JP2014114241A - Inhibitor of proopiomelanocortin expression - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a novel and effective inhibitor of proopiomelanocortin expression, or a cosmetic composition and food and drink composition containing an inhibitor of proopiomelanocortin expression.SOLUTION: The cosmetic composition and food and drink composition useful for improvement of skin conditions such as stains, freckles, or dry rough skin contains a certain plant extract (artichoke extract, paeoniae radix extract, loquat leaf extract, lemon balm extract) as active ingredients.

Description

  The present invention relates to a pro-opiomelanocortin expression inhibitor or a pro-opiomelanocortin expression inhibitor for the purpose of suppressing pro-opiomelanocortin (POMC), a protein involved in inflammation produced by ultraviolet rays or stress. The present invention relates to a cosmetic composition and a food / beverage product composition.

  Pro-opiomelanocortin (POMC) is a polypeptide precursor consisting of 241 amino acid residues. From preproopiomelanocortin (pre-POMC), which is a polypeptide precursor having a length of 285 amino acid residues, a signal peptide sequence having a length of 44 amino acid residues is excised by post-translational processing to form proopiomelanocortin. Proopiomelanocortin is mainly produced in the anterior and middle pituitary gland, but it is also produced from skin tissue and the like, and it is also known that the production of proopiomelanocortin is increased by stimulation with ultraviolet rays (non-) Patent Document 1).

Pro-opiomelanocortin has sites that can be cleaved by splicing, and up to 10 active peptides shown below are produced by tissues and converting enzymes. The 10 active peptides include N-terminal peptide proopiomelanocortin (NPP or pro-γ-MSH), γ-melanocyte-stimulating
hormone, γ-MSH), adrenocorticotropic hormone (ACTH), α-melanocyte stimulating hormone (α-melanocyte
stimulating hormone, α-MSH), corticotropin-like intermediate peptide
Peptide, CLIP), β-lipotropin (β-lipotropic hormone, β-LPH), γ-lipotropic (γ-lipotropic)
hormone, γ-LPH), β-melanocyte stimulating hormone (β-MSH), β-Endorphin, methionine-enkephalin.

  Among them, in particular, adrenocorticotropic hormone acts on the outer part of the adrenal gland to control the secretion of corticosteroid hormones. In particular, when stress is applied, the production of adrenocorticotropic hormone increases. The corticotropin is also called corticotropin.

  Further, α-melanocyte stimulating hormone produced by further splicing of adrenocorticotropic hormone is widely known as a hormone that induces melanin production. Although it is a hormone derived from adrenocorticotropic hormone involved in stress response, it is recognized as a melanin-synthesizing hormone induced by ultraviolet rays in general dermatology.

  Thus, it can be said that corticotropin and α-melanocyte stimulating hormone induced by ultraviolet rays and stress are involved in skin aging including pigmentation, but pro-opiomelanocortin, which is the origin of these substances, Inhibiting expression is very important, and is considered to be highly likely to prevent or improve skin aging.

  Based on the above findings, when substances that inhibit the expression of proopiomelanocortin were investigated, panthenol, pyridoxine hydrochloride and nicotinamide were found, but the others were not found (see Patent Document 1).

Aline Primot, Elena Sviderskaya, et al: THE JOURNAL OF BIOLOGICALCHEMISTRY Vol.279, No.49,: pp.51226? 51233,2004

JP2007-176810A

  Then, the subject of this invention is providing the cosmetic composition and food-drinks composition containing a novel and effective proopiomelanocortin expression inhibitor or a proopiomelanocortin expression inhibitor.

  Based on the above findings, the present inventor investigated various plant extracts and repeated diligent studies with natural plants having excellent transdermal absorbability, stability and safety as the theme of development. .

  As a result, the present inventors have found that specific plant extracts (artichoke extract, peony extract, loquat leaf extract, lemon balm extract) have an action of suppressing the expression level of proopiomelanocortin, and Containing a plant extract (artichoke extract, peonies extract, loquat leaf extract, lemon balm extract) as an active ingredient, or a pro-opiomelanocortin expression inhibitor, or a specific plant extract, The present invention has been completed by providing a cosmetic composition and a food / beverage product composition effective for improving skin roughness and the like.

It is a figure which shows the pro-opiomelanocortin expression inhibitory effect of the dokudami extract which made the artichoke extract of this invention, the peony extract, the loquat leaf extract, and the lemon balm extract the pro-opiomelanocortin expression inhibitory effect.

  The “artichoke” used in the present invention is a plant of Compositae, Cynara genus (Cynara): Artichoke (aka: Cynara scolymus), leaves, stems, branches, branches and leaves, Use above ground or whole grass.

In addition, the “peony” used in the present invention is a plant belonging to the family Paeoniaceae and Paeonia: Paeonia.
Lactiflora) roots, rhizomes, flowers are used.

  In addition, as the “biwa” used in the present invention, leaves of Rosaceae and Eriobotrya plants: leaves of Eriobotrya japonica are used.

The “lemon balm” used in the present invention is a plant belonging to the family Lamiaceae, Melissa, and lemon balm (also known as Melus balm) (Melissa).
officinalis) leaves, stems, branches or aerial parts.

  The artichoke extract, peony extract, loquat leaf extract, and lemon balm extract used in the present invention are obtained by extracting various used parts of each plant as they are or after pulverization. Alternatively, it is extracted as it is or after pulverization with a solvent.

  As an extraction solvent for obtaining an extract of each plant used in the present invention, water, lower alcohol such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol or the like, hydrous lower alcohol, propylene glycol, 1,3- Butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,3,5 -Polyhydric alcohol or hydrous polyhydric alcohol such as pentanetriol, glycerin, polyethylene glycol (molecular weight 100 to 100,000), acetone, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, Carbon tetrachloride, phenol, toluene Selected from various organic solvents, acids (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.) prepared as appropriate 1 type, or 2 or more types of mixed liquids are mentioned, It is preferable to select 1 type, or 2 or more types especially chosen from water, ethanol, and 1, 3- butylene glycol. However, if it is not preferable to use a solvent depending on the application, use only water, or perform extraction with a highly volatile solvent that can be easily removed after extraction, and dissolve in water after removing the solvent. Such a method is also possible.

  Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. Although it can set arbitrarily as the temperature of a solvent in the range of -4 degreeC to 100 degreeC, 10-40 degreeC vicinity is preferable from the stability point of the component contained in a raw material. Also, the weight ratio of the solvent to the raw material can be arbitrarily set, for example, in the range of the raw material: solvent 4: 1 to 1: 100, and the weight ratio of 1: 1 to 1:20 is particularly preferable.

  Each plant extract used in the present invention can be further subjected to a refining operation after solvent extraction. The refining operation includes an acid (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, organic acid, etc.) or an alkali ( Decomposition by adding sodium hydroxide, calcium hydroxide, ammonia, etc., fermentation or metabolic conversion by microorganisms, component adsorption by ion exchange resin, activated carbon, diatomaceous earth, etc., various separation modes (ion exchange, hydrophilic adsorption, hydrophobicity) Fractionation using chromatography with adsorption, size exclusion, ligand exchange, affinity, etc.), filtration using filter paper or membrane filter, ultrafiltration membrane, etc., pressurization or decompression, heating or cooling, drying, Examples include pH adjustment, deodorization, decolorization, and long-term storage, and these can be arbitrarily selected and combined.

  In producing the cosmetic composition or food / beverage product composition of the present invention, the shape of the extract of each plant used in the present invention may be any shape such as liquid, solid, powder, and paste. The optimum shape for carrying out the present invention can be arbitrarily selected.

  The content of the extract of each plant used in the present invention in the cosmetic composition or food / beverage composition of the present invention is not particularly limited as long as it can be confirmed that proopiomelanocortin can be suppressed, but is generally not limited. Is set in the range of 0.01 mg / g to 200 mg / g (the denominator indicates the weight of the preparation). Preferably it is the range of 0.1 mg / g-20 mg / g, Most preferably, it is 200 microgram / g-10 mg / g.

  As a cosmetic composition, for example, it can be used in various types of external preparations for skin (including preparations used for animals), specifically, ampoules, capsules, pills, tablets, powders, granules, solids, Appropriate forms for using liquids, gels, bubbles, emulsions, sheets, mists, sprays, etc. 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (eg cosmetics) Basic cosmetics such as water, emulsion, cream, ointment, lotion, oil, pack, facial cleanser and skin cleanser, massage agent, cleansing agent, hair remover, hair remover, shaving treatment, after shave lotion, pre-show Makeup cosmetics such as lotion, shaving cream, foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, beauty nail preparation, beauty nail enamel Beauty nail enamel remover, poultice, plaster, tape, sheet, patch, aerosol, etc.), 4) Medicinal and / or cosmetic preparations applied to scalp and hair (eg shampoo, rinse) Agents, hair treatment agents, pre-hair treatment agents, permanent liquids, hair dyes, hair styling agents, hair styling agents, hair growth / hair restoration agents, poultices, plaster agents, tape agents, sheet agents, patches, aerosol agents, etc.), 5 ) Bathing agents used in bath water, 6) Other anti-smell and deodorants, deodorants, antiperspirants, hygiene products, sanitary cotton, wet tissues, toothpastes, mouth fresheners, gargles, It can also be used as a dishwashing agent.

  As a food / beverage product composition, it is eaten as a health food or a health food, a supplement, or a food material as it is or by adding various nutritional components and adding it to the food / beverage product. For example, after adding the above-mentioned appropriate auxiliaries, it may be used for edible by using conventional means, and forming into an edible form, for example, granular, granular, tablet, capsule, paste, etc. In addition, various foods such as processed marine products such as kamaboko and chikuwa, livestock products such as sausage and ham, Western confectionery, Japanese confectionery, raw noodles, Chinese noodles, boiled noodles, buckwheat noodles, sauce, soy sauce, sauce, Seasonings such as sugar, honey, powdered candy, syrup, etc., spices such as curry powder, mustard powder, pepper powder, jam, marmalade, chocolate spread, pickles, red vegetables, sprinkles, canned and bottled vegetables and fruits Processed vegetables and fruits, dairy products such as cheese, butter, yogurt, miso soup, soup, fruit juice, vegetable juice, whey beverage, soft drink, alcoholic beverages, liquid food, etc. Addition to can be used, also, pet food, can also be used for animals and plants for feed and the like.

  In addition, the pro-opiomelanocortin expression inhibitor of the present invention, the cosmetic composition or the food and drink composition, in addition to each plant extract of the present invention which is an essential active ingredient, a range that does not impair the effects of the present invention Among these, the components and additives exemplified below can be arbitrarily selected and used in combination, and can be added with various functions. The content in the preparation is not particularly limited, but a concentration range of usually 0.0001 to 50% is preferable.

Pigmentation inhibitor A pigmentation inhibitor can be added to the present invention. Specific examples of pigmentation inhibitors include p-aminobenzoic acid derivatives, salicylic acid derivatives, benzenesulfonamide derivatives, imidazole derivatives, naphthalene derivatives, hydroxyanthranilic acid or salts thereof, and derivatives thereof, anthranilic acid derivatives, coumarin derivatives, amino acids Derivatives (2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid, 2-amino-3- [1-carboxyl-2- (1H-imidazole) -4-yl) ethyl] aminobutanoic acid hydrochloride, 2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid sodium salt, 2-amino-3- [ 1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid potassium salt, etc.), benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives Body, camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, ascorbic acid or its salt and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbine) Acid hydroxyproline phosphate,
5-o-α-D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphorus Acid ester calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt , L-ascorbic acid sulfate aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α -D-Galactopyranosyl-L-ascorbic acid, 2-o-β-D-Ga Ctopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6 -o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl-L-ascorbic acid, 6-o-alkyl ascorbic acid phosphate potassium salt, 6-o-alkylascorbic acid phosphate calcium calcium salt, 6-o-alkylascorbic acid phosphate barium salt, 6-o-alkylascorbic acid phosphate ammonium salt, 6-o-alkylascorbic acid phosphate mono Ethanolamine salt, 6-o-alkylascorbic acid phosphate Terdiethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine salt, 6 -o-alkyl ascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate cholesterol ester, Palmitic acid-L-ascorbyl, isopalmitic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid-L -Ascorbyl, diisostearic acid-L-ascorbyl, myristic Acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid-L-ascorbyl, di-2-ethylhexanoic acid- L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D- Maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl -L-ascorbic acid, L-ascorbic acid tetraisopalmitate,
L-ascorbic acid tetralauric acid ester, L-ascorbic acid tetra-2-ethylhexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid trilin Acid ester, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl] -4'-
Acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphoric diester, ascorbic acid inositol-conjugated derivative, ascorbic acid phosphoramide derivative, ascorbic acid arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sial Acid derivatives, etc.), tocopherols or salts thereof and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol , Tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol oro DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-toco Ferryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β- Tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α -Tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L- δ-Tocopheryl maltoside 1- (sulfoethylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol, 1- (carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propane- 2-ol hydrochloride, S- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxy Propyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-iroxy ) -2-Hydroxypropyl] glutamic acid, etc.), tocotrienol or salts thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol Cinnate, tocotrienol linoleate, tocotrienol orotate, etc.), tranexamic acid amide or a salt thereof and derivatives thereof (trans-4-aminomethylcyclohexanecarbonamide, trans-4-aminomethylcyclohexanecarbonamide hydrochloride, Nn-hexyl- Trans-4-aminomethylcyclohexanecarbonamide, Nn-hexyl hydrochloride-trans-4-aminomethylcyclohexanecarbonamide, Nn-heptyl-trans-4-aminomethylcyclohexanecarbonamide, Nn-heptyl hydrochloride Trans-4-aminomethylcyclohexanecarbonamide, Nn-butyl-trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid Nn-butyl-trans-4-aminomethyl Hexanecarbonamide, Nn-propyl-trans-4-aminomethylcyclohexanecarbonamide, N-cyclohexyl-trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N-cyclohexyl-trans-4-aminomethylcyclohexanecarbonamide, N , N-dicyclohexyl-trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N, N-dicyclohexyl-trans-4-aminomethylcyclohexanecarbonamide, N, N-diethyl-trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N , N-diethyl-trans-4-aminomethylcyclohexanecarbonamide, N-benzyl-trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N-benzyl-to 4-aminomethylcyclohexanecarbonamide, N- (4′-methoxyphenyl) -trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N- (4′-methoxyphenyl) -trans-4-aminomethylcyclohexanecarbonamide N- (4′-ethoxyphenyl) -trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N- (4′-ethoxyphenyl) -trans-4-aminomethylcyclohexanecarbonamide, N- (2′-methylphenyl) ) -Trans-4-aminomethylcyclohexanecarbonamide, N- (2'-methylphenyl) -hydrochloric acid hydrochloride, N- (3'-methylphenyl) -trans-4-aminomethylcyclohexane Carvone Amide, N- (3'-methylphenyl) -trans-4-aminomethylcyclohexanecarbonamide, N- (4'-chlorophenyl) -trans-4-aminomethylcyclohexanecarbonamide, N- (4'-chlorophenyl) hydrochloride ) -Trans-4-aminomethylcyclohexanecarbonamide), kojic acid or derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4- ON, 2-Benzolyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H -Pyran-4-one, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid Monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.), oxybenzone, benzophenone, guaiazulene, shikonin, baicalin or salts thereof and derivatives thereof , Baicalein or a salt thereof and derivatives thereof, berberine or a salt thereof and derivatives thereof, chrysin or a salt thereof and derivatives thereof, apigenin or a salt thereof and derivatives thereof, luteolin or a salt thereof and derivatives thereof, acetetine or a salt thereof And derivatives thereof, diosmethine or a salt thereof and derivatives thereof, kaempferol or a salt thereof and derivatives thereof, trifolin or a salt thereof and derivatives thereof, astragaline or Salts thereof and derivatives thereof, quercetin or salts thereof and derivatives thereof, quercitrin or salts thereof and derivatives thereof, isoquercitrin or salts thereof and derivatives thereof, rutin or salts thereof and derivatives thereof, morin or salts thereof And derivatives thereof, myricetin or a salt thereof and derivatives thereof, myricitrin or a salt thereof and derivatives thereof, datiscetin or a salt thereof and derivatives thereof, quercetagetin or a salt thereof and derivatives thereof, isorhamnetin or a salt thereof and derivatives thereof , Pinocembrin or a salt thereof and derivatives thereof, naringenin or a salt thereof and derivatives thereof, hesperetin or a salt thereof and derivatives thereof, eriodictyol or a salt thereof and derivatives thereof, Or a salt thereof and derivatives thereof, aromadendrine or a salt thereof and derivatives thereof, engelitin or a salt thereof and derivatives thereof, taxofolin or a salt thereof and derivatives thereof, astilbine or a salt thereof and derivatives thereof, amperopsin or a salt thereof And derivatives thereof, spiraeoside, kaempferol-7-neohesperidoside, glutathione or salts thereof and derivatives thereof, isoflavone glycosides (6-o-apiosylpuerarin-4'-o-glucoside, 6-o- Glucosyl puerarin, 3'-hydroxy puerarin-4'-o-glucoside, 6-o-apiocil-3'-hydroxy puerarin, etc., γ-pyrone glycoside (maltol-3-o- (6'-o-apiosyl) ) -Glucoside, maltol-3-o- (6'-o-apiosyl) -glucoside, etc.), isononyl ferrate, ellagic acid or its salts And their derivatives (5,4-dimethylellagic acid, 3,3'-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-methoxyellag Acid, 3-ethyl-4-methyl-5-hydroxyellagic acid, amritoside, etc.), lucinol, ondisaponin, bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin, senegin, benzoic acid anilides (4-hydroxy- N- (2-hydroxyphenyl) benzoic acid amide, 4-hydroxy-N- (3-hydroxyphenyl) benzamide, 4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl- 4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N- (3-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4- Hydroxy-N- (2-hydroxyphenyl) benzamide etc. , Diphenylpyralin, cyproheptadine, triprolysine, dimethindene, ozagrel, isothipentyl, iproheptin, homochlorcyclidine, alimemazine, bucillamine, oxytosamide, vidarabine, xanthotoxol, phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, excess Hydrogen oxide water, zinc peroxide, placenta (derived from cattle, pigs, horses, sheep, etc.) extract, almond extract, amaranth extract, Tokyo extract, Japanese apricot extract, Japanese extract, Japanese sweetfish extract , Uncaria extract, Guagecha extract, Gypsophila extract, Licorice extract, Gardenia extract, Kranigean extract, Clara extract, Koganebana (Ogon) extract, Wheat (wheat) extract, Rice (rice) ) Extract, Korea extract, Sidwaya extract, Sankyu extract, Sanvitro extract, Sunpens extract, Silane (Biacyu) extract, Senkyu (river cucumber) extract, Senna extract, Sempukuka extract, Sentsutsusai extract, Surigatin extract, Nodake (Maehu) extract, pearl barley (yokuinin) extract, hamago extract, honey beetle extract, hamamelis extract, palm extract, parietalia extract, safflower (safflower) extract, mugwa (mulberry bark) extract, malvanojadin ( Bitter) extract, purple squirrel extract, white vanilla squirrel extract, mugwort extract, yashajitsu extract, hongkong extract, bitumen extract, quail lily extract, sorghum extract, millipede extract and the like.

Tyrosinase activity inhibitor A tyrosinase activity inhibitor can be added to this invention. Specific examples of tyrosinase activity inhibitors include ascorbic acid or salts thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyprophosphate phosphate ascorbate,
5-o-α-D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphorus Acid ester calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt , L-ascorbic acid sulfate aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α -D-Galactopyranosyl-L-ascorbic acid, 2-o-β-D-Ga Ctopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6 -o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl-L-ascorbic acid, 6-o-alkyl ascorbic acid phosphate potassium salt, 6-o-alkylascorbic acid phosphate calcium calcium salt, 6-o-alkylascorbic acid phosphate barium salt, 6-o-alkylascorbic acid phosphate ammonium salt, 6-o-alkylascorbic acid phosphate mono Ethanolamine salt, 6-o-alkylascorbic acid phosphate Terdiethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine salt, 6 -o-alkyl ascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate cholesterol ester, Palmitic acid-L-ascorbyl, isopalmitic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid-L -Ascorbyl, diisostearic acid-L-ascorbyl, myristic Acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid-L-ascorbyl, di-2-ethylhexanoic acid- L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D- Maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl -L-ascorbic acid, L-ascorbic acid tetraisopalmitate,
L-ascorbic acid tetralauric acid ester, L-ascorbic acid tetra-2-ethylhexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid trilin Acid ester, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxy Ferrate, DL-α-tocopherol-2-L-ascorbic acid phosphate diester, inositol ascorbate binding inducer Body, ascorbic acid phosphoramide derivative, ascorbic acid arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative, etc.), hydroquinone or its salt and derivatives thereof (hydroquinone α-D-glucose, hydroquinone β- Hexasaccharides such as D-glucose, hydroquinone α-L-glucose, hydroquinone β-L-glucose, hydroquinone α-D-galactose, hydroquinone β-D-galactose, hydroquinone α-L-galactose, hydroquinone β-L-galactose Glycosides, hydroquinone α-D-ribose, hydroquinone β-D-ribose, hydroquinone α-L-ribose, hydroquinone β-L-ribose, hydroquinone α-D-arabinose, hydroquinone β-D-arabinose, hydroquinone α-L - Five carbon sugar glycosides such as arabinose and hydroquinone β-L-arabinose, hydroquinone α-D-glucosamine, hydroquinone β-D-glucosamine, hydroquinone α-L-glucosamine, hydroquinone β-L-glucosamine, hydroquinone α-D- Amino sugar glycosides such as galactosamine, hydroquinone β-D-galactosamine, hydroquinone α-L-galactosamine, hydroquinone β-L-galactosamine, hydroquinone α-D-glucuronic acid, hydroquinone β-D-glucuronic acid, hydroquinone α-L -Glucuronic acid, hydroquinone β-L-glucuronic acid, hydroquinone α-D-galacturonic acid, hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, hydroquinone β-L-galacturonic acid and other uronic acid glycosides Hydroquinone glycosides such as hydroquinone benzyl ether 4-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) butane, 5-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) pentane, 6-β- D-glucopyranosyloxy-1- (4-hydroxyphenoxy) hexane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propane, 2-β-D-glucopyranosyl Hydroquinone hydroxyalkyl ether glycosides such as oxy-1- (4-hydroxyphenoxy) butane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propan-3-ol), Koji Acids or salts thereof and derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoyloxymethyl-5- Hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hydroxy-4H- Pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid mono Stearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.), tocopherol or a salt thereof and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate, tokov Roll succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ- Tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β -Tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L- α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ-tocopher Lumaltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, L- (sulfoethylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol, 1- (carboxy Propylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] cysteine, S -[3- (α-Tocopheryl-6-Iroxy) -2-hydroxypropyl] -γ-Glutamylcystenylglycine, N- [3- (α-Tocopheryl-6-Iroxy) -2-hydroxypropyl ] Aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol) , Δ-Tocotrienol, Tocotri Enol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate, etc.), N-acetyltyrosine or its salts and derivatives thereof, glutathione or its salts and derivatives thereof, ellagic acid or its salts and their Derivatives (3,4-dimethylellagic acid, 3,3'-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-methoxyellagic acid, 3 -Ethyl-4-methyl-5-hydroxyellagic acid, amritoside, etc.), isonitrine A, isonitrine B, isonitrine C, isonitrin D, isonitrinic acid E, isonitrinic acid F, dermadein, tricobylidein and other isonitrile antibiotics, orthoric acid Derivatives (orceric acid, orceric acid ethyl ester orcinol, p-geranyl Ruseric acid, p-geranylorceric acid ethyl ester geranylorcinol, p-farnesylorselinic acid, p-farnesylorceric acid ethylester farnesylorcinol, p-dodecanylorceric acid, p-dodecanylorceric acid ethyl Ester dodecanylorcinol, p-tetradecanylorceric acid, p-tetradecanylorceric acid ethyl ester tetradecanylorcinol, p-hexadecanylorceric acid, p-hexadecanylorceric acid ethyl ester Hexadecanylorcinol, p-undecanylorceric acid, p-undecanylorceric acid ethyl ester undecanylorcinol, p-tridecanylorceric acid, p-tridecanylorceric acid ethylester unde Canylorcinol, p-pentadecanylorceric acid, p-pen Tadecanylorceric acid ethyl ester pentadecanylorcinol, ethylhexylorceric acid, p-ethylhexylorceric acid ethylester ethylhexylorcinol, p-cyclohexylmethylorceric acid, p-cyclohexylmethylorceric acid ethylester cyclohexylmethyl Orcinol, p-hydroxyethylhexylorceric acid methyl ester, p-hydroxyethylhexylorceric acid hydroxyethylhexylorcinol, etc.), umbelic acid, brefeldin, oxydesveratrol, resorcinol derivative (4-cyclohexylresorcinol), 3- Hydroxy ketone compounds (1,5-bis (p-hydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (o, p-dihydroxyphenyl) -2-hydroxypentan-4-one, 1, Five -Bis (p-hydroxyphenyl-m-methoxyphenyl) -2-hydroxypentan-4-one, etc.), 1,3-diketone compounds (1,5-bis (p-hydroxyphenyl) -2,4-pentanedione 1,5-bis (o, p-dihydroxyphenyl) -2,4-pentanedione, 1,5-bis (p-hydroxyphenyl-m-methoxyphenyl) -2,4-pentanedione, etc.), bishydroxy Benzylamides, γ-aminobutyric acid or its derivatives (N-methyl-γ-aminobutyric acid, N-dimethyl-γ-aminobutyric acid, γ-aminobutyric acid oleyl ester, etc.), hydrogen peroxide, zinc peroxide, placenta extract, Lucinol, Silk extract, Acacia extract, Acerola extract, Ichibi (winter position) extract, Inularacemossa extract, Weeping birch extract, Quercus extract, Chestnut extract, Kamebahikokoshi extract, Cloveranakikoshi extract, Sensi Wren extract, Seri extract, Buckwheat extract, Davilia extract, Nazuna extract, Fujiba kama (Orchid grass) extract, Chamomile extract, Mulberry extract, Gardenia extract, Japanese crested extract, Walnut extract, Clara extract, Mugwort extract, Honeysuckle extract, Yellowfin extract, Dokudami Extracts Extract, Mao Extract, Senkyu Extract, Dokatsu Extract, Psycho Extract, Bow Fu Extract, Hamabou Fu Extract, Ogon Extract, Peony Skin Extract, Genno Shoko Extract, Root extract, licorice extract, gallnut extract, aloe extract, Cimicifuga extract, safflower extract, green tea extract, black tea extract, include Abe elixir extract, and the like.

Melanocyte Melanin Production Inhibitor A melanocyte melanin production inhibitor can be added to the present invention. Specific examples of melanocyte melanin production inhibitors include lobeline or lobeline derivatives, liquiritin derivatives (such as liquiritin-α-glucoside, liquiritin-α-maltoside), phenylchroman derivatives, chromone derivatives (2-butylchromone, 2-pentylchromone, 2 -Heptylchromone, 2-nonylchromone, 2-hexadecylchromone, 2- (1-ethylpentyl) chromone, 2-butyl-7-methoxychromone, 2-pentyl-7-methoxychromone, 2-heptyl-7-methoxychromone , 2-nonyl-7-methoxychromone, 2-pentadecyl-7-methoxychromone, 2- (1-ethylpentyl) -7-methoxychromone, 7-hydroxy-2-methylchromone, 7-hydroxy-2-butylchromone 7-hydroxy-2-pentylchromone, 7-hydroxy-2-heptylchromone, 7-hydroxy-2-nonylchromone, 7-hydroxy -2-pentadecylchromone, 7-hydroxy-2- (1-ethylpentyl) chromone), azelaic acid derivatives (eg azelaic acid monoalkyl ester, azelaic acid dialkyl ester), phosphatidylglucosamine, lysophosphatidylglucosamine, phenylhydroquinone, 3-β-D-glucopyranosyl manur, 3-β-D-maltopyranosyl manur, substituted amino acid derivatives (DL-N-formyl-3- (1-naphthyl) alanine, DL-N-acetyl-3 -(1-naphthyl) alanine, DL-N-propionyl-3- (1-naphthyl) alanine, DL-N-butyryl-3- (1-naphthyl) alanine, DL-N-isobutyryl-3- (1-naphthyl) ) Alanine, DL-N-valeryl-3- (1-naphthyl) alanine, DL-N-isovaleryl-3- (1-naphthyl) alanine, DL-N- (2-methylvaleryl) -3- (1-naphthyl) Alanine, DL-N- (3-Methylvaleryl) -3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine, DL-N-t-butylacetyl-3- (1-naphthyl) alanine, DL-N-pivaloyl- 3- (1-naphthyl) alanine, DL-N-caproyl-3- (1-naphthyl) alanine, DL-N- (2-ethylhexanoyl) -3- (1-naphthyl) alanine, DL-N- ( 2-methylhexanoyl) -3- (1-naphthyl) alanine, DL-N-heptanoyl-3- (1-naphthyl) alanine, DL-N-octanoyl-3- (1-naphthyl) alanine, DL-N- (2-propylpentanoyl) -3- (1-naphthyl) alanine, DL-N-nonanoyl-3- (1-naphthyl) alanine, DL-N-decanoyl-3- (1-naphthyl) alanine, DL-N -Undecanoyl-3- (1-naphthyl) alanine, DL-N-dodecanoyl-3- (1-naphthyl) alanine, DL-N-tridecanoyl-3- (1-naphthyl) alanine, DL-N-tetradecanoyl- 3- (1-Naph ) Alanine, DL-N-pentadecanoyl-3- (1-naphthyl) alanine, DL-N-hexadecanoyl-3- (1-naphthyl) alanine, DL-N-heptadecanoyl-3- (1-naphthyl) ) Alanine, DL-N-octadecanoyl-3- (1-naphthyl) alanine, DL-N-nonadecanoyl-DL-3- (1-naphthyl) alanine, DL-N-icosanoyl-3- (1-naphthyl) Alanine, DL-N-Acroyl-3- (1-naphthyl) alanine, DL-N-crotoniloyl-3- (1-naphthyl) alanine, DL-N-methacryloyl-3- (1-naphthyl) alanine, DL-N -Vinylacetyl-3- (1-naphthyl) alanine, DL-N-cyclopropanoyl-3- (1-naphthyl) alanine, DL-N- (2-pentenoyl) -3- (1-naphthyl) alanine, DL -N- (4-pentenoyl) -3- (1-naphthyl) alanine, DL-N- (2-hexenoyl) -3- (1-naphthyl) alanine, DL-N- (3-hexenoyl) -3- ( 1-naphthyl) Lanin, DL-N- (2-Methyl-3-pentenoyl) -3- (1-naphthyl) alanine, DL-N-cyclohexenoyl-3- (1-naphthyl) alanine, DL-N- (10 -Undecenoyl) -3- (1-naphthyl) alanine, DL-N-linoleyl-3- (1-naphthyl) alanine, DL-N-hydroxyacetyl-3- (1-naphthyl) alanine, DL-N- (6 -Hydroxycaproyl) -3- (1-naphthyl) alanine, DL-N- (8-hydroxyoctanoyl) -3- (1-naphthyl) alanine, DL-N- (9-hydroxynonanoyl) -3- (1-naphthyl) alanine, DL-N- (10-hydroxydecanoyl) -3- (1-naphthyl) alanine, DL-N- (11-hydroxyundecanoyl) -3- (1-naphthyl) alanine, DL-N- (12-hydroxydecanoyl) -3- (1-naphthyl) alanine, DL-N-benzoyl-3- (1-naphthyl) alanine, DL-N- (2-hydroxybenzoyl) -3- ( 1-naphthyl) arani DL-N- (3-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (4-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (o-toluyl) ) -3- (1-naphthyl) alanine, DL-N- (m-toluyl) -3- (1-naphthyl) alanine, DL-N- (p-toluyl) -3- (1-naphthyl) alanine, DL -N- (1-naphthoyl) -3- (1-naphthyl) alanine, DL-N- (2-naphthoyl) -3- (1-naphthyl) alanine, DL-N- (2-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (4-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N -(2-Picoloroyl) -3- (1-naphthyl) alanine, DL-N- (3-Picoloroyl) -3- (1-naphthyl) alanine, DL-N- (4-Picoloroyl) -3- (1- Naphthyl) alanine, DL-N-phenylacetyl-3- (1-naphthyl) arani DL-N- (2-phenylpropanoyl) -3- (1-naphthyl) alanine, DL-N- (3-phenylbutyryl) -3- (1-naphthyl) alanine, DL-N- (4 -Methylvaleryl) -3- (1-naphthyl) alanine, DL-N-valeryl-3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanineamide, DL- N- (4-methylvaleryl) -3- (1-naphthyl) alanine methyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine ethyl ester, DL-N- (4-methylvaleryl)- 3- (1-naphthyl) alanine propyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine-N-butyl ester, DL-N- (4-methylvaleryl) -3- (1- Naphthyl) alanine pentyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine isopropyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) ) Alanine isobutyl ester, DL-N-(4-methylvaleryl) -3- (1-naphthyl) alanine -t- butyl ester, etc.), benzo lactam derivatives, Indolactam derivatives, cedrol, guaiol,
1- (4-hydroxyphenthio) -2-propanol, β-lactoglobulin, 2-methoxy-5-methylphenol, 5-ethyl-2-methoxyphenol, 5-N-propyl-2-methoxyphenol, 5- N-butyl-2-methoxyphenol, 5-N-hexyl-2-methoxyphenol, 5-N-heptyl-2-methoxyphenol, 5-N-decyl-2-methoxyphenol, 5- (1,1-dimethyl) Propyl) -2-methoxyphenol, 5- (1,1-dimethylbutyl) -2-methoxyphenol, 5- (1,1-dimethylethyl) -2-methoxyphenol, 2-methoxy-5- (1-methyl) Pentyl) phenol, 2-methoxy-5- (1-methylhexyl) phenol, 2-methoxy-5- (3-methylhexyl) phenol, 2-methoxy-5- (6-methylheptyl) phenol, 5- (1 , 3-Dimethylheptyl) -2-methoxyphenol, malberine, ferruginol, sugi , Cryptojaponol, 1,5-bis [p-hydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [o-hydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [2,4-dihydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [3-methoxy-4-hydroxyphenyl] -1,4-pentadien-3-one , Haginin, agrimophor, agrimol, hydrangenol or derivatives thereof, alkylresorcinol or derivatives thereof (such as 4-N-butylresorcinol), aristrone, caramenenes (caramenene, 7-hydroxycaramenene, 5-hydroxycaramenen 7-methoxycaramenene, etc.), trans-umberic acid, N-α-benzoyl-L-arginine, N-α-benzoyl-L-arginine ethyl ester or N-α-benzoyl-L-arginine ethyl ester, 5-methyl -2 (3H) -furanone, 2-butene -4-Orido, 2-hydroxymethylfuran, 2,5-dimethyl-4-hydroxy-3 (2H) -furanone, 2-formylfuran, 3-formylfuran, methyl α-furyl ketone, furfuryl acetate, 2-hydroxy -3-methyl-2-cyclopenten-1-one, 2-hydroxy-3,5-dimethyl-2-cyclopenten-1-one, 2,5-dimethyl-4-hydroxy-3 (2H) -thiophenone, 2- Hydroxy-3-ethyl-2-cyclopenten-1-one, tetronic acid, pentanedione, iminodibenzyls (2,2'-iminodibenzyl, imipramine, imipramine hydrochloride, desipramine, desipramine hydrochloride, chlorimipramine, trimipramine, etc. ), Dibenzocycloheptadiene (amitriptyline, amitriptyline hydrochloride, nortriptyline, noxypetitin, etc.), tetrahydrocopalol glycoside (ketotifen fumarate) , Rabda-8 (17), 13-dien-15-ol, tetrahydromanur, tetrahydrocoparol, tetrahydrocoparol glucoside, tetrahydrocoparol galactoside, tetrahydrocoparol maltoside, tetrahydrocoparol cellobioside, tetrahydrocoparol Maltotrioside, etc.), spiro ether compound, piochelin, phenothiazine compound, promethazine, alimemazine, alimemazine tartrate, triflupromazine, levomepromazine, chlorpromazine, cyclandrate, 4-carboxymethyloxybenzoic acid, 4-carboxymethyloxy-2- Hydroxybenzoic acid, 3- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) benzoic acid, 4- (3-carboxypropyl-1-oxy) -2-Hydroxy repose Acid, 4- (3-carboxypropyl-1-oxy) -2-methoxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1- Oxy) -2-hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid, 4- ( 10-carbamoyldecane-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) benzoic acid, 4- (4-hydroxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-acetoxybutyl-1-oxy) benzoic acid, 4- (4-acetoxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-ethoxycarbonylpropyl-1-oxy) -2- Hydroxybenzoic acid, 3- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-methoxybutyl-1-oxy) 2-hydroxybenzoic acid, 4- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3- (3-carboxypropyl-1- Oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 6- ( 3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) -2- Hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid, hydroxytrimethylcyclohexanes (2-hydroxy-4- (2,2,6-trimethyl-1-yl-cyclohexane) butane 4- (2,2,6-trimethyl-1-yl-cyclohexane) -1-butene, 4- (2,2,6-to Methyl-1-yl-cyclohexane) -2-butene, 4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 3-methyl-3-hydroxy-5- (2,2,6-trimethyl) -1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-5- (2,2,6-trimethyl) -1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -3-pentene, 3-methyl-3-hydroxy-5- ( 2,2,6-trimethyl-1-yl-cyclohexane) -1-pentene, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -2-pentene, 2 -Hydroxy-4- (2,2,6-trimethyl-1-yl-cyclohexane) butane and other monosaccharides, disaccharides or trisaccharide glycosides), escinol, parahydroxycinnamic acid-4- (2,2 , 6-Trimethyl-yl-shi Rohexane) -2-butyl ester monosaccharide, disaccharide or trisaccharide glycoside, ondisaponin, bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin, senegin, 4- (2,2,6-trimethyl- 1-yl-cyclohexane) -2-keto-butane, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto-butane, 4- (2,2,6-trimethyl- 1-yl-cyclohexane) -2-keto-3-butene, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto-3-butene (β-ionone), Lp- Hydroxyphenylglycine, Dp-hydroxyphenylglycine, N-benzyloxycarbonyl-Lp-hydroxyphenylglycine, N-benzyloxycarbonyl-Dp-hydroxyphenylglycine, N-benzoyl-Lp-hydroxyphenylglycine, N-benzoyl-Dp- Hydroxyphenylglycine, N- (p-methoxy Benzoyl) -Lp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Dp-hydroxyphenylglycine, N- (p-hydroxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-hydroxybenzoyl) -Dp- Hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine, N-acetyl-Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine ethyl ester, N-acetyl-Dp-hydroxyphenylglycine ethyl ester, N- Acetyl-Lp-hydroxyphenylglycinamide, N-acetyl-Dp-hydroxyphenylglycinamide, Lp-methoxyphenylglycine, Dp-methoxyphenylglycine, Lp-methoxyphenylglycine hydrochloride, Dp-methoxyphenylglycine hydrochloride, 4- Hydroxy-3-methoxy-L-phenylglycine, 4-hydro Ci-3-methoxy-D-phenylglycine, Lp-hydroxyphenylglycine ethylamide, Dp-hydroxyphenylglycine ethylamide, N-tert-butoxycarbonyl-Lp-hydroxyphenylglycine, N-tert-butoxycarbonyl-Dp-hydroxy Phenylglycine, N-tert-butoxycarbonyl-Lp-methoxyphenylglycine, N-tert-butoxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxyphenylglycine, N-9- Fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxyphenylglycine benzyl ester hydrochloride, N-9-fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine Benzyl ester hydrochloride, Lp-hydroxyphenylglycine amino acid , Dp-hydroxyphenylglycine amide, Lp-hydroxyphenylglycine allyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine allyl ester p-toluenesulfonate, Lp-hydroxyphenylglycine benzyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine benzyl ester p-toluenesulfonate, Lp-hydroxyphenylglycine ethyl ester, Dp-hydroxyphenylglycine ethyl ester, Lp-hydroxyphenylglycine ethyl ester hydrochloride, Dp-hydroxyphenylglycine ethyl ester hydrochloride, Lp-hydroxyphenylglycine methyl ester, Dp-hydroxyphenylglycine methyl ester, etc., 1,3-diallylindane-2-carboxylic acids, stachybosines, pheophorbide derivatives, eleucelli , Isoeleucerine or 4-β-hydroxyisoereucerine, eleucerinol, spiroketal derivatives (2- (2,4-hexadinylidene) -1,6-dioxaspiro [4.5] dec-3-ene, 2- (2 -Hexynylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-((4-methylphenyl) methylidene) -6,6-dioxaspiro [4.4] non-3-ene, 2- (2-hexenylidene ) -6,6-Dioxaspiro [4.5] dec-3-ene, 2- (2-hexenylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-hexyl-1,6-dioxaspiro [4.4] Nonane, 2- (2-hexenyl) -1,6-dioxaspiro [4.4] nonane, 2- (2-hexynyl) -1,6-dioxaspiro [4.4] nonane, 2-pentyl-1,6-dioxaspiro [4.4] Nonane, 1,6-dioxaspiro [4.4] nonane, 1,6-dioxaspiro [4.5] decane, 1,7-dioxaspiro [5.5] undecane, 2,3-benzo-4,4-dimethyl-1,6-dioxy Spiro [4.4] nonane, 3,4-benzo-2-pentyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-hexyl-1,6-dioxaspiro [4.4] nonane, 3,4- Benzo-2-octyl-1,6-dioxaspiro [4.4] nonane, 2-hexyl-9,9-dimethyl-1,6-dioxaspiro [4.4] nonane, 2- (2,4-hexadinylidene) -1, 6-dioxaspiro [4.4] non-3-ene etc.), malvalic acid, phosphonic acid derivative or salt thereof, aspergillomarasmine, aminophosphonic acid derivative or salt thereof, diphenhydramine or salt thereof, pregnenolone or derivative thereof, lutein, farnesyl Isopropanol derivatives, hexahydrofarnesyl acetone, 4-benzoylamino-2-hydroxybenzoic acid, 5-benzoylamino-2-hydroxybenzoic acid, 4-benzoylaminobenzoic acid, 4- (1-naphthoylamino) -2-hydroxy Benzoic acid, 5- (1 -Naphthoylamino) -2-hydroxybenzoic acid, 4- (2-naphthoylamino) -2-hydroxybenzoic acid, 5- (2-naphthoylamino) -2-hydroxybenzoic acid, 4- (1-naphtho Ylamino) benzoic acid, 4- (2-naphthoylamino) benzoic acid, 4-phenylaminocarbonylbenzoic acid, 4-phenylaminocarbonyl-2-hydroxybenzoic acid, 5-phenylaminocarbonyl-2-hydroxybenzoic acid, 4- (1-naphthylaminocarbonyl) benzoic acid, 4- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 4- (2-naphthyl) Aminocarbonyl) benzoic acid, 4- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, hexahydrofarnesyl isopropanol derivative, Renole-p-hydroxycinnamic acid ester glucoside, Borneol-p-hydroxycinnamic acid maltoside, Borneol-p-hydroxycinnamic acid maltotrioside, Cinnamic acid-4- (2,2,6-trimethyl- Yl-cyclohexane) -2-butyl ester derivatives, 2,4-dihydroxybenzophenone, 1- (2,4-dihydroxyphenyl) -ethanone (2 ', 4'-dihydroxyacetophenone), 1- (2,4-dihydroxyphenyl) ) -1-propanone (2 ', 4'-dihydroxypropiophenone), 1- (2,4-dihydroxyphenyl) -1-butanone, 1- (2,4-dihydroxyphenyl) -1-pentanone, 1- (2,4-dihydroxyphenyl) -1-hexanone, 1- (2,4-dihydroxyphenyl) -1-heptanone, 1- (2,4-dihydroxyphenyl) -1-octanone, 1- (2,4- Dihydroxyphenyl) -1-nonanone, 1- (2,4- Hydroxyphenyl) -1-decanone, 1- (2,4-dihydroxyphenyl) -1-undecanone, 1- (2,4-dihydroxyphenyl) -1-dodecanone, 1- (2,4-dihydroxyphenyl) -1 -Tetradecanone, 1- (2,4-dihydroxyphenyl) -1-hexadecanone, 1- (2,4-dihydroxyphenyl) -1-octadecanone, 1- (2-hydroxy-4-methoxyphenyl) -ethanone (2 '-Hydroxy-4'-methoxyacetophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-propanone (2'-hydroxy-4'-methoxypropiophenone), 1- (2-hydroxy-4- Methoxyphenyl) -1-butanone, 1- (2-hydroxy-4-methoxyphenyl) -1-pentanone, 1- (2-hydroxy-4-methoxyphenyl) -1-hexanone, 1- (2-hydroxy-4 -Methoxyphenyl) -1-heptanone, 1- (2-hydroxy-4-methoxyphenyl) -1-one Thanone, 1- (2-hydroxy-4-methoxyphenyl) -1-nonanone, 1- (2-hydroxy-4-methoxyphenyl) -1-decanone, 1- (2-hydroxy-4-methoxyphenyl) -1 -Undecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-dodecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-tetradecanone, 1- (2-hydroxy-4-methoxyphenyl)- 1-hexadecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octadecanone, 1- (4-hydroxy-2-methoxyphenyl) -ethanone (4'-hydroxy-2'-methoxyacetophenone), 1- (4-hydroxy-2-methoxyphenyl) -1-propanone (4'-hydroxy-2'-methoxypropiophenone), 1- (2,4-dimethoxyphenyl) -ethanone (2 ', 4'-dimethoxyacetophenone) ), 1- (2,4-Dimethoxyphenyl) -1-propanone (2 ', 4'-dimethoxypropi Phenone), lactone derivatives (1,6-dioxaspiro [4.4] nonane-2,7-dione, 1,6-dioxaspiro [4.5] decane-2,7-dione, 4-tridecanolide, 4-dodecanolide, 4-undecanolide, 4-decanolide, 4-nonanolide, 4-octanolide, 4-heptanolide, 5-dodecanolide, 5-undecanolide, 5-decanolide, 5-nonanolide, 5-octanolide, 2-undecen-4-olide, 2-decen-4- Orido, 2-Nonene-4-Olide, 2-Heptene-4-Olide, 2-Undecen-5-Olide, 2-Decene-5-Olide, 2-Nonene-5-Olide, 2-Octene-5-Olide, 4-methyl-4-dodecanolide, 4-methyl-4-undecanolide, 4-methyl-4-decanolide, 4-methyl-4-nonanolide, 4-methyl-4-heptanolide, 5-methyl-5-dodecanolide, 5- Methyl-5-undecanolide, 5-methyl-5-decanolide, 5-methyl-5-nonanolide, 5-methyl-5-octanolide, 2- Methoxycarbonyl-4-dodecanolide, 2-methoxycarbonyl-4-undecanolide, 2-methoxycarbonyl-4-decanolide, 2-methoxycarbonyl-4-nonanolide, 2-methoxycarbonyl-4-heptanolide, 2-methoxycarbonyl-5- Undecanolide, 2-methoxycarbonyl-5-decanolide, 2-methoxycarbonyl-5-nonanolide, 2-methoxycarbonyl-5-octanolide, 2-allyl-4-undecanolide, 2-allyl-5-decanolide, 2-allyl-4 -Nonanolide, 2-pentyl-4-undecanolide, 2-pentyl-4-nonanolide, 2-methyl-4-undecanolide, 2-methyl-4-nonanolide, 2- (4-hydroxybutyl) -4-undecanolide, 2- (4-hydroxybutyl) -4-nonanolide, 2- (4-hydroxybutyl) -5-decanolide, 5-propyloxy-4-pentanolide, 5-allyloxy-4-pentanolide, 5- (2-hydroxyl Ethoxy) -4-pentanolide, 8-hydroxy-4-octanolide, 6-propyloxy-5-hexanolide, 6-allyloxy-5-hexanolide, 6- (2-hydroxyethoxy) -5-hexanolide, 9-hydroxy-5 -Nonanolide etc.), ethinomycin, iriflorental, iriparidal, 2'-8-C-glucosyl-7-methylaloesol coumaroyl ester, 2'-8-C-glucosyl-7-methylaloesol cinnamoyl ester, Chloropyramine, anise extract, aloe extract, itadori (tiger cane root) extract, sea squirrel extract, shrimp moth extract, ketsumeishi (Keiko) extract, ogi (yellow cocoon) extract, yellow eagle extract, red-crowned cucumber (calocon) extract, onamomi ) Extract, Oninoyara extract (Tempa) extract, Oyster extract, Greater redbird extract, Oyaku extract, Cabo Extract, Gama extract, Kansui extract, Crimson extract (Cryptomeria japonica) extract, Chromoji extract, Black spider extract, Sisal (Sisal) extract, Saximara button extract, Cinnamon stick extract, Cinnabo ) Extract, Oshima cherry extract, Oya cherry extract, Bean cherry extract, Takane cherry extract, Kohigan extract, Sato cherry extract, Zion (purple camellia) extract, Chloro extract, White vanilla extract, Ginseng extract, Tamshiba (hot pepper) extract, Daimonjisou Extract, primrose extract, toshishi extract, legume extract, pear extract, sagebrush extract, yarrow extract, hakusen (white ringworm) extract, dill extract, honey beetle extract, starfish Kiss, Hitotsuba (stone persimmon) extract, Himegama (koi) extract, Japanese peony extract, Floral blanca extract, Hamura extract, Scallop extract, Convolvulaceae extract, Sandalwood extract, Ganoderma biloba extract, Swordfish (benuse grass) extract, River willow extract , Red willow extract, pussy willow extract, dog collage willow extract, quince willow extract, corry willow extract, unryu willow extract, miya willow extract, willow willow extract, corn willow extract, tiger lily Extract, agave extract, blue agave extract, fuchlin agave extract, mitsumata extract, aonori extract, usba aonori extract, suea aonori extract, hi Raaonori Extract, Bowuaonori Extract, Hosoeda Aonori Extract, Kombu Extract, Macombu Extract, Risilibubu Extract, Hosome Kombu Extract, Mitsuishi Kombu Extract, Wakame Extract, Hirome Extract, Aowakame Extract, Hijiki Extract, Hibamata Extract, Umichiwa Extract, Usubamichiwa Extract Kirebano Miuchiwa Extract, Akaba Miuchiwa Extract, Kona Miuchiwa Extract, Okinawa Chiwa Extract, Usuki Uchiwa Extract, Etsumi Miuchiwa Extract, Togekirinsai Extract, Amakusa Rhinoceros Extract, Giraffe Rhinoceros Extract, Ginseng Rhinoceros Extract, Tsunomata Extract Tsunomata extract, hirakotoji extract, sugi nori extract, shikinori extract, kainori extract, yakuzusa extract, uraboshiya hazuki , Umichiwa extract, Ishimo-Zuku extract, Misjikonbu extract, Atsumi-Mizumbu extract, Isomoku extract, Nagashima-moku extract, Shida-moku extract, Nejimoku extract, Narasamo extract, Mametawala extract, Japanese chestnut extract, Yatsuma-Tamoku extract, Umi-Tranoku extract, Japanese red-bellied extract Extract Jungle extract, Kurosozo extract, Kobosozo extract, Hanesozo extract, Sozonohana extract, Haezaki Sawtooth extract, Thira extract, Mode Tede bruises franc extract, Hamaikaekisu, port Leo Verde extract, Nabo Negro extract, Schisandra chinensis extract, Matsubusa extract, Binankazura extract, and the like.

Melanin production promoter A melanin production promoter can be added to the present invention. Specific examples of the melanin production promoter include salicylic acid or a salt thereof and derivatives thereof (salicylic acid glucoside, salicylic acid fatty acid ester, salicylic acid alcohol ether, salicylic acid amides, etc.), salicyl alcohol or a salt thereof and derivatives thereof, apigenin, and amentoflavone. , Salamander Extract, Udo Extract, Shishido Extract, Nilin Sou Extract, Oak Extract, Beef Taxi Extract, Cuckoo Thistle Extract, Gypsophila Extract, Gymnema Sylvestre Extract, Karo Oyster Extract, Ginkgo Kinca Extract, Konronka Extract, Sabin Ryo Extract, Jasmine (pine licorice) extract, hollyhock extract, scallop extract, Arabidopsis extract, lily of the valley extract, sawnose extract, deco extract, tochu , Nagii Kada (Butcher Bloom) extract, Teppo cucumber extract, Tokiwa Mansaku extract, Nankin goat extract, Elderflower extract, Nadeshiko extract, Michiyanagi extract, Japanese willow extract, Morohaya extract Tamazaki wisteria extract, Ryokaou extract, Amijigusa extract, shellfish extract (cockle extract, green mussel extract, oyster extract, European oyster extract, scallop extract, clam extract, clam extract, bakagai extract, isoyster mussel extract, red oyster extract, abalone extract , Sazae extract, bi-extract, etc.).

Humectant A humectant can be added to the present invention. Specific examples of moisturizers include gum arabic, benzoin rubber, danmar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum, carob gum, quince seed, agar or its derivatives, casein, glucose, galactose, mannose, xylose, fructose, maltose, iso Maltose, cellobiose, gentiobiose, trehalose, cordierbiose, laminaribiose, nigerose, sambubiose, neohesperidose, apiose, hammamellose, streptose, hydroxystreptose, dihydrostreptose, 2-methylerythrose or derivatives thereof, 2-methylerythrono Lactone, micalose, cladinose, accessose, alkanose, olivomai course, chromose, ebamise, vinerose , Sugars such as nogarose, bilenose, nobiose, moenuronic acid, galosamine, cybirosamine, N-acylcansosamine, vancosamine, evanitrose, rubranitrose, tetronitrose, pyralose, α-octose, trioxacalcinose, aldgarose, blastminosin 1,3-butylene glycol, glycerin, propylene glycol, polyethylene glycol, dipropylene glycol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,6-hexanediol, mannitol and Sorbitol, ethanediol, diethylene glycol, triethylene glycol, 2-amino-2-methyl-1,3-propanediol, 1,2-propanediol, 1,3-propanediol, polypropylene glycol, 1,2-butyl Diol, 1,3-butanediol, 1,4-butanediol, isopentanediol, pentylene glycol, hexylene glycol, 1,3-pentanediol, 1,4-pentanediol, 1,2,3-pentanetriol, 2,3,4-pentanetriol, 1,3,4-pentanetriol, 1,3,5-pentanetriol, 1,3-hexanediol, 1,4-hexanediol, 1,5-hexanediol, 1, 2,3-hexanetriol, 1,3,4-hexanetriol, 1,3,5-hexanetriol, 1,4,6-hexanetriol, erythritol, pentaerythritol, dipentaerythritol, threitol, arabitol, xylitol, Ribitol, galactitol, lactitol, maltitol, inositol, panthenol, laminitol, valienamine, validamine, validatitol, trehalose Is a derivative thereof, D-mannosamine and a derivative thereof, isomaltoligosaccharide (panose), primeverose or a derivative thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, alkylene (C2 to C4) oxide such as ethylene oxide Hydroxyalkyl (C2-C4) chitin or chitosan to which is added, low molecular chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or Its salts, β-1,3-glucan, β-1,4-glucan, β-1,6-glucan, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose, carboxyethylcellulose, sodium carboxyethylcellulose, Roxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, hydroxypropyl methylcellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide, or cross-linking polymerization thereof Water-soluble polymers such as carboxyvinyl polymer, polyethyleneimine, dermatan sulfate, keratan sulfate, glycerin fatty acid pyrrolidone carboxylic acid ester, glycerin fatty acid acetyl amino acid ester, pyrrolidone carboxylic acid or salt thereof, polyaspartic acid or salt thereof Polyglutamic acid or a salt thereof, polylysine or a salt thereof, sodium lactate, hydantoin and Its derivatives, Np-vinylbenzyl-D-cellobionamide, Np-vinylbenzyl-D-lactone amide, Np-vinylbenzyl-D-maltonamide, Np-vinylbenzyl-D-gluconamide, glucosyloxyethyl methacrylate, galactosyl Oxypropyl acrylate, mannosyloxyethyl methacrylate, glutamyl lysine, glutaurine, 1,2,4-butanetriol, caran-3,4-diol, azoxaponin (3-o- [β-D-glucopyranosyl-β-D-glu Chronopyranosyl] -sophoradiol, 3-o- [β-D-glucopyranosyl-3-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D -Glucuronopyranosyl] -azuxapogenol, 3-o- [β-D-glucopyranosyl] -28-o- [β-D-glucopyranosyl-β-D-glucopyranosyl] -dipsogenic acid, 3-o- [α-L-Rhamnopyranosyl-β-D-G Lucopyranosyl-β-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -29-o- [β-D- Glucopyranosyl-β-D-glucopyranosyl] -azuxapogenol, etc.), Aoki (Aoki) extract, Aogiri extract, Kenashia Ogiri (Akatsuki) extract, Red clover extract, Red clover extract, Akikara pine extract, Aguahe (Omitenga palm) extract , Maruba morning glory extract, morning glory extract, athira (shokuyo kanna) extract, oilseed rape extract, amachazul extract, amana extract, sunfish extract, hagateto extract, scallop extract, garlic extract, sugimorige Ito extract, Hosoa Otome extract, Aogateto extract, Haribiyu extract, Aozuzuran extract, Amaranthus hippochondriax extract, Aristolomeria (Yurizuisen) extract, Alcana (alcanna) extract, Argarobo (cabbage) extract, Aloe vera extract, Rabbit extract (Yellow grass) extract, Yew (first place) extract, Strawberry extract, Carob extract, Inazuna (Tailexi) extract, rice extract, dog mint extract, sardine tobacco (Iwatsuki) extract, sardine hiba extract, sardine pine (roll mushroom) extract, wheat (chibusanoki) extract, duckweed (float) extract, euglena extract Uncaria extract, Enokitake mushroom extract, Eringi extract, Pre-lotus eringi extract, Ogata Hakken extract, Oguruma (civil engineering incense) extract, Oohushigusa (cereal essence) extract, Okaeki , Okazeri (snake bed) extract, Okra extract, Onidokoro extract, Tokoro extract, Nagadokoro (hikai) extract, Ononis extract, Yuuko extract, Oyster extract, Ginseng extract, Gaku hydrangea extract, Cascara sagrada extract, Gypsophila extract , Panax ginseng extract, cane extract, carnation extract, gerbera extract, camcam (camo duck) extract, color extract, oats extract, karin extract, kawara psycho (compulsed rye, extract), kawajisha extract, kawaranadeshiko (stone bamboo) extract , Ezokawaranadeshiko (buckwheat noodles, buckwheat) extract, Kantara Asa extract, Kikutanigiku extract, Quinua (quinoa) extract, cabbage extract, kiwi extract, cucumber extract, gyory (Nishikawa willow) ) Extract, Kiranso (Kinza hay) extract, guayule extract, Kusugi katsura (Tenmon winter) extract, Kudzu (Kazunori) extract, xanthus carp (yellow flower bud) extract, Kupuas extract, Gumbanazuna (Sekimei, Sekimeishi) extract, Kemponashi (Kigushi) Extract, Geckavidin (Beautiful Beauty) Extract, Koolen (Huo Ren) Extract, Coconut Extract, Cosmos Extract, Coconut Peel Extract, Rice Oil Extract, Konjac Extract, Saffron (Bansai Flower, West Red Flower) Extract, Sapodilla Extract, Sangre Degrad ( Croton extract, sancitin ginseng (37 ginseng) extract, shea (carite) extract, cyanoki extract, shiitake extract (shiitake) extract, shimeji mushroom extract, hinoki shimeji mushroom extract, shaka shimeji mushroom extract, hatake shimeji mushroom extract, oscillating shimeji mushroom extract, beech shimeji mushroom extract Kiss, Honjimeshi Extract, White-winged Mushroom Extract, Shimokuren Extract, Saishin Extract, Cactus Extract, Janohige (Bakumon Winter) Extract, Shukukonkasamisu Extract, Ganzan Hydrangea (Tsukuyama) Extract, Shirochochou Extract, White Azuki Bean (Chicken Bone) Grass) extract, Zinchoge (Mizuka, Mizuka flower, Shencho flower) extract, Watermelon (Seijo) extract, Suzu-Psycho (Xucho) extract, Surihiyu (Horse tooth extract, Horse tooth soap) extract, Sekkok extract, Sakura Sekkoku extract, Koki Sekkoku extract , Obanasekkokku extract, Okinawakekkukku extract, Honsekokukoku extract, moth-knotukukoku extract, deer-kokukokukoku extract, kibanano-sekkok extract, cedron extract, mallow extract, celery extract, senshinren Extract, Japanese radish extract, Takasaburo extract, Tachidokoro (hikai) extract, Dahlia (Tenjiku button) extract, Talwei extract, Senganshi extract, Sojitsu extract, Chankapiedora extract, Tulip extract, Chorogi extract, Tsukuritake (mushroom) extract, camellia extract, clover (lacquered licorice) extract, Tounabena (river cut) extract, corn extract, corn hair (Southern cocoon hair) extract, Toxa (wood bandage) extract, ash (skin) extract, Turkish Kyary Extract, Solid Bean Extract, Vertical Haki Extract (Sword Bean) Extract, Jujube (Daisatsu) Extract, Navena (Continued) Extract, Nameko Extract, Namban Karamushi (Cannabis) Extract, Niooi Sumire Extract, Nikuzu Extract, Nemunoki Extract, Nebu Kiss, Nebi extract, Nemuri extract, Digokubana extract, Nogateito extract, Hylindough extract, Hauchiwa extract, Hauchi bean extract, Papaya extract, Pahalobobo extract, Barata rubber extract, Agaric extract, White-faced agaric extract, Usukimorinokasa extract, Haran extract, Parisurus (Prunus edulis) extract, balsamina (crane licorice, bitter gourd) extract, harlindough extract, handdai kai (sea bream sea) extract, hygurum dahlia extract, beet extract, hiba extract, sunflower extract, bell pepper extract, himeuzu (tendon) extract, himematsutake (kawariharatake) , Hiromatsutake) extract, Euphorbiaceae extract, Brazilian daylily extract, hazelnut extract, loofah extract, crassulaceae Extract, nettle extract, scallop extract, sardine extract, nendo extract, scallop extract, ground scallop extract, spinach (aden, acute chick, pellucid) extract, scallop extract, sorghum 7) Extract, jojoba extract, Borage extract, Bordeaux extract, Hononiku (meat jujube, Daiki) extract, Honsekkok (iron crust stone, sparrow mountain stone agate) extract, maca extract, macadamia nut extract, margaret (mokushungiku) extract , Tamanosen Hallen extract, Kyukonkinrenka extract, Matatabi (wooden cocoon) extract, Matsukasa extract, Matsuhodo (potato) extract, Matico (cordon sillo) extract, Quince extract, Malene (Biloud mud squid) extract, Manzanya (Andesca chamomile) Extracts, Psyllium extract, Papilion extract, Green mint extract, Wheat straw extract, Munya extract, Purple extract, Purple purple extract, Purple nectar wisteria extract, Moge extract , Cinnamon extract, cornflower extract, yacon extract, palm extract, yabu tobacco (crane candy, Tenmeisei) extract, malonie extract, mokka extract, lily extract, ligan extract, lime extract, rye extract, rakkyo extract, shallot (white) ) Extract, apple extract, gentian extract, litchi (piper, edible nucleus) extract, forsythia extract, yokuinin extract, minisasaniki extract, chlorella vulgaris extract, chlorella pyrenoid extract, chlorella e Pseudiaia extract, Macrocystis pirifera extract, Yuikiri extract, Tosakanori extract, Cyprinus extract, Amakusanori extract, Aoumidro extract, Kawanori extract, Marimo extract, Motsukikitoe extract, Ezoyahaz extract, Habanori extract, Habanori extract, Watamo extract, Amame extract , Sujime extract, trochokonbu extract, antokume extract, pickled arame extract, black squirrel extract, cat corn extract, Ainu turtle extract, tigaiso extract, squirrel extract, yabanemoku extract, trumpet extract, uganomok extract, jolomok extract, hyamok extract, tamanashi moku extract, honda Extract Sanori Extract, Hosobanamino Hana Extract, Hanafnori Extract, Itofonori Extract, Kaginori Extract, Mirin Extract, Hosobamilin Extract, Kikutosaka Extract, Ezonameshi Extract, Ibaranori Extract, Kagyi Baranori Extract, Saidaibara Extract, Tatyibara Extract, Ogonori Extract, Examples include tsurushiramo extract, honey beetle extract, red clover extract, red ginseng extract, natto fungus culture metabolite, natto extract, loofah water, birch (white birch) or red pine sap.

Cell activating agent / metabolic activator A cell activating agent / metabolic activator can be added to the present invention. Specific examples of cell activators and metabolic activators include vitamin A group: retinol or its salts and derivatives thereof (retinyl unsaturated fatty acid esters such as retinyl linoleate, retinyl linolenate, retinyl oleate, retinyl arachidonic acid, etc.) ), Retinal or a salt thereof and derivatives thereof, dehydroretinal or a salt thereof and derivatives thereof, retinoic acid or a salt thereof and derivatives thereof, retinoic acid analogs (4-[[[8- (3,5-dimethylphenyl ) -2-Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3-methylphenyl) -2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[[8- (4-methylphenyl) ) -2-Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3,4- Dimethylfe Nyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2,4-dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2 -Isopropylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-ethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2 -Fluorophenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methoxyphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(8-benzyl- 2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[(E) -2- (8-phenyl-2-naphthalenyl) propenyl] benzoic acid), retinoic acid derivative (4-hydroxyphenylretinamide), retinoid analogues (4-[[(5,6-dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[(5, 6-dihydro-5,5,8-trimethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) amino] Carbonyl] benzoic acid,
4-[[((5,6-Dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5,8-trimethyl -2-Naphthalenyl) -carbonyl] amino] benzoic acid, 4- (E)-[2- (5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) -1-propenyl] benzoic acid , 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) oxy] carbonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl- 8-Phenyl-2- (naphthalenyl) carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] oxy] benzoic acid, 4 -[[5,6-dihydro-5,5-dimethyl-8- (2-fluorophenyl) -naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5,6- Trimethyl] -8-phenyl-2- (naphthalenyl) carbonyl] amino] benzoic acid, 4-[[(5,6-dihy B-5,5,7-trimethyl-8-phenyl-2-naphthalenyl) carbonyl] benzoic acid, 4-[[((E)-(5,6-dihydro-5,5-dimethyl-8-phenyl) -2 -Naphthalenyl] vinyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] sulfamyl] benzoic acid, 4-[[[((5, 6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] sulfamyl] carbonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl ] Ethyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] thiocarbonyl] amino] benzoic acid, 4-[[[((5,6 -Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] methyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2- Naphthalenyl] methyl] oxy] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl)- 2-naphthenyl] oxy] methyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8- (2,4-dimethylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid Acid 4-[[[(5,6-dihydro-5,5-dimethyl-8- (4-methylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5,6- Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] sulfamyl ] Methyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] amino] benzoic acid, 4-[[[((5,6-dihydro -5,5-dimethyl-8-phenyl) -2-naphthalenyl] amino] thiocarbonyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl ] Methyl] sulfamyl] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphtha Nyl] amino] methyl] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-hydroxybenzoic acid, 4- [ [[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-nitrobenzoic acid, 4-[[[((5,6-dihydro-5,5 -Dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-fluorobenzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] carbonyl ] Amino] -2-methoxybenzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8- (2-naphthalene)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4- [[((5,6-Dihydro-8-phenyl-2-naphthalenyl) carbonyl] aminobenzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) carbonyl] Amino] -3-fluorobenzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8- Enyl-2-naphthalenyl) carbonyl] amino] -3-methylbenzoic acid, 4-[[(5,8,10,10a-tetrahydro-10,10-dimethyl-9-phenyl-2-anthracenyl) carbonyl] amino] Benzoic acid, 4-[[(1,1-dimethyl-3-phenyl-1H1-inden-5-yl) amino] carbonyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-indene -5-yl-oxymethyl) benzoic acid, 4- [2- (1,1-dimethyl-3-phenyl-1H-inden-5-yl) vinyl] benzoic acid, 4-[(1,1-dimethyl- 3-phenyl-1H-indene-5-carbonyl) amino] benzoic acid), carotene or salts thereof and derivatives thereof (α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthine, lutein, zeaxanthin, isoseaxanthin, rhodoxanthine , Carotenoids such as capsanthin and crocetin), lycopene or salts thereof and derivatives thereof Vitamin B group: thiamine or a salt thereof and derivatives thereof (thiamine hydrochloride, thiamine disulfide, bisbenchamine, bisivethiamine, thiamine monophosphate disulfide, benfotiamine, chicotiamine, octothiamine, dicetiamine, fursultiamine, pro Sultiamine, astaxanthin thiamine phosphate diester, etc.), thiamine sulfate, riboflavin or its salts and derivatives thereof (flavin adenine dinucleotide, flavin mononucleotide, riboflavin phosphate diester, 1-β-D-ribofuranosylnicotinamide pyrroline) Acid diesters, 1-β-D-ribofuranosylnicotinic acid, etc.), pyridoxine or its salts and derivatives thereof (pyridoxine 3,4-dipalmitate, pyridoxine 3,4-dicaprylate, pyridoxine sulfate) Diesters, etc.), pyridoxal or salts thereof and derivatives thereof, pyridoxamine or salts thereof and derivatives thereof, cyanocobalamin or salts thereof and derivatives thereof, cobalamines (methylcobalamin, adenosylcobalamin, hydroxocobalamin, aquacobalamin etc.), folic acid Or salts thereof and derivatives thereof, nicotinic acid or salts thereof and derivatives thereof, pantothenic acid or salts thereof and derivatives thereof, biotin or salts thereof and derivatives thereof, choline or salts thereof and derivatives thereof, inositol or salts thereof And derivatives thereof, vitamin C group: ascorbic acid or a salt thereof and derivatives thereof, vitamin D group: ergocalciferol or a salt thereof and derivatives thereof, cholecalciferol and a salt thereof and the like Derivatives (1α-Hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1R, 4R ] -1α-Hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1R, 4S ] -1α-Hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1S, 4R ] -1α-Hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1S, 4S ] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, etc.), dihydrotaxi Sterols or salts thereof and derivatives thereof, vitamin E group: Tocopher Or salts thereof and derivatives thereof, tocotrienol or salts thereof and derivatives thereof, ubiquinone or salts thereof and derivatives thereof, vitamin K group: phytonadione or salts thereof and derivatives thereof, menaquinone or salts thereof and derivatives thereof, Menadione or salts thereof and derivatives thereof, menadiol or salts thereof and derivatives thereof, vitamin F group: linoleic acid or salts thereof and derivatives thereof, linolenic acid or salts thereof and derivatives thereof, arachidonic acid or salts thereof and the like Derivatives, carnitine or salts thereof and derivatives thereof, ferulic acid or salts thereof and derivatives thereof, γ-oryzanol or salts thereof and derivatives thereof, orotic acid or salts thereof and derivatives thereof, vitamin P group: rutin or a salt thereof Salt and it Derivatives thereof, eriocitrin or salts thereof and derivatives thereof, hesperidin or salts thereof and derivatives thereof, vitamin L group: anthranilic acid or salts thereof and derivatives thereof, adenylthiomethylpentose or salts thereof and derivatives thereof, vitamins Group U: methylmethionine sulfonium chloride or derivatives thereof, valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, asparagine Acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine or derivatives thereof (N-octyloxycarbonyl-β-alanyl-L-histidine, N-dodecyloxycar Nyl-β-alanyl-L-histidine, N- (12-amino-1-oxododecyl) -L-histidine, N-2-ethylhexyloxycarbonyl-β-alanyl-L-histidine hydrochloride, N-hexadecyloxy Carbonyl-β-alanyl-L-histidine, N-octylaminocarbonyl-β-alanyl-L-histidine, N-dodecylaminocarbonyl-β-alanyl-L-histidine, N-dodecylsulfonyl-β-alanyl-L-histidine N-dodecylamino-oxalyl-β-alanyl-L-histidine, etc.) and their amino acids such as sulfates, phosphates, nitrates, citrates, or pyrrolidone carboxylic acids, glycolic acid , Citric acid, malic acid, tartaric acid, lactic acid, succinic acid and other α-hydroxy acids, 2-hydroxycarboxylic acids (methyl lactic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2-hydride) Roxyhexanoic acid, 2-hydroxyheptanoic acid, 2-hydroxyoctanoic acid, 2-hydroxynonanoic acid, 2-hydroxydecanoic acid, 2-hydroxyundecanoic acid, α-hydroxylauric acid, α-hydroxymyristic acid, α-hydroxypalmitin Acid, α-hydroxystearic acid, α-hydroxyarachidonic acid, cerebronic acid, α-hydroxynervonic acid, mandelic acid, benzylic acid, phenyllactic acid, atrolactic acid, 2- (4'-hydroxyphenyl) -2-hydroxyethanoic acid 2- (4′-chlorophenyl) -2-hydroxyethanoic acid, 2- (3′-hydroxy-4′-methoxyphenyl) -2-hydroxyethanoic acid, 2- (4′-hydroxy-3′-methoxyphenyl) ) -2-Hydroxyethanoic acid, 3- (2'-hydroxyphenyl) -2-hydroxypropanoic acid, 3- (4'-hydroxyphenyl) -2-hydroxypropanoic acid, 2- (3 ', 4'-dihi Roxyphenyl) -2-hydroxyethanoic acid, glyceric acid, erythronic acid, ribbon acid, arabinonic acid, xylonic acid, lyxonic acid, aronic acid, altronic acid, gluconic acid, mannonic acid, gulonic acid, idonic acid, galactonic acid, talon Acid, glucoheptonic acid, galactoheptonic acid, tartronic acid, mucinic acid, etc.), polyhydroxycarboxylic acid or hydroxypolycarboxylic acid (gluconolactone, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, sugar lactone) Pantoyl lactone, glucoheptonolactone, mannonolactone, galactoheptonolactone, etc.), 2-keto acids (glyoxylic acid, methyl 2-ketoethanoate, benzoylformic acid, methyl benzoylformate, ethyl benzoylformate, Binic acid, methyl phenylpyruvate, ethyl phenylpyruvate, 2-ketobutanoic acid, 2-ketopentanoic acid, 2-ketohexanoic acid, 2-ketoheptanoic acid, 2-ketooctanoic acid, 2-ketododecanoic acid, methyl 2-ketooctanoate) , Quinic acid, isocitric acid, tropic acid, tretocanic acid, 3-chlorolactic acid, cerebronic acid, citramalic acid, agaricinic acid, alloyic acid, pantoic acid, lactobionic acid, hexulosonic acid, photosensitizer 301, hinokitiol, pantothenic acid Derivatives, allantoin, pentadecanoic acid glycerides, linolenic acid or derivatives thereof, eicosapentaenoic acid or derivatives thereof, docosahexaenoic acid or derivatives thereof, estradiol, ethenyl estradiol, antialol or glycosides thereof, rioniresinol or glycosides thereof, rhododendone Or glycosides thereof, platifironol or glycosides thereof, lactone compounds (D-glucurono-6,3-lactone, α-D-glucoheptonic-γ-lactone, δ-glucuronolactone, α, β-glucooctonic-γ-lactone, L-glonic-γ-lactone, γ-D-galactonolactone, D-saccharide-1,4-lactone, D-saccharide-3,6-lactone, D-ribonic- γ-lactone, α-butyrolactone, γ-butyrolactone, α-octanoic lactone, γ-octanoic lactone, nonanoic lactone, γ-valerolactone, D-manninoic-δ-lactone, D-xyloic-δ-lactone , D-arabinoic-δ-lactone, stearoyl-δ-gluconolactone, DL-pantolactone, palmitoyl-DL-pantolactone, etc.), 3-hydroxy-3,4-dicarboxy-1,4-butanolide or its derivatives , 6- Nidylaminopurine or its derivatives, 1,4-diazadicyclooctane, 2,5-dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran, rutin, tectrigenin 7-xylo Sylglucoside, captopril, alaspril, lisinopril, enalapril, delapril, benazepril, cilazapril, imidapril, quinapril, trandelapril, perindopril, temocapril, losartan, endothelin, galactomannan saccharide polymer, mucin, trimethylglycine, proteoglycan extract, proteoglycan extract Culture liquid extract, lactic acid bacteria fermented milk extract, bifidobacteria extract, bifidobacteria culture liquid extract, bifidobacteria fermented milk extract, placenta extract, ganoderma extract, spleen extract, thymus extract, yeast extract, yeast culture Nutrient extract, yeast fermentation extract, filamentous fungus extract, filamentous fungus culture fluid extract, basidiomycete extract, basidiomycete culture fluid extract, bacterial cell disruption extract, bacterial culture extract, cultured human dermal cell disruption extract, red sage ) Extract, fennel (yuka) extract, Ezokogi (barley gourd) extract, barley (barley) extract, oakuri higotai (Zhengzhou leakage) extract, komeba hypericum extract, hypericum perforatum extract, holland jelly extract, dutch honey beet extract, Silkworm extract, Roman chamomile extract, Garcinia extract, Kawaranin ginseng (blue cocoon) extract, oyster extract, quilla extract, quinlan extract, ginkgo biloba extract, calendula extract, sakaneran extract , Citrus extract, shajin extract, plum extract, walnut extract, horsetail extract, pineapple extract, Chinese cabbage extract, cypress extract, beech extract, physalis extract, Maitake extract, Misohagi (Chikuma) extract, Mukuge (Kiso) extract, Mukuroji (life-extending skin) extract, Palm extract, Eucalyptus extract, Yukinoshita (tiger ear grass) extract, Suabisimus extract, Lettuce (Chisha) extract, Aloe extract , Ogon extract, Tonka bean extract, Gentiana extract, Burdock extract, Shikon extract, Carrot extract, Clam extract, Hop extract, Yokuinin extract, Odorikosou extract, Sembli extract, Toki extract, Tochinsen extract, Achacha extract, Otogiri Extract of cucumber, extract of cucumber, rosemary extract, parsley, extract of sandagusa, extract of fukurinamiji, extract of katsuracombu extract, extract of kakimacombu extract, onicombu extract, extract of corncomb extract, peacomb extract, oo Examples include Chijimi Kombu extract, Rattle extract, Rattle extract, Beni Mozuku extract, Hoso Beni Mozuku extract, Kagekinori extract, Ezotosaka extract, Silamo extract and Birch extract.

Antioxidant An antioxidant can be added to the present invention. Specific examples of the antioxidant include ascorbic acid or a salt thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl hydroxyprophosphate ester,
5-o-α-D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphorus Acid ester calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt , L-ascorbic acid sulfate aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α -D-Galactopyranosyl-L-ascorbic acid, 2-o-β-D-Ga Ctopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6 -o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl-L-ascorbic acid, 6-o-alkyl ascorbic acid phosphate potassium salt, 6-o-alkylascorbic acid phosphate calcium calcium salt, 6-o-alkylascorbic acid phosphate barium salt, 6-o-alkylascorbic acid phosphate ammonium salt, 6-o-alkylascorbic acid phosphate mono Ethanolamine salt, 6-o-alkylascorbic acid phosphate Terdiethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine salt, 6 -o-alkyl ascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate cholesterol ester, L-ascorbyl palmitate, L-ascorbyl isopalmitate, L-ascorbyl dipalmitate, L-ascorbyl diisopalmitate, L-ascorbyl stearate, L-ascorbyl isostearate, L-ascorbyl distearate, L-ascorbyl diisostearate Ascorbyl, myristic acid L- Ascorbyl, isomyristic acid L-ascorbyl, dimyristic acid L-ascorbyl, diisomyristic acid L-ascorbyl, 2-ethylhexanoic acid L-ascorbyl, di-2-ethylhexanoic acid L-ascorbyl, oleic acid L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o -α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, L-ascorbic acid tetra Isopalmitate,
L-ascorbic acid tetralauric acid ester, L-ascorbic acid tetra-2-ethylhexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid trilin Acid ester, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxy Ferrate, DL-α-tocopherol-2-L-ascorbic acid phosphate diester, ascorbic acid inositol binding inducer Conductor, ascorbic acid phosphoramide derivative, ascorbic acid arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative, etc.), stearic acid ester, tocopherol or a salt thereof and derivatives thereof (α-tocopherol, β- Tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate, tocopherol succinate, tocopherol reno Rate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucosi DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl Glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-toco Ferryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ- Tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- (sulfoethylamino) -3- (α-tocopheryl-6-iroxy ) Propan-2-ol, 1- (Carboki Propylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] cysteine, S -[3- (α-Tocopheryl-6-Iroxy) -2-hydroxypropyl] -γ-Glutamylcystenylglycine, N- [3- (α-Tocopheryl-6-Iroxy) -2-hydroxypropyl ] Aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol) , Δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate), dihydropyridy Derivatives (methyl-3-phenyl-2-propenyl
1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) pyridine-3,5-dicarboxylate and its salts), benzochroman derivatives, nordihydrogua cetelenic acid, butylhydroxytoluene (BHT) , Butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, coenzyme Qn (n = 7-10), pyrroloquinoline quinone, propyl gallate, sesamol, sesamorin, gossypol, maritimaine, sulfretin, xanthene-2,7- Diols, caffeoylquinic acids, propolis, carotenoids (α-carotene, β-carotene, γ-carotene, lycopene, lutein, violaxanthin, spiroloxanthine, spheroidene, astaxanthin, etc.), phlorotannins, akebi (trees) Extract, Achacha extract, Oolong Chae , Dutch sweet potato extract, kanran extract, kumquat extract, gobisy extract, geno shochu (old licorice) extract, sesame extract, sesame cell extract, sesame extract, rice bran extract, pomegranate extract, salamander extract, pear Extract, Daio extract, tomato extract, Nanten extract, Noisami extract, Neubara extract, paprika extract, pistachio extract, betel wax extract Bokeh (Kiso) extract, Hosobaoguruma extract, Mao (mao) extract, Mimosa extract, Mebouki extract, Japanese black willow extract, Willow tree extract, Watafujitsugi extract Examples include sea urchin extract, hypericum extract, clam extract, clove extract, enme iso extract, birch extract, salvia extract, rosemary extract, southern berry extract, ginkgo biloba extract, green tea extract, clove extract and the like.

Active oxygen scavenger / radical scavenger An active oxygen scavenger / radical scavenger can be added to the present invention. Specific examples of active oxygen scavengers and radical scavengers include superoxide dismutase, catalase, glutathione peroxidase, bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or derivatives thereof, gallic acid or salts thereof, and derivatives thereof, curcumin Or salts thereof and derivatives thereof, transferrin, ceruloplasmin, coenzyme Qn (n = 7 to 10), uric acid, bilirubin, metallothionein, stilbengaloyl glycoside (3,5,4′-trihydroxystilbene 4′-o -β-D- (6 "galloyl) glucopyranoside, 3,5,4'-trihydroxystilbene 4'-o-β-D- (2" galloyl) glucopyranoside, etc.), chlorogenic acid phospholipid ester, chlorogenic acid sphingosine ester And derivatives thereof, chlorogenic acid glycolipid ester, black Rogenic acid sugar ester, chlorogenic acid sterol ester, thiazole derivative or salt thereof (2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxyphenyl) thiazole, 2- (3,4-di Ethoxyphenyl) -4- [3-carboxy-4-hydroxy-5- (2-methyl-2-propenyl) phenyl] thiazole and 2- (3,4-diethoxyphenyl) -4- (3-carboxy-4 -Hydroxy-5-methylphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- (3-carboxy-5-methoxyphenyl) thiazole), hydroxymatylesinol, allohydroxymatylesinol, hydantoin derivatives , Akaminoki (logwood) extract, Akamegashiwa (red buds) extract, Akamino Akane extract, Acacia akane extract, Akane (Hakusai) extract, Hydrangea (hydrangea) extract, Abemaki extract, Chijiku extract, Ginkgo biloba extract, Asparagus extract, Japanese apricot extract, Vulcania serrata extract, Japanese walnut extract, Estragon extract, Enju (Safflower, Satsuma rice) extract, Kashiwa (Shinoki, Kashiwa) extract , Genus extract, birch extract, birch extract, cucumber extract Extract, Sasa (Amber) Extract, Perilla Extract, Ajizo Extract, Chimmento Extract, Catamen Diso Extract, Quercus Extract, Citrus Extract, Crape Myrtle Extract, Zicopi Extract, Shirakashi Extract, White Clover Extract (Clover) Extract, Sei Horseradish extract, black tea extract, green tea extract, camellia extract, tencha (tea) extract, tender eel extract, nani waibara (gold cherry) extract, peanut extract, kei extract, nikkei extract, ceylon nikkei extract, yabuniki cinnamon extract, keishi ( (Keishi) extract, Nozenkazura (Lyoen flower) extract, Lotus (Lotus) extract, Chinese cabbage extract, Hadakagi extract, Hanasuge (my mother) extract, Hermanus (Maikai flower) extract, Rose (Rose) extract, Barbasco extract, Spinach extract, Beech extract, American beech extract, Inu beech extract, European beech extract, Convolvulus extract, Hosobaokera extract (蒼朮) extract, Button (peony) extract, Mayoram (Annelida) extract, Melon extract, Oenothera extract, Yukiya Examples include nagi extract, orchid extract, lacanka extract, rooibos extract, naminohana extract, eucalyptus extract, judo eucalyptus extract, azusa extract, basil extract, mokko (wood fragrance) extract, himefuuro extract, lemongrass extract and the like.

Fat Metabolism Promoter A fat metabolism promoter can be added to the present invention. Specific examples of fat metabolism promoters include phthalazine derivatives (4-ethyl-1- (β-hydroxyethylamino) phthalazine, 4-N-propyl-1- (β-hydroxyethylamino) phthalazine, 4-N-butyl- 1- (β-hydroxyethylamino) phthalazine, 4-N-butyl-1- (β-hydroxypropylamino) phthalazine, etc.), xanthine derivatives (caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, diprofylline, proxy) Phyllin, oxtriphilin, etc.), Aotsuki-rafuji (wooden candy) extract, thistle extract, aletia thistle extract, mite thistle extract, scrub thistle extract, noel thistle extract, blue thistle extract, cacao extract, elcampuri extract, otsu-rafuji (preventive self) Extract, banquet extract, Karaku salmon man Kiss, Kyoukyo (Kikkyo, Kikyo Root) Extract, Ivy Extract, Pepper (Pepper) Extract, Cola Acuminata Extract, Sagiomodaka (Sawamata) Extract, Pomelo Extract, Sanshuyu (Yamatake) Extract, Tsutsu Rafu Extract, Otsu Samurai Extract, Chorei Maitake (猪苓) Extracts, Cranella extract, Proboscis extract, Ginseng extract, Korean ginseng extract (Ryu gall) extract, Naginata kouju extract, Banana extract, Puer tea (common ear tea) extract, Plum extract, Buufu (windproof) extract, etc. It is done.

UV protection agent / UV absorption promoter An UV protection agent / UV absorption promoter can be added to the present invention. Specific examples of UV protective agents and UV absorption accelerators include benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5- Sodium sulfonate, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), 1,2-dihydroxy-4- (2-hydroxyethyl) benzene derivatives (1- (2- (4- (3,4-Dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) -3- Rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (2-acetyl-4- (3,4-dihydride) Xycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (2-acetyl-6- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3, 4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (6- (4-hydroxy -3-methoxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1- Methoxyethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-hydroxyethyl-3,4-dihydroxybenzene, 1- ( 2- (6- (3,4-Dihydroxycinnamoyl) -3-xylosyl) glucosyl) eth Ru-3,4-dihydroxybenzene, 1- (2- (3-allosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- ( 3-glucosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (3-arosyl-6- (3-hydroxy-4-) Methoxycinnamoyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2 -(3- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (2- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4 -Dihydroxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydride Xylbenzene, etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc.), methoxycinnamate derivatives (ethyl paramethoxycinnamate, paramethoxy, etc.) Isopropyl cinnamate, octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, glyceryl di-2-methoxycinnamate mono-2-ethylhexanoate), anthranilic acid derivatives (such as methyl anthranilate) , Urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimi Derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, pyridoxine derivatives, pyridoxal derivatives, pyridoxamine derivatives, amethoflavone, neosacranine, 6-dehydrocaine, triazine derivatives (4,4 '4 "-(1,3,5-triazine-2,4,6-triyltriimino) trisbenzoic acid tris-2-ethylhexyl, etc.), phosphatidylchromanol derivatives (1,2-dilaurolylglycero-3- Phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-dimyristoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6'-hydroxychroman, 1,2-dipalmitoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl -6'-hydroxychroman, 1,2- Stearoyl glycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-dialachidonylglycero-3-phospho-2'- Hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-myristoyl-2-palmitoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7 ', 8'-Tetramethyl-6'-hydroxychroman, 1-myristoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6 ' -Hydroxychroman, 1-palmitoyl-2-myristoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-palmitoyl-2- Stearoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-stearoyl-2-myristoylglycero-3-phospho-2'- Hydroxyme 2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-stearoyl-2-palmitoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7' , 8'-tetramethyl-6'-hydroxychroman, etc.), L-carnosine zinc complex, umbelliferone, esculin, benzyl cinnamate, cinoxalate, oxybenzone, dioxybenzone, octabenzone, soribenzone, benzoresorcinol, arbutin, guaiazulene, Shikonin, baicalin, baicalein, berberine, neoheliopan, chlorophylls, xanthophylls, escalol, zinc oxide, talc, kaolin, anthracite extract, hub extract, giant rush extract, cassava extract, kawatake extract, islet jellyfish extract , Hassai extract, Spirulina extract , Aiacacio extract, Funori no Ushike extract, Himetengususa extract, Hytengususa extract, Oobusa extract, Chinomori extract and the like.

Astringents Astringents can be added to the present invention. Specific examples of astringents include succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannins (tannic acid, hammelitannin Acer tannin, tetragalloyl glucose, pentagalloyl glucose, hexagalloyl glucose, heptagalloyl glucose, octagalloyl glucose, nonagaroyl glucose, decagalloyl glucose, undecagalloyl glucose, dodecagalloyl glucose, etc. Gallotannins, telimaglandin I, telimaglandin II, casarictin, peduncraggin, geraniin, isoturkevin, granatin A, granatin B, ketulinic acid, keblagic acid, casuarinin, nuphalin, procyanidin B-2 Ellagitannins such as thiacinensin A and thiacinensin B), red grape grape extract, azuki bean (red bean) extract, altea extract, nettle extract, cascarilla extract, kapoch extract, guarana extract, ezo strawberry extract, Dutch strawberry extract, shrimp strawberry extract , Nawashiro strawberry extract, Momiji strawberry extract, European raspberry extract, Kidachi aloe extract, Hawthorn extract, Cowberry extract, Coke bella extract, Sugar cane extract, Sinah onion extract, Honeysuckle extract , Larch extract, elder extract, dandelion extract, centarium extract, white dandelion extract, moco dandelion extract, cranberries extract, tsurutsia Pepper extract, Teuchigurumi extract, Tormentilla extract, Novara extract, Firefly extract, Hagoromogusa extract, Castor extract, Grape extract, Prunes extract, Veronica extract, Bisnaga extract, Bilberry extract, Mango walnut extract, Mitsuga wrinkle extract, Myrrh extract, Mansaku extract, Doryanagi Extract, Latania (Clamelia) extract, lemon extract, corn poppy extract and the like.

Anti-inflammatory agent / interleukin production inhibitor / histamine release inhibitor An anti-inflammatory agent / interleukin production inhibitor / histamine release inhibitor can be added to the present invention. Specific examples of anti-inflammatory agents, interleukin production inhibitors and histamine release inhibitors include quinolinone derivatives, dibenzooxepin derivatives, thiotroposin, phthalimide derivatives, flurbiprofen, felbinac, bufexamac, suprofen, 1,4-diphenylpropyl Piperazine derivatives, carxin compounds, chromanol glycosides (2- (α-D-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol), ictamol, indomethacin, kaolin, diphenhydramine hydrochloride, d- Camphor, DL-camphor, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, diphenhydramine hydrochloride, clemastine fumarate, cyproheptadine hydrochloride, Promethazine hydrochloride, piperazine derivatives, α-D-phenylglycoside derivatives, glycyrrhizic acid or salts thereof and derivatives thereof (α-glycyrrhizic acid, β-glycyrrhizic acid, α-glycyrrhizic acid methyl ester, β-glycyrrhizic acid methyl ester, α- Trisodium glycyrrhizinate, monopotassium α-glycyrrhizinate, dipotassium α-glycyrrhizinate, monoammonium α-glycyrrhizinate, trisodium β-glycyrrhizinate, monopotassium β-glycyrrhizinate, dipotassium β-glycyrrhizinate, β-glycyrrhizic acid mono Ammonium), glycyrrhetinic acid or a salt thereof and derivatives thereof (α-glycyrrhetinic acid, β-glycyrrhetinic acid, stearyl α-glycyrrhetinic acid, stearyl β-glycyrrhetinic acid, pyridoxyl α-glycyrrhetinic acid , Β-glycyrrhetinic acid pyridoxine, α-glycyrrhetinic acid glycerin, β-glycyrrhetinic acid glycerin, 3-succinyloxyglycyrrhetinic acid disodium, etc.), mefenamic acid, phenylbutazone, ibuprofen, ketoprofen, allantoin, calcium pantothenate, pantothenylethyl Panthenol such as ether or salts thereof and derivatives thereof, ε-aminocaproic acid, diclofenac sodium, tranexamic acid or derivatives thereof (trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-nitrobenzyloxycarbonyl Aminomethylcyclohexanecarboxylic acid, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-bromobenzyloxycarbo Ruaminomethylcyclohexanecarboxylic acid, trans-4-m-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methylbenzyloxycarbonylamino Methylcyclohexanecarboxylic acid, sodium trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylate, ammonium trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid Potassium acid, potassium trans-4-p-bromobenzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-m-chlorobenzyloxycarbo Calcium nylaminomethylcyclohexanecarboxylate, magnesium trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexanecarboxylic acid monoethanolamine, trans-4-t- Butyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- ( 3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) Cyclohexanecarboxylic acid, sodium trans-4-t-butyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylate, trans-4- (p-biphenylisopropyloxycarbonyl) Aminomethyl) calcium cyclohexanecarboxylate, trans-4- (3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) magnesium cyclohexanecarboxylate, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid monoethanolo- Lumine, trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4-methylsulfonylethyloxycarbo Ruaminomethylcyclohexanecarboxylic acid, trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) sodium cyclohexanecarboxylate, potassium trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4- (pyridine -4'-methyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexane Potassium carboxylate, trans-4- (pyridine-4′-methyloxycarbonylaminomethyl) cyclohexanecarboxylate sodium, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexane Potassium sancarboxylate, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylate, etc.), tranexamic acid amide or a salt thereof, and derivatives thereof (trans-4-aminomethylcyclohexanecarbonamide, trans-4 hydrochloride) Aminomethylcyclohexanecarbonamide, Nn-hexyl-trans-4-aminomethylcyclohexanecarbonamide, Nn-hexyl-trans-4-aminomethylcyclohexanecarbonamide hydrochloride, Nn-heptyl-trans-4- Aminomethylcyclohexanecarbonamide, Nn-heptyl-trans-4-aminomethylcyclohexanecarbonamide hydrochloride, Nn-butyl-trans-4-aminomethylcyclohexanecarbonamide N-butyl-trans-4-aminomethylcyclohexanecarbonamide, Nn-propyl-trans-4-aminomethylcyclohexanecarbonamide, N-cyclohexyl-trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N -Cyclohexyl-trans-4-aminomethylcyclohexanecarbonamide, N, N-dicyclohexyl-trans-4-aminomethylcyclohexanecarbonamide, N, N-dicyclohexyl-trans-4-aminomethylcyclohexanecarbonamide hydrochloride, N, N- Diethyl-trans-4-aminomethylcyclohexanecarbonamide, N, N-diethyl-trans-4-aminomethylcyclohexanecarbonamide hydrochloride, N-benzyl-trans-4-aminomethyl Cyclohexanecarbonamide, N-benzyl-trans-4-aminomethylcyclohexanecarbonamide hydrochloride, N- (4'-methoxyphenyl) -trans-4-aminomethylcyclohexanecarbonamide, N- (4'-methoxyphenyl) hydrochloride -Trans-4-aminomethylcyclohexanecarbonamide, N- (4'-ethoxyphenyl) -trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N- (4'-ethoxyphenyl) -trans-4-aminomethylcyclohexanecarboxylic acid Amide, N- (2'-methylphenyl) -trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N- (2'-methylphenyl) -trans-4-aminomethylcyclohexanecarbonamide, N- (3'-methylpheny ) -Trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N- (3'-methylphenyl) -trans-4-aminomethylcyclohexanecarbonamide, N- (4'-chlorophenyl) -trans-4-aminomethylcyclohexanecarboxylic acid Amide, hydrochloric acid N- (4′-chlorophenyl) -trans-4-aminomethylcyclohexanecarbonamide, etc.), sulfatide, astaxanthin fatty acid diester (astaxanthin dilaurate, astaxanthin dimyristate, astaxanthin dipentadecanoate, astaxanthin diester) Palmitic acid ester, Astaxanthin dipalmitooleic acid ester, Astaxanthin diheptadecanoic acid ester, Astaxanthin dieraidic acid ester Astaxanthin diricinoleate, astaxanthin petrolinate, astaxanthin vacsenate, astaxanthin eleostearate, astaxanthin punicinate, astaxanthin licanoate, astaxanthin parinalate, astaxanthin gadorate, astaxanthin 5- Eicosenoic acid ester, astaxanthin 5-docosenic acid ester, astaxanthin cetolic acid ester, astaxanthin erucic acid ester, astaxanthin 5,13-docosadienoic acid ester, astaxanthin ceracholic acid ester, astaxanthin desenic acid ester, astaxanthin steric acid ester, astaxanthin dodecenoic acid Esther, Astaxanthin Diolei Acid esters, astaxanthin distearic acid esters, astaxanthin dieicosapentaenoic acid esters, astaxanthin didocosahexaenoic acid esters, astaxanthin dilinolenic acid esters, astaxanthin dilinolenic acid esters, astaxanthin diarachidonic acid esters, etc.), astaxanthin diglycerophosphates (astaxanthin diesters) Glycerophosphate, Astaxanthing lyserophosphate palmitic acid, Astaxanthing lyserophosphatidylcholine palmitic acid, Astaxanthing lyserophosphatidylcholine DHA, Astaxanthing lyserophosphatidylinositol palmitic acid, Astaxanthing lyserophosphatidylinositol DHA, Astaxanthin Luinositol linoleic acid, astaxanthin lyserophosphatidylcholine linoleic acid, etc., steviol glycosides, benzimidazole derivatives (1- (2-ethoxyethyl) -2- [1- (2- (4- (1- (4 , 4-Dimethyl-2-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- (4- (1- ( 2-Ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoic acid, ethyl 2- [4- (2- (4- (1- (2-ethoxyethyl)) Benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanate, 1- (2-ethoxyethyl) -2- [1- (2- (4- (1,1-dimethyl) -2-hydroxyethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 1- (2-hydroxyethyl) -2- [1- (2- (4- (1- (4,4-Dimethyl-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- ( 4- (1- (2-hydroxyethyl) benzoimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoic acid), alanine derivatives or salts thereof (N- [3-isopentyl- 4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl] -L-alanine, N- [3-isopentyl-4-methyl-2- [4- (3-Trifluoromethylbenzamide) benzoylimino] -3H-thiazoline-5-carbonyl] -2-methylalanine, N- [3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamide) Benzoylimino] -3H-thiazoline-5-carbonyl] -N-methyl-L-alanine), thiazoline derivatives or salts thereof (3-isopenes) Ru-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid, 4-isobutyl-3-methyl-2- [4- (3-trifluoro Methylbenzamide) benzoylimino] -3H-thiazoline-5-carboxylic acid, etc.), chlorpheniramine maleate, diphenhydramine hydrochloride, diphenylpyraline hydrochloride, carbinoxamine maleate, hydrocortisone butyrate, sulfated acidic mucopolysaccharides or salts thereof, sulfated Dextran or its salt, Fluoromethylhistidine or its hydrochloride, Histidine methyl ester or its hydrochloride, Licorice extract, Shikon extract, Ages extract, Propolis, Eye (Aiba) extract, Asenyaku (Asenyaku) extract, Avocado extract, Amadokoro Bamboo) extract, Amiga lily extract, Baimo (shellfish mother) extract, Igakouzo Na extract, Ibukitorano extract, Turmeric extract, Echinashi pear extract, Oren extract, Ogulma extract, Hypericum extract, Orange extract, Orange extract , Cassia extract, chamomile extract (weed) extract, kawamidori extract, kawarayomogi (bamboo chin mackerel) extract, watercress extract, kenshi sartorii rose (bamboo shoot, mountain return) extract, gentian extract, koki sekku extract, kakuhon (bamboo shoots, tang bonito) extract, cucumber Kyo (Koryo strawberry) extract, Gosho strawberry (covered bonsai) extract, Sai Hailan extract, Cherry extract, Salvia (Sage) extract, Diquitaris extract, Linden extract, Salamander extract, Indobodai extract, Shukushamitsu ( (Sand, reduced sand) extract, juzudama extract, shirominanten (southern berry extract), ivy extract, sunflower extract, yarrow extract (milfoil) extract, broadleaf extract, takasagorihigotai extract, takaharabi extract , Tachikaku (Marika) extract, Tamazaki tsuji rafuji extract, Tonin extract, Chigaya extract, Toga (winter coconut) extract, Dokudami (10 medicines) extract, Parsley (Dutch jelly) extract, Hamabishi (Sitoshi, Shishitsuri) extract, Hamasuge ) Extract, Hishi (Rhizomi) extract, Bellows oyster extract, Prunus quail extract (South rattan) extract, Bundou (mung bean) extract, Sandalwood extract, Butcher bloom extract, Pansy extract, Hosoba-Aragiku extract Tennansho extract, pheasant extract, miracle fruit extract, mussel extract, peach (peach) extract, cornflower extract, yachiyanagi extract, mistletoe (willow parasite) extract, yabukouji (purple gold beef) extract, wormwood extract , Artemisia (bamboo leaf) extract, Rosemary (Mannenrou) extract, Itohimehagi extract, Jujuzumo extract, Tamajuzumo extract, Mizojusummo extract, Urushigusa extract, Siwahige extract, Akamok extract, Togemoku extract, Akaba extract, Maruba akaba extract , Spinach extract, dulse extract, una extract, belladonna extract, cypress extract, harimille (crustacean, cinnamon bark, birch leaf) extract, Aozulan extract, sakaneran extract, sasabagin orchid, varieties and origin species Including) extract, Kanoko Saw extract, evening primrose extract, Sen Qiu extract, apricot kernel extract, honeysuckle extract, Japanese angelica root extract, fennel extract, peppermint extract, and the like.

Anti-seborrheic agent An anti-seborrheic agent can be added to the present invention. Specific examples of the antiseborrheic agent include chroman derivatives, pyridoxine or salts thereof and derivatives thereof, pyridoxal or salts thereof and derivatives thereof, pyridoxamine or salts thereof and derivatives thereof, sulfur, Asa extract, (Continuous) extract, Dutch mustard (watercress) extract, valerian extract (valerian root) extract, clematis extract, bear sebacekis, savonso extract, rosewood extract, horse chestnut extract, soybean (soybean) extract, milkflower extract (marigold) extract, Chinese yam Examples include extracts, yam extract, nosenhalen extract, dandelion poppy (sect winter flower, winter winter leaf) extract, japonica extract, giant kelp extract, hijirimen extract, primrose extract, haius banori extract and the like.

Antibacterial Agent An antibacterial agent can be added to the present invention. Specific examples of antibacterial agents include acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salashi powder , Iodine compounds, iodoform, 1-alkylcarbapenem compounds, N-substituted azepane derivatives or salts thereof, sorbic acid or salts thereof, propionic acid or salts thereof, salicylic acid or salts thereof, dehydroacetic acid, parahydroxybenzoic acid esters, 2 -Keto-3-deoxyoctanoic acid fatty acid esters, inositol deoxy derivatives (such as quercitol), inositol unsaturated derivatives (such as chonditol), inositol dimethyl ether, methyl inositol, inositol Ether, inosamine, deoxyinosadiamine, shikimic acid, quinic acid, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol , Thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, Chlorobutanol, isopropylmethylphenol, elemol, vetiverol, patchouli alcohol, nonionic surfactant (polyoxyethylene lauryl ether, polyoxyethylene nonyl) Phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride) , Methylrosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal violet, germal, photosensitive element 101, photosensitive element 201, photosensitive element 401, N-long chain acyl basic amino acid derivative and acid addition salt thereof, Zinc oxide, hinokitiol, propolis, cucumber extract, agi extract, asunaro extract, alpinia extract, katsudai (suzukuku) extract, Inubiyu extract, Aogate Extract, Haribiyu extract, Ayuyu extract, Hagatetou extract, Hosonagabiyu extract, Enmeiso extract, Warbler extract, Usubasaicin extract, Oshusaishin extract, Halibut extract, Ominaeshi (losing soy sauce) extract, Kajikazura鈎) Extract, Kahoku Salamander (蜀椒) Extract, Chamomile Extract, Kinakiki Extract, Red linden Extract, Yellow Spider Extract, Caraway Extract, Betel Extract, Kumazasa Extract, Cranberry Extract, Grapefruit Extract, Celosia (Chick Crown Flower, Chicken Crown) ) Extract, bay bay laurel extract, cinnabar rose (moon flower) extract, copaiba balsam extract, wild cherry extract, ed pear extract, Miyaza cherry extract, Yoshino cherry extract, Kazumi cherry extract, kanzaku La extract, sugar beet extract, white pepper extract, cicada extract, birch extract, cinnamon extract, sorrel extract Extract, Sowka (grass) extract, onion extract, chicory extract, Korean senile (蕪 夷) extract, tsuruna (apricot) extract, tokon (root) extract, leek (yuzu) extract, leek extract, leek extract, patchouli Extract, Japanese anemone extract (Ishibuchi, Bujushahua) extract, Japanese cypress extract, Pimenta extract, White-bellied clover (Bald eagle) extract, Blackberry extract, Hop extract, Makuri (Seaman grass) extract, Magnolia sprengeri extract, Mizokakushi ( Hanbe extract), Honey bee , Murasaki (purple root) extract, Moso bamboo extract, pokeweed (commercial land) extract, Yucca extract, Eurasian rush extract, lavender extract, Forsythia extract, Sylar Forsythia extract, Obatsunomata extract, Tochaka (Yahazutsu no Mata) extract, Akamominori Extract, Anaaasa Extract, Human Rabbit Extract, Hirohanohito Exa Extract, Ushito Rabbit Extract, Iroro Extract, Ishige Extract, Arame Extract, Tamai Taki Extract, Tambanori Extract, Kata Nori Extract, Sakuranori Extract, Fuji Matsumo Extract, Kawamokuzuku Extract, Akakawa Mozuku Extract And Yakuchi extract.

Blood flow promoter / vascular stimulator A blood flow promoter / vascular stimulator can be added to the present invention. Specific examples of blood flow promoters and vascular stimulants include tocopherol or salts thereof and derivatives thereof, tocotrienol or salts thereof and derivatives thereof, cephalanthin, carpronium chloride, eugenol derivatives (acetyl eugenol, methyl eugenol, methyl isoeugenol, ethyl Eugenol, ethylisoeugenol, eugenol salicylate, etc.), minoxidil, chili pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, L-menthol, camphor, benzyl nicotinate, cinnarizine, trazoline, acetylcholine, verapamil, ectamol , Α-borneol, cyclandelate, nonyl acid wallenylamide, capsaicin, gingerone, assembly extract, garlic extract, carrot , Aloe extract, gentian extract, touki extract, ashitaba (tomorrow leaf) extract, arnica extract, ukiyagara (three ridges) extract, himeuki sakura extract, shrimp mandarin (chonse) extract, toucan extract (coconut) extract, oyster extract, cocoon extract , Kina extract, Ginseng extract, Anemone extract, Gubijinsou extract, Kouhone (river bone) extract, Burdock (beef bowl, beef coconut) extract, Sagaki (Yellow root) extract, Chinese syringa extract, Ginger (ginger) extract , Shobu extract, Japanese hawthorn extract, Seburi extract, Daidai extract, Tanjin extract, Thyme extract, Chikutsujinjin (Takebushi ginseng) extract, Tsurudokudami Extract, Carrot (Yotsu-san) Extract, Capsicum (Banban) Extract, Toki (Toki) Extract, Shiromumochi (Female Sadako) Extract, Natsumikan Extract, Elderberry (Bonegrass) Extract, Hazel (Zushi) Extract, Hashiridokoro (Roto Root) Extract, Pepper (Light Pack) , Light leaf) extract, Hamabou Fu (hama breeze) extract, Higotai extract, Fujimodoki (Chojizakura, Camellia flower) extract, black currant extract, Bodaiju extract, Merilot extract, Yuzu extract, Loby extract, bay jelly extract, Hibiscus Extract, rosehip extract and the like.

Antiandrogen Agent An antiandrogen agent can be added to the present invention. Specific examples of antiandrogens include follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendron, 4 ', 5,7-trihydroxy-8-prenylflavanone, 4', 5,7-trihydroxy-8 -Prenyl flavone, 3,3 ′, 4 ′, 5,7-pentahydroxy-8-prenyl flavone, nicorandil, cyclosporine and the like.

Structural proteolytic enzymes (matrix metalloproteases such as elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme) activity inhibitor / structural protein Decomposition enzyme expression inhibitor The present invention includes a matrix of structural proteolytic enzymes (elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme, etc. A metalloprotease) activity inhibitor / structural protease inhibitor can be added. Specific examples of structural protease inhibitors) and structural protease inhibitors include adenine derivatives (butanetriol-9-adenine and its phosphate adduct, propanediol-9-adenine and its phosphate adduct, Pentanetriol-9-adenine and its phosphate adducts), carbostyril derivatives or salts thereof, dicarboxylic acids (glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, 1,9-nonamethylenedicarboxylic acid) Acid, 1,10-decamethylenedicarboxylic acid), rosmarinic acid, ursolic acid, oleanolic acid, hydroxamic acid derivative, esculetin derivative, anthocyanidins, nordihydroguaiaretech acid, 20-carboxy-16-hydroxy-21-nor- Five
α-7,9 (11) -lanostadien-3,24-dione, ubiquinone, plastaquinone, yuglone, shikonin, quinizarin, alizarin, abietin, levopimaric acid, betulin, α-amylin, catechin compounds (catechin, epigallocatechin, Epigallocatechin gallate, epicatechin, epicatechin gallate, catechin rhamnopyranoside catechin, etc.), diisopropyl fluorophosphate, (2R, 6R) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)- (3Z) -Heptene-1,7-dicarboxylate dimethyl, N, N'-bis-[(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyl Oxy-4-hydroxyheptanedicarboxylic acid-1,7-diamide, (2R, 6R) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid dimethyl, (2R, 6R) -2,6-Dibenzyloxy-4- tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1 , 7-Dicarboxylic acid diamide, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydroxyheptane-1 , 7-Dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,4,6-trihydroxyheptane-1,7- Dicarboxylic acid diamide, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2,6-dibenzyloxy-4-hydroxyheptane-1,7- Dicarboxylic acid diamide, (2S, 6S) -2,6-dihydroxy-4- (tert-butyldimethyl) Ryloxy)-(3Z) -heptene-1,7-dicarboxylate, (2S, 6S) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, ( 2S, 6S) -2,6-Dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2S, 6S) -2,6-dibenzyloxy-4- ( tert-Butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2,6-di Benzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R ) -2,6-Dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, 3-[[4- (4-fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclopentyl) ) -Amino] -propionic acid, 4- [4- (4-fluorophenoxy) -benzenesulfonylamino] -tetrahydropyran-4-carboxylic acid hydroxyamide, 4- [4- (4-chlorophenoxy) -benzenesulfonylmethyl ] -Tetrahydropyran-4-carboxylic acid hydroxyamide, 3-[[4- (4-fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclobutyl) -amino] -propionic acid, 4- (4'- Chlorobiphenyl-4-yl) -2- [2- (1,3-dioxo-1,3-dihydroisoindol-2-yl) -ethyl] -4-oxobutyric acid, 1- [4- (4-fluoro Benzyloxy) -benzenesulfonyl] -2-hydroxycarbamoylpiperidin-3-yl) -carbamic acid isopropyl ester, 2- [4- (4-fluorophenoxy) -benzenesulfonylamino] -N-hydroxy-2-methylpropionamide , 3- [4- (4-Fluorofluoro Noxy) -benzenesulfonyl] -2, N-dihydroxypropionamide, 3- (4-phenoxybenzenesulfonyl) -7-oxabicyclo [2.2.1] heptane-2-carboxylic acid hydroxyamide, (4-benzylbenzyl)- [2- (2,2-Dimethyl-1-methylcarbamoylpropylcarbamoyl) -4- (4′-fluorobiphenyl-4-yl) -butyl] -phosphinic acid, 2-amino-3- [4- (4- Fluorophenoxy) -Benzenesulfonyl] -N-hydroxypropionamide, N-hydroxy-2- (4-phenylpiperidine-1-sulfonyl) -acetamide, Oenothera extract, Nematode extract (Summer hay) extract, Prunus vulgaris extract , Hawthorn extract, hawthorn extract, carahoe extract, guava extract, trash extract, ginger extract, chilli Extract, Hypericum perforatum extract, Jacobe (breeding) extract, Hinata Taikozuchi (cow knee) extract, Honoki (Japanese Koshoku, Park) extract, American grape extract, European grape extract, Yama grape extract, Mandarin extract, Mishima psycho (Shibako) extract , Ogon extract, Hypericum extract, Clara extract, Mulberry extract, Cinnamon extract, Gentian pepper extract, Comfrey extract, Salvia extract, Horseshoe extract, Bodge extract, Button pi extract, Aozuran extract, Sakaneran extract, Sasabagin orchid extract And an origin species) extract, Aonorus agave extract, sisal extract, garlic extract and the like.

Structural protein synthesis promoter A structural protein synthesis promoter can be added to the present invention. Specific examples of the structural protein synthesis accelerator include ethanolamine derivatives, pentoxyphyllin, serine derivatives, geraniol, crocetin, methyl 4- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-4- (3, 5,5-Trimethylhexyloxy) methyl benzoate, methyl 4-cyclohexylmethoxy-2-hydroxybenzoate, methyl 4- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4- (3,7-dimethyl-6 -Octenyloxy) methyl 2-hydroxybenzoate, ethyl 3- (2-ethylhexyloxy) -5-hydroxybenzoate, methyl 5- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-5 -(3,5,5-trimethylhexyloxy) methyl benzoate, methyl 5- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4-N-hexyloxy-2-hydroxy Methyl benzoate, methyl 2-hydroxy-4-N-octyloxybenzoate, methyl 4-N-decyloxy-2-hydroxybenzoate, methyl 5-N-hexyloxy-2-hydroxybenzoate, 4- (2 -Ethylhexyloxy) -2-hydroxybenzoic acid, 2-hydroxy-4- (2,5,5-trimethylhexyloxy) benzoic acid, 4-cyclohexylmethoxy-2-hydroxybenzoic acid, 4- (2-cyclohexylethoxy) 2-hydroxybenzoic acid, 4- (3,7-dimethyl-6-octenyloxy) -2-hydroxybenzoic acid, 3- (2-ethylhexyloxy) -5-hydroxybenzoic acid, 5- (2-ethylhexyl) Oxy) -2-hydroxybenzoic acid, 5- (2-ethylhexyloxy) -2-hydroxybenzoic acid, 2-hydroxy-5- (3,5,5-trimethylhexyloxy) benzoic acid, 5- (2-cyclohexyl) Ethoxy) -2-hydroxybenzoic acid, 4-N-hexyl Xyl-2-hydroxybenzoic acid, 5-N-hexyloxy-2-hydroxybenzoic acid, 2-hydroxy-4-N-octyloxybenzoic acid, 4-N-decyloxy-2-hydroxybenzoic acid, N- (2 -Hydroxyethyl) -4- (2-ethylhexyloxy) -2-hydroxybenzamide, N-ethyl-4- (2-ethylhexyloxy) -2-hydroxybenzamide, 2-acetoxy-4-cyclohexylmethoxybenzoic acid, 4- Sodium (2-ethylhexyloxy) -2-hydroxybenzoate, methyl 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoate, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoate, 5-[(2E) -3,7 dimethyl-2,6-octadienyloxy] -2-hydroxybenzoate Ethyl 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoate, 3- [ 2E) -3,7-dimethyl-2,6-octadienyloxy] -5-hydroxybenzoate, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -3 Ethyl 4-methoxybenzoate, methyl 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzoate, 4-[(2E) -3 , 7-Dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid (2E) -3,7-dimethyl-2,6-octadienyl, 4-[(2E) -3,7-dimethyl-2 , 6-Octadienyloxy] -2-hydroxybenzoic acid, 5-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -5-hydroxybenzoic acid Acid, 2-hydroxy-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4-[(2E) -3,7-dimethyl -2,6-octadienyloxy] -3-methoxybenzoic acid, 2-acetoxy-4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, N- (2 -Hydroxyethyl) -4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzamide, 4-[(2E) -3,7-dimethyl-2,6- Octadienylamino] -2-hydroxybenzoic acid, dimethyl-2,6-octadienyloxybenzoic acid, N- (2-hydroxyethyl) -4-[(2E) -3,7-dimethyl-2,6 -Octadienyloxy] -2-hydroxybenzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienylamino] -2-hydroxybenzoic acid, 3-dodecyloxybenzoic acid, 3- (12-hydroxydodecyloxy) benzoic acid, 4-dodecyloxybenzoic acid, 4- (12-hydroxydodecyloxy) benzoic acid, 3- (12-hydroxyoctadecyloxy) benzoic acid, 4- (12-hydroxyoctadede Siloxy) benzoic acid, 3- (11-hydroxyundecyloxy) benzoic acid, 4- (11-hydroxyundecyloxy) benzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadi Enyloxy] benzoic acid, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, 3-[(2E, 6E) -3,7,11-trimethyl-2, 6,10-dodecatrienyloxy] benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4- [3,7- Dimethyl-9- (2,6,6-trimethyl-1-cyclohexen-1-yl) -2,4,6,8-nonatetraenyloxy] benzoic acid, 4- [3,4-dihydro-2,5 , 7,8-Tetramethyl-2- (4,8,12-trimethyltridecyl) -2H-1-benzopyran-6-oxy] benzoic acid, 4-[(2E, 6E) -3,7,11- Trimethyl-2,6,10-dodecatrienyloxy] benzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzamide, 4- (2-methyl-2-bu Tenenyloxy) benzamide, 4- (2-ethylhexyloxy) benzamide, 4-dodecyloxybenzamide, 4- (12-hydroxydodecyloxy) benzamide, 4- (12-hydroxyoctadecyloxy) benzamide, 4- (11-hydroxyundecyl) Oxy) benzamide, 4- (10-hydroxydecyloxy) benzamide, 4-isostearyloxybenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2, 6,10-dodecatrienyloxy] benzamide, N, N-dimethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzamide, N, N -Di [(2E) -3,7-dimethyl-2,6-octadienyl] -4-aminobenzamide, 4- [N'-methoxycarbonyl-N-[(2E) -3,7-dimethyl-2,6 -Octadienylamino] benzamide, 4- [N-acetyl-N-[(2E) -3,7-dimethyl-2,6-oct Dienyl]] aminobenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, N , N-diethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, pea extract, Tosakamodoki extract, Ikanoashi extract, Hosoibo Nori Extract, Novonori Extract, Igis Extract, Keigi Extract, Harigi Extract, Hanegisu Extract, Usuba Watanagi Extract, Moray Togusa Extract, Fuyugusa Extract, Willow Willow Extract, Willow Tree Extract, Moyuyurena Extract, Vulgaris Extract, Mosayanagi Examples include extract, Sasabayana chinori extract, wasabi extract, merbou extract and the like.

Mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitor A mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitor can be added to the present invention. Specific examples of mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitors include anacardic acid or derivatives thereof (6-pentadecatrienylsalicylic acid methyl ether, 6-pentadecatrienylsalicylic acid ethyl ether, 6-pentadeca Trienyl salicylic acid propyl ether, 6-pentadecatrienyl salicylic acid butyl ether, 6-pentadecatrienyl salicyl alcohol methyl ether, 6-pentadecatrienyl salicyl alcohol ethyl ether, 6-pentadecatrienyl salicyl alcohol propyl ether, 6- Pentadecatrienyl salicyl alcohol butyl ether, 6-pentadecatrienyl salicylaldehyde methyl ether, 6-pentadecatrienyl salicylaldehyde ethyl ether, 6-pentadecatrienyl salicyl aldehyde Hydropropyl ether, 6-pentadecatrienyl salicylaldehyde butyl ether, 2-methyl ether-6-pentadecatrienyl cinnamic acid, 2-ethyl ether-6-pentadecatrienyl cinnamic acid, 2-propyl ether-6 -Pentadecatrienyl cinnamate, 2-butyl ether-6-pentadecatrienyl cinnamate, 2-methyl ether-6-pentadecatrienyl cinnamate alcohol, 2-ethyl ether-6-pentadecatrienyl cinnamate Skin alcohol, 2-propyl ether-6-pentadecatrienyl cinnamon alcohol, 2-butyl ether-6-pentadecatrienyl] cinnamon alcohol), polyisoprenylated benzophenone derivatives (garcinol, isogarcinol, xantho) Thymol, isoxanthothymol, gucciferon, etc.), Ikarisou extract, Yachima Taikiso Inyo-kaku extract, Narco lily extract, Snapper extract, Yellow orchid extract, Oshida extract, Onji extract, Spruce extract, Crow birch extract (half-summer) extract, pheasant extract Skin) extract, goshuyu extract, senega extract, sendan extract, tamarind extract, tarragon extract, ginkgo biloba extract, bee extract, daisy extract, mirabaran extract, himebara extract, Mockin Extract, Laurel Extract, Yab Cycad Extract, Anaaaosa Extract, Macrocystis Integrifolia Extract, Neocities Ruetkeana Extract, Nettle Extract, Pterosa Extract, Kata Duck Extract, Yatabegusa Extract, Primrose extract, Ezotsunomata extract, Totsunomata extract, Fusaiwata mushroom extract, Hanemo extract, Mill extract, Chromel extract, Nagamil extract, Hiramil extract, Matsumo extract, Okinawa mozuku extract, Mozuku extract, Fukuronori extract, Kajime extract, Fukurofunori extract, Makuhori extract, grape leaves Examples include extracts, salamander extracts, and astragalus extract.

Mucopolysaccharide synthesis promoter A mucopolysaccharide synthesis promoter can be added to the present invention. Specific examples of mucopolysaccharide synthesis promoters include stilbene derivatives or salts thereof, morgin or salts thereof and derivatives thereof, N-acetylglucosamine, flax extract, cinnamon extract, mulberry extract, scotch extract, breadfruit extract, hirakotoji extract , Kotojitsu no Mata Extract, Yaleus Banori Extract, Kagiosu Banori Extract, Susius Banori Extract, Amiaosa Extract, Nagaaosa Extract, Hosobanosakamodoki Extract, Hirohatosakamodoki Extract, Yatsudegatatosakamodoki Extract, Kurotosakamodoki Examples include extract, Nezushinosakamodoki extract, Yusora extract, Etsukinotosakamodoki extract, Nankaitosakamodoki extract, Himetosakamodoki extract, and the like.

Intercellular lipid production promoter / intercellular lipid state improver An intercellular lipid production promoter / intercellular lipid state improver can be added to the present invention. Specific examples of intercellular adipogenesis promoters and intercellular lipid state improvers include phospholipids (phosphatidylethanol, phosphatidylcholine, phosphatidyltriethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylglycerin, phosphatidylinositol, diacylphosphatidylcholine, diacylphosphatidylethanol Amine, diacylphosphatidylinositol, diacylphosphatidylserine, 1-cysteinylphosphatidic acid, 2-cysteinylphosphatidic acid, 1-glutathionylphosphatidic acid, 2-glutathionylphosphatidic acid, 1-azelaoylphosphatidic acid, 2- Azela oil phosphatidic acid, 1-hydroxyacyl phosphatidic acid, 2-hydroxyacyl phosphatidic acid, ceramide, glucosyl Ceramide, Galactosylceramide, Cerebroside, Phosphatidylglucosylacylglycerol, N-oleoylsphingosine, N- (12-hydroxyoctadecanoyl) sphingosine, N- (16-hydroxyhexadecanoyl) sphingosine, N-salicyloylphytosphingosine, Sphingomyelin, soybean lecithin, egg yolk lecithin, etc.), sterins (cholesterol, dihydrocholesterol, cholesteryl stearate, cholesteryl hydroxystearate, macadamia nut oil fatty acid cholesteryl, β-sitosterol, stigmasterol, campesterol, ergosterol, 5-dihydro Ergosterol, phytosterol, 25-hydroxycholesterol, 26-hydroxycholesterol, 19-hydroxycholesterol, 22-ke Tocholesterol oxime, 6-ketocholesterol and 7-ketocholesterol or their derivatives), N-acetylneuraminic acid (sialic acid), N-glucosolneuraminic acid, gangliosides (gangliotriose, gangliotetra Ose, globotetraose, neolactotetraose, neolactohexaose, neolactooctaose, etc.), oligosulfated hyaluronic acid, hydroxytamoxifen compounds, glyceroglycolipids, pentoxyphyllin, 3-deazaadenosine, carboxamide derivatives , Inositol polyamines, Sialic acid, Triterpenic acid derivatives, Lactose, Lactosamine derivatives, Sulfated chitin derivatives, Albumin, Panax ginseng extract, Tochiban ginseng extract, Tiger lily extract, Sasayuri extract, Hakata Yurieki And dairy extract.

Keratin solubilizer and stratum corneum peeling accelerator A keratolytic agent and stratum corneum peeling accelerator can be added to the present invention. Specific examples of keratolytic agents and stratum corneum exfoliation accelerators include tropolone and its derivatives, resorcin, lactic acid, urea, salicylic acid, guanidine, ethanolamine, kikarasuuri extract, fenugreek extract, wisteria bean extract, and lentil extract. Chickpea extract, mungbean extract and the like.

Plasminogen activator antagonist inhibitor A plasminogen activator antagonist inhibitor can be added to the present invention. Specific examples of the plasminogen activator antagonist inhibitor include rabbit daisy extract, canamgra extract, caladium extract, raspberry extract and the like.

Maillard reaction inhibitor A Maillard reaction inhibitor may be added to the present invention. Specific examples of Maillard reaction inhibitors include aminoguanidine, flavanones (naringin, naringenin, liquiritin, liquiritigenin, digallic acid, luteoic acid, ellagic acid, chlorogenic acid, glucogallin, tetralin, hamamelitannin, gallic tannin, tannic acid, Geraniin, gallic acid, galloyl gallic acid, ellagitannin, hexagalloyl glucose, heptagalloyl glucose, tetragalloyl glucose, trigalloyl glucose, pentagalloyl glucose, digalloyl quinic acid, trigalloyl quinic acid), 2-hydroxyphenylalkylamine Derivatives or salts thereof, phenylpropenoic acid derivatives (3- [2,3-bis (methoxymethoxy) phenyl] propenoic acid, 7- (4-hydroxy-3-methoxyphenyl) hepta-2,4,6-trienoic acid, 3- (3,5-dimension Xyl-4-hydroxyphenyl) propenohydrazide, N'-isopropylidene-3- (2-methoxyphenyl) propenohydrazide, etc.), citric acid or its salts, gypsum extract, sandalwood extract, akamegasiwa extract , Persimmon (including persimmon) extract, mulberry extract, Hypericum perforatum extract, camellia extract, garrega extract, yaba santa extract, rose hip extract, asunaro extract, itadori extract, yakuya extract, caeca extract, birch extract, hawthorn extract, Achillea millefolium extract, cod extract, tortilla extract, tortilla extract, buckwheat extract, hiba extract, grape extract, red willow extract, mugwort extract, karin extract, mokka extract, Roman chamomile extract, etc. I can get lost.

Testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promoter A testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promoter can be added to the present invention. Specific examples of testosterone 5α reductase activity inhibitor, hair papilla activator and hair growth promoter include γ-amino-β-hydroxybutyric acid esters (γ-amino-β-hydroxybutyric acid methyl ester, γ-amino-β- Hydroxybutyric acid ethyl ester, γ-amino-β-hydroxybutyric acid propyl ester, γ-amino-β-hydroxybutyric acid butyl ester, γ-amino-β-hydroxybutyric acid ethylhexyl ester, γ-amino-β-hydroxybutyric acid hexadecyl ester, γ-amino-β-hydroxybutyric acid lauryl ester, γ-amino-β-hydroxybutyric acid stearyl ester, γ-amino-β-hydroxybutyric acid oleyl ester, γ-amino-β-hydroxybutyric acid benzyl ester, γ-amino-β- Hydroxybutyric acid phenyl ester, γ-amino-β-hydroxybutyric acid ethyl glycol ester, γ-amino-β-hydroxy Butyric acid sorbitol ester, γ-amino-β-hydroxybutyric acid polyoxyethylene glycol ester, γ-amino-β-hydroxybutyric acid glycerin ester, etc.), amine oxides (oleyl dimethylamine oxide, stearyl dimethylamine oxide, palmityl dimethylamine oxide) , Myristyl dimethylamine oxide, lauryl dimethylamine oxide, dimethyl lauryl ethoxyamine oxide, dihydroxyethyl lauryl amine oxide, coconut oil alkyl dimethylamine oxide, etc.), alkyl betaines (coconut oil fatty acid amide propyl betaine, coconut oil alkyl betaine, lauryl dimethyl) Aminoacetic acid betaine, lauric acid amidopropyl betaine, lauryl hydroxysulfobetaine, 2-alkyl-N-carboxymethyl-N-hydroxy Cyethyl imidazolinium betaine), pyrimidine-N-oxide derivatives (2-amino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-6- (1-pyrrolidinyl) Pyrimidine-3-oxide, 2-amino-4-methyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-6- [1- (4-methylpiperazinyl)] pyrimidine-3- Oxide, 2-amino-4- (1-hexahydroazepinyl) -6-methylpyrimidine-1-oxide, 2-amino-4-dimethylamino-6-methylpyrimidine-1-oxide, 2-amino-4 -Allylamino-6-methylpyrimidine-1-oxide, 2-amino-4-benzylamino-6-methylpyrimidine-1-oxide, 2-amino-4,5-methyl-6-piperidinopyrimidine-3-oxide 2-amino-4-ethyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-5-nitro-6-piperidinopyrimidine-3-oxy Sid, 2,5-diamino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino -4-methyl-5-piperidino-6- (1-pyrrolidinyl) pyrimidine-3-oxide, 2-methyl-4-amino-6-piperidinopyrimidine-3-oxide, 2-methyl-4-amino-5 -Bromo-6- (1-pyrrolidinyl) pyrimidine-3-oxide, 2-methyl-4-amino-5-nitro-6-piperidinopyrimidine-3-oxide, 2-methyl-4,5-diamino-6 -Piperidinopyrimidine-3-oxide, 2-methyl-4-amino-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-6-piperidinopyrimidine-3 -Oxide monohydrochloride, 2-acetylamino-4-methyl-6-piperidinopyrimidine-3-oxide, 2,4-diamino-6-phenoxypyrimidine-3-oxide, 2,4-diamino-6- ( 2,4-dichloropheno C) Pyrimidine-3-oxide, 2,4-diamino-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitroso-6- (2,4-dichloro) Phenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2 , 4-Dichlorophenoxy) pyrimidine-3-oxide, 2,4,5-triamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-bromo-6- (2 , 4-dichlorophenoxy) pyrimidine-3-oxide, etc.), p-menthane-3,8-diol, monoglyceryl-D-glucoside monotridecanoate, 1-oN-pentadecylglycero-D-glucoside, Glyceride sulfate such as monopentadecanoic acid glyceride sulfate, monopentadecyl glyceryl ether sulfate, 1-o-hexa Decyl-2-o-methylglycerin, 1-o-octadecyl-2-o-methylglycerin, 1-o-oleyl-2-o-methylglycerin, acetylcarnitine or its salt, geranylgeranylacetone, hydroxamic acid derivative or its salt , Gingerone glycosides, benzeneoxyacetic acid derivatives ([5- [2- [1-phenyl-1- (3-pyridyl) methylideneaminooxy] ethyl] -7,8-dihydronaphthalen-1-yloxy] acetic acid, etc. ), Isorhamnetin-3-robinobioside, xanthone derivatives, proanthocyanidins (grape seed extract proanthocyanidins, apple-derived proanthocyanidins, pine-derived proanthocyanidins, purified procyanidin oligomers, procyanidin B-2, procyanidins B-2, procyanidins B-3 , Procyanidin C-1 etc.), arakashi extract, angelica extract, apricot , Hong anzu extract, Ichiyakusou (one medicinal herb) extract, Enishida extract, psyllium (carlet child, car forerunner) extract, Psyllium extract Striped anteater extract, ginseng extract, scallop extract, cucumber nut extract, camphor extract, kubeba extract, buckthorn extract, oyster extract ) Extract, Sanekazura extract, Vinankazura extract, Matsubusa extract, Colombo extract, Condurango extract, Sasanqua extract, Sweet potato extract, Sanebutona Mei (acid soy sauce) extract, Sandskon (Yamazu-root) extract, Potato extract, Shishigashira extract, Sanshishi extract, Coriander extract, Stevia extract, Takatodai extract (Daisen) extract, Tarayo (Oba winter blue, Ichiha tea, bitter tea, bitter lantern Tea) extract, taranum extract, oyster tree extract, nullde (penta) extract, Hakama Labosi (bone crushing) extract, spider crab extract, scented squirrel extract, stag beetle extract, boxweed extract (rice plant) extract, lizard carrot ( Participant) extract, mangosteen extract, myoga extract, melaroika extract, jachabushi extract, himeya sabushi extract, oyabe sabushi extract, yakuso extract, yamanookiki (yamabeki) extract, longan (long-eye meat) extract, locon (reed, reed) extract, Logwood Ex And lantana extract.

Hair matrix growth inhibitor / hair growth inhibitor A hair matrix growth inhibitor / hair growth inhibitor may be added to the present invention. Specific examples of hair matrix growth inhibitor / hair growth inhibitor include phthalazinones, benzoxazinones, phosphonic acid derivatives, cyproterone, 5α-androstene-3α, 17β-diol, medroxyprogesterone, norethisterone, methanolone, and ichihatsu (First) extract, ash extract, kanto extract, sangiko extract, silamo extract, sardine extract, scabbard fern extract, fritillary extract, honeysuckle extract, seaweed extract, yoremok extract and the like.

Hair swelling agent / hair protecting agent A hair swelling agent / hair protecting agent can be added to the present invention. Specific examples of the hair swelling agent / hair protecting agent include ethanolamine, urea, guanidine, silicones, blueberry extract, mango extract and the like.

Odorous substance eliminating agent An odorous substance eliminating agent can be added to the present invention. Specific examples of the odorous substance eliminating agent include Inondo extract, Elemi extract, vanilla bins extract, pine extract and the like.

Other Additive Ingredients Specific examples of ingredients derived from plant-based materials used as additives to the present invention include Aokazura (Seifu Fuji) extract, Aotenma extract, Akasuguri extract, Aquine (crust) extract, Aguay Guasu extract, Abiyu extract, Abiurana extract, Yellow sapote extract, Ylang ylang extract, phalaenopsis extract, Uba tea extract, Ezo suzuran extract, Unboku extract, Elderberry extract, Ohisano Yuki extract, Sasa no Yuki extract, Toucan cactus extract, Omiya catechu extract, Onoelan extract, Crab extract, Karaya extract, Garyu extract, Kawaratake extract, Candelilla extract, Canna extract, Kidachi pepper extract, Kimenkaku extract, Cabb extract, Kiraja saponaria extract, Ginseca Extract, kimbsen extract, guapeba vermelha extract, kugenumaran extract, gooseberry extract, crity river extract, curcrigo latifolia extract, black moth (rescue) extract, cucumber extract, sapotea mariyo extract, salmon berry extract, salamander extract , Cactus Cactus Extract, Cranberry Extract, Shunran Extract, Shozuk Extract, Shirobanatsuta Extract, Cinchona Sacylbra Extract, Swimberry Extract, Star Apple Extract, Sulgaran (Oran) Extract, Scots Pine Extract, Plexus Japanese butterfly extract, mistletoe extract, sennin cactus extract, senboku extract, elephant shoot extract, prunus extract, somamonoimoe , Dark sweet cherry extract, prickly pear extract, chocolate nostay extract, ginseng extract, tsukusa kaneran extract, tsuchiakebi extract, duckweed extract, duberry extract, red squirrel extract, tragacanth extract, triacan Sos extract, Neiseria berry extract, Rapeseed extract, Plover-dough extract, Pau-dose extract, Hakuru berry extract, Batata extract, Hamakakiran extract, Balata extract, Harcan orchid extract, Pecan nut extract, Chicknut extract , Brazilian carrot extract, Branjen extract, Frucereria extract, Blond psyllium extract, Hetsukaran extract, Henken extract, Berry extract, Persea extract, Pervianburg extract, Perez Kia Grandifolia extract, Boysenberry extract, Hosairan extract, Pouteria sapota extract, Pouteria rukuma extract, Hosobabarengiku extract, Whataberry berry extract, Masaransuba extract, Masheira de Boyi extract, Matta auryo extract, Mulberry extract , Green sapote extract, purple corn extract, megacansa optica extract, mokukirin extract, maple leaf extract, morero cherry extract, yakawa potato extract, cornflower mint extract, rulitama thisami (urajiro higotai) extract, red currant extract, Examples include plant extracts such as red pitaya extract, lemongrass extract, wax palm extract and logan berry extract.

In addition, as specific examples of components derived from plant-based raw materials used as an additive to the present invention, Dunaliella genus Dunaliella extract, Kuwanomi genus Kuwanomimo extract, Volbox genus genus sunflower extract, Volbox genus Volbox extract, Palmera extract, Yotsumemo extract, Aomido genus Chrysanthemum extract, Vulgaris extract, Hibimidro spp. Genus Black Ivy Extract, Casanori Genus Casanori Extract, Mika Ichiki Extract, Collecaete Extract, Tsutsumi Mimo Extract, Duckweed Genus Duckweed Extract, Sayamidro Extract, Kunshomo Extract Green algae extract such as Sumiremo violet reed extract, Hosimidro extract, Fuchinasimidro extract Genus Isogawara extract, black moth genus black moth extract, mosquito genus mosquito extract, whip squirrel extract, scallop squirrel extract, squirrel squirrel squirrel extract, common squirrel genus extract, common squirrel genus genus Hiranamikurakura extract, Somerna spruce extract, Navarimo spruce extract, Chawomen spruce extract, Nagamatsu Genus Nagamatsumo extract, Niseft mozuku niseft mozuku extract, Futomozuku genus mozuku extract, Kuromo genus kuromo extract, Nisemo genus nisemozuku extract, Ichimegasa Ichimegasa extract, zelkova quail extract, Umibos genus Citrus genus Compositae extract, Haberomodo spp. Extract, genus Cyprus extract, genus genus genus extract, genus turmeric extract, genus chrome extract, chrysanthemum Brown algae extract such as Bucus spp. Milnobeni extract, Konahada spp. Sodegarami Sodegarami Extract, Hirohatamitaki Hirohatamitaki Extract, Tengusa Nambugusa Extract, Tengusa Kohira Extract, Tengusa Yohira Extract, Tengusa Kinukusa Extract, Velvet genus Hibiroudoekisu, Hibiroudo genus Princess cracked wax de extract, Isomumemodoki genus iso Mume beetle extract,
Michiga spruce extract, Ryumonso ryumonsou extract, Ryumonso spp. Genus Etukiikawa no Kawai, Kainokawa no Kainokawa extract, Kaninote no Kanenote extract, Coral spp. Centipede Fudarak extract, Centipede genus Maruba fudarak extract, Chrysanthemum spp. Toki Extract, Kintoki Kintoki Extract, Kintoki Genori Extract, Kintoki Tosaka Pine Extract, Kintoki Tokimatsu Extract, Kintoki Fusikin Toki Extract, Kintoki Genus Extract, Kintoki Nagaga Toki Extract, Kintoki Sumi-kade Extract, Kakito Toba Kintoki extract, Nagaobane spp. , Genus urchinus extract, venus genus venus genus extract, suskabeni genus suskabeni extract, okamugurusa Porcupine extract, Isomocca genus Isomokka extract, Kizinozo genus Kizinoo extract, Isodantsu genus Isodantsu extract, Azobanori genus Azobanori extract, Ogonori genus Mizoogonori extract, Ogonori genus Pleurotus extract, Ogonori genus Fukushinori extract , Tiger beetle genus extract, genus genus genus extract, genus genus genus genus , Ogonori genus Mosaogoori extract, Ogonori genus moth birch extract, Namiiwatake genus Namiiwatake extract, Saimi genus Extract, Saimi genus extract, Ha Sturgeon spruce extract, Black crested genus Black crested ginkgo biloba extract, Rabbit genus Cyprus extract, Spiraea spp. Dwarf genus Suikokonori extract, Hanaedae spp. Ottoweed extract, Egonori Egonori extract, Egonori Futogisu extract, Saeda Saeda extract, Chilemomochii Chimomiji extract Habutenori extract, Conohanori extract, Suzuronori extract, Usubeniususbeni extract, Hasujiginu Hasujiginu extract, Nagakonohori noriagakonohanori extract, Sugijinu Sugiginu extract, Sugiginu genus Atsubasujiginu extract, Heiusbanori spp. Usubanori extract, Hausubanori genus Suisus banori extract, Haiusubanori genus Hausu banori extract, Usubanorimodoki genus Usubanorimodoki extract, Ayanishiki genus Ayanishiki extract, Ayaginu genus Ayaginu extract, Dadia genus Enasidadia extract, Shimadadia genus Isohadia extract Shimadadia extract, Dajimodokidajimodoki extract, Makuri-makuri extract, Hanagusa genus extract, Hanegusa genus extract, Kozanemo genus Zanemo extract, Kozanemo genus Isomurasaki extract, Cozanemo genus Hosokozanemo extract, Himego genus Himegoke extract, Himegoke kurohimegoke extract, Hyodosig genus Chrysanthemum extract, Hyodosig genus Hyodosigusa extract, Hyodosigus genus Isobasio Red algae extract such as gussa extract, genus genus genus genus genus genus, genus genus genus genus, genus genus idekogome extract, genus genus genus extract, genus genus genus genus genus genus genus genus genus genus genus Axal alga extract such as Likunnotumus extract, Flask extract, Chaboflask extract, Tripella extract, Yellow algae extract such as Hikarimo Hikarimo extract Etc.

  Specific examples of ingredients derived from animal materials used as an additive to the present invention include chicken crown extract, cow, pig or human placenta extract, pig or cow stomach, duodenum, intestine, spleen extract or degradation product thereof, cow Or porcine brain tissue extract, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its degradation product or derivatives thereof, silk protein and Degradation products thereof or derivatives thereof, porcine or bovine blood cell protein degradation products (globin peptides), cattle or porcine hemoglobin degradation products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and degradation products thereof Derivatives thereof, skim milk powder and decomposition products thereof or derivatives thereof, lactoferrin or decomposition products thereof, egg component, fish meat Hydrolyzate, nucleic acid-related substance (ribonucleic acid, deoxyribonucleic acid), and the like.

  Specific examples of components derived from microbial raw materials used as additives for the present invention include yeast metabolites, yeast extract extracts, bacterial metabolites, bacterial extract extracts, metabolites such as fungi or mushrooms, actinomycetes metabolites, fungi Or extracts such as mushrooms, actinomycetes extract, natto metabolite, natto extract, rice fermented extract, rice bran (red rice cake, white birch) fermented extract, euglena extract or a decomposed product thereof, or their water-soluble derivatives, raw milk or defatted Examples include lactic acid fermented milk powder.

  Furthermore, any part, cell, tissue, organ, metabolite, etc. derived from a transgenic or cell fusion can be used as the plant, animal or microbial material. Furthermore, it is obtained by culturing cells of any site, cell, tissue, organ, etc., for example, cultured cells derived from each tissue (cultures derived from animals such as fibroblasts, Langerhans cells, macrophages, epidermal cells, hepatocytes, etc.) Cell etc.), undifferentiated cell group, cell group in the middle of differentiation, and their metabolites can also be used.

  Specific examples of ingredients of natural raw materials used as additives include inorganic salts (magnesium chloride, chloride) obtained from seawater such as deep seawater, for example, seawater salt, seawater dried product, Dead Sea or Atlantic Ocean or Pacific Ocean. Potassium etc.), sea mud or mud (Fango), for example, Italian mugo, German fungo, Eifel fungo, Freiburg fungo, etc. Sea mud or mud (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, Manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, natural smectite , Bentonite, hectorite and the like.

  Extracts derived from plant raw materials, animal raw materials, microbial raw materials, and other natural product raw materials used as additives are processed in a conventional manner according to the product type and form to be added (for example, pulverization, milling, Treatment, extraction, decomposition, fermentation or metabolic conversion by microorganisms, fractionation, purification, pressing, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. ) And arbitrarily select from various materials.

  The solvent used for the extraction may be selected in consideration of the intended purpose and type of the product to be provided, or the processing performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isopropanol are used. Lower alcohol such as butanol or hydrous lower alcohol, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1, 3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, 1,2-hexanediol, 1,5-hexanediol, 1,6-hexanediol, pentylene glycol, hexylene glycol, Polyhydric alcohols such as glycerin and polyethylene glycol (molecular weight 100 to 100,000) or hydrous polyhydric alcohols, Various organic solvents such as seton, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, carbon tetrachloride, phenol, toluene, etc., and acids (hydrochloric acid, sulfuric acid, It is desirable to use one or a mixture of two or more selected from nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.). However, when it is not preferable to contain a solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it may be used alone or in any mixture with water. It may be extracted after squeezing.

  Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. The temperature of the solvent can be arbitrarily set in the range of −4 ° C. to 100 ° C., but is preferably around 10 to 40 ° C. from the viewpoint of the stability of the components contained in the raw material. Further, the weight ratio of the solvent to the raw material can be arbitrarily set within the range of, for example, raw material: solvent 4: 1 to 1: 100, and a weight ratio of 1: 1 to 1:10 is particularly preferable.

  Decomposition mainly includes acid decomposition, alkali decomposition, enzyme decomposition, and high-temperature and high-pressure decomposition. In the decomposition with an acid, for example, it is preferable to use an inorganic acid or an organic acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, oxalic acid, hydrogen bromide, perchloric acid, and periodic acid. In the decomposition by alkali, for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, barium hydroxide, sodium carbonate, ammonium carbonate, calcium carbonate, magnesium hydroxide, sodium silicate, etc. are preferably used. In the decomposition with acid or alkali, the concentration, reaction time, reaction temperature, and the like can be arbitrarily set for the target raw material. In the enzymatic degradation, it is preferable to use an enzyme having a function of degrading proteins, polysaccharides, lipids or complexes thereof having an important function particularly with respect to cell structure, tissue structure, etc., for example, aminopeptidase, dipeptidase, dipeptide Peptidyl peptidase, tripeptidyl peptidase, carboxypeptidase, serine protease, trypsin, chymotrypsin, cysteine protease, thiol protease, papain, aspartate endopeptidase, metalloendopeptidase, bromelain, thermolysin, pronase, pepsin, rennin, pan Proteolytic enzymes (proteases) such as creatine, chymopapain, ficin, collagenase, elastase, amylase, takaamylase, cellulase, hemicellular Polysaccharide-degrading enzymes such as zectin, pectinase, polygalacturonase, dextranase, and planase, chicken egg white lysozyme, human lysozyme, papaya lysozyme, cabra lysozyme, barley lysozyme, zymolyce, lysozyme chloride, glucanase, chitinase Cell wall lytic enzymes such as In the degradation with an enzyme, the concentration, reaction time, reaction temperature, pH of the solution, etc. can be set arbitrarily, but it is particularly preferable to set the optimum value for the enzyme used.

Fermentation or metabolic conversion by microorganisms can be performed by inoculating and growing at least one kind of microorganism on a raw material used as a substrate. Inoculation of microorganisms to the substrate can be done by adding microorganisms directly into the substrate, or by adsorbing them on a carrier such as alginic acid, polyvinyl, gelatin, etc., for example, in the form of fine beads composed of microorganisms and carrier. Further, it can be used by being fixed to the tube wall of the bioreactor. Fermentation or metabolic conversion by microorganisms is not particularly defined as a microorganism to be used, but can generally be defined as microorganisms other than pathogenic microorganisms that exhibit significant toxicity to living bodies. Examples of microorganisms to be used include microorganisms classified into yeasts: Aciculoconidium, Actonia, Aessosporon, Ambrosiozyma, Anthomyces, Apiotrichum, Arthroascus, Arxula, Ashbia, Ashbya, Asporomyces, Atelosaccharomyces Genus, Azymoprocandida, Babjevia, Ballistosporomyces, Bensingtonia, Blastobotrys, Blastodendrion, Blastoderma, Blastoschizomyces, Botryoascus, Botryozyma, Brettanomyces (Brettanomyces
bruxellensis, Brettanomyces anomalus, etc.), Bullera genus, Bulleromyces genus, Candida genus (Candida
albicans, Candida amylolenta, Candida anomala, Candida boidinii, Candida entomaea, Candida
etchellsii, Candida famata, Candida fermentati, Candida guilliermondii, Candida
halophila, Candida intermedia, Candida krusei, Candida lactosa, Candida lipolytica, Candida
mogii, Candida parapsilosis, Candida sake, Candida tropicalis, Candida versatilis, Candida
vulgaris etc.), Castellania genus, Chlamydozyma genus, Chromotorula genus, Citeromyces genus, Cladosporium genus, Clavispora genus, Crebrothecium genus, Cryptococcus genus, Debaryomyces genus (Debaryomyces genus)
delbrueckii, Debaryomyces halotolerans, Debaryomyces hansenii etc.), Debaryozyma genus, Dekkera genus, Dekkeromyces genus, Dematium genus, Dipodascus genus, Eeniella genus, Endomyces genus, Endomycopsis sp Filobasidium genus, Galactomyces genus, Geotrichoides genus, Geotrichum genus, Guilliermondella genus, Hanseniaspora genus, Hansenula genus (Hansenula
anomala, Hansenula kluyveri, Hansenula miso, Hansenula polymorpha, Hansenula
wickerhamii etc.), Hypomyces genus, Issatchenkia genus, Kloeckera genus (Kloeckera brevis, Kloeckera
fluorescens, Kloeckera japonica, etc.), Kloeckeraspora, Kluyveromyces (Kluyveromyces)
bulgaricus, Kluyveromyces marxianus, Kluyveromyces thermotolerans, etc.), Kockovaella, Kurtzmanomyces, Leucosporidium, Lipomyces, Metschnikowia, Microanthomyces, Monilia, Monospora, Genus Genus, Mycotoruloides, Myxozyma, Nadsonia, Nectaromyces, Nematospora, Octosporomyces, Ogataea, Oidium, Oospora, Oosporidium, Pachysolen, Parasaccharomyces, Paratorulopsis, Parendospies, Pichia
amylophila, Pichia farinosa, Pichia guilliermondii, Pichia membranifaciens, Pichia
mogii etc.), Pityrosporum genus, Procandida genus, Procandida genus, Proteomyces genus, Pseudomonilia genus, Pseudosaccharomyces genus, Pseudozyma genus, Rhodomyces genus, Rhodosporidium genus, Rhodotorula genus, Saccharomyces genus (Saccharomyces genus)
aceti, Saccharomyces cerasi, Saccharomyces cerevisiae, Saccharomyces exiguus, Saccharomyces
unisporus, Saccharomyces fibuligera, etc.), Saccharomycodes, Saccharomycopsis, Saturnispora, Schizoblastosporion, Schizosaccharomyces, Schwanniomyces, Selenotila, Selenozyma, Smithiozymaus, Sporidiobolus, Sporidiobolus Genus, Syringospora, Tetrapisispora, Torula, Torulaspora, Torulopsis, Trichosporon, Udeniomyces, Waltomyces, William, Williamopsis, Wingea, Xanthophyllomyces, Yamadazyma, Zenderasp, Zygabo, Zygabo Examples include the genus Zygosaccharomyces and the genus Zymodebaryomyces. Microorganisms classified as bacteria include the genus Acetobacter (Acetobacter
aceti, etc.), Achromobacter genus, Acidianus genus, Acidobacterium genus, Acidithiobacillus genus, Acrocarpospora genus, Actinoalloteichus genus, Actinocorallia genus, Actinokineospora genus, Actinomadura genus, Actinoplanes genus, Agronococcus genus, Actinosco Genus, Genus Ahrensia, Alcaligenes, Alicyclobacillus, Alloiococcus, Alteromonas, Amorphosporangium, Ampullariella, Amycolata, Amycolatopsis, Aquaspirillum, Arcanobacterium, Arthrobacter, Aureobacterium, Bacillus, Azotobacter
brevis, Bacillus subtilis, etc.), Bacteroides genus, Beneckea genus, Bifidobacterium genus (Bifidobacterium
bifidum, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis, etc.), Brachybacterium genus, Brevibacillus genus, Brevibacterium genus, Brevundimonas genus, Burkholderia genus, Carnobacterium genus, Catellatospora genus, Cellulomonas genus, Chromobacterium genus, Chrysactacter genus, Chrysactacter genus, Chrysactacter Genus, Corynebacterium, Couchioplanes, Cryptosporangium, Curtobacterium, Dactylosporangium, Deinococcus, Delftia, Demetria, Dermacoccus, Dermatophilus, Elytrosporangium, Enterobacter, Esoraichi, Eschera Exiguobacterium, Faenia, Flameovirga, Flavobacterium, Flexibacter, Geodermatophilus, Glovicatella, Gluconacetobacter, Gluconoacetobacter, Glycomyces, Gordona, Gordonia, Halobacterium, Helicospora , Hyphomonas genus, Intrasporangium genus, Janibacter genus, Jonesia , Kibdelosporangium genus, Kineococcus genus, Kineosporia genus, Kitasatoa genus, Kitasatospora genus, Kitasatosporia spp., Klebsiella spp., Kocuria genus, Kurthia spp., Lactobacillus genus (Lactobacillus
rimae, Lactobacillus divergens, Lactobacillus carnis, Lactobacillus piscicola, Lactobacillus
acidophilus, Lactobacillus amylophilus, Lactobacillus animalis, Lactobacillus
brevis, Lactobacillus casei, Lactobacillus curvatus, Lactobacillus bulgaricus, Lactobacillus
delbrueckii, Lactobacillus fermentum, Lactobacillus fructivorans, Lactobacillus
fructosus, Lactobacillus helveticus, Lactobacillus hilgardii, Lactobacillus
homohiochii, Lactobacillus kefiri, Lactobacillus malefermentans, Lactobacillus
murinus, Lactobacillus paracasei, Lactobacillus paracasei subsp. tolerans, Lactobacillus
parakefiri, Lactobacillus pentosus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus
rhamnosus, Lactobacillus sakei, Lactobacillus confusus, Lactobacillus viridescens, Lactobacillus
johnsonii, Lactobacillus viscosus, Lactobacillus fermentatae, Lactobacillus
acidophil-aerogenes, Lactobacillus leichmannii, Lactobacillus gasseri, Lactobacillus
bifidus, Lactobacillus jugurt, Lactobacillus caucasicus, Lactobacillus arabinosus, Lactobacillus
kunkeei, Lactobacillus nagelii, Lactobacillus fornicalis, Lactobacillus
pentoaceticus, Lactobacillus xylosus, Lactobacillus minutus, etc.), Leuconostoc (Leuconostoc)
lactis, Leuconostoc dextranicum, Leuconostoc mesenteroides, Leuconostoc oenos, Leuconostoc
paramesenteroides, Leuconostoc cremoris, Leuconostoc citrovorum, etc.), Listonella genus, Lucibacterium genus, Luteococcus genus, Magnetospirillum genus, Marinilabilia genus, Mesorhizobium genus, Metallosphaera genus, Microcoppo, Microcop , Mycoplasma genus, Nocardia genus, Nocardioides genus, Nonomuraea genus, Nonomuria genus, Oceanospirillum genus, Ochrobactrum genus, Oerskovia genus, Oligella genus, Paenibacillus genus, Pediococcus genus (Pediococcus genus)
cerevisiae, Pediococcus pentosaceus, Pediococcus urinae-equi etc.), Pedobacter genus, Peptococcus genus, Peptostreptococcus genus, Pilimelia genus, Planobispora genus, Planococcus genus, Provotella genus, Prevotella genus, Prevotella genus, Provotella genus, Provotella genus , Pseudonocardia genus, Rahnella genus, Rarobacter genus, Rathayibacter genus, Rhizobium genus, Rhozomonas genus, Rhodobacter genus, Rhodococcus genus, Rhodopseudomonas genus, Rhodospirillum genus, Rothia genus, Ruberia monothra, Norra Genus, Sphingobacterium, Sphingomonas, Sporolactobacillus, Stenotrophomonas, Streptoalloteichus, Streptococcus (Streptococcus
durans, Streptococcus faecalis, Streptococcus faecium, Streptococcus bovis, Streptococcus
equinus, Streptococcus mutans, Streptococcus salivarius, Streptococcus
thermophilus, Streptococcus agalactiae, Streptococcus mitis, Streptococcus
pyogenes, Streptococcus pneumoniae, Streptococcus lactis, Streptococcus
dysgalactiae, Streptococcus sanguis, Streptococcus acidominimus, Streptococcus
avium, Streptococcus uberis, Streptococcus cremoris, Streptococcus diacetilactis, etc.), Streptomyces genus, Streptosporangium genus, Streptoverticillium genus, Thermobacter genus, Thermoobifida genus, Thermobispora genus, Thermomospmono genus, Thermomospmono Genus, Weissella, Xanthobacter, Xanthomonas, Zymomonas and the like. Microorganisms classified as non-yeast ascomycetes, basidiomycetes or incomplete fungi include Allomyces, Amoebidium, Amorphotheca, Arthroderma, Ascoidea, Ascobolus, Ascodesmis, Aspergillus, Aureobasidium, Botryosphaeria Botryotinia sp Genus, Dothidea genus, Endogone genus, Entomophthora genus, Emericella genus, Eupenicillium genus, Eurotium genus, Exobasidium genus, Gibberella genus, Glomus genus, Graphiola genus, Gymnoascus genus, Harpella genus, Helicomyces genus, Helvella genus, Hemicarpenteles genus, Hyphochytrium genus, Hyphochytrium Hypocrea, Laboulbenia, Labyrinthula, Leptosphaeria, Leptosphaerulina, Lophodermium, Melanotaenium, Microascus, Microstroma, Medeololaria, Melampsora , Melamsporella, Morchella, Monascus, Monilinia, Mycospharella, Nannizzia, Nectria, Neolecta, Neurospora, Nodulosphaeria, Olpidium, Peziza, Penicillium, Perenospora, Pestopolisis Genus, Pneumocystis genus, Preussia genus, Pleospora genus, Puccinia genus, Pythium genus, Ravenelia genus, Rickia genus, Rhinocladiella genus, Rhizidiomyces genus, Rhizoctonia genus, Sclerocleista genus, Saprolegnia genus, Sclerotinia genus, Sclerotum genus, Septobasidium genus, Septobasidium genus Examples include Sporidiobolus genus, Stigmatomyces genus, Sydowiella genus, Talaromyces genus, Taphrina genus, Thraustochytrium genus, Tolyposporium genus, Trichoglossum genus, Trichoma genus, Ustilago genus, Verticillium genus, Xylaria genus and the like.

  In fermentation or metabolic conversion by microorganisms, in addition to various raw materials such as plant-based materials, animal-based materials, and other natural product-based materials, the growth and metabolism of microorganisms are regulated or activated, and special biosynthesis or degradation pathways are induced. In order to achieve this, various compounds can be added to the raw material. For example, as a carbon source, sugar, ethane such as glucose, fructose, galactose, sucrose, maltose, mannose, lactose, glycerin, starch, etc. , Hydrocarbons such as methane, propane, butane, formic acid, acetic acid, propionic acid, lauric acid, palmitic acid, fatty acids such as oleic acid, linoleic acid, linolenic acid, etc., nitrogen sources such as ammonium sulfate, ammonium hydrochloride, ammonium phosphate, etc. Ammonium salts, urea, uric acid, amino acids, etc. Vitamins and compounds containing potassium, calcium, magnesium, sodium, sulfur, phosphorus, chlorine, etc., as well as iron, copper, zinc, cobalt, nickel, boron, manganese, molybdenum, tin, selenium, silicon It is possible to further add compounds contained in the composition such as arsenic, vanadium, chromium and fluorine. In addition, the optimum temperature, oxygen supply amount, pH, pressure, etc. that affect the growth and metabolic activities of various microorganisms can be arbitrarily set according to the characteristics inherent to various microorganisms. Can be arbitrarily set within the range of 10 to 50 ° C., and the pH can be arbitrarily set within the range of 1 to 14.

  In fractionation or purification, generally known techniques can be used as appropriate. In addition to solvent extraction, for example, liquid chromatography (ion exchange chromatography, ion exclusion chromatography, affinity chromatography, gel filtration chromatography, size exclusion chromatography, etc.). Chromatography, hydrophilic adsorption chromatography, hydrophobic adsorption chromatography, ligand exchange chromatography, etc.) fractionation using a single column or multiple columns, dialysis with semipermeable membranes, crystallization and recrystallization of components. Examples thereof include crystallization, filter paper, membrane filter, ultrafilter, filtration using activated carbon, filter aid, etc., centrifugal separation and its application, fractional precipitation method, density gradient separation method such as density gradient sedimentation equilibrium method, and the like.

Specific examples of other components other than the above used as additives in the present invention include silicic anhydride, magnesium silicate, talc, kaolin, bentonite, hectorite, natural or synthetic smectite, stevensite, mica, mica titanium, oxy Inorganic pigments such as bismuth chloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, bengara, black iron oxide, gunjou, chromium oxide, chromium hydroxide, carbon black, calamine, Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate , Silicic acid Thorium hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide and other inorganic reducing agents , Redox agents such as thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate), 5-aminoorthocresol, 2-amino-4 -Nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene hydrochloride -2,5-diamine, nitroparaphenylenedia hydrochloride , Paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5- Dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium picrate, N , N′-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, Metaphenylenediamine, 5-aminoorthocreso sulfate 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, Nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine, catechol, diphenylamine, α -Naturol, hydroquinone, phloroglucin, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sodium sulfonate, dyes such as hematein, natural materials such as musk, civet, castrium, ambergris Animal flavors, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam Essential oil, Koreanel essential oil, Perilla essential oil, Cedarwood essential oil, Citronella essential oil, Jasmine essential oil, Gingergrass essential oil, Cedar essential oil, Spearmint essential oil, Western peppermint essential oil, Otsuka perfume essential oil, Cube rose essential oil, Clove essential oil, Orange flower essential oil, Winter green essential oil, Truval Sam Essential Oil, Baturi Essential Oil, Rose Essential Oil, Palmarosa Essential Oil, Crude Essential Oil, Hiba Essential Oil, Sandalwood Essential Oil, Petit Glen Essential Oil, Bay Essential Oil, Bechiba Essential Oil, Bergamot Essential Oil, Peruvian Sam Essential Oil, Boadrose Essential Oil, Mango Essential Oil, Mandarin Essential Oil, Eucalyptus Essential Oil Lime essential oil, lavender essential oil, Linaroe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, vegetable flavors such as Japanese mint essential oil, other synthetic flavors, 5-amino-o-cresol, o-aminophenol, m-aminophenol, p-aminophenol, 2,6-diaminopyridine, 5- (2-hydroxylethylamino) -2-methylphenol, N, N-bis (β-hydroxyl) -p-phenylenediamine sulfate, N, N-bis (2-hydroxyethyl) -p-phenylenediamine, p-nitro-o-phenylenediamine, p-phenylenediamine, m-phenylenediamine, N-phenyl-p-phenylenediamine, 2-hydroxy-5 -Nitro-2 ', 4'-diaminoazobenzenesodium sulfate, toluene-2,5-diamine, 2- (2'-hydroxyethylamino) -5-aminotoluene, N, N-bis (β-hydroxyl) -p -Fillere Diamine, N, N-bis (2-hydroxyethyl) -p-phenylenediamine sulfate, 5-amino-o-cresol sulfate, p-aminophenol sulfate, o-chloro-p-phenylenediamine sulfate, 2 -(2'-hydroxyethylamino) -5-aminotoluene sulfate, 4,4'-diaminodiphenylamine sulfate, p-methylaminophenol sulfate, p-phenylenediamine sulfate, m-phenylenediamine sulfate, toluene -2,5-diamine sulfate, 2,4-diaminophenoxyethanol hydrochloride, toluene-2,5-diamine hydrochloride, m-phenylenediamine hydrochloride, 2,4-diaminophenol hydrochloride, 3,3'-imino Diphenol, p-phenylenediamine hydrochloride, N-phenyl-p-phenylenediamine hydrochloride, N-phenyl-p-phenylenediamine acetate, 1,5-dihydroxynaphthalene, toluene-3,4-diamine, p-methyl amino Enol, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, o-aminophenol sulfate, 2,4-diaminophenol sulfate, m-aminophenol sulfate, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, nitro-p-phenylenediamine hydrochloride, 1,4-diaminoanthraquinone, nitro-p-phenylenediamine , Picramic acid, sodium picramate, 2-amino-5-nitrophenol sulfate, resorcinol, nitro-p-phenylenediamine sulfate, p-nitro-o-phenylenediamine sulfate, p-nitro-m-phenylenediamine sulfate Salt, red 2, red 3, red 102, red 104 (1), red 105 (1), red 106, red 201, red 227, red 230 (1), Red No. 230 (2), Red No. 231, Red No. 232, Red 401, Red 502, Red 503, Red 504, Red 506, Yellow 4, Yellow 5, Yellow 202 (1), Yellow 202 (2), Yellow 203, Yellow 402 Yellow 403 (1), Yellow 406, Yellow 407, Orange 205, Orange 207, Orange 402, Green 3, Green 204, Green 205, Green 401, Green 402, Brown 201, purple 401, blue 1, blue 2, blue 202, blue 203, blue 205, black 401, red cabbage pigment, red yeast rice pigment, catechol tannin, red rice pigment, red rice pigment, Anato Dye, Ikumi Dye, Turmeric Dye, Enju Dye, Krill Dye, Caramel Dye, Caramel, Gold, Silver, Gardenia Dye, Corn Dye, Onion Dye, Tamarind Dye, Spirulina Dye, Cherry Dye, Nori Dye, Hibiscus Dye, Grape Juice Dye , Grape skin pigment, marigold pigment, purple potato pigment, purple yam pigment, Colors and coloring agents such as lac color, rutin, avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber nut Oil, safflower oil, shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel Oils, molasses, palm oil, beef tallow, lard, hydrogenated oils (hardened oil, etc.) of these fats, beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax , Shellac wax, rice wax, squalene, squalane, pristane, etc. Mineral oils such as fin, petrolatum, paraffin, ozokelide, ceresin, microcristan wax, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12 -Natural fatty acids such as hydroxy stearic acid, undecylenic acid, tall oil, lanolin fatty acid, synthetic fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid, isopentanoic acid Fatty acids such as ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, and other natural alcohols, 2-hexylde Alcohols such as canol, isostearyl alcohol, synthetic alcohol such as 2-octyldodecanol, isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, myristic acid Octyldodecyl, hexyldecyl dimethyloctanoate, diisobutyl adipate, 2-hexyldecyl adipate, diheptylundecyl adipate, N-alkyl glycol monoisostearate, isocetyl isostearate, trimethylolpropane triisostearate, ethylene glycol diethylhexanoate , Neopentyl glycol diethylhexanoate, cetyl 2-ethylhexanoate, trimethylolpropane triethylhexanoate, tetraethylene Esters such as pentaerythritol hexanoate, cetyl octanoate, octyldodecyl gum, cetyl lactate, myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate , Metal soaps such as aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate, anionic surfactants (alkyl carboxylates, alkyl sulfonates) Salt, alkyl sulfate ester salt, alkyl phosphate ester salt), alkyl sulfate ester salt (sodium lauryl sulfate, potassium lauryl sulfate, lauryl sulfate salt) Reethanolamine, ammonium lauryl sulfate, sodium cetyl sulfate, sodium stearyl sulfate, etc., secondary alcohol sulfate ester salt, alkyl ether sulfate ester salt (for example, polyoxyethylene lauryl sulfate triethanolamine, polyoxyethylene lauryl sodium sulfate, etc.), Alkyl and alkyl allyl ether sulfates (N-acyl methyl alanine, N-acyl glutamate, N-acyl methyl taurate, N-acyl isethionate, N-acyl glycine, alkyl phosphate, alkyl ether carboxylic acid Salt, alkyl sulfonate, alkyl sulfosuccinate, polyoxyethylene lauryl ether sodium sulfate, polyoxyethylene lauryl ether triethanolamine, polyoxyethylene lauryl ester Ammonium sulfate, polyoxyethylene alkyl ether sodium sulfate, polyoxyethylene alkyl ether sulfate triethanolamine, polyoxyethylene alkyl ether sulfate diethanolamine, polyoxyethylene alkyl ether ammonium sulfate, etc.), higher fatty acid alkylolamide sulfate, higher fatty acid ester Sulfated ester salts (hardened coconut oil fatty acid sodium glycerine sulfate, etc.), polyoxyethylene alkyl ether carboxylic acids, polyoxyethylene alkyl allyl ether carboxylates, sulfated castor oil and other sulfated oils, mono or dialkyl or alkenyl phosphates Salt, polyoxyethylene mono or dialkyl or alkenyl phosphate ester salt (sodium monolauryl phosphate, isostearyl phosphorus Sodium, 2-hexyl decyl phosphate arginine, 2-heptyl undecyl
Potassium phosphate, polyoxyethylene (4-10) sodium lauryl ether phosphate, sodium monocetyl phosphate, arginine monomyristyl phosphate, sodium monooleyl phosphate, polyoxyethylene (2-10) potassium lauryl ether phosphate, dioctyl phosphorus Acid salt), phosphoric acid ester salt of polyoxyethylene alkyl ether (polyoxyethylene lauryl ether phosphoric acid, polyoxyethylene oleyl ether phosphoric acid, polyoxyethylene cetyl ether phosphoric acid, polyoxyethylene stearyl ether phosphoric acid, polyoxy Ethylene alkyl ether phosphoric acid, polyoxyethylene alkyl phenyl ether phosphoric acid, etc.), sulfonate of higher fatty acid amide or sulfonate of higher fatty acid ester (α-olefin sulfonic acid) , N-myristoyl-N-methyltaurine sodium, coconut oil fatty acid methyltaurine sodium, lauroylmethyltaurine sodium, etc., alkylbenzene sulfonates (dodecylbenzenesulfonic acid, dodecylbenzenesulfonic acid monoethanolamine, dodecylbenzenesulfonic acid diethanolamine, dodecyl) Benzenesulfonate triethanolamine, sodium dodecylbenzenesulfonate, etc., sulfosuccinate (diethylhexyl sulfosuccinate, sodium sulfosuccinate, disodium lauryl sulfosuccinate, disodium polyoxyethylene sulfosuccinate, disodium polyoxyethylene sulfosuccinate, dilauryl polyoxyethylene sulfosuccinate Sodium, disodium sulfosuccinic acid polyoxyethylene lauroyl ethanolamide ester, Undecylenoylamide ethyl sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sodium sodium sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc.), N-acyl sarcosine salts (such as sodium lauroyl sarcosine, palmitoyl sarcosine sodium), higher fatty acids and Condensates of amino acids (N-acylglutamate, sodium N-stearoylglutamate, potassium N-palmitoylglutamate, sodium N-lauroyl-L-glutamate, disodium N-stearoyl-L-glutamate, sodium N-myristoyl-L-glutamate , Myristoyl methyl taurine sodium, palmitoyl methyl taurine sodium, stearoyl methyl taurine sodium, N-palmitoyl-β-a Anionic surfactants such as fatty acid soaps such as nin arginine, N-palmitoyl aspartate ditriethanolamine), oleate, suarate, laurate, palmitate etc. For example, alkali metal salts such as sodium salts and potassium salts, monoethanolamine salts, diethanolamine salts, triethanolamine salts, organic ammonium salts such as L-lysine salts and L-arginine salts, ammonium salts, etc.) Quaternary ammonium salts (alkyl trimethyl ammonium chloride, cetyl ammonium chloride, cetyl ammonium bromide, lauryl ammonium chloride, lauryl ammonium bromide, stearyl ammonium chloride, stearyl ammonium bromide, cetyl dimethyl ammonium chloride, cetyl dimethyl methacrylate Ammonium, lauryl dimethyl ammonium chloride, stearyl dimethyl ammonium chloride, lauryl trimethyl ammonium chloride, lauryl trimethyl ammonium bromide, stearyl dimethyl cetyl ditallow dimethyl ammonium chloride, dicetyl ammonium chloride, dicetyl ammonium bromide, dilauryl ammonium chloride, bromide Dilauryl ammonium, distearyl ammonium chloride, distearyl ammonium bromide, dicetyl methyl ammonium chloride, dicetyl methyl ammonium bromide, dilauryl methyl ammonium chloride, dilauryl methyl ammonium bromide, distearyl methyl ammonium chloride, distearyl methyl bromide Stearylmethylammonium, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, stearyl chloride Rutrimethylammonium, stearyltrimethylammonium bromide, lauryltrimethylammonium bromide, dialkyldimethylammonium chloride, dicetyldimethylammonium chloride, distearyldimethylammonium chloride, dicocoyldimethylammonium chloride, myristyldimethylbenzylammonium chloride, stearyldimethylbenzylammonium chloride Lanolin fatty acid ethylpropylethyldimethylammonium sulfate, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, behenyltrimethylammonium chloride, behenyldimethylhydroxyethylammonium chloride, stearyldimethylbenzylammonium chloride, distearyldimethylammonium chloride, distearoylethylhydroxyl Ethylmonium metasulfate, dicocoylethylhydroxyethylmonium metasulfate, dipalmitoylethylhydroxyethylmonium metasulfate, and cetyltriethylammonium methylsulfate, alkyltrimethylammonium chloride, alkyldimethylbenzylammonium chloride, dialkyldimethylammonium chloride, alkyltrimethyl bromide Ammonium, alkylpentaethoxyammonium chloride, ditallowdimethylammonium chloride, ditallowdimethylammonium methylsulfate, ditallowdipropylammonium phosphate, ditallowdimethylammonium nitrate, di (coconutalkyl) dimethylammonium chloride, di (coconutalkyl) dimethylbromide Ammonium and coconut chloride Monium, stearamide propyl chloride PG-dimonium phosphate, stearamide propyl ethyl dimonium esosulphate, stearamide propyl dimethyl (myristyl acetate) ammonium chloride, stearamide propyl dimethyl cetearyl ammonium tosylate, stearamide propyl Dimethyl ammonium chloride, stearamide propyl dimethyl ammonium lactate, ethyl sulfate lanolin fatty acid aminopropyl ethyl dimethyl ammonium, cationized cellulose, acyl diethyl amino ethyl amide, acyl dimethyl amino propyl amide, polyoxyethylene fatty acid amide, myristyl dimethyl amine oxide, N- Lauryldimethylaminoacetic acid betaine, N-myristyldimethylaminoacetic acid betaine, N-stearyl dimethyl Tilaminoacetic acid betaine), bis fatty acid ester salt (hydroxypropyl-bis-lauric acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-myristic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl- Bis-palmitic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-stearic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-behenic acid amidopropyl-N, N-dimethylammonium chloride , Hydroxypropyl-bis-oleic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-isostearic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-coconut Fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-tallow fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxy Propyl-bis-lauric acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-myristic acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palmitic acid amidoethyl-N, N-diethylammonium chloride, Hydroxypropyl-bis-amidoethyl stearate-N, N-diethylammonium chloride, hydroxypropyl-bis-amidoethyl behenate-N, N-diethylammonium chloride, hydroxypropyl-bis-oleic acid Doethylammonium chloride, hydroxypropyl-bis-isostearic acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-tallow fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-lauramidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-myristate amidopropyl -N, N-diethylammonium chloride, hydroxypropyl-bis-palmitic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-stearic acid amidopropyl-N, N -Diethylammonium chloride, hydroxypropyl-bis-behenic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-oleic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-isostearic acid amidopropyl -N, N-diethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis- Beef tallow fatty acid amidopropyl-N, N-diethylammonium chloride, etc.), stearamidepropyl PG-dimonium chloride phosphate, behenamidopropyl PG dimonium chloride, stearamidepropylethyldimonium Cationic surfactants such as etosulphate, stearamide propyl dimethyl (myristyl acetate) ammonium chloride, stearamide propyl dimethyl cetearyl ammonium tosylate, stearamide propyl dimethyl ammonium chloride, stearamide propyl dimethyl ammonium lactate, Glycerin fatty acid ester (glyceryl monoundecylate, glyceryl diundecylenate, glyceryl monomyristate, glyceryl dimyristate, glyceryl monopalmitate, glyceryl dipalmitate, glyceryl monostearate, glyceryl distearate, glyceryl monooleate, mono cottonseed oil Fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, glyceryl monostearate, α, α'-ole Glyceryl pyroglutamate, glyceryl monostearate, polyglycerin fatty acid ester (diglyceryl monomyristate, diglyceryl dimyristate, diglyceryl trimyristate, diglyceryl monopalmitate, diglyceryl dipalmitate, Diglyceryl tripalmitate, diglyceryl monostearate, diglyceryl distearate, diglyceryl tristearate, diglyceryl monooleate, diglyceryl dioleate, diglyceryl trioleate, tetraglyceryl monopalmitate, tetradipalmitate tetra Glyceryl, tetraglyceryl tripalmitate, tetraglyceryl tetrapalmitate, tetraglyceryl pentapalmitate, tetraglyceryl monostearate, disteary Tetraglyceryl acid, tetraglyceryl tristearate, tetraglyceryl tetrastearate, tetraglyceryl pentastearate, tetraglyceryl monooleate, tetraglyceryl dioleate, tetraglyceryl trioleate, tetraglyceryl tetraoleate, tetraglyceryl pentaoleate , Hexaglyceryl monopalmitate, hexaglyceryl dipalmitate, hexaglyceryl tripalmitate, hexaglyceryl tetrapalmitate, hexaglyceryl pentapalmitate, hexaglyceryl monostearate, hexaglyceryl distearate, hexaglyceryl tristearate, tetrastearate Hexaglyceryl acid, hexaglyceryl pentastearate, hexaglyceryl monooleate, di Hexaglyceryl oleate, hexaglyceryl trioleate, hexaglyceryl tetraoleate, hexaglyceryl pentaoleate, depalg monopalmitate
Lyseryl, decaglyceryl dipalmitate, decaglyceryl tripalmitate, decaglyceryl tetrapalmitate, decaglyceryl pentapalmitate, decaglyceryl hexapalmitate, decaglyceryl heptapalmitate, decaglyceryl octapalmitate, decaglyceryl nonapalmitate, Decaglyceryl decapalmitate, decaglyceryl monostearate, decaglyceryl distearate, decaglyceryl tristearate, decaglyceryl tetrastearate, decaglyceryl pentastearate, decaglyceryl hexastearate, decaglyceryl heptearate, octastearic acid Decaglyceryl, nona stearate decaglyceryl, decastearate decaglyceryl, monooleate decaglyceryl, di Decaglyceryl oleate, decaglyceryl trioleate, decaglyceryl tetraoleate, decaglyceryl pentaoleate, decaglyceryl hexaoleate, decaglyceryl heptaoleate, decaglyceryl octaoleate, decaglyceryl nonaoleate, decaglyceryl decaoleate Decaglyceryl monohydroxystearate, decaglyceryl dihydroxystearate, decaglyceryl trihydroxystearate, decaglyceryl tetrahydroxystearate, decaglyceryl pentahydroxystearate, decaglyceryl hexahydroxystearate, decaglyceryl heptahydroxystearate, octa Decaglyceryl hydroxystearate, decaglyceryl nonahydroxystearate, deca Droxyglyceryl droxystearate, hexaglyceryl polyricinoleate, decaglyceryl polyricinoleate, polyoxyethylene glyceryl monostearate, polyoxyethylene glyceryl distearate, polyoxyethylene glyceryl monooleate, polyoxyethylene glyceryl monomyristate, etc. ), Polyoxyethylene glycerin fatty acid ester (polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate, etc.), sorbitan fatty acid ester (sorbitan monolaurate, sorbitan monooleate, Sorbitan sesquioleate, sorbitan trioleate, sorbitan monopalmitate, sorbitan monostearate Sorbitan distearate, sorbitan dioleate, sorbitan monopalmitate, sorbitan tristearate, sorbitan trioleate, diglycerine sorbitan penta-2-ethylhexylate, diglycerin sorbitan tetra-2-ethylhexylate, polyoxyethylene monooleate Sorbitan, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan trioleate, polyoxyethylene sorbitan pentaoleate), propylene glycol fatty acid ester (monooctane) Propylene glycol, propylene glycol monodecanoate, propylene glycol monostearate, etc.), sucrose fatty acid ester Tell (monolauric acid sucrose ester, dilauric acid sucrose ester, monopalmitic acid sucrose ester, dipalmitic acid sucrose ester, monostearic acid sucrose ester, distearic acid sucrose ester, etc.), dextrin fatty acid ester (dextrin palmitate) Etc.), palm oil fatty acid alkanolamide, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil Monopyroglutamic acid monoisostearic acid diester, polyoxyethylene hydrogenated castor oil maleic acid, polyoxyethylene alkyl ether (alkyl polyglucoside, polyoxyethylene cetyl ether, Reoxyethylene stearyl ether, polyoxyethylene behenyl ether, polyoxyethylene oleyl ether, polyoxyethylene lauryl ether, polyoxyethylene-2-octyldodecyl ether, polyoxyethylene cholestanol ether, etc.), polyoxyethylene alkylphenyl ether ( Polyoxyethylene nonylphenyl ether, polyoxyethylene octylphenyl ether, etc.), polyoxyethylene fatty acid esters (polyethylene glycol monooleate, polyethylene glycol monostearate, polyethylene glycol monolaurate, etc.), lanolin derivatives (polyoxyethylene lanolin, poly Oxyethylene lanolin alcohol, polyoxyethylene sorbitol lanolin, etc.), POE / POP-alkyl Ether (POE / POP-cetyl ether, POE / POP-2-decyltetradecyl ether, POE / POP-monobutyl ether, POE / POP-hydrogenated lanolin, POE / POP-glycerin ether, Tetronic, etc.), alkanolamide ( Nonionic surfactants such as coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc., betaine-type amphoteric surfactant (2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine) , Lauryldimethylaminoacetic acid betaine, undecylcarboxymethoxyethylcarboxymethylimidazolinium betaine sodium, undecylhydroxyethylimidazolinium betaine sodium, undecyl-N-hydroxyethyl-N-carboxymethylimidazolinium betaine, alkyl hydrochloride Diaminoethylglycine solution, stearyl dihydroxyethyl betaine, stearyldimethylaminoacetic acid betaine, sodium stearyldimethylbetaine solution, coconut oil alkyl-N-carboxyethyl-N-hydroxyethylimidazolinium betaine sodium, coconut oil alkylbetaine, coconut oil alkyldimethyl Aminoacetic acid betaine, coconut oil fatty acid amidopropyl betaine, coconut oil fatty acid-N-carboxymethoxyethyl-N-carboxyethylimidazolinium betaine sodium, N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, N -Cocoyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, lauryldimethylaminoacetic acid hydroxysulfobetaine, coconut oil alkyldimethylaminoacetic acid hydroxy Sulfobetaine, triethanolamine laurylaminopropionate, sodium β-laurylaminopropionate, amidopropyldimethylaminoacetic acid betaine laurate, amidopropyldimethylaminoacetic acid hydroxysulfobetaine, coconut oil fatty acid amidopropyldimethylaminoacetic acid hydroxysulfobetaine , Palm oil fatty acid amidopropyldimethylaminoacetic acid hydroxysulfobetaine, palm oil fatty acid amidopropyldimethylaminoacetic acid betaine, palm oil fatty acid amidopropyldimethylaminoacetic acid betaine, lauryl-N-carboxymethoxyethyl-N-carboxymethylimidazolinium disodium Dodecanoyl sarcosine, sodium lauryldiaminoethylglycine, amidopropyl betaine laurate, lauryl Sulfobetaine, laurylhydroxysulfobetaine, 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, cocodimethylcarboxymethylbetaine, lauryldimethylcarboxymethylbetaine, lauryldimethylalphacarboxyethylbetaine, cetyldimethylcarboxymethylbetaine Cetyldimethylbetaine, laurylbis- (2-hydroxyethyl) carboxymethylbetaine, stearylbis- (2-hydroxypropyl) carboxymethylbetaine, oleyldimethylgamma-carboxypropylbetaine, laurylbis- (2-hydroxypropyl) alpha-carboxyethyl Betaine, Cocodimethylsulfopropylbetaine, Stearyldimethylsulfopropylbetaine, Lauryldimethylsulfate Ethyl betaine, lauryl bis- (2-hydroxyethyl) sulfopropyl betaine, Levon 2000 (Sanyo Chemical Co., Ltd.), coconut oil fatty acid amidopropyl dimethyl betaine, coconut oil fatty acid amidopropyl sulfobetaine, imidazolinium type amphoteric surfactant (bis (Stearyl-N-hydroxyethylimidazoline) chloroacetic acid complex, N-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-alkyl-N-carboxymethyl-N-hydroxyethylethylenediamine / lauryl sulfate and its Salt, coconut oil alkyl-N-carboxyethoxyethyl-N-carboxyethyl imidazolinium disodium hydroxide, coconut oil alkyl-N-carboxymethoxyethyl-N-carboxyethyl imidazolinium disodium hydroxide, coconut oil alkyl- N-Cull Xoxymethoxyethyl-N-carboxyethylimidazolinium disodium lauryl sulfate, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide 1-carboxyethyloxy disodium salt, ovazoline 662 (Toho Chemical Co., Ltd.), Swanol AM-101 (Nikko Chemicals Co., Ltd.), aminopropionic acid type amphoteric surfactants (alkylaminopropionic acid such as sodium dodecylaminopropionate, alkyl Aminodipropionic acid, etc.), sodium dodecylaminopropanesulfonate, N-higher alkylaspartic acid or its salt, coamidopropyl chlorinated polyethylene glycol dimonium phosphate, cocamidopropyl hydroxysultain, sodium lauroyl sarcosinate, alkyl Amphoteric surfactants such as minoxide (decylamine oxide, cocoamine oxide, myristoylamine oxide, palmitoylamine oxide, alkyldimethylamine oxide, alkylamidopropylamine oxide), natural surfactants (lecithin, sodium caseinate, sphingolipid) Saponins, mannosyl polyhydric alcohol fatty acid esters, glucosyl polyhydric alcohol fatty acid esters, monosaccharide polyhydric alcohol fatty acid esters such as galactosyl polyhydric alcohol fatty acid esters, disaccharide polyhydric alcohol fatty acid esters, oligosaccharide polyhydric alcohol fatty acid esters, etc.) And amino acid surfactants (capric acid chloride, lauric acid chloride, myristic acid chloride, palmitic acid chloride, stearic acid chloride, oleic acid Reaction products of fatty acid chlorides such as rholide, behenic acid chloride, coconut oil fatty acid chloride and the like with glycine, sarcosine, β-alanine, N-methyl-β-alanine, taurine, N-methyltaurine, etc.), silicone Surfactant (Silicon KF-6011 (Shin-Etsu Chemical Co., Ltd.), KF-6012 (Shin-Etsu Chemical Co., Ltd.), KF-6013 (Shin-Etsu Chemical Co., Ltd.), KF-6015 (Shin-Etsu Chemical Co., Ltd.), KF -6016 (Shin-Etsu Chemical Co., Ltd.), KF-6017 (Shin-Etsu Chemical Co., Ltd.), X-22-4991 (Shin-Etsu Chemical Co., Ltd.), NUC Silicon L7002 (Nihon Unicar Co., Ltd.), SH-3772C (Toray Dow) Corning Silicone), SH-3775C (Toray Dow Corning Silicone) and other polyoxyalkylene-modified organopolysiloxanes, ABIL
EM-90 (manufactured by Goldschmidt), ABIL B9806 (manufactured by Goldschmidt), silicon KF-6026 (manufactured by Shin-Etsu Chemical Co., Ltd.), etc.) (Polyoxyethylene / methylpolysiloxane copolymer, poly (oxyethylene / oxypropylene) methylpolysiloxane copolymer, etc.), oxazoline-modified organopolysiloxane, alkyl-modified organopolysiloxane, styryl ketone silicone derivative, dimethylpolysiloxane, Methylphenylpolysiloxane, epoxy-modified silicone, fluorine-modified silicone, alcohol-modified silicone, alkyl-modified silicone, alkoxy-modified silicone, amino-modified silicone, ammonium-modified polymer silicone, Ganopolysiloxane, methylphenylpolysiloxane, polysiloxane, poly (N-acylalkyleneimine) modified silicone, dimethylpolysiloxane, nitrogen-containing acrylic-silicone graft copolymer, decamethylcyclopentasiloxane, fluorine-substituted alkyl-modified silicone, Organopolysiloxanylsilylalkyl modified silicone, tricyclic diterpene carboxylic acid modified silicone, trifluoroalkyl modified silicone, divinylpolydimethylsiloxane, dihydrogenopolydimethylsiloxane, dihydrogenopolydimethylsiloxane divinylpolydimethylsiloxane polymer, trimethyl Siloxysilicic acid, polyoxypropylene / methylpolysiloxane copolymer, ethylpolysiloxane, ethylmethylpolysiloxane, ethylphenol Polysiloxane, octamethylcyclotetrasiloxane, diorganopolysiloxane, octamethylcyclotetrasiloxane, tetramethyltetraphenyltetracyclosiloxane, polyether-modified polysiloxane, amino-modified polysiloxane, epoxy-modified polysiloxane, fluorine-modified polysiloxane , Alcohol-modified polysiloxane, alkyl-modified polysiloxane, dodecamethylcyclohexasiloxane, laurylmethicone copolyol, aminoethylaminopropylsiloxane / dimethylsiloxane copolymer, eugenol-modified silicone and other silicone compounds, selenium disulfide, bromide Examples include hair treatment agents such as alkylisoquinolinium solution, zinc pyrithione, biphenamine, thianthol, quinine hydrochloride, and strong aqueous ammonia.

  Others, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, refreshing agents, stabilizers, emulsifiers, animal / plant proteins and their degradation products, animal / plant polysaccharides and their Degradation products, animal / plant glycoproteins and their degradation products, anti-inflammatory agents, antiallergic agents, wound treatment agents, foaming agents, thickeners, enzymes, purified water (electronic water, small clusters, etc.), deodorant / A deodorant etc. can be used in combination.

  Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

(Production Example 1)
Grind dried artichoke leaves, dried peonies roots, dried loquat leaves, dried lemon balm leaves and stems, and warm each 100g with purified water (about 30 ° C) for about 5 hours. Extract and filter to obtain about 1.0 kg of extract.

(Production Example 2)
Grind dried artichoke leaves, dried peonies roots, dried loquat leaves, dried lemon balm leaves and stems, and warm each 100g with purified water (about 80 ° C) for about 5 hours. Extract and filter to obtain about 1.0 kg of extract.

(Production Example 3)
Grind dried artichoke leaves, dried peony roots, dried loquat leaves, dried lemon balm leaves and dried stem leaves, and immerse 100g each in 50% 1,3-butylene glycol solution The mixture is extracted at room temperature for 5 days and nights, and then filtered to obtain about 1.0 kg of an extract.

(Production Example 4)
Dried artichoke leaves and stems, dried peonies rhizomes, dried loquat leaves, dried lemon balm dry matter, each 100g soaked in 50% ethanol solution and brought to room temperature Extract for 5 days and then filter to obtain about 1.0 kg of extract.

(Production Example 5)
Dried artichoke leaves and stems, dried peonies rhizomes, dried loquat leaves, dried lemon balm above ground, immerse 100g each in 50% propylene glycol solution, 5 at room temperature After extraction day and night, filtration is performed to obtain about 1.0 kg of an extract.

(Test 1) Pro-opiomelanocortin expression suppression test after UV irradiation The present inventor evaluated the expression suppression effect of pro-opiomelanocortin after UV irradiation.
"Test method and evaluation method"
Normal human epidermal cells are seeded at 2 × 10 ⁵ cells / well. After 24 hours, add plant extract or) control solvent. After another 24 hours, the medium is replaced with PBS and irradiated with ultraviolet rays of 6.0 mJ. Thereafter, the medium is replaced, and a plant extract or a control solvent is added. After 24 hours, intracellular mRNA was extracted, and the expression level of the proopiomelanocortin gene was measured by real-time PCR. After the measurement, the pro-opiomelanocortin expression inhibition rate (%) was calculated by determining the specific activity relative to the ultraviolet irradiation group. The results are shown in FIG.
"sample"
The pro-opiomelanocortin expression inhibitory action test sample was prepared by adding 0.5% of each of the artichoke extract, peony extract, loquat leaf extract, and lemon balm extract obtained in Production Example 3 of the present invention. It used for the test. Moreover, as a comparative sample, a dokudami extract was prepared under the same conditions and used for the test.

(Test results)
As a result, it was confirmed that the artichoke extract, peony extract, loquat leaf extract, and lemon balm extract of the present invention have an action of suppressing the expression of proopiomelanocortin as shown in FIG.
In addition, the effect which suppresses the expression of proopiomelanocortin was not recognized in the dokudami extract used as a comparative sample. In addition, the same result which suppresses the expression of pro-opiomelanocortin also for the artichoke extract, the peony extract, the loquat leaf extract, and the lemon balm extract obtained in Production Examples 1-2 and 4-5 of the present invention. Obtained.

(Test 2) Use effect test The effect at the time of actually using the emulsion of this invention was examined. The use test is a panel of 20 women aged 30-60 years old suffering from stains and freckles. After washing the face twice daily in the morning and evening, apply an appropriate amount of the following formula 1 emulsion to the face for 3 months. Was done. In addition, what prepared the thing remove | excluding each plant extract of this invention from the milky lotion by the same method was used for the control | contrast. The evaluation method is based on the following criteria, and the results are as shown in Table 1. The numerical values in the table represent the number of people. No one complained of skin abnormalities during the period of use.

(Formulation Example 1) Emulsion
weight%
1. Squalane 8.0
2. Jojoba oil 7.0
3.Cetyl alcohol 2.0
4.Glycerin monostearate 2.0
5. Polyoxyethylene (20) cetyl ether 3.0
6.1,3-Butylene glycol 1.0
7.Glycerin 1.0
8. A: Artichoke extract of Production Example 3 B: Peonies extract of Production Example 3 C: Loquat leaf extract of Production Example D D: Lemon balm extract of Production Example 3 * Extraction of any one of A to D Liquid 5.0
9. Preservative (methyl paraoxybenzoate) appropriate amount
10. Residue with 100 purified water

"Blemish and freckles improvement effect"
Effective: Blemish and freckles improved.
Slightly effective: Slight freckles improved slightly.
Invalid: No change before use.

(Test results)
As shown in Table 1, it was confirmed that the emulsion containing the artichoke extract, peony extract, loquat leaf extract, and lemon balm extract of the present invention significantly improved spots and freckles.

(Test 3) Use effect test The effect at the time of actually using the cream of this invention was examined. The use test was conducted by 10 healthy persons (20 to 30 years old) who suffered from rough skin as panelists. After washing their hands twice daily in the morning and night, they rubbed the appropriate amount of the cream of the following Formulation Example 2 into their hands for 3 months. It was carried out by coating over the whole area. In addition, as a control, a cream prepared by removing each plant extract of the present invention from a cream was used in the same manner. The evaluation method was performed according to the following criteria, and the results are shown in Table 2. The numbers in the table represent the number of people. No one complained of skin abnormalities during the period of use.

(Formulation example 2) Cream
weight%
1.Squalane 15.0
2.liquid paraffin 15.0
3.Cetanol 3.0
4.Dimethylpolysiloxane 1.0
5.Cholesterol 0.5
6. Vaseline 2.0
7.Glycerin 5.0
8. A: Artichoke extract of Production Example 3 B: Peonies extract of Production Example 3 C: Loquat leaf extract of Production Example D D: Lemon balm extract of Production Example 3 * Extraction of any one of A to D Liquid 5.0
9. Antibacterial / preservative (2-phenoxyethanol)
10. Residue with 100 purified water

"Improves rough skin effect"
Effective: Mostly rough skin was improved.
Slightly effective: Rough skin was slightly improved.
Invalid: No change before use.

(Test results)
As shown in Table 2, it was confirmed that the cream containing the artichoke extract, peony extract, loquat leaf extract, and lemon balm extract of the present invention significantly improved rough skin.

(Formulation example 3) Flexible lotion mass%
1.Glycerin 5.0
2.1,3-Butylene glycol 5.0
3.Polyoxyethylene sorbitan monolaurate (20E.O) 1.0
4.Ethanol 15.0
5. A: Artichoke extract of Production Example 5 B: Peonies extract of Production Example 5 C: Loquat leaf extract of Production Example 5 D: Lemon balm extract of Production Example 5 * Any one of A to D 5.0
6. Chamomile whole plant 60% 1,2-pentanediol extract 1.0
7. Antibacterial and antiseptic (paraoxybenzoic acid ester) appropriate amount
8. Fragrance (Western light water) appropriate amount
9. Residue with 100 purified water

(Formulation example 4) Pasta mass%
1. Flour 80.0
2.Bacon 15.0
3.Reiko 5.0
4. A: Artichoke extract of Production Example 1 B: Peonies extract of Production Example 1 C: Loquat leaf extract of Production Example 1 D: Lemon balm extract of Production Example 1 * Any one of A to D 5.0
5.Salt / Pepper appropriate amount
6.Butter proper amount
7.Green seaweed
8.Olive oil

(Formulation example 5) Beverage mass%
1.Glucose liquid sugar 30.0
2. Grapefruit juice 55.0
3. Artichoke extract dry powder of production example 1 5.0
4. Orange fruit hot water extract dry powder 5.0
5. Mucopolysaccharide solution 3.0
6. Iyokan Juice 2.0
7.Perfume appropriate amount
8. Suitable amount of acidulant

  The present invention contains a pro-opiomelanocortin expression inhibitor containing a specific plant extract (artichoke extract, peony extract, loquat leaf extract, lemon balm extract) as an active ingredient, or a specific plant extract thereof In addition, it is possible to provide a cosmetic composition and a food / beverage composition effective for improving stains, buckwheat, and rough skin.

Claims (6)

  A proopiomelanocortin expression inhibitor containing as an active ingredient at least one plant extract selected from artichoke extract, peony extract, loquat leaf extract, and lemon balm extract.   A proopiomelanocortin expression inhibitor caused by ultraviolet rays or stress containing at least one plant extract selected from artichoke extract, peony extract, loquat leaf extract, and lemon balm extract as an active ingredient.   A cosmetic composition comprising the pro-opiomelanocortin expression inhibitor according to claim 1.   A cosmetic composition comprising the pro-opiomelanocortin expression inhibitor resulting from ultraviolet rays or stress according to claim 2.   A food and beverage composition comprising the pro-opiomelanocortin expression inhibitor according to claim 1.   A food / beverage composition comprising the pro-opiomelanocortin expression inhibitor resulting from ultraviolet rays or stress according to claim 2.

Images