JP5210786B2 - Agent for suppressing hair growth or hair growth - Google Patents

Description

  The present invention relates to a drug for suppressing hair growth or hair growth, and more particularly to a drug for suppressing hair growth or hair growth containing sorghum extract as an active ingredient.

  Conventionally, various hair growth agents, hair nourishing agents, and hair loss prevention agents have been developed and sold to treat or improve alopecia caused by side effects such as male pattern alopecia, juvenile alopecia, and anticancer agents. Various hair removal agents, hair growth inhibitors, hair growth to improve or improve aesthetic appearance by treating or improving hirsutism, or reducing body hair (arms, legs, wrinkles, face, pubic area, etc.) other than head hair Drugs and the like that suppress this have been proposed. For example, as a hair growth inhibitory component, an extract of a plant such as an armature extract, a hydrangea extract (see Patent Document 1), an extract of Chung Yin Jin or Caronin (see Patent Document 2), Hokoshitsu, Gobaishi, Diou, etc. (See Patent Document 3), extracts of plants such as sanjico, cyte, turmeric (see Patent Document 4), phosphonic acid derivatives (see Patent Document 5), steroids and their derivatives (see Patent Document 6), gallic acid esters , Capsaicin, methyl nicotinate, vitamin A (see Patent Document 7) and the like have been reported.

JP 2000-53538 A Japanese Patent Laid-Open No. 5-25027 JP-A-8-81336 Japanese Patent Laid-Open No. 10-139639 JP-A-11-199450 JP 2000-191459 A JP 2005-15410 A

  Moreover, as a component which suppresses hair growth, arginase inhibitors (such as a catechin compound (see Patent Document 8), α-aminoiso oxalic acid, 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide) Patent Document 9), hexonase inhibitors such as mannoseamine and 6-amino-6-deoxyglucose (see Patent Document 10), Echinakea and nasturtium extract (see Patent Document 11), Oat, Rice bran, Mulberry, Ouren, Thyme An extract of a plant such as (see Patent Document 12) has been reported. However, the hair growth inhibiting component or the component inhibiting hair growth reported so far does not have the desired effect, and the development of a component having a higher hair growth inhibiting effect or hair growth inhibiting effect is required. Has been.

Japanese National Patent Publication No. 11-501036 JP 2000-501096 gazette Special Table 2000-501098 JP 2000-169333 A JP 2003-306415 A

  Accordingly, an object of the present invention is to develop a component having a hair growth inhibitory effect or a hair growth inhibitory effect that is superior to conventional hair growth inhibitory components or hair growth inhibitory components. The development of a drug for suppressing hair growth or suppressing hair growth.

  The present inventor found that the sorghum extract has an excellent hair growth inhibitory effect or hair growth inhibitory effect, and by using the sorghum extract as an active ingredient, the sorghum extract suppresses hair growth superior to conventional ones or the hair growth. It came to develop the medicine for suppressing growth. As a well-known technique regarding sorghum extract so far, the flavilium compound extracted from sorghum stems, seeds, and leaves can be used as a coloring agent for artificially coloring the skin (see Patent Document 13), Use of starch contained in sorghum to prevent skin aging by preventing contaminants from adhering to keratin materials (see Patent Document 14), makeup containing sorghum stem or chip extract Excellent whitening effect (see Patent Document 15), sorghum bran and other parts, bran husk or endothelium, or whole plant extract has immunomodulating activity, allergic inhibitory activity, anticancer activity and elimination of active oxygen It has activity (see Patent Document 16), and the sorghum powder extract has blood lipid concentration lowering function and antioxidant function (patent text) 17) is reported, but it is a completely new finding that the sorghum extract, which is the main part of the present invention, has an excellent hair growth inhibitory effect or hair growth inhibitory effect, and is a well-known technique. Create a drug that suppresses hair growth or suppresses hair growth using sorghum extract as an active ingredient, which is different from various foods, pharmaceuticals, cosmetics, or specific drugs related to the reported sorghum extract It is.

JP 2002-104933 A JP 2002-241218 A JP 63-135310 A JP 2007-254338 A JP 2001-328944 A

  The drug of the present invention has an excellent hair growth inhibiting effect or hair growth inhibiting effect. By using this drug, treatment or improvement of hirsutism, or suppression of hair growth or growth of body hair (arms, legs, wrinkles, face, genital area, etc.) other than head hair, especially hair removal treatment or hair removal treatment or It is possible to effectively suppress the generation and growth of waste hair such as arms, legs, wrinkles, and faces after shaving treatment, and easily maintain a desired aesthetic appearance.

  The sorghum extract used as an active ingredient in the medicament of the present invention is a sorghum sorghum (Sorghum bicolor L. or Sorghum vulgare Pers., Also known as sorghum) or sorghum (Sorghum saccharatum) flower, stem, leaf, branch, At least one or more sites selected from seeds, roots, or whole plants are extracted as they are or after pulverization with a solvent. From the viewpoint of easy availability, it is preferable to use seeds, and from the viewpoint of extraction efficiency, finely pulverized ones are preferable.

  As an extraction solvent for obtaining the sorghum extract used in the present invention, water, lower alcohol such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol or the like, hydrous lower alcohol, propylene glycol, 1,3-butylene glycol 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,3,5-pentane Polyols such as triol, glycerin, polyethylene glycol (molecular weight 100 to 100,000) or hydrous polyhydric alcohols, acetone, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, tetrachloride Carbon, phenol, true From various organic solvents such as acids, acids (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.) that have been appropriately adjusted 1 type or 2 types or more selected are mentioned, and it is particularly preferable to select 1 type or 2 types or more selected from lower alcohols such as water, ethanol, propyl alcohol, isopropyl alcohol, butanol and isobutanol. However, if it is not preferable to use a solvent depending on the application, use water alone or extract with a highly volatile solvent that is easy to remove the solvent after extraction and dissolve in water after removing the solvent. Such a method is also possible.

  The extraction method is not particularly limited with respect to the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time. Specifically, the temperature of the solvent can be arbitrarily set within the range of -4 ° C to 100 ° C. From the viewpoint of the stability of the components contained therein, the vicinity of 10 to 40 ° C. is preferable. Further, the weight ratio of the solvent to the raw material can be arbitrarily set within the range of the raw material: solvent: 4: 1 to 1: 100, and particularly the weight ratio of 1: 1 to 1:20. preferable. About extraction time, the extraction period of 3 to 24 days is normally required.

  The sorghum extract used in the present invention includes those subjected to appropriate purification after solvent extraction within the scope of the definition. Specifically, purification operations include decomposition by adding acid (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, organic acid, etc.) or alkali (sodium hydroxide, calcium hydroxide, ammonia, etc.), fermentation or metabolic conversion by microorganisms, Fractionation using chromatography with ion-exchange resin, activated carbon, diatomaceous earth and other component adsorption, and various separation modes (ion exchange, hydrophilic adsorption, hydrophobic adsorption, size exclusion, ligand exchange, affinity, etc.) , Filtration using filter paper, membrane filter, ultrafiltration membrane, etc., pressurization or depressurization, heating or cooling, drying, pH adjustment, deodorization, decolorization, long-time storage, etc. It is possible to select and combine the processes.

  In producing the drug of the present invention, the shape of the sorghum extract used may be any shape such as liquid, solid, powder, paste, etc., and an optimum shape for carrying out the present invention is appropriately selected. select.

  The drug of the present invention is composed of a sorghum extract which is an active ingredient only, and other ingredients acceptable for constituting the drug (for example, carriers, excipients, disintegrants, Buffers, emulsifiers, suspending agents, soothing agents, stabilizers, preservatives, preservatives, physiological saline, organic solvents, etc.) are also included within the scope of the definition. The dosage form of the drug is not particularly limited as long as it is a dosage form suitable for external use. Capsule, powder, granule, solid, liquid, gel, foam, emulsion, cream, ointment, sheet , Mousse, powder dispersion, multilayer, aerosol, and the like. Content of the sorghum extract in the chemical | medical agent of this invention is the range of 0.01-100 mass%, Preferably it is the range of 1-50 mass%.

  The agent of the present invention is further used as an additive component for attaching a hair growth suppressing effect and a hair growth suppressing effect to cosmetics and quasi drugs. Specifically, as cosmetics, a hair removal agent such as paste, cream or aerosol, a hair removal agent such as wax, gel or sheet, a lotion or cream used for hair removal or hair removal post-treatment, etc. Post-treatment fees, pre-shaving pre-shaving treatments, shaving cream shavings, after-shaving post-shaving treatments, face wash, soap, body shampoo, etc. Used in an antiperspirant. In addition, as a quasi-drug, it is used in combination with ointments, patches, lotions, poultices, liniments and the like. Content of the chemical | medical agent of this invention in cosmetics and quasi-drugs is the range of 0.001-50 mass%.

  In cosmetics or quasi-drugs containing the drug of the present invention, in addition to the drug containing the essential sorghum extract as an active ingredient, various ingredients exemplified below may be arbitrarily selected and added as additives. Thus, it is possible to attach various functions. The content of various components in cosmetics or quasi drugs is not particularly limited, but is usually set in the range of 0.0001 to 75% by weight.

Pigmentation inhibitor A pigmentation inhibitor can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of pigmentation inhibitors include p-aminobenzoic acid derivatives, salicylic acid derivatives, benzenesulfonamide derivatives, imidazole derivatives, naphthalene derivatives, hydroxyanthranilic acid or salts thereof, and derivatives thereof, anthranilic acid derivatives, coumarin derivatives, amino acids Derivatives (2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid, 2-amino-3- [1-carboxyl-2- (1H-imidazole) -4-yl) ethyl] aminobutanoic acid hydrochloride, 2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid sodium salt, 2-amino-3- [ 1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid potassium salt, etc.), benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor Derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, ascorbic acid or salts thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyprosthelic acid) Phosphorus phosphate, 5-o-α-D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L -Ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbine Acid sulfate ester calcium salt, L-ascorbate sulfate aluminum salt, L-ascorbate sodium salt, L-ascorbate potassium salt, L-ascorbate magnesium salt, L-ascorbate calcium salt, L-ascorbate aluminum salt, 6-o-α-D-galactopyranosyl-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid Phosphate sodium salt, L-ascorbic acid sulfate sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphoric acid Ester isopropanolamine salt, 3-o-isopropyl-L-ascorbic acid, 6-o-alkylascorbic acid phosphate Tellurium salt, 6-o-alkylascorbic acid phosphate calcium salt, 6-o-alkylascorbic acid phosphate barium salt, 6-o-alkylascorbic acid phosphate ammonium salt, 6-o-alkylascorbic acid Phosphate monoethanolamine salt, 6-o-alkylascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt 6-o-alkylascorbic acid phosphate diisopropanolamine salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D- Galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate cholesterol Ester, palmitic acid-L-ascorbyl, isopalmitic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid -L-ascorbyl, diisostearic acid-L-ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid- L-ascorbyl, di-2-ethylhexanoic acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L -Ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid , 2-o-α-D- Lutotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitate, L-ascorbic acid tetralaurate, L-ascorbate tetra-2-ethylhexanoate, L-ascorbate tetraoleate, 5, 6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbine Acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl cinna Pate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxyferrate, DL-α- Coferol-2-L-ascorbic acid phosphoric diester, ascorbic acid inositol binding derivative, ascorbic acid phosphoramide derivative, ascorbyl arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative, etc.), tocopherol or its Salts and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol Acetate, tocopherol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucosi DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl Glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-toco Ferryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β- Tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- ( Sulfoethylamino) -3- (α-toco Eleyl-6-Iroxy) propan-2-ol, 1- (Carboxypropylamino) -3- (α-tocopheryl-6-Iroxy) propan-2-ol hydrochloride, S- [3- (α-Toco Ferroyl-6-iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof And derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol Orotate), kojic acid or its derivatives (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoyloxymethyl-5 -Hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one, kojic acid Glucose, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate , Kojic acid dioleate, etc.), oxybenzone, benzophenone, guaiazulene, shikonin, baicalin or a salt thereof and derivatives thereof Baicalein or a salt thereof and derivatives thereof, berberine or a salt thereof and derivatives thereof, chrysin or a salt thereof and derivatives thereof, apigenin or a salt thereof and derivatives thereof, luteolin or a salt thereof and derivatives thereof, acetetine or a salt thereof and Derivatives thereof, diosmethine or a salt thereof and derivatives thereof, kaempferol or a salt thereof and derivatives thereof, triphorin or a salt thereof and derivatives thereof, astragalin or a salt thereof and derivatives thereof, quercetin or a salt thereof and derivatives thereof Quercitrin or a salt thereof and derivatives thereof, isoquercitrin or a salt thereof and derivatives thereof, rutin or a salt thereof and derivatives thereof, morin or a salt thereof and derivatives thereof, myricetin or a salt thereof And derivatives thereof, myristitrin or a salt thereof and derivatives thereof, dachiscetin or a salt thereof and derivatives thereof, quercetagetin or a salt thereof and derivatives thereof, isorhamnetin or a salt thereof and derivatives thereof, pinocembrin or a salt thereof and derivatives thereof Naringenin or a salt thereof and derivatives thereof, hesperetin or a salt thereof and derivatives thereof, eriodictyol or a salt thereof and derivatives thereof, pinobankin or a salt thereof and derivatives thereof, aromadendrin or a salt thereof and derivatives thereof, Engeritin or a salt thereof and derivatives thereof, taxofolin or a salt thereof and derivatives thereof, astilbine or a salt thereof and derivatives thereof, amperopsin or a salt thereof and derivatives thereof, Spira Oside, kaempferol-7-neohesperidoside, glutathione or salts thereof and derivatives thereof, isoflavone glycosides (6-o-apiosyl puerarin-4'-o-glucoside, 6-o-glucosyl puerarin, 3 '-Hydroxypuerarin-4'-o-glucoside,6-o-apiosyl-3'-hydroxypuerarin, etc.), γ-pyrone glycoside (maltol-3-o- (6'-o-apiosyl) -glucoside, maltol -3-o- (6′-o-apiosyl) -glucoside etc.), isononyl ferrate, ellagic acid or its salts and derivatives thereof (5,4-dimethylellagic acid, 3,3′-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-methoxyellagic acid, 3-ethyl-4-methyl-5-hydroxyellagic acid, amritoside, etc.), lucinol, Onji Saponin, Bacmond Saponin, Ruscogenin, Celicoside, Asian Chicoside Hederin, senegin, benzoic acid anilides (4-hydroxy-N- (2-hydroxyphenyl) benzoic acid amide, 4-hydroxy-N- (3-hydroxyphenyl) benzamide, 4-hydroxy-N- (4-hydroxyphenyl) ) Benzamide, 3,5-di-t-butyl-4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N- (3-hydroxyphenyl) benzamide , 3,5-di-t-butyl-4-hydroxy-N- (2-hydroxyphenyl) benzamide, etc.), diphenylpyralin, cyproheptadine, triprolysine, dimethindene, ozagrel, istipendyl, iproheptin, homochlorcyclidine, alimemazine, Bucillamine, oxytosamide, vidarabine, xanthotoxol, phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide, fetus (Bovine-derived, porcine-derived, horse-derived, sheep-derived, etc.) extract, almond extract, amaranth extract, octopus extract, lobster extract, okera extract, kofuyou extract, uncaria extract, gaija extract, kako Juyou Extract, Licorice Extract, Gardenia Extract, Kranigean Extract, Clara Extract, Koganebana (Ogon) Extract, Wheat (Wheat) Extract, Rice (Rice) Extract, Korealia Extract, Sidwaya Extract, Sunku Kyu Extract, San Vitro Extract, Sunpens extract, Silane (Biacaria) extract, Senkyu (river cucumber) extract, Senna extract, Sempukuka extract, Sentsutsusai extract, Surigatin extract, Nodake (former cucumber) extract, pearl barley (Yokuinin) extract, Vulture extract, Honey beetle , Hamamelis extract, palm extract, parietalia extract, safflower (safflower) extract, mugwa (mulberry white skin) extract, malvanojadine (bitter) extract, purple squirrel extract, white squirrel extract, mugwort extract, yashajitsu extract, hongkong Examples include an extract, a bitter melon extract, a quail extract, a citrus extract, and a millipede extract.

Tyrosinase activity inhibitor A tyrosinase activity inhibitor can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of tyrosinase activity inhibitors include ascorbic acid or salts thereof and derivatives thereof (magnesium phosphate-L-ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyprophosphate phosphate ascorbate, 5-o-α -D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid Sulfate Stell aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyrano Sil-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Ester sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl- L-ascorbic acid, 6-o-alkylascorbic acid potassium ester potassium salt, 6-o-alkylascorbic acid phosphate Steal calcium salt, 6-o-alkyl ascorbic acid phosphate barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o-alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl Ascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanol Amine salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, phosphorus ascorbate Acid cholesterol ester, palmitic acid-L-ascorbyl, isopa Mycinic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid-L-ascorbyl, diisostearic acid-L- Ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid-L-ascorbyl, di-2-ethylhexane Acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α- D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-malto Triosyl-L-ascorbic acid, L-ascorbic acid Trisopalmitic acid ester, L-ascorbic acid tetralauric acid ester, L-ascorbic acid tetra-2-ethylhexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, L- Ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbyl triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl cinnamate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphoric acid diester, Scorbic acid inositol binding derivative, ascorbic acid phosphoramide derivative, ascorbic acid arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative, etc.), hydroquinone or its salts and derivatives thereof (hydroquinone α-D-glucose , Hydroquinone β-D-glucose, hydroquinone α-L-glucose, hydroquinone β-L-glucose, hydroquinone α-D-galactose, hydroquinone β-D-galactose, hydroquinone α-L-galactose, hydroquinone β-L-galactose, etc. Hexoses, hydroquinone α-D-ribose, hydroquinone β-D-ribose, hydroquinone α-L-ribose, hydroquinone β-L-ribose, hydroquinone α-D-arabinose, hydroquinone β-D-a Five carbon sugar glycosides such as rabinose, hydroquinone α-L-arabinose, hydroquinone β-L-arabinose, hydroquinone α-D-glucosamine, hydroquinone β-D-glucosamine, hydroquinone α-L-glucosamine, hydroquinone β-L- Amino sugar glycosides such as glucosamine, hydroquinone α-D-galactosamine, hydroquinone β-D-galactosamine, hydroquinone α-L-galactosamine, hydroquinone β-L-galactosamine, hydroquinone α-D-glucuronic acid, hydroquinone β-D- Glucuronic acid, hydroquinone α-L-glucuronic acid, hydroquinone β-L-glucuronic acid, hydroquinone α-D-galacturonic acid, hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, hydroquinone β-L-galacturonic acid Hydroquinone glycosides such as uronic acid glycosides Hydroquinone benzyl ether, 4-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) butane, 5-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) pentane, 6- β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) hexane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propane, 2-β-D-glucopyra Hydroquinone hydroxyalkyl ether glycosides such as nosyloxy-1- (4-hydroxyphenoxy) butane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propan-3-ol, etc.) Kojic acid or a salt thereof and derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoyloxymethyl- 5-Hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hy Droxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate , Kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.), tocopherol or a salt thereof and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate Tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ- Tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β -Tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L- α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ- Coferyl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, L- (sulfoethylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol, 1 -(Carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] Cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2 -Hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate , Tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate, etc.), N-acetyltyrosine or a salt thereof and derivatives thereof, glutathione or a salt thereof and derivatives thereof, ellagic acid or a salt thereof and derivatives thereof (3,4-dimethylellagic acid, 3,3'-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-methoxyellagic acid, 3- Ethyl-4-methyl-5-hydroxyellagic acid, amritosides, etc.), isonitrine A, isonitrine B, isonitrine C, isonitrin D, isonitrinic acid E, isonitrinic acid F, dermadein, tricobylidein and other isonitrile antibiotics, orthoric acid derivatives (Orceric acid, orceric acid ethyl ester orcinol, p-geranylorceric acid, p-gerani Orceric acid ethyl ester geranyl orcinol, p-farnesylorceric acid, p-farnesylorceric acid ethyl ester farnesylorcinol, p-dodecanylorceric acid, p-dodecanylorceric acid ethylester dodecanylorcinol, p -Tetradecanylorceric acid, p-tetradecanylorceric acid ethyl ester tetradecanylorcinol, p-hexadecanylorceric acid, p-hexadecanylorceric acid ethylester hexadecanylorcinol, p -Undecanylorceric acid, p-undecanylorceric acid ethyl ester undecanylorcinol, p-tridecanylorceric acid, p-tridecanylorceric acid ethylester undecanylorcinol, p-penta Decanylorceric acid, p-pentadecanylorserine Ethyl ester pentadecanylorcinol, ethylhexylorceric acid, p-ethylhexylorceric acid ethylester ethylhexylorcinol, p-cyclohexylmethylorceric acid, p-cyclohexylmethylorceric acid ethylester cyclohexylmethylorcinol, p-hydroxy Ethyl hexylorceric acid methyl ester, p-hydroxyethylhexylorceric acid hydroxyethylhexylorcinol, etc.), umbelic acid, brefeldin, oxydesveratrol, resorcinol derivative (4-cyclohexylresorcinol), 3-hydroxyketone compound (1, 5-bis (p-hydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (o, p-dihydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (p- Hydroxyphenyl-m-meth Ciphenyl) -2-hydroxypentan-4-one), 1,3-diketone compounds (1,5-bis (p-hydroxyphenyl) -2,4-pentanedione, 1,5-bis (o, p- Dihydroxyphenyl) -2,4-pentanedione, 1,5-bis (p-hydroxyphenyl-m-methoxyphenyl) -2,4-pentanedione, etc.), bishydroxybenzylamides, γ-aminobutyric acid or derivatives thereof (N-methyl-γ-aminobutyric acid, N-dimethyl-γ-aminobutyric acid, γ-aminobutyric acid oleyl ester, etc.), hydrogen peroxide, zinc peroxide, placenta extract, lucinol, silk extract, acacia extract, acerola extract, Ichibi (winter position) extract, Weeping birch extract, Quercus extract, Chestnut extract, Tortoise extract, Tobacco extract, Tobacco extract, Seri extract, Buckwheat extract, Davilia extract, Nazuna extract, F Zibakama (Orchid) extract, Chamomile extract, Mulberry extract, Gardenia extract, Japanese cypress extract, Walnut extract, Clara extract, Mugwort extract, Honeysuckle extract, Yellowfin extract, Dokudami extract, Matsuhodo extract, Pearl barley extract, Odorikosou extract, Hop extract, Hawthorn extract, Eucalyptus Extract, Achillea millefolium extract, Altea extract, Keihi extract, Mantis extract, Hamamelis extract, Yamaguchi extract, bellflower extract, Toshishi extract, Zyoko extract, Shoot dried extract, Mao extract, Senkyu extract, Dokatsu extract, Psycho extract, Bow extract, Hamaboufu Extract, Ogon extract, Peony skin extract, Peonies extract, Gennoshoco extract, Kudzu root extract, Licorice extract, Pyramid extract, Aloe extract, Shouma extract Safflower extract, green tea extract, black tea extract, include Uncaria gambir Roxburgh extract, and the like.

Melanocyte melanin production inhibitor A melanocyte melanin production inhibitor can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of melanocyte melanin production inhibitors include lobeline or lobeline derivatives, liquiritin derivatives (such as liquiritin-α-glucoside, liquiritin-α-maltoside), phenylchroman derivatives, chromone derivatives (2-butylchromone, 2-pentylchromone, 2 -Heptylchromone, 2-nonylchromone, 2-hexadecylchromone, 2- (1-ethylpentyl) chromone, 2-butyl-7-methoxychromone, 2-pentyl-7-methoxychromone, 2-heptyl-7-methoxychromone 2-nonyl-7-methoxychromone, 2-pentadecyl-7-methoxychromone, 2- (1-ethylpentyl) -7-methoxychromone, 7-hydroxy-2-methylchromone, 7-hydroxy-2-butylchromone 7-hydroxy-2-pentylchromone, 7-hydroxy-2-heptylchromone, 7-hydroxy-2-nonylchromone, 7-hydroxy-2-penta Desylchromone, 7-hydroxy-2- (1-ethylpentyl) chromone), azelaic acid derivatives (azelaic acid monoalkyl ester, azelaic acid dialkyl ester, etc.), phosphatidylglucosamine, lysophosphatidylglucosamine, phenylhydroquinone, 3-β-D -Glucopyranosyl manur, 3-β-D-maltopyranosyl manur, substituted amino acid derivatives (DL-N-formyl-3- (1-naphthyl) alanine, DL-N-acetyl-3- (1-naphthyl) ) Alanine, DL-N-propionyl-3- (1-naphthyl) alanine, DL-N-butyryl-3- (1-naphthyl) alanine, DL-N-isobutyryl-3- (1-naphthyl) alanine, DL- N-valeryl-3- (1-naphthyl) alanine, DL-N-isovaleryl-3- (1-naphthyl) alanine, DL-N- (2-methylvaleryl) -3- (1-naphthyl) alanine, DL-N -(3-Methylvaleryl) -3- (1-naphthyl) alanine, DL-N- (4-Methylvaleryl) -3- (1 -Naphthyl) alanine, DL-N-t-butylacetyl-3- (1-naphthyl) alanine, DL-N-pivaloyl-3- (1-naphthyl) alanine, DL-N-caproyl-3- (1-naphthyl) ) Alanine, DL-N- (2-ethylhexanoyl) -3- (1-naphthyl) alanine, DL-N- (2-methylhexanoyl) -3- (1-naphthyl) alanine, DL-N-heptanoyl -3- (1-naphthyl) alanine, DL-N-octanoyl-3- (1-naphthyl) alanine, DL-N- (2-propylpentanoyl) -3- (1-naphthyl) alanine, DL-N- Nonanoyl-3- (1-naphthyl) alanine, DL-N-decanoyl-3- (1-naphthyl) alanine, DL-N-undecanoyl-3- (1-naphthyl) alanine, DL-N-dodecanoyl-3- ( 1-naphthyl) alanine, DL-N-tridecanoyl-3- (1-naphthyl) alanine, DL-N-tetradecanoyl-3- (1-naphthyl) alanine, DL-N-pentadecanoyl-3- (1 -Naphthyl) alanine, DL-N-hexadecanoyl-3- (1-naphthyl) alanine DL-N-heptadecanoyl-3- (1-naphthyl) alanine, DL-N-octadecanoyl-3- (1-naphthyl) alanine, DL-N-nonadecanoyl-DL-3- (1-naphthyl) alanine, DL -N-icosanoyl-3- (1-naphthyl) alanine, DL-N-acryloyl-3- (1-naphthyl) alanine, DL-N-crotoniloyl-3- (1-naphthyl) alanine, DL-N-methacryloyl- 3- (1-naphthyl) alanine, DL-N-vinylacetyl-3- (1-naphthyl) alanine, DL-N-cyclopropanoyl-3- (1-naphthyl) alanine, DL-N- (2-pentenoyl ) -3- (1-naphthyl) alanine, DL-N- (4-pentenoyl) -3- (1-naphthyl) alanine, DL-N- (2-hexenoyl) -3- (1-naphthyl) alanine, DL -N- (3-hexenoyl) -3- (1-naphthyl) alanine, DL-N- (2-methyl-3-pentenoyl) -3- (1-naphthyl) alanine, DL-N-cyclohexenoyl -3- (1-naphthyl) alanine, DL-N- (10-undecenoyl) -3- (1-naphthyl) alanine, D LN-linoleyl-3- (1-naphthyl) alanine, DL-N-hydroxyacetyl-3- (1-naphthyl) alanine, DL-N- (6-hydroxycaproyl) -3- (1-naphthyl) alanine, DL-N- (8-hydroxyoctanoyl) -3- (1-naphthyl) alanine, DL-N- (9-hydroxynonanoyl) -3- (1-naphthyl) alanine, DL-N- (10-hydroxy Decanoyl) -3- (1-naphthyl) alanine, DL-N- (11-hydroxyundecanoyl) -3- (1-naphthyl) alanine, DL-N- (12-hydroxydecanoyl) -3- ( 1-naphthyl) alanine, DL-N-benzoyl-3- (1-naphthyl) alanine, DL-N- (2-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-hydroxybenzoyl ) -3- (1-naphthyl) alanine, DL-N- (4-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (o-toluyl) -3- (1-naphthyl) alanine, DL-N- (m-Toluyl) -3- (1-naphthyl) alanine, DL-N- (p-Toluyl) -3- (1-naphthyl) ara DL-N- (1-naphthyl) -3- (1-naphthyl) alanine, DL-N- (2-naphthyl) -3- (1-naphthyl) alanine, DL-N- (2-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (4-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (2-picoline) -3- (1-naphthyl) alanine, DL-N- (3-picoline) -3- (1-naphthyl) alanine, DL-N- (4-picoline) -3- (1-naphthyl) alanine, DL-N-phenylacetyl-3- (1-naphthyl) alanine, DL-N- (2-phenylpropanoyl) -3- (1-naphthyl) alanine, DL-N- (3 -Phenylbutyryl) -3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine, DL-N-valeryl-3- (1-naphthyl) alanine, DL -N- (4-methylvaleryl) -3- (1-naphthyl) alaninamide, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine methyl ester DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine ethyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine propyl ester, DL-N- (4-methylvaleryl ) -3- (1-naphthyl) alanine-N-butyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine pentyl ester, DL-N- (4-methylvaleryl) -3- ( 1-naphthyl) alanine isopropyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine isobutyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine-t- Butyl ester, etc.), benzolactam derivatives, indolactam derivatives, cedrol, guaiool, 1- (4-hydroxyphenthio) -2-propanol, β-lactoglobulin, 2-methoxy-5-methylphenol, 5-ethyl-2 -Methoxyphenol, 5-N-propyl-2-methoxyphenol, 5-N-butyl-2-methoxypheno 5-N-hexyl-2-methoxyphenol, 5-N-heptyl-2-methoxyphenol, 5-N-decyl-2-methoxyphenol, 5- (1,1-dimethylpropyl) -2-methoxy Phenol, 5- (1,1-dimethylbutyl) -2-methoxyphenol, 5- (1,1-dimethylethyl) -2-methoxyphenol, 2-methoxy-5- (1-methylpentyl) phenol, 2- Methoxy-5- (1-methylhexyl) phenol, 2-methoxy-5- (3-methylhexyl) phenol, 2-methoxy-5- (6-methylheptyl) phenol, 5- (1,3-dimethylheptyl) -2-Methoxyphenol, malvelin, ferguinol, sugiol, cryptojaponol, 1,5-bis [p-hydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [o-hydroxyphenyl]- 1,4-pentadien-3-one, 1,5-bis [2,4-dihydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [3-mes Xyl-4-hydroxyphenyl] -1,4-pentadien-3-one, haginin, agrimophor, agrimol, hydrangenol or derivatives thereof, alkylresorcinol or derivatives thereof (such as 4-N-butylresorcinol), aristrone, Caramenenes (such as caramenene, 7-hydroxycaramenene, 5-hydroxycaramenene, 7-methoxycaramenene), trans-umberic acid, N-α-benzoyl-L-arginine, N-α-benzoyl-L-arginine ethyl Ester or N-α-benzoyl-L-arginine ethyl ester, 5-methyl-2 (3H) -furanone, 2-butene-4-olide, 2-hydroxymethylfuran, 2,5-dimethyl-4-hydroxy-3 (2H) -furanone, 2-formylfuran, 3-formylfuran, methyl α-furyl ketone, furfuryl acetate, 2-hydroxy-3-methyl-2-cyclopenten-1-one, 2-hydroxy-3,5 -Dimethyl-2-cyclopenten-1-one, 2,5-dimethyl-4-hydroxy-3 (2H) -thiophenone, 2-hydroxy-3-ethyl-2-cyclopenten-1-one, tetronic acid, pentanedione, Iminodibenzyls (2,2'-iminodibenzyl, imipramine, imipramine hydrochloride, desipramine, desipramine hydrochloride, chlorimipramine, trimipramine, etc.), dibenzocycloheptadienes (amitriptyline, amitriptyline hydrochloride, nortriptyline, noxiptylline, etc.), Tetrahydrocopalol glycosides (ketotifen fumarate, labda-8 (17), 13-dien-15-ol, tetrahydromanur, tetrahydrocoparol, tetrahydrocoparol glucoside, tetrahydrocoparol galactoside, tetrahydrocoparol maltoside, Tetrahydrocoparol cellobioside, Tet Lahydrocopalol maltotrioside, etc.), spiro ether compound, piochelin, phenothiazine compound, promethazine, alimemazine, alimemazine tartrate, triflupromazine, levomepromazine, chlorpromazine, cyclandrate, 4-carboxymethyloxybenzoic acid, 4-carboxymethyl Oxy-2-hydroxybenzoic acid, 3- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) benzoic acid, 4- (3-carboxypropyl- 1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-methoxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4 -(5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1 -Oxy) -2-hydroxybenzoic acid, 4- (10-carbamoyldecane-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) benzoic acid, 4- (4-hydroxy Butyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-acetoxybutyl-1-oxy) benzoic acid, 4- (4-acetoxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- ( 3-Ethoxycarbonylpropyl-1-oxy) -2-hydroxybenzoic acid, 3- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-methoxybutyl-1-oxy) 2-hydroxybenzoic acid, 4- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3- (3-carboxypropyl-1- Oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxy Benzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1 -Oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid, hydroxytrimethylcyclohexanes (2-hydroxy-4- (2,2,6-trimethyl-1) -Yl-cyclohexane) butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -1-butene, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2-butene 4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 3-methyl-3-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl -1-Hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl -1-Hydro Ci-5- (2,2,6-trimethyl-1-yl-cyclohexane) -3-pentene, 3-methyl-3-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane)- 1-pentene, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -2-pentene, 2-hydroxy-4- (2,2,6-trimethyl-1 -Mono-, di- or trisaccharide glycosides such as -yl-cyclohexane) butane), escinol, parahydroxycinnamic acid-4- (2,2,6-trimethyl-yl-cyclohexane) -2-butyl ester Monosaccharide, disaccharide or trisaccharide glycoside, ondisaponin, bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin, senegin, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2 -Keto-butane, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto-butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2 -Keto-3-butene, 4- (2,2 , 6-Trimethyl-1-yl-6-cyclohexene) -2-keto-3-butene (β-ionone)
, Lp-hydroxyphenylglycine, Dp-hydroxyphenylglycine, N-benzyloxycarbonyl-Lp-hydroxyphenylglycine, N-benzyloxycarbonyl-Dp-hydroxyphenylglycine, N-benzoyl-Lp-hydroxyphenylglycine, N-benzoyl -Dp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Dp-hydroxyphenylglycine, N- (p-hydroxybenzoyl) -Lp-hydroxyphenyl Glycine, N- (p-hydroxybenzoyl) -Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine, N-acetyl-Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine ethyl ester, N -Acetyl-Dp-hydroxyphenylglycine ethyl ester, N-acetate -Lp-hydroxyphenylglycinamide, N-acetyl-Dp-hydroxyphenylglycinamide, Lp-methoxyphenylglycine, Dp-methoxyphenylglycine, Lp-methoxyphenylglycine hydrochloride, Dp-methoxyphenylglycine hydrochloride, 4- Hydroxy-3-methoxy-L-phenylglycine, 4-hydroxy-3-methoxy-D-phenylglycine, Lp-hydroxyphenylglycine ethylamide, Dp-hydroxyphenylglycine ethylamide, N-tert-butoxycarbonyl-Lp-hydroxy Phenylglycine, N-tert-butoxycarbonyl-Dp-hydroxyphenylglycine, N-tert-butoxycarbonyl-Lp-methoxyphenylglycine, N-tert-butoxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyl Oxycarbonyl-Lp-methoxyphenylglycine, N-9-fluoreni Methyloxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxyphenylglycine benzyl ester hydrochloride, N-9-fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine benzyl ester hydrochloride Salt, Lp-hydroxyphenylglycinamide, Dp-hydroxyphenylglycinamide, Lp-hydroxyphenylglycine allyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine allyl ester p-toluenesulfonate, Lp-hydroxyphenylglycine benzyl Ester p-toluenesulfonate, Dp-hydroxyphenylglycine benzyl ester p-toluenesulfonate, Lp-hydroxyphenylglycine ethyl ester, Dp-hydroxyphenylglycine ethyl ester, Lp-hydroxyphenyl Nylglycine ethyl ester hydrochloride, Dp-hydroxyphenylglycine ethyl ester hydrochloride, Lp-hydroxyphenylglycine methyl ester, Dp-hydroxyphenylglycine methyl ester, 1,3-diallylindane-2-carboxylic acids, stachybosines, pheophorbide Derivatives, eleucerin, isoeleucerine or 4-β-hydroxyisoeleucerin, eleucerinol, spiroketal derivatives (2- (2,4-hexadinylidene) -1,6-dioxaspiro [4.5] dec-3-ene, 2- (2-hexynylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-((4-methylphenyl) methylidene) -6,6-dioxaspiro [4.4] non-3-ene, 2- (2 -Hexenylidene) -6,6-dioxaspiro [4.5] dec-3-ene, 2- (2-hexenylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-hexyl-1,6-dioxaspiro [ 4.4] Nonane, 2- (2-F Xenyl) -1,6-dioxaspiro [4.4] nonane, 2- (2-hexynyl) -1,6-dioxaspiro [4.4] nonane, 2-pentyl-1,6-dioxaspiro [4.4] nonane, 1,6-dioxaspiro [4.4] nonane, 1,6-dioxaspiro [4.5] decane, 1,7-dioxaspiro [5.5] undecane, 2,3-benzo-4,4-dimethyl-1,6-dioxaspiro [4.4] nonane, 3,4 -Benzo-2-pentyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-hexyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-octyl-1,6 -Dioxaspiro [4.4] nonane, 2-hexyl-9,9-dimethyl-1,6-dioxaspiro [4.4] nonane, 2- (2,4-hexadiynylidene) -1,6-dioxaspiro [4.4] nona-3 -Ene etc.), malvalic acid, phosphonic acid derivative or salt thereof, aspergillomarasmin, aminophosphonic acid derivative or salt thereof, diphenhydramine or salt thereof, pregnenolone or derivative thereof, Thein, farnesyl isopropanol derivative, hexahydrofarnesyl acetone, 4-benzoylamino-2-hydroxybenzoic acid, 5-benzoylamino-2-hydroxybenzoic acid, 4-benzoylaminobenzoic acid, 4- (1-naphthoylamino)- 2-hydroxybenzoic acid, 5- (1-naphthoylamino) -2-hydroxybenzoic acid, 4- (2-naphthoylamino) -2-hydroxybenzoic acid, 5- (2-naphthoylamino) -2- Hydroxybenzoic acid, 4- (1-naphthoylamino) benzoic acid, 4- (2-naphthoylamino) benzoic acid, 4-phenylaminocarbonylbenzoic acid, 4-phenylaminocarbonyl-2-hydroxybenzoic acid, 5- Phenylaminocarbonyl-2-hydroxybenzoic acid, 4- (1-naphthylaminocarbonyl) benzoic acid, 4- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (1-naphthylaminocarbonyl) -2- Hydro Cibenzoic acid, 4- (2-naphthylaminocarbonyl) benzoic acid, 4- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, hexahydro Farnesyl isopropanol derivatives, borneol-p-hydroxycinnamic acid glucoside, borneol-p-hydroxycinnamic acid maltoside, borneol-p-hydroxycinnamic acid maltotrioside, cinnamic acid-4- (2,2, 6-trimethyl-yl-cyclohexane) -2-butyl ester derivative, 2,4-dihydroxybenzophenone, 1- (2,4-dihydroxyphenyl) -ethanone (2 ', 4'-dihydroxyacetophenone), 1- (2, 4-Dihydroxyphenyl) -1-propanone (2 ', 4'-dihydroxypropiophenone), 1- (2,4-dihydroxyphenyl) -1-butanone, 1- (2,4-dihydroxyphenyl) -1- Bae Thanone, 1- (2,4-dihydroxyphenyl) -1-hexanone, 1- (2,4-dihydroxyphenyl) -1-heptanone, 1- (2,4-dihydroxyphenyl) -1-octanone, 1- ( 2,4-dihydroxyphenyl) -1-nonanone, 1- (2,4-dihydroxyphenyl) -1-decanone, 1- (2,4-dihydroxyphenyl) -1-undecanone, 1- (2,4-dihydroxy Phenyl) -1-dodecanone, 1- (2,4-dihydroxyphenyl) -1-tetradecanone, 1- (2,4-dihydroxyphenyl) -1-hexadecanone, 1- (2,4-dihydroxyphenyl) -1- Octadecanone, 1- (2-hydroxy-4-methoxyphenyl) -ethanone (2'-hydroxy-4'-methoxyacetophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-propanone (2'-hydroxy -4'-methoxypropiophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-butanone, 1- (2-hydroxy-4-methoxyphenyl) -1-pentanone 1- (2-hydroxy-4-methoxyphenyl) -1-hexanone, 1- (2-hydroxy-4-methoxyphenyl) -1-heptanone, 1- (2-hydroxy-4-methoxyphenyl) -1- Octanone, 1- (2-hydroxy-4-methoxyphenyl) -1-nonanone, 1- (2-hydroxy-4-methoxyphenyl) -1-decanone, 1- (2-hydroxy-4-methoxyphenyl) -1 -Undecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-dodecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-tetradecanone, 1- (2-hydroxy-4-methoxyphenyl)- 1-hexadecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octadecanone, 1- (4-hydroxy-2-methoxyphenyl) -ethanone (4′-hydroxy-2′-methoxyacetophenone), 1- (4-hydroxy-2-methoxyphenyl) -1-propanone (4′-hydroxy-2′-methoxypropiophenone), 1- (2,4-dimethoxyphenyl) -ethane Non (2 ', 4'-dimethoxyacetophenone), 1- (2,4-dimethoxyphenyl) -1-propanone (2', 4'-dimethoxypropiophenone), lactone derivative (1,6-dioxaspiro [4.4] Nonane-2,7-dione, 1,6-dioxaspiro [4.5] decane-2,7-dione, 4-tridecanolide, 4-dodecanolide, 4-undecanolide, 4-decanolide, 4-nonanolide, 4-octanolide, 4- Heptanolide, 5-dodecanolide, 5-undecanolide, 5-decanolide, 5-nonanolide, 5-octanolide, 2-undecen-4-olide, 2-decen-4-olide, 2-nonene-4-olide, 2-heptene- 4-Olide, 2-Undecen-5-Olide, 2-Decene-5-Olide, 2-Nonene-5-Olide, 2-Octene-5-Olide, 4-Methyl-4-dodecanolide, 4-Methyl-4- Undecanolide, 4-methyl-4-decanolide, 4-methyl-4-nonanolide, 4-methyl-4-heptanolide, 5-methyl-5-dodecanolide, 5- Til-5-undecanolide, 5-methyl-5-decanolide, 5-methyl-5-nonanolide, 5-methyl-5-octanolide, 2-methoxycarbonyl-4-dodecanolide, 2-methoxycarbonyl-4-undecanolide, 2- Methoxycarbonyl-4-decanolide, 2-methoxycarbonyl-4-nonanolide, 2-methoxycarbonyl-4-heptanolide, 2-methoxycarbonyl-5-undecanolide, 2-methoxycarbonyl-5-decanolide, 2-methoxycarbonyl-5- Nonanolide, 2-methoxycarbonyl-5-octanolide, 2-allyl-4-undecanolide, 2-allyl-5-decanolide, 2-allyl-4-nonanolide, 2-pentyl-4-undecanolide, 2-pentyl-4-nonanolide 2-methyl-4-undecanolide, 2-methyl-4-nonanolide, 2- (4-hydroxybutyl) -4-undecanolide, 2- (4-hydroxybutyl) -4-nonanolide, 2- (4-hydroxybutyl ) -5-deca Lido, 5-propyloxy-4-pentanolide, 5-allyloxy-4-pentanolide, 5- (2-hydroxyethoxy) -4-pentanolide, 8-hydroxy-4-octanolide, 6-propyloxy-5-hexanolide, 6 -Allyloxy-5-hexanolide, 6- (2-hydroxyethoxy) -5-hexanolide, 9-hydroxy-5-nonanolide, etc.), ethinomycin, iriflorental, iriparidal, 2'-8-C-glucosyl-7- Methyl Aloesol Coumaroyl Ester, 2'-8-C-Glucosyl-7-Methyl Aloesol Cinnamoyl Ester, Chloropyramine, Anise Extract, Aloe Extract, Itadori Extract, Onibasiri Extract, Shrimp Extract, Ketsumeishi ) Extract, ogi (yellow cocoon) extract, yellow eagle extract, red-crowned cucumber (calocon) extract, onamomi (cow ear) extract, oninoyagara (Tempa) , Oyster extract, beetle extract, pumpkin extract, catfish extract, sweet squirrel extract, beetle extract (Sentsukaku) extract, black moji extract, black spruce extract, sisal (sisal asa) extract, saxima button candy Extract, cinnamon bud extract, Chinese pear extract (wei Sensen) extract, Oshima cherry extract, Oya cherry extract, bean cherry extract, Takane cherry extract, Kohigan extract, Sato cherry extract, Zion extract蓼) Extract, Tamshiba (hot pepper) extract, Daimonji Sou extract, Primrose extract, Toshishi extract, Legume extract, Prunus extract, Buttercup extract, Yarrow extract, Duck extract, Dill extract, Honey Bee Extract, Hamabishi Extract, Hitotsuba (Sardinum) Extract, Himegama (Incense) Extract, Peacock Extract, Floral Blanca Extract, Hamura Extract, Scallop Extract, Convolvulacea Extract, Sandalwood Extract, Mannentake Extract (Mausoleum herb extract), Chinese willow extract, Japanese red willow extract, Japanese willow extract, Japanese black willow extract, Kinu willow extract, Korean willow extract, Unryu willow extract, Japanese willow extract, Japanese willow extract, Japanese willow extract, Japanese black willow extract, Japanese black willow extract , Bayberry extract, agave extract, aonogave extract, fuchlin agave extract, mitsumata extract, aonori extract, usba aonori extract, Sueaonori Extract, Hiiraonori Extract, Bow Aonori Extract, Hosoeda Aonori Extract, Comb Extract, Macombu Extract, Resilicon Extract, Hosome Kombu Extract, Mitsuishi Kombu Extract, Wakame Extract, Hirome Extract, Aowakame Extract, Hijiki Extract, Hibamata Extract, Hibiwa Extract Umiuchiwa Extract, Kirebanoumiuchiwa Extract, Akabaumi Uchiwa Extract, Konami Uchiwa Extract,
Okinawa extract, Usuki cherry extract, Etsumi Uchiwa extract, Spikelet rhinoceros extract, Amakisakirinsai extract, Giraffe rhinoceros extract, Juniper giraffe rhinoceros extract, Tsunomata extract, Ibusunomata extract, Marubatsu no Mata extract, Hirakototoji extract, Sugi nori extract, Shikinori extract Yakuzusa extract, Uraboshiyahaz extract, Umichichiwa extract, Ishimozuku extract, Misjikonbu extract, Atsubamisujikonbu extract, Isomoku extract, Nagashimamok extract, Shimomoku extract, Nejimoku extract, Narasamo extract, Mametawala extract, Japanese chestnut extract, Yatsuma Tamamo extract Moku Extract, Fusuji Moku Extract, Haha Moku Extract, Yoremoku Extract, Sawtooth Moku Extract, Oobano Bare extract, centipede extract, nutracusa extract, cronula extract, barley podilla extract, pine tree extract, giant scorpion extract, barnyard extract, fushitsu nagi extract, himefutsu nagi extract, hirohafu tsutsunagi extract, kurosozo extract, kanezozo zozo extract , Hakasaki mushroom extract, Thira extract, Camote de Azafuran extract, Hamica extract, Poleo verde extract, Nabnegro extract, Datura extract, Pine tree extract, Vinankazura extract and the like.

Melanin production promoter A melanin production promoter can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of the melanin production accelerator include salicylic acid or a salt thereof and derivatives thereof (salicylic acid glucoside, salicylic acid fatty acid ester, salicylic acid alcohol ether, salicylic acid amides, etc.), salicyl alcohol or a salt thereof and derivatives thereof, apigenin, and amentoflavone. , Salamander extract, Udo extract, Shishido extract, Nirinso extract, Oak extract, Beef Taxi extract, Cuckoo thistle extract, Gypsophila extract, Gymnema sylvestre extract, Carrion extract, Ginkgo biloba extract, Konronka extract, Sabinryo extract, Jasmine (pine licorice) extract, hollyhock extract, scallop extract, Arabidopsis extract, lily of the valley extract, sow extract, deco extract, eucommia extract, nagii Da (Butcher Bloom) Extract, Teppouri Extract, Tokiwa Mansaku Extract, Nankin Gouze Extract, Elderberry Extract, Nadesico Extract, Mite Willow Extract, Sardine Willow Extract, Morohaya Extract Zakifujime extract, Ryokakou extract, Ajigusa extract, shellfish extract (cockle extract, green mussel extract, oyster extract, European oyster extract, scallop extract, clam extract, clam extract, bakagai extract, ishi mussel extract, red mussel extract, abalone extract, Sazae extract, bi-extract, etc.).

Humectant A humectant can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of moisturizers include gum arabic, benzoin rubber, danmar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum, carob gum, quince seed, agar or its derivatives, casein, glucose, galactose, mannose, xylose, fructose, maltose, iso Maltose, cellobiose, gentiobiose, trehalose, cordierbiose, laminaribiose, nigerose, sambubiose, neohesperidose, apiose, hammamellose, streptose, hydroxystreptose, dihydrostreptose, 2-methylerythrose or derivatives thereof, 2-methylerythrono Lactone, micalose, cladinose, accessose, alkanose, olivomai course, chromose, ebamise, vinerose , Sugars such as nogarose, bilenose, nobiose, moenuronic acid, galosamine, cybirosamine, N-acylcansosamine, vancosamine, evanitrose, rubranitrose, tetronitrose, pyralose, α-octose, trioxacalcinose, aldgarose, blastminosin 1,3-butylene glycol, glycerin, propylene glycol, polyethylene glycol, dipropylene glycol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,6-hexanediol, mannitol and Sorbitol, ethanediol, diethylene glycol, triethylene glycol, 2-amino-2-methyl-1,3-propanediol, 1,2-propanediol, 1,3-propanediol, polypropylene glycol, 1,2-butyl Diol, 1,3-butanediol, 1,4-butanediol, isopentanediol, pentylene glycol, hexylene glycol, 1,3-pentanediol, 1,4-pentanediol, 1,2,3-pentanetriol, 2,3,4-pentanetriol, 1,3,4-pentanetriol, 1,3,5-pentanetriol, 1,3-hexanediol, 1,4-hexanediol, 1,5-hexanediol, 1, 2,3-hexanetriol, 1,3,4-hexanetriol, 1,3,5-hexanetriol, 1,4,6-hexanetriol, erythritol, pentaerythritol, dipentaerythritol, threitol, arabitol, xylitol, Ribitol, galactitol, lactitol, maltitol, inositol, panthenol, laminitol, valienamine, validamine, validatitol, trehalose Is a derivative thereof, D-mannosamine and its derivative, isomaltoligosaccharide (panose), primeverose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, alkylene (C2-C4) oxide such as ethylene oxide Is added hydroxyalkyl (C2-C4) chitin or chitosan, low molecular chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or Its salt, β-1,3-glucan, β-1,4-glucan, β-1,6-glucan, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose, carboxyethylcellulose, sodium carboxyethylcellulose, hydroxy Polyalkylene oxides such as chill cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, hydroxypropyl methylcellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyethylene oxide and polypropylene oxide or cross-linking polymerization thereof. Water-soluble polymers such as carboxyvinyl polymer, polyethyleneimine, dermatan sulfate, keratan sulfate, glycerin fatty acid pyrrolidone carboxylic acid ester, glycerin fatty acid acetyl amino acid ester, pyrrolidone carboxylic acid or salt thereof, polyaspartic acid or salt thereof , Polyglutamic acid or its salt, polylysine or its salt, sodium lactate, hydantoin and its derivatives Np-vinylbenzyl-D-cellobionamide, Np-vinylbenzyl-D-lactone amide, Np-vinylbenzyl-D-maltonamide, Np-vinylbenzyl-D-gluconamide, glucosyloxyethyl methacrylate, galactosyloxy Propyl acrylate, mannosyloxyethyl methacrylate, glutamyl lysine, glutaurine, 1,2,4-butanetriol, caran-3,4-diol, azoxaponin (3-o- [β-D-glucopyranosyl-β-D-glucurono Pyranosyl] -sophoradiol, 3-o- [β-D-glucopyranosyl-3-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D- Glucuronopyranosyl] -azuxapogenol, 3-o- [β-D-glucopyranosyl] -28-o- [β-D-glucopyranosyl-β-D-glucopyranosyl] -dipsogenic acid, 3-o- [ α-L-rhamnopyranosyl-β-D-glucopyra Sil-β-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -29-o- [β-D- Glucopyranosyl-β-D-glucopyranosyl] -azuxapogenol , Maruba morning glory extract, morning glory extract, Athira (shokuyo kanna) extract, oilseed rape extract, amachazul extract, amana extract, Ayuyu extract, Hagateto extract, Hyugaito extract, Senninkoku extract, Sugimorige Ito extract, Hosoa Otome extract, Aogateto extract, Haribiyu extract, Aozulan extract, Amaranthus hippocondri Cus extract, Aristolomeria (Yurizuisen) extract, Arcana (alcanna) extract, Argarobo (cabbe) extract, Aloe vera extract, rush (1) , Dog mint extract, sardine tobacco (Iwabuchi) extract, iwahiba extract, sardine pine (roll mushroom) extract, wheat (chibusanoki) extract, duckweed (float) extract, euglena thrips extract, euglena extract, unyadegato (uncaria) extract, enokitake (榎 茸) extract, eringi extract, pre-lotus eringi extract, ogatahouken extract, oguruma (civil engineering incense) extract, euglena (cereal essence) extract, oka extract, okazeli (serpentine) extract, okra extract, onidokoro extract, Tokoroe Kiss, Nagadokoro (Hikai) extract, Ononis extract, Yuuko extract, Oyster extract, Ginseng extract, Gaku hydrangea extract, Cascara sagrada extract, Gypsophila extract, Panax ginseng extract, Kaniwa extract, Carnation extract, Gerbera extract, Camcam (camo duck) ) Extract, Color extract, Oat extract, Karin (Kiso) extract, Kawara Psycho (compulsed rape, tranquilized white grass) extract, Kawajisha extract, Kawaranadeshiko (stone bamboo) extract, Ezokawaranadeko (Soba, buckwheat) extract, Kantarasaasa extract, Kikutaniku extract, quinoa extract, cabbage extract, kiwi extract, cucumber extract, gyory (Nishikawa willow, teyanagi) extract, Kirangsou (golden grass weed) extract, guayule extract, Kusagisuzuki (Tenmon winter) extract, kudzu ) Extract, ginseng (yellow flower bud) extract, cupuas extract, gumbai tuna (Sekimei, Sekimeishi) extract, Kemponashi (Kigushi) extract, gekkavidin (Beautiful under the moon) extract, Kouren (Huo Ren) extract, coconut extract, cosmos extract, co Button leopard extract, rice oil extract, konjac extract, saffron (banban flower, west red flower) extract, sapodilla extract, sangre degrad (croton) extract, sanchinin ginseng (37 ginseng) extract, shea (carite) extract, cyanoki extract, shiitake mushroom extract Shiitake extract, shimeji mushroom extract, hin-shimeji mushroom extract, shaka shimeji mushroom extract, hatake shimeji mushroom extract, oshiroi shimeji mushroom extract, beech shimeji mushroom extract, honji mushi extract, shirotamogitake extract, shimokren extract , Ryukyu Kasamisou Extract, Ryukyu Hydrangea (Tsunayama) Extract, White Rooster Butterfly Extract, White Clover (Chicken Bones) Extract, Ginkgo biloba (Mizuka, Ryoka Flower, Shencho Flower) Extract, Watermelon (Sairan) Extract, Suzu-Psycho (Xulongan) Extract, Surihiyu (Horse Soap, Horse Teeth) Extract, Sekkoku Extract, Sakura Sekkoku Extract, Koki Sekkoku Extract, Obanase Sekkok Extract, Okinawa Sekkok Extract, Hon Sekkokoku Extract, Shika Sekkokoku Extract, Kiba Nano Sekkok Extract, Cedron (Boushuboku) extract, mallow extract, celery extract, senshinren (baffled ream) extract, Japanese radish (radish) extract, Takasaburo (Boku lotus) extract, Tachidokoro (hikai) extract, dahlia (tenjiku button) extract, tarwi extract, sen Kinshi extract, soju Tulip extract, Chanca Piedra extract, Tulip extract, Chorogi extract, Tsukuritake mushroom extract, camellia extract, camellia extract, Tounabena extract, corn extract, corn hair , Toxa (wood bandits) extract, ash (crustacean) extract, turkey falcon extract, peanut extract, vertical blade (sword bean) extract, jujube (large cocoon) extract, navena (continuous) extract, nameco extract, namban ramie (cannabis) extract , Niois violet extract, nutmeg extract, Nemum extract, Nebu extract, Nebi extract, Nemkinoki extract, Digokubana extract Extracts Extract, bell pepper extract, Japanese apricot extract, Japanese pine bamboo (Kawariharatake, Hiromatsutake) extract, eucheuma (Coleoptera) extract, Brazilian licorice extract, hazelnut extract, loofah extract, red-breasted extract, Ikusa (jingten) extract, Bakigi extract, Chrysanthemum extract, Nendodon extract, Hahagigi Kokia (geum coconut) extract, spinach (Akansen, Acute pupa, Periosteum) extract, Diptera edulis extract, Hosobakirinso (Keiten zosan) extract, Jojoba Kiss, Borage extract, Bordeaux extract, Hononiku (meat juju, Taigei) extract, Honsekkok (iron skin stone, Sparrow mountain stone) extract, Maca extract, Macadamia nut extract, Margaret (Mokushungiku) extract, Tamanozen Hallen Extract, kyukonkinrenka extract, matatabi (wooden cocoon) extract, pine coconut extract, matsuhodo (cocoon) extract, matico (cordon sillo) extract, quince extract, malein (biloudomozuika) extract, manzanya (andesukamitsuru) extract, mizusobako extract , Japanese morning glory extract, green mint extract, wheat straw extract, munya extract, purple extract, purple purple extract, purple jelly extract, moge extract, mochinoki extract, Yag Masowa extract, Yacon extract, Palm extract, Yabu tobacco (Tsurugai, Tenmeisei) extract, Maronnier extract, Mokka extract, Lily extract, Raigan (Raimaru) extract, Lime extract, Rye extract, Rakkyou extract, Shallot (palm white) extract, Apple extract , Gentian extract, litchi (piper, toothpick) extract, lotus extract, yokuinin extract, minisasaniki extract, chlorella vulgaris extract, chlorella pyrenoid extract, chlorella ellipsoidia extract, macrocystis pirifera extract, euquiri extract , Tosakanori extract, Cyprinus extract, Amakusa Nori extract, Aoimidro extract, Kawanoori extract, Marimo extract, Mochikihitoe extract, Ezoyahaz extract, Habanori extract, Atlantic havanori extract, Cottontail extract, A Extract, squirrel extract, trolley extract, antokume extract, pickled alley extract, black squirrel extract, cat corn extract, Ainu turtle extract, chigaiso extract, squirrel extract, yabanemoku extract, trumpet extract, uganomoku extract, joromoku extract, hyamok extract, tamanashi moku extract, Honda Walla Extract, Sugi Moku Extract, Bovine Kenori Extract, Susabi Nori Extract, Akebono Mozuku Extract, Sea Elephant Swine Extract, Fusanori Extract, Hoso Banamino Hana Extract, Hanaf nori Extract, Itohnori Extract, Kaginori Extract, Mirin Extract, Hoso Bamirin Extract, Chrysanthemum Extract, Ezonameshi Extract Ibaranori Extract, Kaigai Baranori Extract, Saidaibara Extract, Tachiibara Extract, Ogonori Extract, Tsurushiramoeki , Bee Zhou Gelidium nilotica extract, Okitsunori extract, Aqaba ginkgo Saw extract, natto culture metabolites, natto extract, sponge gourd water, birch (birch) or Akamatsu sap, and the like.

Cell activating agent / metabolic activator A cell activating agent / metabolic activator can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of cell activators and metabolic activators include vitamin A group: retinol or its salts and derivatives thereof (retinyl unsaturated fatty acid esters such as retinyl linoleate, retinyl linolenate, retinyl oleate, retinyl arachidate, etc.) ), Retinal or a salt thereof and derivatives thereof, dehydroretinal or a salt thereof and derivatives thereof, retinoic acid or a salt thereof and derivatives thereof, retinoic acid analog (4-[[[8- (3,5-dimethylphenyl ) -2-Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3-methylphenyl) -2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[[8- (4-methylphenyl) ) -2-Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3,4- Dimethylphenyl) -2-naphthaleni ] Carbonyl] amino] benzoic acid, 4-[[[8- (2,4-dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-isopropylphenyl) -2 -Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-ethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-fluorophenyl) -2 -Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methoxyphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(8-benzyl-2-naphthalenyl) carbonyl] Amino] benzoic acid, 4-[(E) -2- (8-phenyl-2-naphthalenyl) propenyl] benzoic acid), retinoic acid derivative (4-hydroxyphenylretinamide), retinoid analogue (4-[[( 5,6-dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) Amino] Kerr Bonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5, 5-dimethyl-8-ethyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) -carbonyl] amino] benzoic acid, 4- (E)-[2- (5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) -1-propenyl] benzoic acid, 4-[[((5,6-dihydro-5 , 5-Dimethyl-8-phenyl-2-naphthalenyl) oxy] carbonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] amino] Benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] oxy] benzoic acid, 4-[[5,6-dihydro-5,5- Dimethyl-8- (2-fluorophenyl) -naphthalenyl] carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5,6-trimethyl) ] -8-phenyl-2- (naphthalenyl) carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5,7-trimethyl-8-phenyl-2-naphthalenyl) carbonyl] benzoic acid, 4-[[((E)-(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] vinyl] benzoic acid, 4-[[[((5,6-dihydro-5,5 -Dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] sulfamyl] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] sulfamyl] carbonyl] benzoic acid Acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl -8-phenyl) -2-naphthalenyl] thiocarbonyl] amino] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] methyl] benzoic acid Acid, 4-[[[((5,6-Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] oxy] benzoic acid Acid 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthenyl] oxy] methyl] benzoic acid, 4-[[[((5,6-dihydro-5, 5-dimethyl-8- (2,4-dimethylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8- (4- Methylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4- [ [[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] sulfamyl] methyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8- Phenyl) -2-naphthalenyl] methyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] amino] thiocarbonyl] benzoic acid, 4 -[[[((5,6-Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] sulfamyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl - 8-phenyl-2-naphthalenyl] amino] methyl] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-hydroxy Benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-nitrobenzoic acid, 4-[[[((5,6 -Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-fluorobenzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-Naphthalenyl] carbonyl] amino] -2-methoxybenzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8- (2-naphthalene)]-2-naphthalenyl] carbonyl] amino ] Benzoic acid, 4-[[(5,6-dihydro-8-phenyl-2-naphthalenyl) carbonyl] aminobenzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl- 2-Naphthalenyl) carbonyl] amino] -3-fluorobenzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl) Enyl-2-naphthalenyl) carbonyl] amino] -3-methylbenzoic acid, 4-[[((5,8,10,10a-tetrahydro-10,10-dimethyl-9-phenyl-2-anthracenyl) carbonyl] amino] Benzoic acid, 4-[[(1,1-dimethyl-3-phenyl-1H1-inden-5-yl) amino] carbonyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-indene -5-yl-oxymethyl) benzoic acid, 4- [2- (1,1-dimethyl-3-phenyl-1H-inden-5-yl) vinyl] benzoic acid, 4-[(1,1-dimethyl- 3-phenyl-1H-indene-5-carbonyl) amino] benzoic acid), carotene or salts thereof and derivatives thereof (α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthine, lutein, zeaxanthin, isoseaxanthin, rhodoxanthine , Carotenoids such as capsanthin and crocetin), lycopene or its salts and derivatives thereof, vitamin B group: thiami Or salts thereof and derivatives thereof (thiamine hydrochloride, thiamine disulfide, bisbenchamine, bisbutiamine, thiamine monophosphate disulfide, benfotiamine, chicotiamine, octothiamine, discetiamine, fursultiamine, prosultiamine, astaxanthin Thiamine phosphate diester, etc.), thiamine sulfate, riboflavin or its salts and derivatives thereof (flavin adenine dinucleotide, flavin mononucleotide, riboflavin phosphate diester, 1-β-D-ribofuranosylnicotinamide pyrophosphate diester, 1 -β-D-ribofuranosylnicotinic acid, etc.), pyridoxine or its salts and derivatives thereof (pyridoxine 3,4-dipalmitate, pyridoxine 3,4-dicaprylate, pyridoxine sulfate diester, etc.), pyridoxer Or salts thereof and derivatives thereof, pyridoxamine or salts thereof and derivatives thereof, cyanocobalamin or salts thereof and derivatives thereof, cobalamines (such as methylcobalamin, adenosylcobalamin, hydroxocobalamin, aquacobalamin), folic acid or salts thereof, and Derivatives thereof, nicotinic acid or salts thereof and derivatives thereof, pantothenic acid or salts thereof and derivatives thereof, biotin or salts thereof and derivatives thereof, choline or salts thereof and derivatives thereof, inositol or salts thereof and derivatives thereof , Vitamin C group: ascorbic acid or a salt thereof and derivatives thereof, vitamin D group: ergocalciferol or a salt thereof and derivatives thereof, cholecalciferol and a salt thereof and derivatives thereof (1α-hydroxy-22-[(1 -Hide Xyl-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1R, 4R] -1α-hydroxy-22-[(1- Hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1R, 4S] -1α-hydroxy-22-[(1- Hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1S, 4R] -1α-hydroxy-22-[(1- Hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1S, 4S] -1α-hydroxy-22-[(1- Hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, etc.), dihydrotaxosterol or a salt thereof and derivatives thereof, vitamin E group : Tocopherol or a salt thereof and derivatives thereof, Tocotrie Nord or a salt thereof and derivatives thereof, ubiquinone or a salt thereof and derivatives thereof, vitamin K group: phytonadione or a salt thereof and derivatives thereof, menaquinone or a salt thereof and derivatives thereof, menadione or a salt thereof and derivatives thereof, menadiol Or salts thereof and derivatives thereof, vitamin F group: linoleic acid or salts thereof and derivatives thereof, linolenic acid or salts thereof and derivatives thereof, arachidonic acid or salts thereof and derivatives thereof, carnitine or salts thereof and Derivatives, ferulic acid or a salt thereof and derivatives thereof, γ-oryzanol or a salt thereof and derivatives thereof, orotic acid or a salt thereof and derivatives thereof, vitamin P group: rutin or a salt thereof and derivatives thereof, eriocitrin or a derivative thereof Salt and it Derivatives, hesperidin or salts thereof and derivatives thereof, vitamin L group: anthranilic acid or salts thereof and derivatives thereof, adenylthiomethylpentose or salts thereof and derivatives thereof, vitamin U group: methylmethionine sulfonium chloride or derivatives thereof , Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, Histidine or its derivatives (N-octyloxycarbonyl-β-alanyl-L-histidine, N-dodecyloxycarbonyl-β-alanyl-L-histidine, N- (12-amino-1-oxo Dodecyl) -L-histidine, N-2-ethylhexyloxycarbonyl-β-alanyl-L-histidine hydrochloride, N-hexadecyloxycarbonyl-β-alanyl-L-histidine, N-octylaminocarbonyl-β-alanyl- L-histidine, N-dodecylaminocarbonyl-β-alanyl-L-histidine, N-dodecylsulfonyl-β-alanyl-L-histidine, N-dodecylamino-oxalyl-β-alanyl-L-histidine, etc.) Amino acids such as sulfates, phosphates, nitrates, citrates or amino acid derivatives such as pyrrolidone carboxylic acid, α-hydroxy acids such as glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, succinic acid, 2-hydroxycarboxylic acids (methyl lactic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid, 2-hydroxyheptanoic acid, 2-hydroxy Tannic acid, 2-hydroxynonanoic acid, 2-hydroxydecanoic acid, 2-hydroxyundecanoic acid, α-hydroxylauric acid, α-hydroxymyristic acid, α-hydroxypalmitic acid, α-hydroxystearic acid, α-hydroxyarachidonic acid , Cerebronic acid, α-hydroxynervonic acid, mandelic acid, benzylic acid, phenyllactic acid, atrolactic acid, 2- (4'-hydroxyphenyl) -2-hydroxyethanoic acid, 2- (4'-chlorophenyl) -2-hydroxy Ethanoic acid, 2- (3′-hydroxy-4′-methoxyphenyl) -2-hydroxyethanoic acid, 2- (4′-hydroxy-3′-methoxyphenyl) -2-hydroxyethanoic acid, 3- (2 ′ -Hydroxyphenyl) -2-hydroxypropanoic acid, 3- (4'-hydroxyphenyl) -2-hydroxypropanoic acid, 2- (3 ', 4'-dihydroxyphenyl) -2-hydroxyethanoic acid, glyceric acid, erythrone Acid, ribo Acid, arabinonic acid, xylonic acid, lyxonic acid, aronic acid, altronic acid, gluconic acid, mannonic acid, gulonic acid, idonic acid, galactonic acid, taronic acid, glucoheptonic acid, galactoheptonic acid, tartronic acid, mucinic acid, etc.), poly Hydroxycarboxylic acid or hydroxypolycarboxylic acid (gluconolactone, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, saccharide lactone, pantoyl lactone, glucoheptonolactone, mannonolactone, galactoheptono Lactones), 2-keto acids (glyoxylic acid, methyl 2-ketoethanoate, benzoylformic acid, methyl benzoylformate, ethyl benzoylformate, phenylpyruvic acid, methyl phenylpyruvate, ethyl phenylpyruvate, 2-ketobutanoic acid, 2- (Ketopentanoic acid, 2-ketohexanoic acid, 2-ketoheptanoic acid, 2-ketooctanoic acid, 2-ketododecanoic acid, methyl 2-ketooctanoate, etc.), quinic acid, isocitric acid, tropic acid, tretocanic acid, 3-chlorolactic acid, cerebronic acid , Citramalic acid, agaricinic acid, aleuricinic acid, pantoic acid, lactobionic acid, hexulosonic acid, photosensitizer 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, pentadecanoic acid glyceride, linolenic acid or derivatives thereof, eicosapentaenoic acid or derivatives thereof Docosahexaenoic acid or a derivative thereof, estradiol, etenyl estradiol, antialol or a glycoside thereof, rioniresinol or a glycoside thereof, rhododendrol or a glycoside thereof, platifironol or a glycoside thereof, γ-amino- β-hydroxy Acid esters (γ-amino-β-hydroxybutyric acid methyl ester, γ-amino-β-hydroxybutyric acid ethyl ester, γ-amino-β-hydroxybutyric acid propyl ester, γ-amino-β-hydroxybutyric acid butyl ester, γ- Amino-β-hydroxybutyric acid ethylhexyl ester, γ-amino-β-hydroxybutyric acid hexadecyl ester, γ-amino-β-hydroxybutyric acid lauryl ester, γ-amino-β-hydroxybutyric acid stearyl ester, γ-amino-β-hydroxy Butyric acid oleyl ester, γ-amino-β-hydroxybutyric acid benzyl ester, γ-amino-β-hydroxybutyric acid phenyl ester, γ-amino-β-hydroxybutyric acid ethyl glycol ester, γ-amino-β-hydroxybutyric acid sorbitol ester, γ -Amino-β-hydroxybutyric acid polyoxyethylene glycol ester, γ-amino-β-hydro Glycerin ester of butyric acid), lactone compounds (D-glucurono-6,3-lactone, α-D-glucoheptonic-γ-lactone, δ-glucuronolactone, α, β-glucooctonic-γ-lactone, L-glonic-γ-lactone, γ-D-galactonolactone, D-saccharide-1,4-lactone, D-saccharide-3,6-lactone, D-ribonic-γ-lactone, α-butyrolactone, γ- Butyrolactone, α-octanoic lactone, γ-octanoic lactone, nonanoic lactone, γ-valerolactone, D-manninoic-δ-lactone, D-xylocic-δ-lactone, D-arabinoic-δ-lactone, stearoyl -δ-gluconolactone, DL-pantolactone, palmitoyl-DL-pantolactone, etc.), 3-hydroxy-3,4-dicarboxy-1,4-butanolide or derivatives thereof, 6-benzylaminopurine or derivatives thereof Body, 1,4-diazadicyclooctane, 2,5-dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran, rutin, tectrigenin 7-xylosylglucoside, captopril, Alacepril, lisinopril, enalapril, delapril, benazepril, cilazapril, imidapril, quinapril, trandelapril, perindopril, temocapril, losartan, endothelin, galactomannan saccharide polymer, mucin, trimethylglycine, proteoglycan, lactic acid bacteria extract, lactic acid bacteria extract Milk extract, bifidobacteria extract, bifidobacteria culture broth extract, bifidobacteria fermented milk extract, placenta extract, ganoderma extract, spleen extract, thymus extract, yeast extract, yeast culture broth extract, yeast ferment extract, thread Fungus extract, filamentous fungus culture fluid extract, basidiomycete extract, basidiomycete culture fluid extract, bacterial cell disruption extract, bacterial culture extract, cultured human dermal cell disruption extract, red pheasant (ground yellow) extract, fennel (mushroom) extract , Ezokogi (Kayagoka) extract, Barley (barley) extract, Okuri Higotai (Zhengzhou Leakage) extract, Kagome Hypericum extract, Hypericum perforatum extract, Dutch jellied extract, Dutch honey beet extract, Silkworm extract, Roman chamomile extract, Garcinia extract, Kawarani carrot (blue persimmon) extract, oyster extract, quilla extract, quince extract, ginkgo biloba extract, calendula extract, sakane ran extract (Ezo-sakane ran extract), Saba-Gin ran extract, Sawaguru mash extract, Shimotsuke extract, Shajin (San gins) extract , Plum Kiss, Japanese walnut extract, Japanese horsetail extract, Pineapple extract, Chinese cabbage extract, Japanese cypress extract, beech extract, Japanese physalis extract (Torone) extract, Maitake extract (maiko) extract, Misohagi extract, Makuge (Kiso) Extract, Mukuroji (life extension skin) extract, bean sprout extract, Eucalyptus extract, Yukinoshita (tiger ear grass) extract, Suabisimus extract, Lettuce (Chisha) extract, Aloe extract, Ogon extract, Tonka bean extract, Gentianana extract, Burdock Extract, Shikon Extract, Carrot Extract, Camelis Extract, Hop Extract, Yokuinin Extract, Odorikosou Extract, Senburi Extract, Toki Extract, Ginseng Extract, Achacha Extract, Hypericum Extract, Cucumber Extract, Dipper Extract, Rosemary Extract, Parsley Kiss, Sandagusa extract, Fukurimamiji extract, Ragby comb extract, Oyster comb extract, Onikonbu extract, Gohei comb extract, Nagacomb extract, Pea extract, Prunus extract, Rattle extract, Rattle extract, Beni Mozuku extract , Hosobenimozuku extract, Kagekinori extract, Ezotosaka extract, Silamo extract, birch extract and the like.

Antioxidant An antioxidant can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of antioxidants include ascorbic acid or a salt thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl hydroxyprophosphate, 5-o-α -D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid Sulfate aluminum Nium salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyranosyl -L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl-L -Ascorbic acid, 6-o-alkylascorbic acid potassium phosphate, 6-o-alkylascorbic acid phosphate calcium Um salt, 6-o-alkyl ascorbic acid phosphate barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o-alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl ascorbine Acid phosphate ester diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine Salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate Cholesterol ester, L-ascorbyl palmitate, L-isopalmitate Scorbyl, L-ascorbyl dipalmitate, L-ascorbyl diisopalmitate, L-ascorbyl stearate, L-ascorbyl isostearate, L-ascorbyl distearate, L-ascorbyl diisostearate, L-ascorbyl myristate, isomyristic acid L-ascorbyl, dimyristic acid L-ascorbyl, diisomyristic acid L-ascorbyl, 2-ethylhexanoic acid L-ascorbyl, di-2-ethylhexanoic acid L-ascorbyl, oleic acid L-ascorbic acid, 2-o-α -D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D- Glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitin Ester, L-Ascorbic acid tetralauric acid ester, L-Ascorbic acid tetra-2-ethylhexanoic acid ester, L-Ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol Ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbine Acid triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl] -4 ' -Acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphate diester, ascorbic acid boar Binding derivatives, ascorbic acid phosphoramide derivatives, ascorbic acid arbutin conjugates, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivatives, ascorbic acid sialic acid derivatives, etc.), stearates, tocopherols or their salts and derivatives thereof (α-tocopherol) , Β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate, tocopherol succinate , Tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl Glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-toco Ferryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ- Tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ -Tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- (sulfoethylamino) -3- (α-tocopheryl-6- (Iloxy) propan-2-ol, 1- (carbo Cypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-Tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxy Propyl] aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ- Tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate), dihydropyridine derivatives (methyl-3- Enyl-2-propenyl 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) pyridine-3,5-dicarboxylate and its salts), benzochroman derivatives, nordihydrogua ceretenoic acid, butyl Hydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, coenzyme Qn (n = 7-10), pyrroloquinoline quinone, propyl gallate, sesamol, sesamolin, gossypol, maritimane, sulfretin, xanthene -2,7-diols, caffeoylquinic acids, propolis, carotenoids (α-carotene, β-carotene, γ-carotene, lycopene, lutein, violaxanthin, spiroloxanthine, spheroidene, astaxanthin, etc.), fluorotannin, Akebi extract, Achacha extract, Oolong Chaeki , Dutch bay extract, kanran extract, kumquat extract, goby extract, ginseng extract (old lady's grass) extract, sesame extract, sesame cultured cell extract, sesame extract, ginseng extract, rice bran extract, pomegranate extract, salamander extract, pear Extract, Daio extract, Tomato extract, Nanten extract, Noami (Otsuchi) extract, Neubara extract, Paprika extract, Pistachio extract, Biwa extract, Betel nut extract Buffalo extract, Bokeh extract, Hosobaoguruma extract, Mao (mao) extract, Mimosa extract, Mebouki extract, Himekuma willow extract, Yanagita extract, Watafujitsugi extract , Akaba Miuchiwa extract, Examples include Hypericum extract, Clam extract, Clove extract, Melissa extract, Enmezo extract, Birch extract, Salvia extract, Rosemary extract, Nanten extract, Ginkgo biloba extract, Green tea extract, Clove extract and the like.

Active oxygen scavenger / radical scavenger An active oxygen scavenger / radical scavenger can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of active oxygen scavengers and radical scavengers include superoxide dismutase, catalase, glutathione peroxidase, bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or derivatives thereof, gallic acid or salts thereof, and derivatives thereof, curcumin Or salts thereof and derivatives thereof, transferrin, ceruloplasmin, coenzyme Qn (n = 7 to 10), uric acid, bilirubin, metallothionein, stilbengaloyl glycoside (3,5,4′-trihydroxystilbene 4′-o -β-D- (6 "galloyl) glucopyranoside, 3,5,4'-trihydroxystilbene 4'-o-β-D- (2" galloyl) glucopyranoside, etc.), chlorogenic acid phospholipid ester, chlorogenic acid sphingosine ester And derivatives thereof, chlorogenic acid glycolipid ester, chlorogenic acid sugar Steal, chlorogenic acid sterol ester, thiazole derivative or salt thereof (2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxyphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- [3-carboxy-4-hydroxy-5- (2-methyl-2-propenyl) phenyl] thiazole and 2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxy- 5-Methylphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- (3-carboxy-5-methoxyphenyl) thiazole), hydroxymatylesinol, allohydroxymatylesinol, hydantoin derivatives, acetylcarnitine Or a salt thereof, geranylgeranylacetone, a hydroxamic acid derivative or a salt thereof, gingerone glycoside, a benzeneoxyacetic acid derivative ([5- [2- [1-phenyl-1- (3-pyridyl) methylideneaminooxy] ethyl]- 7,8-Dihydronaphtha N-1-yloxy] acetic acid), isorhamnetin-3-robinobioside, xanthone derivatives, proanthocyanidins (grape seed extract proanthocyanidins, apple-derived proanthocyanidins, pine-derived proanthocyanidins, purified procyanidin oligomers, procyanidin B-1, procyanidins B-2, procyanidin B-3, procyanidin C-1, etc.), Akaminoki (logwood) extract, Akamegashiwa (red bud) extract, Acamino red extract, Acacia extract, Akane (root) extract, Hydrangea (hydrangea) extract , Abemaki Extract, Fig Extract, Ginkgo (Ginkgo) Extract, Asparagus Extract, Plum (Plum Plum) Extract, Vulgaris Extract, Waxy Urushi (Bearberry) Extract, Estragon Extract, Enju (Plum Blossom, Spike Flower Rice) Extract, Oak Wrinkle , Leaves) extract, mosquito Ginseng extract, Hippopotamus extract, Birch extract, Kunugi extract (笹) extract, perilla extract, ajido extract, chili mushroom extract, catamendizo extract, peonies extract Extract, green tea extract, camellia extract, tencha (boiled tea) extract, tender eel extract, nani waibara (gold cherry tree) extract, peanut (peanut) extract, kei extract, nikkei extract, ceylon nicki extract, Yabunikei extract, Keishi extract, Lotus flower extract, Lotus extract, Chinese cabbage extract, Japanese cabbage extract, Hanasuga extract, Hanamasu extract, Rose extract , Barbasco extract, spinach extract, beech extract, American beech extract, European beech extract, European beech extract, convolvulus extract, scallop extract, button (peony) extract, mayola rum extract, melon extract, evening primrose extract, snowy willow extract , Orchid extract, rakanka extract, rooibos extract, naminohana extract, eucalyptus extract, judo eucalyptus extract, azusa extract, basil extract, mokko (wood fragrance) extract, himefuuro extract, lemongrass extract and the like.

Fat metabolism promoter A fat metabolism promoter can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of fat metabolism promoters include phthalazine derivatives (4-ethyl-1- (β-hydroxyethylamino) phthalazine, 4-N-propyl-1- (β-hydroxyethylamino) phthalazine, 4-N-butyl- 1- (β-hydroxyethylamino) phthalazine, 4-N-butyl-1- (β-hydroxypropylamino) phthalazine, etc.), xanthine derivatives (caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, diprofylline, proxy) Phyllin and oxtriphilin, etc.) Extract, Gajuttsu (boiled) extract, Chrysanthemum salmon extract, Kyoko Root) Extract, Ivy Extract, Pepper (Pepper) Extract, Cola Acminata Extract, Sagiomodaka (Sawamata) Extract, Pomelo Extract, Sansyuyu (Yamamuro) Extract, Tsuba Rafuji Extract, Ootsuki Rafuji Extract, Choreimaitake (Amber) Extract, Clover Extract , Prickly pear extract, red ginseng extract, ginseng extract (dragon gall) extract, naginata kouju extract, banana extract, puer tea (common ear tea) extract, plum extract, boufu (windproof) extract and the like.

UV protection agent / UV absorption promoter A UV protection agent / UV absorption promoter can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of UV protection agents and UV absorption accelerators include benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5- Sodium sulfonate, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), 1,2-dihydroxy-4- (2-hydroxyethyl) benzene derivatives (1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) -3- Rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (2-acetyl-4- (3,4-dihydroxycinnamoyl) -3-rhamno L) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (2-acetyl-6- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (6- (4-hydroxy-3-methoxycinna) Moyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-methoxyethyl-3, 4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-hydroxyethyl-3,4-dihydroxybenzene, 1- (2- (6- (3,4-Dihydroxycinnamoyl) -3-xylosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (3-arosyl-6- (3-hydroxy-4-methoxycinnamoyl) ) Glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (3-glucosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1 -(2- (3-Allosyl-6- (3-hydroxy-4-methoxycinnamoyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (4- (3,4-dihydroxycinna Moyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (3- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (2 -(3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene Paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, paradimethyla Amyl benzoate, octyl paradimethylaminobenzoate), methoxycinnamate derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, paramethoxycinnamate Potassium, diparamethoxycinnamate mono-2-ethylhexanoate glyceryl, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, Tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, pyridoxine derivatives, Pyridoxal derivative, pyridoxamine derivative, amethoflavone, neosacranin, 6-dehydrocarbine, triazine derivative (4,4'4 "-(1,3,5-triazine-2,4,6-triyltriimino) trisbenzoic acid tris- 2-ethylhexyl etc.), phosphatidyl chromanol derivatives (1,2-dilaurylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman 1,2-dimyristoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-dipalmitoylglycero-3- Phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-distearoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-Tetramethyl-6'-hydroxychroman, 1,2-dialachidonylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'- Tramethyl-6′-hydroxychroman, 1-myristoyl-2-palmitoylglycero-3-phospho-2′-hydroxymethyl-2 ′, 5 ′, 7 ′, 8′-tetramethyl-6′-hydroxychroman, 1- Myristoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-palmitoyl-2-myristoylglycero-3-phospho -2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-palmitoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6'-hydroxychroman, 1-stearoyl-2-myristoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetra Methyl-6′-hydroxychroman, 1-stearoyl-2-palmitoylglycero-3-phospho-2′-hydroxymethyl-2 ′, 5 ′, 7 ′, 8′-tetramethyl-6′-hydroxychroman, etc.) , L-carnosine zinc complex, umbelliferone, esculin, benzyl cinnamate, cinoxalate, oxybenzone, dioxybenzone, octabenzone, soribenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, chlorophylls, xanthophylls , Escalol, Zinc Oxide, Talc, Kaolin, Anthrac (Buckthorn) Extract, Hub Extract, Giant Plover Extract, Asamidori Shigusa Extract, Kawachigusa Extract, Kawatake Extract, Cypridosa Extract, Hassai Extract, Spirulina Extract, Iacashio Extract, Funori no Ushike Extract , Japonica extract, Hytengus extract, Oobusa extract, chinolimo extract and the like.

Astringents Astringents can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of astringents are succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannins (tannic acid, hamamelitannin Acer tannin, tetragalloyl glucose, pentagalloyl glucose, hexagalloyl glucose, heptagalloyl glucose, octagalloyl glucose, nonagaroyl glucose, decagalloyl glucose, undecagalloyl glucose, dodecagalloyl glucose, etc. Gallotannins, telimaglandin I, telimaglandin II, casarictin, peduncraggin, geraniin, isotarkevin, granatin A, granatin B, ketulinic acid, keblagic acid, casuarinin, nuphalin, procyanidin B-2, Eladitannins such as thiacinensin A and thiacinensin B), red grape extract, red bean extract, altea extract, nettle extract, cascarilla extract, kapoch extract, guarana extract, ezoba strawberry extract, Dutch strawberry extract, shrimp strawberry extract , Nawashiro Strawberry Extract, Maple Strawberry Extract, European Raspberry Extract, Kidney Aloe Extract, Hawthorn Extract, Coustella Hakka Extract, Cowberry (Etsutachibana) Extract, Cola Vera Extract, Sugarcane Extract, Sinah Honoki Extract, Honeysuckle Extract Q) Extract, larch extract, elder extract, dandelion extract, centalium extract, white dandelion extract, mud dandelion extract, vine azuki bean extract, tsurutsu Akebi extract, Teuchigurumi extract, Tormentilla extract, Novara extract, Buttercup extract, Hagoromogusa extract, Castor extract, Grape extract, Prune extract, Veronica extract, Bisnaga extract, Bilberry extract, Mansuguru extract, Mitsugashi extract, Myrrh extract, Melissa extract, Examples include witch hazel extract, bay willow extract, latania (chlamelia) extract, lemon extract, and dairy extract.

Anti-inflammatory agent, interleukin production inhibitor, histamine release inhibitor An anti-inflammatory agent, interleukin production inhibitor, histamine release inhibitor can be added to cosmetics or quasi drugs containing the agent of the present invention. . Specific examples of anti-inflammatory agents, interleukin production inhibitors and histamine release inhibitors include quinolinone derivatives, dibenzooxepin derivatives, thiotroposin, phthalimide derivatives, flurbiprofen, felbinac, bufexamac, suprofen, 1,4-diphenylpropyl Piperazine derivatives, carxin compounds, chromanol glycosides (2- (α-D-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol), ictamol, indomethacin, kaolin, diphenhydramine hydrochloride, d- Camphor, DL-camphor, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, diphenhydramine hydrochloride, clemastine fumarate, cyproheptadine hydrochloride, hydrochloric acid Lomethazine, piperazine derivatives, α-D-phenylglycoside derivatives, glycyrrhizic acid or its salts and derivatives thereof (α-glycyrrhizic acid, β-glycyrrhizic acid, α-glycyrrhizic acid methyl ester, β-glycyrrhizic acid methyl ester, α-glycyrrhizin Trisodium acid, monopotassium α-glycyrrhizinate, dipotassium α-glycyrrhizinate, monoammonium α-glycyrrhizinate, trisodium β-glycyrrhizinate, monopotassium β-glycyrrhizinate, dipotassium β-glycyrrhizinate, monoammonium β-glycyrrhizinate ), Glycyrrhetinic acid or a salt thereof, and derivatives thereof (α-glycyrrhetinic acid, β-glycyrrhetinic acid, stearyl α-glycyrrhetinate, stearyl β-glycyrrhetinate, pyridoxine α-glycyrrhetinate, Pyridoxine ruretinate, glyceryl α-glycyrrhetinate, glycerin β-glycyrrhetinate, disodium 3-succinyloxyglycyrrhetinate, etc.), mefenamic acid, phenylbutazone, ibuprofen, ketoprofen, allantoin, calcium pantothenate, pantothenyl ethyl ether, etc. Panthenol or salts thereof and derivatives thereof, ε-aminocaproic acid, diclofenac sodium, tranexamic acid or derivatives thereof (trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexane) Carboxylic acid, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-bromobenzyloxycarbonylaminomethyl Cyclohexanecarboxylic acid, trans-4-m-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexane Carboxylic acid, sodium trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylate, ammonium trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylate Trans-4-p-bromobenzyloxycarbonylaminomethyl potassium cyclohexanecarboxylate, trans-4-m-chlorobenzyloxycarbonylaminomethyl Calcium tilcyclohexanecarboxylate, trans-4-p-methoxybenzyloxycarbonylaminomethyl magnesium cyclohexanecarboxylate, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexanecarboxylic acid monoethanolamine, trans-4-t-butyloxy Carbonylaminomethylcyclohexanecarboxylic acid, trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (3, 5-Dimethoxyphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid , Sodium trans-4-t-butyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylate, trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) Calcium cyclohexanecarboxylate, trans-4- (3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) magnesium cyclohexanecarboxylate, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid monoethanolamine, trans -4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarbo Acid, sodium trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylate, potassium trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4- (pyridine-4'-methyl Oxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylate potassium, trans -4- (pyridine-4'-methyloxycarbonylaminomethyl) cyclohexanecarboxylate sodium, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylate potassium, trans-4- (2- Trimethylsilyl Ethoxycarbonylaminomethyl) cyclohexanecarboxylate, etc.), sulfatide, astaxanthin fatty acid diester (astaxanthin dilaurate, astaxanthin dimyristate, astaxanthin dipentadecanoate, astaxanthin dipalmitate, astaxanthin dipalmitoleate, Astaxanthin diheptadecanoic acid ester, astaxanthin dielaidic acid ester, astaxanthin diricinoleic acid ester, astaxanthin petroselinic acid ester, astaxanthin vaccenic acid ester, astaxanthin eleostearic acid ester, astaxanthin punicic acid ester, astaxanthin ricinic acid ester, astaxanthin paris Naphosphate , Astaxanthin gadoric acid ester, astaxanthin 5-eicosenoic acid ester, astaxanthin 5-docosenoic acid ester, astaxanthin cetolic acid ester, astaxanthin erucic acid ester, astaxanthin 5,13-docosadienoic acid ester, astaxanthin ceracholic acid ester, astaxanthin decenoic acid Ester, astaxanthin steric acid ester, astaxanthin dodecenoic acid ester, astaxanthin dioleic acid ester, astaxanthin distearic acid ester, astaxanthin dieicosapentaenoic acid ester, astaxanthin didocosahexaenoic acid ester, astaxanthin dilinolenic acid ester, astaxanthin dilinolenic acid ester, astaxanthin diester Arachidonic acid ester ), Astaxanthin diglycerophosphate (astaxanthin diglycerophosphate, astaxanthin lyserophosphate palmitate, astaxanthin lysephrophosphatidylcholine palmitate, astaxanthin lysephrophosphatidylcholine DHA, astaxanthin lysephrophosphatidylinositol palmitate, astaxanthin Fattidylinositol DHA, astaxanthing lyserophosphatidylinositol linoleic acid, astaxanthing lyserophosphatidylcholine linoleic acid, etc.), steviol glycosides, benzimidazole derivatives (1- (2-ethoxyethyl) -2- [1- (2 -(4- (1- (4,4-Dimethyl-2-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4 -(2- (4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoic acid, ethyl 2- [4- (2- ( 4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanate, 1- (2-ethoxyethyl) -2- [1- ( 2- (4- (1,1-dimethyl-2-hydroxyethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 1- (2-hydroxyethyl) -2- [1- (2- (4- (1- (4,4-Dimethyl-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- ( 4- (1- (2-hydroxyethyl) benzoimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoic acid), alanine derivatives or salts thereof (N- [3-isopentyl- 4-Methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H- Azoline-5-carbonyl] -L-alanine, N- [3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl] -2- Methylalanine, N- [3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl] -N-methyl-L-alanine, etc.) Thiazoline derivative or its salt (3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid, 4-isobutyl-3-methyl-2- [4- (3-trifluoromethylbenzamide) benzoylimino] -3H-thiazoline-5-carboxylic acid, etc.), chlorpheniramine maleate, diphenhydramine hydrochloride, diphenylpyramine hydrochloride, carbinoxamine maleate, hydrocortisone butyrate, sulfated acidic mucos Polysaccharide or salt thereof Sulfated dextran or a salt thereof, fluoromethylhistidine or a hydrochloride thereof, histidine methyl ester or a hydrochloride thereof, licorice extract, sicon extract, age extract, propolis, eye (indigo leaf) extract, asenyaku (asen drug) extract, avocado extract, amadocoro (Bamboo bamboo) extract, Amiga lily extract, Baimo (shellfish mother) extract, Igakozorina (ground bile head) extract, Ibukitoranoo extract, Turmeric (Usu gold) extract, Echinashi (Hosobamurasakibarengiku) extract, Auren (Yoren) extract, Oguruma (turnover) extract, Hypericum persimmon (Brother cut grass) extract, Onigurumi extract, Orange extract, Cassia extract, Kamiyatsude (Tongweed) extract, Kawamidori extract, Kawara mugwort (Cotton chin) extract, Watercress extract, Kenashi Sartori Ibaraki , Gentian extract, co Ukisekoku extract, Kouhon (Kakimoto, Karamoto) extract, Koryokyo (Kora Kaki) extract, Gosho strawberry (covered bonsai) extract, Psycho-ran extract, Cherry extract, Salvia (sage) extract, Diquitaris extract, Linden extract, Salamander extract , Indobodai extract, Shukushamitsu (sand seed, shredded sand) extract, Juzudama extract, White minten (Nanten) extract, Ivy extract, Psyllium extract, Yarrow extract (Milfoil) extract, Shirohagenega extract, Takasago Gorhihitai Extract, Takakawarabi (Spider spine) extract, Periwinkle extract (Rika) extract, Tomatoutsu rafuji extract, Tounin extract, Chigaya extract, Toga (winter coconut) extract, Dokudami (ten-drug) extract, Parsley (Netherlands jelly) extract, Shrimp Shishitsuri extract, Hamasuge (Katsukishi) extract, Hishi (Rhijimi) extract, Bellows oyster extract, Pepper quail (South rattan) extract, Bundou (mung bean) extract, Sandalwood extract, Butcher bloom extract, Pansy extract, Hosoba aragiku (painful) Extract, Mizurutennansho (Tennansei) extract, pheasant (fruit) extract, miracle fruit extract, scented extract, peach (peach) extract, cornflower extract, willow willow extract, mistletoe (willow parasite) extract, Yabukouji (purple gold beef) extract, Porcupine extract, Artemisia (bamboo leaf) extract, Rosemary (Mannenrou) extract, Itohimehagi extract, Futosuzumo extract, Tamajuzumo extract, Mizojuzumo extract, Urushigusa extract, Siwahige extract, Akamok extract, Togemoku extract, Akaba extract, Maruba Aqaba Extract , Spinach extract, dulse extract, una extract, belladonna extract, cypress extract, harimille (crustacean, cinnamon bark, coconut leaf) extract, Aozulan extract, sakaneran extract, sasabagin orchid extract (including varieties and origin species) extract , Valerian extract, primrose extract, senkyu extract, kyonin extract, honeysuckle extract, tokyo extract, fennel extract, peppermint extract, and the like.

Anti-seborrheic agent An anti-seborrheic agent can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of the antiseborrheic agent include chroman derivatives, pyridoxine or salts thereof and derivatives thereof, pyridoxal or salts thereof and derivatives thereof, pyridoxamine or salts thereof and derivatives thereof, sulfur, Asa extract, (Continuous) extract, Dutch mustard (watercress) extract, valerian extract (valerian root) extract, clematis extract, bear sebacekis, savonso extract, rosewood extract, horse chestnut extract, soybean (soybean) extract, Tokinsenka (marigold) extract, Chinese yam Examples include extract, yam extract, nosen-halen extract, dandelion poppy (sect winter flower, sect winter) extract, yabgarashi extract, giant kelp extract, hijirimen extract, primrose extract, haius banori extract.

Antibacterial agent An antibacterial agent can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of antibacterial agents include acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salashi powder , Iodine compounds, iodoform, 1-alkylcarbapenem compounds, N-substituted azepane derivatives or salts thereof, sorbic acid or salts thereof, propionic acid or salts thereof, salicylic acid or salts thereof, dehydroacetic acid, parahydroxybenzoic acid esters, 2 -Keto-3-deoxyoctanoic acid fatty acid esters, inositol deoxy derivatives (such as quercitol), inositol unsaturated derivatives (such as chonditol), inositol dimethyl ether, methyl inositol, inositol methyl ester Ether, inosamine, deoxyinosadiamine, shikimic acid, quinic acid, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol , Thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, Chlorobutanol, isopropylmethylphenol, elemol, vetiverol, patchouli alcohol, nonionic surfactant (polyoxyethylene lauryl ether, polyoxyethylene nonyl pheny Ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, Methylrosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal violet, germal, photosensitive element 101, photosensitive element 201, photosensitive element 401, N-long chain acyl basic amino acid derivatives and acid addition salts thereof, oxidation Zinc, hinokitiol, propolis, kudin extract, agi (Ayu) extract, asunaro extract, alpinia extract, katsudai (suzukuku) extract, Inubilu (Honagainubiu) extract, Aogatei extract, Haribiyueki , Ayuyu extract, Hagateto extract, Hosonagabiyu extract, Enmeiso extract, Warbler extract, Usubasaicin extract, Oshusaishin extract, Halibut extract, Ominae shrimp extract, Kajikazura , Kahoku salamander extract, chamomile extract, linden extract, red linden extract, yellow spider extract, caraway extract, betel extract, beetle extract, cranberry extract, grapefruit extract, celosia flower (chicken flower, chicken crown) extract, Bay bay extract, Koushinbara (monthly flower) extract, Copaiba balsam extract, Yamazakura extract, Edhigarashi extract, Miyaza cherry extract, Yoshino cherry extract, Kasami cherry extract, Kanza cherry extract, sugar beet extract, Sarashinashi Horse (Hemp) Extract, Sikunshi (Mikoshi) Extract, Birch Extract, Cinnamon Extract, Sorrel (Acid Model) Extract, Atlantic Dandelion Extract, Japanese Nezu (Etsumatsu) Extract, Japanese Pepper Extract, Wild Pepper Extract, Soka (Grass) Extract, onion extract, chicory extract, Korean senile (蕪 夷) extract, tsuruna (apricot) extract, tokon (root) extract, leek extract, leek extract, peach extract, patchouli extract, ganbanana (stone carp, (Ranju Shahua) extract, cypress extract, pimenta extract, Hirohakinagusa (bald bald eagle) extract, blackberry extract, hop extract, makuri (marine herb) extract, magnolia sprenger extract, Mizokakushi (half-sided lotus) extract, honey bee Extract, purple (purple) extract, moso bamboo extract, pokeweed (commercial land) extract, yukkae , Lobster extract, Lavender extract, Forsythia extract, Sylar forsythia extract, Prunus nomata extract, Tochaka (Yahazutsu no Mata) extract, Red-breasted extract, Anaanaosa extract, Human egusa extract, Hirohi-no-higusa extract, Ushito exosa extract, Irolo extract , Ishige extract, arame extract, tamamitadaki extract, tambanori extract, katanoori extract, cherry blossom extract, fujimatsumo extract, kawamozuku extract, aokawa mozuku extract, himeka mozuku extract, yakuchi (yachi) extract and the like.

Blood flow promoter / vascular stimulant A blood flow promoter / vascular stimulator can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of blood flow promoters and vascular stimulants include tocopherol or salts thereof and derivatives thereof, tocotrienol or salts thereof and derivatives thereof, cephalanthin, carpronium chloride, eugenol derivatives (acetyleugenol, methyleugenol, methylisoeugenol, ethyl (Eugenol, ethylisoeugenol, eugenol salicylate, etc.), minoxidil, chili pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, L-menthol, camphor, benzyl nicotinate, cinnarizine, trazoline, acetylcholine, verapamil, ectamol , Α-borneol, cyclandelate, nonyl acid wallenylamide, capsaicin, gingerone, assembly extract, garlic extract, carrot extract , Aloe extract, Gentian extract, Toki extract, Ashitaba (Tomorrow) extract, Arnica extract, Ukiyagara (Sanryo) extract, Himewiku extract, Citrus unshiu (Chest) extract, Toucan beetle (coconut) extract, Oyster extract, Persimmon extract, Kina extract, Goldfish hen extract, Anemone beetle extract, Gubijinsou extract, Kouhone (river bone) extract, Burdock (beef bowl, beef coconut) extract, Sagaki Kyo (Yamabachi) extract, Sinalengyo extract, Ginger extract, Shobu (bamboo shoot, radish) extract, Hawthorn extract, assembly (powdered medicinal) extract, Daidai (orange peel) extract, tanjin (dansang) extract, thyme extract, chiketsu carrot (bamboo ginseng) extract, tsurudokudami (what neck crab) extract , Carrot (Yoteba ginseng) extract, Capsicum (bansho) extract, Toki (toll) , Japanese hornworm extract, Natsumikan extract, elderberry (bone-bone) extract, hazelnut (coconut) extract, Hashiridokoro (roth root) extract, mint (light load, light load) extract, Hamabou Fu (hama wind) extract, Higotai extract , Fujimodoki (Chojizakura, Camellia) extract, Black currant extract, Bodaiju (Aoki tree) extract, Merirot extract, Yuzu extract, Loquat extract, Japanese jelly extract, Hibiscus extract, Rosehip extract and the like.

Anti-androgen agent An anti-androgen agent can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of antiandrogens include follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendrone, 4 ′, 5,7-trihydroxy-8-prenylflavanone, 4 ′, 5,7-trihydroxy-8 -Prenyl flavone, 3,3 ′, 4 ′, 5,7-pentahydroxy-8-prenyl flavone, nicorandil, cyclosporine and the like.

Structural proteolytic enzymes (elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme, etc.) Activity inhibitor / structural protein Decomposition enzyme expression inhibitor Cosmetic or quasi-drugs containing the agent of the present invention include structural proteolytic enzymes (elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme) Enzymes, fibronectin-degrading enzymes, matrix metalloproteases such as proteoglycan-degrading enzymes) activity inhibitors / structural protease inhibitors Can be added. Specific examples of structural proteinase activity inhibitors / structural proteinase expression inhibitors include adenine derivatives (butanetriol-9-adenine and its phosphate adduct, propanediol-9-adenine and its phosphate adduct, Pentanetriol-9-adenine and its phosphate adducts), carbostyril derivatives or salts thereof, dicarboxylic acids (glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, 1,9-nonamethylenedicarboxylic acid) Acid, 1,10-decamethylenedicarboxylic acid), rosmarinic acid, ursolic acid, oleanolic acid, hydroxamic acid derivative, esculetin derivative, anthocyanidins, nordihydroguaiaretech acid, 20-carboxy-16-hydroxy-21-nor- 5 α-7,9 (11) -lanostadien-3,24-dione, ubiquinone, plastaquinone, yugro , Shikonin, quinizarin, alizarin, abietin, levopimaric acid, betulin, α-amylin, catechin compounds (catechin, epigallocatechin, epigallocatechin gallate, epicatechin, epicatechin gallate, catechin rhamnopyranoside catechin, etc.), fluoro Diisopropyl phosphate, (2R, 6R) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate, N, N'-bis-[( 1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydroxyheptanedicarboxylic acid-1,7-diamide, (2R, 6R) -2, 6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane- Dimethyl 1,7-dicarboxylate, (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyl Tyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy -4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R)- 2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R)- 2,4,6-Trihydroxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2,6 -Dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, (2S, 6S) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7 Dimethyl dicarboxylate, dimethyl (2S, 6S) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate (2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2S, 6S) -2,6-dibenzyloxy- 4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2, 6-Dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-( 2R, 6R) -2,6-Dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, 3-[[4- (4-fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclopentyl) -Amino] -propionic acid, 4- [4- (4-fluorophenoxy) -benzenesulfonylamino] -tetrahydropyran-4-carboxylic acid hydroxyamide, 4- [4- (4-chlorophenoxy) -benzenesulfonylmethyl] -Tetrahydropyran-4-carboxylic acid hydroxyamide, 3-[[4- (4-fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclobutyl) -amino] -propionic acid, 4- (4'-chloro Biphenyl-4-yl) -2- [2- (1,3-dioxo-1,3-dihydroisoindol-2-yl) -ethyl] -4-oxobutyric acid, 1- [4- (4-fluorobenzyl) Oxy) -benzenesulfonyl] -2-hydroxycarbamoylpiperidin-3-yl) -carbamic acid isopropyl ester, 2- [4- (4-fluorophenoxy) -benzenesulfonylamino] -N-hydroxy-2-methylpropionamide, 3- [4- (4-Fluorophenoxy) -benzenesulfonyl] -2, N-dihydroxypropionamide, 3- (4-phenoxybenzenesulfonyl) -7-oxabicyclo [2.2.1] heptane-2-carboxylic acid hydroxy Amide, (4-benzylbenzyl)-[2- (2,2-dimethyl-1-methyl Rubamoylpropylcarbamoyl) -4- (4'-fluorobiphenyl-4-yl) -butyl] -phosphinic acid, 2-amino-3- [4- (4-fluorophenoxy) -benzenesulfonyl] -N-hydroxypropion Amide, N-Hydroxy-2- (4-phenylpiperidine-1-sulfonyl) -acetamide, Iris extract (Park) extract, guava extract, trash (Gomiko) extract, papaver extract, rose rose extract, Hypericum perforatum extract, chickweed extract , American Grape Extract, European Grape Extract, Yama Grape Extract, Mandarin Extract, Mishima Psycho (Shibahu) Extract, Ou Gon extract, Hypericum extract, Clara extract, Mulberry extract, Keihi extract, Gentian extract, Comfrey extract, Salvia extract, Elderberry extract, Body squirrel extract, Button pi extract, Aos zulan extract, Sakaneran extract, Sasabagin orchid extract, Chinese cabbage extract (variety and origin) (Including seeds) extract, red-green agave extract, sisal extract, garlic extract, and the like.

Structural protein synthesis promoter A structural protein synthesis promoter can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of structural protein synthesis promoters include ethanolamine derivatives, pentoxyphyllin, serine derivatives, geraniol, crocetin, methyl 4- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-4- (3, 5,5-Trimethylhexyloxy) methyl benzoate, methyl 4-cyclohexylmethoxy-2-hydroxybenzoate, methyl 4- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4- (3,7-dimethyl-6 -Octenyloxy) methyl 2-hydroxybenzoate, ethyl 3- (2-ethylhexyloxy) -5-hydroxybenzoate, methyl 5- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-5 -(3,5,5-trimethylhexyloxy) methyl benzoate, methyl 5- (2-cyclohexylethoxy) -2-hydroxybenzoate, methyl 4-N-hexyloxy-2-hydroxybenzoate, 2-hydride Methyl xyl-4-N-octyloxybenzoate, methyl 4-N-decyloxy-2-hydroxybenzoate, methyl 5-N-hexyloxy-2-hydroxybenzoate, 4- (2-ethylhexyloxy) -2- Hydroxybenzoic acid, 2-hydroxy-4- (2,5,5-trimethylhexyloxy) benzoic acid, 4-cyclohexylmethoxy-2-hydroxybenzoic acid, 4- (2-cyclohexylethoxy) -2-hydroxybenzoic acid, 4- (3,7-dimethyl-6-octenyloxy) -2-hydroxybenzoic acid, 3- (2-ethylhexyloxy) -5-hydroxybenzoic acid, 5- (2-ethylhexyloxy) -2-hydroxybenzoic acid Acid, 5- (2-ethylhexyloxy) -2-hydroxybenzoic acid, 2-hydroxy-5- (3,5,5-trimethylhexyloxy) benzoic acid, 5- (2-cyclohexylethoxy) -2-hydroxybenzoic acid Acid, 4-N-hexyloxy-2-hydroxybenzoic acid, 5-N-hexyloxy-2 -Hydroxybenzoic acid, 2-hydroxy-4-N-octyloxybenzoic acid, 4-N-decyloxy-2-hydroxybenzoic acid, N- (2-hydroxyethyl) -4- (2-ethylhexyloxy) -2- Hydroxybenzamide, N-ethyl-4- (2-ethylhexyloxy) -2-hydroxybenzamide, 2-acetoxy-4-cyclohexylmethoxybenzoic acid, 4- (2-ethylhexyloxy) -2-hydroxybenzoic acid sodium, 4- [(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoate methyl, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] Ethyl-2-hydroxybenzoate, 5-[(2E) -3,7 dimethyl-2,6-octadienyloxy] -2-hydroxyethyl benzoate, 3-[(2E) -3,7-dimethyl- Ethyl 2,6-octadienyloxy] -2-hydroxybenzoate, ethyl 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -5-hydroxybenzoate, 4- [(2E) -3,7-dimethyl-2,6-octadienyloxy] -3-methoxybenzoate, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10 -Dodecatrienyloxy] -2-hydroxybenzoic acid methyl, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid (2E) -3,7- Dimethyl-2,6-octadienyl, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid, 5-[(2E) -3,7-dimethyl- 2,6-octadienyloxy] -2-hydroxybenzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid, 3-[(2E ) -3,7-dimethyl-2,6-octadienyloxy] -5-hydroxybenzoic acid, 2-hydroxy-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10 -Dodecatrienyloxy] benzoic acid, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -3-methoxybenzoic acid, 2-acetoxy-4-[(2E) -3 , 7-Dimethyl-2,6-octadienyloxy ] Benzoic acid, N- (2-hydroxyethyl) -4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzamide, 4-[(2E) -3, 7-dimethyl-2,6-octadienylamino] -2-hydroxybenzoic acid, dimethyl-2,6-octadienyloxybenzoic acid, N- (2-hydroxyethyl) -4-[(2E) -3 , 7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienylamino] -2-hydroxybenzoic acid, 3 -Dodecyloxybenzoic acid, 3- (12-hydroxydodecyloxy) benzoic acid, 4-dodecyloxybenzoic acid, 4- (12-hydroxydodecyloxy) benzoic acid, 3- (12-hydroxyoctadecyloxy) benzoic acid, 4 -(12-hydroxyoctadecyloxy) benzoic acid, 3- (11-hydroxyundecyloxy) benzoic acid, 4- (11-hydroxyundecyloxy) benzoic acid, 3-[(2E) -3,7-dimethyl- 2,6- Tadienyloxy] benzoic acid, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, 3-[(2E, 6E) -3,7,11-trimethyl-2,6 , 10-dodecatrienyloxy] benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4- [3,7-dimethyl -9- (2,6,6-trimethyl-1-cyclohexen-1-yl) -2,4,6,8-nonatetraenyloxy] benzoic acid, 4- [3,4-dihydro-2,5, 7,8-Tetramethyl-2- (4,8,12-trimethyltridecyl) -2H-1-benzopyran-6-oxy] benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl -2,6,10-dodecatrienyloxy] benzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzamide, 4- (2-methyl-2-butenyloxy) benzamide 4- (2-ethylhexyloxy) benzamide, 4-dodecyloxybenzamide, 4- (12-hydroxydodecyloxy) benzamide, 4- (12-hydroxyoxy) Tadecyloxy) benzamide, 4- (11-hydroxyundecyloxy) benzamide, 4- (10-hydroxydecyloxy) benzamide, 4-isostearyloxybenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E ) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzamide, N, N-dimethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6, 10-dodecatrienyloxy] benzamide, N, N-di [(2E) -3,7-dimethyl-2,6-octadienyl] -4-aminobenzamide, 4- [N'-methoxycarbonyl-N-[( 2E) -3,7-dimethyl-2,6-octadienylamino] benzamide, 4- [N-acetyl-N-[(2E) -3,7-dimethyl-2,6-octadienyl]] aminobenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, N, N-diethyl-4 -[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyl Xyl] -2-hydroxybenzamide, amine oxides (oleyl dimethylamine oxide, stearyl dimethylamine oxide, palmityl dimethylamine oxide, myristyl dimethylamine oxide, lauryl dimethylamine oxide, dimethyl lauryl ethoxyamine oxide, dihydroxyethyl lauryl amine oxide, Coconut oil alkyldimethylamine oxide, etc.), alkyl betaines (coconut oil fatty acid amidopropyl betaine, coconut oil alkyl betaine, lauryl dimethylaminoacetic acid betaine, lauric acid amidopropyl betaine, lauryl hydroxysulfobetaine, 2-alkyl-N-carboxymethyl -N-hydroxyethylimidazolinium betaine), pyrimidine-N-oxide derivatives (2-amino-4-methyl-6-piperidinopyrimidine-3-oxide) 2-amino-4-methyl-6- (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-6- [1- (4-Methylpiperazinyl)] pyrimidine-3-oxide, 2-amino-4- (1-hexahydroazepinyl) -6-methylpyrimidine-1-oxide, 2-amino-4-dimethyl Amino-6-methylpyrimidine-1-oxide, 2-amino-4-allylamino-6-methylpyrimidine-1-oxide, 2-amino-4-benzylamino-6-methylpyrimidine-1-oxide, 2-amino- 4,5-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-ethyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-5-nitro-6-pi Peridinopyrimidine-3-oxide, 2,5-diamino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-5,6-bis (1-pyrrolidinyl) pyrimidine-3 -Oxide, 2-a Mino-4-methyl-5-piperidino-6- (1-pyrrolidinyl) pyrimidine-3-oxide, 2-methyl-4-amino-6-piperidinopyrimidine-3-oxide, 2-methyl-4-amino- 5-bromo-6- (1-pyrrolidinyl) pyrimidine-3-oxide, 2-methyl-4-amino-5-nitro-6-piperidinopyrimidine-3-oxide, 2-methyl-4,5-diamino- 6-piperidinopyrimidine-3-oxide, 2-methyl-4-amino-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-6-piperidinopyrimidine- 3-oxide monohydrochloride, 2-acetylamino-4-methyl-6-piperidinopyrimidine-3-oxide, 2,4-diamino-6-phenoxypyrimidine-3-oxide, 2,4-diamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitroso-6- (2,4-Dichlorophenoxy) pi Midine-3-oxide, 2,4-diamino-5-nitro-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2,4 -Dichlorophenoxy) pyrimidine-3-oxide, 2,4,5-triamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-bromo-6- (2,4 -Dichlorophenoxy) pyrimidine-3-oxide, etc.), p-menthane-3,8-diol, monoglyceryl-D-glucoside monotridecanoate, 1-oN-pentadecylglycero-D-glucoside, monopentadecane Glyceride sulfate such as acid glyceride sulfate, monopentadecyl glyceryl ether sulfate, 1-o-hexadecyl-2-o-methylglycerol, 1-o-octadecyl-2-o-methylglycerol, 1-o-oleyl-2-o-methyl glycerin, pea extract, tossed extract, squid extract, Ibonori extract, Novonori extract, Igis extract, Keigi extract, Harigi extract, Hanegi extract, Usbawa eustoma extract, Moroitogusa extract, Fuyugususa extract, Weeping willow extract, Willow extract, Moyuyurena extract, Vulture extract, Mosaiyanagi extract , Sasabayanaginori extract, wasabi extract, merbou extract and the like.

Mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitor Addition of mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitor to cosmetics or quasi drugs containing the agent of the present invention Can do. Specific examples of mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitors include anacardic acid or its derivatives (6-pentadecatrienylsalicylic acid methyl ether, 6-pentadecatrienylsalicylic acid ethyl ether, 6-pentadecaic acid). Trienyl salicylic acid propyl ether, 6-pentadecatrienyl salicylic acid butyl ether, 6-pentadecatrienyl salicyl alcohol methyl ether, 6-pentadecatrienyl salicyl alcohol ethyl ether, 6-pentadecatrienyl salicyl alcohol propyl ether, 6- Pentadecatrienyl salicyl alcohol butyl ether, 6-pentadecatrienyl salicylaldehyde methyl ether, 6-pentadecatrienyl salicylaldehyde ethyl ether, 6-pentadecatrienyl salicylaldehyde Propyl ether, 6-pentadecatrienyl salicylaldehyde butyl ether, 2-methyl ether-6-pentadecatrienyl cinnamic acid, 2-ethyl ether-6-pentadecatrienyl cinnamic acid, 2-propyl ether-6- Pentadecatrienyl cinnamate, 2-butyl ether-6-pentadecatrienyl cinnamate, 2-methyl ether-6-pentadecatrienyl cinnamate alcohol, 2-ethyl ether-6-pentadecatrienyl cinnamate Alcohol, 2-propyl ether-6-pentadecatrienyl cinnamic alcohol, 2-butyl ether-6-pentadecatrienyl] cinnamic alcohol, etc.), polyisoprenylated benzophenone derivatives (garcinol, isogarcinol, xanthothymol) , Isoxanthothymol, gucciferon, etc.), Ikarisou extract, Yachima Taikiso (Inyo) (October) extract, Narco lily extract, Occidental lily (Yellow spirit) extract, Oregano extract, Oshida extract, Onji extract, Spruce extract, Crow birch extract (half-summer) extract, Pheasant extract Skin) extract, goshyu extract, senega extract, sendan extract, tamarind extract, tarragon extract, ginkgo biloba extract, bee extract, daisy extract, mirabaran extract, himebara extract, Mockin Extract, Laurel Extract, Yabusotatsu Extract, Anaaaosa Extract, Macrocystis Integrifolia Extract, Neocitus Ruetkeana Extract, Nettle Extract, Prunus Extract, Kata-Bucka Extract, Yatabegusa Extract, Shimatengusa Extract, Ezotsunomata Kisses, Swallowtail extract, Fusiwa ivy extract, Hanemo extract, Mill extract, Chromel extract, Nagamil extract, Hiramil extract, Matsumo extract, Okinawa mozuku extract, Mozuku extract, Fukuronori extract, Kajime extract, Orochi nori extract, Mafnori extract, Grape leaf extract, Salamander extract, Astragalus extract etc. are mentioned.

Mucopolysaccharide synthesis promoter A mucopolysaccharide synthesis promoter can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of the mucopolysaccharide synthesis accelerator include stilbene derivatives or salts thereof, morgin or salts thereof and derivatives thereof, N-acetylglucosamine, flax extract, cinnamon extract, mulberry extract, scotch extract, breadfruit extract, hirakotoji extract , Kotojitsu no Mata Extract, Yaleus Banori Extract, Kagiosu Banori Extract, Susius Banori Extract, Amiaosa Extract, Nagaaosa Extract, Hosobanosakamodoki Extract, Hirohatosakamodoki Extract, Yatsudegatatosakamodoki Extract, Kurotosakamodoki Examples include extract, Nezushinosakamodoki extract, Yusora extract, Etsukinotosakamodoki extract, Nankaitosakamodoki extract, Himetosakamodoki extract, and the like.

Intercellular lipid production promoter / intercellular lipid state improver An intercellular lipid production promoter / intercellular lipid state improver can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of intercellular adipogenesis promoters and intercellular lipid state improvers include phospholipids (phosphatidylethanol, phosphatidylcholine, phosphatidyltriethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylglycerin, phosphatidylinositol, diacylphosphatidylcholine, diacylphosphatidylethanol Amine, diacylphosphatidylinositol, diacylphosphatidylserine, 1-cysteinylphosphatidic acid, 2-cysteinylphosphatidic acid, 1-glutathionylphosphatidic acid, 2-glutathionylphosphatidic acid, 1-azelaoylphosphatidic acid, 2- Azela oil phosphatidic acid, 1-hydroxyacyl phosphatidic acid, 2-hydroxyacyl phosphatidic acid, ceramide, glucosyl Lamide, galactosylceramide, cerebroside, phosphatidylglucosylacylglycerol, N-oleoylsphingosine, N- (12-hydroxyoctadecanoyl) sphingosine, N- (16-hydroxyhexadecanoyl) sphingosine, N-salicyloylphytosphingosine, Sphingomyelin, soybean lecithin, egg yolk lecithin, etc.), sterins (cholesterol, dihydrocholesterol, cholesteryl stearate, cholesteryl hydroxystearate, macadamia nut oil fatty acid cholesteryl, β-sitosterol, stigmasterol, campesterol, ergosterol, 5-dihydro Ergosterol, phytosterol, 25-hydroxycholesterol, 26-hydroxycholesterol, 19-hydroxycholesterol, 22-ketocholes Roll oxime, 6-ketocholesterol and 7-ketocholesterol or their derivatives), N-acetylneuraminic acid (sialic acid), N-glucosolneuraminic acid, gangliosides (gangliotriose, gangliotetraose , Globotetraose, neolactotetraose, neolactohexaose, neolactooctaose, etc.), oligosulfated hyaluronic acid, hydroxytamoxifen compounds, glyceroglycolipids, pentoxyphyllin, 3-deazaadenosine, carboxamide derivatives, Inositol polyamines, sialic acid, triterpenic acid derivatives, lactose, lactosamine derivatives, sulfated chitin derivatives, albumin, ginseng extract, tochiban ginseng extract, sea cucumber extract, red lily extract, green lily extract, chickweed extract And the like.

Keratin solubilizer / horny layer exfoliation accelerator A cosmetic or quasi-drug product containing the agent of the present invention may contain a stratum corneum solubilizer / keratin layer exfoliation accelerator. Specific examples of keratolytic agents and stratum corneum exfoliation accelerators include tropolone and its derivatives, resorcin, lactic acid, urea, salicylic acid, guanidine, ethanolamine, kikarasuuri (Gurone) extract, fenugreek extract, wisteria bean extract, lentil extract Chickpea extract, mungbean extract and the like.

Plasminogen activator antagonist inhibitor A plasminogen activator antagonist inhibitor can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of the plasminogen activator antagonist inhibitor include rabbit daisy extract, canamgra extract, caladium extract, raspberry extract and the like.

Maillard reaction inhibitor A Maillard reaction inhibitor can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of Maillard reaction inhibitors include aminoguanidine, flavanones (naringin, naringenin, liquiritin, liquiritigenin, digallic acid, luteoic acid, ellagic acid, chlorogenic acid, glucogallin, tetralin, hamamelitannin, gallic tannin, tannic acid, (Geraniin, gallic acid, galloyl gallic acid, ellagitannin, hexagalloyl glucose, heptagalloyl glucose, tetragalloyl glucose, triggerroyl glucose, pentagalloyl glucose, digalloyl quinic acid, triggerroyl quinic acid), 2-hydroxyphenylalkylamine Derivatives or salts thereof, phenylpropenoic acid derivatives (3- [2,3-bis (methoxymethoxy) phenyl] propenoic acid, 7- (4-hydroxy-3-methoxyphenyl) hepta-2,4,6-trienoic acid, 3- (3,5-Dimethoxy-4-hydroxy (Roxyphenyl) propenohydrazide, N'-isopropylidene-3- (2-methoxyphenyl) propenohydrazide, etc.), citric acid or its salts, gypsum extract, sandalwood extract, red clover extract, persimmon (柿) (Including moths) Examples include Tarayo extract, Dokudami extract, Tormentilla extract, Bakumondo extract, Hiba extract, Grape extract, Japanese willow extract, Mukuroji extract, Karin extract, Mokka extract, Roman chamomile extract and the like.

Hair matrix growth inhibitor / hair growth inhibitor A hair matrix growth inhibitor / hair growth inhibitor can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of hair matrix growth inhibitor / hair growth inhibitor include phthalazinones, benzoxazinones, phosphonic acid derivatives, cyproterone, 5α-androstene-3α, 17β-diol, medroxyprogesterone, norethisterone, methanolone, and ichihatsu (First) extract, citrus extract, kanto extract, sanjiko extract, silamo extract, sardine extract, scabbard fern extract, fritillary extract, honeysuckle extract, seaweed extract, oleander extract and the like.

Hair swelling agent / hair protecting agent A hair swelling agent / hair protecting agent can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of the hair swelling agent / hair protecting agent include ethanolamine, urea, guanidine, silicones, blueberry extract, mango extract and the like.

Odorant-eliminating agent An odorant-eliminating agent can be added to cosmetics or quasi drugs containing the agent of the present invention. Specific examples of the odorous substance eliminating agent include Inondo extract, Elemi extract, vanilla bins extract, pine extract and the like.

Other Additive Components Specific examples of ingredients derived from plant-based materials used as additives other than those described above for cosmetics or quasi drugs containing the agent of the present invention include: Extract, Aquine (Crustacea) Extract, Aguay Guassu Extract, Abiyu Extract, Abiurana Extract, Yellow Sapote Extract, Ylang Ylang Extract, Uranium Extract, Uba Tea Extract, Ezo Lilac Extract, Unboku Extract, Elderberry Extract, Ohisano Yuki Extract , Sasanoyuki Extract, Toucan Cactus Extract, Omiya Catez Extract, Onoelan Extract, Crab Extract , Kiraja saponaria extract, ginseng extract, kimbsen extract, guapeba vermelha extract, kugenumaran extract, gooseberry extract, crity river extract, curcrigo latifolia extract, kuroganemochi (rescue) extract, sapotea mariyo extract, salmon berry Extract, Salamander Extract, Sancactus Cactus Extract, Salamander Extract, Shunran Extract, Shozukku Extract, Shirubanatsuta Extract, Cinchona Silla Bra Extract, Swimberry Extract, Star Apple Extract, Sulgaran (Oran) Extract, Scots Pine Extract, Cypress extract, scallop extract, mistletoe extract, sennin cactus extract, senboku extract, elephant shoot extract, prunus extract Somer potato extract, dark sweet cherry extract, prickly pear extract, choco nostay extract, ginseng extract, tsukushi kaneran extract, tsuchikebi extract, tsuyukusa (duck moth grass) extract, duberry extract, tiger moth extract, tragacanth extract , Triacanthus extract, Neiseria berry extract, Rapeseed extract, Plover dough extract, Pau doce extract, Hackleberry extract, Batata extract, Hamakakiran extract, Balata extract, Harcan orchid extract, Pecan nut extract, Chicknut extract, Himemulan orchid extract, Brazilian carrot extract, Branjen extract, Frucereria extract, Blond psyllium extract, Hetsukaran extract, Henken extract, Berry extract, Percea extract, Pervianburg Extract, Pereschia grandifolia extract, Boysenberry extract, Hosairan extract, Pouteria sapota extract, Pouteria rukuma extract, Hosobabarengiku extract, Whataberry berry extract, Masaransuba extract, Masheira de Boyi extract, Matta auryo extract, Mulberry extract, green potato extract, purple corn extract, megacansa opuntica extract, mokukirin extract, Japanese maple extract, Morero cherry extract, Yakawa potato extract, cornflower mint extract, Ruritama thisami (Vultures) Extract, red pitaya extract, lemongrass extract, wax palm extract, logan berry extract, arakashi extract, angelica extract, apricot extract , Hong anzu extract, Ichiyakusou (one herb) extract, Enishida extract, psyllium (car pupae, car forerunner) extract, Psyllium extract Striped anteater extract, ginseng extract, cattle pea extract, cucumber nut extract, camphor extract, kubeba extract, buckthorn extract, oyster extract ) Extract, Sanecazu extract, Vinangkazura extract, Matsubusa extract, Colombo extract, Condurango extract, Sasanqua extract, Sweet potato extract, Sanebuto jujube , Sandskon extract, Potato extract, Shishigashi extract, Sanshishi extract, Coriander extract, Stevia extract, Takatodai (Otsuchi) extract, Tarayo (Oba winter blue, Ichiha tea, bitter tea, bitter tea) extract, Taranoki extract , Nigaki (Nakiki) extract, Nurde (pentapod) extract, Hakamaurabosi (bone crushing) extract, Hamakokuren extract, Smoke squirrel extract, Carp serrata extract, Prunus serrata extract, Mangosteen extract, Mangosteen extract , Myouga extract, Melaleuca extract, Yachabushi extract, Himeya Shabushi extract, Obaya chabushi extract, Yakumoso extract, Yamahanoki (Yamatake) extract, Longan (longan) extract, Lokon (Yoshi, Sone) extract, Logwood extract, Lantana extract And plant extracts such as

  Specific examples of ingredients derived from plant-based materials used as additives other than those described above for cosmetics or quasi-drugs formulated with the agent of the present invention include Dunaliella genus Dunaliella extract, Kuwanomimo kuwanomimo extract, Volbox genus Mawari extract, Volbox genus Volbox extract, Palmera extract, Jupiter extract, Aomido spp. Genus Suricho moth extract, Magnus genus Heraiwa moth extract, Magama genus Black fox moth extract, Casanori genus Casanori extract, Mika moth extract, Collecaete extract, tsutsumi imo extract, Kikumogusa kid Green algae extract such as gussa extract, Sayamidro extract, Kunshomo extract, Sumiremo violet reed extract, Hosimidro extract, Fuchinashimidoru extract, cyanobacteria genus Suizendinori extract, blue-green algae extract such as Aoko extract, Yuremo extract, Piraella genus Piraela extract, Shiomidomo genus Nagamisio , Isovine genus Isovine extract, Isogawala genus Isogawara extract, Black moth genus Black moth moth extract, Kashirazaki genus Kashirazaki extract, Muchimo genus Muchimo extract, Muchimo genus Hiramchimo extract, Muchimo genus Quercus cricket extract, Amygusa genus Sakibiro amiji extract, Common genus Common gussa Extract, Jingamusa Genamigusa Extract, Namimakura Hirunamamikura Extract, Someraceae Somerna Extract, Navaimo Navarimo Extract Chasomen genus Chasumen extract, Nagamatsumo genus Nagamatsumo extract, Niseft mozuku niseft mozuku extract, Fumozoku genus mozuku extract, Kuromo genus kuromo extract, Nisemo genus Nisemozuku extract, Ichimosa genus Ichimegasa extract, Echinacea genus Quercus genus Urushigusa Tobacco Rabbit Extract, Rhizoma spp. Genus shark extract, weeping weeping weeping manori extract, crayfish genus cresting extract, genus fennel extract, cranula Brown genus extract such as genus Culmo extract, Kajime genus Chlome extract, Chrysanthemum genus Chrysanthemum humus extract, Uchimo genus Oukimo extract, Buruki genus Burukimo extract Amanori Benitasa Extract, Rhodocorton Milnobeni Extract, Konahada Hykonahada Extract, Konahada Yokorekonahada Extract, Konahada Aokona Hada Extract, Cyprinus genus Tsukumonori Extract, Cyprinus genus Camellia extract, Kasamatsu Kasa Niphusanori genus Nusafusanori extract, Sodegarami genus Sodegarami extract, Hirohata Tadaki genus Hiromata Tadaki extract, Tengusa Nambugusa extract, Tengusa kohira extract, Ngusa genus yohira extract, Tengusa genus extract, Hibiro hibishirodo extract, Hibiro genus hibishirodo extract, Rhizoma genus Rhizoma genus extract, Rhizome genus Ryumonsou extract, Ryumonso genus Ryumon sera Genus Nigella cricket extract, Okibara genus Giant rose extract, Coral spruce genus Ragalamado extract, Shiogusagoromo genus Shiogusagoromo extract, Iwanokawa genus Ikiiwakawa extract, Kainokawa genus Kinokawa extract, Canninote genus Cinote extract, Sangomo Genus scum cadaver extract, centipede spruce extract, centipede spruce extract, centipede spider extract, centipede vine Extract, centipedeus genus extract, centipede genus marbahudara extract, cypress genus extract Kintoki Fushikintoki extract, Kintoki tsunomukade extract, Kintoki nagakintoki extract, Kintoki Sumimukade extract, Kakateto Obakintoki extract, Nagaobane spp. , Tsukasanoori Otsukasanori extract, Tsukasanori Hanagakarimenia extract, Hounoho Honoo extract, Hikeno genus Hikageno Extract, Chrysalis spp. Atsubanori extract, Ogonori genus Ogonori extract, Ogonori genus Beniogonori extract, Ogonori genus Fukushinori extract, Ogonori genus Murasaki birch extract, Ogonori shinkaibanori extract, Ogonori genus bonito extract, Ogonori genus Katagogonori extract Genus Ryukyu Ogonori Extract, Ogonori Ogonori Extract, Ogonori Ittsuginu Extract, Ogonori Yumigataogonori Extract, Ogonori Kubireogonori Extract, Ogonori genus Mosaogonori extract, Ogonori genus moth birch extract, Namiiwatake namiiwatake extract, Saimi genus extract, Saimi genus extract, Lotus japonica genus extract, Chrysanthus genus extract Spikelet Extract, Spiraea spp. Scorpion extract, Dulcus anadalus extract, Weibusa genus Bugasca extract, Benifuro genus Benifu kuronori extract, Snapdragon genus Kiss, Otium Echinacea Extract, Egonori Egonori Extract, Egonori Futogisu Extract, Saeda Saeda Extract, Chrysanthemum Chilli Momiji Extract, Habutaenori Extract, Konohori Extract, Suzuronori Extract, Usbenius Usbeni Extract, Hasujigigi Hasujiginu Extract, Nagakonohanoga Nagakonohanori Extract, Sugiginus Sugiginu Extract, Sugiginu Atsubasujiginu Extract, Hyus Banori Kagious Banori Extract, Heius Banori Yaleus Banori Extract, Haius Banori Extract Suiusus Banori Extract, Haius Banori Extract Norimodoki genus extract, Ayanishiki genus Ayanishiki extract, Ayaginu genus Ayaginu extract, Dadia genus Enasidia extract, Shimadadia genus Isohagieki , Shimadadia spp. Himegoke Extract, Hyodosigmus Chrysanthemum Extract, Hyodosighis Hyodosigusa Extract, Hyodosigus Usubahiodori Extract, Isomegusa Isomegusa Extract, Suzynagususa Susujinashigusa Extract, Isobashousu Isobago Extract, Ideyugogome Ideyu Red seaweed extract such as Ochimomozuki Okichimozu extract, Chisujinori Chisujinori extract, Shajikumo extract, Shiratamamo extract, Hoshitsurimo Hoshitsurimo extract, Riku Axalae extract such as Notamnus extract, Flask extract, Chaboflask extract and Tripella extract, Yellow algae extract such as Hikarimo Hikarimo extract and the like.

  Specific examples of ingredients derived from animal materials used as an additive to cosmetics or quasi drugs containing the agent of the present invention include chicken crown extract, cow, pig or human placenta extract, pig or cow stomach, duodenum , Intestine, spleen extract or degradation product thereof, bovine or porcine brain tissue extract, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolysate, water-soluble elastin derivative, keratin And its degradation products or their derivatives, silk proteins and their degradation products or their derivatives, porcine or bovine blood cell protein degradation products (globin peptides), cattle or porcine hemoglobin degradation products (hemin, hematin, hem, protohem, hem Iron, etc.), milk, casein and its degradation products or their derivatives, skim milk powder and its degradation products or their derivatives, lactofer Phosphorus or its degradation products, chicken egg components, fish meat degradation products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid) and the like.

  Specific examples of components derived from microbial raw materials used as additives to cosmetics or quasi drugs containing the agent of the present invention include yeast metabolites, yeast extract, bacterial metabolites, bacterial extract, mold or Metabolites such as mushrooms, actinomycete metabolites, extracts such as fungi or mushrooms, actinomycetes extract, natto fungus metabolites, natto extract, rice fermented extract, rice bran (red koji, birch) fermented extract, euglena extract or Examples thereof include decomposition products thereof, water-soluble derivatives thereof, lactic acid fermented products of raw milk or skim milk powder, and the like.

  As the plant, animal, or microbial raw material, any site, cell, tissue, organ, metabolite, etc. derived from a transgenic body or a cell fusion can be used. Specifically, in the case of plant-based materials, at least flowers, styles, male flowers, female flowers, spikes, head flowers, pericarp, fruit skin, fruits, stems, leaves, branches, branch leaves, stems, bark, roots, rhizomes, roots Extraction is performed using at least one site selected from skin, seeds, and the like. Furthermore, it can be obtained by culturing cells of any site, cell, tissue, organ, etc., for example, cultured cells derived from each tissue (cultures derived from animals such as fibroblasts, Langerhans cells, macrophages, epidermal cells, hepatocytes, etc.) Cells, etc.), undifferentiated cells, cells in the middle of differentiation, metabolites thereof, and the like can also be used.

  Specific examples of the ingredients of the natural product raw materials used as additives include seawater such as deep sea water, for example, sea salt, dried sea water, dead sea or Atlantic or Pacific sea water (sodium chloride, chloride). Magnesium, potassium chloride, etc.), sea mud or mud (Fango), for example, sea mud or mud in various places such as Italian Fango, German Fango, Eifel Fango, Freiburg Fango (Containing components: silicon dioxide, titanium dioxide, aluminum oxide, Iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone Natural smectite, bentonite, hectorite and the like.

  Extracts derived from plant raw materials, animal raw materials, microbial raw materials, and other natural product raw materials used as additives are processed in a conventional manner according to the product type and form to be added (for example, pulverization, milling, Treatment, extraction, decomposition, fermentation or metabolic conversion by microorganisms, fractionation, purification, pressing, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. ) And any one of various materials may be selected for use.

  The solvent used for the extraction may be selected in consideration of the purpose of use, the type of product to be blended, the processing performed later, etc., but usually water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, Lower alcohol such as isobutanol or hydrous lower alcohol, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1 , 3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, 1,2-hexanediol, 1,5-hexanediol, 1,6-hexanediol, pentylene glycol, hexylene glycol , Polyhydric alcohols such as glycerin and polyethylene glycol (molecular weight 100 to 100,000) or hydrous polyhydric alcohols, Various organic solvents such as seton, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, carbon tetrachloride, phenol, toluene, and acids prepared with appropriate normality (hydrochloric acid, sulfuric acid, It is desirable to use one or a mixture of two or more selected from nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.). However, when it is not preferable to contain a solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it may be used alone or in any mixture with water. It may be extracted after squeezing.

  Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. The temperature of the solvent can be arbitrarily set in the range of −4 ° C. to 100 ° C., but is preferably around 10 to 40 ° C. from the viewpoint of the stability of the components contained in the raw material. Further, the weight ratio of the solvent to the raw material can be arbitrarily set within the range of, for example, raw material: solvent 4: 1 to 1: 100, and a weight ratio of 1: 1 to 1:10 is particularly preferable.

  Decomposition mainly includes acid decomposition, alkali decomposition, enzyme decomposition, and high-temperature and high-pressure decomposition. In the decomposition with an acid, for example, it is preferable to use an inorganic acid or an organic acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, oxalic acid, hydrogen bromide, perchloric acid, and periodic acid. In the decomposition by alkali, for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, barium hydroxide, sodium carbonate, ammonium carbonate, calcium carbonate, magnesium hydroxide, sodium silicate, etc. are preferably used. In the decomposition with acid or alkali, the concentration, reaction time, reaction temperature, and the like can be arbitrarily set for the target raw material. In the enzymatic degradation, it is preferable to use an enzyme having a function of degrading proteins, polysaccharides, lipids or complexes thereof having an important function particularly with respect to cell structure, tissue structure, etc., for example, aminopeptidase, dipeptidase, dipeptide Peptidyl peptidase, tripeptidyl peptidase, carboxypeptidase, serine protease, trypsin, chymotrypsin, cysteine protease, thiol protease, papain, aspartate endopeptidase, metalloendopeptidase, bromelain, thermolysin, pronase, pepsin, rennin, pan Proteolytic enzymes (proteases) such as creatine, chymopapain, ficin, collagenase, elastase, amylase, takaamylase, cellulase, hemicellular Polysaccharide-degrading enzymes such as pectinase, polygalacturonase, dextranase, planarase, chicken egg white lysozyme, human lysozyme, papaya lysozyme, turnip lysozyme, barley lysozyme, zymolyce, lysozyme chloride, glucanase, chitinase, etc. Cell wall lytic enzyme. In the degradation with an enzyme, the concentration, reaction time, reaction temperature, pH of the solution, etc. can be set arbitrarily, but it is particularly preferable to set the optimum value for the enzyme used.

  Fermentation or metabolic conversion by microorganisms can be performed by inoculating and growing at least one kind of microorganism on a raw material used as a substrate. Inoculation of microorganisms to the substrate can be done by adding microorganisms directly into the substrate, or by adsorbing them on a carrier such as alginic acid, polyvinyl, gelatin, etc., for example, in the form of fine beads composed of microorganisms and carrier. Further, it can be used by being fixed to the tube wall of the bioreactor. Fermentation or metabolic conversion by microorganisms is not particularly defined as a microorganism to be used, but can generally be defined as microorganisms other than pathogenic microorganisms that exhibit significant toxicity to living bodies. Examples of microorganisms to be used include microorganisms classified into yeasts: Aciculoconidium, Actonia, Aessosporon, Ambrosiozyma, Anthomyces, Apiotrichum, Arthroascus, Arxula, Ashbia, Ashbya, Asporomyces, Atelosaccharomyces Genus, Azymoprocandida, Babjevia, Ballistosporomyces, Bensingtonia, Blastobotrys, Blastodendrion, Blastoderma, Blastoschizomyces, Botryoascus, Botryozyma, Brettanomyces, Brettanomyces bruno, Cullus Genus (Candida albicans, Candida amylolenta, Candida anomala, Candida boidinii, Candida entomaea, Candida etchellsii, Candida famata, Candida fermentati, Candida guilliermondii, Candida halophila, Candida krusei, Candida krusei, Candida krusei, Candida krusei, Candida krusei Candida sake, Candida tropicalis, Candida versatilis, Candida vulgaris, etc.), Castellani Genus a, Chlamydozyma, Chromotorula, Citeromyces, Cladosporium, Clavispora, Crebrothecium, Cryptococcus, Debaryomyces (Debaryomyces delbrueckii, Debaryomyces halotolerans, Debaryomyces hansenii etc.), Deberoozyma, Debaryozyma, Dipodascus, Eeniella, Endomyces, Endomycopsis, Eremascus, Eremothecium, Eutorulopsis, Fabospora, Fellomyces, Filobasidium, Galactomyces, Geotrichoides, Geotrichum, Guilliermondella, anomala, Hansenula kluyveri, Hansenula miso, Hansenula polymorpha, Hansenula wickerhamii etc.), Hypomyces, Issatchenkia, Kloeckera (Kloeckera brevis, Kloeckera fluoresceny, Kloeckera Etc.), Kockovaella genus, Kurtzmanomyces genus, Leucosporidium genus, Lipomyces genus, Metschnikowia , Microanthomyces genus, Monilia genus, Monospora genus, Monosporella genus, Mrakia genus, Myceloblastanon genus, Mycocandida genus, Mycoderma genus, Mycotorula genus, Mycotoruloides genus, Myxozyma genus, Nadsonia sp Genus, Oospora, Oosporidium, Pachysolen, Parasaccharomyces, Paratorulopsis, Parendomyces, Petasopsora, Pichia (Pichia amylophila, Pichia farinosa, Pichia guilliermondii, Pichia membranifaciens, Pichia moc Genus, Proteomyces genus, Pseudomonilia genus, Pseudosaccharomyces genus, Pseudozyma genus, Rhodomyces genus, Rhodosporidium genus, Rhodotorula genus, Saccharomyces genus (Saccharomyces aceti, Saccharomyces cerasi, Saccharomyces cerevisiae Genus, Saturnispora, Schizoblastosporion, Schizosaccharomyces, Schwanniomyces Selenotila genus, Selenozyma genus, Smithiozyma genus, Sporidiobolus genus, Sporobolomyces genus, Sporothrix genus, Stephanoascus genus, Sterigmatomyces genus, Sympodiomyces genus, Symingospora genus, Tetrapisispora genus, Torulaspora genus, Tordenpostomy genus, Torulopsiron genus, Torulopsisces genus Genus William, genus Williamopsis, genus Wingea, genus Xanthophyllomyces, genus Yamadazyma, genus Zendera, genus Zygofabospora, genus Zygopichia, genus Zygosaccharomyces, genus Zymodebaryomyces and the like. The microorganisms classified as bacteria include the genus Acetobacter (Acetobacter aceti, etc.), Achromobacter genus, Acidianus genus, Acidobacterium genus, Acidithiobacillus genus, Acrocarpospora genus, Actinoalloteichus genus, Actinocorallia genus, Actinokineospora genus, Actinomadospura genus, Actinomadspura Actinosynnema genus, Aerococcus genus, Aeromicrobium genus, Agrobacterium genus, Agromyces genus, Ahrensia genus, Alcaligenes genus, Alicyclobacillus genus, Alloiococcus spp. Aureobacterium genus, Azotobacter genus, Bacillus genus (Bacillus brevis, Bacillus subtilis etc.), Bacteroides genus, Beneckea genus, Bifidobacterium genus (Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis etc.), Brachybacterium genus, Brevicillus genus, Brevicillus, Brevundimonas, Burkholderia, Carnobacterium, Catellatospora, Cellulomonas sp Enterobacter sp Genus, Halobacterium genus, Halococcus genus, Herbidospora genus, Hydrogenophilus genus, Hyphomicrobium genus, Hyphomonas genus, Intrasporangium genus, Janibacter genus, Kinesia spp. Kocuria, Kurthia, Lactobacillus (Lactobacillus rimae, Lactobacillus divergens, Lactob acillus carnis, Lactobacillus piscicola, Lactobacillus acidophilus, Lactobacillus amylophilus, Lactobacillus animalis, Lactobacillus brevis, Lactobacillus casei, Lactobacillus curvatus, Lactobacillus bulgaricus, Lactobacillus delbrueckii, Lactobacillus fermentum, Lactobacillus fructivorans, Lactobacillus fructosus, Lactobacillus helveticus, Lactobacillus hilgardii, Lactobacillus homohiochii, Lactobacillus kefiri , Lactobacillus malefermentans, Lactobacillus murinus, Lactobacillus paracasei, Lactobacillus paracasei subsp. tolerans, Lactobacillus parakefiri, Lactobacillus pentosus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus sakei, Lactobacillus confusus, Lactobacillus viridescens, Lactobacillus johnsonii, Lactobacillus viscosus, Lactobacillus fermentatae, Lactobacillus acidophil-aerogenes, Lactobacillus leichmannii, Lactobacillus gasseri, Lactobacillus bifidus, Lactobacillus jugurt, Lactobacillus caucasicus Lactobacillus arabinosus, Lactobacillus kunkeei, Lactobacillus nagelii, Lactobacillus fornicalis, Lactobacillus pentoaceticus, Lactobacillus xylosus, Lactobacillus minutus, etc.), Leuconostoc genus (Leuconostoc lactis, Leuconostoc dextranicum, Leuconostoc mesenteroides, Leuconostoc oenos, Leuconostoc paramesenteroides, Leuconostoc cremoris, such as Leuconostoc citrovorum), Listonella Genus, Lucibacterium genus, Luteococcus genus, Magnetospirillum genus, Marinilabilia genus, Marinospirillum genus Mesorhizobium genus, Metallosphaera genus, Methylobacterium genus, Microbispora genus, Micrococcus genus, Microellobosporia genus, Micromonospora genus, Mycobacterium genus, Nocoides genus, Noiaides Genus, Nonomuria, Oceanospirillum, Ochrobactrum, Oerskovia, Oligella, Paenibacillus, Pediococcus (Pediococcus cerevisiae, Pediococcus pentosaceus, Pediococcus urinae-equi etc.), Pedobacterto, Pedobacterto , Planobispora, Planococcus, Planomonospora, Prevotella, Propionibacterium, Proteus, Protomonas, Pseudomonas, Pseudonocardia, Rahnella, Rarobacter, Rathayibacter, Rhizobium, Rhizomonas , Rhodospirillum genus, Rothia genus, Rubrobacter genus, Ruegeria genus, Saccharomonospora genus, Saccharothrix genus, Serratia genus, Sinorhizobium genus, Sphingobacterium genus, Sphingomonas genus, Sporolactobacillus genus, Stenotrophomonas genus, Streptoalloteococ genus Streptoalloteococ faecium, Streptococcus bovis, Streptococcus equinus, Streptococcus mutans, Streptococcus salivarius, Streptococcus thermophilus, Streptococcus agalactiae, Streptococcus mitis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus lactisdy uberis, Streptococcus cremoris, Streptococcus diacetilactis, etc.), Streptomyces genus, Streptosporangium genus, Streptoverticillium genus, Terrabacter genus, Thermoactinomyces genus, Thermobifida genus, Thermobispora genus, Thermohispera genus, Thermohispa genus, Thermopispa genus, Thermopispa genus, Thermopispa genus Genus, Xanthobacter genus, Xanthomonas genus, Zymomonas genus and the like. Microorganisms classified as non-yeast ascomycetes, basidiomycetes or incomplete fungi include Allomyces, Amoebidium, Amorphotheca, Arthroderma, Ascoidea, Ascobolus, Ascodesmis, Aspergillus, Aureobasidium, Botryosphaeria Botryotinia sp Genus, Dothidea genus, Endogone genus, Entomophthora genus, Emericella genus, Eupenicillium genus, Eurotium genus, Exobasidium genus, Gibberella genus, Glomus genus, Graphiola genus, Gymnoascus genus, Harpella genus, Helicomyces genus, Helvella genus, Hemicarpenteles genus, Hyphochytrium genus, Hyphochytrium Hypocrea, Laboulbenia, Labyrinthula, Leptosphaeria, Leptosphaerulina, Lophodermium, Melanotaenium, Microascus, Microstroma, Medeololaria, Melampsora , Melamsporella, Morchella, Monascus, Monilinia, Mycospharella, Nannizzia, Nectria, Neolecta, Neurospora, Nodulosphaeria, Olpidium, Peziza, Penicillium, Perenospora, Pestopolisis Genus, Pneumocystis genus, Preussia genus, Pleospora genus, Puccinia genus, Pythium genus, Ravenelia genus, Rickia genus, Rhinocladiella genus, Rhizidiomyces genus, Rhizoctonia genus, Sclerocleista genus, Saprolegnia genus, Sclerotinia genus, Sclerotum genus, Septobasidium genus, Septobasidium genus Examples include the genus Sporidiobolus, Stigmatomyces, Sydowiella, Talaromyces, Taphrina, Thraustochytrium, Tolyposporium, Trichoglossum, Trichoma, Ustilago, Verticillium, Xylaria and the like.

  In fermentation or metabolic conversion by microorganisms, in addition to various raw materials such as plant-based materials, animal-based materials, and other natural product-based materials, the growth and metabolism of microorganisms are regulated or activated, and special biosynthesis or degradation pathways are induced. In order to achieve this, various compounds can be added to the raw material. For example, as a carbon source, sugar, ethane such as glucose, fructose, galactose, sucrose, maltose, mannose, lactose, glycerin, starch, etc. , Hydrocarbons such as methane, propane, butane, formic acid, acetic acid, propionic acid, lauric acid, palmitic acid, fatty acids such as oleic acid, linoleic acid, linolenic acid, etc., nitrogen sources such as ammonium sulfate, ammonium hydrochloride, ammonium phosphate, etc. Ammonium salts, urea, uric acid, amino acids, etc. Vitamins and compounds containing potassium, calcium, magnesium, sodium, sulfur, phosphorus, chlorine, etc., as well as iron, copper, zinc, cobalt, nickel, boron, manganese, molybdenum, tin, selenium, silicon It is possible to further add compounds contained in the composition such as arsenic, vanadium, chromium and fluorine. In addition, the optimum temperature, oxygen supply amount, pH, pressure, etc. that affect the growth and metabolic activities of various microorganisms can be arbitrarily set according to the characteristics inherent to various microorganisms. Can be arbitrarily set within the range of 10 to 50 ° C., and the pH can be arbitrarily set within the range of 1 to 14.

  In fractionation or purification, generally known techniques can be used as appropriate. In addition to solvent extraction, for example, liquid chromatography (ion exchange chromatography, ion exclusion chromatography, affinity chromatography, gel filtration chromatography, size exclusion chromatography, etc.). Chromatography, hydrophilic adsorption chromatography, hydrophobic adsorption chromatography, ligand exchange chromatography, etc.), dialysis with semipermeable membrane, crystallization and recrystallization of components, filter paper, membrane filter, ultra filter, Examples thereof include filtration using activated carbon, filter aids, etc., centrifugal separation and its application, such as fractional precipitation method, density gradient separation method such as density gradient sedimentation equilibrium method, and the like.

Specific examples of other ingredients other than those described above that are used as additives in cosmetics or quasi drugs containing the agent of the present invention include silicic anhydride, magnesium silicate, talc, kaolin, bentonite, hectorite, natural Or synthetic smectite, stevensite, mica, mica titanium, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, bengara, black iron oxide, gunjo, chromium oxide, hydroxide Inorganic pigments such as chromium, carbon black, calamine, hydrogen peroxide, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate , Sodium pyrophosphate Sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, strontium sulfate, sodium sulfide, barium sulfide , Inorganic reducing agents such as calcium sulfide, redox agents such as thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate), 5- Aminoorcresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, hydrochloric acid 2,4-Diaminophenol, Toluene hydrochloride-2,5- Amine, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diamino Pyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid , Sodium picrate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylene Diamine, metaaminophenol, metaphenylene di Minor, 5-aminoorcresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene sulfate -2,5-diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylene sulfate Diamine, catechol, diphenylamine, α-naphthol, hydroquinone, phloroglucin, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulphonate, dyes such as hematein, musk, civet, cas Natural animal flavors such as thorium and ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, cumin essential oil, black letter essential oil, cinnamon skin Essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western mint essential oil, dairy perfume essential oil, tuberose essential oil, clove essential oil, orange Flower essential oil, winter green essential oil, trubalsum essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, cocoon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot essential oil, peru balsam essential oil, bored rose essential oil, melamine Spirit , Mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, vegetable flavors such as Japanese mint essential oil, other synthetic flavors, 5-amino-o- Cresol, o-aminophenol, m-aminophenol, p-aminophenol, 2,6-diaminopyridine, 5- (2-hydroxylethylamino) -2-methylphenol, N, N-bis (β-hydroxyl)- p-phenylenediamine sulfate, N, N-bis (2-hydroxyethyl) -p-phenylenediamine, p-nitro-o-phenylenediamine, p-phenylenediamine, m-phenylenediamine, N-phenyl-p-phenylene Diamine, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene sodium sulfate, toluene-2,5-diamine, 2- (2'-hydroxyethylamino) -5-aminotoluene, N, N-bis (β-hydride Xyl) -p-phenylenediamine, N, N-bis (2-hydroxyethyl) -p-phenylenediamine sulfate, 5-amino-o-cresol sulfate, p-aminophenol sulfate, o-chloro-p- Phenylenediamine sulfate, 2- (2'-hydroxyethylamino) -5-aminotoluene sulfate, 4,4'-diaminodiphenylamine sulfate, p-methylaminophenol sulfate, p-phenylenediamine sulfate, m- Phenylenediamine sulfate, toluene-2,5-diaminesulfate, 2,4-diaminophenoxyethanol hydrochloride, toluene-2,5-diamine hydrochloride, m-phenylenediamine hydrochloride, 2,4-diaminophenol hydrochloride, 3,3'-iminodiphenol, p-phenylenediamine hydrochloride, N-phenyl-p-phenylenediamine hydrochloride, N-phenyl-p-phenylenediamine acetate, 1,5-dihydroxynaphthalene, toluene-3,4 -Diamine, p- Methylaminophenol, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, o-aminophenol sulfate, 2,4-diaminophenol sulfate, m-aminophenol sulfate Salt, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, nitro-p-phenylenediamine hydrochloride, 1,4-diaminoanthraquinone, nitro-p- Phenylenediamine, picramic acid, sodium picramate, 2-amino-5-nitrophenol sulfate, resorcinol, nitro-p-phenylenediamine sulfate, p-nitro-o-phenylenediamine sulfate, p-nitro-m-phenylene Diamine sulfate, Red No. 2, Red No. 3, Red No. 102, Red No. 104 (1), Red No. 105 (1), Red No. 106, Red No. 201, Red No. 227, Red No. 230 (1 ), Red 230 (2), Red 231, Red 232, Red 401, Red 502, Red 503, Red 504, Red 506, Yellow 4, Yellow 5, Yellow 202 (1), Yellow 202 (2), Yellow 203, Yellow 402 Yellow 403 (1), Yellow 406, Yellow 407, Orange 205, Orange 207, Orange 402, Green 3, Green 204, Green 205, Green 401, Green 402, Brown 201, purple 401, blue 1, blue 2, blue 202, blue 203, blue 205, black 401, red cabbage pigment, red yeast rice pigment, catechol tannin, red rice pigment, red rice pigment, Anato Dye, Ikumi Dye, Turmeric Dye, Enju Dye, Krill Dye, Caramel Dye, Caramel, Gold, Silver, Gardenia Dye, Corn Dye, Onion Dye, Tamarind Dye, Spirulina Dye, Cherry Dye, Nori Dye, Hibiscus Dye, Grape Juice Dye , Grape skin pigment, marigold pigment, purple potato pigment, purple yam pigment, rack color Pigments and colorants such as elemental and rutin, avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber nut oil , Safflower oil, shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil Oils and fats such as molasses, coconut oil, beef tallow, pork fat and hydrogenated products (hardened oil etc.) of these fats, beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, Shellac wax, rice wax, squalene, squalane, pristane and other waxes, liquid paraffin, Mineral oils such as serine, paraffin, ozokelide, ceresin, microcristane wax, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxy Natural fatty acids such as stearic acid, undecylenic acid, tall oil, lanolin fatty acid, etc., synthetic fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid, isopentanoic acid, etc. Fatty acids, ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, natural alcohols such as phenoxyethanol, 2-hexyldecanol, Synthetic alcohols such as sostearyl alcohol and 2-octyldodecanol, isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate Hexyldecyl dimethyloctanoate, diisobutyl adipate, 2-hexyldecyl adipate, diheptylundecyl adipate, N-alkyl glycol monoisostearate, isocetyl isostearate, trimethylolpropane triisostearate, ethylene glycol diethylhexanoate, diethyl Neopentyl glycol hexanoate, cetyl 2-ethylhexanoate, trimethylolpropane triethylhexanoate, tetraethylhexane Esters such as pentaerythritol acid, cetyl octanoate, octyldodecyl gum, cetyl lactate, myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, Metal soaps such as aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate, anionic surfactants (alkyl carboxylates, alkylsulfonates) Alkyl sulfate ester salt, alkyl phosphate ester salt), alkyl sulfate ester salt (sodium lauryl sulfate, potassium lauryl sulfate, lauryl sulfate triethanolate) , Ammonium lauryl sulfate, sodium cetyl sulfate, sodium stearyl sulfate, etc.), secondary alcohol sulfate ester salt, alkyl ether sulfate ester salt (for example, polyoxyethylene lauryl sulfate triethanolamine, polyoxyethylene sodium lauryl sulfate etc.), alkyl and Alkyl allyl ether sulfate ester salt (N-acyl methyl alanine salt, N-acyl glutamate, N-acyl methyl taurate, N-acyl isethionate, N-acyl glycine salt, alkyl phosphate, alkyl ether carboxylate, Alkyl sulfonate, alkyl sulfosuccinate, polyoxyethylene lauryl ether sodium sulfate, polyoxyethylene lauryl ether triethanolamine, polyoxyethylene lauryl ether ammonium sulfate Polyoxyethylene alkyl ether sodium sulfate, polyoxyethylene alkyl ether sulfate triethanolamine, polyoxyethylene alkyl ether sulfate diethanolamine, polyoxyethylene alkyl ether ammonium sulfate, etc.), higher fatty acid alkylolamide sulfate, higher fatty acid ester sulfate Ester salts (hardened coconut oil fatty acid sodium glyceryl sulfate, etc.), polyoxyethylene alkyl ether carboxylic acid, polyoxyethylene alkyl allyl ether carboxylate, sulfated castor oil and other sulfated oils, mono or dialkyl or alkenyl phosphate ester salts Polyoxyethylene mono or dialkyl or alkenyl phosphate esters (sodium monolauryl phosphate, sodium isostearyl phosphate, 2-hexylde Berlin acids arginine, 2-heptyl undecyl phosphorylation
Lithium, polyoxyethylene (4-10) sodium lauryl ether phosphate, sodium monocetyl phosphate, arginine monomyristyl phosphate, sodium monooleyl phosphate, polyoxyethylene (2-10) potassium lauryl ether phosphate, sodium dioctyl phosphate Etc.), phosphoric acid ester salts of polyoxyethylene alkyl ether (polyoxyethylene lauryl ether phosphoric acid, polyoxyethylene oleyl ether phosphoric acid, polyoxyethylene cetyl ether phosphoric acid, polyoxyethylene stearyl ether phosphoric acid, polyoxyethylene alkyl alkyl) Ether phosphate, polyoxyethylene alkylphenyl ether phosphate, etc.), higher fatty acid amide sulfonate or higher fatty acid ester sulfonate (α-olefin sulfonate, N-myristoyl-N- Methyl taurine sodium, coconut oil fatty acid methyl taurine sodium, lauroyl methyl taurine sodium, etc.), alkylbenzene sulfonate (dodecylbenzenesulfonic acid, dodecylbenzenesulfonic acid monoethanolamine, dodecylbenzenesulfonic acid diethanolamine, dodecylbenzenesulfonic acid triethanolamine, Sodium dodecylbenzenesulfonate, etc.), sulfosuccinate (sodium diethylhexylsulfosuccinate, sodium sulfosuccinate, disodium lauryl sulfosuccinate, disodium polyoxyethylene sulfosuccinate, disodium polyoxyethylene sulfosuccinate, polyoxyethylene sulfosuccinate Lauroyl ethanolamide ester disodium, undecylenoylamide ester Disodium tilsulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sodium sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc.), N-acyl sarcosine salts (such as sodium lauroyl sarcosine, palmitoyl sarcosine sodium), condensates of higher fatty acids and amino acids (N-acylglutamate, sodium N-stearoylglutamate, potassium N-palmitoylglutamate, sodium N-lauroyl-L-glutamate, disodium N-stearoyl-L-glutamate, N-myristoyl-sodium L-glutamate, myristoylmethyltaurine Sodium, palmitoylmethyl taurine sodium, stearoyl methyl taurine sodium, N-palmitoyl-β-alanine arginine, N-palmitoy Anionic surfactants such as fatty acid soap such as ditriethanolamine aspartate), oleate, suarenate, laurate, palmitate, etc. (examples of anionic surfactant salts include sodium salt, potassium Alkali metal salts such as salts, monoethanolamine salts, diethanolamine salts, triethanolamine salts, organic ammonium salts such as L-lysine salts and L-arginine salts, ammonium salts, etc.), quaternary ammonium salts (salts) Alkyl trimethyl ammonium, cetyl ammonium chloride, cetyl ammonium bromide, lauryl ammonium chloride, lauryl ammonium bromide, stearyl ammonium chloride, stearyl ammonium bromide, cetyl dimethyl ammonium chloride, cetyl dimethyl ammonium bromide, lauryl dimethyl chloride Ammonium, stearyl dimethyl ammonium chloride, lauryl trimethyl ammonium chloride, lauryl trimethyl ammonium bromide, stearyl dimethyl cetyl ditallow dimethyl ammonium chloride, dicetyl ammonium chloride, dicetyl ammonium bromide, dilauryl ammonium chloride, dilauryl ammonium bromide, chloride Distearylammonium, distearylammonium bromide, dicetylmethylammonium chloride, dicetylmethylammonium bromide, dilaurylmethylammonium chloride, dilaurylmethylammonium bromide, distearylmethylammonium chloride, distearylmethylammonium bromide, chloride Cetyltrimethylammonium, cetyltrimethylammonium bromide, stearyltrimethylammonium chloride, stearic bromide Ryl trimethyl ammonium, lauryl trimethyl ammonium bromide, dialkyl dimethyl ammonium chloride, dicetyl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, dicocoyl dimethyl ammonium chloride, myristyl dimethyl benzyl ammonium chloride, stearyl dimethyl benzyl ammonium chloride, ethyl lanolin sulfate fatty acid amino Propylethyldimethylammonium chloride, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, behenyltrimethylammonium chloride, behenyldimethylhydroxyethylammonium chloride, stearyldimethylbenzylammonium chloride, distearyldimethylammonium chloride, distearoylethylhydroxyethylmonium metasulfate, Cocoylethylhydroxyethylmonium metasulfate, dipalmitoylethylhydroxyethylmonium metasulfate, and cetyltriethylammonium methylsulfate, alkyltrimethylammonium chloride, alkyldimethylbenzylammonium chloride, dialkyldimethylammonium chloride, alkyltrimethylammonium bromide, alkylpentaethoxy chloride Ammonium, ditallow dimethyl ammonium chloride, ditallow dimethyl ammonium methyl sulfate, ditallow dipropyl ammonium phosphate, ditallow dimethyl ammonium nitrate, di (coconut alkyl) dimethyl ammonium chloride, di (coconut alkyl) dimethyl ammonium bromide, coconut ammonium chloride, Stearamidopropyl chloride PG- Monium phosphate, stearamide propyl ethyl dimonium esosulphate, stearamide propyl dimethyl (myristyl acetate) ammonium chloride, stearamide propyl dimethyl cetearyl ammonium tosylate, stearamide propyl dimethyl ammonium chloride, stearamide propyl dimethyl lactic acid Ammonium, ethyl lanolin sulfate fatty acid aminopropylethyldimethylammonium, cationized cellulose, acyldiethylaminoethylamide, acyldimethylaminopropylamide, polyoxyethylene fatty acid amide, myristyldimethylamine oxide, N-lauryldimethylaminoacetic acid betaine, N-myristyldimethyl Aminoacetic acid betaine, N-stearyldimethylaminoacetic acid betaine, etc.), bis-fatty acid ester Salt (hydroxypropyl-bis-lauramidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-myristate amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-palmitamidopropyl-N , N-dimethylammonium chloride, hydroxypropyl-bis-stearic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-behenic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-oleic acid Amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-isostearic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidopropyl-N, N-dimethylammonium chloride Ride, hydroxypropyl-bis-palm fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-tallow fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-lauric acid amidoethyl-N, N -Diethylammonium chloride, hydroxypropyl-bis-myristate amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palmitamidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-stearamide-N, N-diethylammonium chloride, hydroxypropyl-bis-amidoethyl behenate-N, N-diethylammonium chloride, hydroxypropyl-bis-oleamidoethylammonium chloride, hydroxypropyl Pyr-bis-isostearic acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidoethyl-N, N-diethylammonium chloride, Hydroxypropyl-bis-tallow fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-lauramidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-myristate amidopropyl-N, N-diethyl Ammonium chloride, hydroxypropyl-bis-palmitic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-amidopropyl stearate-N, N-diethylammonium chloride, hydroxypropyl Pyr-bis-behenic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-oleic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-isostearic acid amidopropyl-N, N-diethyl Ammonium chloride, hydroxypropyl-bis-coconut fatty acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-tallow fatty acid amidopropyl-N , N-diethylammonium chloride, etc.), stearamidepropyl PG-dimonium chloride phosphate, behenamidopropyl PG dimonium chloride, stearamidepropylethyldimonium ethosulphate, stearamidepropyl dimethyl Cationic surfactants such as ammonium (myristyl acetate) ammonium chloride, stearamidepropyldimethylcetearylammonium tosylate, stearamidepropyldimethylammonium chloride, stearamidepropyldimethylammonium lactate, glycerin fatty acid ester (monoundecylenic acid) Glyceryl, glyceryl diundecylenate, glyceryl monomyristate, glyceryl dimyristate, glyceryl monopalmitate, glyceryl dipalmitate, glyceryl monostearate, glyceryl distearate, glyceryl monooleate, glyceryl monocotton oil fatty acid glycerin, glyceryl monoerucate, Glyceryl sesquioleate, glyceryl monostearate, α, α'-oleic acid pyroglutamate glycerin, monostearic acid (Glyceryl monomyristic acid, diglyceryl dimyristic acid, diglyceryl trimyristate, diglyceryl monopalmitate, diglyceryl dipalmitate, diglyceryl tripalmitate, monostearic acid) Diglyceryl, diglyceryl distearate, diglyceryl tristearate, diglyceryl monooleate, diglyceryl dioleate, diglyceryl trioleate, tetraglyceryl monopalmitate, tetraglyceryl dipalmitate, tetraglyceryl tripalmitate, tetra Tetraglyceryl palmitate, tetraglyceryl pentapalmitate, tetraglyceryl monostearate, tetraglyceryl distearate, tetraglyceryl tristearate Tetraglyceryl tetrastearate, tetraglyceryl pentastearate, tetraglyceryl monooleate, tetraglyceryl dioleate, tetraglyceryl trioleate, tetraglyceryl tetraoleate, tetraglyceryl pentaoleate, hexaglyceryl monopalmitate, dipalmitic acid Hexaglyceryl, hexaglyceryl tripalmitate, hexaglyceryl tetrapalmitate, hexaglyceryl pentapalmitate, hexaglyceryl monostearate, hexaglyceryl distearate, hexaglyceryl tristearate, hexaglyceryl tetrastearate, hexaglyceryl pentastearate, Hexaglyceryl monooleate, hexaglyceryl dioleate, hexaglyceryl trioleate Lil, tetraoleate hexaglyceryl, penta oleic hexaglyceryl monopalmitate decaglyceryl dipalmitate decaglyceryl, DOO
Decaglyceryl Ripalmitate, Decaglyceryl tetrapalmitate, Decaglyceryl pentapalmitate, Decaglyceryl hexapalmitate, Decaglyceryl heptapalmitate, Decaglyceryl octapalmitate, Decaglyceryl nonapalmitate, Decaglyceryl decapalmitate, Monostearin Decaglyceryl acid, decaglyceryl distearate, decaglyceryl tristearate, decaglyceryl tetrastearate, decaglyceryl pentastearate, decaglyceryl hexastearate, decaglyceryl heptearate, decaglyceryl octastearate, decaglyceryl nonastearate , Decaglyceryl decastearate, decaglyceryl monooleate, decaglyceryl dioleate, deoleic acid trioleate Glyceryl, decaglyceryl tetraoleate, decaglyceryl pentaoleate, decaglyceryl hexaoleate, decaglyceryl heptaoleate, decaglyceryl octaoleate, decaglyceryl nonaoleate, decaglyceryl monokaoleate, decaglyceryl monohydroxystearate, dihydroxy Decaglyceryl stearate, dehydroxyglyceryl trihydroxystearate, decaglyceryl tetrahydroxystearate, decaglyceryl pentahydroxystearate, decaglyceryl hexahydroxystearate, decaglyceryl heptahydroxystearate, decaglyceryl octahydroxystearate, nonahydroxystearate Decaglyceryl acid, decahydroxystearate decaglyceryl, poly (Hexaglyceryl synolate, decaglyceryl polyricinoleate, polyoxyethylene glyceryl monostearate, polyoxyethylene glyceryl distearate, polyoxyethylene glyceryl monooleate, polyoxyethylene glyceryl monomyristic acid), polyoxyethylene glycerin fatty acid ester (Polyoxyethylene glycerol monostearate, polyoxyethylene glycerol monoisostearate, polyoxyethylene glycerol triisostearate, etc.), sorbitan fatty acid ester (sorbitan monolaurate, sorbitan monooleate, sorbitan sesquioleate, trioleic acid Sorbitan, sorbitan monopalmitate, sorbitan monostearate, sorbitan distearate, sorbitan dioleate Sorbitan monopalmitate, sorbitan tristearate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate, polyoxyethylene sorbitan monooleate, polyoxymonostearate Ethylene sorbitan, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan trioleate, polyoxyethylene sorbitan pentaoleate, propylene glycol fatty acid ester (propylene glycol monooctanoate, propylene monodecanoate) Glycol, propylene glycol monostearate, etc.), sucrose fatty acid ester (monolauric acid sucrose ester, dilauric acid salt) Sugar ester, monopalmitic acid sucrose ester, dipalmitic acid sucrose ester, monostearic acid sucrose ester, distearic acid sucrose ester, etc.), dextrin fatty acid ester (such as dextrin palmitate), coconut oil fatty acid alkanolamide, polyoxy Ethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, polyoxyethylene Hardened castor oil maleic acid, polyoxyethylene alkyl ether (alkyl polyglucoside, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene base Nyl ether, polyoxyethylene oleyl ether, polyoxyethylene lauryl ether, polyoxyethylene-2-octyldodecyl ether, polyoxyethylene cholestanol ether, etc.), polyoxyethylene alkylphenyl ether (polyoxyethylene nonylphenyl ether, polyoxyethylene) Octylphenyl ether, etc.), polyoxyethylene fatty acid esters (polyethylene glycol monooleate, polyethylene glycol monostearate, polyethylene glycol monolaurate, etc.), lanolin derivatives (polyoxyethylene lanolin, polyoxyethylene lanolin alcohol, polyoxyethylene sorbitol lanolin) Etc.), POE / POP-alkyl ether (POE / POP-cetyl ether, POE / POP-2-decyltetradecyl ether, PO E / POP-monobutyl ether, POE / POP-hydrogenated lanolin, POE / POP-glycerin ether, Tetronic, etc.), alkanolamides (coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.) Ionic surfactants, betaine-type amphoteric surfactants (2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, undecylcarboxymethoxyethylcarboxymethylimidazolinium betaine sodium, Sodium undecylhydroxyethylimidazolinium betaine, undecyl-N-hydroxyethyl-N-carboxymethylimidazolinium betaine, alkyldiaminoethylglycine hydrochloride, stearyl dihydroxyethyl betaine, stearyl Dimethylaminoacetic acid betaine, stearyl dimethylbetaine sodium solution, coconut oil alkyl-N-carboxyethyl-N-hydroxyethylimidazolinium betaine sodium, coconut oil alkylbetaine, coconut oil alkyldimethylaminoacetic acid betaine, coconut oil fatty acid amidopropyl betaine, Palm oil fatty acid-N-carboxymethoxyethyl-N-carboxyethylimidazolinium betaine sodium, N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, N-cocoyl-N'-carboxymethyl-N ' -Hydroxyethylethylenediamine sodium, lauryldimethylaminoacetic acid hydroxysulfobetaine, coconut oil alkyldimethylaminoacetic acid hydroxysulfobetaine, laurylaminopropionic acid triethanolamine, β-lauric Sodium aminopropionate, amidopropyl dimethylaminoacetic acid betaine laurate, amidopropyl dimethylaminoacetic acid hydroxysulfobetaine, coconut oil fatty acid amidopropyldimethylaminoacetic acid hydroxysulfobetaine, palm oil fatty acid amidopropyldimethylaminoacetic acid hydroxysulfobetaine, palm Oil fatty acid amidopropyl dimethylaminoacetic acid betaine, palm oil fatty acid amidopropyldimethylaminoacetic acid betaine, lauryl-N-carboxymethoxyethyl-N-carboxymethylimidazolinium disodium dodecanoyl sarcosine, lauryldiaminoethylglycine sodium, amidopropyl laurate Betaine solution, laurylsulfobetaine, laurylhydroxysulfobetaine, 2-heptadecyl-N-carboxy Methyl-N-hydroxyethylimidazolinium betaine, cocodimethylcarboxymethylbetaine, lauryldimethylcarboxymethylbetaine, lauryldimethylalphacarboxyethylbetaine, cetyldimethylcarboxymethylbetaine, cetyldimethylbetaine, laurylbis- (2-hydroxyethyl) carboxymethyl Betaine, stearylbis- (2-hydroxypropyl) carboxymethylbetaine, oleyldimethylgamma-carboxypropylbetaine, laurylbis- (2-hydroxypropyl) alpha-carboxyethylbetaine, cocodimethylsulfopropylbetaine, stearyldimethylsulfopropylbetaine, lauryl Dimethylsulfoethylbetaine, Laurylbis- (2-hydroxyethyl) sulfopropylbetaine, Levon 2000 ( (Yosei Kasei), palm oil fatty acid amidopropyl dimethyl betaine, coconut oil fatty acid amidopropyl sulfobetaine, imidazolinium type amphoteric surfactant (bis (stearyl-N-hydroxyethylimidazoline) chloroacetic acid complex, N-alkyl-N -Carboxymethyl-N-hydroxyethylimidazolinium betaine, N-alkyl-N-carboxymethyl-N-hydroxyethylethylenediamine lauryl sulfate and its salts, palm oil alkyl-N-carboxyethoxyethyl-N-carboxyethylimidazoli Sodium disodium hydroxide, coconut oil alkyl-N-carboxymethoxyethyl-N-carboxyethyl imidazolinium disodium hydroxide, coconut oil alkyl-N-carboxymethoxyethyl-N-carboxyethyl imidazolinium disodium lauryl sulfate, 2-undecyl- N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, ovazoline 662 (Toho Chemical Co., Ltd.), Swanol AM- 101 (Nikko Chemicals), etc.Aminopropionic acid type amphoteric surfactant (alkylaminopropionic acid such as sodium dodecylaminopropionate, alkylaminodipropionic acid, etc.), sodium dodecylaminopropanesulfonate, N-higher alkylaspartic acid Or salts thereof, coamidopropyl chlorinated polyethylene glycol dimonium phosphate, cocamidopropyl hydroxysultain, sodium lauroyl sarcosinate, alkylamine oxide (decylamine oxide, cocoamine oxide, myristoylamine oxide, palmitoylamine Amphoteric surfactants such as oxide, alkyldimethylamine oxide, alkylamidopropylamine oxide), natural surfactants (lecithin, sodium caseinate, sphingolipid, saponin, mannosyl polyhydric alcohol fatty acid ester, glucosyl polyhydric alcohol fatty acid ester) Monosaccharide polyhydric alcohol fatty acid ester such as galactosyl polyhydric alcohol fatty acid ester or disaccharide polyhydric alcohol fatty acid ester, oligosaccharide polyhydric alcohol fatty acid ester, etc.) and amino acid surfactants (capric acid chloride, lauric acid chloride, myristic) Fatty acid chlorides such as acid chloride, palmitic acid chloride, stearic acid chloride, oleic acid chloride, behenic acid chloride, coconut oil fatty acid chloride and glycine, sarcosine, β-alanine , N-methyl-β-alanine, taurine, N-methyltaurine and other broadly defined amino acids), silicone surfactants (silicon KF-6011 (Shin-Etsu Chemical Co., Ltd.), KF-6012 (Shin-Etsu Chemical) KF-6013 (Shin-Etsu Chemical Co., Ltd.), KF-6016 (Shin-Etsu Chemical Co., Ltd.), KF-6017 (Shin-Etsu Chemical Co., Ltd.), X -22-4991 (manufactured by Shin-Etsu Chemical Co., Ltd.), NUC silicon L7002 (manufactured by Nihon Unicar), SH-3772C (manufactured by Toray Dow Corning Silicone), SH-3775C (manufactured by Toray Dow Corning Silicone), etc. Modified organopolysiloxanes, long chain alkyl-containing polyoxyalkylene modified organopolysiloxanes such as ABIL EM-90 (Gold Schmidt), ABIL B9806 (Gold Schmidt), Silicon KF-6026 (Shin-Etsu Chemical Co., Ltd.) Etc.), polyether-modified silicone (polyoxyethylene / methylpoly (Roxane copolymer, poly (oxyethylene / oxypropylene) methylpolysiloxane copolymer, etc.), oxazoline-modified organopolysiloxane, alkyl-modified organopolysiloxane, styryl ketone silicone derivative, dimethylpolysiloxane, methylphenylpolysiloxane, epoxy-modified Silicone, fluorine-modified silicone, alcohol-modified silicone, alkyl-modified silicone, alkoxy-modified silicone, amino-modified silicone, ammonium-modified polymer silicone, organopolysiloxane, methylphenylpolysiloxane, polysiloxane, poly (N-acylalkyleneimine) -modified silicone , Dimethylpolysiloxane, nitrogen-containing acrylic-silicone graft copolymer, decamethylcyclopentasiloxane, fluorine-substituted al Le-modified silicone, organopolysiloxane siloxanyl silyl alkyl-modified silicone, tricyclic Jiteru Bae Nkarubon acid-modified silicone
, Trifluoroalkyl-modified silicone, divinylpolydimethylsiloxane, dihydrogenpolydimethylsiloxane, dihydrogenpolydimethylsiloxane divinylpolydimethylsiloxane polymer, trimethylsiloxysilicic acid, polyoxypropylene / methylpolysiloxane copolymer, ethylpoly Siloxane, ethylmethylpolysiloxane, ethylphenylpolysiloxane, octamethylcyclotetrasiloxane, diorganopolysiloxane, octamethylcyclotetrasiloxane, tetramethyltetraphenyltetracyclosiloxane, ether-modified polysiloxane, amino-modified polysiloxane, epoxy Modified polysiloxane, fluorine-modified polysiloxane, alcohol-modified polysiloxane, alkyl-modified polysiloxane, dodecame Lucyclohexasiloxane, laurylmethicone copolyol, aminoethylaminopropylsiloxane / dimethylsiloxane copolymer, eugenol-modified silicone and other silicone compounds, selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, hydrochloric acid Examples include hair treatment agents such as quinine and strong ammonia water.

  Others, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, refreshing agents, stabilizers, emulsifiers, animal / plant proteins and their degradation products, animal / plant polysaccharides and their Degradation products, animal / plant glycoproteins and their degradation products, anti-inflammatory agents, antiallergic agents, wound treatment agents, foaming agents, thickeners, enzymes, purified water (electronic water, small clustering, etc.), deodorant / A deodorant etc. can be used in combination.

  Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

[Production Example 1]
100g sorghum (Sorghum bicolor L.) seeds were added as they were to 1.0L of 50% ethanol aqueous solution, soaked and extracted at room temperature for 7 days, then filtered with suction using filter paper, and the residue was removed to extract sorghum 1.0 kg of product was obtained. The solid concentration in the solution of the obtained extract was 0.5%.

[Comparative Example 1]
Agar leaves and branches (1.0 kg) were pulverized, added to 1.0 L of 50% aqueous ethanol solution, soaked and extracted at room temperature for 5 days, and then filtered with suction using filter paper, and the residue was removed to remove Amacha extract 1.0. kg was obtained. The solid concentration in the solution of the obtained extract was 0.7%.

[Example 1]
The hair regeneration rate in the shaved mouse was used as an index of the hair growth inhibiting effect and the hair growth inhibiting effect. Hair removal of about 8 cm ² of the back of C3H mice (8-week-old male C3H mice, 30 animals, reared in an environment of lighting for about 9 hours / day at a room temperature of about 22 ° C. and a humidity of about 50%) with an electric clipper and electric shaver did. Next, Production Example 1 of the present invention on the back from which hair has been removed, Comparative Example 1 which is a component already reported as a hair growth inhibitor, and 100 μL of 50% ethanol aqueous solution as a negative control once a day. Application was performed 5 days a week for 18 days. Judgment is performed on the 11th, 11th, 12th, 13th, 14th, 17th and 18th day after application. Image analysis device (with Victor Color Video Kamera TK-1270, AA-P700 adapter) and analysis software (Mitani Corporation WinRoof) Was used to calculate the area ratio (%) at which hair regeneration was recognized relative to the hair removal area on the back of the mouse (Ogawa et al., Test Method of Fragrance, 1989, 17 (5), 20-29 Reference ). The results are shown in FIG.

[Results of Example 1]
As a result of testing the hair regeneration rate of Production Example 1, Comparative Example 1 and the negative control, the hair regeneration rate of 70.6% for the negative control application and 61.8% for the application of Comparative Example 1 was obtained on the 18th day as the final measurement day. In contrast, the sorghum extract of the present invention (Production Example 1) showed a hair regeneration rate of 33.9%, and even when compared with the conventional hair growth inhibitory component, the hair growth inhibitory effect and hair growth inhibitory effect were excellent. It was found to have In particular, when Comparative Example 1 was applied, a significant increase in hair regeneration rate was observed from the measurement day 17 to 18, while the sorghum extract of the present invention suppressed the increase in hair regeneration rate. Therefore, it was inferred that it is particularly excellent in suppressing hair growth as compared with the conventional one.

(Manufacturing examples of various preparations)
The drug of the present invention and various preparations containing the drug were produced. Although the formulation example is shown below, this invention is not necessarily limited to these.

(Formulation example 1) Hair growth inhibitor (liquid) Weight%
Sorghum seed ethanol extract 10.0
Glycerin 2.0
Fragrance 0.01
Purified water remaining

(Formulation example 2) Hair growth inhibitor (cream) Weight%
Sorghum seed 1,3-butylene glycol extract 15.0
Alkyl polyether modified silicone 2.0
Methylpolysiloxane 5.0
Dimethicone 5.0
Olive oil 5.0
Polyglyceryl diisostearate1.0
Fragrance 0.01
Purified water remaining

(Formulation Example 3) Hair growth inhibitor (milky solution) Weight%
Sorghum seed hot water extract 8.0
Ethanol 10.0
Carboxyvinyl polymer 10.0
Dipropylene glycol 0.5
Liquid paraffin 2.0
Polyoxyethylene oleyl ether 0.3
Octyldodecyl myristate 0.5
Dimethylpolysiloxane 0.3
Fragrance 0.01
Purified water remaining

(Formulation Example 4) After Shave Lotion Weight%
Sorghum seed and leaf aqueous ethanol extract 5.0
Ethanol 50.0
Polyethylene glycol 200 1.0
Polyoxyethylene (60) hydrogenated castor oil 0.2
Monosodium phosphate 0.08
Dipotassium phosphate 0.02
Allantoin 0.04
Dipotassium glycyrrhizinate 0.08
Fragrance 0.01
Purified water remaining

(Formulation example 5) Hair removal cream%
Sorghum seed and stem water extract 5.0
Cetanol 5.0
Liquid paraffin 8.0
Carnauba wax 2.0
Candelilla wax 2.0
Polyoxyethylene (20) stearyl ether 2.0
Polyoxyethylene (20) Polyoxypropylene (20)
Glyceryl ether 3.0
Potassium thioglycolate 0.5
1,3-butylene glycol 5.0
Fragrance 0.01
Purified water remaining

(Formulation Example 6) Body emulsion weight%
Sorghum seed propylene glycol extract 4.0
Polyether-modified organopolysiloxane 5.0
Diglyceryl monostearate 1.5
Decamethylcyclotetrasiloxane 20.0
Dimethylpolysiloxane 10.0
Liquid paraffin 5.0
1,3-butylene glycol 15.0
Sodium chloride 0.2
Fragrance 0.01
Purified water remaining

(Formulation example 7) Cream weight%
Sorghum seed propanol aqueous extract 2.0
Vaseline 8.0
Squalene 20.0
Cetanol 5.0
Glycerol monostearate2.0
Polyoxyethylene (20) sorbitan monolaurate 2.0
Sodium monohydrogen phosphate 1.0
Glycerin 5.0
1,3-butylene glycol 5.0
Dimethylpolysiloxane 3.0
Fragrance 0.01
Purified water remaining

(Prescription Example 8) Lotion weight%
Sorghum seed 1,3-butylene glycol aqueous solution extract 5.0
Sorbitol 2.0
1,3-butylene glycol 4.0
Polyoxyethylene (25) oleyl ether 2.0
Carboxyvinyl polymer 0.2
Ethanol 15.0
Fragrance 0.01
Purified water remaining

(Formulation Example 9) Face wash weight%
Sorghum seed ethanol aqueous extract 1.0
Lauryl phosphate triethanolamine 18.0
Lauric acid triethanolamine 5.0
Glycerin 16.0
Polyoxyethylene sorbitan isostearate 2.0
Cationized cellulose 0.5
Acrylic acid alkyl methacrylate copolymer 0.2
Polyoxyethylene polyoxypropylene block copolymer 0.2
Lauryl hydroxysulfobetaine 5.0
Fragrance 0.01
Purified water remaining

(Formulation Example 10) Body shampoo% by weight
Sorghum seed ethanol aqueous extract 2.0
Myristic acid 3.0
Stearic acid 3.0
Lauric acid 6.0
Polyisoethylene glyceryl monoisostearate0.2
Palm oil fatty acid polyoxyethylene glyceryl 0.2
Methylpolysiloxane 1.5
Polyethylene glycol 6000 0.3
1,3-butylene glycol 10.0
Glycerin 8.0
Potassium hydroxide 5.0
Fragrance 0.01
Purified water remaining

(Formulation example 11) Bath agent (milky solution) Weight%
Sorghum seed hot water extract 5.0
Vaseline 5.0
Succinic acid 0.1
Rice germ oil 1.0
Liquid paraffin 25.0
Polyoxyethylene (5) cetyl phosphate 2.5
Polyoxyethylene sorbit trioleate 1.5
Palm oil fatty acid sorbitan 1.3
Polyoxyethylene (20) glyceryl monooleate 1.0
Glycerin 15.0
Methylparaben 0.01
Fragrance 0.01
Purified water remaining

(Prescription Example 12) Ointment Weight%
Sorghum seed 1,3-butylene glycol aqueous solution extract 10.0
Propylene glycol 8.0
1,3-butylene glycol 5.0
Vaseline 15.0
Carboxyvinyl polymer 5.0
Hydroxyethyl cellulose 8.1
Triethanolamine 2.0
Fragrance 0.01
Purified water 30.0
Remaining amount of ethanol 100

Hair regeneration by application of sorghum extract

Claims (2)

A drug for suppressing hair growth or hair growth, comprising a sorghum extract as an active ingredient. The medicine according to claim 1, wherein the sorghum extract is obtained by extraction using at least one solvent selected from water and lower alcohols.