JP6025684B2 - Caspase-14 expression inducer by phenylethylamine derivative or synephrine - Google Patents

Description

  The present invention relates to a caspase-14 expression inducer containing a phenylethylamine derivative or synephrine as an active ingredient, and an application to a skin external preparation containing the caspase-14 expression inducer.

  The skin's original moisture retention deteriorates due to the effects of aging, ultraviolet rays, active oxygen, and the like, and the contractility and flexibility of the skin also decrease. Further, when the moisture retention of the skin is lowered, wrinkles are generated, the texture becomes rough, and the skin becomes dry and rough. Furthermore, it is very important in the healing method to increase the moisture retention of the skin even in the case of allergies or atopic dermatitis.

  Therefore, various components have been proposed in the past for obtaining a moisturizing effect on the skin. For example, a sorbitol derivative (Patent Document 1), glycerin (Patent Document 2), propylene glycol, dipropylene glycol or 1,3-butylene glycol (Patent Document 3), glycerin, sorbitol, maltitol and a mixture thereof (Patent Document 4) ) Etc. are used as moisturizers and wetting agents.

JP 5-25077 A JP-B 61-58445 Japanese Patent Publication 3-59042 Japanese Patent Publication 2-44283

  However, while the moisturizing agent and wetting agent described above are excellent in moisturizing action or moistening action, they have a sticky feeling when applied, and only show a temporary moisturizing effect or moistening effect. It did not produce an effect that would keep the skin moisturizing.

Therefore, NMF (natural moisturizing factor, hereinafter referred to as NMF), which is called a natural moisturizing factor, is a moisturizing substance indispensable for maintaining moisture in the skin. It has been reported that this NMF is produced when filaggrin produced by degradation of profilagrin secreted from keratohyalin granules in keratinocytes is degraded by an enzyme called caspase-14 (Non-patent Document 1). For this reason, it is considered that inducing caspase-14 promotes the production of NMF in the skin and remarkably improves the water retention capacity of the skin. In fact, in the skin of caspase-14 knockout mice, it has been shown that the amount of transdermal water transpiration (TEWL) is markedly increased and the amount of skin moisture is decreased (Non-patent Document 2).

The Journal of Investigative Dermatology Vol. 131, No. 11, 2233-2241, 2011 Nature Cell Biol. 9: 666-674, 2007

  From the above, rather than simply applying a moisturizing agent to the skin as in the prior art, by inducing caspase-14 present in the skin, the moisture content in the skin is maintained, leading to moist skin. Is considered useful.

  Then, although the substance, the extract, etc. which induce caspase-14 were investigated, they were not found.

  Therefore, the subject of this invention is providing the skin external preparation containing a novel and useful caspase-14 expression inducer and a caspase-14 expression inducer.

  Based on the above findings, the present inventor has made extensive studies on the theme of excellent natural substances that induce the expression of caspase-14.

  As a result, the present inventors have found that it has an action of inducing the expression of caspase-14 excellent in phenylethylamine derivatives or synephrine, and a caspase-14 expression inducer containing the phenylethylamine derivative or synephrine as an active ingredient, And the present invention was completed by providing the skin external preparation containing a caspase-14 expression inducer.

It is the figure which showed the caspase-14 protein expression level when adding the synephrine of this invention using Western Blotting method. As a control, a 70% 1,3-butylene glycol aqueous solution was prepared under the same conditions and used for the test.

The “synephrine” used in the present invention is 4- [1-hydroxy-2- (methylamino) ethyl] phenol, chemical formula: C ₉ H ₁₃ NO ₂ , molecular weight: 167.21, and a synthetic product has already been obtained. Although it is marketed, the extract from a natural product can also be used.

  As the shape of the phenylethylamine derivative or synephrine of the present invention used for producing the caspase-14 expression inducer or skin external preparation of the present invention, any shape such as liquid, solid, powder, paste, etc. In implementing the present invention, an optimum shape can be arbitrarily selected.

  The content of the phenylethylamine derivative or synephrine of the present invention in the caspase-14 expression inducer or skin external preparation of the present invention is not particularly limited as long as it can be confirmed to induce the expression of caspase-14, In general, the range of 0.001 mg / g to 200 mg / g (the denominator indicates the weight of the preparation) is preferable.

  As an external preparation for skin, for example, it can be used in various external preparations (including preparations used for animals) in general, specifically, ampoules, capsules, pills, tablets, powders, granules, solids, liquids, 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (eg lotion, Basic cosmetics such as milky lotion, cream, ointment, lotion, oil, pack, facial cleanser and skin cleanser, massage agent, cleansing agent, hair remover, hair remover, shaving treatment, after shave lotion, pre-show lotion , Shaving cream, foundation, lipstick, blusher, eyeshadow, eyeliner, mascara, makeup cosmetics, perfumes, nail polish, nail enamel, beauty nails Namel remover, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 4) medicinal and / or cosmetic preparations applied to the scalp and hair (eg shampoos, rinses, Hair treatment agent, pre-hair treatment agent, permanent liquid, hair dye, hair styling agent, hair styling agent, hair growth / hair conditioner, poultice, plaster agent, tape agent, sheet agent, patch, aerosol agent, etc.), 5) bath It can also be used for bathing agents used in hot water, 6) and other anti-smell and deodorants, deodorants, antiperspirants, hygiene products, sanitary cotton, and wet tissue.

  In addition, the caspase-14 expression inducer or external preparation for skin of the present invention is exemplified below in addition to the extract of each plant of the present invention which is an essential active ingredient, as long as the effects of the present invention are not impaired. Ingredients and additives can be selected and used in combination, and can be added with various functions. The content in the preparation is not particularly limited, but a concentration range of usually 0.0001 to 50% is preferable.

Pigmentation inhibitor A pigmentation inhibitor can be added to the present invention. Specific examples of pigmentation inhibitors include p-aminobenzoic acid derivatives, salicylic acid derivatives, benzenesulfonamide derivatives, imidazole derivatives, naphthalene derivatives, hydroxyanthranilic acid or salts thereof, and derivatives thereof, anthranilic acid derivatives, coumarin derivatives, amino acids Derivatives (2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid, 2-amino-3- [1-carboxyl-2- (1H-imidazole) -4-yl) ethyl] aminobutanoic acid hydrochloride, 2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid sodium salt, 2-amino-3- [ 1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid potassium salt, etc.), benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives Body, camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, ascorbic acid or its salt and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbine) Hydroxyprophosphate phosphate, 5-o-α-D-glucopyranosyl-L-ascorbic acid, L-ascorbate phosphate sodium salt, L-ascorbate phosphate potassium salt, L-ascorbate phosphate magnesium Salt, L-ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt L-ascorbic acid sulfate calcium salt, L-ascorbic acid sulfate aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid Aluminum salt, 6-o-α-D-galactopyranosyl-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L -Ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbine Acid phosphate ester isopropanolamine salt, 3-o-isopropyl-L-ascorbic acid, 6-o-alkyl ascorb Phosphoric acid ester potassium salt, 6-o-alkylascorbic acid phosphate calcium salt, 6-o-alkylascorbic acid phosphate barium salt, 6-o-alkylascorbic acid phosphate ammonium salt, 6-o -Alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl ascorbic acid phosphate diethanolamine salt, 6-o-alkyl ascorbic acid phosphate triethanolamine salt, 6-o-alkyl ascorbic acid phosphate ester Monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o- β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid Cholesterol acid ester, palmitic acid-L-ascorbyl, isopalmitic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl , Distearic acid-L-ascorbyl, diisostearic acid-L-ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethyl Hexanoic acid-L-ascorbyl, di-2-ethylhexanoic acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D- Maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L -Ascor Binic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitate, L-ascorbic acid tetralaurate, L-ascorbic acid tetra-2-ethylhexanoic acid Esters, L-ascorbic acid tetraoleate, 5,6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbine Acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2 -o-ascorbyl caffeate, 2-o-ascorbyl cinnamate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxyfe Lurate, DL-α-tocopherol-2-L-ascorbic acid diester, ascorbic acid inositol-conjugated derivative, ascorbic acid phosphoramide derivative, ascorbyl arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative Etc.), tocopherol or a salt thereof and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, toco Ferryl phosphate ester, tocopherol acetate, tocopherol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-to Ferryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ- Tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ -Tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L- β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1 -(Sulfoe Ruamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol, 1- (carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride , S- [3- (α-Tocopheryl-6-Iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-Tocopheryl-6-Iroxy) -2-hydroxypropyl] -γ- Glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxy Propyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, Cotrienol linoleate, tocotrienol orotate, etc.), tranexamic acid amide or a salt thereof, and derivatives thereof (trans-4-aminomethylcyclohexanecarbonamide, trans-4-aminomethylcyclohexanecarbonamide hydrochloride, Nn-hexyl-trans) -4-aminomethylcyclohexanecarbonamide, Nn-hexyl hydrochloride-trans-4-aminomethylcyclohexanecarbonamide, Nn-heptyl-trans-4-aminomethylcyclohexanecarbonamide, Nn-heptyl-trans hydrochloride -4-aminomethylcyclohexanecarbonamide, Nn-butyl-trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid Nn-butyl-trans-4-aminomethylcyclohexane Namide, Nn-propyl-trans-4-aminomethylcyclohexanecarbonamide, N-cyclohexyl-trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N-cyclohexyl-trans-4-aminomethylcyclohexanecarbonamide, N, N -Dicyclohexyl-trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N, N-dicyclohexyl-trans-4-aminomethylcyclohexanecarbonamide, N, N-diethyl-trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N, N -Diethyl-trans-4-aminomethylcyclohexanecarbonamide, N-benzyl-trans-4-aminomethylcyclohexanecarbonamide, N-benzyl-trans-4-a hydrochloride Nomethylcyclohexanecarbonamide, N- (4'-methoxyphenyl) -trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N- (4'-methoxyphenyl) -trans-4-aminomethylcyclohexanecarbonamide, N- ( 4'-ethoxyphenyl) -trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N- (4'-ethoxyphenyl) -trans-4-aminomethylcyclohexanecarbonamide, N- (2'-methylphenyl) -trans- 4-aminomethylcyclohexanecarbonamide, hydrochloric acid N- (2'-methylphenyl) -trans-4-aminomethylcyclohexanecarbonamide, N- (3'-methylphenyl) -trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N -(3'-methylphenyl) -trans-4-aminomethylcyclohexanecarbonamide, N- (4'-chlorophenyl) -trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N- (4'-chlorophenyl) -trans- 4-aminomethylcyclohexanecarbonamide etc.), kojic acid or derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2- Benzoluyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4 -On, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate , Kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.), oxybenzone, benzophenone, guaiazulene, shikonin, baicalin or salts thereof and derivatives thereof, baicalein Or salts thereof and derivatives thereof, berberine or salts thereof and derivatives thereof, chrysin or salts thereof and derivatives thereof, apigenin or salts thereof and derivatives thereof, luteolin or salts thereof and derivatives thereof, acacetin or salts thereof and the like Derivatives, diosmethine or a salt thereof and derivatives thereof, kaempferol or a salt thereof and derivatives thereof, triphorin or a salt thereof and derivatives thereof, astragalin or a salt thereof and These derivatives, quercetin or a salt thereof and derivatives thereof, quercitrin or a salt thereof and derivatives thereof, isoquercitrin or a salt thereof and derivatives thereof, rutin or a salt thereof and derivatives thereof, morin or a salt thereof and them Derivatives, myricetin or salts thereof and derivatives thereof, myristitrin or salts thereof and derivatives thereof, datiscetin or salts thereof and derivatives thereof, quercetagetin or salts thereof and derivatives thereof, isorhamnetin or salts thereof and derivatives thereof, pinocembrin Or salts thereof and derivatives thereof, naringenin or salts thereof and derivatives thereof, hesperetin or salts thereof and derivatives thereof, eriodictyol or salts thereof and derivatives thereof, pinobankin or salts thereof And derivatives thereof, aromadendrine or a salt thereof and derivatives thereof, engelitin or a salt thereof and derivatives thereof, taxofolin or a salt thereof and derivatives thereof, astilbine or a salt thereof and derivatives thereof, amperopsin or a salt thereof and a derivative thereof Derivatives, spiraeosides, kaempferol-7-neohesperidoside, glutathione or salts thereof and derivatives thereof, isoflavone glycosides (6-o-apiosyl puerarin-4'-o-glucoside, 6-o-glucosyl puerarin, 3'-hydroxypuerarin-4'-o-glucoside, 6-o-apiosyl-3'-hydroxypuerarin), γ-pyrone glycoside (maltol-3-o- (6'-o-apiosyl) -glucoside , Maltol-3-o- (6′-o-apiosyl) -glucoside, etc.), isononyl ferrate, ellagic acid or a salt thereof, and their Conductors (5,4-dimethylellagic acid, 3,3'-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-methoxyellagic acid, 3 -Ethyl-4-methyl-5-hydroxyellagic acid, amritoside, etc.), lucinol, ondisaponin, bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin, senegin, benzoic acid anilides (4-hydroxy-N- ( 2-hydroxyphenyl) benzoic acid amide, 4-hydroxy-N- (3-hydroxyphenyl) benzamide, 4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy -N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N- (3-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N -(2-hydroxyphenyl) benzamide, etc.), diphenyl Larin, cyproheptadine, triprolidine, dimethindene, ozagrel, isothipentyl, iproheptin, homochlorcyclidine, alimemazine, bucillamine, oxytosamide, vidarabine, xanthotoxol, phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide Water, zinc peroxide, placenta (bovine origin, porcine origin, horse origin, sheep origin, etc.) extract, almond extract, amaranth extract, octopus extract, lobster extract, querca extract, kofuyou extract, unca Rear extract, gaija extract, gypsophila extract, licorice extract, gardenia extract, cranigean extract, clara extract, koganebana extract, wheat (wheat) extract, rice (rice) extract, cori Aria extract, Sidwaya extract, Sankyu extract, Sanvitro extract, Sunpens extract, Silane (Biacyu) extract, Senkyu (river cucumber) extract, Senna extract, Senpukuka extract, Senktsusai extract, Surigatin extract, Nodake (maehu) Extract, pearl barley (Yokuinin) extract, hamago extract, honey beetle extract, hamamelis extract, palm extract, parietalia extract, safflower (safflower) extract, mugwa (mulberry bark) extract, malvanojadine (bitter) extract , Purple squirrels extract, white squirrels extract, mugwort mugwort extract, yashajitsu extract, hongkong extract, bituminous (soil) extract, quail lily extract, sorghum extract, millipede extract and the like.

Tyrosinase activity inhibitor A tyrosinase activity inhibitor can be added to this invention. Specific examples of tyrosinase activity inhibitors include ascorbic acid or a salt thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyprophosphate phosphate ascorbate, 5-o-α -D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid Sulfuric acid Stell aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyrano Sil-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Ester sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl- L-ascorbic acid, 6-o-alkylascorbic acid phosphate potassium salt, 6-o-alkylascorbic acid phosphoric acid Steal calcium salt, 6-o-alkyl ascorbic acid phosphate barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o-alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl Ascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanol Amine salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, phosphorus ascorbate Acid cholesterol ester, palmitic acid-L-ascorbyl, iso Lumic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid-L-ascorbyl, diisostearic acid-L- Ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid-L-ascorbyl, di-2-ethylhexane Acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α- D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-malto Triosyl-L-ascorbic acid, L-ascorbine Tetraisopalmitate, L-ascorbyl tetralaurate, L-ascorbate tetra-2-ethylhexanoate, L-ascorbate tetraoleate, 5,6-isopropylidene-L-ascorbate, L -Ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate , L-ascorbyl triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl ] -4'-acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphoric acid diester, Ascorbic acid inositol binding derivative, ascorbic acid phosphoramide derivative, ascorbic acid arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative, etc.), hydroquinone or its salt and derivatives thereof (hydroquinone α-D-glucose) , Hydroquinone β-D-glucose, hydroquinone α-L-glucose, hydroquinone β-L-glucose, hydroquinone α-D-galactose, hydroquinone β-D-galactose, hydroquinone α-L-galactose, hydroquinone β-L-galactose, etc. Hexoses, hydroquinone α-D-ribose, hydroquinone β-D-ribose, hydroquinone α-L-ribose, hydroquinone β-L-ribose, hydroquinone α-D-arabinose, hydroquinone β Five-carbon sugar glycosides such as -D-arabinose, hydroquinone α-L-arabinose, hydroquinone β-L-arabinose, hydroquinone α-D-glucosamine, hydroquinone β-D-glucosamine, hydroquinone α-L-glucosamine, hydroquinone β -Amino sugar glycosides such as L-glucosamine, hydroquinone α-D-galactosamine, hydroquinone β-D-galactosamine, hydroquinone α-L-galactosamine, hydroquinone β-L-galactosamine, hydroquinone α-D-glucuronic acid, hydroquinone β -D-glucuronic acid, hydroquinone α-L-glucuronic acid, hydroquinone β-L-glucuronic acid, hydroquinone α-D-galacturonic acid, hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, hydroquinone β-L -Hydroquinone coordination such as uronic acid glycosides such as galacturonic acid Body, hydroquinone benzyl ether, 4-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) butane, 5-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) pentane, 6-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) hexane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propane, 2-β-D- Hydroquinone hydroxyalkyl ether glycosides such as glucopyranosyloxy-1- (4-hydroxyphenoxy) butane and 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propan-3-ol ), Kojic acid or a salt thereof and derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoluyloxy Methyl-5-hydroxy-4H-pyran-4-one, 2-cin Moyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate , Kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.), tocopherol or salts thereof and Derivatives (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, Coferol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside Sid, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl Maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-to Ferryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, L- (sulfoethylamino) -3- (α-tocopheryl-6-iroxy) Propan-2-ol, 1- (carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) ) -2-Hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl) -6-Iroxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α -Tocotrienol, β-Tocotrienol, γ-Tocotrieno , Δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate, etc.), N-acetyltyrosine or a salt thereof and derivatives thereof, glutathione or a salt thereof and derivatives thereof, ellagic acid Or a salt thereof and a derivative thereof (3,4-dimethylellagic acid, 3,3′-dimethylellagic acid, 3,3 ′, 4-trimethylellagic acid, 3,3 ′, 4,4′-tetramethyl-5 -Methoxyellagic acid, 3-ethyl-4-methyl-5-hydroxyellagic acid, amritoside, etc.), isonitrine A, isonitrine B, isonitrine C, isonitrine D, isonitrinic acid E, isonitrinic acid F, dermadein, tricobylidein, etc. Isonitrile antibiotics, orselinic acid derivatives (orceric acid, orthoselic acid ethyl Ester orcinol, p-geranyl orthoselic acid, p-geranyl orthoselic acid ethyl ester geranyl orcinol, p-farnesyl orthoselic acid, p-farnesyl orthoselic acid ethyl ester farnesyl orcinol, p-dodecanyl orthoseric acid, p-dodecanylorceric acid ethyl ester dodecanylorcinol, p-tetradecanylorceric acid, p-tetradecanylorceric acid ethylester tetradecanylorcinol, p-hexadecanylorceric acid, p- Hexadecanylorceric acid ethyl ester Hexadecanylorcinol, p-undecanylorceric acid, p-undecanylorceric acid ethyl ester undecanylorcinol, p-tridecanylorceric acid, p-tri Decanylorceric acid ethyl ester undecanylorcinol, p- Pentadecanylorceric acid, p-pentadecanylorceric acid ethyl ester pentadecanylorcinol, ethylhexylorceric acid, p-ethylhexylorceric acid ethylester ethylhexylorcinol, p-cyclohexylmethylorceric acid, p- Cyclohexylmethylorceric acid ethyl ester cyclohexylmethylorcinol, p-hydroxyethylhexylorceric acid methyl ester, p-hydroxyethylhexylorceric acid hydroxyethylhexylorcinol, etc.), umbelic acid, brefeldin, oxydesveratrol, resorcinol derivatives (4-cyclohexylresorcinol), 3-hydroxyketone compounds (1,5-bis (p-hydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (o, p-dihydroxypheny) ) -2-hydroxypentan-4-one, 1,5-bis (p-hydroxyphenyl-m-methoxyphenyl) -2-hydroxypentan-4-one, etc.), 1,3-diketone compound (1,5- Bis (p-hydroxyphenyl) -2,4-pentanedione, 1,5-bis (o, p-dihydroxyphenyl) -2,4-pentanedione, 1,5-bis (p-hydroxyphenyl-m-methoxy) Phenyl) -2,4-pentanedione), bishydroxybenzyl amides, γ-aminobutyric acid or its derivatives (N-methyl-γ-aminobutyric acid, N-dimethyl-γ-aminobutyric acid, γ-aminobutyric acid oleyl ester) Etc.), Hydrogen peroxide, Zinc peroxide, Placenta extract, Lucinol, Silk extract, Acacia extract, Acerola extract, Ichibi (winter position) extract, Inula racemosa extract, Weeping birch extract, Quercus extract, Chestnut extract , Kamehiba kokoshi extract Black-bellied toad extract, senshinren (Pinced lotus) extract, seri extract, buckwheat extract, dabilia extract, nazuna extract, Fujibaka extract (Orchid grass) extract, chamomile extract, mulberry extract, gardenia extract, red snapper extract, bitumen extract, clara extract, mugwort extract, honeysuckle extract, yellowfin Extract, Bokudami extract, Matsuhodo extract, pearl barley extract, nettle extract, hop extract, hawthorn extract, eucalyptus extract, yarrow extract, altea extract, cinnamon extract, bay extract, hamameris extract, yamagwa extract, bellflower extract, toshishi extract Extract, sprayed extract, maize extract, senkyu extract, dokkatsu extract, psycho extract, boufu extract, kingfish extract, oxon extract, peony Examples include peel extract, peony extract, geno shoko extract, kudzu root extract, licorice extract, pentaploid extract, aloe extract, shouma extract, safflower extract, green tea extract, black tea extract, and asen drug extract.

Melanocyte Melanin Production Inhibitor A melanocyte melanin production inhibitor can be added to the present invention. Specific examples of melanocyte melanin production inhibitors include lobeline or lobeline derivatives, liquiritin derivatives (such as liquiritin-α-glucoside, liquiritin-α-maltoside), phenylchroman derivatives, chromone derivatives (2-butylchromone, 2-pentylchromone, 2 -Heptylchromone, 2-nonylchromone, 2-hexadecylchromone, 2- (1-ethylpentyl) chromone, 2-butyl-7-methoxychromone, 2-pentyl-7-methoxychromone, 2-heptyl-7-methoxychromone , 2-nonyl-7-methoxychromone, 2-pentadecyl-7-methoxychromone, 2- (1-ethylpentyl) -7-methoxychromone, 7-hydroxy-2-methylchromone, 7-hydroxy-2-butylchromone 7-hydroxy-2-pentylchromone, 7-hydroxy-2-heptylchromone, 7-hydroxy-2-nonylchromone, 7-hydroxy -2-pentadecylchromone, 7-hydroxy-2- (1-ethylpentyl) chromone), azelaic acid derivatives (eg azelaic acid monoalkyl ester, azelaic acid dialkyl ester), phosphatidylglucosamine, lysophosphatidylglucosamine, phenylhydroquinone 3-β-D-glucopyranosyl manur, 3-β-D-maltopyranosyl manur, substituted amino acid derivatives (DL-N-formyl-3- (1-naphthyl) alanine, DL-N-acetyl-3 -(1-naphthyl) alanine, DL-N-propionyl-3- (1-naphthyl) alanine, DL-N-butyryl-3- (1-naphthyl) alanine, DL-N-isobutyryl-3- (1-naphthyl) ) Alanine, DL-N-valeryl-3- (1-naphthyl) alanine, DL-N-isovaleryl-3- (1-naphthyl) alanine, DL-N- (2-methylvaleryl) -3- (1-naphthyl) Alanine, DL-N- (3-Methylvaleryl) -3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine, DL-N-t-butylacetyl-3- (1-naphthyl) alanine, DL-N-pivaloyl- 3- (1-naphthyl) alanine, DL-N-caproyl-3- (1-naphthyl) alanine, DL-N- (2-ethylhexanoyl) -3- (1-naphthyl) alanine, DL-N- ( 2-methylhexanoyl) -3- (1-naphthyl) alanine, DL-N-heptanoyl-3- (1-naphthyl) alanine, DL-N-octanoyl-3- (1-naphthyl) alanine, DL-N- (2-propylpentanoyl) -3- (1-naphthyl) alanine, DL-N-nonanoyl-3- (1-naphthyl) alanine, DL-N-decanoyl-3- (1-naphthyl) alanine, DL-N -Undecanoyl-3- (1-naphthyl) alanine, DL-N-dodecanoyl-3- (1-naphthyl) alanine, DL-N-tridecanoyl-3- (1-naphthyl) alanine, DL-N-tetradecanoyl- 3- (1-Naph ) Alanine, DL-N-pentadecanoyl-3- (1-naphthyl) alanine, DL-N-hexadecanoyl-3- (1-naphthyl) alanine, DL-N-heptadecanoyl-3- (1-naphthyl) ) Alanine, DL-N-octadecanoyl-3- (1-naphthyl) alanine, DL-N-nonadecanoyl-DL-3- (1-naphthyl) alanine, DL-N-icosanoyl-3- (1-naphthyl) Alanine, DL-N-Acroyl-3- (1-naphthyl) alanine, DL-N-crotoniloyl-3- (1-naphthyl) alanine, DL-N-methacryloyl-3- (1-naphthyl) alanine, DL-N -Vinylacetyl-3- (1-naphthyl) alanine, DL-N-cyclopropanoyl-3- (1-naphthyl) alanine, DL-N- (2-pentenoyl) -3- (1-naphthyl) alanine, DL -N- (4-pentenoyl) -3- (1-naphthyl) alanine, DL-N- (2-hexenoyl) -3- (1-naphthyl) alanine, DL-N- (3-hexenoyl) -3- ( 1-naphthyl) Lanin, DL-N- (2-Methyl-3-pentenoyl) -3- (1-naphthyl) alanine, DL-N-cyclohexenoyl-3- (1-naphthyl) alanine, DL-N- (10 -Undecenoyl) -3- (1-naphthyl) alanine, DL-N-linoleyl-3- (1-naphthyl) alanine, DL-N-hydroxyacetyl-3- (1-naphthyl) alanine, DL-N- (6 -Hydroxycaproyl) -3- (1-naphthyl) alanine, DL-N- (8-hydroxyoctanoyl) -3- (1-naphthyl) alanine, DL-N- (9-hydroxynonanoyl) -3- (1-naphthyl) alanine, DL-N- (10-hydroxydecanoyl) -3- (1-naphthyl) alanine, DL-N- (11-hydroxyundecanoyl) -3- (1-naphthyl) alanine, DL-N- (12-hydroxydecanoyl) -3- (1-naphthyl) alanine, DL-N-benzoyl-3- (1-naphthyl) alanine, DL-N- (2-hydroxybenzoyl) -3- ( 1-naphthyl) arani DL-N- (3-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (4-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (o-toluyl) ) -3- (1-naphthyl) alanine, DL-N- (m-toluyl) -3- (1-naphthyl) alanine, DL-N- (p-toluyl) -3- (1-naphthyl) alanine, DL -N- (1-naphthoyl) -3- (1-naphthyl) alanine, DL-N- (2-naphthoyl) -3- (1-naphthyl) alanine, DL-N- (2-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (4-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N -(2-Picoloroyl) -3- (1-naphthyl) alanine, DL-N- (3-Picoloroyl) -3- (1-naphthyl) alanine, DL-N- (4-Picoloroyl) -3- (1- Naphthyl) alanine, DL-N-phenylacetyl-3- (1-naphthyl) arani DL-N- (2-phenylpropanoyl) -3- (1-naphthyl) alanine, DL-N- (3-phenylbutyryl) -3- (1-naphthyl) alanine, DL-N- (4 -Methylvaleryl) -3- (1-naphthyl) alanine, DL-N-valeryl-3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanineamide, DL- N- (4-methylvaleryl) -3- (1-naphthyl) alanine methyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine ethyl ester, DL-N- (4-methylvaleryl)- 3- (1-naphthyl) alanine propyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine-N-butyl ester, DL-N- (4-methylvaleryl) -3- (1- Naphthyl) alanine pentyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine isopropyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) ) Alanine isobutyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine-t-butyl ester, etc.), benzolactam derivatives, indolactam derivatives, cedrol, guaioles, 1- (4-hydroxypheny Thio) -2-propanol, β-lactoglobulin, 2-methoxy-5-methylphenol, 5-ethyl-2-methoxyphenol, 5-N-propyl-2-methoxyphenol, 5-N-butyl-2-methoxy Phenol, 5-N-hexyl-2-methoxyphenol, 5-N-heptyl-2-methoxyphenol, 5-N-decyl-2-methoxyphenol, 5- (1,1-dimethylpropyl) -2-methoxyphenol , 5- (1,1-dimethylbutyl) -2-methoxyphenol, 5- (1,1-dimethylethyl) -2-methoxyphenol, 2-methoxy-5- (1-methylpentyl) phenol, 2-methoxy -5- (1-Methylhexyl) pheno 2-methoxy-5- (3-methylhexyl) phenol, 2-methoxy-5- (6-methylheptyl) phenol, 5- (1,3-dimethylheptyl) -2-methoxyphenol, malvelin, ferruginol, Sugiol, cryptojaponol, 1,5-bis [p-hydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [o-hydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [2,4-dihydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [3-methoxy-4-hydroxyphenyl] -1,4-pentadien-3-one , Haginin, agrimophor, agrimol, hydrangenol or derivatives thereof, alkylresorcinol or derivatives thereof (such as 4-N-butylresorcinol), aristrone, caramenenes (caramenene, 7-hydroxycaramenene, 5-hydroxycaramenene, 7-methoxycaramenene ), Trans-umberic acid, N-α-benzoyl-L-arginine, N-α-benzoyl-L-arginine ethyl ester or N-α-benzoyl-L-arginine ethyl ester, 5-methyl-2 (3H)- Furanone, 2-butene-4-olide, 2-hydroxymethylfuran, 2,5-dimethyl-4-hydroxy-3 (2H) -furanone, 2-formylfuran, 3-formylfuran, methyl α-furyl ketone, furfuryl Acetate, 2-hydroxy-3-methyl-2-cyclopenten-1-one, 2-hydroxy-3,5-dimethyl-2-cyclopenten-1-one, 2,5-dimethyl-4-hydroxy-3 (2H) -Thiophenone, 2-hydroxy-3-ethyl-2-cyclopenten-1-one, tetronic acid, pentanedione, iminodibenzyls (2,2'-iminodibenzyl, imipramine, imipramine hydrochloride, desipramine, desipramine hydrochloride , Chlorimipramine, trimipura Min), dibenzocycloheptadiene (amitriptyline, amitriptyline hydrochloride, nortriptyline, noxypetitin, etc.), tetrahydrocopalol glycoside (ketotifen fumarate, labda-8 (17), 13-dien-15-ol, tetrahydroma Nour, tetrahydrocoparol, tetrahydrocoparol glucoside, tetrahydrocoparol galactoside, tetrahydrocoparol maltoside, tetrahydrocoparol cellobioside, tetrahydrocoparol maltotrioside, etc.), spiro ether compound, piochelin, phenothiazine compound, promethazine, alimemazine , Alimemazine tartrate, triflupromazine, levomepromazine, chlorpromazine, cyclandrate, 4-carboxymethyloxybenzoic acid, 4-carboxymethyloxy 2-hydroxybenzoic acid, 3- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) benzoic acid, 4- (3-carboxypropyl-1 -Oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-methoxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2 -Hydroxybenzoic acid, 4- (10-carbamoyldecane-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) benzoic acid, 4- (4-hydroxybutyl-1-oxy) ) -2-Hydroxybenzoic acid, 4- (4-acetoxybutyl-1-oxy) benzoic acid, 4- (4-acetoxybutyl-1-oxy) -2 -Hydroxybenzoic acid, 4- (3-ethoxycarbonylpropyl-1-oxy) -2-hydroxybenzoic acid, 3- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (4 -Methoxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2 -Hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl) -1-oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid Benzoic acid, hydroxytrimethylcyclohexanes (2-hydroxy-4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane)- 1-butene, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2-butene, 4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 3-methyl-3 -Hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3 -Methyl-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -3- Pentene, 3-methyl-3-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -1-pentene, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl 1-yl-cyclohexa ) -2-pentene, 2-hydroxy-4- (2,2,6-trimethyl-1-yl-cyclohexane) butane and other monosaccharides, disaccharides or trisaccharide glycosides), escinol, parahydroxycinnamic acid -4- (2,2,6-trimethyl-yl-cyclohexane) -2-butyl ester monosaccharide, disaccharide or trisaccharide glycoside, ondisaponin, bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin , Senegin, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2-keto-butane, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto -Butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2-keto-3-butene, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2 -Keto-3-butene (β-ionone), Lp-hydroxyphenylglycine, Dp-hydroxyphenylglycine, N-benzyloxycarbonyl-Lp-hydroxy Phenylglycine, N-benzyloxycarbonyl-Dp-hydroxyphenylglycine, N-benzoyl-Lp-hydroxyphenylglycine, N-benzoyl-Dp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Dp-hydroxyphenylglycine, N- (p-hydroxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-hydroxybenzoyl) -Dp-hydroxyphenylglycine, N-acetyl-Lp -Hydroxyphenylglycine, N-acetyl-Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine ethyl ester, N-acetyl-Dp-hydroxyphenylglycine ethyl ester, N-acetyl-Lp-hydroxyphenylglycinamide, N-acetyl-Dp-hydroxyphenylglycinamide, Lp- Toxiphenylglycine, Dp-methoxyphenylglycine, Lp-methoxyphenylglycine hydrochloride, Dp-methoxyphenylglycine hydrochloride, 4-hydroxy-3-methoxy-L-phenylglycine, 4-hydroxy-3-methoxy-D-phenyl Glycine, Lp-hydroxyphenylglycine ethylamide, Dp-hydroxyphenylglycine ethylamide, N-tert-butoxycarbonyl-Lp-hydroxyphenylglycine, N-tert-butoxycarbonyl-Dp-hydroxyphenylglycine, N-tert-butoxycarbonyl -Lp-methoxyphenylglycine, N-tert-butoxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Dp- Methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-L p-methoxyphenylglycine benzyl ester hydrochloride, N-9-fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine benzyl ester hydrochloride, Lp-hydroxyphenylglycinamide, Dp-hydroxyphenylglycinamide, Lp-hydroxyphenylglycine Allyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine allyl ester p-toluenesulfonate, Lp-hydroxyphenylglycine benzyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine benzyl ester p-toluenesulfonate Lp-hydroxyphenylglycine ethyl ester, Dp-hydroxyphenylglycine ethyl ester, Lp-hydroxyphenylglycine ethyl ester hydrochloride, Dp-hydroxyphenylglycine ethyl ester hydrochloride, Lp- Roxyphenylglycine methyl ester, Dp-hydroxyphenylglycine methyl ester, etc. Spiroketal derivatives (2- (2,4-hexadinylidene) -1,6-dioxaspiro [4.5] dec-3-ene, 2- (2-hexynylidene) -1,6-dioxaspiro [4.4] non-3-ene 2-((4-methylphenyl) methylidene) -6,6-dioxaspiro [4.4] non-3-ene, 2- (2-hexenylidene) -6,6-dioxaspiro [4.5] dec-3-ene, 2 -(2-hexenylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-hexyl-1,6-dioxaspiro [4.4] nonane, 2- (2-hexenyl) -1,6-dioxaspiro [4.4 ] Nonane, 2- (2-hexynyl) -1,6-dioxaspir [4] nonane, 2-pentyl-1,6-dioxaspiro [4.4] nonane, 1,6-dioxaspiro [4.4] nonane, 1,6-dioxaspiro [4.5] decane, 1,7-dioxaspiro [5.5] undecane, 2,3-benzo-4,4-dimethyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-pentyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2- Hexyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-octyl-1,6-dioxaspiro [4.4] nonane, 2-hexyl-9,9-dimethyl-1,6-dioxaspiro [4.4] Nonane, 2- (2,4-hexadiniylidene) -1,6-dioxaspiro [4.4] non-3-ene, etc.), malvalic acid, phosphonic acid derivative or salt thereof, aspergillomarasmine, aminophosphonic acid derivative or Its salt, diphenhydramine or its salt, pregnenolone or its derivative, lutein, farnesyl isopropanol derivative, hexahydrophal Silacetone, 4-benzoylamino-2-hydroxybenzoic acid, 5-benzoylamino-2-hydroxybenzoic acid, 4-benzoylaminobenzoic acid, 4- (1-naphthoylamino) -2-hydroxybenzoic acid, 5- ( 1-naphthoylamino) -2-hydroxybenzoic acid, 4- (2-naphthoylamino) -2-hydroxybenzoic acid, 5- (2-naphthoylamino) -2-hydroxybenzoic acid, 4- (1- Naphthoylamino) benzoic acid, 4- (2-naphthoylamino) benzoic acid, 4-phenylaminocarbonylbenzoic acid, 4-phenylaminocarbonyl-2-hydroxybenzoic acid, 5-phenylaminocarbonyl-2-hydroxybenzoic acid 4- (1-naphthylaminocarbonyl) benzoic acid, 4- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 4- (2- Naphthylaminocarbo E) Benzoic acid, 4- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, hexahydrofarnesyl isopropanol derivative, borneol-p-hydroxycinnamic Acid ester glucoside, borneol-p-hydroxycinnamic acid maltoside, borneol-p-hydroxycinnamic acid maltotrioside, cinnamic acid-4- (2,2,6-trimethyl-yl-cyclohexane) -2- Butyl ester derivatives, 2,4-dihydroxybenzophenone, 1- (2,4-dihydroxyphenyl) -ethanone (2 ', 4'-dihydroxyacetophenone), 1- (2,4-dihydroxyphenyl) -1-propanone (2 ', 4'-dihydroxypropiophenone), 1- (2,4-dihydroxyphenyl) -1-butanone, 1- (2,4-dihydroxyphenyl) -1-pentanone, 1- ( 2,4-dihydroxyphenyl) -1-hexanone, 1- (2,4-dihydroxyphenyl) -1-heptanone, 1- (2,4-dihydroxyphenyl) -1-octanone, 1- (2,4-dihydroxy Phenyl) -1-nonanone, 1- (2,4-dihydroxyphenyl) -1-decanone, 1- (2,4-dihydroxyphenyl) -1-undecanone, 1- (2,4-dihydroxyphenyl) -1- Dodecanone, 1- (2,4-dihydroxyphenyl) -1-tetradecanone, 1- (2,4-dihydroxyphenyl) -1-hexadecanone, 1- (2,4-dihydroxyphenyl) -1-octadecanone, 1- ( 2-hydroxy-4-methoxyphenyl) -ethanone (2'-hydroxy-4'-methoxyacetophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-propanone (2'-hydroxy-4'-methoxy) Propiophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-butanone, 1- (2-hydroxy-4) -Methoxyphenyl) -1-pentanone, 1- (2-hydroxy-4-methoxyphenyl) -1-hexanone, 1- (2-hydroxy-4-methoxyphenyl) -1-heptanone, 1- (2-hydroxy- 4-methoxyphenyl) -1-octanone, 1- (2-hydroxy-4-methoxyphenyl) -1-nonanone, 1- (2-hydroxy-4-methoxyphenyl) -1-decanone, 1- (2-hydroxy -4-methoxyphenyl) -1-undecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-dodecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-tetradecanone, 1- (2- Hydroxy-4-methoxyphenyl) -1-hexadecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octadecanone, 1- (4-hydroxy-2-methoxyphenyl) -ethanone (4′-hydroxy-2 '-Methoxyacetophenone), 1- (4-hydroxy-2-methoxyphenyl) -1-propanone (4'- Droxy-2'-methoxypropiophenone), 1- (2,4-dimethoxyphenyl) -ethanone (2 ', 4'-dimethoxyacetophenone), 1- (2,4-dimethoxyphenyl) -1-propanone (2 ', 4'-dimethoxypropiophenone), lactone derivatives (1,6-dioxaspiro [4.4] nonane-2,7-dione, 1,6-dioxaspiro [4.5] decane-2,7-dione, 4-tridecanolide, 4-dodecanolide, 4-undecanolide, 4-decanolide, 4-nonanolide, 4-octanolide, 4-heptanolide, 5-dodecanolide, 5-undecanolide, 5-decanolide, 5-nonanolide, 5-octanolide, 2-undecen-4- Orido, 2-Decene-4-Olide, 2-Nonene-4-Olide, 2-Heptene-4-Olide, 2-Undecen-5-Olide, 2-Decene-5-Olide, 2-Nonene-5-Olide, 2-octene-5-olide, 4-methyl-4-dodecanolide, 4-methyl-4-undecanolide, 4-methyl-4-de Nolide, 4-methyl-4-nonanolide, 4-methyl-4-heptanolide, 5-methyl-5-dodecanolide, 5-methyl-5-undecanolide, 5-methyl-5-decanolide, 5-methyl-5-nonanolide, 5-methyl-5-octanolide, 2-methoxycarbonyl-4-dodecanolide, 2-methoxycarbonyl-4-undecanolide, 2-methoxycarbonyl-4-decanolide, 2-methoxycarbonyl-4-nonanolide, 2-methoxycarbonyl-4 -Heptanolide, 2-methoxycarbonyl-5-undecanolide, 2-methoxycarbonyl-5-decanolide, 2-methoxycarbonyl-5-nonanolide, 2-methoxycarbonyl-5-octanolide, 2-allyl-4-undecanolide, 2-allyl -5-decanolide, 2-allyl-4-nonanolide, 2-pentyl-4-undecanolide, 2-pentyl-4-nonanolide, 2-methyl-4-undecanolide, 2-methyl-4-nonanolide, 2- (4- Hydroxybuty ) -4-undecanolide, 2- (4-hydroxybutyl) -4-nonanolide, 2- (4-hydroxybutyl) -5-decanolide, 5-propyloxy-4-pentanolide, 5-allyloxy-4-pentanolide, 5- (2-hydroxyethoxy) -4-pentanolide, 8-hydroxy-4-octanolide, 6-propyloxy-5-hexanolide, 6-allyloxy-5-hexanolide, 6- (2-hydroxyethoxy) -5-hexanolide , 9-hydroxy-5-nonanolide, etc.), ethinomycin, iriflorental, iriparidal, 2'-8-C-glucosyl-7-methylaloesol coumaroyl ester, 2'-8-C-glucosyl-7-methyl Aloesol cinnamoyl ester, chloropyramine, anise extract, aloe extract, Japanese knotweed extract, seaweed extract, shrimp extract, Ketsumeishi extract, ogi Kisses, yellow-tailed sea urchin extract, red-crowned cucumber (calocon) extract, red fir tree extract, white-faced yam extract (Tempa) extract, oyster extract, red-footed duck extract, yak extract, pumpkin extract, gamma (yellow) extract, kansui extract , Kimihiki (Sentsukakusa) extract, Black-bellied extract, Black-spotted extract, Sisal (Sisal Asa) extract, Saxima button leopard extract, Chinese peony extract, Chinese pear extract (Wei Sensen) extract, Oshima cherry extract, Oyama cherry extract, Bean cherry extract, Takane cherry Extract, Kohigan extract, Sato cherry extract, Zion (purple cocoon) extract, palm extract, white squirrels extract, ginseng (large persimmon) extract, corn shiba (hot pepper) extract, daimon ginseng extract, tsukimisoue , Toshishi extract, bean pod extract, pear extract, sagebrush extract, yarrow extract, cassava extract, dill extract, honey beetle extract, terrestris extract, human camellia extract, stag beetle extract, beetle extract, floral Blanka extract, Hermula extract, Syringa extract, Convolvulaceae extract, Sandalwood extract, Mannentake (Ganoderma biloba) extract, Mejijiki (benuse) extract, Chinese willow extract, Japanese red willow extract, Japanese willow extract, Japanese willow extract, Japanese willow extract, Unryu willow extract Extract, Miyama willow extract, Willow willow extract, Great willow willow extract, Tirikkinu willow extract, Fox willow extract, Dronoki extract, Yam Plum skin) extract, agave extract, aolan agave extract, fuchrin agave extract, mitsumata extract, aonori extract, usba aonori extract, sugiaonori extract, hiraaonori extract, bouaoonori extract, hosoeda aonori extract, kombu extract, silicon extract , Hosomomebu extract, Mitsushi Kombu extract, Wakame extract, Hirome extract, Aowakame extract, Hijiki extract, Hibamata extract, Umichiwa extract, Usubamichichiwa extract, Kirebano miwiwa extract, Akabami michiwa extract, Kona miwiwa extract, Okinawachiwa extract Extracts, Etsumiumichiwa Extract, Spikeling Rhinoceros Extract, Amakusa Rhinoceros Extract, Giraffe Rhinoceros Extract, Sandalwood Giraffe Rhinoceros Kiss, Tsunomata Extract, Ibottsu no Mata Extract, Marubat Nomata Extract, Hirakotoji Extract, Sugi nori Extract, Shikinori Extract, Kainori Extract, Yakuzusa Extract, Urabo Shiyahaz Extract, Sea Urchin Extract, Ishimozuku Extract, Misjikonbu Extract, Atsuba Misikobu Extract, Isomok Extract Nagashima Moku Extract, Shida Moku Extract, Nesamoku Extract, Narasamo Extract, Mametawala Extract, Tatsukuri Extract, Yatsuma Tamoku Extract, Umitorano Extract, Oba Moku Extract, Fusiform Moku Extract, Haha Moku Extract, Yoremo Moku Extract, Saw Memox Extract, Obanoko Kiri Mokuri Mokura , Cronouraxa extract, Parrot caenade extract, Pine tree extract, Paragonori extract, Sponge extract, Fu Tuna extract, Japanese puffer tree extract, Hiroha Fushitsugi extract, Kurosozo extract, Kobuzozo extract, Shirozozo extract, Sozonohana extract, Sake mushroom extract, Thira extract, Camote de afuran extract, Hamica extract, Polo verde extract, Nabonegro extract, Korean sengo Misi extract, Matsubusa extract, Binankazura extract and the like.

Melanin production promoter A melanin production promoter can be added to the present invention. Specific examples of the melanin production promoter include salicylic acid or a salt thereof and derivatives thereof (salicylic acid glucoside, salicylic acid fatty acid ester, salicylic acid alcohol ether, salicylic acid amides, etc.), salicyl alcohol or a salt thereof and derivatives thereof, apigenin, and amentoflavone. , Salamander Extract, Udo Extract, Shishido Extract, Nilin Sou Extract, Oak Extract, Beef Taxi Extract, Cuckoo Thistle Extract, Gypsophila Extract, Gymnema Sylvestre Extract, Karo Oyster Extract, Ginkgo Kinca Extract, Konronka Extract, Sabin Ryo Extract, Jasmine (pine licorice) extract, hollyhock extract, scallop extract, Arabidopsis extract, lily of the valley extract, sawnose extract, deco extract, tochu , Nagii Kada (Butcher Bloom) extract, Teppo cucumber extract, Tokiwa Mansaku extract, Nankin goat extract, Elderflower extract, Nadeshiko extract, Michiyanagi extract, Japanese willow extract, Morohaya extract Tamazaki wisteria extract, Ryokaou extract, Amijigusa extract, shellfish extract (cockle extract, green mussel extract, oyster extract, European oyster extract, scallop extract, clam extract, clam extract, bakagai extract, isoyster mussel extract, red oyster extract, abalone extract , Sazae extract, bi-extract, etc.).

Humectant A humectant can be added to the present invention. Specific examples of moisturizers include gum arabic, benzoin rubber, danmar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum, carob gum, quince seed, agar or its derivatives, casein, glucose, galactose, mannose, xylose, fructose, maltose, iso Maltose, cellobiose, gentiobiose, trehalose, cordierbiose, laminaribiose, nigerose, sambubiose, neohesperidose, apiose, hammamellose, streptose, hydroxystreptose, dihydrostreptose, 2-methylerythrose or derivatives thereof, 2-methylerythrono Lactone, micalose, cladinose, accessose, alkanose, olivomai course, chromose, ebamise, vinerose , Sugars such as nogarose, bilenose, nobiose, moenuronic acid, galosamine, cybirosamine, N-acylcansosamine, vancosamine, evanitrose, rubranitrose, tetronitrose, pyralose, α-octose, trioxacalcinose, aldgarose, blastminosin 1,3-butylene glycol, glycerin, propylene glycol, polyethylene glycol, dipropylene glycol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,6-hexanediol, mannitol and Sorbitol, ethanediol, diethylene glycol, triethylene glycol, 2-amino-2-methyl-1,3-propanediol, 1,2-propanediol, 1,3-propanediol, polypropylene glycol, 1,2-butyl Diol, 1,3-butanediol, 1,4-butanediol, isopentanediol, pentylene glycol, hexylene glycol, 1,3-pentanediol, 1,4-pentanediol, 1,2,3-pentanetriol, 2,3,4-pentanetriol, 1,3,4-pentanetriol, 1,3,5-pentanetriol, 1,3-hexanediol, 1,4-hexanediol, 1,5-hexanediol, 1, 2,3-hexanetriol, 1,3,4-hexanetriol, 1,3,5-hexanetriol, 1,4,6-hexanetriol, erythritol, pentaerythritol, dipentaerythritol, threitol, arabitol, xylitol, Ribitol, galactitol, lactitol, maltitol, inositol, panthenol, laminitol, valienamine, validamine, validatitol, trehalose Is a derivative thereof, D-mannosamine and a derivative thereof, isomaltoligosaccharide (panose), primeverose or a derivative thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, alkylene (C2 to C4) oxide such as ethylene oxide Hydroxyalkyl (C2-C4) chitin or chitosan to which is added, low molecular chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or Its salts, β-1,3-glucan, β-1,4-glucan, β-1,6-glucan, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose, carboxyethylcellulose, sodium carboxyethylcellulose, Roxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, hydroxypropyl methylcellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide, or cross-linking polymerization thereof Water-soluble polymers such as carboxyvinyl polymer, polyethyleneimine, dermatan sulfate, keratan sulfate, glycerin fatty acid pyrrolidone carboxylic acid ester, glycerin fatty acid acetyl amino acid ester, pyrrolidone carboxylic acid or salt thereof, polyaspartic acid or salt thereof Polyglutamic acid or a salt thereof, polylysine or a salt thereof, sodium lactate, hydantoin and Its derivatives, Np-vinylbenzyl-D-cellobionamide, Np-vinylbenzyl-D-lactone amide, Np-vinylbenzyl-D-maltonamide, Np-vinylbenzyl-D-gluconamide, glucosyloxyethyl methacrylate, galactosyl Oxypropyl acrylate, mannosyloxyethyl methacrylate, glutamyl lysine, glutaurine, 1,2,4-butanetriol, caran-3,4-diol, azoxaponin (3-o- [β-D-glucopyranosyl-β-D-glu Chronopyranosyl] -sophoradiol, 3-o- [β-D-glucopyranosyl-3-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D -Glucuronopyranosyl] -azuxapogenol, 3-o- [β-D-glucopyranosyl] -28-o- [β-D-glucopyranosyl-β-D-glucopyranosyl] -dipsogenic acid, 3-o- [α-L-Rhamnopyranosyl-β-D-G Lucopyranosyl-β-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -29-o- [β-D- Glucopyranosyl-β-D-glucopyranosyl] -azuxapogenol, etc.), Aoki (Aoki) extract, Aogiri extract, Kenashia Ogiri (Akatsuki) extract, Red clover extract, Red clover extract, Akikara pine extract, Aguahe (Omitenga palm) extract , Maruba morning glory extract, morning glory extract, athira (shokuyo kanna) extract, oilseed rape extract, amachazul extract, amana extract, sunfish extract, hagateto extract, scallop extract, garlic extract, sugimorige Ito extract, Hosoa Otome extract, Aogateto extract, Haribiyu extract, Aozuzuran extract, Amaranthus hippochondriax extract, Aristolomeria (Yurizuisen) extract, Alcana (alcanna) extract, Argarobo (cabbage) extract, Aloe vera extract, Rabbit extract (Yellow grass) extract, Yew (first place) extract, Strawberry extract, Carob extract, Inazuna (Tailexi) extract, rice extract, dog mint extract, sardine tobacco (Iwatsuki) extract, sardine hiba extract, sardine pine (roll mushroom) extract, wheat (chibusanoki) extract, duckweed (float) extract, euglena extract Uncaria extract, Enokitake mushroom extract, Eringi extract, Pre-lotus eringi extract, Ogata Hakken extract, Oguruma (civil engineering incense) extract, Oohushigusa (cereal essence) extract, Okaeki , Okazeri (snake bed) extract, Okra extract, Onidokoro extract, Tokoro extract, Nagadokoro (hikai) extract, Ononis extract, Yuuko extract, Oyster extract, Ginseng extract, Gaku hydrangea extract, Cascara sagrada extract, Gypsophila extract , Panax ginseng extract, canniwa extract, carnation extract, gerbera extract, camcam (camo duck) extract, color extract, oat extract, oak radish (compulsed greens), kawajisha extract, kawaranadeshiko (stone bamboo) extract, Ezokawara nadeshiko (soba, Buckwheat extract, Kantarasa extract, Kikutaniku extract, quinoa extract, cabbage extract, kiwi extract, cucumber extract, gyory (Nishikawa willow, dairyagi) extract, Kiranso Golden peony grass extract, guayule extract, squirrel katsura (Tenmon winter) extract, kuzu (kudzu) extract, kuonjinjin (yellow flower bud) extract, cupuasu extract, ganbainazuna (sekimei, sekimeishi) extract, kenponashi (kigushi) extract, gekkavidin (month) Shimoda) extract, Kouren (Huo Ren) extract, coconut extract, cosmos extract, coconut krill extract, rice oil extract, konjac extract, saffron (bancho flower, west safflower) extract, sapodilla extract, sangre degrad (croton) extract, sun Cytin carrot (37 ginseng) extract, shea (carite) extract, cyanoki extract, shiitake extract (shiitake) extract, shimeji mushroom extract, hinoki shimeji mushroom extract, shaka shimeji mushroom extract, hatake shimeji mushroom extract, oshiroi shimeji mushroom extract, beech shimeji mushroom extract, honji mushi extract , Shirotamogitake extract, Shimokurene extract, Saishin extract, Cactus extract, Janohige (Bakumon winter) extract, Shukukonkamiso extract, Zhao hydrangea extract (Tsunyama) extract, Shirocho butterfly extract, White-leafed adzuki bean (chicken bone grass) extract , Jinchoge (Mizuka, Mika, Shencho) extracts, Watermelon (Saijo) extract, Suzu-Psycho (Xucho) extract, Surihiyu (Horse-tooth soap, Horse-tooth soap) Extract, Sekkoku extract, Sakura Sekkoku extract, Koki Sekkoku extract, Obanasekkokoku Extract, Okinawan extract, Honkokukoku extract, Butterberry extract, Deer extract, Kibananokekku extract, Cedron extract, Zenia oyster extract, Celery extract, Senshinren extract, Daikon (Large) ) Extract, Takasaburo extract, Tachidokoro (hikai) extract, dahlia (tenjiku button) extract, Talwei extract, papaver extract, cassava extract, Chankapiedra extract, tulip extract, chorogi extract, tsukuritake ( Mushroom extract, camellia extract, clover (lacquered licorice) extract, tonabena (river cut) extract, corn extract, corn hair (southern cocoon) extract, toxa (wood bandits) extract, ash (crustacean) extract, turkish leopard extract, jujube Extract, vertical blade (sword bean) extract, jujube (large cocoon) extract, navena (continuous) extract, sea cucumber extract, namban karamashi (reed hemp) extract, iois violet extract, nutmeg extract, nem extract, neb extract, nebi extract, ne Linoki extract, Digokubana (community) extract, Nogateto extract, Hylindough extract, Hauchiwa extract, Hauchi bean extract, Papaya extract, Pahalobobo extract, Balata rubber tree extract, Agaric extract, White-faced agaric extract, Ukimorinoka extract, Haran extract, Pariurus Balsamina (Villus serrata, bitter gourd) extract, Harlin Dou extract, Handaikai (胖大海) extract, Hygurmadori extract, Beet extract, Hiba extract, Sunflower extract, Pepper extract, Himezu (Tenpo) extract, Japanese apricot (Kariharatake, Hiromatsutake) extract, Euphorbiaceae extract, Brazilian daylily extract, hazelnut extract, loofah extract, crassulaceae extract, nettle (jingten) ) Extract, scallop extract, sardine extract, nendo extract, scallop extract, ground scallop extract, spinach (acupuncture, acute pupa, zona pellucida) extract, falcon extract, joseph ginseng extract, jojoba extract , Borage (Rurichisha) extract, Bordeaux extract, Hononiku (meat juju, Taigei) extract, Honsekkok (iron skin stone, sparrow mountain stone) extract, Maca extract, Macadamia nut extract, Margaret (Mokushungiku) extract, Tamanozen Hallen extract , Cucumber nasturtium extract, matatabi extract, matsukasa extract, matsuhodo (bamboo shoot) extract, matico (cordon sillo) extract, quince extract, malein (broad mulberry squid) extract, manzanya (andesca mitsule) extract, mizusobako Kiss, Japanese morning glory extract, Green mint extract, Wheat strawberries extract, Munya extract, Murasakikikibu extract, Omurasakikibu extract , Cornflower extract, yacon extract, palm extract, yabu tobacco (crane candy, Tennasei) extract, maronier extract, mokka extract, lily extract, raigan (Raimaru) extract, lime extract, rye extract, rakkyo extract, shallot (white) extract, Apple extract, gentian extract, litchi (wicker, toothpick nucleus) extract, Astragalus extract, Yokuinin extract, mini Sasanishiki extract, Chlorella vulgaris extract, Chlorella pyrenoid extract, Chlorella ellipsoidia extract, Crostis pirifera extract, Yuikiri extract, Tosakanori extract, Cyprinus extract, Amakusanori extract, Aoimidro extract, Kawanori extract, Marimo extract, Motsukihitoe extract, Ezoyahaz extract, Habanori extract, Habanori extract, Watamo extract, Aname extract, Sujime extract Extract, Vineyard extract, Blackcurrant extract, Necoa lucidum extract, Ainu Wakame extract, Chigaiso extract, Ezoi Shige extract, Yabanemoku extract, Trumpet extract, Uganomok extract, Jolomok extract, Hiemok extract, Tamanashimoku extract, Honda walnut extract, Sugi mok extract Extract, Akebono mozuku extract, Cyprinus extract, Fusanori extract Minohana extract, Hanafnori extract, Itofonori extract, Kaginori extract, Mirin extract, Hosobamyrin extract, Kikutosaka extract, Ezonameshi extract, Ibaranori extract, Kagyi baranori extract, Saidaibara extract, Tahibara extract, Ogonori extract, Tsurushiramo extract, Bee cricket Examples of the extract include Japanese beetle extract, Japanese cypress extract, red ginseng extract, cultured natto metabolite, natto extract, loofah water, birch (white birch) or red pine sap.

Cell activating agent / metabolic activator A cell activating agent / metabolic activator can be added to the present invention. Specific examples of cell activators and metabolic activators include vitamin A group: retinol or its salts and derivatives thereof (retinyl unsaturated fatty acid esters such as retinyl linoleate, retinyl linolenate, retinyl oleate, retinyl arachidonic acid, etc.) ), Retinal or a salt thereof and derivatives thereof, dehydroretinal or a salt thereof and derivatives thereof, retinoic acid or a salt thereof and derivatives thereof, retinoic acid analogs (4-[[[8- (3,5-dimethylphenyl ) -2-Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3-methylphenyl) -2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[[8- (4-methylphenyl) ) -2-Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3,4- Dimethylfe Nyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2,4-dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2 -Isopropylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-ethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2 -Fluorophenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methoxyphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(8-benzyl- 2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[(E) -2- (8-phenyl-2-naphthalenyl) propenyl] benzoic acid), retinoic acid derivative (4-hydroxyphenylretinamide), retinoid analogues (4-[[(5,6-dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[(5, 6-dihydro-5,5,8-trimethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) amino] Carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5, 5,8-Trimethyl-2-naphthalenyl) -carbonyl] amino] benzoic acid, 4- (E)-[2- (5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) -1 -Propenyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) oxy] carbonyl] benzoic acid, 4-[[(5,6-dihydro-5 , 5-Dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl) oxy ] Benzoic acid, 4-[[5,6-dihydro-5,5-dimethyl-8- (2-fluoro Enyl) -naphthalenyl] carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5,6-trimethyl) -8-phenyl-2- (naphthalenyl) carbonyl] amino] benzoic acid, 4- [[(5,6-dihydro-5,5,7-trimethyl-8-phenyl-2-naphthalenyl) carbonyl] benzoic acid, 4-[[((E)-(5,6-dihydro-5,5-dimethyl -8-phenyl) -2-naphthalenyl] vinyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] sulfamyl] benzoic acid, 4 -[[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] sulfamyl] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8 -Phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] thiocarbonyl] amino] benzoic acid, 4- [[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalene Ru] carbonyl] methyl] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] oxy] benzoic acid, 4-[[[((5 , 6-Dihydro-5,5-dimethyl-8-phenyl) -2-naphthenyl] oxy] methyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8- (2, 4-Dimethylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8- (4-methylphenyl)]-2-naphthalenyl] Carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4-[[[(5,6-dihydro- 5,5-dimethyl-8-phenyl) -2-naphthalenyl] sulfamyl] methyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] Amino] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] amino] thioca Bonyl] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] sulfamyl] benzoic acid, 4-[[[(5,6-dihydro -5,5-dimethyl-8-phenyl-2-naphthalenyl] amino] methyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl ] Amino] -2-hydroxybenzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-nitrobenzoic acid, 4- [[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-fluorobenzoic acid, 4-[[[((5,6-dihydro-5, 5-Dimethyl-8-phenyl-2-naphthalenyl] carbonyl] amino] -2-methoxybenzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8- (2-naphthalene)]- 2-Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-8-phenyl-2-naphthalenyl) ) Carbonyl] aminobenzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) carbonyl] amino] -3-fluorobenzoic acid, 4-[[((5, 6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) carbonyl] amino] -3-methylbenzoic acid, 4-[[(5,8,10,10a-tetrahydro-10,10-dimethyl- 9-phenyl-2-anthracenyl) carbonyl] amino] benzoic acid, 4-[[((1,1-dimethyl-3-phenyl-1H1-inden-5-yl) amino] carbonyl] benzoic acid, 4-[(1 , 1-Dimethyl-3-phenyl-1H-inden-5-yl-oxymethyl) benzoic acid, 4- [2- (1,1-dimethyl-3-phenyl-1H-inden-5-yl) vinyl] benzoic acid Acid, 4-[(1,1-dimethyl-3-phenyl-1H-indene-5-carbonyl) amino] benzoic acid), carotene or a salt thereof and derivatives thereof (α-carotene, β-carotene, γ-carotene, lycopene, Cryptoxanthi , Lutein, zeaxanthin, isozeaxanthin, rhodoxanthine, capsanthin, crocetin and other carotenoids), lycopene or salts thereof and derivatives thereof, vitamin B group: thiamine or salts thereof and derivatives thereof (thiamine hydrochloride, thiamine disulfide, bisbench Amines, bis-butyamines, thiamine monophosphate disulfides, benfotiamines, chicotiamines, octothiamines, dicetiamines, fursultiamines, prosultiamines, astaxanthinthiamine phosphate diesters), thiamine sulfates, riboflavins or their salts and their Derivatives (flavin adenine dinucleotide, flavin mononucleotide, riboflavin phosphate diester, 1-β-D-ribofuranosylnicotinamide pyrophosphate diester, 1-β-D- Bofuranosylnicotinic acid, etc.), pyridoxine or a salt thereof and derivatives thereof (pyridoxine 3,4-dipalmitate, pyridoxine 3,4-dicaprylate, pyridoxine sulfate diester, etc.), pyridoxal or a salt thereof and derivatives thereof, pyridoxamine Or salts thereof and derivatives thereof, cyanocobalamin or salts thereof and derivatives thereof, cobalamines (methylcobalamin, adenosylcobalamin, hydroxocobalamin, aquacobalamin etc.), folic acid or salts thereof and derivatives thereof, nicotinic acid or salts thereof and Derivatives thereof, pantothenic acid or a salt thereof and derivatives thereof, biotin or a salt thereof and derivatives thereof, choline or a salt thereof and derivatives thereof, inositol or a salt thereof and derivatives thereof, vitamin C group: ascor Binic acid or its salts and derivatives thereof, vitamin D group: Ergocalciferol or its salts and their derivatives, cholecalciferol and its salts and their derivatives (1α-hydroxy-22-[(1-hydroxy-1- Methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1R, 4R] -1α-hydroxy-22-[(1-hydroxy-1- Methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1R, 4S] -1α-hydroxy-22-[(1-hydroxy-1- Methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorcorecalciferol, [1S, 4R] -1α-hydroxy-22-[(1-hydroxy-1- Methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorcorecalciferol, [1S, 4S] -1α-hydroxy-22-[(1-hydroxy-1- Methyl) -2-si Clopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, etc.), dihydrotaxosterol or a salt thereof and derivatives thereof, vitamin E group: tocopherol or a salt thereof and derivatives thereof , Tocotrienol or a salt thereof and derivatives thereof, ubiquinone or a salt thereof and derivatives thereof, vitamin K group: phytonadione or a salt thereof and derivatives thereof, menaquinone or a salt thereof and derivatives thereof, menadione or a salt thereof and derivatives thereof, Menadiol or a salt thereof and derivatives thereof, vitamin F group: linoleic acid or a salt thereof and derivatives thereof, linolenic acid or a salt thereof and derivatives thereof, carnitine or a salt thereof, and the like Derivatives, ferulic acid or salts thereof And derivatives thereof, γ-oryzanol or salts thereof and derivatives thereof, orotic acid or salts thereof and derivatives thereof, vitamin P group: rutin or salts thereof and derivatives thereof, eriocitrin or salts thereof and derivatives thereof, hesperidin Or salts thereof and derivatives thereof, vitamin L group: anthranilic acid or salt thereof and derivatives thereof, adenylthiomethylpentose or salt thereof and derivatives thereof, vitamin U group: methylmethionine sulfonium chloride or derivative thereof, valine, leucine , Isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glu Minic acid, hydroxylysine, arginine, ornithine, histidine or derivatives thereof (N-octyloxycarbonyl-β-alanyl-L-histidine, N-dodecyloxycarbonyl-β-alanyl-L-histidine, N- (12-amino- 1-oxododecyl) -L-histidine, N-2-ethylhexyloxycarbonyl-β-alanyl-L-histidine hydrochloride, N-hexadecyloxycarbonyl-β-alanyl-L-histidine, N-octylaminocarbonyl-β -Alanyl-L-histidine, N-dodecylaminocarbonyl-β-alanyl-L-histidine, N-dodecylsulfonyl-β-alanyl-L-histidine, N-dodecylamino-oxalyl-β-alanyl-L-histidine, etc.) Amino acids such as sulfates, phosphates, nitrates, citrates or amino acid derivatives such as pyrrolidone carboxylic acid, glycolic acid, Α-hydroxy acids such as acid, malic acid, tartaric acid, lactic acid, succinic acid, 2-hydroxycarboxylic acids (methyl lactic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid, 2-hydroxyheptane Acid, 2-hydroxyoctanoic acid, 2-hydroxynonanoic acid, 2-hydroxydecanoic acid, 2-hydroxyundecanoic acid, α-hydroxylauric acid, α-hydroxymyristic acid, α-hydroxypalmitic acid, α-hydroxystearic acid, α-Hydroxyarachidonic acid, cerebronic acid, α-hydroxynervonic acid, mandelic acid, benzylic acid, phenyllactic acid, atrolactic acid, 2- (4'-hydroxyphenyl) -2-hydroxyethanoic acid, 2- (4'-chlorophenyl) ) -2-Hydroxyethanoic acid, 2- (3'-hydroxy-4'-methoxyphenyl) -2-hydroxyethanoic acid, 2- (4'-hydroxy-3'-me Xylphenyl) -2-hydroxyethanoic acid, 3- (2'-hydroxyphenyl) -2-hydroxypropanoic acid, 3- (4'-hydroxyphenyl) -2-hydroxypropanoic acid, 2- (3 ', 4'- Dihydroxyphenyl) -2-hydroxyethanoic acid, glyceric acid, erythronic acid, ribbon acid, arabinonic acid, xylonic acid, lyxonic acid, arolic acid, altronic acid, gluconic acid, mannonic acid, gulonic acid, idonic acid, galactonic acid, talon Acid, glucoheptonic acid, galactoheptonic acid, tartronic acid, mucinic acid, etc.), polyhydroxycarboxylic acid or hydroxypolycarboxylic acid (gluconolactone, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, sugar lactone) , Pantoyl lactone, glucoheptonolactone, mannonolactone, Lactofeptonolactone, etc.), 2-keto acids (glyoxylic acid, methyl 2-ketoethanoate, benzoylformic acid, methyl benzoylformate, ethyl benzoylformate, phenylpyruvic acid, methyl phenylpyruvate, ethyl phenylpyruvate, 2-ketobutanoic acid 2-ketopentanoic acid, 2-ketohexanoic acid, 2-ketoheptanoic acid, 2-ketooctanoic acid, 2-ketododecanoic acid, methyl 2-ketooctanoate), quinic acid, isocitric acid, tropic acid, tretocanic acid, 3-chlorolactic acid , Cerebronic acid, citramalic acid, agaricinic acid, aleuricinic acid, pantoic acid, lactobionic acid, hexrosonic acid, photosensitizer 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, pentadecanoic acid glyceride, linolenic acid or derivatives thereof, eicosapentaenoic acid Or a derivative thereof, Sahexaenoic acid or its derivatives, estradiol, etenyl estradiol, antialol or its glycoside, lionilesinol or its glycoside, rhododendrol or its glycoside, platyphyronol or its glycoside, lactone compound (D- Glucurono-6,3-lactone, α-D-glucoheptonic-γ-lactone, δ-glucuronolactone, α, β-glucooctonic-γ-lactone, L-glonic-γ-lactone, γ-D- Galactonolactone, D-saccharide-1,4-lactone, D-saccharide-3,6-lactone, D-ribonic-γ-lactone, α-butyrolactone, γ-butyrolactone, α-octanoic lactone, γ-octa Neutic lactone, Nonanoic lactone, γ-valerolactone, D-manninoic-δ-lactone, D-xyleuic-δ-lactone, D-arabinoic-δ-lac , Stearoyl-δ-gluconolactone, DL-pantolactone, palmitoyl-DL-pantolactone, etc.), 3-hydroxy-3,4-dicarboxy-1,4-butanolide or its derivatives, 6-benzylaminopurine or Its derivatives, 1,4-diazadicyclooctane, 2,5-dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran, rutin, tectrigenin 7-xylosylglucoside, captopril , Alasepril, lisinopril, enalapril, delapril, benazepril, cilazapril, imidapril, quinapril, trandelapril, perindopril, temocapril, losartan, endothelin, galactomannan saccharide polymer, mucin, trimethylglycine, proteoglycan, lactic acid bacteria extract, lactic acid bacteria extract, lactic acid bacteria extract, lactic acid bacteria extract fermentation Milk extract, bifidobacteria extract, bifidobacteria culture solution extract, bifidobacteria fermented milk extract, placenta extract, ganoderma extract, spleen extract, thymus extract, yeast extract, yeast culture extract, yeast fermentation extract, filamentous fungus extract, filamentous fungus Culture fluid extract, basidiomycete extract, basidiomycete culture fluid extract, bacterial cell disruption extract, bacterial culture fluid extract, cultured human dermal cell disruption extract, red ginger (ground yellow) extract, fennel (cage) extract, Ezokogi ) Extract, barley (barley) extract, oakuri higotai (Zhengzhou leakage) extract, scabbard hypericum extract, Hypericum perforatum extract, Dutch jellied extract, Dutch honeybee extract, silkworm extract, Roman chamomile extract, garcinia extract, kawaran ginseng ( Blue agate) extract, oyster extract Quillaja extract, quince extract, ginkgo biloba extract, calendula extract, sakaneran (Ezosa kaneran) extract, Sababagin orchid extract, Sawagurumi (Yamatomo) extract, shimotake extract, shajin extract, plum extract, cedar extract, cedar extract, pineapple extract, Chinese cabbage extract, Japanese cypress (shooting) extract, beech extract, physalis (Torone) extract, maitake (maiko) extract, misohagi (chinese cucumber) extract, mugwort (kiso) extract, mukuroji (prolonged skin) extract, bean sprout extract, Eucalyptus extract, Yukinoshita (tiger ear grass) extract, Suabisimus (cool) extract, lettuce (Chisha) extract, aloe extract, Ogon extract, Tonka bean extract, Gentianana extract, Burdock extract, Shikon extract, carrot extract Clam essence extract, hop extract, Yokuinin extract, Odori extract, assembly extract, toki extract, eucalyptus extract, Achacha extract, hypericum extract, cucumber extract, gypsophila extract, rosemary extract, parsley extract, Sanadagusa extract, fukurimamiji extract , Rattle comb extract, oyster comb extract, oni kombu extract, gohei comb extract, naga kombu extract, pea kumbu extract, large dwarf extract, rattle extract, rattle extract, beni mozuku extract, hoso beni mozuku extract, kagekinori extract, Examples include ezotosaka extract, silamo extract, birch extract and the like.

Antioxidant An antioxidant can be added to the present invention. Specific examples of antioxidants include ascorbic acid or a salt thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl hydroxyprophosphate, 5-o-α -D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid Sulfate ester Nium salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyranosyl -L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl-L -Ascorbic acid, 6-o-alkylascorbic acid phosphate potassium salt, 6-o-alkylascorbic acid phosphate cal Um salt, 6-o-alkyl ascorbic acid phosphate barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o-alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl ascorbine Acid phosphate ester diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine Salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate Cholesterol ester, palmitate L-ascorbyl, isopalmitate L- Scorbyl, L-ascorbyl dipalmitate, L-ascorbyl diisopalmitate, L-ascorbyl stearate, L-ascorbyl isostearate, L-ascorbyl distearate, L-ascorbyl diisostearate, L-ascorbyl myristate, isomyristate L-ascorbyl, dimyristic acid L-ascorbyl, diisomyristic acid L-ascorbyl, 2-ethylhexanoic acid L-ascorbyl, di-2-ethylhexanoic acid L-ascorbyl, oleic acid L-ascorbic acid, 2-o-α -D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D- Glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitin Acid ester, L-ascorbic acid tetralauric acid ester, L-ascorbic acid tetra-2-ethylhexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, L-ascorbic acid Retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L- Ascorbyl triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl] -4 '-Acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid diester, ascorbic acid ino Toll-binding derivatives, ascorbic acid phosphoramide derivatives, ascorbic acid arbutin conjugates, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivatives, ascorbic acid sialic acid derivatives, etc.), stearates, tocopherols or salts thereof and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate, tocopherol succinate, Tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocophere Lyl glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α- Tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ -Tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L- γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- (sulfoethylamino) -3- (α-tocopheryl-6 -Iroxy) propan-2-ol, 1- (carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl ] Cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy)- 2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol) , Γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate), di Dropyridine derivatives (methyl-3-phenyl-2-propenyl 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) pyridine-3,5-dicarboxylate and its salts), benzochroman derivatives, nor Dihydroguaselectenic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, coenzyme Qn (n = 7-10), pyrroloquinoline quinone, propyl gallate, sesamol, sesamorin, Gossypol, maritimane, sulfretin, xanthene-2,7-diols, caffeoylquinic acids, propolis, carotenoids (α-carotene, β-carotene, γ-carotene, lycopene, lutein, violaxanthin, spiroloxanthine, spheroidene, Astaxanthin), fluorotannin, akebi (wood) ) Extract, Achacha (Amacha) extract, Oolongcha extract, Dutch biloba extract, kanran extract, kumquat extract, gobishi extract, geno shochu (old lady's grass) extract, sesame extract, sesame culture cell extract, sesame extract, rice bran extract, pomegranate extract , Salamander extract, Pear extract, Daio extract, Tomato extract, Nanten extract, Noahami extract, Neubara extract, Paprika extract, Pistachio extract, Biwa extract, Betel wax (Large garment, coconut) extract, Japanese cypress extract, bokeh (wooden) extract, Hosoba-Oguruma extract, Mao (mao) extract, mimosa extract, Japanese cypress extract, Japanese black willow extract, willow deer extract, cotton-fat deer Kurami Domonas extract, red snow extract, red clover extract, red clover extract, hypericum extract, clam extract, clove extract, melissa extract, enamel extract, birch extract, salvia extract, rosemary extract, southern berry extract, ginkgo biloba extract, green tea extract, Examples include clove extract.

Active oxygen scavenger / radical scavenger An active oxygen scavenger / radical scavenger can be added to the present invention. Specific examples of active oxygen scavengers and radical scavengers include superoxide dismutase, catalase, glutathione peroxidase, bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or derivatives thereof, gallic acid or salts thereof, and derivatives thereof, curcumin Or salts thereof and derivatives thereof, transferrin, ceruloplasmin, coenzyme Qn (n = 7 to 10), uric acid, bilirubin, metallothionein, stilbengaloyl glycoside (3,5,4′-trihydroxystilbene 4′-o -β-D- (6 "galloyl) glucopyranoside, 3,5,4'-trihydroxystilbene 4'-o-β-D- (2" galloyl) glucopyranoside, etc.), chlorogenic acid phospholipid ester, chlorogenic acid sphingosine ester And derivatives thereof, chlorogenic acid glycolipid ester, black Rogenic acid sugar ester, chlorogenic acid sterol ester, thiazole derivative or salt thereof (2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxyphenyl) thiazole, 2- (3,4-di Ethoxyphenyl) -4- [3-carboxy-4-hydroxy-5- (2-methyl-2-propenyl) phenyl] thiazole and 2- (3,4-diethoxyphenyl) -4- (3-carboxy-4 -Hydroxy-5-methylphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- (3-carboxy-5-methoxyphenyl) thiazole), hydroxymatylesinol, allohydroxymatylesinol, hydantoin derivatives , Akaminoki (logwood) extract, Akamegashiwa (red buds) extract, Akamino Akane extract, Acacia akane extract, Akane (Hakusai) extract, Hydrangea (hydrangea) extract, Abemaki extract, Chijiku extract, Ginkgo biloba extract, Asparagus extract, Japanese apricot extract, Vulcania serrata extract, Japanese walnut extract, Estragon extract, Enju (Safflower, Satsuma rice) extract, Kashiwa (Shinoki, Kashiwa) extract , Genus extract, birch extract, birch extract, cucumber extract Extract, Sasa (butterfly) extract, Perilla extract, Ajizo extract, Chimmento extract, Katamen diso extract, Peonies extract, Quercus extract, Mizunara extract, Crape myrtle extract, Zicopi extract, Shirakashi extract, White clover Clover) extract, horseradish extract, black tea extract, green tea extract, camellia extract, tencha (boiled tea) extract, tendaiu yak extract, nani waibara (gold cherry) extract, peanut (peanut) extract, kei extract, nikkei extract, ceylon nikkei extract, yavnikkei ( Cinnamon (bark) extract, cinnamon (Keishi branch) extract, nozenkazura (Ryoen flower) extract, lotus (extract), Chinese cabbage extract, hadakamugi extract, hanasuge (my mother) extract, hermanus (maikai flower) extract, rose (rose) extract, barbus Co-extract, Spinach extract, Beech extract, American beech extract, Inu beech extract, European beech extract, Convolvulus extract, Hosobaokera (蒼朮) extract, Button (peony) extract, Mayoram (Butterfly) extract, Melon extract, Examples include evening primrose extract, snow willow extract, orchid extract, rakanka extract, rooibos extract, naminohana extract, eucalyptus extract, scallop extract, azusa extract, basil extract, mokko (wood fragrance) extract, himefuuro extract, lemongrass extract and the like.

Fat Metabolism Promoter A fat metabolism promoter can be added to the present invention. Specific examples of fat metabolism promoters include phthalazine derivatives (4-ethyl-1- (β-hydroxyethylamino) phthalazine, 4-N-propyl-1- (β-hydroxyethylamino) phthalazine, 4-N-butyl- 1- (β-hydroxyethylamino) phthalazine, 4-N-butyl-1- (β-hydroxypropylamino) phthalazine, etc.), xanthine derivatives (caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, diprofylline, proxy) Phyllin, oxtriphilin, etc.), Aotsuki-rafuji (wooden candy) extract, thistle extract, aletia thistle extract, mite thistle extract, scrub thistle extract, noel thistle extract, blue thistle extract, cacao extract, elcampuri extract, otsu-rafuji (preventive self) Extract, banquet extract, Karaku salmon man Kiss, Kyoukyo (Kikkyo, Kikyo Root) Extract, Ivy Extract, Pepper (Pepper) Extract, Cola Acuminata Extract, Sagiomodaka (Sawamata) Extract, Pomelo Extract, Sanshuyu (Yamatake) Extract, Tsutsu Rafu Extract, Otsu Samurai Extract, Chorei Maitake (猪苓) Extracts, Cranella extract, Proboscis extract, Ginseng extract, Korean ginseng extract (Ryu gall) extract, Naginata kouju extract, Banana extract, Puer tea (common ear tea) extract, Plum extract, Buufu (windproof) extract, etc. It is done.

UV protection agent / UV absorption promoter An UV protection agent / UV absorption promoter can be added to the present invention. Specific examples of UV protective agents and UV absorption accelerators include benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5- Sodium sulfonate, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), 1,2-dihydroxy-4- (2-hydroxyethyl) benzene derivatives (1- (2- (4- (3,4-Dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) -3- Rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (2-acetyl-4- (3,4-dihydride) Xycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (2-acetyl-6- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3, 4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (6- (4-hydroxy -3-methoxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1- Methoxyethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-hydroxyethyl-3,4-dihydroxybenzene, 1- ( 2- (6- (3,4-Dihydroxycinnamoyl) -3-xylosyl) glucosyl) eth Ru-3,4-dihydroxybenzene, 1- (2- (3-allosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- ( 3-glucosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (3-arosyl-6- (3-hydroxy-4-) Methoxycinnamoyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2 -(3- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (2- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4 -Dihydroxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydride Xylbenzene, etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc.), methoxycinnamate derivatives (ethyl paramethoxycinnamate, paramethoxy, etc.) Isopropyl cinnamate, octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, glyceryl di-2-methoxycinnamate mono-2-ethylhexanoate), anthranilic acid derivatives (such as methyl anthranilate) , Urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimi Derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, pyridoxine derivatives, pyridoxal derivatives, pyridoxamine derivatives, amethoflavone, neosacranine, 6-dehydrocaine, triazine derivatives (4,4 '4 "-(1,3,5-triazine-2,4,6-triyltriimino) trisbenzoic acid tris-2-ethylhexyl etc.), phosphatidyl chromanol derivatives (1,2-dilaurolylglycero-3- Phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-dimyristoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6'-hydroxychroman, 1,2-dipalmitoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl -6'-hydroxychroman, 1,2- Stearoyl glycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-dialachidonylglycero-3-phospho-2'- Hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-myristoyl-2-palmitoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7 ', 8'-Tetramethyl-6'-hydroxychroman, 1-myristoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6 ' -Hydroxychroman, 1-palmitoyl-2-myristoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-palmitoyl-2- Stearoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-stearoyl-2-myristoylglycero-3-phospho-2'- Hydroxyme 2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-stearoyl-2-palmitoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7' , 8'-tetramethyl-6'-hydroxychroman, etc.), L-carnosine zinc complex, umbelliferone, esculin, benzyl cinnamate, cinoxalate, oxybenzone, dioxybenzone, octabenzone, soribenzone, benzoresorcinol, arbutin, guaiazulene, Shikonin, baicalin, baicalein, berberine, neoheliopan, chlorophylls, xanthophylls, escalol, zinc oxide, talc, kaolin, anthracite extract, hub extract, giant rush extract, cassava extract, kawatake extract, islet jellyfish extract , Hassai extract, Spirulina extract , Aiacacio extract, Funori no Ushike extract, Himetengususa extract, Hytengususa extract, Oobusa extract, Chinomori extract and the like.

Astringents Astringents can be added to the present invention. Specific examples of astringents include succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannins (tannic acid, hammelitannin Acer tannin, tetragalloyl glucose, pentagalloyl glucose, hexagalloyl glucose, heptagalloyl glucose, octagalloyl glucose, nonagaroyl glucose, decagalloyl glucose, undecagalloyl glucose, dodecagalloyl glucose, etc. Gallotannins, telimaglandin I, telimaglandin II, casarictin, peduncraggin, geraniin, isoturkevin, granatin A, granatin B, ketulinic acid, keblagic acid, casuarinin, nuphalin, procyanidin B-2 Ellagitannins such as thiacinensin A and thiacinensin B), red grape grape extract, azuki bean (red bean) extract, altea extract, nettle extract, cascarilla extract, kapoch extract, guarana extract, ezo strawberry extract, Dutch strawberry extract, shrimp strawberry extract , Japanese White Strawberry Extract, Maple Strawberry Extract, European Raspberry Extract, Kidachi Aloe Extract, Hawthorn Extract, Coustella Hakka Extract, Cowberry (Etsutachibana) Extract, Cola Vera Extract, Sugarcane Extract, Chinese Red Flower Extract, Honeysuckle Extract Q) Extract, Japanese larch extract, Elder extract, Dandelion extract, Centarium extract, Shirobana dandelion extract, Mouko dandelion extract, Tsurua Woodpecker extract, Tsurutsuchiakebi extract, Teuchigurumi extract, Tormentilla extract, Novara extract, Tokiwyo Ryu extract, Hagoromogusa extract, Castor extract, Grape extract, Prune extract, Veronica extract, Bisnaga extract, Bilberry extract, Mansugulumi extract, Mitsuga wrinkle extract, Myrrh extract, Examples include melissa extract, witch hazel extract, black willow extract, latania (chlamelia) extract, and corn poppy extract.

Anti-inflammatory agent, interleukin production inhibitor, histamine release inhibitor An anti-inflammatory agent, interleukin production inhibitor, histamine release inhibitor can be added to the present invention. Specific examples of anti-inflammatory agents, interleukin production inhibitors and histamine release inhibitors include quinolinone derivatives, dibenzooxepin derivatives, thiotroposin, phthalimide derivatives, flurbiprofen, felbinac, bufexamac, suprofen, 1,4-diphenylpropyl Piperazine derivatives, carxin compounds, chromanol glycosides (2- (α-D-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol), ictamol, indomethacin, kaolin, diphenhydramine hydrochloride, d- Camphor, DL-camphor, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, diphenhydramine hydrochloride, clemastine fumarate, cyproheptadine hydrochloride, Promethazine hydrochloride, piperazine derivatives, α-D-phenylglycoside derivatives, glycyrrhizic acid or salts thereof and derivatives thereof (α-glycyrrhizic acid, β-glycyrrhizic acid, α-glycyrrhizic acid methyl ester, β-glycyrrhizic acid methyl ester, α- Trisodium glycyrrhizinate, monopotassium α-glycyrrhizinate, dipotassium α-glycyrrhizinate, monoammonium α-glycyrrhizinate, trisodium β-glycyrrhizinate, monopotassium β-glycyrrhizinate, dipotassium β-glycyrrhizinate, β-glycyrrhizic acid mono Ammonium), glycyrrhetinic acid or a salt thereof and derivatives thereof (α-glycyrrhetinic acid, β-glycyrrhetinic acid, stearyl α-glycyrrhetinic acid, stearyl β-glycyrrhetinic acid, pyridoxyl α-glycyrrhetinic acid , Β-glycyrrhetinic acid pyridoxine, α-glycyrrhetinic acid glycerin, β-glycyrrhetinic acid glycerin, 3-succinyloxyglycyrrhetinic acid disodium, etc.), mefenamic acid, phenylbutazone, ibuprofen, ketoprofen, allantoin, calcium pantothenate, pantothenylethyl Panthenol such as ether or salts thereof and derivatives thereof, ε-aminocaproic acid, diclofenac sodium, tranexamic acid or derivatives thereof (trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-nitrobenzyloxycarbonyl Aminomethylcyclohexanecarboxylic acid, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-bromobenzyloxycarbo Ruaminomethylcyclohexanecarboxylic acid, trans-4-m-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methylbenzyloxycarbonylamino Methylcyclohexanecarboxylic acid, sodium trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylate, ammonium trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid Potassium acid, potassium trans-4-p-bromobenzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-m-chlorobenzyloxycarbo Calcium nylaminomethylcyclohexanecarboxylate, magnesium trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexanecarboxylic acid monoethanolamine, trans-4-t- Butyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- ( 3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) Cyclohexanecarboxylic acid, sodium trans-4-t-butyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylate, trans-4- (p-biphenylisopropyloxycarbonyl) Aminomethyl) calcium cyclohexanecarboxylate, trans-4- (3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) magnesium cyclohexanecarboxylate, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid monoethanolo- Lumine, trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4-methylsulfonylethyloxycarbo Ruaminomethylcyclohexanecarboxylic acid, trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) sodium cyclohexanecarboxylate, potassium trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4- (pyridine -4'-methyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexane Potassium carboxylate, trans-4- (pyridine-4′-methyloxycarbonylaminomethyl) cyclohexanecarboxylate sodium, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexane Potassium sancarboxylate, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylate, etc.), tranexamic acid amide or a salt thereof, and derivatives thereof (trans-4-aminomethylcyclohexanecarbonamide, trans-4 hydrochloride) Aminomethylcyclohexanecarbonamide, Nn-hexyl-trans-4-aminomethylcyclohexanecarbonamide, Nn-hexyl-trans-4-aminomethylcyclohexanecarbonamide hydrochloride, Nn-heptyl-trans-4- Aminomethylcyclohexanecarbonamide, Nn-heptyl-trans-4-aminomethylcyclohexanecarbonamide hydrochloride, Nn-butyl-trans-4-aminomethylcyclohexanecarbonamide N-butyl-trans-4-aminomethylcyclohexanecarbonamide, Nn-propyl-trans-4-aminomethylcyclohexanecarbonamide, N-cyclohexyl-trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N -Cyclohexyl-trans-4-aminomethylcyclohexanecarbonamide, N, N-dicyclohexyl-trans-4-aminomethylcyclohexanecarbonamide, N, N-dicyclohexyl-trans-4-aminomethylcyclohexanecarbonamide hydrochloride, N, N- Diethyl-trans-4-aminomethylcyclohexanecarbonamide, N, N-diethyl-trans-4-aminomethylcyclohexanecarbonamide hydrochloride, N-benzyl-trans-4-aminomethyl Cyclohexanecarbonamide, N-benzyl-trans-4-aminomethylcyclohexanecarbonamide hydrochloride, N- (4'-methoxyphenyl) -trans-4-aminomethylcyclohexanecarbonamide, N- (4'-methoxyphenyl) hydrochloride -Trans-4-aminomethylcyclohexanecarbonamide, N- (4'-ethoxyphenyl) -trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N- (4'-ethoxyphenyl) -trans-4-aminomethylcyclohexanecarboxylic acid Amide, N- (2'-methylphenyl) -trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N- (2'-methylphenyl) -trans-4-aminomethylcyclohexanecarbonamide, N- (3'-methylpheny ) -Trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N- (3'-methylphenyl) -trans-4-aminomethylcyclohexanecarbonamide, N- (4'-chlorophenyl) -trans-4-aminomethylcyclohexanecarboxylic acid Amide, hydrochloric acid N- (4′-chlorophenyl) -trans-4-aminomethylcyclohexanecarbonamide, etc.), sulfatide, astaxanthin fatty acid diester (astaxanthin dilaurate, astaxanthin dimyristate, astaxanthin dipentadecanoate, astaxanthin diester) Palmitic acid ester, Astaxanthin dipalmitooleic acid ester, Astaxanthin diheptadecanoic acid ester, Astaxanthin dieraidic acid ester Astaxanthin diricinoleate, astaxanthin petrolinate, astaxanthin vacsenate, astaxanthin eleostearate, astaxanthin punicinate, astaxanthin licanoate, astaxanthin parinalate, astaxanthin gadorate, astaxanthin 5- Eicosenoic acid ester, astaxanthin 5-docosenic acid ester, astaxanthin cetolic acid ester, astaxanthin erucic acid ester, astaxanthin 5,13-docosadienoic acid ester, astaxanthin ceracholic acid ester, astaxanthin desenic acid ester, astaxanthin steric acid ester, astaxanthin dodecenoic acid Esther, Astaxanthin Diolei Acid esters, astaxanthin distearic acid esters, astaxanthin dieicosapentaenoic acid esters, astaxanthin didocosahexaenoic acid esters, astaxanthin dilinolenic acid esters, astaxanthin dilinolenic acid esters, astaxanthin diarachidonic acid esters, etc.), astaxanthin diglycerophosphates (astaxanthin diesters) Glycerophosphate, Astaxanthing lyserophosphate palmitic acid, Astaxanthing lyserophosphatidylcholine palmitic acid, Astaxanthing lyserophosphatidylcholine DHA, Astaxanthing lyserophosphatidylinositol palmitic acid, Astaxanthing lyserophosphatidylinositol DHA, Astaxanthin Luinositol linoleic acid, astaxanthin lyserophosphatidylcholine linoleic acid, etc., steviol glycosides, benzimidazole derivatives (1- (2-ethoxyethyl) -2- [1- (2- (4- (1- (4 , 4-Dimethyl-2-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- (4- (1- ( 2-Ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoic acid, ethyl 2- [4- (2- (4- (1- (2-ethoxyethyl)) Benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanate, 1- (2-ethoxyethyl) -2- [1- (2- (4- (1,1-dimethyl) -2-hydroxyethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 1- (2-hydroxyethyl) -2- [1- (2- (4- (1- (4,4-Dimethyl-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- ( 4- (1- (2-hydroxyethyl) benzoimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoic acid), alanine derivatives or salts thereof (N- [3-isopentyl- 4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl] -L-alanine, N- [3-isopentyl-4-methyl-2- [4- (3-Trifluoromethylbenzamide) benzoylimino] -3H-thiazoline-5-carbonyl] -2-methylalanine, N- [3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamide) Benzoylimino] -3H-thiazoline-5-carbonyl] -N-methyl-L-alanine), thiazoline derivatives or salts thereof (3-isopenes) Ru-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid, 4-isobutyl-3-methyl-2- [4- (3-trifluoro Methylbenzamide) benzoylimino] -3H-thiazoline-5-carboxylic acid, etc.), chlorpheniramine maleate, diphenhydramine hydrochloride, diphenylpyraline hydrochloride, carbinoxamine maleate, hydrocortisone butyrate, sulfated acidic mucopolysaccharides or salts thereof, sulfated Dextran or its salt, Fluoromethylhistidine or its hydrochloride, Histidine methyl ester or its hydrochloride, Licorice extract, Shikon extract, Ages extract, Propolis, Eye (Aiba) extract, Asenyaku (Asenyaku) extract, Avocado extract, Amadokoro Bamboo) extract, Amiga lily extract, Baimo (shellfish mother) extract, Igakouzo Na (biliary head) extract, Ibukitoranoo extract, turmeric (depressed gold) extract, Echinashi (Hosobamurasakibarengiku) extract, Auren (yellow chain) extract, Oguruma (turned over) extract, Hypericum (brothers cut) extract, Onigiri extract, Cassia extract, Camellia extract (weed) extract, Kawamidori extract, Kawamomogi extract (Kin Chin), watercress extract, Kenashi Sartorii rose (Tsumago, Yamakage) extract, Gentianana extract, Koki Sekko extract, Kohon (Kakimoto, Karasumoto) extract, Koryokyo (Koryo)姜) Extract, Gosho Strawberry (Bunbonko) Extract, Psychiaran Extract, Cherries Extract, Salvia (Sage) Extract, Diquitaris Extract, Linden Extract, Salamander Extract, Indian Bodaige Extract, Shukushamitsu (Sanjin, Shredded Sand) Ex , Juzudama extract, white minami extract, oleander extract, licorice extract, yarrow extract (milfoil) extract, hirohasenega extract, takasagorihigotai extract, takawarabi extract Extract, cypress rafji extract, tonin extract, chigaya extract, toga (winter coconut) extract, dokudami (ten-drug) extract, parsley (holland jellied) extract, sea bream (shitsuri, shishitsuri) extract, hamasuge (flavored licorice) extract, horsetail (hishi) Fruit) extract, belude oyster extract, sweet pea extract (south rattan) extract, bundo (mung bean) extract, sandalwood extract, butcher bloom extract, pansy extract, mosquito abragik (bitter potato) extract, mizurutennansho Tennansei extract, pheasant extract, miracle fruit extract, mulberry extract, peach extract, cornflower extract, yam willow extract, mistletoe (willow parasite) extract, yabukoji (purple gold beef) extract, sagebrush extract, mugwort ) Extract, Rosemary (Mannenrou) extract, Itohime extract, Fujuzumo extract, Tamajuzumo extract, Mizojuzumo extract, Urushigusa extract, Sardine beard extract, Akamok extract, Togemoku extract, Aqaba extract, Maruba akaba extract, Harigane extract, Dulse extract, Yuna extract, belladonna extract, cypress extract, harimille (crusted skin, cinnamon bark, cocoon leaf) extract, Aozulan extract, sakaneran extract, Sasabagin orchid extract (including varieties and origin species) extract, Nokosouekisu, evening primrose extract, Sen Ryukyu extract, apricot kernel extract, honeysuckle extract, angelica extract, fennel extract, peppermint extract, and the like.

Anti-seborrheic agent An anti-seborrheic agent can be added to the present invention. Specific examples of the antiseborrheic agent include chroman derivatives, pyridoxine or salts thereof and derivatives thereof, pyridoxal or salts thereof and derivatives thereof, pyridoxamine or salts thereof and derivatives thereof, sulfur, Asa extract, (Continuous) extract, Dutch mustard (watercress) extract, valerian extract (valerian root) extract, clematis extract, bear sebacekis, savonso extract, rosewood extract, horse chestnut extract, soybean (soybean) extract, milkflower extract (marigold) extract, Chinese yam Examples include extracts, yam extract, nosenhalen extract, dandelion poppy (sect winter flower, winter winter leaf) extract, japonica extract, giant kelp extract, hijirimen extract, primrose extract, haius banori extract and the like.

Antibacterial Agent An antibacterial agent can be added to the present invention. Specific examples of antibacterial agents include acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salashi powder , Iodine compounds, iodoform, 1-alkylcarbapenem compounds, N-substituted azepane derivatives or salts thereof, sorbic acid or salts thereof, propionic acid or salts thereof, salicylic acid or salts thereof, dehydroacetic acid, parahydroxybenzoic acid esters, 2 -Keto-3-deoxyoctanoic acid fatty acid esters, inositol deoxy derivatives (such as quercitol), inositol unsaturated derivatives (such as chonditol), inositol dimethyl ether, methyl inositol, inositol Ether, inosamine, deoxyinosadiamine, shikimic acid, quinic acid, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol , Thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, Chlorobutanol, isopropylmethylphenol, elemol, tiveverol, patchouli alcohol, nonionic surfactant (polyoxyethylene lauryl ether, polyoxyethylene nonyl) Phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride) , Methylrosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal violet, germal, photosensitive element 101, photosensitive element 201, photosensitive element 401, N-long chain acyl basic amino acid derivative and acid addition salt thereof, Zinc oxide, hinokitiol, propolis, cucumber extract, agi extract, asunaro extract, alpinia extract, katsudai (suzukuku) extract, Inubiyu extract, Aogate Extract, Haribiyu extract, Ayuyu extract, Hagatetou extract, Hosonagabiyu extract, Enmeiso extract, Warbler extract, Usubasaicin extract, Oshusaishin extract, Halibut extract, Ominaeshi (losing soy sauce) extract, Kajikazura鈎) extract, Kahoku salamander (蜀椒) extract, chamomile extract, linden extract, red linden extract, yellowfin extract, caraway extract, betel extract, kumazasa extract, cranberry extract, celosia (chicken crown flower, hen crown) extract, Bay bay extract, Koushinbara (monthly flower) extract, Copaiba balsam extract, Yamazakura extract, Edhigashi extract, Miyaza cherry extract, Yoshino cherry extract, Kasami cherry extract, Kanza cherry extract, sugar beet Extract, Sarashina Soma (Hemp) Extract, Shikunshi (Mizumiko) Extract, Birch Extract, Cinnamon Extract, Sorrel (Acid Model) Extract, Dandelion Extract, Japanese Nezu (Pine Pine) Extract, Pepper Extract, Pepper Extract, Soka ( (Grass and fruit) extract, onion extract, chicory extract, ginseng (蕪 夷) extract, tsuruna (apricot) extract, tokon (root) extract, leek (yuzu) extract, leek extract, peach extract, patchouli extract, ganbanana ( Sarcophagus, vines, cypress extract, cypress extract, pimenta extract, hirohaokinagusa (bald bald eagle) extract, blackberry extract, hop extract, makuri (marine herb) extract, magnolia sprengeri extract, mizokakushi (half-sided lotus) Extract, Honey Bee Extract, Murasaki (purple) Ex , Moso bamboo extract, pokeweed (commercial land) extract, yucca extract, crocodile extract, lavender extract, forsythia extract, cinnabar forsythia extract, lobster extract, tochaka extract Extract, Hirohanohitusa extract, Usohitoexa extract, Iroro extract, Shige extract, Alame extract, Tamaitake extract, Tambanori extract, Katanari extract, Sakuranori extract, Fujimatsumo extract, Kawamozuku extract, Aokawa Mozuku extract, Himekawa Mozuku extract, Yakuchi Examples include extracts.

Blood flow promoter / vascular stimulator A blood flow promoter / vascular stimulator can be added to the present invention. Specific examples of blood flow promoters and vascular stimulants include tocopherol or salts thereof and derivatives thereof, tocotrienol or salts thereof and derivatives thereof, cephalanthin, carpronium chloride, eugenol derivatives (acetyleugenol, methyleugenol, methylisoeugenol, ethyl Eugenol, Ethylisoeugenol, Eugenol salicylate, etc.), Minoxidil, Pepper tincture, Nonyl acid vanillamide, Cantalis tincture, Pepper tincture, Pepper oil, L-menthol, Camphor, Benzyl nicotinate, Cinnarizine, Trazoline, Acetylcholine, Verapamil, Itamol , Α-borneol, cyclandelate, nonyl acid wallenylamide, capsaicin, gingerone, assembly extract, garlic extract, carrot , Aloe extract, gentian extract, touki extract, ashitaba (tomorrow leaves) extract, arnica extract, duckweed (three ridges) extract, himewei extract, toucan extract (coconut extract), oyster extract, salmon extract, kina extract, goldfish extract, pine moth (Horse whip grass) extract, gubijinsou extract, kohone (river bone) extract, burdock (gyudon, beef coconut) extract, scallop (bamboo belly) extract, syringen ginger extract, ginger extract, ginger ) Extract, Hawthorn Extract, Assembly (Drug) Extract, Tanjin (Danjin) Extract, Thyme Extract, Chikutsutsuninjinjin (Takebushi Ginseng) Extract, Tsurudokudami (What Noodles) Extract, Tsurunjinjin (Yutabasan) Extract, Chili Pepper (Banban) Extract, touki (toll) extract, Japanese hornworm extract (Sadako), Natsumikan extract, elderberry (bone grafting) extract, hazelnut (coconut) extract, ashidokoro (roth root) extract, mint (light load, thin load leaf) extract, Hamabou Fu (hama wind) extract, Higotai extract, Fujimodoki (Chojizakura, Aoihana) extract, Black currant extract, Bodaiju (Aoki tree) extract, Merirot extract, Wintersweet extract, Japanese jelly extract, Hibiscus extract, Rosehip extract and the like.

Antiandrogen Agent An antiandrogen agent can be added to the present invention. Specific examples of antiandrogens include follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendron, 4 ', 5,7-trihydroxy-8-prenylflavanone, 4', 5,7-trihydroxy-8 -Prenyl flavone, 3,3 ′, 4 ′, 5,7-pentahydroxy-8-prenyl flavone, nicorandil, cyclosporine and the like.

Structural proteolytic enzymes (matrix metalloproteases such as elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme) activity inhibitor / structural protein Decomposition enzyme expression inhibitor The present invention includes a matrix of structural proteolytic enzymes (elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme, etc. A metalloprotease) activity inhibitor / structural protease inhibitor can be added. Specific examples of structural protease inhibitors) and structural protease inhibitors include adenine derivatives (butanetriol-9-adenine and its phosphate adduct, propanediol-9-adenine and its phosphate adduct, Pentanetriol-9-adenine and its phosphate adducts), carbostyril derivatives or salts thereof, dicarboxylic acids (glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, 1,9-nonamethylenedicarboxylic acid) Acid, 1,10-decamethylenedicarboxylic acid), rosmarinic acid, ursolic acid, oleanolic acid, hydroxamic acid derivative, esculetin derivative, anthocyanidins, nordihydroguaiaretech acid, 20-carboxy-16-hydroxy-21-nor- 5 α-7,9 (11) -lanostadien-3,24-dione, ubiquinone, plastakino , Juglone, shikonin, quinizarin, alizarin, abietin, levopimaric acid, betulin, α-amylin, catechin compounds (catechin, epigallocatechin, epigallocatechin gallate, epicatechin gallate, catechin rhamnopyranoside catechin, etc.) , Diisopropyl fluorophosphate, (2R, 6R) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate, N, N'-bis- [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydroxyheptanedicarboxylic acid-1,7-diamide, (2R, 6R)- 2,6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) Dimethyl heptane-1,7-dicarboxylate (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N'-bis [(1S, 2R) -2- Hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [( 1S, 2R) -2-Hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [( 1S, 2R) -2-Hydroxyindan-1-yl]-(2R, 6R) -2,4,6-trihydroxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R ) -2-Hydroxyindan-1-yl]-(2S, 6S) -2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, (2S, 6S) -2,6-dihydroxy -4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate, (2S, 6S)- 2,6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) Dimethyl heptane-1,7-dicarboxylate, (2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N'-bis [ (1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, 3-[[4- (4-Fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclopentyl) -amino] -propionic acid, 4- [4- (4-fluorophenoxy) -benzenes Sulfonylamino] -tetrahydropyran-4-carboxylic acid hydroxyamide, 4- [4- (4-chlorophenoxy) -benzenesulfonylmethyl] -tetrahydropyran-4-carboxylic acid hydroxyamide, 3-[[4- (4-fluoro Phenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclobutyl) -amino] -propionic acid, 4- (4′-chlorobiphenyl-4-yl) -2- [2- (1,3-dioxo-1, 3-Dihydroisoindol-2-yl) -ethyl] -4-oxobutyric acid, 1- [4- (4-fluorobenzyloxy) -benzenesulfonyl] -2-hydroxycarbamoylpiperidin-3-yl) -isopropyl carbamate Ester, 2- [4- (4-Fluorophenoxy) -benzenesulfonylamino] -N-hydroxy-2-methylpropionamide, 3- [4- (4-Fluorophenoxy) -benzenesulfonyl] -2, N-dihydroxy Propionamide 3- (4-Phenoxybenzenesulfonyl) -7-oxabicyclo [2.2.1] heptane-2-carboxylic acid hydroxyamide, (4-benzylbenzyl)-[2- (2,2-dimethyl-1-methylcarbamoylpropyl) Carbamoyl) -4- (4'-fluorobiphenyl-4-yl) -butyl] -phosphinic acid, 2-amino-3- [4- (4-fluorophenoxy) -benzenesulfonyl] -N-hydroxypropionamide, N -Hydroxy-2- (4-phenylpiperidine-1-sulfonyl) -acetamide, Iris japonicum extract, Diptera (summer hay) extract, Greater crape myrtle (Banaba) extract, Large hawthorn extract, Hawthorn (Yamako) extract, Calahoo ) Extract, guava extract, trash extract (gomi-cho) extract, shasenso extract, rose rose extract, hypericum perforatum extract, chickweed extract Tainokozuchi (cow knee) extract, Honoki (Japanese Kokaku, Park) extract, American grape extract, European grape extract, Yama Grape extract, Misaki psycho (Shibahu) extract, Ogon extract, Hypericum extract, Clara extract, Mulberry extract, Keihi extract, Gennoshoco Extract, Comfrey extract, Salvia extract, Elderberry extract, Bodaiju extract, Buttonpi extract, Aozuran extract, Sakaneran extract, Sasabagin orchid extract, Chinese cabbage extract (including varieties and origins), Aonorus agave extract, Sisal extract, And so on.

Structural protein synthesis promoter A structural protein synthesis promoter can be added to the present invention. Specific examples of the structural protein synthesis accelerator include ethanolamine derivatives, pentoxyphyllin, serine derivatives, geraniol, crocetin, methyl 4- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-4- (3, 5,5-Trimethylhexyloxy) methyl benzoate, methyl 4-cyclohexylmethoxy-2-hydroxybenzoate, methyl 4- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4- (3,7-dimethyl-6 -Octenyloxy) methyl 2-hydroxybenzoate, ethyl 3- (2-ethylhexyloxy) -5-hydroxybenzoate, methyl 5- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-5 -(3,5,5-trimethylhexyloxy) methyl benzoate, methyl 5- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4-N-hexyloxy-2-hydroxy Methyl benzoate, methyl 2-hydroxy-4-N-octyloxybenzoate, methyl 4-N-decyloxy-2-hydroxybenzoate, methyl 5-N-hexyloxy-2-hydroxybenzoate, 4- (2 -Ethylhexyloxy) -2-hydroxybenzoic acid, 2-hydroxy-4- (2,5,5-trimethylhexyloxy) benzoic acid, 4-cyclohexylmethoxy-2-hydroxybenzoic acid, 4- (2-cyclohexylethoxy) 2-hydroxybenzoic acid, 4- (3,7-dimethyl-6-octenyloxy) -2-hydroxybenzoic acid, 3- (2-ethylhexyloxy) -5-hydroxybenzoic acid, 5- (2-ethylhexyl) Oxy) -2-hydroxybenzoic acid, 5- (2-ethylhexyloxy) -2-hydroxybenzoic acid, 2-hydroxy-5- (3,5,5-trimethylhexyloxy) benzoic acid, 5- (2-cyclohexyl) Ethoxy) -2-hydroxybenzoic acid, 4-N-hexyl Xyl-2-hydroxybenzoic acid, 5-N-hexyloxy-2-hydroxybenzoic acid, 2-hydroxy-4-N-octyloxybenzoic acid, 4-N-decyloxy-2-hydroxybenzoic acid, N- (2 -Hydroxyethyl) -4- (2-ethylhexyloxy) -2-hydroxybenzamide, N-ethyl-4- (2-ethylhexyloxy) -2-hydroxybenzamide, 2-acetoxy-4-cyclohexylmethoxybenzoic acid, 4- Sodium (2-ethylhexyloxy) -2-hydroxybenzoate, methyl 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoate, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoate, 5-[(2E) -3,7 dimethyl-2,6-octadienyloxy] -2-hydroxybenzoate Ethyl 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoate, 3- [ 2E) -3,7-dimethyl-2,6-octadienyloxy] -5-hydroxybenzoate, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -3 Ethyl 4-methoxybenzoate, methyl 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzoate, 4-[(2E) -3 , 7-Dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid (2E) -3,7-dimethyl-2,6-octadienyl, 4-[(2E) -3,7-dimethyl-2 , 6-Octadienyloxy] -2-hydroxybenzoic acid, 5-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -5-hydroxybenzoic acid Acid, 2-hydroxy-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4-[(2E) -3,7-dimethyl -2,6-octadienyloxy] -3-methoxybenzoic acid, 2-acetoxy-4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, N- (2 -Hydroxyethyl) -4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzamide, 4-[(2E) -3,7-dimethyl-2,6- Octadienylamino] -2-hydroxybenzoic acid, dimethyl-2,6-octadienyloxybenzoic acid, N- (2-hydroxyethyl) -4-[(2E) -3,7-dimethyl-2,6 -Octadienyloxy] -2-hydroxybenzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienylamino] -2-hydroxybenzoic acid, 3-dodecyloxybenzoic acid, 3- (12-hydroxydodecyloxy) benzoic acid, 4-dodecyloxybenzoic acid, 4- (12-hydroxydodecyloxy) benzoic acid, 3- (12-hydroxyoctadecyloxy) benzoic acid, 4- (12-hydroxyoctadede Siloxy) benzoic acid, 3- (11-hydroxyundecyloxy) benzoic acid, 4- (11-hydroxyundecyloxy) benzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadi Enyloxy] benzoic acid, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, 3-[(2E, 6E) -3,7,11-trimethyl-2, 6,10-dodecatrienyloxy] benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4- [3,7- Dimethyl-9- (2,6,6-trimethyl-1-cyclohexen-1-yl) -2,4,6,8-nonatetraenyloxy] benzoic acid, 4- [3,4-dihydro-2,5 , 7,8-Tetramethyl-2- (4,8,12-trimethyltridecyl) -2H-1-benzopyran-6-oxy] benzoic acid, 4-[(2E, 6E) -3,7,11- Trimethyl-2,6,10-dodecatrienyloxy] benzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzamide, 4- (2-methyl-2-bu Tenenyloxy) benzamide, 4- (2-ethylhexyloxy) benzamide, 4-dodecyloxybenzamide, 4- (12-hydroxydodecyloxy) benzamide, 4- (12-hydroxyoctadecyloxy) benzamide, 4- (11-hydroxyundecyl) Oxy) benzamide, 4- (10-hydroxydecyloxy) benzamide, 4-isostearyloxybenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2, 6,10-dodecatrienyloxy] benzamide, N, N-dimethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzamide, N, N -Di [(2E) -3,7-dimethyl-2,6-octadienyl] -4-aminobenzamide, 4- [N'-methoxycarbonyl-N-[(2E) -3,7-dimethyl-2,6 -Octadienylamino] benzamide, 4- [N-acetyl-N-[(2E) -3,7-dimethyl-2,6-oct Dienyl]] aminobenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, N , N-diethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, pea extract, Tosakamodoki extract, Ikanoashi extract, Hosoivo Nori Extract, Novonori Extract, Igis Extract, Keigi Extract, Harigi Extract, Hanegisu Extract, Usuba Watanagi Extract, Moray Togusa Extract, Fuyugusa Extract, Willow Willow Extract, Willow Tree Extract, Moyuyurena Extract, Vulgaris Extract, Mosayanagi Examples include extract, Sasabayana chinori extract, wasabi extract, merbou extract and the like.

Mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitor A mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitor can be added to the present invention. Specific examples of mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitors include anacardic acid or derivatives thereof (6-pentadecatrienylsalicylic acid methyl ether, 6-pentadecatrienylsalicylic acid ethyl ether, 6-pentadeca Trienyl salicylic acid propyl ether, 6-pentadecatrienyl salicylic acid butyl ether, 6-pentadecatrienyl salicyl alcohol methyl ether, 6-pentadecatrienyl salicyl alcohol ethyl ether, 6-pentadecatrienyl salicyl alcohol propyl ether, 6- Pentadecatrienyl salicyl alcohol butyl ether, 6-pentadecatrienyl salicylaldehyde methyl ether, 6-pentadecatrienyl salicylaldehyde ethyl ether, 6-pentadecatrienyl salicyl aldehyde Hydropropyl ether, 6-pentadecatrienyl salicylaldehyde butyl ether, 2-methyl ether-6-pentadecatrienyl cinnamic acid, 2-ethyl ether-6-pentadecatrienyl cinnamic acid, 2-propyl ether-6 -Pentadecatrienyl cinnamate, 2-butyl ether-6-pentadecatrienyl cinnamate, 2-methyl ether-6-pentadecatrienyl cinnamate alcohol, 2-ethyl ether-6-pentadecatrienyl cinnamate Skin alcohol, 2-propyl ether-6-pentadecatrienyl cinnamon alcohol, 2-butyl ether-6-pentadecatrienyl] cinnamon alcohol), polyisoprenylated benzophenone derivatives (garcinol, isogarcinol, xantho) Thymol, isoxanthothymol, gucciferon, etc.), Ikarisou extract, Yachima Taikiso Inyo-kaku extract, Narco lily extract, Snapper extract, Yellow orchid extract, Oshida extract, Onji extract, Spruce extract, Crow birch extract (half-summer) extract, pheasant extract Skin) extract, goshuyu extract, senega extract, sendan extract, tamarind extract, tarragon extract, ginkgo biloba extract, bee extract, daisy extract, mirabaran extract, himebara extract, Mockin Extract, Laurel Extract, Yab Cycad Extract, Anaaaosa Extract, Macrocystis Integrifolia Extract, Neocities Ruetkeana Extract, Nettle Extract, Pterosa Extract, Kata Duck Extract, Yatabegusa Extract, Primrose extract, Ezotsunomata extract, Totsunomata extract, Fusaiwata mushroom extract, Hanemo extract, Mill extract, Chromel extract, Nagamil extract, Hiramil extract, Matsumo extract, Okinawa mozuku extract, Mozuku extract, Fukuronori extract, Kajime extract, Fukurofunori extract, Makuhori extract, grape leaves Examples include extracts, salamander extracts, and astragalus extract.

Mucopolysaccharide synthesis promoter A mucopolysaccharide synthesis promoter can be added to the present invention. Specific examples of mucopolysaccharide synthesis promoters include stilbene derivatives or salts thereof, morgin or salts thereof and derivatives thereof, N-acetylglucosamine, flax extract, cinnamon extract, mulberry extract, scotch extract, breadfruit extract, hirakotoji extract , Kotojitsu no Mata Extract, Yaleus Banori Extract, Kagiosu Banori Extract, Susius Banori Extract, Amiaosa Extract, Nagaaosa Extract, Hosobanosakamodoki Extract, Hirohatosakamodoki Extract, Yatsudegatatosakamodoki Extract, Kurotosakamodoki Examples include extract, nematode salamander extract, Yusora extract, Echikinosa salamander extract, nankaitosakamodoki extract, Himetosakamodoki extract and the like.

Intercellular lipid production promoter / intercellular lipid state improver An intercellular lipid production promoter / intercellular lipid state improver can be added to the present invention. Specific examples of intercellular lipid production promoters and intercellular lipid state improving agents include phospholipids (phosphatidylethanol, phosphatidylcholine, phosphatidyltriethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylglycerin, phosphatidylinositol, diacylphosphatidylcholine, diacylphosphatidylethanol Amine, diacylphosphatidylinositol, diacylphosphatidylserine, 1-cysteinylphosphatidic acid, 2-cysteinylphosphatidic acid, 1-glutathionylphosphatidic acid, 2-glutathionylphosphatidic acid, 1-azelaoylphosphatidic acid, 2- Azela oil phosphatidic acid, 1-hydroxyacyl phosphatidic acid, 2-hydroxyacyl phosphatidic acid, ceramide, glucosyl Ceramide, Galactosylceramide, Cerebroside, Phosphatidylglucosylacylglycerol, N-oleoylsphingosine, N- (12-hydroxyoctadecanoyl) sphingosine, N- (16-hydroxyhexadecanoyl) sphingosine, N-salicyloylphytosphingosine, Sphingomyelin, soybean lecithin, egg yolk lecithin, etc.), sterins (cholesterol, dihydrocholesterol, cholesteryl stearate, cholesteryl hydroxystearate, macadamia nut oil fatty acid cholesteryl, β-sitosterol, stigmasterol, campesterol, ergosterol, 5-dihydro Ergosterol, phytosterol, 25-hydroxycholesterol, 26-hydroxycholesterol, 19-hydroxycholesterol, 22-ke Tocholesterol oxime, 6-ketocholesterol and 7-ketocholesterol or their derivatives), N-acetylneuraminic acid (sialic acid), N-glucosolneuraminic acid, gangliosides (gangliotriose, gangliotetra Ose, globotetraose, neolactotetraose, neolactohexaose, neolactooctaose, etc.), oligosulfated hyaluronic acid, hydroxytamoxifen compounds, glyceroglycolipids, pentoxyphyllin, 3-deazaadenosine, carboxamide derivatives , Inositol polyamines, Sialic acid, Triterpenic acid derivatives, Lactose, Lactosamine derivatives, Sulfated chitin derivatives, Albumin, Panax ginseng extract, Tochiban ginseng extract, Tiger lily extract, Sasayuri extract, Hakata Yurieki And dairy extract.

Keratin solubilizer and stratum corneum peeling accelerator A keratolytic agent and stratum corneum peeling accelerator can be added to the present invention. Specific examples of keratolytic agents and stratum corneum exfoliation accelerators include tropolone and its derivatives, resorcin, lactic acid, urea, salicylic acid, guanidine, ethanolamine, kikarasuuri extract, fenugreek extract, wisteria bean extract, and lentil extract. Chickpea extract, mungbean extract and the like.

Plasminogen activator antagonist inhibitor A plasminogen activator antagonist inhibitor can be added to the present invention. Specific examples of the plasminogen activator antagonist inhibitor include rabbit daisy extract, canamgra extract, caladium extract, raspberry extract and the like.

Maillard reaction inhibitor A Maillard reaction inhibitor may be added to the present invention. Specific examples of Maillard reaction inhibitors include aminoguanidine, flavanones (naringin, naringenin, liquiritin, liquiritigenin, digallic acid, luteoic acid, ellagic acid, chlorogenic acid, glucogallin, tetralin, hamamelitannin, gallic tannin, tannic acid, Geraniin, gallic acid, galloyl gallic acid, ellagitannin, hexagalloyl glucose, heptagalloyl glucose, tetragalloyl glucose, trigalloyl glucose, pentagalloyl glucose, digalloyl quinic acid, trigalloyl quinic acid), 2-hydroxyphenylalkylamine Derivatives or salts thereof, phenylpropenoic acid derivatives (3- [2,3-bis (methoxymethoxy) phenyl] propenoic acid, 7- (4-hydroxy-3-methoxyphenyl) hepta-2,4,6-trienoic acid, 3- (3,5-dimension Xyl-4-hydroxyphenyl) propenohydrazide, N'-isopropylidene-3- (2-methoxyphenyl) propenohydrazide, etc.), citric acid or its salts, gypsum extract, sandalwood extract, red clover extract , Persimmon (including persimmon) extract, mulberry extract, Hypericum perforatum extract, camellia extract, garrega extract, yaba santa extract, rose hip extract, asunaro extract, itadori extract, yakuya extract, caeca extract, birch extract, hawthorn extract, Achillea millefolium extract, cod extract, tortilla extract, tortilla extract, buckwheat extract, hiba extract, grape extract, red willow extract, mugwort extract, karin extract, mokka extract, Roman chamomile extract, etc. I can get lost.

Testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promoter A testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promoter can be added to the present invention. Specific examples of testosterone 5α reductase activity inhibitor, hair papilla activator and hair growth promoter include γ-amino-β-hydroxybutyric acid esters (γ-amino-β-hydroxybutyric acid methyl ester, γ-amino-β- Hydroxybutyric acid ethyl ester, γ-amino-β-hydroxybutyric acid propyl ester, γ-amino-β-hydroxybutyric acid butyl ester, γ-amino-β-hydroxybutyric acid ethylhexyl ester, γ-amino-β-hydroxybutyric acid hexadecyl ester, γ-amino-β-hydroxybutyric acid lauryl ester, γ-amino-β-hydroxybutyric acid stearyl ester, γ-amino-β-hydroxybutyric acid oleyl ester, γ-amino-β-hydroxybutyric acid benzyl ester, γ-amino-β- Hydroxybutyric acid phenyl ester, γ-amino-β-hydroxybutyric acid ethyl glycol ester, γ-amino-β-hydroxy Butyric acid sorbitol ester, γ-amino-β-hydroxybutyric acid polyoxyethylene glycol ester, γ-amino-β-hydroxybutyric acid glycerin ester, etc.), amine oxides (oleyl dimethylamine oxide, stearyl dimethylamine oxide, palmityl dimethylamine oxide) , Myristyl dimethylamine oxide, lauryl dimethylamine oxide, dimethyl lauryl ethoxyamine oxide, dihydroxyethyl lauryl amine oxide, coconut oil alkyl dimethylamine oxide, etc.), alkyl betaines (coconut oil fatty acid amide propyl betaine, coconut oil alkyl betaine, lauryl dimethyl) Aminoacetic acid betaine, lauric acid amidopropyl betaine, lauryl hydroxysulfobetaine, 2-alkyl-N-carboxymethyl-N-hydroxy Cyethyl imidazolinium betaine), pyrimidine-N-oxide derivatives (2-amino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-6- (1-pyrrolidinyl) Pyrimidine-3-oxide, 2-amino-4-methyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-6- [1- (4-methylpiperazinyl)] pyrimidine-3- Oxide, 2-amino-4- (1-hexahydroazepinyl) -6-methylpyrimidine-1-oxide, 2-amino-4-dimethylamino-6-methylpyrimidine-1-oxide, 2-amino-4 -Allylamino-6-methylpyrimidine-1-oxide, 2-amino-4-benzylamino-6-methylpyrimidine-1-oxide, 2-amino-4,5-methyl-6-piperidinopyrimidine-3-oxide 2-amino-4-ethyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-5-nitro-6-piperidinopyrimidine-3-oxy Sid, 2,5-diamino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino -4-methyl-5-piperidino-6- (1-pyrrolidinyl) pyrimidine-3-oxide, 2-methyl-4-amino-6-piperidinopyrimidine-3-oxide, 2-methyl-4-amino-5 -Bromo-6- (1-pyrrolidinyl) pyrimidine-3-oxide, 2-methyl-4-amino-5-nitro-6-piperidinopyrimidine-3-oxide, 2-methyl-4,5-diamino-6 -Piperidinopyrimidine-3-oxide, 2-methyl-4-amino-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-6-piperidinopyrimidine-3 -Oxide monohydrochloride, 2-acetylamino-4-methyl-6-piperidinopyrimidine-3-oxide, 2,4-diamino-6-phenoxypyrimidine-3-oxide, 2,4-diamino-6- ( 2,4-dichloropheno C) Pyrimidine-3-oxide, 2,4-diamino-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitroso-6- (2,4-dichloro) Phenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2 , 4-Dichlorophenoxy) pyrimidine-3-oxide, 2,4,5-triamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-bromo-6- (2 , 4-dichlorophenoxy) pyrimidine-3-oxide, etc.), p-menthane-3,8-diol, monoglyceryl-D-glucoside monotridecanoate, 1-oN-pentadecylglycero-D-glucoside, Glyceride sulfate such as monopentadecanoic acid glyceride sulfate, monopentadecyl glyceryl ether sulfate, 1-o-hexa Decyl-2-o-methylglycerin, 1-o-octadecyl-2-o-methylglycerin, 1-o-oleyl-2-o-methylglycerin, acetylcarnitine or its salt, geranylgeranylacetone, hydroxamic acid derivative or its salt , Gingerone glycoside, benzeneoxyacetic acid derivative ([5- [2- [1-phenyl-1- (3-pyridyl) methylideneaminooxy] ethyl] -7,8-dihydronaphthalen-1-yloxy] acetic acid ), Isorhamnetin-3-robinobioside, xanthone derivatives, proanthocyanidins (grape seed extract proanthocyanidins, apple-derived proanthocyanidins, pine-derived proanthocyanidins, purified procyanidin oligomers, procyanidin B-2, procyanidins B-2, procyanidins B-3 , Procyanidin C-1 etc.), arakashi extract, angelica extract, apricot , Hong anzu extract, Ichiyakusou (one medicinal herb) extract, Enishida extract, psyllium (carlet child, car forerunner) extract, Psyllium extract Striped anteater extract, ginseng extract, scallop extract, cucumber nut extract, camphor extract, kubeba extract, buckthorn extract, oyster extract ) Extract, Sanekazura extract, Vinankazura extract, Matsubusa extract, Colombo extract, Condurango extract, Sasanqua extract, Sweet potato extract, Sanebutona Mei (acid soy sauce) extract, Sandskon (Yamazu-root) extract, Potato extract, Shishigashira extract, Sanshishi extract, Coriander extract, Stevia extract, Takatodai extract (Daisen) extract, Tarayo (Oba winter blue, Ichiha tea, bitter tea, bitter lantern Tea) extract, taranum extract, oyster tree extract, nullde (penta) extract, Hakama Labosi (bone crushing) extract, spider crab extract, scented squirrel extract, stag beetle extract, boxweed extract (rice plant) extract, lizard carrot ( Participant) extract, mangosteen extract, myoga extract, melaroika extract, jachabushi extract, himeya sabushi extract, oyabe sabushi extract, yakuso extract, yamanookiki (yamabeki) extract, longan (long-eye meat) extract, locon (reed, reed) extract, Logwood Ex And lantana extract.

Hair matrix growth inhibitor / hair growth inhibitor A hair matrix growth inhibitor / hair growth inhibitor can be added to the present invention. Specific examples of hair matrix growth inhibitor / hair growth inhibitor include phthalazinones, benzoxazinones, phosphonic acid derivatives, cyproterone, 5α-androstene-3α, 17β-diol, medroxyprogesterone, norethisterone, methanolone, and ichihatsu (First) extract, ash extract, kanto extract, sangiko extract, silamo extract, sardine extract, scabbard fern extract, fritillary extract, honeysuckle extract, seaweed extract, yoremok extract and the like.

Hair swelling agent / hair protecting agent A hair swelling agent / hair protecting agent can be added to the present invention. Specific examples of the hair swelling agent / hair protecting agent include ethanolamine, urea, guanidine, silicones, blueberry extract, mango extract and the like.

Odorous substance eliminating agent An odorous substance eliminating agent can be added to the present invention. Specific examples of the odorous substance eliminating agent include Inondo extract, Elemi extract, vanilla bins extract, pine extract and the like.

Other Additive Ingredients Specific examples of ingredients derived from plant-based materials used as additives to the present invention include Aokazura (Seifu Fuji) extract, Aotenma extract, Akasuguri extract, Aquine (crust) extract, Aguay Guasu extract, Abiyu extract, Abiurana extract, Yellow sapote extract, Ylang ylang extract, phalaenopsis extract, Uba tea extract, Ezo suzuran extract, Unboku extract, Elderberry extract, Ohisano Yuki extract, Sasa no Yuki extract, Toucan cactus extract, Omiya catechu extract, Onoelan extract, Crab extract, Karaya extract, Garyu extract, Kawaratake extract, Candelilla extract, Canna extract, Kidachi pepper extract, Kimenkaku extract, Cabb extract, Kiraja saponaria extract, Ginseca Extract, kimbsen extract, guapeba vermelha extract, kugenumaran extract, gooseberry extract, crity river extract, curcrigo latifolia extract, black moth (rescue) extract, cucumber extract, sapotea mariyo extract, salmon berry extract, salamander extract , Cactus Cactus Extract, Cranberry Extract, Shunran Extract, Shozuk Extract, Shirobanatsuta Extract, Cinchona Sacylbra Extract, Swimberry Extract, Star Apple Extract, Sulgaran (Oran) Extract, Scots Pine Extract, Plexus Japanese butterfly extract, mistletoe extract, sennin cactus extract, senboku extract, elephant shoot extract, prunus extract, somamonoimoe , Dark sweet cherry extract, prickly pear extract, chocolate nostay extract, ginseng extract, tsukushi kaneran extract, tsuchiakebibi extract, tsuyugusa (duckweed) extract, duberry extract, scallop extract, tragacanth extract, triacan Sos extract, Neiseria berry extract, Rapeseed extract, Plover-dough extract, Pau-dose extract, Hakuru berry extract, Batata extract, Hamakakiran extract, Balata extract, Harcan orchid extract, Pecan nut extract, Chicknut extract , Brazilian carrot extract, Branjen extract, Frucereria extract, Blond psyllium extract, Hetsukaran extract, Henken extract, Berry extract, Persea extract, Pervianburg extract, Perez Kia Grandifolia extract, Boysenberry extract, Hosairan extract, Pouteria sapota extract, Pouteria rukuma extract, Hosobabarengiku extract, Whataberry berry extract, Masaransuba extract, Masheira de Boyi extract, Matta auryo extract, Mulberry extract , Green sapote extract, purple corn extract, megacansa optica extract, mokukirin extract, maple leaf extract, morero cherry extract, yakawa potato extract, cornflower mint extract, rulitama thisami (urajiro higotai) extract, red currant extract, Examples include plant extracts such as red pitaya extract, lemongrass extract, wax palm extract and logan berry extract.

  In addition, as specific examples of components derived from plant-based raw materials used as an additive to the present invention, Dunaliella genus Dunaliella extract, Kuwanomi genus Kuwanomimo extract, Volbox genus genus sunflower extract, Volbox genus Volbox extract, Palmera extract, Yotsumemo extract, Aomido genus Chrysanthemum extract, Vulgaris extract, Hibimidro spp. Genus Black Ivy Extract, Casanori Genus Casanori Extract, Mika Ichiki Extract, Collecaete Extract, Tsutsumi Mimo Extract, Duckweed Genus Duckweed Extract, Sayamidro Extract, Kunshomo Extract Green algae extract such as Sumiremo violet reed extract, Hosimidro extract, Fuchinasimidro extract Genus Isogawara extract, black moth genus black moth extract, mosquito genus mosquito extract, whip squirrel extract, scallop squirrel extract, squirrel squirrel squirrel extract, common squirrel genus extract, common squirrel genus genus Hiranamikurakura extract, Somerna spruce extract, Navarimo spruce extract, Chawomen spruce extract, Nagamatsu Genus Nagamatsumo extract, Niseft mozuku niseft mozuku extract, Futomozuku genus mozuku extract, Kuromo genus kuromo extract, Nisemo genus nisemozuku extract, Ichimegasa Ichimegasa extract, zelkova quail extract, Umibos genus Citrus genus Compositae extract, Haberomodo spp. Extract, genus Cyprus extract, genus genus genus extract, genus turmeric extract, genus chrome extract, chrysanthemum Brown algae extract such as Bucus spp. Milnobeni extract, Konahada spp. Sodegarami Sodegarami Extract, Hirohatamitaki Hirohatamitaki Extract, Tengusa Nambugusa Extract, Tengusa Kohira Extract, Tengusa Yohira Extract, Tengusa Kinukusa Extract, Billow hibishiro extract, Hibiro hibishiro extract, Rhizoma genus extract, Rhizome genus extract, Ryumon genus Ryumon extract, Ryumon genus Hera ryumon extract, Nisekarekigusa genus naruto Ganoderma spp. Centipede extract, Centipede spruce extract, Centipede spider extract, Centipede extract, Centipede extract, Centipede extract, Centipede extract Marubadara extract, Hiramitoki Hirakintoki extract, Matabouja Matabou extract, Kintoki Chabokintoki extract, Kintoki Kintoki extract, Kintoki Ginseng extract, Kintoki Tosaka pine extract, Kintoki Hamamatsu extract, Kintoki Fushikintoki extract, Kintoki Toki Tokiki extract Centipede extract, Kintoki spp., Kintoki sp. Pteridocarpus genus extract, Honoho genus Honoo extract, genus genus genus genus extract, genus genus Usuginu extract, Nikuhou Ganoderma genus extract, Venetian genus Venetianago extract, Suscabeni genus Suscabeni extract, Okamuragusa porcupine extract, Isomocca isomocca extract, Kizinogi genus extract, Isodantsu isodantsu extract, Atsunori genus Atsubanori extract, Ogonori genus Mizoogonori extract, Ogonori genus Beniogonori extract, Ogonori sp. Ogonori genus Ogonori extract, Ogonori genus tsutsuginu extract, Ogonori genus Ogonori extract, Ogonori Kubireogonori extract, Ogonori genus Mosaogonori extract, Ogonori genus Nukabanori extract, Namiiwatake spp. Goat's extract, Taogi's genus Hanasakura extract, Fukutsunagi genus Fukutsunagi extract, Fukutsunagi spp. , Benifukuronori genus Benifukuronori extract, Villus spp. Nori Egonori Extract, Egonori Futogigi Extract, Saeda Saeda Extract, Chirimomiji Chiri Momiji Extract, Habutaenori Extract, Coniferous Extract, Suzushironori Extract, Usbeni Usbeni Extract, Hasujiginu Hasujiginu Extract, Nagakonohigani Extract Genus Sugiginu extract, Sugiginu genus Atsubasjiginu extract, Heius banori Kagious banori extract, Heius banori genus Yaleus banori extract, haius banori genus Suus banori extract, haius banori genus euus banus extract, genus genus genus genus Ayanishiki extract, Ayaginu Ayaginu extract, Dadia Enashida extract, Shimadadia Isohagi extract, Shimadadia Shimadadia extract, Dajimodoki daji Modoki extract, Makuri genus extract, Hanegusa genus extract, Hanegusa genus extract, Kozanemo genus Kozanemo extract, Kozanemo genus Isomurasaki extract, Kozanemo genus Hozo moss extract, Himego genus Himegoke extract, Himego genus Kurohegoshi extract Hyodosig genus Hyodosigusa extract, Hyodosig genus Usubahiodoshi extract, Isomegusus genus Isomegusa extract, Suginassa genus Sugenashigusa extract, Isobasho genus Isobasho extract, Ideyugogome genus Yuukogome extract, Ochimomoku genus Ochichimokuzhizuzuri zukisuji Red algae extract, Shajikumo extract, Shiratamamo extract, Hoshitsurimo Hoshitsurimo extract, Rikunotamnusu extract, Flascus spp. , Axle algae extracts such as chabo flask extract and tripella extract, yellow algae extracts such as Hikarimo Hikarimo extract, and the like.

  Specific examples of ingredients derived from animal materials used as an additive to the present invention include chicken crown extract, cow, pig or human placenta extract, pig or cow stomach, duodenum, intestine, spleen extract or degradation product thereof, cow Or porcine brain tissue extract, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its degradation product or derivatives thereof, silk protein and Degradation products thereof or derivatives thereof, porcine or bovine blood cell protein degradation products (globin peptides), cattle or porcine hemoglobin degradation products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and degradation products thereof Derivatives thereof, skim milk powder and decomposition products thereof or derivatives thereof, lactoferrin or decomposition products thereof, egg component, fish meat Hydrolyzate, nucleic acid-related substance (ribonucleic acid, deoxyribonucleic acid), and the like.

  Specific examples of components derived from microbial raw materials used as additives for the present invention include yeast metabolites, yeast extract extracts, bacterial metabolites, bacterial extract extracts, metabolites such as fungi or mushrooms, actinomycetes metabolites, fungi Or extracts such as mushrooms, actinomycetes extract, natto metabolite, natto extract, rice fermented extract, rice bran (red rice cake, white birch) fermented extract, euglena extract or a decomposed product thereof, or their water-soluble derivatives, raw milk or defatted Examples include lactic acid fermented milk powder.

  Furthermore, any part, cell, tissue, organ, metabolite, etc. derived from a transgenic or cell fusion can be used as the plant, animal or microbial material. Furthermore, it is obtained by culturing cells of any site, cell, tissue, organ, etc., for example, cultured cells derived from each tissue (cultures derived from animals such as fibroblasts, Langerhans cells, macrophages, epidermal cells, hepatocytes, etc.) Cell etc.), undifferentiated cell group, cell group in the middle of differentiation, and their metabolites can also be used.

  Specific examples of ingredients of natural raw materials used as additives include inorganic salts (magnesium chloride, chloride) obtained from seawater such as deep seawater, for example, seawater salt, seawater dried product, Dead Sea or Atlantic Ocean or Pacific Ocean. Potassium etc.), sea mud or mud (Fango), for example, Italian mugo, German fungo, Eifel fungo, Freiburg fungo, etc. Sea mud or mud (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, Manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, natural smectite , Bentonite, hectorite and the like.

  Extracts derived from plant raw materials, animal raw materials, microbial raw materials, and other natural product raw materials used as additives are processed in a conventional manner according to the product type and form to be added (for example, pulverization, milling, Treatment, extraction, decomposition, fermentation or metabolic conversion by microorganisms, fractionation, purification, pressing, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. ) And arbitrarily select from various materials.

  The solvent used for the extraction may be selected in consideration of the intended purpose and type of the product to be provided, or the processing performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isopropanol are used. Lower alcohol such as butanol or hydrous lower alcohol, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1, 3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, 1,2-hexanediol, 1,5-hexanediol, 1,6-hexanediol, pentylene glycol, hexylene glycol, Polyhydric alcohols such as glycerin and polyethylene glycol (molecular weight 100 to 100,000) or hydrous polyhydric alcohols, Various organic solvents such as seton, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, carbon tetrachloride, phenol, toluene, etc., and acids (hydrochloric acid, sulfuric acid, It is desirable to use one or a mixture of two or more selected from nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.). However, when it is not preferable to contain a solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it may be used alone or in any mixture with water. It may be extracted after squeezing.

  Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. The temperature of the solvent can be arbitrarily set in the range of −4 ° C. to 100 ° C., but is preferably around 10 to 40 ° C. from the viewpoint of the stability of the components contained in the raw material. Further, the weight ratio of the solvent to the raw material can be arbitrarily set within the range of, for example, raw material: solvent 4: 1 to 1: 100, and a weight ratio of 1: 1 to 1:10 is particularly preferable.

  Decomposition mainly includes acid decomposition, alkali decomposition, enzyme decomposition, and high-temperature and high-pressure decomposition. In the decomposition with an acid, for example, it is preferable to use an inorganic acid or an organic acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, oxalic acid, hydrogen bromide, perchloric acid, and periodic acid. In the decomposition by alkali, for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, barium hydroxide, sodium carbonate, ammonium carbonate, calcium carbonate, magnesium hydroxide, sodium silicate, etc. are preferably used. In the decomposition with acid or alkali, the concentration, reaction time, reaction temperature, and the like can be arbitrarily set for the target raw material. In the enzymatic degradation, it is preferable to use an enzyme having a function of degrading proteins, polysaccharides, lipids or complexes thereof having an important function particularly with respect to cell structure, tissue structure, etc., for example, aminopeptidase, dipeptidase, dipeptide Peptidyl peptidase, tripeptidyl peptidase, carboxypeptidase, serine protease, trypsin, chymotrypsin, cysteine protease, thiol protease, papain, aspartate endopeptidase, metalloendopeptidase, bromelain, thermolysin, pronase, pepsin, rennin, pan Proteolytic enzymes (proteases) such as creatine, chymopapain, ficin, collagenase, elastase, amylase, takaamylase, cellulase, hemicellular Polysaccharide-degrading enzymes such as zectin, pectinase, polygalacturonase, dextranase, and planase, chicken egg white lysozyme, human lysozyme, papaya lysozyme, cabra lysozyme, barley lysozyme, zymolyce, lysozyme chloride, glucanase, chitinase Cell wall lytic enzymes such as In the degradation with an enzyme, the concentration, reaction time, reaction temperature, pH of the solution, etc. can be set arbitrarily, but it is particularly preferable to set the optimum value for the enzyme used.

  Fermentation or metabolic conversion by microorganisms can be performed by inoculating and growing at least one kind of microorganism on a raw material used as a substrate. Inoculation of microorganisms to the substrate can be done by adding microorganisms directly into the substrate, or by adsorbing them on a carrier such as alginic acid, polyvinyl, gelatin, etc., for example, in the form of fine beads composed of microorganisms and carrier. Further, it can be used by being fixed to the tube wall of the bioreactor. Fermentation or metabolic conversion by microorganisms is not particularly defined as a microorganism to be used, but can generally be defined as microorganisms other than pathogenic microorganisms that exhibit significant toxicity to living bodies. Examples of microorganisms to be used include microorganisms classified into yeasts: Aciculoconidium, Actonia, Aessosporon, Ambrosiozyma, Anthomyces, Apiotrichum, Arthroascus, Arxula, Ashbia, Ashbya, Asporomyces, Atelosaccharomyces Genus, Azymoprocandida, Babjevia, Ballistosporomyces, Bensingtonia, Blastobotrys, Blastodendrion, Blastoderma, Blastoschizomyces, Botryoascus, Botryozyma, Brettanomyces, Brettanomyces bruno Genus (Candida albicans, Candida amylolenta, Candida anomala, Candida boidinii, Candida entomaea, Candida etchellsii, Candida famata, Candida fermentati, Candida guilliermondii, Candida halophila, Candida krusei, Candida krusei, Candida krusei, Candida krusei, Candida krusei, Candida krusei Candida sake, Candida tropicalis, Candida versatilis, Candida vulgaris, etc.), Ca Stellania genus, Chlamydozyma genus, Chromotorula genus, Citeromyces genus, Cladosporium genus, Clavispora genus, Crebrothecium genus, Cryptococcus genus, Debaryomyces genus (Debaryomyces delbrueckii, Debaryomyces halotolerans, Debaryomyces hansenii genus, Debarymyces hansenii etc. Dipodascus, Eeniella, Endomyces, Endomycopsis, Eremascus, Eremothecium, Eutorulopsis, Fabospora, Fellomyces, Filobasidium, Galactomyces, Geotrichoides, Geotrichum, Guilliersen, Genus anomala, Hansenula kluyveri, Hansenula miso, Hansenula polymorpha, Hansenula wickerhamii, etc., Hypomyces, Issatchenkia, Kloeckera (Kloeckera brevis, Kloeckera fluoresceny, Kloeckera japonica, etc.) Etc.), Kockovaella genus, Kurtzmanomyces genus, Leucosporidium genus, Lipomy genus ces, Metschnikowia, Microanthomyces, Monilia, Monospora, Monosporella, Mrakia, Myceloblastanon, Mycocandida, Mycoderma, Mycotorula, Mycotoruloides, Myxozyma, Nadsonia, Nectaromyces, Nematospora , Ogataea, Oidium, Oospora, Oosporidium, Ochyporidium, Pachysolen, Parasaccharomyces, Paratorulopsis, Parendomyces, Petasopsora, Pichia , Procandida genus, Procandida genus, Proteomyces genus, Pseudomonilia genus, Pseudosaccharomyces genus, Pseudozyma genus, Rhodomyces genus, Rhodosporidium genus, Rhodotorula genus, Saccharomyces genus (Saccharomyces aceti, Saccharomyces cerasiy, , Genus Saccharomycodes, genus Saccharomycopsis, genus Saturnispora, genus Schizoblastosporion, Schizosaccha sp. Udeniomyces genus, Waltomyces genus, Willia genus, Willopsis genus, Wingea genus, Xanthophyllomyces genus, Yamadazyma genus, Zendera genus, Zygofabospora genus, Zygopichia genus, Zygosaccharomyces genus, Zymodebaryomyces genus and the like. Microorganisms classified as bacteria include Acetobacter genus (Acetobacter aceti, etc.), Achromobacter genus, Acidianus genus, Acidobacterium genus, Acidithiobacillus genus, Acrocarpospora genus, Actinoalloteichus genus, Actinocorallia genus, Actinokineospora genus, Actinomadspura genus, Actinomadspura Actinosynnema genus, Aerococcus genus, Aeromicrobium genus, Agrobacterium genus, Agromyces genus, Ahrensia genus, Alcaligenes genus, Alicyclobacillus genus, Alloiococcus spp. , Aureobacterium genus, Azotobacter genus, Bacillus genus (Bacillus brevis, Bacillus subtilis etc.), Bacteroides genus, Beneckea genus, Bifidobacterium genus (Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis etc.), Brachybacterium genus, Brevicillus, Brevundimonas, Burkholderia, Carnobacterium, Catellat genus ospora, Cellulomonas, Chainia, Chromobacterium, Chryseobacterium, Citrobacter, Clavibacter, Corynebacterium, Couchioplanes, Cryptosporangium, Curtobacterium, Dactylosporangium, Deinococcus, Delftia, Dermatia, Dermatia , Elytrosporangium, Enterobacter, Erwinia, Escherichia, Eubacterium, Excellospora, Exiguobacterium, Faenia, Flammeovirga, Flavobacterium, Flexibacter, Geodermatophilus, Globicatella, Gluconacetobaceto, Gluconacetobacter Genus, Gordonia, Halobacterium, Halococcus, Herbidospora, Hydrogenophilus, Hyphomicrobium, Hyphomonas, Intrasporangium, Janibacter, Jonesia, Kibdelosporangium, Kineopocusato, Kitasposatos, Kitasposatos, Kitasposatos Klebsiella, Kocuria, Kurthia, Lactobacillus (Lactobacillus rimae, Lactobacillus dive rgens, Lactobacillus carnis, Lactobacillus piscicola, Lactobacillus acidophilus, Lactobacillus amylophilus, Lactobacillus animalis, Lactobacillus brevis, Lactobacillus casei, Lactobacillus curvatus, Lactobacillus bulgaricus, Lactobacillus delbrueckii, Lactobacillus fermentum, Lactobacillus fructivorans, Lactobacillus fructosus, Lactobacillus helveticus, Lactobacillus hilgardii, Lactobacillus homohiochii, Lactobacillus kefiri, Lactobacillus malefermentans, Lactobacillus murinus, Lactobacillus paracasei, Lactobacillus paracasei subsp. tolerans, Lactobacillus parakefiri, Lactobacillus pentosus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus sakei, Lactobacillus confusus, Lactobacillus viridescens, Lactobacillus johnsonii, Lactobacillus viscosus, Lactobacillus fermentatae , Lactobacillus acidophil-aerogenes, Lactobacillus leichmannii, Lactobacillus gasseri, Lactobacillus bifidus, Lactobacillus jugurt, Lactobacillu s caucasicus, Lactobacillus arabinosus, Lactobacillus kunkeei, Lactobacillus nagelii, Lactobacillus fornicalis, Lactobacillus pentoaceticus, Lactobacillus xylosus, Lactobacillus minutus, etc.), Leuconostoc genus (Leuconostoc lactis, Leuconostoc dextranicum, Leuconostoc mesenteroides, Leuconostoc oenos, Leuconostoc paramesenteroides, Leuconostoc cremoris, Leuconostoc citrovorum, etc. ), Listonella, Lucibacterium, Luteococcus, Magnetospirillum, Marinilabilia, Marinospirillum, Mesorhizobium, Metallosphaera, Methylobacterium, Microbispora, Micrococcus, Microellobosporia, Micromonospora, Mycobacterium, Nocoides, Nocoides, Cardio, Genus, Nonomuraea, Nonomuria, Oceanospirillum, Ochrobactrum, Oerskovia, Oligella, Paenibacillus, Pediococcus (Pediococcus cerevisiae, Pediococcus pentosaceus, Pediococcus urinae-octocus, genus Pedococcus Genus, Pimelobacter sp Rhodococcus sp , Streptococcus faecalis, Streptococcus faecium, Streptococcus bovis, Streptococcus equinus, Streptococcus mutans, Streptococcus salivarius, Streptococcus thermophilus, Streptococcus agalactiae, Streptococcus mitis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus lactis, Streptococcus dysgalactiae, Streptococcus sanguis, Streptococcus acidominimus, Streptoco ccus avium, Streptococcus uberis, Streptococcus cremoris, Streptococcus diacetilactis, etc.), Streptomyces genus, Streptosporangium genus, Streptoverticillium genus, Terrabacter genus, Thermoactifinos genus, Thermobiso genus, Thermobimo genus Examples include the genus Thiosphaera, the genus Weissella, the genus Xanthobacter, the genus Xanthomonas, and the genus Zymomonas. Microorganisms classified as non-yeast ascomycetes, basidiomycetes or incomplete fungi include Allomyces, Amoebidium, Amorphotheca, Arthroderma, Ascoidea, Ascobolus, Ascodesmis, Aspergillus, Aureobasidium, Botryosphaeria Botryotinia sp Genus, Dothidea genus, Endogone genus, Entomophthora genus, Emericella genus, Eupenicillium genus, Eurotium genus, Exobasidium genus, Gibberella genus, Glomus genus, Graphiola genus, Gymnoascus genus, Harpella genus, Helicomyces genus, Helvella genus, Hemicarpenteles genus, Hyphochytrium genus, Hyphochytrium Hypocrea, Laboulbenia, Labyrinthula, Leptosphaeria, Leptosphaerulina, Lophodermium, Melanotaenium, Microascus, Microstroma, Medeololaria, Melampsora , Melamsporella, Morchella, Monascus, Monilinia, Mycospharella, Nannizzia, Nectria, Neolecta, Neurospora, Nodulosphaeria, Olpidium, Peziza, Penicillium, Perenospora, Pestopolisis Genus, Pneumocystis genus, Preussia genus, Pleospora genus, Puccinia genus, Pythium genus, Ravenelia genus, Rickia genus, Rhinocladiella genus, Rhizidiomyces genus, Rhizoctonia genus, Sclerocleista genus, Saprolegnia genus, Sclerotinia genus, Sclerotum genus, Septobasidium genus, Septobasidium genus Examples include Sporidiobolus genus, Stigmatomyces genus, Sydowiella genus, Talaromyces genus, Taphrina genus, Thraustochytrium genus, Tolyposporium genus, Trichoglossum genus, Trichoma genus, Ustilago genus, Verticillium genus, Xylaria genus and the like.

  In fermentation or metabolic conversion by microorganisms, in addition to various raw materials such as plant-based materials, animal-based materials, and other natural product-based materials, the growth and metabolism of microorganisms are regulated or activated, and special biosynthesis or degradation pathways are induced. In order to achieve this, various compounds can be added to the raw material. For example, as a carbon source, sugar, ethane such as glucose, fructose, galactose, sucrose, maltose, mannose, lactose, glycerin, starch, etc. , Hydrocarbons such as methane, propane, butane, formic acid, acetic acid, propionic acid, lauric acid, palmitic acid, fatty acids such as oleic acid, linoleic acid, linolenic acid, etc., nitrogen sources such as ammonium sulfate, ammonium hydrochloride, ammonium phosphate, etc. Ammonium salts, urea, uric acid, amino acids, etc. Vitamins and compounds containing potassium, calcium, magnesium, sodium, sulfur, phosphorus, chlorine, etc., as well as iron, copper, zinc, cobalt, nickel, boron, manganese, molybdenum, tin, selenium, silicon It is possible to further add compounds contained in the composition such as arsenic, vanadium, chromium and fluorine. In addition, the optimum temperature, oxygen supply amount, pH, pressure, etc. that affect the growth and metabolic activities of various microorganisms can be arbitrarily set according to the characteristics inherent to various microorganisms. Can be arbitrarily set within the range of 10 to 50 ° C., and the pH can be arbitrarily set within the range of 1 to 14.

  In fractionation or purification, generally known techniques can be used as appropriate. In addition to solvent extraction, for example, liquid chromatography (ion exchange chromatography, ion exclusion chromatography, affinity chromatography, gel filtration chromatography, size exclusion chromatography, etc.). Chromatography, hydrophilic adsorption chromatography, hydrophobic adsorption chromatography, ligand exchange chromatography, etc.) fractionation using a single column or multiple columns, dialysis with semipermeable membranes, crystallization and recrystallization of components. Examples thereof include crystallization, filter paper, membrane filter, ultrafilter, filtration using activated carbon, filter aid, etc., centrifugal separation and its application, fractional precipitation method, density gradient separation method such as density gradient sedimentation equilibrium method, and the like.

Specific examples of other components other than the above used as additives in the present invention include silicic anhydride, magnesium silicate, talc, kaolin, bentonite, hectorite, natural or synthetic smectite, stevensite, mica, mica titanium, oxy Inorganic pigments such as bismuth chloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, bengara, black iron oxide, gunjou, chromium oxide, chromium hydroxide, carbon black, calamine, Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate , Silicic acid Thorium hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide and other inorganic reducing agents , Redox agents such as thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate), 5-aminoorthocresol, 2-amino-4 -Nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene hydrochloride -2,5-diamine, nitroparaphenylenedia hydrochloride , Paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5- Dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium picrate, N , N′-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, Metaphenylenediamine, 5-aminoorthocreso sulfate 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, Nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine, catechol, diphenylamine, α -Naturol, hydroquinone, phloroglucin, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sodium sulfonate, dyes such as hematein, natural materials such as musk, civet, castrium, ambergris Animal flavors, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, kananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, corian Dell essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil, dairy perfume essential oil, tuberose essential oil, dichroic essential oil, orange flower essential oil, winter green essential oil, trubalsum essential oil , Buttery essential oil, rose essential oil, palmarosa essential oil, cocoon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot essential oil, peru balsam essential oil, boadrose essential oil, mellow essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil , Naroe essential oil, lemongrass essential oil, rosemary essential oil, vegetable fragrance such as Japanese mint essential oil, other synthetic fragrances, 5-amino-o-cresol, o-aminophenol, m-aminophenol, p-aminophenol 2,6-diaminopyridine, 5- (2-hydroxylethylamino) -2-methylphenol, N, N-bis (β-hydroxyl) -p-phenylenediamine sulfate, N, N-bis (2-hydroxy Ethyl) -p-phenylenediamine, p-nitro-o-phenylenediamine, p-phenylenediamine, m-phenylenediamine, N-phenyl-p-phenylenediamine, 2-hydroxy-5-nitro-2 ', 4'- Sodium diaminoazobenzene sulfate, toluene-2,5-diamine, 2- (2'-hydroxyethylamino) -5-aminotoluene, N, N-bis (β-hydroxyl) -p-phenylenediamine, N, N-bis (2-hydroxyethyl) -p- Henylenediamine sulfate, 5-amino-o-cresol sulfate, p-aminophenol sulfate, o-chloro-p-phenylenediamine sulfate, 2- (2'-hydroxyethylamino) -5-aminotoluene sulfate, 4,4'-diaminodiphenylamine sulfate, p-methylaminophenol sulfate, p-phenylenediamine sulfate, m-phenylenediamine sulfate, toluene-2,5-diamine sulfate, 2,4-diaminophenoxyethanol hydrochloride , Toluene-2,5-diamine hydrochloride, m-phenylenediamine hydrochloride, 2,4-diaminophenol hydrochloride, 3,3'-iminodiphenol, p-phenylenediamine hydrochloride, N-phenyl-p-phenylene Diamine hydrochloride, N-phenyl-p-phenylenediamine acetate, 1,5-dihydroxynaphthalene, toluene-3,4-diamine, p-methylaminophenol, N, N'-bis (4-aminophenyl) -2 ,Five- Amino-1,4-quinonediimine, o-aminophenol sulfate, 2,4-diaminophenol sulfate, m-aminophenol sulfate, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1 -Amino-4-methylaminoanthraquinone, nitro-p-phenylenediamine hydrochloride, 1,4-diaminoanthraquinone, nitro-p-phenylenediamine, piclamic acid, sodium picrate, 2-amino-5-nitrophenol sulfate, Resorcinol, nitro-p-phenylenediamine sulfate, p-nitro-o-phenylenediamine sulfate, p-nitro-m-phenylenediamine sulfate, red 2, red 3, red 102, red 104 ( 1) Red 105 (1), Red 106, Red 201, Red 227, Red 230 (1), Red 230 (2), Red 231, Red 232, Red 401 , Red 502, Red 503, Red 504, Red 5 06, Yellow 4, Yellow 5, Yellow 202 (1), Yellow 202 (2), Yellow 203, Yellow 402, Yellow 403 (1), Yellow 406, Yellow 407 , Orange 205, orange 207, orange 402, green 3, green 204, green 205, green 401, green 402, brown 201, purple 401, blue 1, blue 2, blue No. 202, Blue No. 203, Blue No. 205, Black No. 401, Red Cabbage Dye, Red Spider Dye, Catechol Tannin, Red Rice Dye, Akane Dye, Anato Dye, Ikumi Dye, Turmeric Dye, Enju Dye, Krill Dye, Amber Dye , Caramel, gold, silver, gardenia pigment, corn pigment, onion pigment, tamarind pigment, spirulina pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, grape skin pigment, marigold pigment, purple potato pigment, purple yam pigment , Lac dye, rutin and other pigments / colorants, avoca Oil, almond oil, fennel oil, egoma oil, olive oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber nut oil, safflower oil, shea fat, liquid shea fat, soybean oil, camellia oil , Corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, palm oil, beef tallow, lard, or hydrogenation of these oils Fats and oils such as products (hardened oil, etc.), beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc., liquid paraffin , Vaseline, paraffin, ozokelide, ceresin, microcristan Mineral oil such as water, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin Fatty acids such as natural fatty acids such as fatty acids, synthetic fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid, ethanol, isopyropanol, lauryl alcohol, Synthetic alcohols such as natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, 2-hexyldecanol, isostearyl alcohol, 2-octyldodecanol Alcohols such as isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyl decyl dimethyloctanoate, diisobutyl adipate, adipic acid 2-hexyldecyl, diheptylundecyl adipate, N-alkyl glycol monoisostearate, isocetyl isostearate, trimethylolpropane triisostearate, ethylene glycol diethyl hexanoate, neopentyl glycol diethyl hexanoate, cetyl 2-ethyl hexanoate, Triethylhexanoate trimethylolpropane, tetraethylhexanoate pentaerythritol, cetyl octoate, octyldodecyl gum Cetyl lactate, myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, aluminum stearate, magnesium stearate, zinc stearate, Metal soaps such as calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate, anionic surfactants (alkyl carboxylates, alkyl sulfonates, alkyl sulfates, alkyl phosphates) , Alkyl sulfate salts (sodium lauryl sulfate, potassium lauryl sulfate, triethanolamine lauryl sulfate, ammonium lauryl sulfate, sodium cetyl sulfate, stear Sodium sulfyl sulfate, secondary alcohol sulfate, alkyl ether sulfate (for example, polyoxyethylene lauryl sulfate triethanolamine, polyoxyethylene lauryl sodium sulfate), alkyl and alkyl allyl ether sulfate (N- Acyl methyl alanine salt, N-acyl glutamate, N-acyl methyl taurate, N-acyl isethionate, N-acyl glycine salt, alkyl phosphate, alkyl ether carboxylate, alkyl sulfonate, alkyl sulfosuccinate , Sodium polyoxyethylene lauryl ether sulfate, polyoxyethylene lauryl ether triethanolamine sulfate, polyoxyethylene lauryl ether ammonium sulfate, polyoxyethylene alkyl ether sodium sulfate, Polyoxyethylene alkyl ether sulfate triethanolamine, polyoxyethylene alkyl ether sulfate diethanolamine, polyoxyethylene alkyl ether ammonium sulfate, etc.), higher fatty acid alkylolamide sulfate, higher fatty acid ester sulfate (cured coconut oil fatty acid sodium glycerine sulfate) Etc.), polyoxyethylene alkyl ether carboxylic acid, polyoxyethylene alkyl allyl ether carboxylate, sulfated oil such as sulfated castor oil, mono or dialkyl or alkenyl phosphate ester salt, polyoxyethylene mono or dialkyl or alkenyl phosphorus Acid ester salts (sodium monolauryl phosphate, sodium isostearyl phosphate, arginine 2-hexyldecyl phosphate, 2-heptyl undecyl phosphate Sodium, sodium polyoxyethylene (4-10) lauryl ether phosphate
, Sodium monocetyl phosphate, arginine monomyristyl phosphate, sodium monooleyl phosphate, polyoxyethylene (2-10) potassium lauryl ether phosphate, sodium dioctyl phosphate, etc.), polyoxyethylene alkyl ether phosphate ester salt ( Polyoxyethylene lauryl ether phosphate, polyoxyethylene oleyl ether phosphate, polyoxyethylene cetyl ether phosphate, polyoxyethylene stearyl ether phosphate, polyoxyethylene alkyl ether phosphate, polyoxyethylene alkyl phenyl ether phosphate, etc.) , Sulfonate of higher fatty acid amide or sulfonate of higher fatty acid ester (α-olefin sulfonate, sodium N-myristoyl-N-methyltaurine, palm oil fatty acid methyltaurine Thorium, sodium lauroylmethyl taurate, etc.), alkylbenzene sulfonates (dodecylbenzenesulfonic acid, monoethanolamine dodecylbenzenesulfonate, diethanolamine dodecylbenzenesulfonate, triethanolamine dodecylbenzenesulfonate, sodium dodecylbenzenesulfonate, etc.), sulfosuccinate Acid salts (sodium diethylhexyl sulfosuccinate, sodium sulfosuccinate, disodium lauryl sulfosuccinate, disodium polyoxyethylene sulfosuccinate, disodium lauryl polyoxyethylene sulfosuccinate, disodium polyoxyethylene lauroyl ethanolamide ester sulfosuccinate, undecile Noylamidoethylsulfosuccinate, monolauroyl Noethanolamide polyoxyethylene sulfosuccinate sodium, sodium lauryl polypropylene glycol sulfosuccinate, etc.), N-acyl sarcosine salts (eg lauroyl sarcosine sodium, palmitoyl sarcosine sodium), higher fatty acid and amino acid condensates (N-acyl glutamate, N -Sodium stearoyl glutamate, potassium N-palmitoyl glutamate, sodium N-lauroyl-L-glutamate, disodium N-stearoyl-L-glutamate, sodium N-myristoyl-L-glutamate, sodium myristoyl methyl taurate, sodium palmitoyl methyl taurate, stearoyl Methyl taurine sodium, N-palmitoyl-β-alanine arginine, N-palmitoyl aspartate ditriethanolamine, etc.) Anionic surfactants such as fatty acid soaps such as oleate, suarenate, laurate and palmitate (examples of salts of anionic surfactant include alkali metal salts such as sodium salt and potassium salt, mono Ethanolamine salts, diethanolamine salts, triethanolamine salts, organic ammonium salts such as L-lysine salts, L-arginine salts, ammonium salts, etc.), quaternary ammonium salts (alkyltrimethylammonium chloride, cetylammonium chloride, Cetyl ammonium bromide, lauryl ammonium chloride, lauryl ammonium bromide, stearyl ammonium chloride, stearyl ammonium bromide, cetyl dimethyl ammonium chloride, cetyl dimethyl ammonium bromide, lauryl dimethyl ammonium chloride, stearyl dimethyl chloride Ammonium, lauryl trimethyl ammonium chloride, lauryl trimethyl ammonium bromide, stearyl dimethyl cetyl ditallow dimethyl ammonium chloride, dicetyl ammonium chloride, dicetyl ammonium bromide, dilauryl ammonium chloride, dilauryl ammonium bromide, distearyl ammonium chloride, odor Distearylammonium chloride, dicetylmethylammonium chloride, dicetylmethylammonium bromide, dilaurylmethylammonium chloride, dilaurylmethylammonium bromide, distearylmethylammonium chloride, distearylmethylammonium bromide, cetyltrimethylammonium chloride, odor Cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, lauric bromide Ryltrimethylammonium chloride, dialkyldimethylammonium chloride, dicetyldimethylammonium chloride, distearyldimethylammonium chloride, dicocoyldimethylammonium chloride, myristyldimethylbenzylammonium chloride, stearyldimethylbenzylammonium chloride, ethyl lanolin sulfate fatty acid aminopropylethyldimethylammonium chloride Cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, behenyltrimethylammonium chloride, behenyldimethylhydroxyethylammonium chloride, stearyldimethylbenzylammonium chloride, distearyldimethylammonium chloride, distearoylethylhydroxyethylmonium metasulfate, dicocoylethylhydroxyethyl moniou Metasulfate, dipalmitoylethylhydroxyethylmonium metasulfate, and cetyltriethylammonium methyl sulfate, alkyltrimethylammonium chloride, alkyldimethylbenzylammonium chloride, dialkyldimethylammonium chloride, alkyltrimethylammonium bromide, alkylpentaethoxyammonium chloride, ditallowdimethyl Ammonium chloride, ditallow dimethyl ammonium methyl sulfate, ditallow dipropyl ammonium phosphate, ditallow dimethyl ammonium nitrate, di (coconut alkyl) dimethyl ammonium chloride, di (coconut alkyl) dimethyl ammonium bromide, coconut ammonium chloride, stearamide propyl chloride PG-dimonium phosphate, steal Midopropyl ethyl dimonium esosulphate, stearamide propyl dimethyl (myristyl acetate) ammonium chloride, stearamide propyl dimethyl cetearyl ammonium tosylate, stearamide propyl dimethyl ammonium chloride, stearamide propyl dimethyl ammonium lactate, ethyl lanolin sulfate Fatty acid aminopropylethyldimethylammonium, cationized cellulose, acyldiethylaminoethylamide, acyldimethylaminopropylamide, polyoxyethylene fatty acid amide, myristyldimethylamine oxide, N-lauryldimethylaminoacetic acid betaine, N-myristyldimethylaminoacetic acid betaine, N -Stearyldimethylaminoacetic acid betaine, etc.), bis fatty acid ester salts (hydroxypropyl-bi -Lauric acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-myristic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-palmitic acid amidopropyl-N, N-dimethylammonium chloride, Hydroxypropyl-bis-stearic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-behenic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-oleic acid amidopropyl-N, N- Dimethylammonium chloride, hydroxypropyl-bis-isostearic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl -Bis-palm fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-tallow fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-lauric acid amidoethyl-N, N-diethylammonium chloride , Hydroxypropyl-bis-myristate amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palmitamidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-amidoethyl stearate-N, N-diethylammonium Chloride, hydroxypropyl-bis-behenate amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-oleic acid amidoethylammonium chloride, hydroxypropyl-bis-isostearic acid Midoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-tallow Fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-lauric acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-myristic amidopropyl-N, N-diethylammonium chloride, hydroxypropyl- Bis-palmitic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-stearic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-behenic acid amido Lopyl-N, N-diethylammonium chloride, hydroxypropyl-bis-oleic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-isostearic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis -Palm fatty acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-tallow fatty acid amidopropyl-N, N-diethylammonium chloride, etc. ), Stearamidopropyl PG-dimonium chloride phosphate, behenamidopropyl PG dimonium chloride, stearamidopropylethyl dimonium etosulphate, stearamidopropyldimethyl (myristyl acetate) Cationic surfactants such as ammonium chloride, stearamidepropyldimethylcetearylammonium tosylate, stearamidepropyldimethylammonium chloride, stearamidepropyldimethylammonium lactate, glycerin fatty acid esters (glyceryl monoundecylenate, diundecylenate) Glyceryl, glyceryl monomyristate, glyceryl dimyristate, glyceryl monopalmitate, glyceryl dipalmitate, glyceryl monostearate, glyceryl distearate, glyceryl monooleate, mono cottonseed oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, Glycerol monostearate, α, α'-oleic acid pyroglutamate glycerol, monostearate glycerol malic acid, etc.) Polyglyceryl fatty acid esters (diglyceryl monomyristate, diglyceryl dimyristate, diglyceryl trimyristate, diglyceryl monopalmitate, diglyceryl dipalmitate, diglyceryl tripalmitate, diglyceryl monostearate, distearate distearate Glyceryl, diglyceryl tristearate, diglyceryl monooleate, diglyceryl dioleate, diglyceryl trioleate, tetraglyceryl monopalmitate, tetraglyceryl dipalmitate, tetraglyceryl tripalmitate, tetraglyceryl tetrapalmitate, penta Tetraglyceryl palmitate, tetraglyceryl monostearate, tetraglyceryl distearate, tetraglyceryl tristearate, tetrastearin Tetraglyceryl, tetraglyceryl pentastearate, tetraglyceryl monooleate, tetraglyceryl dioleate, tetraglyceryl trioleate, tetraglyceryl tetraoleate, tetraglyceryl pentaoleate, hexaglyceryl monopalmitate, hexaglyceryl dipalmitate, Hexaglyceryl tripalmitate, hexaglyceryl tetrapalmitate, hexaglyceryl pentapalmitate, hexaglyceryl monostearate, hexaglyceryl distearate, hexaglyceryl tristearate, hexaglyceryl tetrastearate, hexaglyceryl pentastearate, monooleic acid Hexaglyceryl, dioleic acid hexaglyceryl, trioleic acid hexaglyceryl, tetraolei Hexaglyceryl acid, hexaglyceryl pentaoleate, decaglyceryl monopalmitate, decaglyceryl dipalmitate, decaglyceryl tripalmitate,
Decaglyceryl tetrapalmitate, decaglyceryl pentapalmitate, decaglyceryl hexapalmitate, decaglyceryl heptapalmitate, decaglyceryl octapalmitate, decaglyceryl nonapalmitate, decaglyceryl monocaprate, decaglyceryl monostearate, distearic acid Decaglyceryl, decaglyceryl tristearate, decaglyceryl tetrastearate, decaglyceryl pentastearate, decaglyceryl hexastearate, decaglyceryl heptearate, decaglyceryl octastearate, decaglyceryl nonostearate, decaglyceryl decastearate , Decaglyceryl monooleate, decaglyceryl dioleate, decaglyceryl trioleate, tetraoleic acid Kaglyceryl, decaglyceryl pentaoleate, decaglyceryl hexaoleate, decaglyceryl heptaoleate, decaglyceryl octaoleate, decaglyceryl nonaoleate, decaglyceryl decaoleate, decaglyceryl monohydroxystearate, decaglyceryl dihydroxystearate, Decaglyceryl trihydroxystearate, decaglyceryl tetrahydroxystearate, decaglyceryl pentahydroxystearate, decaglyceryl hexahydroxystearate, decaglyceryl heptahydroxystearate, decaglyceryl octahydroxystearate, decaglyceryl nonahydroxystearate, decaglyceryl Decaglyceryl hydroxystearate, hexaglyceryl polyricinoleate, Dericglyceryl ricinoleate, polyoxyethylene glyceryl monostearate, polyoxyethylene glyceryl distearate, polyoxyethylene glyceryl monooleate, polyoxyethylene glyceryl monomyristic acid), polyoxyethylene glyceryl fatty acid ester (polyoxyethylene glyceryl monoester) Stearate, polyoxyethylene glycerol monoisostearate, polyoxyethylene glycerol triisostearate, etc., sorbitan fatty acid ester (sorbitan monolaurate, sorbitan monooleate, sorbitan sesquioleate, sorbitan trioleate, sorbitan monopalmitate) Sorbitan monostearate, sorbitan distearate, sorbitan dioleate, sol monopalmitate Vitan, sorbitan tristearate, sorbitan trioleate, diglycerin sorbitan penta-2-ethylhexylate, diglycerin sorbitan tetra-2-ethylhexylate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, monopalmitin Polyoxyethylene sorbitan acid, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan trioleate, polyoxyethylene sorbitan pentaoleate, propylene glycol fatty acid ester (propylene glycol monooctanoate, propylene glycol monodecanoate, monostearic acid) Propylene glycol, etc.), sucrose fatty acid ester (monolauric acid sucrose ester, dilauric acid sucrose ester, monopara Sucrose ester of mitotic acid, sucrose ester of dipalmitate, sucrose monostearate, sucrose ester of distearate, dextrin fatty acid ester (dextrin palmitate, etc.), coconut oil fatty acid alkanolamide, polyoxyethylene castor oil, Polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, polyoxyethylene hydrogenated castor oil malee Acid, polyoxyethylene alkyl ether (alkyl polyglucoside, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene behenyl ether Polyoxyethylene oleyl ether, polyoxyethylene lauryl ether, polyoxyethylene-2-octyldodecyl ether, polyoxyethylene cholestanol ether, etc.), polyoxyethylene alkylphenyl ether (polyoxyethylene nonylphenyl ether, polyoxyethylene octylphenyl) Ethers, etc.), polyoxyethylene fatty acid esters (polyethylene glycol monooleate, polyethylene glycol monostearate, polyethylene glycol monolaurate, etc.), lanolin derivatives (polyoxyethylene lanolin, polyoxyethylene lanolin alcohol, polyoxyethylene sorbitol lanolin, etc.) , POE • POP-alkyl ether (POE • POP-cetyl ether, POE • POP-2-decyltetradecyl ether, POE • P Non-ionic such as OP-monobutyl ether, POE / POP-hydrogenated lanolin, POE / POP-glycerin ether, Tetronic, etc.), alkanolamides (coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.) Surfactant, betaine-type amphoteric surfactant (2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, undecylcarboxymethoxyethylcarboxymethylimidazolinium betaine sodium, undecyl Hydroxyethylimidazolinium betaine sodium, undecyl-N-hydroxyethyl-N-carboxymethylimidazolinium betaine, alkyldiaminoethylglycine hydrochloride, stearyl dihydroxyethyl betaine, steari Dimethylaminoacetic acid betaine, stearyldimethylbetaine sodium solution, coconut oil alkyl-N-carboxyethyl-N-hydroxyethyl imidazolinium betaine sodium, coconut oil alkylbetaine, coconut oil alkyldimethylaminoacetic acid betaine, coconut oil fatty acid amidopropyl betaine , Palm oil fatty acid-N-carboxymethoxyethyl-N-carboxyethylimidazolinium betaine sodium, N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, N-cocoyl-N'-carboxymethyl-N '-Hydroxyethylethylenediamine sodium, lauryldimethylaminoacetic acid hydroxysulfobetaine, coconut oil alkyldimethylaminoacetic acid hydroxysulfobetaine, laurylaminopropionic acid triethanolamine, β-lauric acid Sodium ruaminopropionate, amidopropyl dimethylaminoacetic acid betaine laurate, amidopropyl dimethylaminoacetic acid hydroxysulfobetaine laurate, coconut oil fatty acid amidopropyldimethylaminoacetic acid hydroxysulfobetaine, palm oil fatty acid amidopropyldimethylaminoacetic acid hydroxysulfobetaine, Palm oil fatty acid amidopropyldimethylaminoacetic acid betaine, palm oil fatty acid amidopropyldimethylaminoacetic acid betaine, lauryl-N-carboxymethoxyethyl-N-carboxymethylimidazolinium disodium dodecanoyl sarcosine, lauryldiaminoethylglycine sodium, lauric acid amide Propyl betaine solution, lauryl sulfobetaine, lauryl hydroxysulfobetaine, 2-heptadecyl-N-carbo Cymethyl-N-hydroxyethylimidazolinium betaine, cocodimethylcarboxymethylbetaine, lauryldimethylcarboxymethylbetaine, lauryldimethylalphacarboxyethylbetaine, cetyldimethylcarboxymethylbetaine, cetyldimethylbetaine, laurylbis- (2-hydroxyethyl) carboxymethyl Betaine, stearylbis- (2-hydroxypropyl) carboxymethylbetaine, oleyldimethylgamma-carboxypropylbetaine, laurylbis- (2-hydroxypropyl) alpha-carboxyethylbetaine, cocodimethylsulfopropylbetaine, stearyldimethylsulfopropylbetaine, lauryl Dimethylsulfoethylbetaine, laurylbis- (2-hydroxyethyl) sulfopropylbeta , Levon 2000 (Sanyo Kasei Co., Ltd.), coconut oil fatty acid amidopropyldimethylbetaine, coconut oil fatty acid amidopropylsulfobetaine, imidazolinium type amphoteric surfactant (bis (stearyl-N-hydroxyethylimidazoline) chloroacetic acid complex, N -Alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-alkyl-N-carboxymethyl-N-hydroxyethylethylenediamine laurylsulfuric acid and its salts, coconut oil alkyl-N-carboxyethoxyethyl-N- Carboxyethyl imidazolinium disodium hydroxide, coconut oil alkyl-N-carboxymethoxyethyl-N-carboxyethyl imidazolinium disodium hydroxide, coconut oil alkyl-N-carboxymethoxyethyl-N-carboxyethyl imidazolinium di Sodium Lauri Sulfuric acid, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, ovazoline 662 (Toho Chemical) ), Swanol AM-101 (Nikko Chemicals), etc., aminopropionic acid type amphoteric surfactants (alkylaminopropionic acid such as sodium dodecylaminopropionate, alkylaminodipropionic acid, etc.), sodium dodecylaminopropanesulfonate, N-higher alkyl aspartic acid or salts thereof, coamidopropyl chlorinated polyethylene glycol dimonium phosphate, cocamidopropyl hydroxysultain, sodium lauroyl sarcosinate, alkylamine oxide (decylamine oxide, cocoamine oxide, myristoyl Amphoteric surfactants such as sulfoxide, palmitoylamine oxide, alkyldimethylamine oxide, alkylamidopropylamine oxide), natural surfactants (lecithin, sodium caseinate, sphingolipids, saponins, mannosyl polyhydric alcohol fatty acid esters, glucosyl many Monohydric polyhydric alcohol fatty acid esters such as monohydric alcohol fatty acid esters and galactosyl polyhydric alcohol fatty acid esters, disaccharide polyhydric alcohol fatty acid esters, oligosaccharide polyhydric alcohol fatty acid esters, etc.) and amino acid surfactants (capric acid chloride, laurin) Fatty acid chlora such as acid chloride, myristic acid chloride, palmitic acid chloride, stearic acid chloride, oleic acid chloride, behenic acid chloride, coconut oil fatty acid chloride And glycine, sarcosine, β-alanine, N-methyl-β-alanine, taurine, N-methyltaurine and other wide-ranging amino acids), silicone surfactants (silicon KF-6011 (Shin-Etsu Chemical Co., Ltd.) KF-6012 (Shin-Etsu Chemical Co., Ltd.), KF-6013 (Shin-Etsu Chemical Co., Ltd.), KF-6015 (Shin-Etsu Chemical Co., Ltd.), KF-6016 (Shin-Etsu Chemical Co., Ltd.), KF-6017 (Manufactured by Shin-Etsu Chemical Co., Ltd.), X-22-4991 (manufactured by Shin-Etsu Chemical Co., Ltd.), NUC silicon L7002 (manufactured by Nihon Unicar), SH-3772C (manufactured by Toray Dow Corning Silicone), SH-3775C (manufactured by Toray Dow Corning) Polyoxyalkylene-modified organopolysiloxanes such as Silicone), ABIL EM-90 (Gold Schmidt), ABIL B9806 (Gold Schmidt), Silicon KF-6026 (Shin-Etsu Chemical) Alkyl-containing polyoxyalkylene-modified organopo Siloxane, etc.), polyether-modified silicone (polyoxyethylene / methylpolysiloxane copolymer, poly (oxyethylene / oxypropylene) methylpolysiloxane copolymer, etc.), oxazoline-modified organopolysiloxane, alkyl-modified organopolysiloxane, styryl Ketone silicone derivatives, dimethylpolysiloxane, methylphenylpolysiloxane, epoxy modified silicone, fluorine modified silicone, alcohol modified silicone, alkyl modified silicone, alkoxy modified silicone, amino modified silicone, ammonium modified polymer silicone, organopolysiloxane, methylphenyl poly Siloxane, polysiloxane, poly (N-acylalkylenimine) modified silicone, dimethylpolysiloxane, nitrogen Le - silicone graft copolymer, decamethylcyclopentasiloxane, fluorinated alkyl-modified silicone, organopolysiloxane siloxanyl silyl al
Kill modified silicone, tricyclic diterpene carboxylic acid modified silicone, trifluoroalkyl modified silicone, divinyl polydimethylsiloxane, dihydrogen polydimethylsiloxane, dihydrogen polydimethylsiloxane divinyl polydimethylsiloxane polymer, trimethylsiloxysilicic acid, polyoxy Propylene / methylpolysiloxane copolymer, ethylpolysiloxane, ethylmethylpolysiloxane, ethylphenylpolysiloxane, octamethylcyclotetrasiloxane, diorganopolysiloxane, octamethylcyclotetrasiloxane, tetramethyltetraphenyltetracyclosiloxane, polyester Tell-modified polysiloxane, amino-modified polysiloxane, epoxy-modified polysiloxane, fluorine-modified polysiloxane, alcohol Functional polysiloxane, alkyl-modified polysiloxane, dodecamethylcyclohexasiloxane, laurylmethicone copolyol, aminoethylaminopropylsiloxane / dimethylsiloxane copolymer, silicone compounds such as eugenol-modified silicone, selenium disulfide, alkylisoquinolyl bromide Examples thereof include hair treatment agents such as nium solution, zinc pyrithione, biphenamine, thianthol, quinine hydrochloride, and strong aqueous ammonia.

  Others, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, refreshing agents, stabilizers, emulsifiers, animal / plant proteins and their degradation products, animal / plant polysaccharides and their Degradation products, animal / plant glycoproteins and their degradation products, anti-inflammatory agents, antiallergic agents, wound treatment agents, foaming agents, thickeners, enzymes, purified water (electronic water, small clusters, etc.), deodorant / A deodorant etc. can be used in combination.

  Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

(Test 1) Caspase-14 expression inducing action test The present inventor evaluated the protein expression level in caspase-14 using the Western Blotting method.
"Test method and evaluation method"
Normal human epidermal keratinocytes (manufactured by Kurashiki Boseki Co., Ltd.) were cultured until confluent, further cultured for 48 hours, and then synephrine of the present invention was added as a sample and cultured for 20 hours. Thereafter, the protein was extracted with Lysis Buffer (including Complete mini). The extracted protein was subjected to quantitative analysis, heat-treated at 95 ° C., and subjected to SDS-PAGE and Western blotting at 1 μg / well. Anti-Caspase14 antibody (Santa Cruz) is used as the primary antibody, HRP-labeled Anti-IgG (GE) is used as the secondary antibody, light is emitted by ECL, and detection and quantitative analysis is performed using ChemiDoc (Bio-Rad). went. In addition, the caspase-14 expression level of each sample with respect to the case where the control caspase-14 expression level was 100 was digitized, and the results are shown in FIG.
"sample"
Samples for the caspase-14 expression inducing action test were subjected to the test by adding 10 μM or 20 μ of synephrine of the present invention (manufactured by Sigma Aldrich Japan LLC). As a control, a solution dissolved in a 70% 1,3-butylene glycol aqueous solution was prepared under the same conditions and used in the test.

(Test results)
The results are as shown in FIG. 1. Compared with the control 70% 1,3-butylene glycol aqueous solution, the synephrine of the present invention has a strong effect of inducing the expression of caspase-14, and the addition of synephrine 20 μM more than doubles. It was confirmed that it has an effect of inducing the expression of caspase-14.

(Formulation Example 1) Milk Mass%
1. Squalane 8.0
2. Jojoba oil 7.0
3.Cetyl alcohol 2.0
4.Glycerin monostearate 2.0
5. Polyoxyethylene (20) cetyl ether 3.0
6.1,3-Butylene glycol 1.0
7.Glycerin 1.0
8. Synephrine of the present invention 0.1
9. Preservative (methyl paraoxybenzoate) appropriate amount
10. Residue with 100 purified water

(Formulation example 2) Essence liquid mass%
1. Sarah Beeswax 11.0
2.liquid paraffin 22.0
3.Lanoline 10.0
4.Olive oil 5.0
5. Palm oil 5.0
6. Synephrine of the present invention 0.1
7. Okra fruit 50% glycerin extract 1.0
8. Bilberry leaf 50% 1,3-ethanol extract 1.0
9.Liquid shea fat 1.0
10.Dipotassium glycyrrhizinate 0.1
11. Perfume (lavender water) appropriate amount
12.Residue with 100 purified water

(Formulation example 3) Moisturizing cream mass%
1.Squalane 10.0
2.liquid paraffin 10.0
3.Stearic acid 2.0
3.Cetanol 3.0
4.Dimethylpolysiloxane 1.0
5.Cholesterol 0.5
6. Vaseline 2.0
7.Dipropylene glycol 3.0
8.Glycerol monostearate2.0
9. Shirabirame collagen 1.0
10.Synephrine of the present invention 0.1
11. Preservative (Isopropylmethylphenol) appropriate amount
12.Residue with 100 purified water

(Formulation example 4) Pack mass%
1.Polyvinyl alcohol 15.0
2.Carboxymethylcellulose sodium 5.0
3.Propylene glycol 3.0
4.Ethanol 10.0
5. Synephrine of the present invention 0.1
6. 鯛 Collagen 1.0
7. Antibacterial and antiseptic (polylysine) appropriate amount
8. Fragrance (rose water) appropriate amount
9. Residue with 100 purified water

  The present invention relates to a caspase-14 expression inducer containing a phenylethylamine derivative or synephrine as an active ingredient, a skin external preparation containing a caspase-14 expression inducer, and the phenylethylamine derivative or synephrine of the present invention is a caspase- It can be provided as a moisturizing agent, wetting agent or the like because of its 14 expression-inducing action.

Claims (1)

  A caspase-14 expression inducer containing synephrine as an active ingredient.

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