JPH09227353A - Skin whitening cosmetic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic composition containing, as active ingredients, plant extracts, excellent in safety and stability, and having high skin whitening effect. SOLUTION: This skin whitening cosmetic composition contains, as active ingredients, >=0.0001wt.% of plant extracts A, B and C, namely: (A) bark of Morus bombycis extract derived from the root bark of mulberry, (B) licorice extract derived from the root of Lagminosae plant as a kind of perennial plant, and (C) at least one kind of extract selected from those derived from scutellariae radix as the dried root of Scutellaria baicalensis belonging to Labiatae, sophora flower as the dried bud of sophora belonging to Lagminosae, peach blossom as the dried bud of peach belonging to Rosaceae, dried daphne flower belonging to Daphne odora, and sophorae radix as the dried root of Sophora angustifolia belonging to Lagminosae. The weight ratio A:B:C is (1-5):(1-5):(1-5), pref. 1:1:1. In this cosmetic composition, use of a combination of three or more kinds of the above-mentioned highly safe extracts derived from readily available specific plants enhances skin whitening effect synergistically.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a whitening cosmetic composition having excellent safety and stability and having a high whitening effect.

[0002]

2. Description of the Related Art Conventionally, whitening cosmetic compositions, that is, whitening cosmetics, include reducing agents such as sulfur, hydrogen peroxide, vitamin C and vitamin C derivatives, and arbutin,
Many are known to contain placenta extract and the like.

However, it has been difficult to say that these raw materials for whitening cosmetics are excellent in stability in terms of quality due to discoloration or precipitation of the preparation after long-term storage. In recent years, placenta extract, which tends to be of natural origin, is one of the raw materials for whitening cosmetics.
Since it is an extract obtained from placenta such as pig, there was a problem in supply.

On the other hand, it is also known to use a plant extract as a raw material for a whitening cosmetic composition which does not have the above-mentioned problems. For example, JP-A-6-107532 discloses a whitening cosmetic containing a tea extract and the like. Further, JP-A-64-83009 discloses an external preparation for suppressing melanin production containing a crude drug such as cinnamon.

[0005]

However, the whitening effect of the plant extract itself has not always been sufficient in the white cosmetics and external preparations using the plant extract known so far. . That is, the above-mentioned JP-A-6-
Even with the whitening cosmetics disclosed in Japanese Patent No. 107532,
An ultraviolet absorber and an ultraviolet scatterer are essential components together with plant extraction, and it is an essential condition to use kojic acid or its ester together in the external preparation disclosed in JP-A-64-83009. There is.

Therefore, an object of the present invention is to provide a whitening cosmetic composition having a high whitening effect by using a plant extract, which is safe for the human body, as an essential whitening ingredient.

[0007]

Means for Solving the Problems The inventors of the present invention have conducted extensive studies to find a composition which is of plant origin, is safe for the human body, and has an excellent whitening effect. By using three or more kinds of highly safe plant extracts extracted from plants in combination, the whitening effect is synergistically enhanced and a high whitening effect never obtained by itself is obtained. The present invention has been completed and the present invention has been completed.

That is, the whitening cosmetic composition of the present invention comprises
(A) Sophoraceae extract, (B) Licorice extract,
(C) An extract of at least one or more plants selected from the group consisting of sardines, squid, bald mosquitoes, mosquitoes, and kujin.

Component weight ratio of the extract (A) :( B):
(C) is preferably in the range of 1-5: 1 to 5: 1-5, and more preferably 1: 1: 1.

[0010]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention will be specifically described below. The extract component (A) Sohakuhi (mulberry bark) to be added to the whitening cosmetic composition of the present invention refers to one in which the root bark is dried with Morus bombycis of the mulberry family used as a diuretic. In addition, licorice (licorice), which is an extract component (B), is a Glycyrrhiza glabra var.
It refers to those that use fera or G. uralensis roots.

[0011] Also, one of the extracted components (C) is sardine (yellow rice), which has a height of 1 m used as an anti-inflammatory drug.
Scutellaria baical of the Labiatae family
It is used by drying the roots of ensis without the skin. In addition, the squid (Souka) is a deciduous tree that is used as a hemostatic agent, and is used by drying the buds of the legume Sophora japonica. In addition, Bald mosquito (white peach blossom) is a peach of the family Rosaceae used as a laxative.
The one that uses ersica buds. In addition, Zuikouka (Mizuka) is a dried flower of Daphne odora, which is used as an anti-inflammatory drug. Furthermore, Kuzin
Is a 1.5-meter-high perennial legume Clara Sophora flavescens used as a stomachic / diuretic drug or
S. angustifolia roots are used as they are or those with most of the pericarp removed. The extraction component (C) is an extract of at least one plant selected from the group consisting of these plants.

The whitening cosmetic composition of the present invention essentially comprises the extractive components (A), (B) and (C) obtained from the above-mentioned plants, and is a mixture of plant extractaceous substances composed of these components. Refers to whitening cosmetics.

As a method for extracting each plant extract component,
The solvent is not particularly limited, and any solvent such as water, alcohol, polyhydric alcohol, hexane, ethyl acetate, or any mixed solution can be appropriately used. Examples of alcohols used herein include ethanol, and examples of polyhydric alcohols include 1,3-butylene glycol, propylene glycol, and glycerin. Also, if necessary, heat treatment, cooling treatment, concentration, adsorption purification,
Separation and purification operations such as filtration can be performed.

Weight ratio (A) of the above plant extract components:
(B) :( C) is preferably 1-5: 1-5: 1-5
And more preferably 1: 1: 1. If the weight ratio of these three components deviates from the above range, the synergistic action of the whitening effect will be reduced, and it will be almost the same as the whitening effect obtained by a single plant extract component.

When the mixture of the plant extract components (A), (B) and (C) is blended as a whitening component of a whitening cosmetic, the amount is 0.0001% by weight or more based on the whole whitening cosmetic. To do so. If it is less than 0.0001% by weight, the enhancing effect of the whitening effect cannot be said to be sufficient.

In addition, the whitening cosmetic composition of the present invention may contain any component other than the above components within a qualitative and quantitative range that does not impair the effects of the present invention. Ingredients usually added to foods, such as purified water, ethanol, oils, surfactants, humectants, preservatives, perfumes, and other various additives can be added.

Examples of oil agents include hydrocarbons such as liquid paraffin and squalane, ester oils such as isopropyl myristate and cetyl octanoate, fatty acids, silicone oils and animal and vegetable oils, and surfactants include sorbitan fatty acid esters and glycerin fatty acid esters. , Polyoxyethylene hydrogenated castor oil, nonionic surfactants such as sucrose fatty acid esters, anionic surfactants such as fatty acid salts, alkyl sulfates, N-acyl amino acid salts, betaine acetate,
Examples include amphoteric surfactants such as lecithin and cationic surfactants.

As the moisturizers, polyhydric alcohols such as glycerin, propylene glycol and 1,3-butylene glycol, sugar alcohols such as sorbit and mannitol, polyethylene glycol, xanthan gum, polyacrylic acid salts and hyaluronic acid salts can be used. Water-soluble polymer, urea,
Examples include sodium lactate and pyrrolidone carboxylate, and examples of the preservative include parabens and benzoate. Furthermore, as other additives, various vitamins,
A chelating agent, a colorant, an animal or plant extract, a thickener, an ultraviolet absorber, a medicinal component, etc. can be added. Further, the dosage form of the whitening cosmetic composition of the present invention is arbitrary, and for example, a solubilization system such as a lotion, an emulsion system such as an emulsion or a cream, or an ointment, a dispersion, a gel form or the like is used. be able to.

[0019]

EXAMPLES Next, the present invention will be described more specifically with reference to Examples. (Preparation example of plant extract) The plant name, extraction solvent and extraction form of the extracted plant used in the following Examples and Comparative Examples are shown in Table 1 below. Using the plant and the extraction solvent, the respective plant extracts were obtained according to a conventional method.

[0020]

[Table 1]

(Examples 1 to 6, Comparative Examples 1 to 7)
The various plant extracts A to G prepared as described above were combined as shown in Table 2 below to form a mixture, and the anti-tyrosinase activity of these was measured by the dopachrome assay method. The test method is 1 / 15M phosphate buffer (pH
6.8) 2.0 ml, 0.1% test aqueous solution 2.0 ml,
15,000 units / 100 ml tyrosinase / 0.5 ml saline solution was incubated at 37 ° C,
0.5 mg / ml L-tyrosine · 7N / 1000 potassium hydroxide · phosphate buffer 0.5 ml was added, and the absorbance (475 nm) after 1 hour was measured. For comparison, a mixture of plant extracts A and B and water, plant extract A alone, plant extract B alone, water, placenta extract, arbutin (reagent), and vitamin C (reagent) were used. The results obtained are shown in Table 2 below.

[0022]

[Table 2] Incidentally, inhibition rate (%) is the minus the absorbance A _s measured sample from the absorbance A _b measured with water divided by A _b, 1
It was calculated by multiplying by 00.

As is clear from Table 2, all of Examples 1 to 6 showed an inhibition rate of about 90% or more, whereas Comparative Examples showed a comparison between plant extracts A and B and a mixture of water. Even in Example 1, it was only 76%.

Examples 7 to 11 and Comparative Examples 8 to 10 Next, whitening lotions, whitening creams and whitening packs were prepared by using the mixture of various plant extracts shown in Table 2 according to the following formulation.

Example 7 (whitening lotion) 1,3-butylene glycol 5.0% by weight paraoxybenzoic acid ester 0.25 polyoxyethylene oleyl ether 1.0 extract mixture of Example 1 0.001 purified water Moderate amount ─────────────────────────────── 100.0

Example 8 (Whitening lotion) 1,3-butylene glycol 5.0% by weight paraoxybenzoic acid ester 0.25 polyoxyethylene oleyl ether 1.0 Extract mixture of Example 4 0.001 Purified water Moderate amount ─────────────────────────────── 100.0

Example 9 (Whitening lotion) 1,3-butylene glycol 5.0 wt% paraoxybenzoic acid ester 0.25 polyoxyethylene oleyl ether 1.0 Extract mixture of Example 6 0.001 Purified water Moderate amount ─────────────────────────────── 100.0

Comparative Example 8 (Comparative Lotion) 1,3-Butylene glycol 5.0% by weight Paraoxybenzoic acid ester 0.25 Polyoxyethylene oleyl ether 1.0 Extract mixture of Comparative Example 1 0.001 Purified water Moderate amount ─────────────────────────────── 100.0

Comparative Example 9 (Comparative Lotion) 1,3-butylene glycol 5.0% by weight Paraoxybenzoic acid ester 0.25 Polyoxyethylene oleyl ether 1.0 Arbutin of Comparative Example 3 0.5 Purified water Suitable amount ── ───────────────────────────── 100.0

Comparative Example 10 (Comparative lotion) 1,3-butylene glycol 5.0% by weight paraoxybenzoic acid ester 0.25 polyoxyethylene oleyl ether 1.0 purified water appropriate amount ─────────── ───────────────────── 100.0

Example 10 (Whitening cream) Beeswax 6.0 wt% cetanol 5.0 reduced lanolin 8.0 squalane 37.5 fatty acid glycerin 4.0 lipophilic glyceryl monostearate 2.0 polyoxyethylene sorbitan monolauric acid Ester (20EO) 2.0 Fragrance 0.5 Paraoxybenzoic acid ester 0.25 1,3-butylene glycol 5.0 Extract mixture of Example 1 0.001 Purified water Appropriate amount ────── ───────────────────────── 100.0

Example 11 (Whitening pack (peel-off type)) Ethanol 10.0% by weight Paraoxybenzoic acid ester 0.25 Perfume 0.5 1,3-Butylene glycol 3.0 Polyvinyl alcohol 15.0 Carboxymethylcellulose sodium 5. 0 Extract mixture of Example 1 0.001 Purified water Appropriate amount ──────────────────────────────── 100.0

Each lotion obtained in Examples 7 to 9 and Comparative Examples 8 to 10 was applied to 24 women (8 people x 3 groups) twice a day in the morning and evening. After continuous use for a month, the skin condition after that was investigated. Examples 7-9
As described above, the lotion of Example 1 contains the mixture of plant extracts of Examples 1, 4, and 6, and the lotions of Comparative Examples 8 to 10 include those of Comparative Examples 1, 3, and 7, respectively. It is compounded.
The results obtained are shown in Table 3 below. The criteria used here are-: 0 (no effect is recognized), ±: 1 (slight effect is recognized), and +: 2 (effect is recognized). In the total column, the total number of points (number of people) was entered for each sample.

The test subject was a person who recognized pigmentation symmetrically on the face. All external preparations that have an effect on reducing pigmentation were prohibited, and oral preparations were allowed to use vitamin C or tranexamic acid. Further, the subject was informed that both the whitening lotion of the invention and the lotion of the comparative product were whitening lotions, and the blinding method was performed.

[0035]

[Table 3]

The cosmetic preparations obtained in Examples 7 to 11 and the plant extract mixtures obtained in Examples 1 to 6 were subjected to a patch test (sealing patch test) and a photo of 30 healthy female subjects. Patch test (optical sticking test: UV-
A) was performed. 48, 72 hours after the patch test, 24, 48 after the photo patch test
The judgment was made after a lapse of time. The criteria for evaluation were four levels: −: no change was observed, ±: extremely redness was very weak, +: redness was clearly observed, and ++: strong redness with swelling, papules, and blisters was observed. As a result, for each of the cosmetic preparations of Examples 7 to 11, no more than + was recognized, and ± was one. Further, also with respect to the plant extract mixtures of Examples 1 to 6, no more than + was recognized, and ± was also two.

[0037]

As described above, in the whitening cosmetic composition of the present invention, three or more kinds of highly safe plant extracts extracted from specific plants that are easily available are combined. By using it, the whitening effect is synergistically enhanced and it has an excellent whitening effect.

 ──────────────────────────────────────────────────の Continued on the front page (72) Inventor Normal Shigematsu 392 Tsukiji, Fujieda-shi, Shizuoka Pref.

Claims (3)

[Claims] 1. (A) Sophoraceae extract, (B) Licorice extract, (C) Ogon, Kaika, Hakutoka,
A whitening cosmetic composition comprising: an extract of at least one plant selected from the group consisting of Zuzuka and Kujin. 2. The component weight ratio (A) of the extract:
The whitening cosmetic composition according to claim 1, wherein (B) :( C) is in the range of 1 to 5: 1 to 5: 1 to 5. 3. The component weight ratio (A) of the extract:
The whitening cosmetic composition according to claim 2, wherein (B) :( C) is 1: 1: 1.