 8) Preservative qs pH: 6.2

* 3: Capsule extract powder manufactured by Ichimaru Falcos Co., Ltd. * 4: Aloe MS (manufactured by Ichimaru Falcos Co., Ltd.) (preparation) Oil layer components [(1) to (7)] heated and dissolved at 80 ° C. After adding the components of the aqueous layer [(8) to (16), (18)] heated to 80 ° C. with stirring to emulsify,
Add (17) then cool to room temperature with stirring.

[0026]

Table 4 Example 4 Essence (Beauty liquid) (Composition) (wt%) (1) 1,3-butylene glycol 8.0 (2) Glycerin 4.0 (3) Xanthan gum 0.3 (4) Chondroitin sulfate Sodium 0.1 (5) Sodium hyaluronate 0.05 (6) Ethanol 3.0 (7) Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.3 (8) L-ascorbic acid phosphoric acid ester magnesium salt 3. 0 (9) Kudzu root extract ^{* 5} 0.1 (10) Mulberry bark extract ^{* 6} 1.0 (11) Citric acid / sodium citrate (15:85) 1.0 (pH of the system was 6.0) (12) Tetrasodium edetate 0.1 (13) Purified water residual amount (14) Preservative appropriate amount (15) Perfume appropriate amount pH: 6.0

* 5: Ichimaru Falcos Co., Ltd., Kacon extract powder * 6: Ichimaru Falcos Co., Ltd., Falco Rex Sakuhaku (solid content: 0.3 to 0.8% by weight) (Production method) (1) to After stirring and dispersing the component (5), 65 parts of purified water is added to the mixture to give A. On the other hand, (6),
After stirring and dissolving the components (7), (14), and (15),
The remaining amount of purified water is added to this and designated as B. While stirring A, B is added and homogenized, and then the components (8) to (12) are added and dissolved by stirring.

[0028]

Table 6 Example 5 Lotion (composition) (% by weight) (1) 1,3-butylene glycol 8.0 (2) glycerin 4.0 (3) sodium hyaluronate 0.1 (4) ethanol 3.0 (5) Polyoxyethylene polyoxypropylene decene tetradecyl ether 0.3 (6) L-ascorbic acid phosphoric acid ester magnesium salt 3.0 (7) Kakkon extract ^{* 7} 0.2 (8) Clove extract ^{* 8} 1.5 (9) Citric acid / sodium citrate (20:80) 1.0 (amount to adjust the pH of the system to 5.9) (10) Tetrasodium edetate 0.1 (11) Purified water residue Quantity (12) Preservative Suitable quantity (13) Perfume Suitable quantity pH: 5.9

* 7: Capsule extract powder manufactured by Ichimaru Falcos Co., Ltd. * 8: Falco Rex Clove (solid content: 2.0 to 4.0% by weight) manufactured by Ichimaru Falcos Co., Ltd. (manufacturing method) (1) to After stirring and dispersing the component (3), 60 parts of purified water is added to the mixture to give A. On the other hand, (4),
After stirring and dissolving the components (5), (12), and (13),
The remaining amount of purified water is added to this and designated as B. While A is stirred, B is added and homogenized, and then the components (6) to (11) are added and dissolved by stirring.

[0030]

[Table 7] Example 6 Powder (composition) (% by weight) (1) L-ascorbic acid phosphoric acid ester magnesium salt 30.0 (2) Kakkon extract ^{* 9} 5.0 (3) Scutellaria extract ^{* 10} 1 0.0 (4) Cetyl palmitate 10.0 (5) Hydrogenated soybean phospholipid 5.0 (6) D-mannitol 50.0 * 9: Ichimaru Falcos Co., Ltd., Kacon extract powder * 10: Ichimaru Falcos Ougon extract powder manufactured by Co., Ltd. (manufacturing method) (1) to (6) are uniformly stirred and mixed.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Yuji Suzuki 3-28-1-102 Nakashizu, Sakura City, Chiba Prefecture (72) Inventor Yoshihiro Minematsu 2-9-1-303 Yamate, Funabashi City, Chiba Prefecture

Claims (1)

[Claims] 1. The following components (A) and (B) (A) L-ascorbic acid and one or more selected from the group consisting of water-soluble derivatives of L-ascorbic acid (B) Constrained root extract Whitening cosmetics.