JP2000143479A - Skin-bleaching cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin-bleaching cosmetic which shows an excellent skin- bleaching effect and can sufficiently prevent and treat stains and freckles. SOLUTION: This skin-bleaching cosmetic is obtained by including (A) at least one kind of skin-bleaching agents selected from L-ascorbic acid or its derivatives, an extract from placenta and ellagic acid or its derivatives and (B) at least one kind of plant extracts selected from extracts from Rosae fructus and Sanguisorbae radix.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic having a skin whitening effect and an effect of preventing spots and freckles.

[0002]

2. Description of the Related Art Generally, skin spots and freckles are activated by melanocytes due to irritation caused by exposure to ultraviolet rays of the sun, hormonal abnormalities, or genetic factors. It is caused by abnormal deposition on the surface.

[0003] In the treatment of such spots and freckles, L-ascorbic acid and its derivatives, hydroquinone derivatives, kojic acid and its derivatives, placental extracts and the like having a melanin-inhibiting effect have been used.

[0004] However, all of these substances show only a weak melanin-suppressing effect. Therefore, when each of them is used alone in cosmetics or the like, a sufficient whitening effect and an effect of preventing spots and freckles cannot be obtained.

[0005]

SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to provide a whitening cosmetic which has an excellent whitening effect and can sufficiently prevent spots and freckles.

[0006]

Means for Solving the Problems The present inventors have proposed a whitening cosmetic which shows an excellent whitening effect and an effect of preventing spots and freckles by using a specific whitening agent in combination with a plant extract extracted from fruit or groundnut. Was obtained.

That is, the present invention relates to the following components (A) and (B): (A) at least one selected from L-ascorbic acid and its derivatives, hydroquinone derivatives, placental extracts, and ellagic acid and its derivatives An object of the present invention is to provide a whitening cosmetic containing one or more plant extracts selected from a whitening agent, (B) a fruit extract and an extract of Jiyu.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION Among the whitening agents of the component (A) used in the present invention, L-ascorbic acid and its derivatives include L-ascorbic acid, metal salts of L-ascorbic acid,
L-ascorbic acid phosphate metal salts, L-ascorbic acid sulfate metal salts and the like can be mentioned. Examples of the metal salt include respective Na, K, Mg, Ca, and Al salts.

Examples of the hydroquinone derivative include a condensate of hydroquinone and a sugar, and a condensate of an alkyl hydroquinone and a sugar in which one alkyl group having 1 to 4 carbon atoms has been introduced into hydroquinone. And the like are particularly preferred.

The placenta extract includes a water-soluble placenta extract which is generally used as a cosmetic raw material. For example, the placenta extract of mammals such as cows, pigs, and humans can be washed, blood removed, crushed, frozen, etc. After extracting the water-soluble component through the process, impurities are further removed.

Further, as ellagic acid and its derivatives,
For example, an ellagic acid compound or an alkali metal salt thereof can be mentioned as a preferable example (JP-A-1-7995).
No. 103). One or more of these whitening agents can be used, and it is particularly preferable to use L-ascorbic acid and its derivatives or placenta extracts. In the whitening cosmetic of the present invention, the content of these whitening agents is a whitening effect,
From the viewpoint of emulsification stability and feeling of use, 0.01 to 30% by weight
(Hereinafter simply indicated by%), particularly preferably 0.1%.
It is preferably from 0.01 to 10%, more preferably from 0.01 to 5%.

[0012] Of the plant extracts of component (B) used in the present invention, the fruit extract (Rose Fruit Extract) is ethanol, 1,3-, from pseudo-fruits or fruits of wild rose (Rose multiflora Thunberg) or a closely related plant thereof. It can be obtained by extraction with butylene glycol, water or a mixture thereof.

[0013] In addition, the Jinyu extract (Burnet Extract) is obtained by extracting from roots or rhizomes of Warm Mob (Sanguisorba officinalis L.) or its variants with ethanol, 1,3-butylene glycol, water or a mixture thereof. be able to.

The content of these plant extracts in the whitening cosmetic of the present invention is 0.00001 to 5% in terms of solid content in the total amount of whitening cosmetic from the viewpoint of whitening effect and storage stability.
In particular, 0.0005 to 3%, and more preferably 0.001 to 3%.

[0015] The whitening cosmetic composition of the present invention further comprises component (C) chamomile, tea, cuckoo, clove, licorice, loquat, orange peel, ginseng, peony, yamako, barley winter, ginger, matsukasa, mulberry. Peel, magnolia, clapper, asenyaku, yellow gon, aloe,
It is preferable to blend one or more plant extracts selected from extracts of Altea, Spiraea, Dutch mustard, kina, comfrey, rosemary, and funnel, since the whitening effect and the effect of preventing spots and freckles are improved. Among them, chamomile, tea, clove, licorice, peony, ginger, Altea, Dutch mustard, rosemary and funnel extract are preferred, and among them, chamomile, tea, clove,
Licorice, Altea extract is particularly preferred.

The plant extract of the component (C) can be used, for example, to remove leaves, roots, stems, trees, flowers, etc. of the plant from water or methanol, ethanol, propanol, propylene glycol, 1,3-butylene glycol, ethyl acetate or the like. It is obtained as an extract extracted with a hydrophilic organic solvent or a mixed solvent thereof, or the extract can be dried to obtain a dry powder. Furthermore, castor oil, persic oil, liquid paraffin, soybean oil, isopropyl myristate, lower fatty acid triglyceride, middle fatty acid triglyceride,
It can also be obtained by extraction with a lipophilic organic solvent such as sunflower oil, neopentyl glycol dicaprate, squalane, or a mixed solvent thereof.

In the present invention, when such a component (C) is used, its content is 0.00001 in terms of solid content in the total amount of the whitening cosmetic from the viewpoint of whitening effect and storage stability.
-5%, especially 0.0005-3%, more preferably 0.001-3
% Is preferred.

In the whitening cosmetic composition of the present invention, in addition to the above essential components, various optional components usually used in cosmetics, quasi-drugs, pharmaceuticals, and the like can be appropriately compounded as required.
Such optional components include, for example, water, ethanol,
Oily ingredients, humectants, thickeners, preservatives, emulsifiers, medicinal ingredients, powders, UV absorbers, pigments, fragrances, emulsion stabilizers, pH
And an adjusting agent.

The whitening cosmetic of the present invention can be produced according to a conventional method. In addition, the whitening cosmetic of the present invention is not limited to general skin cosmetics, quasi-drugs,
It includes external medicines and the like, and the dosage form can be arbitrarily selected according to the purpose, such as creams, ointments, emulsions, lotions, solutions, gels, etc. and forms such as packs, powders, sticks, etc. It can be.

[0020]

The whitening cosmetic composition of the present invention is excellent in skin whitening effect and can sufficiently prevent and treat spots and freckles caused by sunburn.

[0021]

EXAMPLES Examples 1 to 6 and Comparative Examples 1 to 6 (Cream) Creams having the compositions shown in Tables 2 and 3 were produced and evaluated for their whitening effect. The results are shown in each table.

(Preparation method) The oil phase component is heated and dissolved at 80 ° C.
The aqueous phase component heated to 60 ° C. was added with stirring, and further cooled to room temperature with stirring to obtain a cream.

(Whitening Effect Test for UV-B-Induced Pigmented Spot) Induction of UV-B-region ultraviolet rays by irradiating twice the minimum erythema amount once a day for 2 days to the inner arm of 20 subjects A sample was continuously applied to the pigmented spots (twice a day, 1
) For whitening effect. For evaluation, colorimetry was performed using a color difference meter (CMS-1200 manufactured by Murakami Color Co., Ltd.), an L ^* value was calculated from the obtained Munsell value, and a ΔΔL ^* value indicating the recovery was used. The ΔΔL ^* value was defined as follows. L ^* of the sample application test site immediately before the start of the sample application and the L ^* of the sample application site where the sample is not applied are respectively L ₀ , L ₀ ^′ ,
One month after continuous application, the L ^* value of each part was L ₁ ,
ΔL ^* was expressed by the following equation as L ₁ ^′ . ΔΔL ^* = (L ₁ −L ₀ ) − (L ₁ ^′ −L ₀ ^′ ) The evaluation was shown by the evaluation points shown in Table 1 as an average value of 20 subjects.

[0024]

[Table 1]

[0025]

[Table 2]

[0026]

[Table 3]

From the results shown in Tables 2 and 3, it is understood that the whitening cream of the present invention has a synergistically improved whitening effect by the combination of the components (A) and (B).

Example 7 (Emulsion) An emulsion having the following composition was produced by a conventional method. The obtained emulsion was excellent in whitening effect and could prevent and treat spots and freckles. (Components) (% by weight) Polyoxyethylene sorbitan tristearate 1.0 Glycerin oleate 1.0 Glycerin monostearate 0.5 Squalane 6.0 Glyceryl trioctanoate 2.0 Cetyl octanoate 2.0 Stearyl alcohol 0 1,3-butylene glycol 3.0 glycerin 1.0 Sodium hyaluronate 0.2 Tetrasodium edetate 0.1 Arbutin (same as * 2) 3.0 Jiyu extract (same as * 6) 0 .5 Tea extract (Ryokucharikid (Ichimaru Falcos)) 0.1 Sodium citrate 0.5 Deionized water Remaining amount Perfume Appropriate Preservative Appropriate

Example 8 (Essence) An essence having the following composition was produced by a conventional method. The obtained essence was excellent in whitening effect and could prevent and treat spots and freckles. (Components) (% by weight) 1,3-butylene glycol 8.0 glycerin 4.0 carboxyvinyl polymer (Carbopol 981 (manufactured by Goodrich)) 0.1 Acrylic acid / alkyl methacrylate copolymer (Pemrene TR- 2 (manufactured by Goodrich)) 0.2 L-arginine 0.3 sodium hyaluronate 0.05 ethanol 3.0 polyoxyethylene polyoxypropylene tetradecyl ether 2.0 L-ascorbic acid phosphate magnesium (* 3.0 Same as above 3.0 3.0 Fruit extract (same as the above * 5) 0.5 Licorice extract (oil-soluble licorice extract PT (40) (Maruzen Pharmaceutical Co., Ltd.)) 0.01 Citric acid 0.15 Sodium citrate 0.85 Tetrasodium edetate 0.1 Ion-exchanged water Remaining amount Perfume Appropriate Preservative Appropriate

Example 9 (Lotion) A lotion having the following composition was produced by a conventional method. The obtained lotion was excellent in whitening effect and could prevent and treat spots and freckles. (Components) (% by weight) 1,3-butylene glycol 8.0 Glycerin 4.0 Sodium hyaluronate 0.1 Ethanol 3.0 Polyoxypropylene decyl tetradecyl ether 0.3 Beef placenta extract (same as the above * 4) 1.0 Real extract (same as * 5 above) 0.5 Jiyu extract (same as * 6 above) 0.5 Clove extract (Falcolex Chowge (Ichimaru Falcos)) 0.5 Citric acid Sodium 1.0 Tetrasodium edetate 0.1 Ion-exchanged water Remaining amount Flavoring amount Preservatives

Example 10 (Pack) A pack having the following composition was produced by a conventional method. The obtained pack was excellent in whitening effect and could prevent and treat spots and freckles. (Components) (% by weight) Dipropylene glycol 3.0 Polyethylene glycol 3.0 1,3-butylene glycol 1.0 Glycerin 2.0 Sodium pyrrolidonecarboxylate 1.0 Sodium citrate 1.0 Disodium edetate 1 Ellagic acid (same as * 3 above) 1.0 Working extract (same as * 5 above) 0.5 Altea extract (same as * 8 above) 0.5 Lactic acid 0.5 Polyvinyl alcohol 12.0 Polyoxy Ethylene polyoxypropylene decyl tetradecyl ether 0.3 Preservative qs perfume qs Deionized water balance

Example 11 (Stick) A stick having the following composition was produced by a conventional method. The obtained stick was excellent in whitening effect and could prevent and treat spots and freckles. (Component) (% by weight) Magnesium L-ascorbate phosphate (same as * 1 above) 1.0 Arbutin (same as * 2 above) 1.0 Real extract (same as above * 5) 0.2 Chamomile Extract (same as * 7 above) 0.2 Microcrystalline wax 5.0 Polyethylene wax 10.0 Fine zinc oxide 5.0 Titanium oxide 10.0 Sericite 30.0 Mica 10.0 Kaolin 5.0 Bengala 2. 0 Iron oxide yellow 2.5 Black iron oxide 0.1 Polyoxyethylene hydrogenated castor oil (HCO-10) 5.0 Liquid paraffin 6.0 Triglyceride isostearate 5.0 Isotridecyl isononanoate 2.0

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7 / 00K (72) Inventor Hiroshi Kusunoki 2606 Kabanecho, Kaga-cho, Haga-gun, Tochigi Kao Stock In-house research institute (72) Inventor Yusuke Shibuya 2606, Kabane-cho, Akaga-cho, Haga-gun, Tochigi In-house research institute (72) Person Akemi Kobayashi 2606 Akabane, Kakaicho, Haga-gun, Tochigi Pref. AD161 AD332 AD392 AD641 AD642 CC03 DD11 DD17 DD28 DD31 EE16

Claims (2)

[Claims] 1. The following components (A) and (B): (A) one or more whitening agents selected from L-ascorbic acid and its derivatives, hydroquinone derivatives, placental extracts and ellagic acid and its derivatives, B) A skin-whitening cosmetic containing one or more plant extracts selected from the extract of fruit and Jiyu. 2. Ingredient (C) chamomile, tea, kakkon, cloves, licorice, loquat, orange peel, ginseng, peony, Yamashiko, barley winter, ginger, matsukasa, mulberry bark, magnolia, magnolia, achinko 2. The whitening cosmetic according to claim 1, wherein the whitening cosmetic comprises one or more plant extracts selected from extracts of herbal medicine, yellow gon, aloe, altea, spiraea, Dutch mustard, kina, comfrey, rosemary and funnel.