JP2711782B2 - Whitening cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic, and more particularly to a whitening cosmetic which has an excellent skin whitening effect and can prevent and treat spots and freckles caused by sunburn.

[0002]

2. Description of the Related Art In general, skin spots and freckles are activated by melanocytes due to irritation caused by exposure to ultraviolet rays from sunlight, hormonal abnormalities, or genetic factors. Melanin pigments synthesized there are deposited in the skin. It is thought to be caused by abnormal deposition.

[0003] Conventionally, to prevent such skin spots and freckles, L-ascorbic acid and its derivatives,
Hydroquinone, arbutin, kojic acid, cysteine,
BACKGROUND ART Whitening cosmetics containing a melanin inhibitor such as glutathione or a placenta extract that acts on keratinocytes to provide a whitening effect have been used. However, these substances have problems in stability, safety, odor, and the like, and further, have a weak whitening effect, and a satisfactory whitening cosmetic has not yet been obtained.

[0004]

Therefore, there has been a demand for the development of a whitening cosmetic which has an excellent skin whitening effect, can treat spots and freckles, and can prevent its occurrence.

[0005]

In view of the above circumstances, the present inventors have made intensive studies and have found that one or more selected from the group consisting of L-ascorbic acid and water-soluble derivatives of L-ascorbic acid. The present inventors have found that the combination use of a Kakkon extract and a Kakkon extract enhances the whitening effect synergistically and can solve the above-mentioned problems, and have completed the present invention.

Accordingly, the present invention provides the following components (A) and (B): (A) one or more selected from the group consisting of L-ascorbic acid and a water-soluble derivative of L-ascorbic acid; It is intended to provide a whitening cosmetic containing a substance.

In the component (A) used in the present invention, the water-soluble derivative of L-ascorbic acid is not particularly limited as long as it is water-soluble, and for example, a monovalent metal salt of L-ascorbic acid phosphate ester L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, divalent metal salt L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, trivalent L which is a metal salt
-Ascorbic acid phosphate aluminum aluminum salt, and L-ascorbic acid sulfate monovalent metal salt L
-Ascorbic acid sulfate sodium salt, L-ascorbic acid potassium salt, divalent metal salt L-ascorbic acid sulfate magnesium salt, L-
Ascorbic acid sulfate calcium salt, trivalent metal salt L-ascorbic acid sulfate aluminum salt, and L-ascorbic acid monovalent metal salt L-
Preferred are sodium ascorbate, potassium L-ascorbate, divalent metal salts such as magnesium L-ascorbate, calcium L-ascorbate, and trivalent metal salts such as aluminum L-ascorbate. Can be mentioned.

In the present invention, the component (A) may be used alone or in combination of two or more, and 0.001 to 30% by weight, especially 0.1 to 30% by weight, based on the total amount of the cosmetic.
It is preferable to mix 1 to 5% by weight.

[0009] In addition, as the extract of radish of component (B) used in the present invention, pulp (Pueraria RAD) may be used.
IX) with a solvent such as water, ethanol, methanol, 1,3-butylene glycol, propylene glycol or a mixture thereof, an extract obtained by drying the extract, a dry powder obtained by drying the extract, or the extract One or a combination of two or more of each component such as an isoflavone derivative separated from the liquid can be used.

[0010] Here, as a particularly preferable extraction method of kakkon, for example, the method shown in the following Production Method 1 or Production Method 2 can be mentioned. (Manufacturing method: 1) For 1 kg of chopped dry matter,
Add 5 volumes of ethanol or methanol, and add
Perform reflux extraction for a time, perform filtration, concentrate the filtrate under reduced pressure,
By drying, a powder (the extract defined in the present invention) can be obtained. The yield is 5 when the extraction solvent is ethanol.
7 to 63 g, 90 to 110 g when using methanol
Degree is obtained. (Manufacturing method: 2) For 1 kg of dried chopped kakkon,
Add 5 times the volume of ethanol or methanol, stir occasionally, store at room temperature for about 3 days, filter, concentrate the filtrate under reduced pressure, and dry to obtain a powder (extract defined in the present invention).
Get. The yield is 30 to 30 when ethanol is used.
50 g, 90-100 g when using methanol
Degree is obtained. The extract obtained by the above-mentioned production method (extraction) is characterized by a high content of saccharides and puerarin. When the saccharides are converted into saccharose, the lower limit is 20.
%, The upper limit being about 45%. Puerarin having a range of 20 to 40% is obtained.

In the present invention, the component (B) is contained in the cosmetic in an amount of 0.001 to 10% by weight, especially 0.01% by weight in terms of dry matter.
Preferably, it is blended in an amount of about 5% by weight.

Further, the whitening cosmetic composition of the present invention is appropriately blended with various optional components used in ordinary cosmetics, quasi-drugs, pharmaceuticals, etc. other than the above essential components, as long as the effects of the present invention are not impaired. be able to. Such optional components include, for example, purified water, ethanol, oily substances, humectants, thickeners, preservatives, emulsifiers, medicinal ingredients, powders, ultraviolet absorbers, pigments, fragrances, emulsion stabilizers, pH adjusters and the like. Can be mentioned. Specifically, examples of the oily component include liquid paraffin, vaseline, paraffin wax, squalane, beeswax, carnauba wax, olive oil, lanolin, higher alcohols, fatty acids, synthetic ester oils of higher alcohols and fatty acids, and silicone oils. Examples thereof include sorbitol, xylitol, glycerin, maltitol, propylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, sodium pyrrolidonecarboxylate, lactic acid, sodium lactate, polyoxypropylene fatty acid ester, and polyethylene glycol. Examples of the thickener include water-soluble polymers such as carboxyvinyl polymer, carboxymethylcellulose, polyvinyl alcohol, carrageenan, and gelatin, and electrolytes such as sodium chloride and potassium chloride. Examples of the preservative include urea, methyl paraben, ethyl paraben, propyl paraben, butyl paraben, sodium benzoate, and the like.As the emulsifier, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester Non-ionic surfactants such as glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitol fatty acid ester, and the like, and talc, sericite, Mica, kaolin, silica, bentonite, vermiculite, zinc white, mica, mica titanium, titanium oxide, magnesium oxide, zirconium oxide, barium sulfate, red iron oxide, iron oxide, Blue, and the like. The whitening cosmetic of the present invention is preferably acidic to neutral (pH 7 or less) for system stability. Examples of the pH adjuster used here include buffers such as lactic acid-sodium lactate and citric acid-sodium citrate.

The whitening cosmetic of the present invention can be produced according to a conventional method. Further, the whitening cosmetics that are the subject of the present invention are not limited to general skin cosmetics, but include quasi-drugs, topical medicines, etc. It can be arbitrarily selected and may be in the form of cream, ointment, emulsion, lotion, solution, gel, pack, stick, or the like.

[0014]

EFFECT OF THE INVENTION The whitening cosmetic composition of the present invention has a synergistic inhibitory effect on melanin production by using L-ascorbic acid and / or a water-soluble derivative of L-ascorbic acid in combination with a Kakkon extract. It has an extremely excellent skin whitening effect and an effect of preventing and treating spots and freckles due to sunburn and the like.

[0015]

The present invention will be further described with reference to the following examples.
The present invention is not limited by these.

The evaluation of the whitening effect in the present embodiment is as follows.
The whitening effect test for UV-B-induced pigment spots shown below was performed. (Whitening Effect Test on UV-B-Induced Pigment Spot) Twenty test subjects were irradiated with ultraviolet rays in the UV-B region by irradiating twice the minimum erythema dose once a day for 2 days to the inner arm of 20 subjects. The whitening effect by continuously applying the sample to the test site twice a day on the pigmented spot for one month was examined. The evaluation was performed using a color difference meter (CMS-1200, manufactured by Murakami Color Co., Ltd.), the L * value was calculated from the obtained Munsell value, and the ΔΔL * value representing the recovery was used. The ΔΔL * value was defined as follows. The L * values of the sample-applied test site and the sample-unapplied test site immediately before the start of the sample application are respectively L ₀ , L ₀ ′,
One month after the continuous application, the L * value of each site was L ₁ ,
ΔL * is represented by the following equation as L ₁ '. ΔΔL * = (L ₁ −L ₀ ) − (L ₁ ′ −L ₀ ′) Further, the evaluation was shown by the average value of the evaluation points of 20 test subjects.

[0017]

[Table 1]

In the following examples, the compounding amount when a liquid crude drug extract is used is shown by weight% as a liquid. Example 1 A cream having the composition shown in Table 2 was prepared according to the following production method, and the whitening effect by continuous application was evaluated. Table 2 shows the results.

(Preparation method) The oil layer components [(1) to (6)]
The aqueous layer components [(7) to (15)] heated to 80 ° C. are added to the solution heated and dissolved at 0 ° C. while stirring and emulsified, and then (16) is added. Then, the mixture is cooled to room temperature with stirring.

[0020]

[Table 2]

From the results shown in Table 2, it can be seen that the cream of the present invention has an excellent whitening effect.

[0022]

Example 3 Cream (Composition) (% by weight) (1) Decaglyceryl stearate 1.8 (2) Polyoxyethylene cetyl ether 1.2 (3) Squalane 12.0 (4) Cetanol 6.0 (5) Cetyl palmitate 3.0 (6) 1,3-butylene glycol 6.0 (7) Glycerin 3.0 (8) Tetrasodium edetate 0.1 (9) L-ascorbic acid phosphate magnesium salt 3.0 (10) Kakkon extract ^{* 2} 0.3 (11) Citric acid / sodium citrate (25:75) 1.0 (Amount to adjust system pH to 5.8) (12) Purified water residue Amount (13) Preservative appropriate amount (14) Flavor appropriate amount pH: 5.8

* 2: Water layer heated to 80 ° C. with stirring in a solution obtained by heating and dissolving oil layer components [(1) to (5)] at 80 ° C., manufactured by Ichimaru Falcos Co., Ltd. After the components [(6) to (13)] are added and emulsified, (14) is added, and the mixture is cooled to room temperature with stirring.

[0024]

Example 3 Emulsion (Composition) (% by weight) (1) Polyoxyethylene sorbitan tristearate 1.0 (2) Glycerin oleate 1.0 (3) Glycerin monostearate 0.5 (4) Squalane 6.0 (5) Glyceryl trioctanoate 2.0 (6) Cetyl octoate 2.0 (7) Stearyl alcohol 2.0 (8) 1,3-butylene glycol 5.0 (9) Glycerin 3.0 (10 ) Xanthan gum 0.2 (11) Tetrasodium edetate 0.1 (12) Magnesium L-ascorbic acid phosphate ester 3.0 (13) Kakkon extract ^{* 3} 1.0 (14) Aloe extract ^{* 40} 5.5 (15) Citric acid / sodium citrate (10:90) 1.0 (the amount to adjust the pH of the system to 6.2) (16) Remaining purified water (17) Perfume appropriate amount ( 8) Preservative qs pH: 6.2

* 3: Cuckon extract powder, manufactured by Ichimaru Falcos Co., Ltd. * 4: Aloe MS (manufactured by Ichimaru Falcos Co., Ltd.) (Method of production) An oil layer component ((1) to (7)) heated and melted at 80 ° C. And the aqueous layer components [(8) to (16), (18)] heated to 80 ° C. with stirring and emulsified.
Add (17) and then cool to room temperature with stirring.

[0026]

Example 4 Essence (cosmetic) (composition) (% by weight) (1) 1,3-butylene glycol 8.0 (2) glycerin 4.0 (3) xanthan gum 0.3 (4) chondroitin sulfate 2. Sodium 0.1 (5) Sodium hyaluronate 0.05 (6) Ethanol 3.0 (7) Polyoxyethylene polyoxypropylene decyltetradecyl ether 0.3 (8) L-ascorbic acid phosphate magnesium salt 3. 0 (9) Kakkon extract ^{* 5} 0.1 (10) Mulberry bark extract ^{* 6} 1.0 (11) Citric acid / sodium citrate (15:85) 1.0 (pH of system is 6.0) (12) Tetrasodium edetate 0.1 (13) Remaining amount of purified water (14) Preservative appropriate amount (15) Flavor appropriate amount pH: 6.0

* 5: Ikkamaru Falcos Co., Ltd., Cuckon Extract Powder * 6: Ichimaru Falcos Co., Ltd., Falco Rex Sawhakuhi (solid content: 0.3-0.8% by weight) (Production method) (1)- After stirring and dispersing the component of (5), 65 parts of purified water is added to this and designated as A. On the other hand, (6),
After stirring and dissolving the components of (7), (14) and (15),
The remaining amount of purified water is added to this to make B. While stirring A, add B to make it uniform, then add the components (8) to (12) and stir and dissolve.

[0028]

Example 5 lotion (composition) (% by weight) (1) 1,3-butylene glycol 8.0 (2) glycerin 4.0 (3) sodium hyaluronate 0.1 (4) ethanol 3.0 (5) Polyoxyethylene polyoxypropylene decyltetradecyl ether 0.3 (6) Magnesium L-ascorbic acid phosphate ester 3.0 (7) Kakkon extract ^{* 7} 0.2 (8) Clove extract ^{* 8} 1.5 (9) Citric acid / sodium citrate (20:80) 1.0 (Amount to adjust system pH to 5.9) (10) Tetrasodium edetate 0.1 (11) Purified water residue Amount (12) Preservative appropriate amount (13) Fragrance appropriate amount pH: 5.9

* 7: Ikkamaru Falcos Co., Ltd., Cuckon Extract Powder * 8: Ichimaru Falcos Co., Ltd., Falco Rex Chouzi (solid content: 2.0 to 4.0% by weight) (Production method) (1) to After stirring and dispersing the component of (3), 60 parts of purified water is added to this and designated as A. On the other hand, (4),
After dissolving the components of (5), (12) and (13) with stirring,
The remaining amount of purified water is added to this to make B. While stirring A, add B to make it uniform, then add the components (6) to (11) and stir and dissolve.

[0030]

Example 6 Powder (composition) (% by weight) (1) Magnesium L-ascorbic acid phosphate 30.0 (2) Kakkon extract ^{* 9} 5.0 (3) Japanese gogon extract ^{* 10} 1 0.0 (4) Cetyl palmitate 10.0 (5) Hydrogenated soybean phospholipids 5.0 (6) D-mannitol 50.0 * 9: Cuckon extract powder manufactured by Ichimaru Falcos Co., Ltd. * 10: Ichimaru Falcos Co., Ltd., Ohgon Extract Powder (Production method) (1) to (6) are uniformly stirred and mixed.

Continuation of the front page (72) Inventor Yoshihiro Minematsu 2-9-1-303, Yamate, Funabashi-shi, Chiba (56) References JP-A-5-139949 (JP, A) JP-A-52-79032 (JP, A)

Claims (1)

(57) [Claims] 1. The following components (A) and (B): (A) one or more selected from the group consisting of L-ascorbic acid and a water-soluble derivative of L-ascorbic acid. Whitening cosmetics.