JP4800049B2 - Formulation for activating mTOR and method for activating mTOR - Google Patents

Description

  The present invention relates to a novel preparation for activating mTOR, which is an important factor, and a method for activating it in order to prevent skin aging caused by ultraviolet rays or aging.

  Mammalian target of rapamycin (mTOR) is a 290 kDa serine-threonine protein phosphatase consisting of about 2500 amino acids (known as a member of the ATM kinase family). As shown in FIG. 1, the signal transduction system via mTOR is two important transcriptional regulators that mTOR acts as a sensor of amino acid balance in the cellular environment in mammals and is involved in the translation of cell cycle regulatory proteins. By regulating the activities of S6 kinase 1 (S6K1) and initiation factor 4E binding protein (4E-BP1) (Non-patent document 1 and Non-patent document 2), protein synthesis, mRNA transcription and translation, cell cycle regulation, It is known to be involved in protein degradation and cell growth (cell size) (Non-patent Documents 3 and 4).

Burnett, PE. , PNAS, 95, 1432 (1998) Isotani, S. , J .; Biol. Chem. , 274, 33493 (1999) Gingras et al. Genes & Dev. , 15, 807 (2001) Fingar and Blenis, Oncogene, 23, 3151-3171 (2004)

Several associations with mTOR have also been suggested for cell differentiation. For example, the present inventors have found that phospholipase D1 (PLD1) negatively regulates melanin biosynthesis via mTOR / S6K1 signal in pigment cells. PLD1 is an enzyme that produces phosphatidic acid (PA) from phosphatidylcholine, and phosphatidic acid itself or its metabolite functions as an important second messenger in the intracellular signal transduction system. So far, it has been reported that mTOR is a target molecule of phosphatidic acid produced by PLD1 (Non-patent Documents 5 and 6). And the expression level and enzyme activity of PLD1 decrease remarkably in inverse correlation with the increase of melanin biosynthesis by α-MSH, and activation of PLD1 suppresses melanin synthesis in B16 melanoma cells. Furthermore, it has been reported that knocking down the PLD1 gene decreases mTOR activity (phosphorylation of S6K1), resulting in enhanced expression of tyrosinase and tyrosinase-related enzymes and activation of melanin biosynthesis (non-patented) Document 7 and Non-Patent Document 8). From these findings, it is considered that the PLD1 / PA / mTOR / S6K1 signal is deeply involved in the control system of melanin synthesis in pigment cells.

Fang et al. , Science, 294, 1942-1945 (2001) Kam and Exton, FASEB J, 18, 311-319 (2004) Oguchi et al. Biol. Chem. , 279, 3408-3412 (2004) Oguchi et al. Cell. Physiol. , 205, 444-451 (2005)

  On the other hand, it is already known that transmitters such as α-MSH, histamine, and endothelin-1 secreted from the epidermis by ultraviolet rays increase cAMP in pigment cells and promote melanin synthesis (Non-patent Document 9). Non-patent document 10 and Non-patent document 11). As a pathway different from the PLD1 / PA / mTOR / S6K1 that shifts from the production of cAMP, a pathway via phosphatidylinositol 3 kinase (PI3K) shown in FIG. 1 is known. PI3K is an enzyme that phosphorylates phosphatidylinositol (PI), and the produced phosphorylated inositol (PIP2, PIP3, etc.) is known to function as an important second messenger in the intracellular signal transduction system, as in PA. . By using a specific inhibitor of PI3K (LY294002) so far, the melanin synthesis is promoted in B16 melanoma cells, and the production of cAMP using forskolin is promoted, so that the activity of PI3K and S6K1 is enhanced. It has been reported that inhibition and tyrosinase expression are enhanced (Non-patent Document 12). Akt, which is a serine / threonine kinase, is a target protein of PI3K, and it has been reported that PI3K / Akt signal regulates the activity of mTOR located downstream (Non-patent Document 13 and Non-patent Document 14). . Therefore, from the above knowledge, mTOR is considered to play an important role as a target molecule for controlling melanin synthesis through two types of phospholipid metabolic signaling of PLD1 / PA pathway and PI3K / Akt pathway.

Yoshida M et al. , J .; Invest. Dermatol. , 114, 334-342 (2000) Suzuki I et al., Endocrinology, 137, 1627-1633 (1996) Imokawa G et al., J Biol. Chem., 267, 24675-24680 (1992) Busca R et al. , J .; Biol. Chem. , 271, 31824-31830 (1996) Gingras AC et al. Genes & Dev. , 15, 807 (2001) Fingar and Blenis, Oncogene, 23, 3151-3171 (2004)

Rapamycin, which is a selective inhibitor of mTOR, is known to suppress collagen biosynthesis in dermal fibroblasts (Non-patent Document 15). Furthermore, the present inventors have found that overexpression of PLD1 promotes collagen synthesis in dermal fibroblasts, and that knockdown of PLD1 reduces phosphorylation of S6K1 and type I collagen mRNA levels. . Therefore, it has been suggested that PLD1 is involved in the control of collagen synthesis via the mTOR / S6K1 signal transduction system (Non-patent Document 16).

Shegogue D et al. , J .; Biol. Chem. , 279, 23166-23175 (2004) Oguchi et al., Abstracts of 2005 Annual Meeting of the Biochemical Society, Biochemistry 77, 931 (2005)

  Based on the above findings, mTOR and mTOR-mediated signal transduction systems not only regulate protein synthesis, mRNA transcription and translation, cell cycle regulation, protein degradation, cell growth (cell size), but also skin fibers. It is thought to be involved in various physiological functions such as collagen synthesis in blast cells and melanin synthesis in pigment cells. And the regulation of mTOR and mTOR-mediated signal transduction system activity depends on ultraviolet rays or aging in addition to medical fields such as analysis of pathological conditions involving cell proliferation / growth, development of therapeutic agents, and improvement of treatment. It is expected to make important contributions in the cosmetics field, such as improving skin aging such as wrinkles, sagging and spots.

  Rapamycin has been known as a selective inhibitor of mTOR so far, and phosphatidic acid (Non-patent Document 17) and amino acids (Non-patent Document 18) including leucine are included as components that activate mTOR. It has only been reported. However, phosphatidic acid and leucine do not fully activate mTOR or mTOR / S6K1 signal, and phosphatidic acid has low solubility in water and nonpolar solvents, making it difficult to formulate. It also has some problems.

Fang Y et al. , Science, 294, 1942-1945 (2001) Christopher JL et al. , Am. J. Physiol. Endocrinol. Metab. , 285, 854-863 (2003)

  Therefore, the subject of the present invention is the development of a preparation that activates mTOR or a method of activating mTOR, which has hardly been found in the past.

  The inventors of the present invention have found that moxa jelly extract, Ibukitorano extract, gosho strawberry extract, white willow extract, kikarasuuri extract and alpinia katsudai extract have an excellent mTOR activation effect. Accordingly, the present invention provides a preparation for activating mTOR comprising a specific compound as an active ingredient and a method for preventing skin aging using a preparation for activating mTOR.

  The preparation of the present invention has a strong effect of activating mTOR. In addition, by utilizing this action of activating mTOR, it is possible to produce a preparation used for preventing skin aging caused by ultraviolet rays or aging. Furthermore, by using a preparation that activates mTOR, a new method for preventing skin aging caused by ultraviolet rays or aging can also be provided.

  The cowpea extract used as an active ingredient in the preparation of the present invention is obtained by extracting a fruit of Catalpa ovata G. Don. With a solvent as it is or after pulverization. Optimally, it is an extract of the specific part, but other parts (e.g., flowers, styles, male flowers, female flowers, spikes, head flowers, fruits, fruit, fruits, stems, leaves, branches, branches, stems, bark, Extracts of roots, rhizomes, root barks, seeds, etc.) can be used in the same manner only if they have an action of activating mTOR.

The Ibuquitorano extract used as an active ingredient in the preparation of the present invention is obtained by extracting the rhizome (Polygonum bistorta L.) rhizome (Polygonum bistorta L.) as it is or after pulverizing and extracting with a solvent. Optimally, it is an extract of the rhizome, but other parts (eg flowers, styles, male flowers, female flowers, spikes, head flowers, fruits, pericarp, fruits, stems, leaves, branches, branches, stems, bark, seeds. Etc.) can also be used in the same manner as long as they have the action of activating mTOR.

  The Gosho strawberry extract used as an active ingredient in the preparation of the present invention is obtained by extracting a fruit of Rubus chingii Hu (herbal medicine name: Fukubonshi) as it is or after pulverization and extracting with a solvent. In addition, Rubus crataegifolius Bge. Or Rubus coreanus Miq. Genus species can be selected. Optimum is an extract of the fruit, but other parts (eg flowers, styles, male flowers, female flowers, spikes, head flowers, stems, leaves, branches, branches and leaves, trunks, bark, roots, rhizomes, root barks, seeds) Etc.) can also be used in the same manner as long as they have the action of activating mTOR.

  The white willow extract used as an active ingredient in the preparation of the present invention is obtained by extracting the bark of the willow family Willow (Salix alba L.) with or without pulverization. Optimally, it is an extract of the specific part, but other parts (for example, flowers, styles, male flowers, female flowers, spikes, head flowers, stems, leaves, branches, branches and leaves, trunks, bark, roots, rhizomes, root barks, The extract of seeds and the like) can be used in the same manner only when it has an action of activating mTOR.

  The extract of the cucumber cucumber used as an active ingredient in the preparation of the present invention is a seed (herb medicine name caronine) or root (herb medicine name carocon) of cucurbitaceae (Trichosanthes kirilowii Maxim. Var. Japonica. (Miq.) Kitam.). Is extracted with a solvent as it is or after pulverization. Optimum is an extract of the seeds or roots, but other parts (eg flowers, styles, male flowers, female flowers, flower spikes, head flowers, fruits, pericarps, fruits, stems, leaves, branches, branches, stems, bark Etc.) can also be used in the same manner as long as they have the action of activating mTOR.

  The Alpinia katsumadai extract used as an active ingredient in the preparation of the present invention is obtained by extracting seeds (Alpinia katsumadai Hayata) of the ginger family Alpinia katsumadai Hayata as they are or after pulverizing them with a solvent. Optimum is an extract of the seeds, but other parts (eg flowers, styles, male flowers, female flowers, spikes, head flowers, grapes, pericarp, fruits, stems, leaves, branches, branches and leaves, trunks, bark, roots) The extract of rhizome, root bark, etc.) can be used in the same manner as long as it has an action of activating mTOR.

  As an extraction solvent for obtaining each extract used in the present invention, water, lower alcohol such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol or the like, hydrous lower alcohol, propylene glycol, 1,3-butylene glycol 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,3,5-pentane Polyols such as triol, glycerin, polyethylene glycol (molecular weight 100 to 100,000) or hydrous polyhydric alcohols, acetone, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, tetrachloride Carbon, phenol, toluene, etc. It is selected from various organic solvents, acids (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.) prepared as appropriate One type or a mixture of two or more types can be mentioned, and it is particularly preferable to select one type or two or more types selected from water, ethanol and 1,3-butylene glycol. However, if it is not preferable to use a solvent depending on the application, use water alone or extract with a highly volatile solvent that is easy to remove the solvent after extraction and dissolve in water after removing the solvent. Such a method is also possible.

  Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. Although it can set arbitrarily as the temperature of a solvent in the range of -4 degreeC to 100 degreeC, 10-40 degreeC vicinity is preferable from the point of stability of the component contained in a raw material. Also, the weight ratio of the solvent to the raw material can be arbitrarily set, for example, in the range of the raw material: solvent 4: 1 to 1: 100, and the weight ratio of 1: 1 to 1:20 is particularly preferable.

  Each extract used in the present invention can be further subjected to a purification operation after solvent extraction. As the purification operation, acid (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, organic acid, etc.) or alkali (hydroxylation) is used. Decomposition by addition of sodium, calcium hydroxide, ammonia, etc., fermentation or metabolic conversion by microorganisms, component adsorption by ion exchange resin, activated carbon, diatomaceous earth, etc., various separation modes (ion exchange, hydrophilic adsorption, hydrophobic adsorption, Fractionation using chromatography with size exclusion, ligand exchange, affinity, etc., filtration using filter paper, membrane filter, ultrafiltration membrane, etc., pressurization or decompression, heating or cooling, drying, pH adjustment Deodorization, decolorization, long-time standing storage, etc. can be exemplified, and these can be arbitrarily selected and combined.

  In producing the preparation of the present invention, the shape of each extract to be used may be any shape such as liquid, solid, powder, paste, etc., and an optimal shape for carrying out the present invention is arbitrarily selected. You can choose.

  The content of each extract in the preparation of the present invention is not particularly limited as long as activation of mTOR can be confirmed, but generally 1 μg / g to 200 mg / g (the denominator indicates the weight of the preparation). ) Range. The range is preferably 10 μg / g to 20 mg / g, and most preferably 100 μg / g to 10 mg / g.

  The dosage form of the preparation constituted in the present invention is not particularly limited as long as it can be administered orally or parenterally. Capsule, powder, granule, solid, liquid, gel, foam, emulsion Forms, creams, ointments, sheets, mousses, powder dispersions, multilayers, aerosols, and the like. Preferably, it is a dosage form having an external form optimal for application to the human skin. Examples of forms for external use include, for example, lotions represented by cosmetics and quasi-drugs (including whitening and anti-aging), emulsions (including whitening and anti-aging), and creams (whitening and anti-aging). ), Lotions (including whitening and anti-aging), packs (including whitening and anti-aging), soaps and body shampoos, facial cleansers, lipsticks and foundations. Moreover, ointments and patches, lotions, poultices, liniments and the like typified by pharmaceuticals and quasi drugs are listed.

  In addition to the above-mentioned compounds that are essential active ingredients, the preparations of the present invention can be further added with various functions by arbitrarily selecting and using various components exemplified below as additives. Is possible. Although content in a formulation is not specifically limited, Usually, the density | concentration range of 0.0001 to 50 weight% is common.

Pigmentation inhibitor A pigmentation inhibitor can be added to the preparation of the present invention. Specific examples of pigmentation inhibitors include p-aminobenzoic acid derivatives, salicylic acid derivatives, benzenesulfonamide derivatives, imidazole derivatives, naphthalene derivatives, hydroxyanthranilic acid or salts thereof, and derivatives thereof, anthranilic acid derivatives, coumarin derivatives, amino acids Derivatives (2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid, 2-amino-3- [1-carboxyl-2- (1H-imidazole) -4-yl) ethyl] aminobutanoic acid hydrochloride, 2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid sodium salt, 2-amino-3- [ 1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid potassium salt, etc.), benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor Derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, ascorbic acid or salts thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyprosthelic acid) Phosphorus phosphate, 5-o-α-D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L -Ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbine Acid sulfate ester calcium salt, L-ascorbate sulfate aluminum salt, L-ascorbate sodium salt, L-ascorbate potassium salt, L-ascorbate magnesium salt, L-ascorbate calcium salt, L-ascorbate aluminum salt, 6-o-α-D-galactopyranosyl-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid Phosphate sodium salt, L-ascorbic acid sulfate sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphoric acid Ester isopropanolamine salt, 3-o-isopropyl-L-ascorbic acid, 6-o-alkylascorbic acid phosphate Tellurium salt, 6-o-alkylascorbic acid phosphate calcium salt, 6-o-alkylascorbic acid phosphate barium salt, 6-o-alkylascorbic acid phosphate ammonium salt, 6-o-alkylascorbic acid Phosphate monoethanolamine salt, 6-o-alkylascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt 6-o-alkylascorbic acid phosphate diisopropanolamine salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D- Galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate cholesterol Ester, palmitic acid-L-ascorbyl, isopalmitic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid -L-ascorbyl, diisostearic acid-L-ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid- L-ascorbyl, di-2-ethylhexanoic acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L -Ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid , 2-o-α-D- Lutotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitate, L-ascorbic acid tetralaurate, L-ascorbate tetra-2-ethylhexanoate, L-ascorbate tetraoleate, 5, 6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbine Acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl cinna Pate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxyferrate, DL-α- Coferol-2-L-ascorbic acid phosphoric diester, ascorbic acid inositol binding derivative, ascorbic acid phosphoramide derivative, ascorbyl arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative, etc.), tocopherol or its Salts and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol Acetate, tocopherol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucosi DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl Glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-toco Ferryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β- Tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- ( Sulfoethylamino) -3- (α-toco Eleyl-6-Iroxy) propan-2-ol, 1- (Carboxypropylamino) -3- (α-tocopheryl-6-Iroxy) propan-2-ol hydrochloride, S- [3- (α-Toco Ferroyl-6-iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof And derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol Orotate), kojic acid or its derivatives (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoyloxymethyl-5 -Hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one, kojic acid Glucose, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate , Kojic acid dioleate, etc.), oxybenzone, benzophenone, guaiazulene, shikonin, baicalin or a salt thereof and derivatives thereof Baicalein or a salt thereof and derivatives thereof, berberine or a salt thereof and derivatives thereof, chrysin or a salt thereof and derivatives thereof, apigenin or a salt thereof and derivatives thereof, luteolin or a salt thereof and derivatives thereof, acetetine or a salt thereof and Derivatives thereof, diosmethine or a salt thereof and derivatives thereof, kaempferol or a salt thereof and derivatives thereof, triphorin or a salt thereof and derivatives thereof, astragalin or a salt thereof and derivatives thereof, quercetin or a salt thereof and derivatives thereof Quercitrin or a salt thereof and derivatives thereof, isoquercitrin or a salt thereof and derivatives thereof, rutin or a salt thereof and derivatives thereof, morin or a salt thereof and derivatives thereof, myricetin or a salt thereof And derivatives thereof, myristitrin or a salt thereof and derivatives thereof, dachiscetin or a salt thereof and derivatives thereof, quercetagetin or a salt thereof and derivatives thereof, isorhamnetin or a salt thereof and derivatives thereof, pinocembrin or a salt thereof and derivatives thereof Naringenin or a salt thereof and derivatives thereof, hesperetin or a salt thereof and derivatives thereof, eriodictyol or a salt thereof and derivatives thereof, pinobankin or a salt thereof and derivatives thereof, aromadendrin or a salt thereof and derivatives thereof, Engeritin or a salt thereof and derivatives thereof, taxofolin or a salt thereof and derivatives thereof, astilbine or a salt thereof and derivatives thereof, amperopsin or a salt thereof and derivatives thereof, Spira Oside, kaempferol-7-neohesperidoside, glutathione or salts thereof and derivatives thereof, isoflavone glycosides (6-o-apiosyl puerarin-4'-o-glucoside, 6-o-glucosyl puerarin, 3 '-Hydroxypuerarin-4'-o-glucoside,6-o-apiosyl-3'-hydroxypuerarin, etc.), γ-pyrone glycoside (maltol-3-o- (6'-o-apiosyl) -glucoside, maltol -3-o- (6′-o-apiosyl) -glucoside etc.), isononyl ferrate, ellagic acid or its salts and derivatives thereof (5,4-dimethylellagic acid, 3,3′-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-methoxyellagic acid, 3-ethyl-4-methyl-5-hydroxyellagic acid, amritoside, etc.), lucinol, Onji Saponin, Bacmond Saponin, Ruscogenin, Celicoside, Asian Chicoside Hederin, senegin, benzoic acid anilides (4-hydroxy-N- (2-hydroxyphenyl) benzoic acid amide, 4-hydroxy-N- (3-hydroxyphenyl) benzamide, 4-hydroxy-N- (4-hydroxyphenyl) ) Benzamide, 3,5-di-t-butyl-4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N- (3-hydroxyphenyl) benzamide , 3,5-di-t-butyl-4-hydroxy-N- (2-hydroxyphenyl) benzamide, etc.), diphenylpyralin, cyproheptadine, triprolysine, dimethindene, ozagrel, istipendyl, iproheptin, homochlorcyclidine, alimemazine, Bucillamine, oxytosamide, vidarabine, xanthotoxol, phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide, fetus (Bovine-derived, porcine-derived, horse-derived, sheep-derived, etc.) extract, almond extract, amaranth extract, octopus extract, lobster extract, okera extract, kofuyou extract, uncaria extract, gaija extract, kako Juyou Extract, Licorice Extract, Gardenia Extract, Kranigean Extract, Clara Extract, Koganebana (Ogon) Extract, Wheat (Wheat) Extract, Rice (Rice) Extract, Korealia Extract, Sidwaya Extract, Sunku Kyu Extract, San Vitro Extract, Sunpens extract, Silane (Biacaria) extract, Senkyu (river cucumber) extract, Senna extract, Sempukuka extract, Sentsutsusai extract, Surigatin extract, Nodake (former cucumber) extract, pearl barley (Yokuinin) extract, Vulture extract, Honey beetle , Hamamelis extract, palm extract, parietalia extract, safflower (safflower) extract, mugwa (mulberry white skin) extract, malvanojadine (bitter) extract, purple squirrel extract, white squirrel extract, mugwort extract, yashajitsu extract, hongkong Examples include an extract, a bitter melon extract, a quail extract, a citrus extract, and a millipede extract.

Tyrosinase activity inhibitor A tyrosinase activity inhibitor can be added to the preparation of the present invention. Specific examples of tyrosinase activity inhibitors include ascorbic acid or salts thereof and derivatives thereof (magnesium phosphate-L-ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyprophosphate phosphate ascorbate, 5-o-α -D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid Sulfate Stell aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyrano Sil-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Ester sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl- L-ascorbic acid, 6-o-alkylascorbic acid potassium ester potassium salt, 6-o-alkylascorbic acid phosphate Steal calcium salt, 6-o-alkyl ascorbic acid phosphate barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o-alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl Ascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanol Amine salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, phosphorus ascorbate Acid cholesterol ester, palmitic acid-L-ascorbyl, isopa Mycinic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid-L-ascorbyl, diisostearic acid-L- Ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid-L-ascorbyl, di-2-ethylhexane Acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α- D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-malto Triosyl-L-ascorbic acid, L-ascorbic acid Trisopalmitic acid ester, L-ascorbic acid tetralauric acid ester, L-ascorbic acid tetra-2-ethylhexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, L- Ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbyl triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl cinnamate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphoric acid diester, Scorbic acid inositol binding derivative, ascorbic acid phosphoramide derivative, ascorbic acid arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative, etc.), hydroquinone or its salts and derivatives thereof (hydroquinone α-D-glucose , Hydroquinone β-D-glucose, hydroquinone α-L-glucose, hydroquinone β-L-glucose, hydroquinone α-D-galactose, hydroquinone β-D-galactose, hydroquinone α-L-galactose, hydroquinone β-L-galactose, etc. Hexoses, hydroquinone α-D-ribose, hydroquinone β-D-ribose, hydroquinone α-L-ribose, hydroquinone β-L-ribose, hydroquinone α-D-arabinose, hydroquinone β-D-a Five carbon sugar glycosides such as rabinose, hydroquinone α-L-arabinose, hydroquinone β-L-arabinose, hydroquinone α-D-glucosamine, hydroquinone β-D-glucosamine, hydroquinone α-L-glucosamine, hydroquinone β-L- Amino sugar glycosides such as glucosamine, hydroquinone α-D-galactosamine, hydroquinone β-D-galactosamine, hydroquinone α-L-galactosamine, hydroquinone β-L-galactosamine, hydroquinone α-D-glucuronic acid, hydroquinone β-D- Glucuronic acid, hydroquinone α-L-glucuronic acid, hydroquinone β-L-glucuronic acid, hydroquinone α-D-galacturonic acid, hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, hydroquinone β-L-galacturonic acid Hydroquinone glycosides such as uronic acid glycosides Hydroquinone benzyl ether, 4-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) butane, 5-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) pentane, 6- β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) hexane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propane, 2-β-D-glucopyra Hydroquinone hydroxyalkyl ether glycosides such as nosyloxy-1- (4-hydroxyphenoxy) butane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propan-3-ol, etc.) Kojic acid or a salt thereof and derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoyloxymethyl- 5-Hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hy Droxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate , Kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.), tocopherol or a salt thereof and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate Tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ- Tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β -Tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L- α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ- Coferyl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, L- (sulfoethylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol, 1 -(Carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] Cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2 -Hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate , Tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate, etc.), N-acetyltyrosine or a salt thereof and derivatives thereof, glutathione or a salt thereof and derivatives thereof, ellagic acid or a salt thereof and derivatives thereof (3,4-dimethylellagic acid, 3,3'-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-methoxyellagic acid, 3- Ethyl-4-methyl-5-hydroxyellagic acid, amritosides, etc.), isonitrine A, isonitrine B, isonitrine C, isonitrin D, isonitrinic acid E, isonitrinic acid F, dermadein, tricobylidein and other isonitrile antibiotics, orthoric acid derivatives (Orceric acid, orceric acid ethyl ester orcinol, p-geranylorceric acid, p-gerani Orceric acid ethyl ester geranyl orcinol, p-farnesylorceric acid, p-farnesylorceric acid ethyl ester farnesylorcinol, p-dodecanylorceric acid, p-dodecanylorceric acid ethylester dodecanylorcinol, p -Tetradecanylorceric acid, p-tetradecanylorceric acid ethyl ester tetradecanylorcinol, p-hexadecanylorceric acid, p-hexadecanylorceric acid ethylester hexadecanylorcinol, p -Undecanylorceric acid, p-undecanylorceric acid ethyl ester undecanylorcinol, p-tridecanylorceric acid, p-tridecanylorceric acid ethylester undecanylorcinol, p-penta Decanylorceric acid, p-pentadecanylorserine Ethyl ester pentadecanylorcinol, ethylhexylorceric acid, p-ethylhexylorceric acid ethylester ethylhexylorcinol, p-cyclohexylmethylorceric acid, p-cyclohexylmethylorceric acid ethylester cyclohexylmethylorcinol, p-hydroxy Ethyl hexylorceric acid methyl ester, p-hydroxyethylhexylorceric acid hydroxyethylhexylorcinol, etc.), umbelic acid, brefeldin, oxydesveratrol, resorcinol derivative (4-cyclohexylresorcinol), 3-hydroxyketone compound (1, 5-bis (p-hydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (o, p-dihydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (p- Hydroxyphenyl-m-meth Ciphenyl) -2-hydroxypentan-4-one), 1,3-diketone compounds (1,5-bis (p-hydroxyphenyl) -2,4-pentanedione, 1,5-bis (o, p- Dihydroxyphenyl) -2,4-pentanedione, 1,5-bis (p-hydroxyphenyl-m-methoxyphenyl) -2,4-pentanedione, etc.), bishydroxybenzylamides, γ-aminobutyric acid or derivatives thereof (N-methyl-γ-aminobutyric acid, N-dimethyl-γ-aminobutyric acid, γ-aminobutyric acid oleyl ester, etc.), hydrogen peroxide, zinc peroxide, placenta extract, lucinol, silk extract, acacia extract, acerola extract, Ichibi (winter position) extract, Weeping birch extract, Quercus extract, Chestnut extract, Tortoise extract, Tobacco extract, Tobacco extract, Seri extract, Buckwheat extract, Davilia extract, Nazuna extract, F Zibakama (Orchid) extract, Chamomile extract, Mulberry extract, Gardenia extract, Japanese cypress extract, Walnut extract, Clara extract, Mugwort extract, Honeysuckle extract, Yellowfin extract, Dokudami extract, Matsuhodo extract, Pearl barley extract, Odorikosou extract, Hop extract, Hawthorn extract, Eucalyptus Extract, Achillea millefolium extract, Altea extract, Keihi extract, Mantis extract, Hamamelis extract, Yamaguchi extract, bellflower extract, Toshishi extract, Zyoko extract, Shoot dried extract, Mao extract, Senkyu extract, Dokatsu extract, Psycho extract, Bow extract, Hamaboufu Extract, Ogon extract, Peony skin extract, Peonies extract, Gennoshoco extract, Kudzu root extract, Licorice extract, Pyramid extract, Aloe extract, Shouma extract Safflower extract, green tea extract, black tea extract, include Uncaria gambir Roxburgh extract, and the like.

Melanocyte Melanin Production Inhibitor A melanocyte melanin production inhibitor can be added to the preparation of the present invention. Specific examples of melanocyte melanin production inhibitors include lobeline or lobeline derivatives, liquiritin derivatives (such as liquiritin-α-glucoside, liquiritin-α-maltoside), phenylchroman derivatives, chromone derivatives (2-butylchromone, 2-pentylchromone, 2 -Heptylchromone, 2-nonylchromone, 2-hexadecylchromone, 2- (1-ethylpentyl) chromone, 2-butyl-7-methoxychromone, 2-pentyl-7-methoxychromone, 2-heptyl-7-methoxychromone 2-nonyl-7-methoxychromone, 2-pentadecyl-7-methoxychromone, 2- (1-ethylpentyl) -7-methoxychromone, 7-hydroxy-2-methylchromone, 7-hydroxy-2-butylchromone 7-hydroxy-2-pentylchromone, 7-hydroxy-2-heptylchromone, 7-hydroxy-2-nonylchromone, 7-hydroxy-2-penta Desylchromone, 7-hydroxy-2- (1-ethylpentyl) chromone), azelaic acid derivatives (azelaic acid monoalkyl ester, azelaic acid dialkyl ester, etc.), phosphatidylglucosamine, lysophosphatidylglucosamine, phenylhydroquinone, 3-β-D -Glucopyranosyl manur, 3-β-D-maltopyranosyl manur, substituted amino acid derivatives (DL-N-formyl-3- (1-naphthyl) alanine, DL-N-acetyl-3- (1-naphthyl) ) Alanine, DL-N-propionyl-3- (1-naphthyl) alanine, DL-N-butyryl-3- (1-naphthyl) alanine, DL-N-isobutyryl-3- (1-naphthyl) alanine, DL- N-valeryl-3- (1-naphthyl) alanine, DL-N-isovaleryl-3- (1-naphthyl) alanine, DL-N- (2-methylvaleryl) -3- (1-naphthyl) alanine, DL-N -(3-Methylvaleryl) -3- (1-naphthyl) alanine, DL-N- (4-Methylvaleryl) -3- (1 -Naphthyl) alanine, DL-N-t-butylacetyl-3- (1-naphthyl) alanine, DL-N-pivaloyl-3- (1-naphthyl) alanine, DL-N-caproyl-3- (1-naphthyl) ) Alanine, DL-N- (2-ethylhexanoyl) -3- (1-naphthyl) alanine, DL-N- (2-methylhexanoyl) -3- (1-naphthyl) alanine, DL-N-heptanoyl -3- (1-naphthyl) alanine, DL-N-octanoyl-3- (1-naphthyl) alanine, DL-N- (2-propylpentanoyl) -3- (1-naphthyl) alanine, DL-N- Nonanoyl-3- (1-naphthyl) alanine, DL-N-decanoyl-3- (1-naphthyl) alanine, DL-N-undecanoyl-3- (1-naphthyl) alanine, DL-N-dodecanoyl-3- ( 1-naphthyl) alanine, DL-N-tridecanoyl-3- (1-naphthyl) alanine, DL-N-tetradecanoyl-3- (1-naphthyl) alanine, DL-N-pentadecanoyl-3- (1 -Naphthyl) alanine, DL-N-hexadecanoyl-3- (1-naphthyl) alanine DL-N-heptadecanoyl-3- (1-naphthyl) alanine, DL-N-octadecanoyl-3- (1-naphthyl) alanine, DL-N-nonadecanoyl-DL-3- (1-naphthyl) alanine, DL -N-icosanoyl-3- (1-naphthyl) alanine, DL-N-acryloyl-3- (1-naphthyl) alanine, DL-N-crotoniloyl-3- (1-naphthyl) alanine, DL-N-methacryloyl- 3- (1-naphthyl) alanine, DL-N-vinylacetyl-3- (1-naphthyl) alanine, DL-N-cyclopropanoyl-3- (1-naphthyl) alanine, DL-N- (2-pentenoyl ) -3- (1-naphthyl) alanine, DL-N- (4-pentenoyl) -3- (1-naphthyl) alanine, DL-N- (2-hexenoyl) -3- (1-naphthyl) alanine, DL -N- (3-hexenoyl) -3- (1-naphthyl) alanine, DL-N- (2-methyl-3-pentenoyl) -3- (1-naphthyl) alanine, DL-N-cyclohexenoyl -3- (1-naphthyl) alanine, DL-N- (10-undecenoyl) -3- (1-naphthyl) alanine, D LN-linoleyl-3- (1-naphthyl) alanine, DL-N-hydroxyacetyl-3- (1-naphthyl) alanine, DL-N- (6-hydroxycaproyl) -3- (1-naphthyl) alanine, DL-N- (8-hydroxyoctanoyl) -3- (1-naphthyl) alanine, DL-N- (9-hydroxynonanoyl) -3- (1-naphthyl) alanine, DL-N- (10-hydroxy Decanoyl) -3- (1-naphthyl) alanine, DL-N- (11-hydroxyundecanoyl) -3- (1-naphthyl) alanine, DL-N- (12-hydroxydecanoyl) -3- ( 1-naphthyl) alanine, DL-N-benzoyl-3- (1-naphthyl) alanine, DL-N- (2-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-hydroxybenzoyl ) -3- (1-naphthyl) alanine, DL-N- (4-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (o-toluyl) -3- (1-naphthyl) alanine, DL-N- (m-Toluyl) -3- (1-naphthyl) alanine, DL-N- (p-Toluyl) -3- (1-naphthyl) ara DL-N- (1-naphthyl) -3- (1-naphthyl) alanine, DL-N- (2-naphthyl) -3- (1-naphthyl) alanine, DL-N- (2-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (4-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (2-picoline) -3- (1-naphthyl) alanine, DL-N- (3-picoline) -3- (1-naphthyl) alanine, DL-N- (4-picoline) -3- (1-naphthyl) alanine, DL-N-phenylacetyl-3- (1-naphthyl) alanine, DL-N- (2-phenylpropanoyl) -3- (1-naphthyl) alanine, DL-N- (3 -Phenylbutyryl) -3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine, DL-N-valeryl-3- (1-naphthyl) alanine, DL -N- (4-methylvaleryl) -3- (1-naphthyl) alaninamide, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine methyl ester DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine ethyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine propyl ester, DL-N- (4-methylvaleryl ) -3- (1-naphthyl) alanine-N-butyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine pentyl ester, DL-N- (4-methylvaleryl) -3- ( 1-naphthyl) alanine isopropyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine isobutyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine-t- Butyl ester, etc.), benzolactam derivatives, indolactam derivatives, cedrol, guaiool, 1- (4-hydroxyphenthio) -2-propanol, β-lactoglobulin, 2-methoxy-5-methylphenol, 5-ethyl-2 -Methoxyphenol, 5-N-propyl-2-methoxyphenol, 5-N-butyl-2-methoxypheno 5-N-hexyl-2-methoxyphenol, 5-N-heptyl-2-methoxyphenol, 5-N-decyl-2-methoxyphenol, 5- (1,1-dimethylpropyl) -2-methoxy Phenol, 5- (1,1-dimethylbutyl) -2-methoxyphenol, 5- (1,1-dimethylethyl) -2-methoxyphenol, 2-methoxy-5- (1-methylpentyl) phenol, 2- Methoxy-5- (1-methylhexyl) phenol, 2-methoxy-5- (3-methylhexyl) phenol, 2-methoxy-5- (6-methylheptyl) phenol, 5- (1,3-dimethylheptyl) -2-Methoxyphenol, malvelin, ferguinol, sugiol, cryptojaponol, 1,5-bis [p-hydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [o-hydroxyphenyl]- 1,4-pentadien-3-one, 1,5-bis [2,4-dihydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [3-mes Xyl-4-hydroxyphenyl] -1,4-pentadien-3-one, haginin, agrimophor, agrimol, hydrangenol or derivatives thereof, alkylresorcinol or derivatives thereof (such as 4-N-butylresorcinol), aristrone, Caramenenes (such as caramenene, 7-hydroxycaramenene, 5-hydroxycaramenene, 7-methoxycaramenene), trans-umberic acid, N-α-benzoyl-L-arginine, N-α-benzoyl-L-arginine ethyl Ester or N-α-benzoyl-L-arginine ethyl ester, 5-methyl-2 (3H) -furanone, 2-butene-4-olide, 2-hydroxymethylfuran, 2,5-dimethyl-4-hydroxy-3 (2H) -furanone, 2-formylfuran, 3-formylfuran, methyl α-furyl ketone, furfuryl acetate, 2-hydroxy-3-methyl-2-cyclopenten-1-one, 2-hydroxy-3,5 -Dimethyl-2-cyclopenten-1-one, 2,5-dimethyl-4-hydroxy-3 (2H) -thiophenone, 2-hydroxy-3-ethyl-2-cyclopenten-1-one, tetronic acid, pentanedione, Iminodibenzyls (2,2'-iminodibenzyl, imipramine, imipramine hydrochloride, desipramine, desipramine hydrochloride, chlorimipramine, trimipramine, etc.), dibenzocycloheptadienes (amitriptyline, amitriptyline hydrochloride, nortriptyline, noxiptylline, etc.), Tetrahydrocopalol glycosides (ketotifen fumarate, labda-8 (17), 13-dien-15-ol, tetrahydromanur, tetrahydrocoparol, tetrahydrocoparol glucoside, tetrahydrocoparol galactoside, tetrahydrocoparol maltoside, Tetrahydrocoparol cellobioside, Tet Lahydrocopalol maltotrioside, etc.), spiro ether compound, piochelin, phenothiazine compound, promethazine, alimemazine, alimemazine tartrate, triflupromazine, levomepromazine, chlorpromazine, cyclandrate, 4-carboxymethyloxybenzoic acid, 4-carboxymethyl Oxy-2-hydroxybenzoic acid, 3- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) benzoic acid, 4- (3-carboxypropyl- 1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-methoxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4 -(5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1 -Oxy) -2-hydroxybenzoic acid, 4- (10-carbamoyldecane-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) benzoic acid, 4- (4-hydroxy Butyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-acetoxybutyl-1-oxy) benzoic acid, 4- (4-acetoxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- ( 3-Ethoxycarbonylpropyl-1-oxy) -2-hydroxybenzoic acid, 3- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-methoxybutyl-1-oxy) 2-hydroxybenzoic acid, 4- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3- (3-carboxypropyl-1- Oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxy Benzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1 -Oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid, hydroxytrimethylcyclohexanes (2-hydroxy-4- (2,2,6-trimethyl-1) -Yl-cyclohexane) butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -1-butene, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2-butene 4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 3-methyl-3-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl -1-Hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl -1-Hydro Ci-5- (2,2,6-trimethyl-1-yl-cyclohexane) -3-pentene, 3-methyl-3-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane)- 1-pentene, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -2-pentene, 2-hydroxy-4- (2,2,6-trimethyl-1 -Mono-, di- or trisaccharide glycosides such as -yl-cyclohexane) butane), escinol, parahydroxycinnamic acid-4- (2,2,6-trimethyl-yl-cyclohexane) -2-butyl ester Monosaccharide, disaccharide or trisaccharide glycoside, ondisaponin, bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin, senegin, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2 -Keto-butane, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto-butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2 -Keto-3-butene, 4- (2,2 , 6-trimethyl-1-yl-6-cyclohexene) -2-keto-3-butene (β-ionone), Lp-hydroxyphenylglycine,
Dp-hydroxyphenylglycine, N-benzyloxycarbonyl-Lp-hydroxyphenylglycine, N-benzyloxycarbonyl-Dp-hydroxyphenylglycine, N-benzoyl-Lp-hydroxyphenylglycine, N-benzoyl-Dp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Dp-hydroxyphenylglycine, N- (p-hydroxybenzoyl) -Lp-hydroxyphenylglycine, N- (p- Hydroxybenzoyl) -Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine, N-acetyl-Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine ethyl ester, N-acetyl-Dp-hydroxyphenyl Glycine ethyl ester, N-acetyl-Lp-hydroxyphenylglycine Amide, N-acetyl-Dp-hydroxyphenylglycine amide, Lp-methoxyphenylglycine, Dp-methoxyphenylglycine, Lp-methoxyphenylglycine hydrochloride, Dp-methoxyphenylglycine hydrochloride, 4-hydroxy-3-methoxy-L -Phenylglycine, 4-hydroxy-3-methoxy-D-phenylglycine, Lp-hydroxyphenylglycine ethylamide, Dp-hydroxyphenylglycine ethylamide, N-tert-butoxycarbonyl-Lp-hydroxyphenylglycine, N-tert- Butoxycarbonyl-Dp-hydroxyphenylglycine, N-tert-butoxycarbonyl-Lp-methoxyphenylglycine, N-tert-butoxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxyphenyl Glycine, N-9-fluorenylmethyloxycarbonyl-Dp-methoxy Phenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxyphenylglycine benzyl ester hydrochloride, N-9-fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine benzyl ester hydrochloride, Lp-hydroxyphenylglycine Amide, Dp-hydroxyphenylglycine amide, Lp-hydroxyphenylglycine allyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine allyl ester p-toluenesulfonate, Lp-hydroxyphenylglycine benzyl ester p-toluenesulfonate , Dp-hydroxyphenylglycine benzyl ester p-toluenesulfonate, Lp-hydroxyphenylglycine ethyl ester, Dp-hydroxyphenylglycine ethyl ester, Lp-hydroxyphenylglycine ethyl ester hydrochloric acid , Dp-hydroxyphenylglycine ethyl ester hydrochloride, Lp-hydroxyphenylglycine methyl ester, Dp-hydroxyphenylglycine methyl ester, etc., 1,3-diallylindane-2-carboxylic acids, stachybocins, pheophorbide derivatives, eleucerin, isoeleucerine or 4-β-hydroxyisoeleucerin, eleucerinol, spiroketal derivative (2- (2,4-hexadiniylidene) -1,6-dioxaspiro [4.5] dec-3-ene, 2- (2-hexynylidene)- 1,6-dioxaspiro [4.4] nona-3-ene, 2-((4-methylphenyl) methylidene) -6,6-dioxaspiro [4.4] non-3-ene, 2- (2-hexenylidene) -6, 6-dioxaspiro [4.5] dec-3-ene, 2- (2-hexenylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-hexyl-1,6-dioxaspiro [4.4] nonane, 2- (2-Hexenyl) -1,6-dioxaspiro [4.4] no , 2- (2-hexynyl) -1,6-dioxaspiro [4.4] nonane, 2-pentyl-1,6-dioxaspiro [4.4] nonane, 1,6-dioxaspiro [4.4] nonane, 1,6-dioxaspiro [ 4.5] decane, 1,7-dioxaspiro [5.5] undecane, 2,3-benzo-4,4-dimethyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-pentyl-1,6- Dioxaspiro [4.4] nonane, 3,4-benzo-2-hexyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-octyl-1,6-dioxaspiro [4.4] nonane, 2-hexyl- 9,9-dimethyl-1,6-dioxaspiro [4.4] nonane, 2- (2,4-hexadiniylidene) -1,6-dioxaspiro [4.4] non-3-ene), malvalic acid, phosphonic acid derivatives Or a salt thereof, aspergillomarasmin, an aminophosphonic acid derivative or salt thereof, diphenhydramine or a salt thereof, pregnenolone or a derivative thereof, lutein, farnesyl isopropano Derivatives, hexahydrofarnesyl acetone, 4-benzoylamino-2-hydroxybenzoic acid, 5-benzoylamino-2-hydroxybenzoic acid, 4-benzoylaminobenzoic acid, 4- (1-naphthoylamino) -2- Hydroxybenzoic acid, 5- (1-naphthoylamino) -2-hydroxybenzoic acid, 4- (2-naphthoylamino) -2-hydroxybenzoic acid, 5- (2-naphthoylamino) -2-hydroxybenzoic acid Acid, 4- (1-naphthoylamino) benzoic acid, 4- (2-naphthoylamino) benzoic acid, 4-phenylaminocarbonylbenzoic acid, 4-phenylaminocarbonyl-2-hydroxybenzoic acid, 5-phenylamino Carbonyl-2-hydroxybenzoic acid, 4- (1-naphthylaminocarbonyl) benzoic acid, 4- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid Acid, 4- (2-naphthylamino Rubonyl) benzoic acid, 4- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, hexahydrofarnesyl isopropanol derivative, borneol-p-hydroxycinnamic Acid ester glucoside, borneol-p-hydroxycinnamic acid maltoside, borneol-p-hydroxycinnamic acid maltotrioside, cinnamic acid-4- (2,2,6-trimethyl-yl-cyclohexane) -2- Butyl ester derivatives, 2,4-dihydroxybenzophenone, 1- (2,4-dihydroxyphenyl) -ethanone (2 ', 4'-dihydroxyacetophenone), 1- (2,4-dihydroxyphenyl) -1-propanone (2 ', 4'-dihydroxypropiophenone), 1- (2,4-dihydroxyphenyl) -1-butanone, 1- (2,4-dihydroxyphenyl) -1-pentanone, 1- (2,4-dihydroxyphenone) ) -1-Hexanone, 1- (2,4-dihydroxyphenyl) -1-heptanone, 1- (2,4-dihydroxyphenyl) -1-octanone, 1- (2,4-dihydroxyphenyl) -1-nonanone 1- (2,4-dihydroxyphenyl) -1-decanone, 1- (2,4-dihydroxyphenyl) -1-undecanone, 1- (2,4-dihydroxyphenyl) -1-dodecanone, 1- (2 , 4-dihydroxyphenyl) -1-tetradecanone, 1- (2,4-dihydroxyphenyl) -1-hexadecanone, 1- (2,4-dihydroxyphenyl) -1-octadecanone, 1- (2-hydroxy-4- Methoxyphenyl) -ethanone (2′-hydroxy-4′-methoxyacetophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-propanone (2′-hydroxy-4′-methoxypropiophenone), 1 -(2-hydroxy-4-methoxyphenyl) -1-butanone, 1- (2-hydroxy-4-methoxyphenyl) -1-pentanone, 1- (2-hydroxy-4-methoxypheny ) -1-Hexanone, 1- (2-hydroxy-4-methoxyphenyl) -1-heptanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octanone, 1- (2-hydroxy-4-methoxy) Phenyl) -1-nonanone, 1- (2-hydroxy-4-methoxyphenyl) -1-decanone, 1- (2-hydroxy-4-methoxyphenyl) -1-undecanone, 1- (2-hydroxy-4- Methoxyphenyl) -1-dodecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-tetradecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-hexadecanone, 1- (2-hydroxy-4 -Methoxyphenyl) -1-octadecanone, 1- (4-hydroxy-2-methoxyphenyl) -ethanone (4'-hydroxy-2'-methoxyacetophenone), 1- (4-hydroxy-2-methoxyphenyl) -1 -Propanone (4'-hydroxy-2'-methoxypropiophenone), 1- (2,4-dimethoxyphenyl) -ethanone (2 ', 4'-dimethoxyacetopheno) ), 1- (2,4-dimethoxyphenyl) -1-propanone (2 ′, 4′-dimethoxypropiophenone), lactone derivatives (1,6-dioxaspiro [4.4] nonane-2,7-dione, 1, 6-dioxaspiro [4.5] decane-2,7-dione, 4-tridecanolide, 4-dodecanolide, 4-undecanolide, 4-decanolide, 4-nonanolide, 4-octanolide, 4-heptanolide, 5-dodecanolide, 5-undecanolide, 5-decanolide, 5-nonanolide, 5-octanolide, 2-undecen-4-olide, 2-decen-4-olide, 2-nonen-4-olide, 2-heptene-4-olide, 2-undecen-5- Orido, 2-Decene-5-Olide, 2-Nonene-5-Olide, 2-Octene-5-Olide, 4-Methyl-4-dodecanolide, 4-Methyl-4-undecanolide, 4-Methyl-4-decanolide, 4-methyl-4-nonanolide, 4-methyl-4-heptanolide, 5-methyl-5-dodecanolide, 5-methyl-5-undecanolide, 5-methyl-5- Decanolide, 5-methyl-5-nonanolide, 5-methyl-5-octanolide, 2-methoxycarbonyl-4-dodecanolide, 2-methoxycarbonyl-4-undecanolide, 2-methoxycarbonyl-4-decanolide, 2-methoxycarbonyl- 4-nonanolide, 2-methoxycarbonyl-4-heptanolide, 2-methoxycarbonyl-5-undecanolide, 2-methoxycarbonyl-5-decanolide, 2-methoxycarbonyl-5-nonanolide, 2-methoxycarbonyl-5-octanolide, 2 -Allyl-4-undecanolide, 2-allyl-5-decanolide, 2-allyl-4-nonanolide, 2-pentyl-4-undecanolide, 2-pentyl-4-nonanolide, 2-methyl-4-undecanolide, 2-methyl -4-nonanolide, 2- (4-hydroxybutyl) -4-undecanolide, 2- (4-hydroxybutyl) -4-nonanolide, 2- (4-hydroxybutyl) -5-decanolide, 5-propyloxy-4 -Penta Lido, 5-allyloxy-4-pentanolide, 5- (2-hydroxyethoxy) -4-pentanolide, 8-hydroxy-4-octanolide, 6-propyloxy-5-hexanolide, 6-allyloxy-5-hexanolide, 6- (2-hydroxyethoxy) -5-hexanolide, 9-hydroxy-5-nonanolide, etc.), ethinomycin, iriflorental, iriparidal, 2'-8-C-glucosyl-7-methylaloesol coumaroyl ester, 2 ' -8-C-Glucosyl-7-methylaloesol cinnamoyl ester, chloropyramine, anise extract, aloe extract, itadori (tiger cane root) extract, seaweed extract, shrimp extract, ketsumeishi extract, ogi (yellow tuna) extract , Yellow sprout extract, giant beetle extract, red fir tree extract, onion yaga extract, oyster extract, giant redbird extract, Yak Extract, Pumpkin Extract, Gama (Amber Yellow) Extract, Kansui Extract (Sweet Crab) Extract, Buttercup (Sentsukakusa) Extract, Chromoji Extract, Black Spider Extract, Sisal (Sisal Asa) Extract, Saxima Button Kale Extract, Cinnamon Peel Extract, Cinnamon Ginseng (Wei Sensen) extract, Oshima cherry extract, Oya cherry extract, bean cherry extract, Takane cherry extract, Kohigan extract, Sato cherry extract, Zion extract Extract, Dimonda extract, Primrose extract, Toshishi extract, Legume extract, Prunus extract, Buttercup extract, Yarrow extract, Duck extract, Dill extract, Honey beetle extract, Bamboo extract Hitotsuba (stone persimmon) extract, Himegama (koi) extract, peony extract, floral blanca extract, hamula extract, sagebrush extract, convolvulus extract, sandalwood extract, ganoderma biloba extract, swordfish (benthic grass extract), kawayanagi extract, akame willow Extract, Pussy Willow Extract, Inco Collagen Willow Extract, Kinu Willow Extract, Corry Willow Extract, Unryu Willow Extract, Miya Willow Extract, Willow Willow Extract, Obayan Willow Extract, Tairikinu Willow Extract, Fox Willow Extract, Dronoki Extract, Wild Plum Extract Agave extract, Aonus agave extract, Fukurin agave extract, Mitsumata extract, Aonori extract, Usba aonori extract, Sugia aonori extract, Hira aonori extract, Huaonori Extract, Hosoeda Aonori Extract, Kombu Extract, Macombu Extract, Resilicone Extract, Hosome Kombu Extract, Mitsuishi Kombu Extract, Wakame Extract, Hirome Extract, Blue Mosquito Extract, Hijiki Extract, Hibamata Extract, Umichiwa Extract, Usubau Miuchiwa Extract, Kirebano Miyu Extract Extract , Suginori Extract, Shikinori Extract, Kainori Extract, Yakuzusa Extract, Ulaboshiya Extract, Umichiwa Extract Extract Extract, Yolemoku Extract, Sawtooth Moku Extract, Psyllium Shrimp Extract, Centipede Extract, Nurakusa Extract, Cronouraxa Extract, Streptomyces Extract, Pine Tree Extract, Prunus Extract Black Sozo Extract, Cobsozo Extract, Honey Sozo Extract, Sozo no Hana Extract, Hazel Sawtooth Extract, Thira Extract, Camote de Azafuran Kiss, Hamaikaekisu, port Leo Verde extract, Nabo Negro extract, Schisandra chinensis extract, Matsubusa extract, Binankazura extract, and the like.

Melanin production promoter A melanin production promoter can be added to the preparation of the present invention. Specific examples of the melanin production accelerator include salicylic acid or a salt thereof and derivatives thereof (salicylic acid glucoside, salicylic acid fatty acid ester, salicylic acid alcohol ether, salicylic acid amides, etc.), salicyl alcohol or a salt thereof and derivatives thereof, apigenin, and amentoflavone. , Salamander extract, Udo extract, Shishido extract, Nirinso extract, Oak extract, Beef Taxi extract, Cuckoo thistle extract, Gypsophila extract, Gymnema sylvestre extract, Carrion extract, Ginkgo biloba extract, Konronka extract, Sabinryo extract, Jasmine (pine licorice) extract, hollyhock extract, scallop extract, Arabidopsis extract, lily of the valley extract, sow extract, deco extract, eucommia extract, nagii Da (Butcher Bloom) Extract, Teppouri Extract, Tokiwa Mansaku Extract, Nankin Gouze Extract, Elderberry Extract, Nadesico Extract, Mite Willow Extract, Sardine Willow Extract, Morohaya Extract Zakifujime extract, Ryokakou extract, Ajigusa extract, shellfish extract (cockle extract, green mussel extract, oyster extract, European oyster extract, scallop extract, clam extract, clam extract, bakagai extract, ishi mussel extract, red mussel extract, abalone extract, Sazae extract, bi-extract, etc.).

Humectant A humectant can be added to the preparation of the present invention. Specific examples of moisturizers include gum arabic, benzoin rubber, danmar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum, carob gum, quince seed, agar or its derivatives, casein, glucose, galactose, mannose, xylose, fructose, maltose, iso Maltose, cellobiose, gentiobiose, trehalose, cordierbiose, laminaribiose, nigerose, sambubiose, neohesperidose, apiose, hammamellose, streptose, hydroxystreptose, dihydrostreptose, 2-methylerythrose or derivatives thereof, 2-methylerythrono Lactone, micalose, cladinose, accessose, alkanose, olivomai course, chromose, ebamise, vinerose , Sugars such as nogarose, bilenose, nobiose, moenuronic acid, galosamine, cybirosamine, N-acylcansosamine, vancosamine, evanitrose, rubranitrose, tetronitrose, pyralose, α-octose, trioxacalcinose, aldgarose, blastminosin 1,3-butylene glycol, glycerin, propylene glycol, polyethylene glycol, dipropylene glycol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,6-hexanediol, mannitol and Sorbitol, ethanediol, diethylene glycol, triethylene glycol, 2-amino-2-methyl-1,3-propanediol, 1,2-propanediol, 1,3-propanediol, polypropylene glycol, 1,2-butyl Diol, 1,3-butanediol, 1,4-butanediol, isopentanediol, pentylene glycol, hexylene glycol, 1,3-pentanediol, 1,4-pentanediol, 1,2,3-pentanetriol, 2,3,4-pentanetriol, 1,3,4-pentanetriol, 1,3,5-pentanetriol, 1,3-hexanediol, 1,4-hexanediol, 1,5-hexanediol, 1, 2,3-hexanetriol, 1,3,4-hexanetriol, 1,3,5-hexanetriol, 1,4,6-hexanetriol, erythritol, pentaerythritol, dipentaerythritol, threitol, arabitol, xylitol, Ribitol, galactitol, lactitol, maltitol, inositol, panthenol, laminitol, valienamine, validamine, validatitol, trehalose Is a derivative thereof, D-mannosamine and its derivative, isomaltoligosaccharide (panose), primeverose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, alkylene (C2-C4) oxide such as ethylene oxide Is added hydroxyalkyl (C2-C4) chitin or chitosan, low molecular chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or Its salt, β-1,3-glucan, β-1,4-glucan, β-1,6-glucan, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose, carboxyethylcellulose, sodium carboxyethylcellulose, hydroxy Polyalkylene oxides such as chill cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, hydroxypropyl methylcellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyethylene oxide and polypropylene oxide or cross-linking polymerization thereof. Water-soluble polymers such as carboxyvinyl polymer, polyethyleneimine, dermatan sulfate, keratan sulfate, glycerin fatty acid pyrrolidone carboxylic acid ester, glycerin fatty acid acetyl amino acid ester, pyrrolidone carboxylic acid or salt thereof, polyaspartic acid or salt thereof , Polyglutamic acid or its salt, polylysine or its salt, sodium lactate, hydantoin and its derivatives Np-vinylbenzyl-D-cellobionamide, Np-vinylbenzyl-D-lactone amide, Np-vinylbenzyl-D-maltonamide, Np-vinylbenzyl-D-gluconamide, glucosyloxyethyl methacrylate, galactosyloxy Propyl acrylate, mannosyloxyethyl methacrylate, glutamyl lysine, glutaurine, 1,2,4-butanetriol, caran-3,4-diol, azoxaponin (3-o- [β-D-glucopyranosyl-β-D-glucurono Pyranosyl] -sophoradiol, 3-o- [β-D-glucopyranosyl-3-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D- Glucuronopyranosyl] -azuxapogenol, 3-o- [β-D-glucopyranosyl] -28-o- [β-D-glucopyranosyl-β-D-glucopyranosyl] -dipsogenic acid, 3-o- [ α-L-rhamnopyranosyl-β-D-glucopyra Sil-β-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -29-o- [β-D- Glucopyranosyl-β-D-glucopyranosyl] -azuxapogenol , Maruba morning glory extract, morning glory extract, Athira (shokuyo kanna) extract, oilseed rape extract, amachazul extract, amana extract, Ayuyu extract, Hagateto extract, Hyugaito extract, Senninkoku extract, Sugimorige Ito extract, Hosoa Otome extract, Aogateto extract, Haribiyu extract, Aozulan extract, Amaranthus hippocondri Cus extract, Aristolomeria (Yurizuisen) extract, Arcana (alcanna) extract, Argarobo (cabbe) extract, Aloe vera extract, rush (1) , Dog mint extract, sardine tobacco (Iwabuchi) extract, iwahiba extract, sardine pine (roll mushroom) extract, wheat (chibusanoki) extract, duckweed (float) extract, euglena thrips extract, euglena extract, unyadegato (uncaria) extract, enokitake (榎 茸) extract, eringi extract, pre-lotus eringi extract, ogatahouken extract, oguruma (civil engineering incense) extract, euglena (cereal essence) extract, oka extract, okazeli (serpentine) extract, okra extract, onidokoro extract, Tokoroe Kiss, Nagadokoro (Hikai) extract, Ononis extract, Yuuko extract, Oyster extract, Ginseng extract, Gaku hydrangea extract, Cascara sagrada extract, Gypsophila extract, Panax ginseng extract, Kaniwa extract, Carnation extract, Gerbera extract, Camcam (camo duck) ) Extract, Color extract, Oat extract, Karin (Kiso) extract, Kawara Psycho (compulsed rape, tranquilized white grass) extract, Kawajisha extract, Kawaranadeshiko (stone bamboo) extract, Ezokawaranadeko (Soba, buckwheat) extract, Kantarasaasa extract, Kikutaniku extract, quinoa extract, cabbage extract, kiwi extract, cucumber extract, gyory (Nishikawa willow, teyanagi) extract, Kirangsou (golden grass weed) extract, guayule extract, Kusagisuzuki (Tenmon winter) extract, kudzu ) Extract, ginseng (yellow flower bud) extract, cupuas extract, gumbai tuna (Sekimei, Sekimeishi) extract, Kemponashi (Kigushi) extract, gekkavidin (Beautiful under the moon) extract, Kouren (Huo Ren) extract, coconut extract, cosmos extract, co Button leopard extract, rice oil extract, konjac extract, saffron (banban flower, west red flower) extract, sapodilla extract, sangre degrad (croton) extract, sanchinin ginseng (37 ginseng) extract, shea (carite) extract, cyanoki extract, shiitake mushroom extract Shiitake extract, shimeji mushroom extract, hin-shimeji mushroom extract, shaka shimeji mushroom extract, hatake shimeji mushroom extract, oshiroi shimeji mushroom extract, beech shimeji mushroom extract, honji mushi extract, shirotamogitake extract, shimokren extract , Ryukyu Kasamisou Extract, Ryukyu Hydrangea (Tsunayama) Extract, White Rooster Butterfly Extract, White Clover (Chicken Bones) Extract, Ginkgo biloba (Mizuka, Ryoka Flower, Shencho Flower) Extract, Watermelon (Sairan) Extract, Suzu-Psycho (Xulongan) Extract, Surihiyu (Horse Soap, Horse Teeth) Extract, Sekkoku Extract, Sakura Sekkoku Extract, Koki Sekkoku Extract, Obanase Sekkok Extract, Okinawa Sekkok Extract, Hon Sekkokoku Extract, Shika Sekkokoku Extract, Kiba Nano Sekkok Extract, Cedron (Boushuboku) extract, mallow extract, celery extract, senshinren (baffled ream) extract, Japanese radish (radish) extract, Takasaburo (Boku lotus) extract, Tachidokoro (hikai) extract, dahlia (tenjiku button) extract, tarwi extract, sen Kinshi extract, soju Tulip extract, Chanca Piedra extract, Tulip extract, Chorogi extract, Tsukuritake mushroom extract, camellia extract, camellia extract, Tounabena extract, corn extract, corn hair , Toxa (wood bandits) extract, ash (crustacean) extract, turkey falcon extract, peanut extract, vertical blade (sword bean) extract, jujube (large cocoon) extract, navena (continuous) extract, nameco extract, namban ramie (cannabis) extract , Niois violet extract, nutmeg extract, Nemum extract, Nebu extract, Nebi extract, Nemkinoki extract, Digokubana extract Extracts Extract, bell pepper extract, Japanese apricot extract, Japanese pine bamboo (Kawariharatake, Hiromatsutake) extract, eucheuma (Coleoptera) extract, Brazilian licorice extract, hazelnut extract, loofah extract, red-breasted extract, Ikusa (jingten) extract, Bakigi extract, Chrysanthemum extract, Nendodon extract, Hahagigi Kokia (geum coconut) extract, spinach (Akansen, Acute pupa, Periosteum) extract, Diptera edulis extract, Hosobakirinso (Keiten zosan) extract, Jojoba Kiss, Borage extract, Bordeaux extract, Hononiku (meat juju, Taigei) extract, Honsekkok (iron skin stone, Sparrow mountain stone) extract, Maca extract, Macadamia nut extract, Margaret (Mokushungiku) extract, Tamanozen Hallen Extract, kyukonkinrenka extract, matatabi (wooden cocoon) extract, pine coconut extract, matsuhodo (cocoon) extract, matico (cordon sillo) extract, quince extract, malein (biloudomozuika) extract, manzanya (andesukamitsuru) extract, mizusobako extract , Japanese morning glory extract, green mint extract, wheat straw extract, munya extract, purple extract, purple purple extract, purple jelly extract, moge extract, mochinoki extract, Yag Masowa extract, Yacon extract, Palm extract, Yabu tobacco (Tsurugai, Tenmeisei) extract, Maronnier extract, Mokka extract, Lily extract, Raigan (Raimaru) extract, Lime extract, Rye extract, Rakkyou extract, Shallot (palm white) extract, Apple extract , Gentian extract, litchi (piper, toothpick) extract, lotus extract, yokuinin extract, minisasaniki extract, chlorella vulgaris extract, chlorella pyrenoid extract, chlorella ellipsoidia extract, macrocystis pirifera extract, euquiri extract , Tosakanori extract, Cyprinus extract, Amakusa Nori extract, Aoimidro extract, Kawanoori extract, Marimo extract, Mochikihitoe extract, Ezoyahaz extract, Habanori extract, Atlantic havanori extract, Cottontail extract, A Extract, squirrel extract, trolley extract, antokume extract, pickled alley extract, black squirrel extract, cat corn extract, Ainu turtle extract, chigaiso extract, squirrel extract, yabanemoku extract, trumpet extract, uganomoku extract, joromoku extract, hyamok extract, tamanashi moku extract, Honda Walla Extract, Sugi Moku Extract, Bovine Kenori Extract, Susabi Nori Extract, Akebono Mozuku Extract, Sea Elephant Swine Extract, Fusanori Extract, Hoso Banamino Hana Extract, Hanaf nori Extract, Itohnori Extract, Kaginori Extract, Mirin Extract, Hoso Bamirin Extract, Chrysanthemum Extract, Ezonameshi Extract Ibaranori Extract, Kaigai Baranori Extract, Saidaibara Extract, Tachiibara Extract, Ogonori Extract, Tsurushiramoeki , Bee Zhou Gelidium nilotica extract, Okitsunori extract, Aqaba ginkgo Saw extract, natto culture metabolites, natto extract, sponge gourd water, birch (birch) or Akamatsu sap, and the like.

Cell activating agent / metabolic activator A cell activating agent / metabolic activator can be added to the preparation of the present invention. Specific examples of cell activators and metabolic activators include vitamin A group: retinol or its salts and derivatives thereof (retinyl unsaturated fatty acid esters such as retinyl linoleate, retinyl linolenate, retinyl oleate, retinyl arachidate, etc.) ), Retinal or a salt thereof and derivatives thereof, dehydroretinal or a salt thereof and derivatives thereof, retinoic acid or a salt thereof and derivatives thereof, retinoic acid analog (4-[[[8- (3,5-dimethylphenyl ) -2-Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3-methylphenyl) -2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[[8- (4-methylphenyl) ) -2-Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3,4- Dimethylphenyl) -2-naphthaleni ] Carbonyl] amino] benzoic acid, 4-[[[8- (2,4-dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-isopropylphenyl) -2 -Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-ethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-fluorophenyl) -2 -Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methoxyphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(8-benzyl-2-naphthalenyl) carbonyl] Amino] benzoic acid, 4-[(E) -2- (8-phenyl-2-naphthalenyl) propenyl] benzoic acid), retinoic acid derivative (4-hydroxyphenylretinamide), retinoid analogue (4-[[( 5,6-dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) Amino] Kerr Bonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5, 5-dimethyl-8-ethyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) -carbonyl] amino] benzoic acid, 4- (E)-[2- (5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) -1-propenyl] benzoic acid, 4-[[((5,6-dihydro-5 , 5-Dimethyl-8-phenyl-2-naphthalenyl) oxy] carbonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] amino] Benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] oxy] benzoic acid, 4-[[5,6-dihydro-5,5- Dimethyl-8- (2-fluorophenyl) -naphthalenyl] carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5,6-trimethyl) ] -8-phenyl-2- (naphthalenyl) carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5,7-trimethyl-8-phenyl-2-naphthalenyl) carbonyl] benzoic acid, 4-[[((E)-(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] vinyl] benzoic acid, 4-[[[((5,6-dihydro-5,5 -Dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] sulfamyl] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] sulfamyl] carbonyl] benzoic acid Acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl -8-phenyl) -2-naphthalenyl] thiocarbonyl] amino] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] methyl] benzoic acid Acid, 4-[[[((5,6-Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] oxy] benzoic acid Acid 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthenyl] oxy] methyl] benzoic acid, 4-[[[((5,6-dihydro-5, 5-dimethyl-8- (2,4-dimethylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8- (4- Methylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4- [ [[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] sulfamyl] methyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8- Phenyl) -2-naphthalenyl] methyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] amino] thiocarbonyl] benzoic acid, 4 -[[[((5,6-Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] sulfamyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl - 8-phenyl-2-naphthalenyl] amino] methyl] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-hydroxy Benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-nitrobenzoic acid, 4-[[[((5,6 -Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-fluorobenzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-Naphthalenyl] carbonyl] amino] -2-methoxybenzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8- (2-naphthalene)]-2-naphthalenyl] carbonyl] amino ] Benzoic acid, 4-[[(5,6-dihydro-8-phenyl-2-naphthalenyl) carbonyl] aminobenzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl- 2-Naphthalenyl) carbonyl] amino] -3-fluorobenzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl) Enyl-2-naphthalenyl) carbonyl] amino] -3-methylbenzoic acid, 4-[[((5,8,10,10a-tetrahydro-10,10-dimethyl-9-phenyl-2-anthracenyl) carbonyl] amino] Benzoic acid, 4-[[(1,1-dimethyl-3-phenyl-1H1-inden-5-yl) amino] carbonyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-indene -5-yl-oxymethyl) benzoic acid, 4- [2- (1,1-dimethyl-3-phenyl-1H-inden-5-yl) vinyl] benzoic acid, 4-[(1,1-dimethyl- 3-phenyl-1H-indene-5-carbonyl) amino] benzoic acid), carotene or salts thereof and derivatives thereof (α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthine, lutein, zeaxanthin, isoseaxanthin, rhodoxanthine , Carotenoids such as capsanthin and crocetin), lycopene or its salts and derivatives thereof, vitamin B group: thiami Or salts thereof and derivatives thereof (thiamine hydrochloride, thiamine disulfide, bisbenchamine, bisbutiamine, thiamine monophosphate disulfide, benfotiamine, chicotiamine, octothiamine, discetiamine, fursultiamine, prosultiamine, astaxanthin Thiamine phosphate diester, etc.), thiamine sulfate, riboflavin or its salts and derivatives thereof (flavin adenine dinucleotide, flavin mononucleotide, riboflavin phosphate diester, 1-β-D-ribofuranosylnicotinamide pyrophosphate diester, 1 -β-D-ribofuranosylnicotinic acid, etc.), pyridoxine or its salts and derivatives thereof (pyridoxine 3,4-dipalmitate, pyridoxine 3,4-dicaprylate, pyridoxine sulfate diester, etc.), pyridoxer Or salts thereof and derivatives thereof, pyridoxamine or salts thereof and derivatives thereof, cyanocobalamin or salts thereof and derivatives thereof, cobalamines (such as methylcobalamin, adenosylcobalamin, hydroxocobalamin, aquacobalamin), folic acid or salts thereof, and Derivatives thereof, nicotinic acid or salts thereof and derivatives thereof, pantothenic acid or salts thereof and derivatives thereof, biotin or salts thereof and derivatives thereof, choline or salts thereof and derivatives thereof, inositol or salts thereof and derivatives thereof , Vitamin C group: ascorbic acid or a salt thereof and derivatives thereof, vitamin D group: ergocalciferol or a salt thereof and derivatives thereof, cholecalciferol and a salt thereof and derivatives thereof (1α-hydroxy-22-[(1 -Hide Xyl-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1R, 4R] -1α-hydroxy-22-[(1- Hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1R, 4S] -1α-hydroxy-22-[(1- Hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1S, 4R] -1α-hydroxy-22-[(1- Hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1S, 4S] -1α-hydroxy-22-[(1- Hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, etc.), dihydrotaxosterol or a salt thereof and derivatives thereof, vitamin E group : Tocopherol or a salt thereof and a derivative thereof, Tocotrie Nord or a salt thereof and derivatives thereof, ubiquinone or a salt thereof and derivatives thereof, vitamin K group: phytonadione or a salt thereof and derivatives thereof, menaquinone or a salt thereof and derivatives thereof, menadione or a salt thereof and derivatives thereof, menadiol Or salts thereof and derivatives thereof, vitamin F group: linoleic acid or salts thereof and derivatives thereof, linolenic acid or salts thereof and derivatives thereof, arachidonic acid or salts thereof and derivatives thereof, carnitine or salts thereof and Derivatives, ferulic acid or a salt thereof and derivatives thereof, γ-oryzanol or a salt thereof and derivatives thereof, orotic acid or a salt thereof and derivatives thereof, vitamin P group: rutin or a salt thereof and derivatives thereof, eriocitrin or a derivative thereof Salt and it Derivatives, hesperidin or salts thereof and derivatives thereof, vitamin L group: anthranilic acid or salts thereof and derivatives thereof, adenylthiomethylpentose or salts thereof and derivatives thereof, vitamin U group: methylmethionine sulfonium chloride or derivatives thereof , Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, Histidine or its derivatives (N-octyloxycarbonyl-β-alanyl-L-histidine, N-dodecyloxycarbonyl-β-alanyl-L-histidine, N- (12-amino-1-oxo Dodecyl) -L-histidine, N-2-ethylhexyloxycarbonyl-β-alanyl-L-histidine hydrochloride, N-hexadecyloxycarbonyl-β-alanyl-L-histidine, N-octylaminocarbonyl-β-alanyl- L-histidine, N-dodecylaminocarbonyl-β-alanyl-L-histidine, N-dodecylsulfonyl-β-alanyl-L-histidine, N-dodecylamino-oxalyl-β-alanyl-L-histidine, etc.) Amino acids such as sulfates, phosphates, nitrates, citrates or amino acid derivatives such as pyrrolidone carboxylic acid, α-hydroxy acids such as glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, succinic acid, 2-hydroxycarboxylic acids (methyl lactic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid, 2-hydroxyheptanoic acid, 2-hydroxy Tannic acid, 2-hydroxynonanoic acid, 2-hydroxydecanoic acid, 2-hydroxyundecanoic acid, α-hydroxylauric acid, α-hydroxymyristic acid, α-hydroxypalmitic acid, α-hydroxystearic acid, α-hydroxyarachidonic acid , Cerebronic acid, α-hydroxynervonic acid, mandelic acid, benzylic acid, phenyllactic acid, atrolactic acid, 2- (4'-hydroxyphenyl) -2-hydroxyethanoic acid, 2- (4'-chlorophenyl) -2-hydroxy Ethanoic acid, 2- (3′-hydroxy-4′-methoxyphenyl) -2-hydroxyethanoic acid, 2- (4′-hydroxy-3′-methoxyphenyl) -2-hydroxyethanoic acid, 3- (2 ′ -Hydroxyphenyl) -2-hydroxypropanoic acid, 3- (4'-hydroxyphenyl) -2-hydroxypropanoic acid, 2- (3 ', 4'-dihydroxyphenyl) -2-hydroxyethanoic acid, glyceric acid, erythrone Acid, ribo Acid, arabinonic acid, xylonic acid, lyxonic acid, aronic acid, altronic acid, gluconic acid, mannonic acid, gulonic acid, idonic acid, galactonic acid, taronic acid, glucoheptonic acid, galactoheptonic acid, tartronic acid, mucinic acid, etc.), poly Hydroxycarboxylic acid or hydroxypolycarboxylic acid (gluconolactone, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, saccharide lactone, pantoyl lactone, glucoheptonolactone, mannonolactone, galactoheptono Lactones), 2-keto acids (glyoxylic acid, methyl 2-ketoethanoate, benzoylformic acid, methyl benzoylformate, ethyl benzoylformate, phenylpyruvic acid, methyl phenylpyruvate, ethyl phenylpyruvate, 2-ketobutanoic acid, 2- (Ketopentanoic acid, 2-ketohexanoic acid, 2-ketoheptanoic acid, 2-ketooctanoic acid, 2-ketododecanoic acid, methyl 2-ketooctanoate, etc.), quinic acid, isocitric acid, tropic acid, tretocanic acid, 3-chlorolactic acid, cerebronic acid , Citramalic acid, agaricinic acid, aleuricinic acid, pantoic acid, lactobionic acid, hexulosonic acid, photosensitizer 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, pentadecanoic acid glyceride, linolenic acid or derivatives thereof, eicosapentaenoic acid or derivatives thereof Docosahexaenoic acid or a derivative thereof, estradiol, etenyl estradiol, antialol or a glycoside thereof, rioniresinol or a glycoside thereof, rhododendrol or a glycoside thereof, platyphyronol or a glycoside thereof, a lactone compound (D -Guruk Rono-6,3-lactone, α-D-glucoheptonic-γ-lactone, δ-glucuronolactone, α, β-glucooctonic-γ-lactone, L-glonic-γ-lactone, γ-D- Galactonolactone, D-saccharide-1,4-lactone, D-saccharide-3,6-lactone, D-ribonic-γ-lactone, α-butyrolactone, γ-butyrolactone, α-octanoic lactone, γ-octa Neutic lactone, Nonanoic lactone, γ-valerolactone, D-manninoic-δ-lactone, D-xyleuic-δ-lactone, D-arabinoic-δ-lactone, stearoyl-δ-gluconolactone, DL-pantolactone, Palmitoyl-DL-pantolactone, etc.), 3-hydroxy-3,4-dicarboxy-1,4-butanolide or derivatives thereof, 6-benzylaminopurine or derivatives thereof, 1,4-diazadicyclooctane, 2,5 -Dimethylfuran, 2 -Methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran, rutin, tectrigenin 7-xylosylglucoside, captopril, alacepril, lisinopril, enalapril, delapril, benazepril, cilazapril, imidapril, quinapril, trandlapril Perindopril, temocapril, losartan, endothelin, galactomannan saccharide polymer, mucin, trimethylglycine, proteoglycan, lactic acid bacteria extract, lactic acid bacteria culture extract, lactic acid bacteria fermented milk extract, bifidobacteria extract, bifidobacteria culture extract, bifidobacteria fermented milk extract, Placenta extract, reishi extract, spleen extract, thymus extract, yeast extract, yeast culture extract, yeast fermentation extract, filamentous fungus extract, filamentous fungus culture extract, basidiomycete extract, basidiomycete Culture fluid extract, Bacterial cell disruption extract, Bacterial culture fluid extract, Cultured human dermis cell disruption extract, Red sage extract (Early yellow) extract, Fennel (mushroom) extract, Ezokogi (Tomogoka) extract, Barley (barley) extract, O Kururi Higotai (Zhengzhou Leopard) Extract, Root-knotweed Extract, Hypericum perforatum Extract, Dutch Jelly Extract, Dutch Honeybee Extract, Silkworm Extract, Roman Chamomile Extract, Garcinia Extract, Kawaran Ginseng (Blue Panax) Extract, Kakiran Extract, Kiraya Extract, Golden orchid extract, Ginkgo biloba extract, Calendula extract, Sakaneran (Ezosakakaneran) extract, Sababagin orchid extract, Sawagurumi extract (Plum) extract, Shimosukeso extract, Shajin extract, Plum extract, Gurumi extract, Sugina extract, Pineapple Pull extract, Chinese cabbage extract, Japanese cypress (shooting) extract, beech extract, physalis (Torone) extract, maitake (maiko) extract, Misohagi (Chikuma) extract, Mukuge (Kiso) extract, Mukuroji (life extension skin) extract, sprout Extract, Eucalyptus extract, Yukinoshita (tiger ear grass) extract, Suabisimus (cool) extract, Lettuce (Chisha) extract, Aloe extract, Ogon extract, Tonka bean extract, Gentianana extract, Burdock extract, Shikon extract, Carrot extract, Hamamelis extract, Hop extract, Yokuinin extract, Odorikosou extract, Senburi extract, Toki extract, Ginseng extract, Achacha extract, Hypericum extract, Cucumber extract, Ginger extract, Rosemary extract, Parsley extract, Sanadagusa extract, Fukurinamiji extract, Gatsu Lacombe Extract, Oyster Kumbu Extract, Oni Kumbu Extract, Gohei Kombu Extract, Naga Kumbu Extract, Pea Kombu Extract, Ouchimikombu Extract, Rattle Extract, Rattle Rape Extract, Beni Mozuku Extract, Hoso Beni Mozuku Extract, Kagekinori Extract, Ezotosaka Extract , Silamo extract, birch extract and the like.

Antioxidants Antioxidants can be added to the formulations of the present invention. Specific examples of antioxidants include ascorbic acid or a salt thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl hydroxyprophosphate, 5-o-α -D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid Sulfate aluminum Nium salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyranosyl -L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl-L -Ascorbic acid, 6-o-alkylascorbic acid potassium phosphate, 6-o-alkylascorbic acid phosphate calcium Um salt, 6-o-alkyl ascorbic acid phosphate barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o-alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl ascorbine Acid phosphate ester diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine Salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate Cholesterol ester, L-ascorbyl palmitate, L-isopalmitate Scorbyl, L-ascorbyl dipalmitate, L-ascorbyl diisopalmitate, L-ascorbyl stearate, L-ascorbyl isostearate, L-ascorbyl distearate, L-ascorbyl diisostearate, L-ascorbyl myristate, isomyristic acid L-ascorbyl, dimyristic acid L-ascorbyl, diisomyristic acid L-ascorbyl, 2-ethylhexanoic acid L-ascorbyl, di-2-ethylhexanoic acid L-ascorbyl, oleic acid L-ascorbic acid, 2-o-α -D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D- Glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitin Ester, L-Ascorbic acid tetralauric acid ester, L-Ascorbic acid tetra-2-ethylhexanoic acid ester, L-Ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol Ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbine Acid triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl] -4 ' -Acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphate diester, ascorbic acid boar Binding derivatives, ascorbic acid phosphoramide derivatives, ascorbic acid arbutin conjugates, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivatives, ascorbic acid sialic acid derivatives, etc.), stearates, tocopherols or their salts and derivatives thereof (α-tocopherol) , Β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate, tocopherol succinate , Tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl Glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-toco Ferryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ- Tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ -Tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- (sulfoethylamino) -3- (α-tocopheryl-6- (Iloxy) propan-2-ol, 1- (carbo Cypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-Tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxy Propyl] aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ- Tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate), dihydropyridine derivatives (methyl-3- Enyl-2-propenyl 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) pyridine-3,5-dicarboxylate and its salts), benzochroman derivatives, nordihydrogua ceretenoic acid, butyl Hydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, coenzyme Qn (n = 7-10), pyrroloquinoline quinone, propyl gallate, sesamol, sesamolin, gossypol, maritimane, sulfretin, xanthene -2,7-diols, caffeoylquinic acids, propolis, carotenoids (α-carotene, β-carotene, γ-carotene, lycopene, lutein, violaxanthin, spiroloxanthine, spheroidene, astaxanthin, etc.), fluorotannin, Akebi extract, Achacha extract, Oolong Chaeki , Dutch biloba extract, kanran extract, kumquat extract, gobishi extract, ginseng extract (old lady's grass) extract, sesame extract, sesame cell extract, sesame extract, ginseng extract, rice bran extract, pomegranate extract, salamander extract, pear Extract, Daio extract, Tomato extract, Nanten extract, Noami (Otsuchi) extract, Neubara extract, Paprika extract, Pistachio extract, Biwa extract, Betel nut extract Buffalo extract, Bokeh extract, Hosobaoguruma extract, Mao (mao) extract, Mimosa extract, Mebouki extract, Himekuma willow extract, Yanagita extract, Watafujitsugi extract , Akaba Miuchiwa extract, Examples include Hypericum extract, Clam extract, Clove extract, Melissa extract, Enmezo extract, Birch extract, Salvia extract, Rosemary extract, Nanten extract, Ginkgo biloba extract, Green tea extract, Clove extract and the like.

Active oxygen scavenger / radical scavenger An active oxygen scavenger / radical scavenger can be added to the preparation of the present invention. Specific examples of active oxygen scavengers and radical scavengers include superoxide dismutase, catalase, glutathione peroxidase, bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or derivatives thereof, gallic acid or salts thereof, and derivatives thereof, curcumin Or salts thereof and derivatives thereof, transferrin, ceruloplasmin, coenzyme Qn (n = 7 to 10), uric acid, bilirubin, metallothionein, stilbengaloyl glycoside (3,5,4′-trihydroxystilbene 4′-o -β-D- (6 "galloyl) glucopyranoside, 3,5,4'-trihydroxystilbene 4'-o-β-D- (2" galloyl) glucopyranoside, etc.), chlorogenic acid phospholipid ester, chlorogenic acid sphingosine ester And derivatives thereof, chlorogenic acid glycolipid ester, chlorogenic acid sugar Steal, chlorogenic acid sterol ester, thiazole derivative or salt thereof (2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxyphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- [3-carboxy-4-hydroxy-5- (2-methyl-2-propenyl) phenyl] thiazole and 2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxy- 5-methylphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- (3-carboxy-5-methoxyphenyl) thiazole), hydroxymatylesinol, allohydroxymatylesinol, hydantoin derivatives, (Logwood) extract, Akagasiwa (red bud) extract, Acamino red extract, Japanese red plant extract, Japanese red radish extract, Hydrangea (hydrangea) extract, Abemaki extract, Fig extract, Ginkgo biloba extract, Asparagus Extract, Japanese apricot extract, Japanese white extract, Japanese walrus extract, Estragon extract, Enju (Japanese cypress, Japanese rice) extract, Japanese oak (Japanese cypress, Japanese coconut leaf) extract, Japanese cabbage extract, birch extract, birch extract, Kunugi extract, Oleander extract, Kumiko mandarin (Koji, Tachibana, Obenimikan, Fukurikukan, Sagamikoji, Ponkan) extract, Santara extract, Coffee extract, Comfrey extract, Sasa extract, Perilla extract, Aojiso extract, chili mushroom extract, catamen diso extract, peonies (glaze) extract, Japanese oak extract, mizunara extract, crape myrtle extract, dicoppi extract, white birch extract, white clover (clover) extract, horseradish extract, black tea extract, green tea extract, tsububuki Extract, tencha (bamboo tea) extract, tender eel extract, nani waibara (gold cherry tree) extract, peanut (peanut) extract, kei extract, nikkei extract, ceylon nicki extract, yabuni kei (cinnamon) extract, keishi (katsushi) extract, nozenkazura Extract, Lotus (Lotus) Extract, Chinese cabbage extract, Hadamakugi Extract, Hanasuge (Kamika) Extract, Hermanus (Maika Flower) Extract, Rose (Rose) Extract, Barbasco Extract, Spinach Extract, Beech Extract, American Beech Extract, Dog Beech Extract, European beech extract, Convolvulus extract, Hosobaokera (蒼朮) extract, Button (peony) extract, Mayoram (Annelida) extract, Melon extract, Oenothera extract, Snowy willow extract, Orchid extract, Lacanca extract, Rooibos extract, Naminohana extract, Yukarie Vinegar, bombardier Yukari extract, Azusaekisu, basil extract, woodworking (climate) extract, Hime Fuuro extract, lemon grass extract, and the like.

Fat Metabolism Promoter A fat metabolism promoter can be added to the preparation of the present invention. Specific examples of fat metabolism promoters include phthalazine derivatives (4-ethyl-1- (β-hydroxyethylamino) phthalazine, 4-N-propyl-1- (β-hydroxyethylamino) phthalazine, 4-N-butyl- 1- (β-hydroxyethylamino) phthalazine, 4-N-butyl-1- (β-hydroxypropylamino) phthalazine, etc.), xanthine derivatives (caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, diprofylline, proxy) Phyllin and oxtriphilin, etc.) Extract, Gajuttsu (boiled) extract, Chrysanthemum salmon extract, Kyoko Root) Extract, Ivy Extract, Pepper (Pepper) Extract, Cola Acminata Extract, Sagiomodaka (Sawamata) Extract, Pomelo Extract, Sansyuyu (Yamamuro) Extract, Tsuba Rafuji Extract, Ootsuki Rafuji Extract, Choreimaitake (Amber) Extract, Clover Extract , Prickly pear extract, red ginseng extract, ginseng extract (dragon gall) extract, naginata kouju extract, banana extract, puer tea (common ear tea) extract, plum extract, boufu (windproof) extract and the like.

UV protection agent / UV absorption promoter A UV protection agent / UV absorption promoter can be added to the cosmetic composition of the present invention. Specific examples of UV protection agents and UV absorption accelerators include benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5- Sodium sulfonate, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), 1,2-dihydroxy-4- (2-hydroxyethyl) benzene derivatives (1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) -3- Rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (2-acetyl-4- (3,4-dihydroxycinnamoyl) -3-rhamno L) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (2-acetyl-6- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (6- (4-hydroxy-3-methoxycinna) Moyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-methoxyethyl-3, 4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-hydroxyethyl-3,4-dihydroxybenzene, 1- (2- (6- (3,4-Dihydroxycinnamoyl) -3-xylosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (3-arosyl-6- (3-hydroxy-4-methoxycinnamoyl) ) Glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (3-glucosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1 -(2- (3-Allosyl-6- (3-hydroxy-4-methoxycinnamoyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (4- (3,4-dihydroxycinna Moyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (3- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (2 -(3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene Paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, paradimethyla Amyl benzoate, octyl paradimethylaminobenzoate), methoxycinnamate derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, paramethoxycinnamate Potassium, diparamethoxycinnamate mono-2-ethylhexanoate glyceryl, etc.), anthranilic acid derivatives (such as methyl anthranilate), urocanic acid derivatives (such as urocanic acid, ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, Tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, pyridoxine derivatives, Pyridoxal derivative, pyridoxamine derivative, amethoflavone, neosacranin, 6-dehydrocarbine, triazine derivative (4,4'4 "-(1,3,5-triazine-2,4,6-triyltriimino) trisbenzoic acid tris- 2-ethylhexyl etc.), phosphatidyl chromanol derivatives (1,2-dilaurylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman 1,2-dimyristoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-dipalmitoylglycero-3- Phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-distearoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-Tetramethyl-6'-hydroxychroman, 1,2-dialachidonylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'- Tramethyl-6′-hydroxychroman, 1-myristoyl-2-palmitoylglycero-3-phospho-2′-hydroxymethyl-2 ′, 5 ′, 7 ′, 8′-tetramethyl-6′-hydroxychroman, 1- Myristoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-palmitoyl-2-myristoylglycero-3-phospho -2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-palmitoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6'-hydroxychroman, 1-stearoyl-2-myristoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetra Methyl-6′-hydroxychroman, 1-stearoyl-2-palmitoylglycero-3-phospho-2′-hydroxymethyl-2 ′, 5 ′, 7 ′, 8′-tetramethyl-6′-hydroxychroman, etc.) , L-carnosine zinc complex, umbelliferone, esculin, benzyl cinnamate, cinoxalate, oxybenzone, dioxybenzone, octabenzone, soribenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, chlorophylls, xanthophylls , Escalol, Zinc Oxide, Talc, Kaolin, Anthrac (Buckthorn) Extract, Hub Extract, Giant Plover Extract, Asamidori Shigusa Extract, Kawachigusa Extract, Kawatake Extract, Cypridosa Extract, Hassai Extract, Spirulina Extract, Iacashio Extract, Funori no Ushike Extract , Japonica extract, Hytengus extract, Oobusa extract, chinolimo extract and the like.

Astringents Astringents can be added to the formulations of the present invention. Specific examples of astringents include succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannins (tannic acid, hamamelitannin Acer tannin, tetragalloyl glucose, pentagalloyl glucose, hexagalloyl glucose, heptagalloyl glucose, octagalloyl glucose, nonagaroyl glucose, decagalloyl glucose, undecagalloyl glucose, dodecagalloyl glucose, etc. Gallotannins, telimaglandin I, telimaglandin II, casarictin, peduncraggin, geraniin, isotarkevin, granatin A, granatin B, ketulinic acid, keblagic acid, casuarinin, nuphalin, procyanidin B-2, Eladitannins such as thiacinensin A and thiacinensin B), red grape extract, red bean extract, altea extract, nettle extract, cascarilla extract, kapoch extract, guarana extract, ezoba strawberry extract, Dutch strawberry extract, shrimp strawberry extract , Nawashiro Strawberry Extract, Maple Strawberry Extract, European Raspberry Extract, Kidney Aloe Extract, Hawthorn Extract, Coustella Hakka Extract, Cowberry (Etsutachibana) Extract, Cola Vera Extract, Sugarcane Extract, Sinah Honoki Extract, Honeysuckle Extract Q) Extract, larch extract, elder extract, dandelion extract, centalium extract, white dandelion extract, mud dandelion extract, vine azuki bean extract, tsurutsu Akebi extract, Teuchigurumi extract, Tormentilla extract, Novara extract, Buttercup extract, Hagoromogusa extract, Castor extract, Grape extract, Prune extract, Veronica extract, Bisnaga extract, Bilberry extract, Mansuguru extract, Mitsugashi extract, Myrrh extract, Melissa extract, Examples include witch hazel extract, black willow extract, latania (chlamelia) extract, lemon extract, and dairy extract.

Anti-inflammatory agent / interleukin production inhibitor / histamine release inhibitor An anti-inflammatory agent / interleukin production inhibitor / histamine release inhibitor can be added to the preparation of the present invention. Specific examples of anti-inflammatory agents, interleukin production inhibitors and histamine release inhibitors include quinolinone derivatives, dibenzooxepin derivatives, thiotroposin, phthalimide derivatives, flurbiprofen, felbinac, bufexamac, suprofen, 1,4-diphenylpropyl Piperazine derivatives, carxin compounds, chromanol glycosides (2- (α-D-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol), ictamol, indomethacin, kaolin, diphenhydramine hydrochloride, d- Camphor, DL-camphor, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, diphenhydramine hydrochloride, clemastine fumarate, cyproheptadine hydrochloride, hydrochloric acid Lomethazine, piperazine derivatives, α-D-phenylglycoside derivatives, glycyrrhizic acid or its salts and derivatives thereof (α-glycyrrhizic acid, β-glycyrrhizic acid, α-glycyrrhizic acid methyl ester, β-glycyrrhizic acid methyl ester, α-glycyrrhizin Trisodium acid, monopotassium α-glycyrrhizinate, dipotassium α-glycyrrhizinate, monoammonium α-glycyrrhizinate, trisodium β-glycyrrhizinate, monopotassium β-glycyrrhizinate, dipotassium β-glycyrrhizinate, monoammonium β-glycyrrhizinate ), Glycyrrhetinic acid or a salt thereof, and derivatives thereof (α-glycyrrhetinic acid, β-glycyrrhetinic acid, stearyl α-glycyrrhetinate, stearyl β-glycyrrhetinate, pyridoxine α-glycyrrhetinate, Pyridoxine ruretinate, glyceryl α-glycyrrhetinate, glycerin β-glycyrrhetinate, disodium 3-succinyloxyglycyrrhetinate, etc.), mefenamic acid, phenylbutazone, ibuprofen, ketoprofen, allantoin, calcium pantothenate, pantothenyl ethyl ether, etc. Panthenol or salts thereof and derivatives thereof, ε-aminocaproic acid, diclofenac sodium, tranexamic acid or derivatives thereof (trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexane) Carboxylic acid, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-bromobenzyloxycarbonylaminomethyl Cyclohexanecarboxylic acid, trans-4-m-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexane Carboxylic acid, sodium trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylate, ammonium trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylate Trans-4-p-bromobenzyloxycarbonylaminomethyl potassium cyclohexanecarboxylate, trans-4-m-chlorobenzyloxycarbonylaminomethyl Calcium tilcyclohexanecarboxylate, trans-4-p-methoxybenzyloxycarbonylaminomethyl magnesium cyclohexanecarboxylate, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexanecarboxylic acid monoethanolamine, trans-4-t-butyloxy Carbonylaminomethylcyclohexanecarboxylic acid, trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (3, 5-Dimethoxyphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid , Sodium trans-4-t-butyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylate, trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) Calcium cyclohexanecarboxylate, trans-4- (3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) magnesium cyclohexanecarboxylate, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid monoethanolamine, trans -4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarbo Acid, sodium trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylate, potassium trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4- (pyridine-4'-methyl Oxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylate potassium, trans -4- (pyridine-4'-methyloxycarbonylaminomethyl) cyclohexanecarboxylate sodium, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylate potassium, trans-4- (2- Trimethylsilyl Ethoxycarbonylaminomethyl) cyclohexanecarboxylate, etc.), sulfatide, astaxanthin fatty acid diester (astaxanthin dilaurate, astaxanthin dimyristate, astaxanthin dipentadecanoate, astaxanthin dipalmitate, astaxanthin dipalmitoleate, Astaxanthin diheptadecanoic acid ester, astaxanthin dielaidic acid ester, astaxanthin diricinoleic acid ester, astaxanthin petroselinic acid ester, astaxanthin vaccenic acid ester, astaxanthin eleostearic acid ester, astaxanthin punicic acid ester, astaxanthin ricinic acid ester, astaxanthin paris Naphosphate , Astaxanthin gadoric acid ester, astaxanthin 5-eicosenoic acid ester, astaxanthin 5-docosenoic acid ester, astaxanthin cetolic acid ester, astaxanthin erucic acid ester, astaxanthin 5,13-docosadienoic acid ester, astaxanthin ceracholic acid ester, astaxanthin decenoic acid Ester, astaxanthin steric acid ester, astaxanthin dodecenoic acid ester, astaxanthin dioleic acid ester, astaxanthin distearic acid ester, astaxanthin dieicosapentaenoic acid ester, astaxanthin didocosahexaenoic acid ester, astaxanthin dilinolenic acid ester, astaxanthin dilinolenic acid ester, astaxanthin diester Arachidonic acid ester ), Astaxanthin diglycerophosphate (astaxanthin diglycerophosphate, astaxanthin lyserophosphate palmitate, astaxanthin lysephrophosphatidylcholine palmitate, astaxanthin lysephrophosphatidylcholine DHA, astaxanthin lysephrophosphatidylinositol palmitate, astaxanthin Fattidylinositol DHA, astaxanthing lyserophosphatidylinositol linoleic acid, astaxanthing lyserophosphatidylcholine linoleic acid, etc.), steviol glycosides, benzimidazole derivatives (1- (2-ethoxyethyl) -2- [1- (2 -(4- (1- (4,4-Dimethyl-2-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4 -(2- (4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoic acid, ethyl 2- [4- (2- ( 4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanate, 1- (2-ethoxyethyl) -2- [1- ( 2- (4- (1,1-dimethyl-2-hydroxyethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 1- (2-hydroxyethyl) -2- [1- (2- (4- (1- (4,4-Dimethyl-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- ( 4- (1- (2-hydroxyethyl) benzoimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoic acid), alanine derivatives or salts thereof (N- [3-isopentyl- 4-Methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H- Azoline-5-carbonyl] -L-alanine, N- [3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl] -2- Methylalanine, N- [3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl] -N-methyl-L-alanine, etc.) Thiazoline derivative or its salt (3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid, 4-isobutyl-3-methyl-2- [4- (3-trifluoromethylbenzamide) benzoylimino] -3H-thiazoline-5-carboxylic acid, etc.), chlorpheniramine maleate, diphenhydramine hydrochloride, diphenylpyramine hydrochloride, carbinoxamine maleate, hydrocortisone butyrate, sulfated acidic mucos Polysaccharide or salt thereof Sulfated dextran or a salt thereof, fluoromethylhistidine or a hydrochloride thereof, histidine methyl ester or a hydrochloride thereof, licorice extract, sicon extract, age extract, propolis, eye (indigo leaf) extract, asenyaku (asen drug) extract, avocado extract, amadocoro (Tamatake) extract, Amiga lily extract, Baimo (shellfish mother) extract, Igakozorina (ground bile head) extract, Turmeric (Usu gold) extract, Echinashi (Hosobamurasaki Baren Giku) extract, Ouren (Yoren) extract, Oguruma (turnover) ) Extract, Hypericum (Little Cut Grass) Extract, Onigurimi Extract, Orange Extract, Cassia Extract, Chamomile Dessert (Tsumago) Extract, Kawamidori Extract, Kawara Mugwort Extract Kokikekoku extract, ko Uhon (Kakimoto, Karamoto) extract, Koryo Kyo (Kora Kaki) extract, Psycholan extract, Cherry extract, Salvia (sage) extract, Diquitaris extract, Linden extract, Salamander extract, Indobodai extract, Shukushamitsu (Sanjin, Shredded) extract, juzudama extract, white minten (southern berry) extract, oleander extract, sunflower extract, sorghum (milfoyle) extract, broadleaf extract, takasagorihigotai extract, takaharabi extract (Hundred scents) extract, Tasaki tsumugi rafuji extract, Tonin extract, Chigaya extract, Toga (winter coconut) extract, Dokudami (10 medicines) extract, Parsley (Netherlands jelly) extract, Japanese sea bream (Sitoshi, Shishitsuri) extract, Hamasuge (Kanzuke) extract, Hishi (Hishimi) Extract, belude oyster extract, sweet pod extract (south rattan) extract, bundo extract (mung bean) extract, sandalwood extract, butcher bloom extract, pansy extract, red buckthorn extract, mizurutennansho (tennansei) extract, pheasant (fruit) extract , Miracle fruit extract, Munoki extract, Peach (peach) extract, Cornflower extract, Willow willow extract, Mistletoe (willow infestation) extract, Yabukouji (purple gold beef) extract, Sagebrush extract, Mugwort (bamboo leaf) extract, Rosemary (mannenrou) extract , Itohimehagi Extract, Futojuzumo Extract, Tamajuzumo Extract, Mizojuzumo Extract, Urushigusa Extract, Siwahige Extract, Akamok Extract, Togemoku Extract, Akaba Extract, Maruba Akaba Extract, Harigane Extract, Darus Extract, Yuna Extract, Bella Nanna extract, cypress extract, Japanese elm extract (skin, white skin, coconut leaf) extract, Aozzuran extract, Sakaneran extract, Sasabagin orchid extract, Chinese cabbage extract (including varieties and origins), valerian extract, primrose extract, sensu extract , Kyonin extract, honeysuckle extract, Tokyo extract, fennel extract, peppermint extract, and the like.

Anti-seborrheic agent An anti-seborrheic agent can be added to the preparation of the present invention. Specific examples of the antiseborrheic agent include chroman derivatives, pyridoxine or salts thereof and derivatives thereof, pyridoxal or salts thereof and derivatives thereof, pyridoxamine or salts thereof and derivatives thereof, sulfur, Asa extract, (Continuous) extract, Dutch mustard (watercress) extract, valerian extract (valerian root) extract, clematis extract, bear sebacekis, savonso extract, rosewood extract, horse chestnut extract, soybean (soybean) extract, Tokinsenka (marigold) extract, Chinese yam Examples include extract, yam extract, nosen-halen extract, dandelion poppy (sect winter flower, sect winter) extract, yabgarashi extract, giant kelp extract, hijirimen extract, primrose extract, haius banori extract.

Antibacterial agent An antibacterial agent can be added to the preparation of the present invention. Specific examples of antibacterial agents include acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salashi powder , Iodine compounds, iodoform, 1-alkylcarbapenem compounds, N-substituted azepane derivatives or salts thereof, sorbic acid or salts thereof, propionic acid or salts thereof, salicylic acid or salts thereof, dehydroacetic acid, parahydroxybenzoic acid esters, 2 -Keto-3-deoxyoctanoic acid fatty acid esters, inositol deoxy derivatives (such as quercitol), inositol unsaturated derivatives (such as chonditol), inositol dimethyl ether, methyl inositol, inositol methyl ester Ether, inosamine, deoxyinosadiamine, shikimic acid, quinic acid, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol , Thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, Chlorobutanol, isopropylmethylphenol, elemol, vetiverol, patchouli alcohol, nonionic surfactant (polyoxyethylene lauryl ether, polyoxyethylene nonyl pheny Ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, Methylrosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal violet, germal, photosensitive element 101, photosensitive element 201, photosensitive element 401, N-long chain acyl basic amino acid derivatives and acid addition salts thereof, oxidation Zinc, hinokitiol, propolis, cucumber extract, agi (Ayu) extract, asunaro extract, alpinia extract, Inubilu extract (Hagainuinuyu) extract, Aogatetou extract, Haribiyu extract, Ayuyu extract, Hagaitoue Kiss, Hosonagabiyu extract, Enmeiso extract, Warbler mosquito extract, Usba saicin extract, Oshusaishin extract, Halibut extract, Ominaeshi (defeated soy sauce) extract, Kajikazura (Katsufuji potato) extract, Kahoku sansho (蜀椒) extract, chamomile extract, linden extract, red linden extract, yellowfin extract, caraway extract, betel extract, kumazasa extract, cranberry extract, grapefruit extract, celosia (chicken flower, chicken crown) extract, bay bay (laurel tree) Extract, Koushinbara (Monthly Flower) Extract, Copaiba Balsam Extract, Yamazakura Extract, Edhigashi Extract, Miyazakura Extract, Yoshino cherry Extract, Kasumizakura Extract, Kanzakura Extract, Sugar Beet Extract, Shirashina Chestnut Extract, Sikkunshi ( (Mr. Junko) extract, birch extract, cinnamon extract, sorrel extract, dandelion extract, Japanese prunus extract, Japanese mint extract, wild mint extract, grasshopper extract, onion extract, chicory extract, datura Elm extract, Tsuruna extract, Tokon extract, Japanese leek extract, leek extract, peach extract, patchouli extract, Japanese anemone extract, Japanese cypress extract , Pimenta extract, Hirohakinagusaku (Bald eagle) extract, Blackberry extract, Hop extract, Makuri (Marine herb) extract, Magnolia splengeri extract, Mizokakushi (half-sided lotus) extract, Honey beet extract, Murasaki (purple root) extract, Mosouchiku Extract, pokeweed (commercial land) extract, yucca extract, armor rush extract, labe Dar extract, forsythia extract, cinna forsythia extract, bats normata extract, tochaka (yahauzunomata) extract, redwood swordfish extract, anaahusa extract, tiger rush extract, hirohanito rush extract, iroha rush extract, iroge extract, damselfish extract, arame extract , Banbanori extract, katanori extract, cherry blossom extract, Fujimatsumo extract, kawamozuku extract, aokawa mozuku extract, himeka mozuku extract, yakchi (maschi) extract and the like.

Blood flow promoter / vascular stimulator A blood flow promoter / vascular stimulator may be added to the preparation of the present invention. Specific examples of blood flow promoters and vascular stimulants include tocopherol or salts thereof and derivatives thereof, tocotrienol or salts thereof and derivatives thereof, cephalanthin, carpronium chloride, eugenol derivatives (acetyleugenol, methyleugenol, methylisoeugenol, ethyl (Eugenol, ethylisoeugenol, eugenol salicylate, etc.), minoxidil, chili pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, L-menthol, camphor, benzyl nicotinate, cinnarizine, trazoline, acetylcholine, verapamil, ectamol , Α-borneol, cyclandelate, nonyl acid wallenylamide, capsaicin, gingerone, assembly extract, garlic extract, carrot extract , Aloe extract, Gentian extract, Toki extract, Ashitaba (Tomorrow) extract, Arnica extract, Ukiyagara (Sanryo) extract, Himewiku extract, Citrus unshiu (Chest) extract, Toucan beetle (coconut) extract, Oyster extract, Persimmon extract, Kina extract, Goldfish hen extract, Anemone beetle extract, Gubijinsou extract, Kouhone (river bone) extract, Burdock (beef bowl, beef coconut) extract, Sagaki Kyo (Yamabachi) extract, Sinalengyo extract, Ginger extract, Shobu (bamboo shoot, radish) extract, Hawthorn extract, assembly (powdered medicinal) extract, Daidai (orange peel) extract, tanjin (dansang) extract, thyme extract, chiketsu carrot (bamboo ginseng) extract, tsurudokudami (what neck crab) extract , Carrot (Yoteba ginseng) extract, Capsicum (bansho) extract, Toki (toll) , Japanese hornworm extract, Natsumikan extract, elderberry (bone-bone) extract, hazelnut (coconut) extract, Hashiridokoro (roth root) extract, mint (light load, light load) extract, Hamabou Fu (hama wind) extract, Higotai extract , Fujimodoki (Chojizakura, Camellia) extract, Black currant extract, Bodaiju (Aoki tree) extract, Merirot extract, Yuzu extract, Loquat extract, Japanese jelly extract, Hibiscus extract, Rosehip extract and the like.

Antiandrogen Agent An antiandrogen agent can be added to the preparation of the present invention. Specific examples of antiandrogens include follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendrone, 4 ′, 5,7-trihydroxy-8-prenylflavanone, 4 ′, 5,7-trihydroxy-8 -Prenyl flavone, 3,3 ′, 4 ′, 5,7-pentahydroxy-8-prenyl flavone, nicorandil, cyclosporine and the like.

Structural proteolytic enzymes (elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme, etc.) Activity inhibitor / structural protein Decomposition enzyme expression inhibitor The preparation of the present invention includes structural proteolytic enzymes (elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme, etc. Matrix metalloprotease) activity inhibitor / structural protease inhibitor can be added. Specific examples of structural proteinase activity inhibitors / structural proteinase expression inhibitors include adenine derivatives (butanetriol-9-adenine and its phosphate adduct, propanediol-9-adenine and its phosphate adduct, Pentanetriol-9-adenine and its phosphate adducts), carbostyril derivatives or salts thereof, dicarboxylic acids (glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, 1,9-nonamethylenedicarboxylic acid) Acid, 1,10-decamethylenedicarboxylic acid), rosmarinic acid, ursolic acid, oleanolic acid, hydroxamic acid derivative, esculetin derivative, anthocyanidins, nordihydroguaiaretech acid, 20-carboxy-16-hydroxy-21-nor- 5 α-7,9 (11) -lanostadien-3,24-dione, ubiquinone, plastaquinone, yugro , Shikonin, quinizarin, alizarin, abietin, levopimaric acid, betulin, α-amylin, catechin compounds (catechin, epigallocatechin, epigallocatechin gallate, epicatechin, epicatechin gallate, catechin rhamnopyranoside catechin, etc.), fluoro Diisopropyl phosphate, (2R, 6R) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate, N, N'-bis-[( 1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydroxyheptanedicarboxylic acid-1,7-diamide, (2R, 6R) -2, 6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane- Dimethyl 1,7-dicarboxylate, (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyl Tyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy -4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R)- 2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R)- 2,4,6-Trihydroxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2,6 -Dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, (2S, 6S) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7 Dimethyl dicarboxylate, dimethyl (2S, 6S) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate (2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2S, 6S) -2,6-dibenzyloxy- 4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2, 6-Dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-( 2R, 6R) -2,6-Dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, 3-[[4- (4-fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclopentyl) -Amino] -propionic acid, 4- [4- (4-fluorophenoxy) -benzenesulfonylamino] -tetrahydropyran-4-carboxylic acid hydroxyamide, 4- [4- (4-chlorophenoxy) -benzenesulfonylmethyl] -Tetrahydropyran-4-carboxylic acid hydroxyamide, 3-[[4- (4-fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclobutyl) -amino] -propionic acid, 4- (4'-chloro Biphenyl-4-yl) -2- [2- (1,3-dioxo-1,3-dihydroisoindol-2-yl) -ethyl] -4-oxobutyric acid, 1- [4- (4-fluorobenzyl) Oxy) -benzenesulfonyl] -2-hydroxycarbamoylpiperidin-3-yl) -carbamic acid isopropyl ester, 2- [4- (4-fluorophenoxy) -benzenesulfonylamino] -N-hydroxy-2-methylpropionamide, 3- [4- (4-Fluorophenoxy) -benzenesulfonyl] -2, N-dihydroxypropionamide, 3- (4-phenoxybenzenesulfonyl) -7-oxabicyclo [2.2.1] heptane-2-carboxylic acid hydroxy Amide, (4-benzylbenzyl)-[2- (2,2-dimethyl-1-methyl Rubamoylpropylcarbamoyl) -4- (4'-fluorobiphenyl-4-yl) -butyl] -phosphinic acid, 2-amino-3- [4- (4-fluorophenoxy) -benzenesulfonyl] -N-hydroxypropion Amide, N-Hydroxy-2- (4-phenylpiperidine-1-sulfonyl) -acetamide, Iris japonicus extract, Nepenthes (Summer hay) extract, Greater Crape myrtle (Banaba) extract, Large hawthorn extract, Hawthorn (Yamako) extract, Calahoo (Park) extract, guava extract, trash (Gomiko) extract, papaver extract, rose rose extract, Hypericum perforatum extract, chickweed extract , American Grape Extract, European Grape Extract, Yama Grape Extract, Mandarin Extract, Mishima Psycho (Shibahu) Extract, Ou Gon extract, Hypericum extract, Clara extract, Mulberry extract, Keihi extract, Gentian extract, Comfrey extract, Salvia extract, Elderberry extract, Body squirrel extract, Button pi extract, Aos zulan extract, Sakaneran extract, Sasabagin orchid extract, Chinese cabbage extract (variety and origin) (Including seeds) extract, red-green agave extract, sisal extract, garlic extract, and the like.

Structural protein synthesis promoter A structural protein synthesis promoter can be added to the preparation of the present invention. Specific examples of structural protein synthesis promoters include ethanolamine derivatives, pentoxyphyllin, serine derivatives, geraniol, crocetin, methyl 4- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-4- (3, 5,5-Trimethylhexyloxy) methyl benzoate, methyl 4-cyclohexylmethoxy-2-hydroxybenzoate, methyl 4- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4- (3,7-dimethyl-6 -Octenyloxy) methyl 2-hydroxybenzoate, ethyl 3- (2-ethylhexyloxy) -5-hydroxybenzoate, methyl 5- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-5 -(3,5,5-trimethylhexyloxy) methyl benzoate, methyl 5- (2-cyclohexylethoxy) -2-hydroxybenzoate, methyl 4-N-hexyloxy-2-hydroxybenzoate, 2-hydride Methyl xyl-4-N-octyloxybenzoate, methyl 4-N-decyloxy-2-hydroxybenzoate, methyl 5-N-hexyloxy-2-hydroxybenzoate, 4- (2-ethylhexyloxy) -2- Hydroxybenzoic acid, 2-hydroxy-4- (2,5,5-trimethylhexyloxy) benzoic acid, 4-cyclohexylmethoxy-2-hydroxybenzoic acid, 4- (2-cyclohexylethoxy) -2-hydroxybenzoic acid, 4- (3,7-dimethyl-6-octenyloxy) -2-hydroxybenzoic acid, 3- (2-ethylhexyloxy) -5-hydroxybenzoic acid, 5- (2-ethylhexyloxy) -2-hydroxybenzoic acid Acid, 5- (2-ethylhexyloxy) -2-hydroxybenzoic acid, 2-hydroxy-5- (3,5,5-trimethylhexyloxy) benzoic acid, 5- (2-cyclohexylethoxy) -2-hydroxybenzoic acid Acid, 4-N-hexyloxy-2-hydroxybenzoic acid, 5-N-hexyloxy-2 -Hydroxybenzoic acid, 2-hydroxy-4-N-octyloxybenzoic acid, 4-N-decyloxy-2-hydroxybenzoic acid, N- (2-hydroxyethyl) -4- (2-ethylhexyloxy) -2- Hydroxybenzamide, N-ethyl-4- (2-ethylhexyloxy) -2-hydroxybenzamide, 2-acetoxy-4-cyclohexylmethoxybenzoic acid, 4- (2-ethylhexyloxy) -2-hydroxybenzoic acid sodium, 4- [(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoate methyl, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] Ethyl-2-hydroxybenzoate, 5-[(2E) -3,7 dimethyl-2,6-octadienyloxy] -2-hydroxyethyl benzoate, 3-[(2E) -3,7-dimethyl- Ethyl 2,6-octadienyloxy] -2-hydroxybenzoate, ethyl 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -5-hydroxybenzoate, 4- [(2E) -3,7-dimethyl-2,6-octadienyloxy] -3-methoxybenzoate, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10 -Dodecatrienyloxy] -2-hydroxybenzoic acid methyl, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid (2E) -3,7- Dimethyl-2,6-octadienyl, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid, 5-[(2E) -3,7-dimethyl- 2,6-octadienyloxy] -2-hydroxybenzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid, 3-[(2E ) -3,7-dimethyl-2,6-octadienyloxy] -5-hydroxybenzoic acid, 2-hydroxy-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10 -Dodecatrienyloxy] benzoic acid, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -3-methoxybenzoic acid, 2-acetoxy-4-[(2E) -3 , 7-Dimethyl-2,6-octadienyloxy ] Benzoic acid, N- (2-hydroxyethyl) -4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzamide, 4-[(2E) -3, 7-dimethyl-2,6-octadienylamino] -2-hydroxybenzoic acid, dimethyl-2,6-octadienyloxybenzoic acid, N- (2-hydroxyethyl) -4-[(2E) -3 , 7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienylamino] -2-hydroxybenzoic acid, 3 -Dodecyloxybenzoic acid, 3- (12-hydroxydodecyloxy) benzoic acid, 4-dodecyloxybenzoic acid, 4- (12-hydroxydodecyloxy) benzoic acid, 3- (12-hydroxyoctadecyloxy) benzoic acid, 4 -(12-hydroxyoctadecyloxy) benzoic acid, 3- (11-hydroxyundecyloxy) benzoic acid, 4- (11-hydroxyundecyloxy) benzoic acid, 3-[(2E) -3,7-dimethyl- 2,6- Tadienyloxy] benzoic acid, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, 3-[(2E, 6E) -3,7,11-trimethyl-2,6 , 10-dodecatrienyloxy] benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4- [3,7-dimethyl -9- (2,6,6-trimethyl-1-cyclohexen-1-yl) -2,4,6,8-nonatetraenyloxy] benzoic acid, 4- [3,4-dihydro-2,5, 7,8-Tetramethyl-2- (4,8,12-trimethyltridecyl) -2H-1-benzopyran-6-oxy] benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl -2,6,10-dodecatrienyloxy] benzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzamide, 4- (2-methyl-2-butenyloxy) benzamide 4- (2-ethylhexyloxy) benzamide, 4-dodecyloxybenzamide, 4- (12-hydroxydodecyloxy) benzamide, 4- (12-hydroxyoxy) Tadecyloxy) benzamide, 4- (11-hydroxyundecyloxy) benzamide, 4- (10-hydroxydecyloxy) benzamide, 4-isostearyloxybenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E ) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzamide, N, N-dimethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6, 10-dodecatrienyloxy] benzamide, N, N-di [(2E) -3,7-dimethyl-2,6-octadienyl] -4-aminobenzamide, 4- [N'-methoxycarbonyl-N-[( 2E) -3,7-dimethyl-2,6-octadienylamino] benzamide, 4- [N-acetyl-N-[(2E) -3,7-dimethyl-2,6-octadienyl]] aminobenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, N, N-diethyl-4 -[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyl Xy] -2-hydroxybenzamide, pea extract, red pepper extract, scots reed extract, hosobonori extract, bonito extract, igisu extract, keigi extract, harii squirrel extract, honey beet extract, euglena extract, moly rush extract, Willow extract, Willow extract, Motuyurena extract, Venetian extract, Moth willow extract, Sabaya willow extract, Wasabi extract, Merbow extract and the like.

Mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitor A mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitor can be added to the preparation of the present invention. Specific examples of mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitors include anacardic acid or its derivatives (6-pentadecatrienylsalicylic acid methyl ether, 6-pentadecatrienylsalicylic acid ethyl ether, 6-pentadecaic acid). Trienyl salicylic acid propyl ether, 6-pentadecatrienyl salicylic acid butyl ether, 6-pentadecatrienyl salicyl alcohol methyl ether, 6-pentadecatrienyl salicyl alcohol ethyl ether, 6-pentadecatrienyl salicyl alcohol propyl ether, 6- Pentadecatrienyl salicyl alcohol butyl ether, 6-pentadecatrienyl salicylaldehyde methyl ether, 6-pentadecatrienyl salicylaldehyde ethyl ether, 6-pentadecatrienyl salicylaldehyde Propyl ether, 6-pentadecatrienyl salicylaldehyde butyl ether, 2-methyl ether-6-pentadecatrienyl cinnamic acid, 2-ethyl ether-6-pentadecatrienyl cinnamic acid, 2-propyl ether-6- Pentadecatrienyl cinnamate, 2-butyl ether-6-pentadecatrienyl cinnamate, 2-methyl ether-6-pentadecatrienyl cinnamate alcohol, 2-ethyl ether-6-pentadecatrienyl cinnamate Alcohol, 2-propyl ether-6-pentadecatrienyl cinnamic alcohol, 2-butyl ether-6-pentadecatrienyl] cinnamic alcohol, etc.), polyisoprenylated benzophenone derivatives (garcinol, isogarcinol, xanthothymol) , Isoxanthothymol, gucciferon, etc.), Ikarisou extract, Yachima Taikiso (Inyo) (October) extract, Narco lily extract, Occidental lily (Yellow spirit) extract, Oregano extract, Oshida extract, Onji extract, Spruce extract, Crow birch extract (half-summer) extract, Pheasant extract Skin) extract, goshyu extract, senega extract, sendan extract, tamarind extract, tarragon extract, ginkgo biloba extract, bee extract, daisy extract, mirabaran extract, himebara extract, Mockin Extract, Laurel Extract, Yabusotatsu Extract, Anaaaosa Extract, Macrocystis Integrifolia Extract, Neocitus Ruetkeana Extract, Nettle Extract, Prunus Extract, Kata-Bucka Extract, Yatabegusa Extract, Shimatengusa Extract, Ezotsunomata Kisses, Swallowtail extract, Fusiwa ivy extract, Hanemo extract, Mill extract, Chromel extract, Nagamil extract, Hiramil extract, Matsumo extract, Okinawa mozuku extract, Mozuku extract, Fukuronori extract, Kajime extract, Orochi nori extract, Mafnori extract, Grape leaf extract, Salamander extract, Astragalus extract etc. are mentioned.

Mucopolysaccharide synthesis promoter A mucopolysaccharide synthesis promoter can be added to the preparation of the present invention. Specific examples of the mucopolysaccharide synthesis accelerator include stilbene derivatives or salts thereof, morgin or salts thereof and derivatives thereof, N-acetylglucosamine, flax extract, cinnamon extract, mulberry extract, scotch extract, breadfruit extract, hirakotoji extract , Kotojitsu no Mata Extract, Yaleus Banori Extract, Kagiosu Banori Extract, Susius Banori Extract, Amiaosa Extract, Nagaaosa Extract, Hosobanosakamodoki Extract, Hirohatosakamodoki Extract, Yatsudegatatosakamodoki Extract, Kurotosakamodoki Examples include extract, Nezushinosakamodoki extract, Yusora extract, Etsukinotosakamodoki extract, Nankaitosakamodoki extract, Himetosakamodoki extract, and the like.

Intercellular lipid production promoter / intercellular lipid state improver An intercellular lipid production promoter / intercellular lipid state improver can be added to the preparation of the present invention. Specific examples of intercellular adipogenesis promoters and intercellular lipid state improvers include phospholipids (phosphatidylethanol, phosphatidylcholine, phosphatidyltriethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylglycerin, phosphatidylinositol, diacylphosphatidylcholine, diacylphosphatidylethanol Amine, diacylphosphatidylinositol, diacylphosphatidylserine, 1-cysteinylphosphatidic acid, 2-cysteinylphosphatidic acid, 1-glutathionylphosphatidic acid, 2-glutathionylphosphatidic acid, 1-azelaoylphosphatidic acid, 2- Azela oil phosphatidic acid, 1-hydroxyacyl phosphatidic acid, 2-hydroxyacyl phosphatidic acid, ceramide, glucosyl Lamide, galactosylceramide, cerebroside, phosphatidylglucosylacylglycerol, N-oleoylsphingosine, N- (12-hydroxyoctadecanoyl) sphingosine, N- (16-hydroxyhexadecanoyl) sphingosine, N-salicyloylphytosphingosine, Sphingomyelin, soybean lecithin, egg yolk lecithin, etc.), sterins (cholesterol, dihydrocholesterol, cholesteryl stearate, cholesteryl hydroxystearate, macadamia nut oil fatty acid cholesteryl, β-sitosterol, stigmasterol, campesterol, ergosterol, 5-dihydro Ergosterol, phytosterol, 25-hydroxycholesterol, 26-hydroxycholesterol, 19-hydroxycholesterol, 22-ketocholes Roll oxime, 6-ketocholesterol and 7-ketocholesterol or their derivatives), N-acetylneuraminic acid (sialic acid), N-glucosolneuraminic acid, gangliosides (gangliotriose, gangliotetraose , Globotetraose, neolactotetraose, neolactohexaose, neolactooctaose, etc.), oligosulfated hyaluronic acid, hydroxytamoxifen compounds, glyceroglycolipids, pentoxyphyllin, 3-deazaadenosine, carboxamide derivatives, Inositol polyamines, sialic acid, triterpenic acid derivatives, lactose, lactosamine derivatives, sulfated chitin derivatives, albumin, ginseng extract, tochiban ginseng extract, sea cucumber extract, red lily extract, green lily extract, chickweed extract And the like.

Keratin solubilizer and stratum corneum peeling promoter A keratolytic agent and stratum corneum peeling accelerator can be added to the preparation of the present invention. Specific examples of keratolytic agents and stratum corneum exfoliation promoters include tropolone and its derivatives, resorcin, lactic acid, urea, salicylic acid, guanidine, ethanolamine, fenugreek extract, peanut extract, lentil extract, chickpea extract, mungbean extract, etc. It is done.

Plasminogen activator antagonist inhibitor A plasminogen activator antagonist inhibitor can be added to the preparation of the present invention. Specific examples of the plasminogen activator antagonist inhibitor include rabbit daisy extract, canamgra extract, caladium extract, raspberry extract and the like.

Maillard reaction inhibitor A Maillard reaction inhibitor can be added to the preparation of the present invention. Specific examples of Maillard reaction inhibitors include aminoguanidine, flavanones (naringin, naringenin, liquiritin, liquiritigenin, digallic acid, luteoic acid, ellagic acid, chlorogenic acid, glucogallin, tetralin, hamamelitannin, gallic tannin, tannic acid, (Geraniin, gallic acid, galloyl gallic acid, ellagitannin, hexagalloyl glucose, heptagalloyl glucose, tetragalloyl glucose, triggerroyl glucose, pentagalloyl glucose, digalloyl quinic acid, triggerroyl quinic acid), 2-hydroxyphenylalkylamine Derivatives or salts thereof, phenylpropenoic acid derivatives (3- [2,3-bis (methoxymethoxy) phenyl] propenoic acid, 7- (4-hydroxy-3-methoxyphenyl) hepta-2,4,6-trienoic acid, 3- (3,5-Dimethoxy-4-hydroxy (Roxyphenyl) propenohydrazide, N'-isopropylidene-3- (2-methoxyphenyl) propenohydrazide, etc.), citric acid or its salts, gypsum extract, sandalwood extract, red clover extract, persimmon (柿) (Including moths) Examples include Tarayo extract, Dokudami extract, Tormentilla extract, Bakumondo extract, Hiba extract, Grape extract, Japanese willow extract, Mukuroji extract, Karin extract, Mokka extract, Roman chamomile extract and the like.

Testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promoter A testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promoter can be added to the preparation of the present invention. Specific examples of testosterone 5α reductase activity inhibitor, hair papilla activator and hair growth promoter include γ-amino-β-hydroxybutyric acid esters (γ-amino-β-hydroxybutyric acid methyl ester, γ-amino-β- Hydroxybutyric acid ethyl ester, γ-amino-β-hydroxybutyric acid propyl ester, γ-amino-β-hydroxybutyric acid butyl ester, γ-amino-β-hydroxybutyric acid ethylhexyl ester, γ-amino-β-hydroxybutyric acid hexadecyl ester, γ-amino-β-hydroxybutyric acid lauryl ester, γ-amino-β-hydroxybutyric acid stearyl ester, γ-amino-β-hydroxybutyric acid oleyl ester, γ-amino-β-hydroxybutyric acid benzyl ester, γ-amino-β- Hydroxybutyric acid phenyl ester, γ-amino-β-hydroxybutyric acid ethyl glycol ester, γ-amino-β-hydroxy Acid sorbitol ester, γ-amino-β-hydroxybutyric acid polyoxyethylene glycol ester, γ-amino-β-hydroxybutyric acid glycerin ester, etc.), amine oxides (oleyl dimethylamine oxide, stearyl dimethylamine oxide, palmityl dimethylamine oxide) , Myristyl dimethylamine oxide, lauryl dimethylamine oxide, dimethyl lauryl ethoxyamine oxide, dihydroxyethyl lauryl amine oxide, coconut oil alkyl dimethylamine oxide, etc.), alkyl betaines (coconut oil fatty acid amidopropyl betaine, coconut oil alkyl betaine, lauryl dimethyl) Aminoacetic acid betaine, lauric acid amidopropyl betaine, lauryl hydroxysulfobetaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl Imidazolinium betaine), pyrimidine-N-oxide derivatives (2-amino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-6- (1-pyrrolidinyl) pyrimidine- 3-oxide, 2-amino-4-methyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-6- [1- (4-methylpiperazinyl)] pyrimidine-3-oxide, 2-amino-4- (1-hexahydroazepinyl) -6-methylpyrimidine-1-oxide, 2-amino-4-dimethylamino-6-methylpyrimidine-1-oxide, 2-amino-4-allylamino -6-methylpyrimidine-1-oxide, 2-amino-4-benzylamino-6-methylpyrimidine-1-oxide, 2-amino-4,5-methyl-6-piperidinopyrimidine-3-oxide, 2 -Amino-4-ethyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-5-nitro-6-piperidinopyrimidine-3-oxide, 2,5-diamino- 4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-5-piperidino -6- (1-pyrrolidinyl) pyrimidine-3-oxide, 2-methyl-4-amino-6-piperidinopyrimidine-3-oxide, 2-methyl-4-amino-5-bromo-6- (1- Pyrrolidinyl) pyrimidine-3-oxide, 2-methyl-4-amino-5-nitro-6-piperidinopyrimidine-3-oxide, 2-methyl-4,5-diamino-6-piperidinopyrimidine-3- Oxide, 2-methyl-4-amino-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-6-piperidinopyrimidine-3-oxide monohydrochloride, 2- Acetylamino-4-methyl-6-piperidinopyrimidine-3-oxide, 2,4-diamino-6-phenoxypyrimidine-3-oxide, 2,4-diamino-6- (2,4-dichlorophenoxy) pyrimidine -3-oxide, 2,4- Amino-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitroso-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4- Diamino-5-nitro-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4,5-triamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-bromo-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, etc. ), P-menthane-3,8-diol, monoglyceryl-D-glucoside monotridecanoate, 1-oN-pentadecylglycero-D-glucoside, monopentadecanoic acid glyceride sulfate, etc. -Monopentadecyl glyceryl ether sulfate, 1-o-hexadecyl-2-o-methylglycerin, 1-o-octadecyl-2-o-me Luglycerin, 1-o-oleyl-2-o-methylglycerin, acetylcarnitine or its salt, geranylgeranylacetone, hydroxamic acid derivative or its salt, gingerone glycoside, benzeneoxyacetic acid derivative ([5- [2- [1 -Phenyl-1- (3-pyridyl) methylideneaminooxy] ethyl] -7,8-dihydronaphthalen-1-yloxy] acetic acid), isorhamnetin-3-robinobioside, xanthone derivatives, proanthocyanidins (grape seed extract) Proanthocyanidins, apple-derived proanthocyanidins, pine-derived proanthocyanidins, purified procyanidin oligomers, procyanidin B-1, procyanidin B-2, procyanidin B-3, procyanidin C-1), aracaci extract, angelica extract, apricot extract , Hong anzu extract, Ichiyakuso (one herb) extract, Enishiidae Kiss, plantain (carrot, carp grass) extract, papaya chabushi extract, olive extract, giant pufferfish extract, seisei extract, calla extract, chrysanthemum extract, chrysanthemum extract, chrysanthemum extract, kukui nut extract, camphor extract, Kubeba extract, Chrysanthemum extract, Snapper extract, Snapdragon extract, Snapdragon extract, Kippi extract, Japanese beetle extract, Cilantro extract, Kobushi extract, magnolia extract Rango extract, sasanqua extract, sweet potato extract, sanebuto jujube (acid soy sauce) extract, sanzukon (yamazu-root) extract, potato extract, shishigashira extract, sanshishi Kiss, coriander extract, stevia extract, Takatodai extract (Otsuka) extract, Tarayou (Oba Fuyu-blue, Ichiha tea, bitter tea, Tofu tea) extract, Taranoki extract, Nigaki (Nakiki) extract, Nurde (penta) extract, Hakama Urabosi (bone crush) extract, spider magnolia extract, scented squirrel extract, stag beetle extract, sorghum grass extract, citron ginseng (participant) extract, mangosteen extract, myouga extract, melaroika extract, yachabushi extract, himeya sabushi extract, oba Examples include Yachabushi extract, Yakumosou extract, Yamahanoki (Yamatake) extract, Longan (long-eye) extract, Lokon (Yoshi, Sone) extract, Logwood extract, Lantana extract and the like.

Hair matrix growth inhibitor / hair growth inhibitor A hair matrix growth inhibitor / hair growth inhibitor can be added to the preparation of the present invention. Specific examples of hair matrix growth inhibitor / hair growth inhibitor include phthalazinones, benzoxazinones, phosphonic acid derivatives, cyproterone, 5α-androstene-3α, 17β-diol, medroxyprogesterone, norethisterone, methanolone, and ichihatsu (First) extract, citrus extract, kanto extract, sanjiko extract, silamo extract, sardine extract, scabbard fern extract, fritillary extract, honeysuckle extract, seaweed extract, oleander extract and the like.

Hair swelling agent / hair protecting agent A hair swelling agent / hair protecting agent can be added to the preparation of the present invention. Specific examples of the hair swelling agent / hair protecting agent include ethanolamine, urea, guanidine, silicones, blueberry extract, mango extract and the like.

Odorous substance eliminating agent An odorous substance eliminating agent can be added to the preparation of the present invention. Specific examples of the odorous substance eliminating agent include Inondo extract, Elemi extract, vanilla bins extract, pine extract and the like.

Other Additive Ingredients Specific examples of ingredients derived from plant-based materials used as additives to the formulation of the present invention include Aokazura (Seifuto) extract, Aotenma extract, Akasuguri extract, Aquine (crustacean) extract, Aguay Guasu extract, Abiu extract, Abiurana extract, Yellow sapote extract, Ylang ylang extract, Uranium orchid extract, Uba tea extract, Ezo lily extract, Eun Boku extract, Elderberry extract, Prunus extract Extract, Onoelan extract, Crab extract (Kinshato) extract, Karaya extract, Garyu extract, Kawaratake extract, Candelilla extract, Canna extract, Kidachi pepper extract, Kimenkaku extract, Cave extract, Kiraja saponaria extract, Ginsekai Kiss, Kimbusen Extract, Guapeba Vermela Extract, Kugenuma Maran Extract, Gooseberry Extract, Curitiba River Extract, Curkurigo Latifolia Extract, Black Ganechi (Rescuer) Extract, Kourian Extract, Sapotea Marillo Extract, Salmon Berry Extract, Salamander Extract , Cactus Cactus Extract, Cranberry Extract, Shunran Extract, Shozuk Extract, Shirobanatsuta Extract, Cinchona Sacylbra Extract, Swimberry Extract, Star Apple Extract, Sulgaran Extract Japanese butterfly extract, mistletoe extract, sennin cactus extract, senboku extract, elephant weevil extract, cinnamon wax extract, potato mono potato extract, da Couture Cherry Extract, Prickly Pear Extract, Choco Stay Stay Extract, Korean Artemisia Extract, Tsukushi Saka Neran Extract, Tsuchiakebibi Extract, Duckweed (Duckweed) Extract, Duberry Extract, Spruce Extract, Tragacanth Extract, Triacanthus Extract , Neiseria berry extract, Rapeseed extract, Plover-dough extract, Pau doce extract, Hakuru berry extract, Batata extract, Hamakakiran extract, Balata extract, Harcan orchid extract, Pecan nut extract, Hinori duck extract, Himemuyoran extract, Brazil Carrot extract, Branjen extract, Frucereria extract, Blond psyllium extract, Hetsukaran extract, Heneken extract, Berry extract, Persair extract, Pervianburg extract, Pereschia gura Ndofria extract, Boysenberry extract, Hausairan extract, Pouteria sapota extract, Pouteria rukuma extract, Hosobabarengiku extract, White berry extract, Masaransuba extract, Masheira de Boyi extract, Matta auryo extract, Mulberry extract, Midori Sapote extract, purple corn extract, megacansa opuntica extract, mokukirin extract, Japanese maple extract, Morero cherry extract, Yakawa purple potato extract, cornflower extract, Ruritama thisami (Vultures), red currant extract, red pitaya Examples include plant extracts such as extract, lemongrass extract, wax palm extract, and logan berry extract.

  In addition, as specific examples of components derived from plant-based raw materials used as an additive to the preparation of the present invention, Dunaliella genus Dunaliella extract, Kuwanomi genus Kuwanomimo extract, Volbox genus genus sunflower extract, Volbox genus Volbox extract, Palmera extract, Yotsumemo extract, Aomydra spp. , Pseudomonas genus black extract, Casanori genus extract, Mika Kaki extract, Collecaete extract, Budworm extract, Kryocera genus Duckweed extract, Sayamidro extract, Kunsho Extracts, green algae extracts such as Sumiremo violet, Hosimidro extract, Fuchinashimidoru extract, cyanobacteria suizengenori extract, blue-green algae extract such as Aoko extract, Yulemo extract, Piraella pirea extract, Shiamidomo Nagamisiomidro extract, Isovine genus isovine extract , Isogawala genus Isogawara extract, Black moth genus Black moth moth extract, Kashirazaki genus Kashirazaki essence, Muchimo genus Muchimo extract, Muchimo genus Hiramachimo extract, Muchimo genus Quercus crisposa extract, Amygusa genus Sakibiro amiji extract, Common genus genus Common genus extract, Jigamigusa genus digigagus Nami-makura genus Hirami-makura extract, Someraceae genus Someraceae extract, Navarimo genus Navarimo extract, Chasomen genus Mocha-chaumen extract, Ganoderma spp. Genus Composita extract, genus Camellia spp. Nori extract, genus Cyprus extract, genus genus genus extract, turmeric genus extract, genus chrome extract, chrysanthemum Brown algae extract such as Ishicombu genus Chrysanthemum extract, Uchimo spp. Milnobeni extract, Konahada spp. Sodegarami Sodegarami Extract, Hirohatamitaki Hirohatamitaki Extract, Tengusa Nambugusa Extract, Tengusa Kohira Extract, Tengusa Yohira Extract, Tengusa Kinukusa Kiss, Hibiro hibishiro extract, Hibiro hibishiro extract, Isomume genus Isommedo extract, Echinodera genus Extract, Ryumon genus Ryumon extract, Ryumon genus Hera ryumon extract, Niseka genus extract , Okitsubara Okibutsubara Extract, Sangomoda Ragarodoku Extract, Shiogusagoromo Shiogusagoromo Extract, Iwanokawa Etsukiiwakawa Extract, Kainokawa Kainokawa Extract, Kaninote Kaninote Extract, Sangomo Sangomo Extract Genus Hiram Cadet Extract, Centipede Genus Kyoko Spider Extract, Centipede genus Centipede Extract, Centipede Gentle Extract, Centipede Fudarak Extract, Mu Denori spp. Genus centipede extract, Kintoki genus Nagakintoki extract, Kintoki sp. Tsukasanoori Hanagakarimenia extract, Honoho genus Hounoo extract, Hikagenoito genus genus extract, Hikagenoit genus Usuginu extract, Kuwano spp., Venetian spp. Mizoogonori extract, Ogonori genus Beniogonori extract, Ogonori sp. Ogonori genus Ogonori extract, Ogonori genus tsutsuginu extract, Ogonori genus Ogonori extract, Ogonori Kubireogonori extract, Ogonori mosasagonori extract, Ogo Nori Kinubanori Extract, Namiiwatake Namiiwatake Extract, Saimi Italiasa Extract, Saimi Saimi Extract, Lotus Jigusa Lotus Jigsusa Extract, Black Haginnosa Black Haginnang Extract, Hishibukuro Hishibukuro Extract, Madaragus Togemadara Extract Extract Extract, Weibusa spp., Buffalo genus Benifu cranori extract, Vaccinium spruce extract, Ventura spp. , Egonori Egonori Extract, Egonori Futogigi Extract, Saeda Saeda Extract, Chilli Momiji Chilli Momiji Extract, Habutaenori Extract, Shirano Kori Extract, Suzushironori Extract, Usbeni Uusbeni Extract, Hasujiginu Hasujiginu Extract, Nagakonoha Nori Naga Extract , Sugiginus genus Sugiginu extract, Sugiginu genus Abususu gininu extract, Heius banori Kagious banori extract, Heius banori genus Yaleus banori extract, haius banori genus suus banori extract, haius banori genus euus banus extract, Ayanishiki Ayanishiki Extract, Ayaginu Ayaginu Extract, Dadia Enasidadia Extract, Shimadadia Isohagi Extract, Shimadadia Shimadadia Extract, Dazimod Genus damselfly extract, maca genus macaque extract, caterpillar genus extract, coral genus extract Odoshi extract, Hyodosig genus Hyodosigusa extract, Hyodosig genus Usubahiodori extract, Isomegusa genus Isomegusa extract, Suzyna genus Sugenashigusa extract, Isobasho genus Isobasho extract, Ideyugogome genus Yukogome extract, Ochimomoku genus Okijimoku Red algae extract such as genus Chisuginori extract, Shajikumo extract, Shirahamamo extract, Hoshitsurimo Hoshitsurimo extract, Rikunotumusu extract, Flasks Examples thereof include axle algae extracts such as peach extract, chaboflask extract and tripella extract, and yellow algae extracts such as Hikarimo Hikarimo extract.

  Specific examples of ingredients derived from animal materials used as an additive to the preparation of the present invention include chicken crown extract, cow, pig or human placenta extract, pig or cow stomach, duodenum, intestine, spleen extract or decomposition products thereof , Bovine or porcine brain tissue extract, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolysate, elastin, elastin hydrolysate, water-soluble elastin derivative, keratin and its degradation product or derivatives thereof, silk Proteins and degradation products thereof or derivatives thereof, porcine or bovine blood cell protein degradation products (globin peptides), cattle or porcine hemoglobin degradation products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and degradation thereof Products or derivatives thereof, skim milk powder and degradation products thereof or derivatives thereof, lactoferrin or degradation products thereof, egg components, fish meat Examples include degradation products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid), and the like.

  Specific examples of components derived from microbial raw materials used as additives to the preparation of the present invention include yeast metabolites, yeast extract, bacterial metabolites, bacterial extract, metabolites such as fungi or mushrooms, actinomycetes metabolites , Extracts such as mold or mushroom, actinomycetes extract, natto metabolite, natto extract, rice fermented extract, rice bran (red rice bran, birch) fermented extract, euglena extract or a decomposed product thereof or water-soluble derivatives thereof, raw milk Or the lactic acid fermented product of skim milk powder etc. are mentioned.

  As the plant, animal, or microbial raw material, any site, cell, tissue, organ, metabolite, etc. derived from a transgenic or cell fusion can be used. Furthermore, it can be obtained by culturing cells of any site, cell, tissue, organ, etc., for example, cultured cells derived from each tissue (cultures derived from animals such as fibroblasts, Langerhans cells, macrophages, epidermal cells, hepatocytes, etc.) Cells, etc.), undifferentiated cells, cells in the middle of differentiation, metabolites thereof, and the like can also be used.

  Specific examples of the ingredients of the natural product raw materials used as additives include seawater such as deep sea water, for example, sea salt, dried sea water, dead sea or Atlantic or Pacific sea water (sodium chloride, chloride). Magnesium, potassium chloride, etc.), sea mud or mud (Fango), for example, sea mud or mud in various places such as Italian Fango, German Fango, Eifel Fango, Freiburg Fango (Containing components: silicon dioxide, titanium dioxide, aluminum oxide, Iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone Natural smectite, bentonite, hectorite and the like.

  Extracts derived from plant raw materials, animal raw materials, microbial raw materials, and other natural product raw materials used as additives are processed in a conventional manner according to the product type and form to be added (for example, pulverization, milling, Treatment, extraction, decomposition, fermentation or metabolic conversion by microorganisms, fractionation, purification, pressing, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. ) And any one of various materials may be selected for use.

  The solvent used for the extraction may be selected in consideration of the intended purpose and type of the product to be provided, or the processing performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isopropanol are used. Lower alcohol such as butanol or hydrous lower alcohol, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1, 3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, 1,2-hexanediol, 1,5-hexanediol, 1,6-hexanediol, pentylene glycol, hexylene glycol, Polyhydric alcohols such as glycerin and polyethylene glycol (molecular weight 100 to 100,000) or hydrous polyhydric alcohols, alcohols , Ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, carbon tetrachloride, phenol, toluene, and other organic solvents, and acids prepared with appropriate normality (hydrochloric acid, sulfuric acid, It is desirable to use one or a mixture of two or more selected from nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.). However, when it is not preferable to contain a solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it may be used alone or in any mixture with water. It may be extracted after squeezing.

  Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. The temperature of the solvent can be arbitrarily set in the range of −4 ° C. to 100 ° C., but is preferably around 10 to 40 ° C. from the viewpoint of the stability of the components contained in the raw material. Further, the weight ratio of the solvent to the raw material can be arbitrarily set within the range of, for example, raw material: solvent 4: 1 to 1: 100, and a weight ratio of 1: 1 to 1:10 is particularly preferable.

  Decomposition mainly includes acid decomposition, alkali decomposition, enzyme decomposition, and high-temperature and high-pressure decomposition. In the decomposition with an acid, for example, it is preferable to use an inorganic acid or an organic acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, oxalic acid, hydrogen bromide, perchloric acid, and periodic acid. In the decomposition by alkali, for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, barium hydroxide, sodium carbonate, ammonium carbonate, calcium carbonate, magnesium hydroxide, sodium silicate, etc. are preferably used. In the decomposition with acid or alkali, the concentration, reaction time, reaction temperature, and the like can be arbitrarily set for the target raw material. In the enzymatic degradation, it is preferable to use an enzyme having a function of degrading proteins, polysaccharides, lipids or complexes thereof having an important function particularly with respect to cell structure, tissue structure, etc., for example, aminopeptidase, dipeptidase, dipeptide Peptidyl peptidase, tripeptidyl peptidase, carboxypeptidase, serine protease, trypsin, chymotrypsin, cysteine protease, thiol protease, papain, aspartate endopeptidase, metalloendopeptidase, bromelain, thermolysin, pronase, pepsin, rennin, pan Proteolytic enzymes (proteases) such as creatine, chymopapain, ficin, collagenase, elastase, amylase, takaamylase, cellulase, hemicellular Polysaccharide-degrading enzymes such as pectinase, polygalacturonase, dextranase, planarase, chicken egg white lysozyme, human lysozyme, papaya lysozyme, turnip lysozyme, barley lysozyme, zymolyce, lysozyme chloride, glucanase, chitinase, etc. Cell wall lytic enzyme. In the degradation with an enzyme, the concentration, reaction time, reaction temperature, pH of the solution, etc. can be set arbitrarily, but it is particularly preferable to set the optimum value for the enzyme used.

  Fermentation or metabolic conversion by microorganisms can be performed by inoculating and growing at least one kind of microorganism on a raw material used as a substrate. Inoculation of microorganisms to the substrate can be done by adding microorganisms directly into the substrate, or by adsorbing them on a carrier such as alginic acid, polyvinyl, gelatin, etc., for example, in the form of fine beads composed of microorganisms and carrier. Further, it can be used by being fixed to the tube wall of the bioreactor. Fermentation or metabolic conversion by microorganisms is not particularly defined as a microorganism to be used, but can generally be defined as microorganisms other than pathogenic microorganisms that exhibit significant toxicity to living bodies. Examples of microorganisms to be used include microorganisms classified into yeasts: Aciculoconidium, Actonia, Aessosporon, Ambrosiozyma, Anthomyces, Apiotrichum, Arthroascus, Arxula, Ashbia, Ashbya, Asporomyces, Atelosaccharomyces Genus, Azymoprocandida, Babjevia, Ballistosporomyces, Bensingtonia, Blastobotrys, Blastodendrion, Blastoderma, Blastoschizomyces, Botryoascus, Botryozyma, Brettanomyces, Brettanomyces bruno, Cullus Genus (Candida albicans, Candida amylolenta, Candida anomala, Candida boidinii, Candida entomaea, Candida etchellsii, Candida famata, Candida fermentati, Candida guilliermondii, Candida halophila, Candida krusei, Candida krusei, Candida krusei, Candida krusei, Candida krusei Candida sake, Candida tropicalis, Candida versatilis, Candida vulgaris, etc.), Castellani Genus a, Chlamydozyma, Chromotorula, Citeromyces, Cladosporium, Clavispora, Crebrothecium, Cryptococcus, Debaryomyces (Debaryomyces delbrueckii, Debaryomyces halotolerans, Debaryomyces hansenii etc.), Deberoozyma, Debaryozyma, Dipodascus, Eeniella, Endomyces, Endomycopsis, Eremascus, Eremothecium, Eutorulopsis, Fabospora, Fellomyces, Filobasidium, Galactomyces, Geotrichoides, Geotrichum, Guilliermondella, anomala, Hansenula kluyveri, Hansenula miso, Hansenula polymorpha, Hansenula wickerhamii etc.), Hypomyces, Issatchenkia, Kloeckera (Kloeckera brevis, Kloeckera fluoresceny, Kloeckera Etc.), Kockovaella genus, Kurtzmanomyces genus, Leucosporidium genus, Lipomyces genus, Metschnikowia , Microanthomyces genus, Monilia genus, Monospora genus, Monosporella genus, Mrakia genus, Myceloblastanon genus, Mycocandida genus, Mycoderma genus, Mycotorula genus, Mycotoruloides genus, Myxozyma genus, Nadsonia sp Genus, Oospora, Oosporidium, Pachysolen, Parasaccharomyces, Paratorulopsis, Parendomyces, Petasopsora, Pichia (Pichia amylophila, Pichia farinosa, Pichia guilliermondii, Pichia membranifaciens, Pichia moc Genus, Proteomyces genus, Pseudomonilia genus, Pseudosaccharomyces genus, Pseudozyma genus, Rhodomyces genus, Rhodosporidium genus, Rhodotorula genus, Saccharomyces genus (Saccharomyces aceti, Saccharomyces cerasi, Saccharomyces cerevisiae Genus, Saturnispora, Schizoblastosporion, Schizosaccharomyces, Schwanniomyces Selenotila genus, Selenozyma genus, Smithiozyma genus, Sporidiobolus genus, Sporobolomyces genus, Sporothrix genus, Stephanoascus genus, Sterigmatomyces genus, Sympodiomyces genus, Symingospora genus, Tetrapisispora genus, Torulaspora genus, Tordenpostomy genus, Torulopsiron genus, Torulopsisces genus Genus William, genus Williamopsis, genus Wingea, genus Xanthophyllomyces, genus Yamadazyma, genus Zendera, genus Zygofabospora, genus Zygopichia, genus Zygosaccharomyces, genus Zymodebaryomyces and the like. The microorganisms classified as bacteria include the genus Acetobacter (Acetobacter aceti, etc.), Achromobacter genus, Acidianus genus, Acidobacterium genus, Acidithiobacillus genus, Acrocarpospora genus, Actinoalloteichus genus, Actinocorallia genus, Actinokineospora genus, Actinomadospura genus, Actinomadspura Actinosynnema genus, Aerococcus genus, Aeromicrobium genus, Agrobacterium genus, Agromyces genus, Ahrensia genus, Alcaligenes genus, Alicyclobacillus genus, Alloiococcus spp. Aureobacterium genus, Azotobacter genus, Bacillus genus (Bacillus brevis, Bacillus subtilis etc.), Bacteroides genus, Beneckea genus, Bifidobacterium genus (Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis etc.), Brachybacterium genus, Brevicillus genus, Brevicillus, Brevundimonas, Burkholderia, Carnobacterium, Catellatospora, Cellulomonas sp Enterobacter sp Genus, Halobacterium genus, Halococcus genus, Herbidospora genus, Hydrogenophilus genus, Hyphomicrobium genus, Hyphomonas genus, Intrasporangium genus, Janibacter genus, Kinesia spp. Kocuria, Kurthia, Lactobacillus (Lactobacillus rimae, Lactobacillus divergens, Lactob acillus carnis, Lactobacillus piscicola, Lactobacillus acidophilus, Lactobacillus amylophilus, Lactobacillus animalis, Lactobacillus brevis, Lactobacillus casei, Lactobacillus curvatus, Lactobacillus bulgaricus, Lactobacillus delbrueckii, Lactobacillus fermentum, Lactobacillus fructivorans, Lactobacillus fructosus, Lactobacillus helveticus, Lactobacillus hilgardii, Lactobacillus homohiochii, Lactobacillus kefiri , Lactobacillus malefermentans, Lactobacillus murinus, Lactobacillus paracasei, Lactobacillus paracasei subsp. tolerans, Lactobacillus parakefiri, Lactobacillus pentosus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus sakei, Lactobacillus confusus, Lactobacillus viridescens, Lactobacillus johnsonii, Lactobacillus viscosus, Lactobacillus fermentatae, Lactobacillus acidophil-aerogenes, Lactobacillus leichmannii, Lactobacillus gasseri, Lactobacillus bifidus, Lactobacillus jugurt, Lactobacillus caucasicus Lactobacillus arabinosus, Lactobacillus kunkeei, Lactobacillus nagelii, Lactobacillus fornicalis, Lactobacillus pentoaceticus, Lactobacillus xylosus, Lactobacillus minutus, etc.), Leuconostoc genus (Leuconostoc lactis, Leuconostoc dextranicum, Leuconostoc mesenteroides, Leuconostoc oenos, Leuconostoc paramesenteroides, Leuconostoc cremoris, such as Leuconostoc citrovorum), Listonella Genus, Lucibacterium genus, Luteococcus genus, Magnetospirillum genus, Marinilabilia genus, Marinospirillum genus Mesorhizobium genus, Metallosphaera genus, Methylobacterium genus, Microbispora genus, Micrococcus genus, Microellobosporia genus, Micromonospora genus, Mycobacterium genus, Nocoides genus, Noiaides Genus, Nonomuria, Oceanospirillum, Ochrobactrum, Oerskovia, Oligella, Paenibacillus, Pediococcus (Pediococcus cerevisiae, Pediococcus pentosaceus, Pediococcus urinae-equi etc.), Pedobacterto, Pedobacterto , Planobispora, Planococcus, Planomonospora, Prevotella, Propionibacterium, Proteus, Protomonas, Pseudomonas, Pseudonocardia, Rahnella, Rarobacter, Rathayibacter, Rhizobium, Rhizomonas , Rhodospirillum genus, Rothia genus, Rubrobacter genus, Ruegeria genus, Saccharomonospora genus, Saccharothrix genus, Serratia genus, Sinorhizobium genus, Sphingobacterium genus, Sphingomonas genus, Sporolactobacillus genus, Stenotrophomonas genus, Streptoalloteococ genus Streptoalloteococ faecium, Streptococcus bovis, Streptococcus equinus, Streptococcus mutans, Streptococcus salivarius, Streptococcus thermophilus, Streptococcus agalactiae, Streptococcus mitis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus lactisdy uberis, Streptococcus cremoris, Streptococcus diacetilactis, etc.), Streptomyces genus, Streptosporangium genus, Streptoverticillium genus, Terrabacter genus, Thermoactinomyces genus, Thermobifida genus, Thermobispora genus, Thermohispera genus, Thermohispa genus, Thermopispa genus, Thermopispa genus, Thermopispa genus Genus, Xanthobacter genus, Xanthomonas genus, Zymomonas genus and the like. Microorganisms classified as non-yeast ascomycetes, basidiomycetes or incomplete fungi include Allomyces, Amoebidium, Amorphotheca, Arthroderma, Ascoidea, Ascobolus, Ascodesmis, Aspergillus, Aureobasidium, Botryosphaeria Botryotinia sp Genus, Dothidea genus, Endogone genus, Entomophthora genus, Emericella genus, Eupenicillium genus, Eurotium genus, Exobasidium genus, Gibberella genus, Glomus genus, Graphiola genus, Gymnoascus genus, Harpella genus, Helicomyces genus, Helvella genus, Hemicarpenteles genus, Hyphochytrium genus, Hyphochytrium Hypocrea, Laboulbenia, Labyrinthula, Leptosphaeria, Leptosphaerulina, Lophodermium, Melanotaenium, Microascus, Microstroma, Medeololaria, Melampsora , Melamsporella, Morchella, Monascus, Monilinia, Mycospharella, Nannizzia, Nectria, Neolecta, Neurospora, Nodulosphaeria, Olpidium, Peziza, Penicillium, Perenospora, Pestopolisis Genus, Pneumocystis genus, Preussia genus, Pleospora genus, Puccinia genus, Pythium genus, Ravenelia genus, Rickia genus, Rhinocladiella genus, Rhizidiomyces genus, Rhizoctonia genus, Sclerocleista genus, Saprolegnia genus, Sclerotinia genus, Sclerotum genus, Septobasidium genus, Septobasidium genus Examples include the genus Sporidiobolus, Stigmatomyces, Sydowiella, Talaromyces, Taphrina, Thraustochytrium, Tolyposporium, Trichoglossum, Trichoma, Ustilago, Verticillium, Xylaria and the like.

  In fermentation or metabolic conversion by microorganisms, in addition to various raw materials such as plant-based materials, animal-based materials, and other natural product-based materials, the growth and metabolism of microorganisms are regulated or activated, and special biosynthesis or degradation pathways are induced. In order to achieve this, various compounds can be added to the raw material. For example, as a carbon source, sugar, ethane such as glucose, fructose, galactose, sucrose, maltose, mannose, lactose, glycerin, starch, etc. , Hydrocarbons such as methane, propane, butane, formic acid, acetic acid, propionic acid, lauric acid, palmitic acid, fatty acids such as oleic acid, linoleic acid, linolenic acid, etc., nitrogen sources such as ammonium sulfate, ammonium hydrochloride, ammonium phosphate, etc. Ammonium salts, urea, uric acid, amino acids, etc. Vitamins and compounds containing potassium, calcium, magnesium, sodium, sulfur, phosphorus, chlorine, etc., as well as iron, copper, zinc, cobalt, nickel, boron, manganese, molybdenum, tin, selenium, silicon It is possible to further add compounds contained in the composition such as arsenic, vanadium, chromium and fluorine. In addition, the optimum temperature, oxygen supply amount, pH, pressure, etc. that affect the growth and metabolic activities of various microorganisms can be arbitrarily set according to the characteristics inherent to various microorganisms. Can be arbitrarily set within the range of 10 to 50 ° C., and the pH can be arbitrarily set within the range of 1 to 14.

  In fractionation or purification, generally known techniques can be used as appropriate. In addition to solvent extraction, for example, liquid chromatography (ion exchange chromatography, ion exclusion chromatography, affinity chromatography, gel filtration chromatography, size exclusion chromatography, etc.). Chromatography, hydrophilic adsorption chromatography, hydrophobic adsorption chromatography, ligand exchange chromatography, etc.), dialysis with semipermeable membrane, crystallization and recrystallization of components, filter paper, membrane filter, ultra filter, Examples thereof include filtration using activated carbon, filter aids, etc., centrifugal separation and its application, such as fractional precipitation method, density gradient separation method such as density gradient sedimentation equilibrium method, and the like.

Specific examples of other components used as additives in the preparation of the present invention include silica, magnesium silicate, talc, kaolin, bentonite, hectorite, natural or synthetic smectite, stevensite, mica, and mica titanium. , Inorganic pigments such as bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, bengara, black iron oxide, gunjou, chromium oxide, chromium hydroxide, carbon black, calamine Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, ortholine peroxide Sodium acid, Sodium iodate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide, etc. Reducing agents, redox agents such as thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate), 5-aminoorthocresol, 2-amino -4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, Toluene-2,5-diamine hydrochloride, nitroparaphenylene hydrochloride Amine, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5- Dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium picrate, N N′-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, Metaphenylenediamine, 5-aminoorthocresol sulfate , 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, sulfuric acid Nitroparaphenylenediamine, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine, catechol, diphenylamine, α- Natural movements such as naphthol, hydroquinone, phloroglucin, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulphonate, hematein and other dyes, musk, civet, castrium and ambergris Physical Flavor, Anise Essential Oil, Angelica Essential Oil, Ylang Ylang Essential Oil, Iris Essential Oil, Fennel Essential Oil, Orange Essential Oil, Kananga Essential Oil, Caraway Essential Oil, Cardamom Essential Oil, Guayak Wood Essential Oil, Cumin Essential Oil, Black Letter Essential Oil, Cinnamon Essential Oil, Geranium Essential Oil, Copaiba Balsam Essential Oil , Coriander essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil, otsuki aroma essential oil, tuberose essential oil, clove essential oil, orange flower essential oil, winter green essential oil, true Balsam essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, cocoon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot essential oil, peru balsam essential oil, boadrose essential oil, melamine essential oil, mandarin essential oil, eucalyptus essential oil, Im essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, vegetable flavors such as Japanese mint essential oil, other synthetic flavors, 5-amino-o-cresol, o-aminophenol, m-aminophenol, p-aminophenol, 2,6-diaminopyridine, 5- (2-hydroxylethylamino) -2-methylphenol, N, N-bis (β-hydroxyl) -p-phenylenediamine sulfate, N, N-bis (2-hydroxyethyl) -p-phenylenediamine, p-nitro-o-phenylenediamine, p-phenylenediamine, m-phenylenediamine, N-phenyl-p-phenylenediamine, 2-hydroxy-5 -Nitro-2 ', 4'-diaminoazobenzenesodium sulfate, toluene-2,5-diamine, 2- (2'-hydroxyethylamino) -5-aminotoluene, N, N-bis (β-hydroxyl) -p -Phenylenediamine, N, N-bi (2-hydroxyethyl) -p-phenylenediamine sulfate, 5-amino-o-cresol sulfate, p-aminophenol sulfate, o-chloro-p-phenylenediamine sulfate, 2- (2'-hydroxy Ethylamino) -5-aminotoluene sulfate, 4,4'-diaminodiphenylamine sulfate, p-methylaminophenol sulfate, p-phenylenediamine sulfate, m-phenylenediamine sulfate, toluene-2,5-diamine Sulfate, 2,4-diaminophenoxyethanol hydrochloride, toluene-2,5-diamine hydrochloride, m-phenylenediamine hydrochloride, 2,4-diaminophenol hydrochloride, 3,3'-iminodiphenol, p-phenylene Diamine hydrochloride, N-phenyl-p-phenylenediamine hydrochloride, N-phenyl-p-phenylenediamine acetate, 1,5-dihydroxynaphthalene, toluene-3,4-diamine, p-methylaminophenol, N, N '-Bis (4- Minophenyl) -2,5-diamino-1,4-quinonediimine, o-aminophenol sulfate, 2,4-diaminophenol sulfate, m-aminophenol sulfate, 2-amino-4-nitrophenol, 2-amino -5-nitrophenol, 1-amino-4-methylaminoanthraquinone, nitro-p-phenylenediamine hydrochloride, 1,4-diaminoanthraquinone, nitro-p-phenylenediamine, picramic acid, sodium picrate, 2-amino- 5-nitrophenol sulfate, resorcinol, nitro-p-phenylenediamine sulfate, p-nitro-o-phenylenediamine sulfate, p-nitro-m-phenylenediamine sulfate, red No. 2, red No. 3, red 102 No., Red 104 (1), Red 105 (1), Red 106, Red 201, Red 227, Red 230 (1), Red 230 (2), Red 231, Red 232, Red 401, Red 502, Red 503, Red 504 , Red 506, yellow 4, yellow 5, yellow 202 (1), yellow 202 (2), yellow 203, yellow 402, yellow 403 (1), yellow 406, yellow 407, orange 205, orange 207, orange 402, green 3, green 204, green 205, green 205, green 401, green 402, brown 201, purple 401, blue 1, blue 2 , Blue 202, Blue 203, Blue 205, Black 401, Red cabbage dye, Red potato dye, Catechol tannin, Red rice dye, Akane dye, Anato dye, Ikumi dye, Turmeric dye, Enju dye, Krill dye, Amber pigment, Caramel, Gold, Silver, Gardenia pigment, Corn pigment, Onion pigment, Tamarind pigment, Spirulina pigment, Cherry pigment, Nori pigment, Hibiscus pigment, Grape juice pigment, Grape skin pigment, Marigold pigment, Purple potato pigment, Purple Dye and colorants such as yam pigment, lac pigment, rutin, avoca Oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange raffer oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber nut oil, safflower oil, shea butter, liquid shea Fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, coconut oil, beef tallow, lard Or oils and fats such as hydrogenated products (hardened oil, etc.), beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax, squalene, squalane, pristane Waxes, liquid paraffin, petrolatum, paraffin, ozokelide Mineral oils such as ceresin and microcristan wax, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, Natural fatty acids such as tall oil, lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid, isopentanoic acid and other fatty acids such as ethanol, isopyropanol , Lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, and other natural alcohols, 2-hexyldecanol, isostearyl alcohol, 2-octyl Alcohols such as synthetic alcohols such as dodecanol, isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, adipine Diisobutyl acid, 2-hexyldecyl adipate, diheptylundecyl adipate, N-alkyl glycol monoisostearate, isocetyl isostearate, trimethylolpropane triisostearate, ethylene glycol diethyl hexanoate, neopentyl glycol diethyl hexanoate, 2- Cetyl ethylhexanoate, trimethylolpropane triethylhexanoate, pentaerythritol tetraethylhexanoate, octanoic acid Cetyl, octyldodecyl gum, cetyl lactate, myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, aluminum stearate, stearic acid Magnesium, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate, etc., anionic surfactants (alkyl carboxylates, alkyl sulfonates, alkyl sulfates, Alkyl phosphate ester salts), alkyl sulfate ester salts (sodium lauryl sulfate, potassium lauryl sulfate, triethanolamine lauryl sulfate, ammonium lauryl sulfate, Sodium sulfate, sodium stearyl sulfate, etc.), secondary alcohol sulfate, alkyl ether sulfate (for example, polyoxyethylene lauryl sulfate triethanolamine, polyoxyethylene lauryl sodium sulfate, etc.), alkyl and alkyl allyl ether sulfates Salt (N-acyl methyl alanine salt, N-acyl glutamate, N-acyl methyl taurate, N-acyl isethionate, N-acyl glycine salt, alkyl phosphate, alkyl ether carboxylate, alkyl sulfonate, Alkylsulfosuccinate, sodium polyoxyethylene lauryl ether sulfate, polyoxyethylene lauryl ether sulfate triethanolamine, polyoxyethylene lauryl ether ammonium sulfate, polyoxyethylene alkyl ether Sodium tersulfate, polyoxyethylene alkyl ether triethanolamine sulfate, polyoxyethylene alkyl ether sulfate diethanolamine, polyoxyethylene alkyl ether ammonium sulfate, etc.), higher fatty acid alkylolamide sulfate, higher fatty acid ester sulfate (cured coconut oil) Fatty acid sodium glycerine sulfate, etc.), polyoxyethylene alkyl ether carboxylic acid, polyoxyethylene alkyl allyl ether carboxylate, sulfated oil such as sulfated castor oil, mono or dialkyl or alkenyl phosphate ester salt, polyoxyethylene mono or Dialkyl or alkenyl phosphate ester salts (sodium monolauryl phosphate, sodium isostearyl phosphate, arginine 2-hexyldecyl phosphate, 2-heptyl u Potassium decyl acid, polyoxyethylene (4-10) la
Sodium uryl ether phosphate, sodium monocetyl phosphate, arginine monomyristyl phosphate, sodium monooleyl phosphate, potassium polyoxyethylene (2-10) potassium lauryl ether, sodium dioctyl phosphate, etc.), polyoxyethylene alkyl ether phosphorus Acid ester salts (polyoxyethylene lauryl ether phosphate, polyoxyethylene oleyl ether phosphate, polyoxyethylene cetyl ether phosphate, polyoxyethylene stearyl ether phosphate, polyoxyethylene alkyl ether phosphate, polyoxyethylene alkyl phenyl ether Phosphoric acid, etc.), sulfonates of higher fatty acid amides or sulfonates of higher fatty acid esters (α-olefin sulfonate, N-myristoyl-N-methyltaurine sodium, coconut oil Fatty acid methyl taurine sodium, lauroyl methyl taurine sodium, etc.), alkylbenzene sulfonate (dodecylbenzenesulfonic acid, dodecylbenzenesulfonic acid monoethanolamine, dodecylbenzenesulfonic acid diethanolamine, dodecylbenzenesulfonic acid triethanolamine, dodecylbenzenesulfonic acid sodium salt) Etc.), sulfosuccinate (sodium diethylhexyl sulfosuccinate, sodium sulfosuccinate, disodium lauryl sulfosuccinate, disodium polyoxyethylene sulfosuccinate, disodium polyoxyethylene sulfosuccinate lauryl, polyoxyethylene lauroyl ethanolamide ester sulfosuccinate Sodium, disodium undecylenoylamidoethylsulfosuccinate, Nolauroyl monoethanolamide polyoxyethylene sodium sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc.), N-acyl sarcosine salts (eg, lauroyl sarcosine sodium, palmitoyl sarcosine sodium), condensates of higher fatty acids and amino acids (N-acyl glutamate) , Sodium N-stearoyl glutamate, potassium N-palmitoyl glutamate, sodium N-lauroyl-L-glutamate, disodium N-stearoyl-L-glutamate, sodium N-myristoyl-L-glutamate, sodium myristoyl methyl taurate, sodium palmitoyl methyl taurate , Stearoyl methyl taurine sodium, N-palmitoyl-β-alanine arginine, N-palmitoyl aspartate ditriethanola Anionic surfactants such as fatty acid soaps such as oleate, suarenate, laurate, palmitate, etc. (examples of anionic surfactant salts include alkali salts such as sodium salts and potassium salts). Metal salts, monoethanolamine salts, diethanolamine salts, triethanolamine salts, L-lysine salts, organic ammonium salts such as L-arginine salts, ammonium salts, etc.), quaternary ammonium salts (alkyltrimethylammonium chloride, Cetyl ammonium chloride, cetyl ammonium bromide, lauryl ammonium chloride, lauryl ammonium bromide, stearyl ammonium chloride, stearyl ammonium bromide, cetyl dimethyl ammonium chloride, cetyl dimethyl ammonium bromide, lauryl dimethyl ammonium chloride, stearyl dimethyl chloride Ruammonium, lauryltrimethylammonium chloride, lauryltrimethylammonium bromide, stearyldimethylcetylditallowdimethylammonium chloride, dicetylammonium chloride, dicetylammonium bromide, dilaurylammonium chloride, dilaurylammonium bromide, distearylammonium chloride, Distearylammonium bromide, dicetylmethylammonium chloride, dicetylmethylammonium bromide, dilaurylmethylammonium chloride, dilaurylmethylammonium bromide, distearylmethylammonium chloride, distearylmethylammonium bromide, cetyltrimethylammonium chloride, Cetyltrimethylammonium bromide, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, bromide Lauryltrimethylammonium chloride, dialkyldimethylammonium chloride, dicetyldimethylammonium chloride, distearyldimethylammonium chloride, dicocoyldimethylammonium chloride, myristyldimethylbenzylammonium chloride, stearyldimethylbenzylammonium chloride, ethyl lanolin sulfate fatty acid aminopropylethyldimethylammonium chloride Cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, behenyltrimethylammonium chloride, behenyldimethylhydroxyethylammonium chloride, stearyldimethylbenzylammonium chloride, distearyldimethylammonium chloride, distearoylethylhydroxyethylmonium metasulfate, dicocoylethylhydroxyethylmolybdate Ummetasulfate, dipalmitoylethylhydroxyethylmonium metasulfate, and cetyltriethylammonium methylsulfate, alkyltrimethylammonium chloride, alkyldimethylbenzylammonium chloride, dialkyldimethylammonium chloride, alkyltrimethylammonium bromide, alkylpentaethoxyammonium chloride, ditallow Dimethyl ammonium chloride, ditallow dimethyl ammonium methyl sulfate, ditallow dipropyl ammonium phosphate, ditallow dimethyl ammonium nitrate, di (coconut alkyl) dimethyl ammonium chloride, di (coconut alkyl) dimethyl ammonium bromide, coconut ammonium chloride, stearamide propyl PG-dimonium chloride, stearua Dopropyl ethyl dimonium esosulphate, stearamide propyl dimethyl (myristyl acetate) ammonium chloride, stearamide propyl dimethyl cetearyl ammonium tosylate, stearamide propyl dimethyl ammonium chloride, stearamide propyl dimethyl ammonium lactate, ethyl lanolin sulfate Fatty acid aminopropylethyldimethylammonium, cationized cellulose, acyldiethylaminoethylamide, acyldimethylaminopropylamide, polyoxyethylene fatty acid amide, myristyldimethylamine oxide, N-lauryldimethylaminoacetic acid betaine, N-myristyldimethylaminoacetic acid betaine, N -Stearyldimethylaminoacetic acid betaine), bis fatty acid ester salts (hydroxypropyl-bis-laur) Amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-myristate amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-palmitic acid amidopropyl-N, N-dimethylammonium chloride, hydroxy Propyl-bis-stearic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-behenic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-oleic acid amidopropyl-N, N-dimethyl Ammonium chloride, hydroxypropyl-bis-isostearic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis- Fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-tallow fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-lauric acid amidoethyl-N, N-diethylammonium chloride, hydroxy Propyl-bis-myristate amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palmitamidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-amidoethyl stearate-N, N-diethylammonium chloride, Hydroxypropyl-bis-behenamidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-oleic acidamidoethylammonium chloride, hydroxypropyl-bis-isostearic acid amide Chill-N, N-diethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-tallow Fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-lauric acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-myristic amidopropyl-N, N-diethylammonium chloride, hydroxypropyl- Bis-palmitic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-stearic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-behenic acid amidopropyl- N, N-diethylammonium chloride, hydroxypropyl-bis-oleic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-isostearic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-coconut Fatty acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-tallow fatty acid amidopropyl-N, N-diethylammonium chloride), Stearamidepropyl PG-dimonium chloride phosphate, behenamidopropyl PG dimonium chloride, stearamidepropylethyldimonium ethosulphate, stearamidepropyldimethyl (myristyl acetate) chloride Cationic surfactants such as nium, stearamidepropyldimethylcetearylammonium tosylate, stearamidepropyldimethylammonium chloride, stearamidepropyldimethylammonium lactate, glycerin fatty acid esters (glyceryl monoundecylenate, glyceryl diundecylenate) Glyceryl monomyristate, glyceryl dimyristate, glyceryl monopalmitate, glyceryl dipalmitate, glyceryl monostearate, glyceryl distearate, glyceryl monooleate, mono cottonseed oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, mono Glyceryl stearate, α, α'-oleic acid pyroglutamate glycerin, glyceryl monostearate malate, etc.), polyglycerin Fatty acid esters (diglyceryl monomyristate, diglyceryl dimyristate, diglyceryl trimyristate, diglyceryl monopalmitate, diglyceryl dipalmitate, diglyceryl tripalmitate, diglyceryl monostearate, diglyceryl distearate) Diglyceryl tristearate, diglyceryl monooleate, diglyceryl dioleate, diglyceryl trioleate, tetraglyceryl monopalmitate, tetraglyceryl dipalmitate, tetraglyceryl tripalmitate, tetraglyceryl tetrapalmitate, pentapalmitin Tetraglyceryl acid, tetraglyceryl monostearate, tetraglyceryl distearate, tetraglyceryl tristearate, tetraglyceryl tetrastearate , Tetraglyceryl pentastearate, tetraglyceryl monooleate, tetraglyceryl dioleate, tetraglyceryl trioleate, tetraglyceryl tetraoleate, tetraglyceryl pentaoleate, hexaglyceryl monopalmitate, hexaglyceryl dipalmitate, tri Hexaglyceryl palmitate, hexaglyceryl tetrapalmitate, hexaglyceryl pentapalmitate, hexaglyceryl monostearate, hexaglyceryl distearate, hexaglyceryl tristearate, hexaglyceryl tetrastearate, hexaglyceryl pentastearate, hexaoleate monooleate Glyceryl, hexaglyceryl dioleate, hexaglyceryl trioleate, hexaglyceryl tetraoleate Lil, penta oleic hexaglyceryl monopalmitate decaglyceryl dipalmitate decaglyceryl, decaglyceryl tripalmitate, Tet
Decaglyceryl lapalmitate, decaglyceryl pentapalmitate, decaglyceryl hexapalmitate, decaglyceryl heptapalmitate, decaglyceryl octapalmitate, decaglyceryl nonapalmitate, decaglyceryl monostearate, decaglyceryl monostearate, distearic acid Decaglyceryl, decaglyceryl tristearate, decaglyceryl tetrastearate, decaglyceryl pentastearate, decaglyceryl hexastearate, decaglyceryl heptearate, decaglyceryl octastearate, decaglyceryl nonostearate, decaglyceryl decastearate , Decaglyceryl monooleate, Decaglyceryl dioleate, Decaglyceryl trioleate, Decatetraoleate Lyceryl, decaglyceryl pentaoleate, decaglyceryl hexaoleate, decaglyceryl heptaoleate, decaglyceryl octaoleate, decaglyceryl nonaoleate, decaglyceryl monohydroxystearate, decaglyceryl dihydroxystearate, decaglyceryl dihydroxystearate, tri Decaglyceryl hydroxystearate, decaglyceryl tetrahydroxystearate, decaglyceryl pentahydroxystearate, decaglyceryl hexahydroxystearate, decaglyceryl heptahydroxystearate, decaglyceryl octahydroxystearate, decaglyceryl nonahydroxystearate, decahydroxyl Decaglyceryl stearate, hexaglyceryl polyricinoleate, poly Decaglyceryl synolate, polyoxyethylene glyceryl monostearate, polyoxyethylene glyceryl distearate, polyoxyethylene glyceryl monooleate, polyoxyethylene glyceryl monomyristic acid), polyoxyethylene glycerin fatty acid ester (polyoxyethylene glyceryl monoester) Stearate, polyoxyethylene glycerol monoisostearate, polyoxyethylene glycerol triisostearate, etc.), sorbitan fatty acid ester (sorbitan monolaurate, sorbitan monooleate, sorbitan sesquioleate, sorbitan trioleate, sorbitan monopalmitate) Sorbitan monostearate, sorbitan distearate, sorbitan dioleate, sorbitan monopalmitate, Sorbitan ristearate, sorbitan trioleate, diglycerin sorbitan penta-2-ethylhexylate, diglycerin sorbitan tetra-2-ethylhexylate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polypalmitate monopalmitate Oxyethylene sorbitan, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan trioleate, polyoxyethylene sorbitan pentaoleate, propylene glycol fatty acid ester (propylene glycol monooctanoate, propylene glycol monodecanoate, propylene glycol monostearate) ), Sucrose fatty acid ester (monolauric acid sucrose ester, dilauric acid sucrose ester, monopalmitic acid sucrose Ester, dipalmitic acid sucrose ester, monostearic acid sucrose ester, distearic acid sucrose ester, etc.), dextrin fatty acid ester (such as dextrin palmitate), coconut oil fatty acid alkanolamide, polyoxyethylene castor oil, polyoxyethylene cured Castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, polyoxyethylene hydrogenated castor oil maleic acid, polyoxy Ethylene alkyl ether (alkyl polyglucoside, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene behenyl ether, polyoxyethylene Rail ether, polyoxyethylene lauryl ether, polyoxyethylene-2-octyldodecyl ether, polyoxyethylene cholestanol ether, etc.), polyoxyethylene alkylphenyl ether (polyoxyethylene nonylphenyl ether, polyoxyethylene octylphenyl ether, etc.) , Polyoxyethylene fatty acid esters (polyethylene glycol monooleate, polyethylene glycol monostearate, polyethylene glycol monolaurate, etc.), lanolin derivatives (polyoxyethylene lanolin, polyoxyethylene lanolin alcohol, polyoxyethylene sorbitol lanolin, etc.), POE POP-alkyl ether (POE / POP-cetyl ether, POE / POP-2-decyltetradecyl ether, POE / POP-monobutyl ether, POE / POP-water Nonionic surfactants such as lanolin, POE / POP-glycerin ether, tetronic, etc.), alkanolamides (coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.), betaine-type amphoteric surfactants (2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, sodium undecylcarboxymethoxyethylcarboxymethylimidazolinium betaine, sodium undecylhydroxyethylimidazolinium betaine, undecyl- N-hydroxyethyl-N-carboxymethylimidazolinium betaine, alkyldiaminoethylglycine hydrochloride, stearyl dihydroxyethyl betaine, stearyldimethylaminoacetic acid betaine, stear Lildimethylbetaine solution, coconut oil alkyl-N-carboxyethyl-N-hydroxyethylimidazolinium betaine sodium, coconut oil alkylbetaine, coconut oil alkyldimethylaminoacetic acid betaine, coconut oil fatty acid amidopropyl betaine, coconut oil fatty acid-N -Carboxymethoxyethyl-N-carboxyethylimidazolinium betaine sodium, N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, N-cocoyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium , Lauryldimethylaminoacetic acid hydroxysulfobetaine, palm oil alkyldimethylaminoacetic acid hydroxysulfobetaine, laurylaminopropionic acid triethanolamine, β-laurylaminopropionic acid sodium salt, Amidopropyl dimethylaminoacetic acid betaine laurate, Amidopropyl dimethylaminoacetate hydroxysulfobetaine, fatty acid amidopropyldimethylaminoacetic acid hydroxysulfobetaine, Palm oil fatty acid amidopropyldimethylaminoacetic acid hydroxysulfobetaine, Palm oil fatty acid amidopropyldimethyl Aminoacetic acid betaine, palm oil fatty acid amidopropyldimethylaminoacetic acid betaine, lauryl-N-carboxymethoxyethyl-N-carboxymethylimidazolinium disodium dodecanoyl sarcosine, sodium lauryldiaminoethylglycine, lauric acid amidopropyl betaine solution, lauryl sulfo Betaine, laurylhydroxysulfobetaine, 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazo Nitrobetaine, Cocodimethylcarboxymethylbetaine, Lauryldimethylcarboxymethylbetaine, Lauryldimethylalphacarboxyethylbetaine, Cetyldimethylcarboxymethylbetaine, Cetyldimethylbetaine, Laurylbis- (2-hydroxyethyl) carboxymethylbetaine, Stearylbis- (2- (Hydroxypropyl) carboxymethylbetaine, oleyldimethylgamma-carboxypropylbetaine, laurylbis- (2-hydroxypropyl) alpha-carboxyethylbetaine, cocodimethylsulfopropylbetaine, stearyldimethylsulfopropylbetaine, lauryldimethylsulfoethylbetaine, laurylbis- ( 2-Hydroxyethyl) sulfopropylbetaine, Levon 2000 (Sanyo Kasei), palm oil fatty acid amide pro Pyrdimethylbetaine, palm oil fatty acid amidopropylsulfobetaine, imidazolinium type amphoteric surfactant (bis (stearyl-N-hydroxyethylimidazoline) chloroacetic acid complex, N-alkyl-N-carboxymethyl-N-hydroxyethylimidazo Linium betaine, N-alkyl-N-carboxymethyl-N-hydroxyethylethylenediamine lauryl sulfate and its salts, coconut oil alkyl-N-carboxyethoxyethyl-N-carboxyethylimidazolinium disodium hydroxide, coconut oil alkyl -N-carboxymethoxyethyl-N-carboxyethylimidazolinium disodium hydroxide, palm oil alkyl-N-carboxymethoxyethyl-N-carboxyethylimidazolinium disodium lauryl sulfate, 2-undecyl-N, N, N -(Hydroxyethylcarboxyme 2) -2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, ovazoline 662 (Toho Chemical Co., Ltd.), Swanol AM-101 (Nikko Chemicals Co., Ltd.), aminopropion Acidic amphoteric surfactant (alkylaminopropionic acid such as sodium dodecylaminopropionate, alkylaminodipropionic acid, etc.), sodium dodecylaminopropanesulfonate, N-higher alkylaspartic acid or its salt, coamidopropyl chlorinated polyethylene glycol Dimonium phosphate, cocamidopropyl hydroxysultain, sodium lauroyl sarcosinate, alkylamine oxide (decylamine oxide, cocoamine oxide, myristoylamine oxide, palmitoylamine oxide, alkyldimethylamine oxide) Amphoteric surfactants such as xoxide, alkylamidopropylamine oxide), natural surfactants (lecithin, sodium caseinate, sphingolipid, saponin, mannosyl polyhydric alcohol fatty acid ester, glucosyl polyhydric alcohol fatty acid ester, galactosyl polyhydric alcohol) Monosaccharide polyhydric alcohol fatty acid esters such as fatty acid esters or disaccharide polyhydric alcohol fatty acid esters, oligosaccharide polyhydric alcohol fatty acid esters, etc.) and amino acid surfactants (capric acid chloride, lauric acid chloride, myristic acid chloride, palmitic acid) Fatty acid chlorides such as chloride, stearic acid chloride, oleic acid chloride, behenic acid chloride, coconut oil fatty acid chloride and glycine, sarcosine, β-alanine, N-methyl-β-alanine, taurine, N- Reactants with amino acids in a broad sense such as tiltaurine), silicone surfactants (silicon KF-6011 (manufactured by Shin-Etsu Chemical Co., Ltd.), KF-6012 (manufactured by Shin-Etsu Chemical Co., Ltd.), KF-6013 (manufactured by Shin-Etsu Chemical Co., Ltd.) ), KF-6015 (Shin-Etsu Chemical Co., Ltd.), KF-6016 (Shin-Etsu Chemical Co., Ltd.), KF-6017 (Shin-Etsu Chemical Co., Ltd.), X-22-4991 (Shin-Etsu Chemical Co., Ltd.), NUC Silicon Polyoxyalkylene-modified organopolysiloxanes such as L7002 (Nippon Unicar), SH-3772C (Toray Dow Corning Silicone), SH-3775C (Toray Dow Corning Silicone), ABIL EM-90 (Gold Schmidt) ), ABIL B9806 (manufactured by Goldschmidt), silicone KF-6026 (manufactured by Shin-Etsu Chemical Co., Ltd.), etc., long-chain alkyl-containing polyoxyalkylene-modified organopolysiloxane), polyether-modified silicone (polyoxyethylene, methylpoly) Siloxane copolymer, poly (oxyethylene Oxypropylene) methylpolysiloxane copolymer, etc.), oxazoline-modified organopolysiloxane, alkyl-modified organopolysiloxane, styryl ketone silicone derivatives, dimethylpolysiloxane, methylphenylpolysiloxane, epoxy-modified silicone, fluorine-modified silicone, alcohol-modified Silicone, alkyl-modified silicone, alkoxy-modified silicone, amino-modified silicone, ammonium-modified polymer silicone, organopolysiloxane, methylphenylpolysiloxane, polysiloxane, poly (N-acylalkyleneimine) -modified silicone, dimethylpolysiloxane, nitrogen-containing acrylic -Silicone-based graft copolymer, decamethylcyclopentasiloxane, fluorine-substituted alkyl-modified silicone, organopolysiloxane Kisa alkenyl silyl alkyl-modified silicone, tricyclic Jiteru Bae Nkarubon acid-modified silicone, trifluoroalkyl-modified silica
Corn, divinylpolydimethylsiloxane, dihydrogenpolydimethylsiloxane, dihydrogenpolydimethylsiloxane divinylpolydimethylsiloxane polymer, trimethylsiloxysilicate, polyoxypropylene / methylpolysiloxane copolymer, ethylpolysiloxane, ethylmethylpolysiloxane, Ethylphenyl polysiloxane, octamethylcyclotetrasiloxane, diorganopolysiloxane, octamethylcyclotetrasiloxane, tetramethyltetraphenyltetracyclosiloxane, polyether modified polysiloxane, amino modified polysiloxane, epoxy modified polysiloxane, fluorine modified poly Siloxane, alcohol-modified polysiloxane, alkyl-modified polysiloxane, dodecamethylcyclohexasiloxane, lauric Methicone copolyol, aminoethylaminopropylsiloxane / dimethylsiloxane copolymer, silicone compounds such as eugenol-modified silicone, selenium disulfide, alkylisoquinolinium bromide, zinc pyrithione, biphenamine, thianthol, quinine hydrochloride, strong ammonia water, etc. And the like.

  Others, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, refreshing agents, stabilizers, emulsifiers, animal / plant proteins and their degradation products, animal / plant polysaccharides and their Degradation products, animal / plant glycoproteins and their degradation products, anti-inflammatory agents, antiallergic agents, wound treatment agents, foaming agents, thickeners, enzymes, purified water (electronic water, small clustering, etc.), deodorant / A deodorizing agent or the like can be used in combination.

  Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

[Production Example 1]
100 g of cowpea fruit was pulverized, added to 1.0 kg of 40% aqueous ethanol solution, immersed and extracted at room temperature to warm, and then suction filtered using filter paper to obtain 1.0 kg of cowpea extract.

[Production Example 2]
100 g of Ibuquitorano rhizome is pulverized, added to 1.0 kg of 50% 1,3-butylene glycol aqueous solution, soaked and extracted at room temperature to warm, and then filtered with suction using filter paper to obtain Ibuquitorano extract 1.0 kg was obtained.

[Production Example 3]
100 g of gosho strawberry fruit was pulverized, added to 1.0 kg of water, extracted by immersion under normal temperature to warming, and then suction filtered using filter paper to obtain 1.0 kg of gosho strawberry extract.

[Production Example 4]
100 g of white willow bark was pulverized, added to 1.0 kg of acetone, immersed and extracted at room temperature to warm, and then suction filtered using filter paper to obtain 1.0 kg of white willow extract.

[Production Example 5]
100 g of yellow cucumber seeds were pulverized, added to 1.0 kg of 50% ethanol aqueous solution, soaked and extracted at room temperature to warm, and then suction filtered using filter paper to obtain 1.0 kg of yellow cucumber extract.

[Production Example 6]
100g of Alpinia katsudai seeds are pulverized, added to 1.0kg of 50% ethanol aqueous solution, soaked and extracted at room temperature to warm, and then suction filtered using filter paper to obtain 1.0kg of alpinia katsudaidai extract. It was.

[Example 1]
As an overview, B16 melanoma cells were treated with the plant extract obtained in Production Example 1-6, and after culture, S6K1 phosphate, which is a target protein of mTOR, was converted to Western using an anti-P-S6K1 antibody. Detected by blotting method. The ratio of the band with respect to the control was calculated and used as mTOR activity. This test was conducted three times and the average was obtained. Detailed test methods are described below.
1. Preparation of cell lysate Each plant extract obtained in Production Examples 1 to 6 was dried and dissolved in DMSO to a solid content concentration of 5 mg / mL, and used as a test sample. B16 melanoma cells were seeded in a 6-well plate and cultured to 10% FBS-containing DMEM medium (manufactured by Sigma) until subconfluent. After culturing the cells in a DMEM medium containing 1% FBS for 12 hours, 25 μL of each plant extract was added to 1.0 mL of the medium and cultured for 8 hours. As a control, 25 μL of DMSO alone was added. The cells were dissolved in RIPA buffer (10 mM Tris-HCl, pH 7.5, 1.0% Nonidet P-40, 0.1% Sodium deoxycholate, 0.1% SDS, 150 mM NaCl, 1 mM EDTA). The mixture was then centrifuged for 15 minutes at 4 ° C. and 15000 g, and the lysate was stored at −80 ° C. until use.
2. Western blot analysis Cell lysates were separated on SDS-polyacrylamide gels. After electrophoresis, the protein was blotted onto a PVDF membrane. The membrane was blocked with blocking buffer (Tris buffered saline containing 0.1% Tween and 5% low fat milk) for 1 hour. The membrane was then washed with washing buffer (Tris buffered saline containing 0.1% Tween). Thereafter, the membrane was incubated with an anti-P-S6K1 antibody (manufactured by Cell Signaling Techonology) in a blocking buffer for 1 hour at room temperature. The blot was then washed with washing buffer and incubated with secondary antibody (Amersham) for 1 hour at room temperature. Then, after binding of the secondary antibody, the plate was sequentially washed with a washing buffer and Tris buffered saline, and then S6K1 phosphate was detected with an ECL-PLUS Western blotting detection reagent (Amersham). Densitometric analysis of the intensity of the band was performed, and the ratio with the control was calculated to obtain mTOR activity.

[Results of Examples]
As a result of testing the mTOR activation effect of each extract, it was 1.65 times for the cowpea extract, 1.28 times for the Ibukitorano extract, 1.56 times for the Gosho strawberry extract and 1.56 times for the white willow extract. Was 1.58 times, 1.75 times for Kurikarasuuri extract, and 2.15 times mTOR activity for Alpinia katsudai extract. Accordingly, it has been found that each extract used in the present invention is remarkably excellent in the action of activating mTOR.

(Manufacturing examples of various preparations)
Various dosage forms according to the present invention were prepared. Although the formulation example is shown below, this invention is not necessarily limited to these.

(Formulation Example 1) Whitening emulsion weight%
Polyether-modified organopolysiloxane 5.0
Diglyceryl monostearate 1.5
Decamethylcyclotetrasiloxane 20.0
Dimethylpolysiloxane 10.0
Liquid paraffin 10.0
Fragrance 0.1
Catalpa extract of Production Example 1 0.05
Ibukitrano extract of Production Example 2 0.05
1,3-butylene glycol 15.0
Sodium chloride 0.2
Purified water remaining

(Prescription Example 2) Whitening serum (% by weight)
Sorbitan sesquiisostearate 3.0
Decamethylcyclopentasiloxane 10.0
Isononyl isomyristate 8.0
Perfluoropolyether 0.5
Fragrance 0.1
Gosho strawberry extract of Production Example 3 0.1
White Willow extract of Production Example 4 0.1
Glycerin 3.0
Propylene glycol 10.0
Ascorbic acid-2 glucoside 3.0
Sodium citrate 0.5
Purified water remaining

(Formulation example 3) Cream weight%
Vaseline 8.0
N- (3-hexadecyloxy-2-hydroxypropyl)
-N-2-Hydroxyethylhexadecanamide 2.0
Squalene 20.0
Cetanol 5.0
Glycerol monostearate2.0
Polyoxyethylene (20)
Sorbitan monolaurate 2.0
Arginine 0.1
Ceramide 3 0.5
Sodium monohydrogen phosphate 0.85
Yellow cucumber extract of Production Example 5 0.2
Alpinia bonito extract of Production Example 6 0.2
Glycerin 5.0
1,3-butylene glycol 5.0
Dimethylpolysiloxane 3.0
Fragrance 0.1
Purified water remaining

(Formulation example 4) whitening lotion weight%
Sorbitol 2.0
1,3-butylene glycol 4.0
Cattle extract of production example 1 0.08
Polyoxyethylene (25) oleyl ether 2.0
Carboxyvinyl polymer 0.2
Ethanol 15.0
Purified water remaining

(Formulation Example 5) Foundation weight%
Decamethylcyclopentasiloxane 45.0
Dimethylpolysiloxane 5.0
Dimethyl distearyl ammonium hectorite 4.0
Hydrophobized titanium oxide 10.0
Hydrophobic talc 6.0
Hydrophobized mica 6.0
Hydrophobic treatment Bengala 1.6
Hydrophobized yellow iron oxide 0.7
Hydrophobized black iron oxide 0.2
Ibukitorano extract of Production Example 2 0.3
Dipropylene glycol 5.0
2-Amino-2-methyl-1,3-propanediol 0.5
Fragrance 0.1
Purified water remaining

(Formulation Example 6) Lipstick Weight%
Cadilla wax 5.0
Ceresin wax 15.0
Beeslow 3.0
Decamethylcyclopentasiloxane 15.0
Propylene glycol dicaprate 10.0
Polyglyceryl diisostearate8.0
Sorbitan sesquioleate 1.0
Polyether-modified organopolysiloxane 2.0
Gosho strawberry extract of Production Example 3 0.2
1,3-butylene glycol 1.0
Red 201 No.1.5
Yellow No. 401 1.0
Hydrophobized titanium oxide 1.0
Hydrophobic treated mica titanium 5.0
Fragrance 1.0
Cetyl isooctanoate

(Formulation Example 7) Face wash weight%
Lauryl phosphate triethanolamine 18.0
Lauric acid triethanolamine 2.5
Myristic acid triethanolamine 2.5
White Willow Extract of Production Example 4 0.4
Glycerin 16.0
Triisostearic acid polyoxyethylene (160) sorbitan 2.0
Cationized cellulose 0.5
Acrylic acid methacrylate alkyl copolymer 0.5
Lauryl hydroxysulfobetaine 5.0
Fragrance 0.1
Purified water remaining

(Formulation example 8) Body shampoo% by weight
Sodium citrate 2.0
N-acetylglutamic acid 1.0
Potassium laurate 15.0
Potassium myristate 5.0
Chestnut cucumber extract of Production Example 5 0.4
Propylene glycol 5.0
Sorbitol 3.0
Methylpolysiloxane 1.5
Amino-modified dimethylpolysiloxane 2.5
Polyethylene powder 0.5
Hydroxypropyl chitosan 0.5
Fragrance 0.1
Purified water remaining

(Formulation Example 9) Bath agent Weight%
Sodium bicarbonate 60.0
Borax 5.0
Sodium hyaluronate 1.0
Hydroxypropyl methylcellulose 1.0
Fine powder sorbitol 5.0
Alpinia bonito extract of Production Example 6 0.5
Fragrance 3.0
Residual amount of sodium sulfate 100

(Prescription Example 10) Ointment Weight%
l-Menthol 3.0
DL-Camphor 0.5
Alpinia bonito extract of Production Example 6 5.0
Propylene glycol 15.0
Carboxyvinyl polymer 1.0
Hydroxyethyl cellulose 0.1
Triethanolamine 0.7
Purified water 25.0
Remaining amount of ethanol 100

(Prescription Example 11) Patch%
l-Menthol 3.0
DL-Camphor 1.5
Polyacrylic acid 4.5
Sodium polyacrylate 1.5
Sodium carboxymethylcellulose 4.0
Alpinia bonito extract of Production Example 6 1.5
Glycerin 20.0
Sorbitol 5.0
Polyoxyethylene nonylphenyl ether 0.5
Kaolin 5.0
Castor oil 1.0
Purified water remaining The above-mentioned components dissolved, dispersed and kneaded were spread on a polyester non-woven fabric so as to be 1000 g per 1 m ² to produce a patch.

Path diagram of signals involving mTOR

Claims (1)

  A formulation used for activating mTOR, comprising at least one selected from a cowpea extract, an Ibukitorano extract, a gossip strawberry extract, a white willow extract, a red pepper extract and an Alpinia katsudai extract A preparation comprising an extract as an active ingredient.

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