JP2006327988A - Whitening agent and skin care preparation for whitening - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To develop a new whitening agent having high effectiveness and to provide applications thereof, that is, to provide the whitening agent exhibiting high effects by using nimbin having excellent whitening actions, for further detail, inhibitory actions on melanin formation, and to provide whitening effects such as effective inhibition and amelioration of pigmentation of the skin such as stains, freckles, dullness or skin blackening caused by ultraviolet exposure by applying the whitening agent to a skin care preparation for whitening. <P>SOLUTION: The whitening agent and the skin care preparation for whitening comprise nimbin as an active ingredient. The method for whitening the skin comprises applying the composition comprising the nimbin as the active ingredient to the skin. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a novel and safe whitening agent, a skin whitening external preparation, and a whitening method for applying the same to the skin.

  Factors that determine human skin color include the amount of melanin in the epidermis, capillary blood flow, food-derived pigments, and stratum corneum thickness. Among these, one of the most important factors There are melanin pigments. The so-called spots (liver spots), buckwheat (sparrow egg spots), dullness, and skin pigmentation after sunburn are markedly enhanced production of melanin pigments due to the activation of pigment cells present in the skin. Whitening agents are used in the cosmetics industry to prevent or improve pigmentation such as spots, freckles, dullness, and skin blackening after sunburn, which is one of the major skin problems for age groups and women. Has been.

  This melanin pigment is generated in melanosomes, which are organelles in pigment cells (melanocytes) present in the basal layer of the epidermis, the hair root, and the outer root sheath. In the melanin pigment formation process, tyrosinase acts on tyrosine in the pigment cell, tyrosine is oxidized, converted to dopa and dopaquinone, further auto-oxidized, polymerized via dopachrome and 5,6-dihydroxyindole, and finally polymerized. It becomes a melanin pigment. The melanin produced is secreted into the basal cells from the dendrites of the pigment cells, and when the basal cells divide and become spiny cells, it rises, reaches the stratum corneum, and then falls off with the exfoliation of the stratum corneum It is considered.

Based on the above biological reaction process, items to be studied in developing a whitening agent include (1) the property of suppressing the activity of tyrosinase involved in the production of melanin pigment, and (2) the production of melanin pigment. (3) In order to promote melanin excretion based on the promotion of turnover, the ability to activate cell division of basal cells can be exemplified. As a substance having these properties, ascorbine Examples include acids or derivatives thereof, arbutin, plant extracts, microbial cell extracts, fermentation products, and the like (Non-patent Document 1). In recent years, the process of proliferation or activation of pigment cells themselves and the process of expression and activation of tyrosinase itself has been actively studied, and various factors have been discovered and substances that affect these factors have been developed. (Non-patent document 2, Patent document 1, Patent document 2). However, various whitening agents have been developed so far, but there is a strong demand for new development of whitening agents with higher effectiveness.
FRAGRANCE JOURNAL Special issue, No.14, 1995, 118-126 FRAGRANCE JOURNAL Special issue, No.18, 2003, 9-15, 22-29, 42-49, 50-55 JP 2003-183175 A JP 2003-194809 A

  Therefore, the problem to be solved is the development and application of a new whitening agent having high effectiveness.

As a result of development in view of such circumstances, the present inventor found that ninbin has an excellent whitening effect and has completed the present invention. Nimbin has been conventionally used as a termite control agent (for example, see Patent Document 1), an animal repellent (for example, see Patent Document 2), an insecticide (for example, see Patent Document 3), etc. No whitening effect has been found yet.
Japanese Patent Laid-Open No. 05-286816 Japanese Patent Laid-Open No. 08-239306 JP 09-255684 A

  More specifically, it was confirmed that nimbin has an excellent melanin production inhibitory effect, and a whitening agent containing this as an active ingredient has been provided.

  Moreover, this invention provides the skin external preparation for whitening which mix | blends the said whitening agent.

  In addition, according to the present invention, it is possible to provide a skin whitening method characterized by applying a composition containing nimbin as an active ingredient to the skin.

  Ninbin, which is an active ingredient of the product of the present invention, has an excellent whitening action, specifically, a melanin production inhibitory action. By using this compound, it is possible to constitute a whitening agent that exhibits a high effect. . By applying this to a skin whitening preparation for whitening, it becomes possible to provide a whitening effect such as effective suppression and improvement of skin pigmentation such as skin darkening, freckles, dullness or skin blackening caused by UV exposure. It was. Furthermore, the whitening agent, the whitening skin external preparation and the skin whitening method of the present invention are very safe for the human body, such as cosmetic compositions, pharmaceuticals, quasi-drugs, foods and drinks, etc. It can be used in a wide range in the field.

  Nimbin, which is an active ingredient of the present invention, is a compound represented by the following formula. In addition, optical isomers based on all asymmetric carbons generated in the structure of the following compounds or their racemates are also included in the scope of the present invention.

分子量：540.609
IUPAC名：(17α)-6α-アセトキシ-7α,15β:21,23-ジエポキシ-4β,8-ジメチル-1-オキソ-18,24-ジノル-11,12-セコ-5α-コラ-2,13,20,22-テトラエン-4α,11-ジカルボン酸ジメチルエステル（(17α)-6α-Acetoxy-7α,15β:21,23-diepoxy-４β,8-dimethyl-1-oxo-18,24-dinor-11,12-seco-5α-chola-2,13,20,22-tetrene-4α,11-dicarboxylic acid dimethyl ester）

Molecular weight: 540.609
IUPAC name: (17α) -6α-acetoxy-7α, 15β: 21,23-diepoxy-4β, 8-dimethyl-1-oxo-18,24-dinol-11,12-seco-5α-cola-2,13 , 20,22-Tetraene-4α, 11-dicarboxylic acid dimethyl ester ((17α) -6α-Acetoxy-7α, 15β: 21,23-diepoxy-4β, 8-dimethyl-1-oxo-18,24-dinor- 11,12-seco-5α-chola-2,13,20,22-tetrene-4α, 11-dicarboxylic acid dimethyl ester)

  As ninbin in the present invention, a pharmacologically acceptable salt can also be used in the present invention, and examples thereof include a salt with an inorganic base or a salt with an organic base. Specific examples of the salt with an inorganic base include sodium salt, potassium salt, calcium salt, magnesium salt, barium salt, lithium salt, aluminum salt, copper salt, zinc salt, iron salt and the like. Examples of the salt with an organic base include ammonium salt, trimethylamine salt, triethylamine salt, pyridine salt, picoline salt, ethanolamine salt, diethanolamine salt, triethanolamine salt, dichloroamineamine salt, and dibenzylethylenediamine salt. In addition, the compound includes both anhydrides and hydrates within the scope of the present invention.

  Although the said compound can also be manufactured by a well-known chemical synthesis method, the manufacturing method by extraction from the natural product containing the said compound and isolation | separation purification is mentioned. Moreover, what is generally marketed can also be used.

  The natural products containing nimbin include Meliaceae neem (Melia azadirachta L. (= Azadirachta indica Juss.) (Also known as Indian Sendang, Margosa)), Sendang (M. azedarach L.), Tosen (M. plants such as toosendan Sieb.et Zucc.).

  The use site of the plant used in the present invention is preferably a seed, but in addition, one kind selected from flowers, flower spikes, flower buds, flower buds, stems, leaves, branches, branches and leaves, rhizomes, root barks, roots, seeds, etc. Or 2 or more types can be used.

  The extraction method is not particularly limited as long as it does not contradict the object of the present invention. For example, neem seeds are degreased with hexane, kerosene, etc., and then the residue is extracted again with a hydrophilic extraction solvent. The obtained extract can be purified by column chromatography or the like as it is, but preferably further fractionation treatment is performed. Examples of the solvent used for fractionation include aqueous methylene chloride.

  Examples of the hydrophilic extraction solvent include one kind selected from alcohols such as methanol, ethanol, 2-propanol, 1,3-butylene glycol, and glycerin, water, and the like, or a mixed solvent thereof.

  Regarding the extraction method, the temperature and pressure of the solvent, the weight ratio of the solvent to the raw material, and the extraction time can be arbitrarily set for various raw materials and the solvent used. Moreover, in performing extraction operation, the plant raw material to be used performs operations, such as cutting, crushing, pressing, and homogenizing, as necessary.

  For the purpose of improving the recovery rate of nimbin or its salt, after performing the above extraction operation, filtration using filter paper, filter aid, membrane filter, etc., centrifugation, concentration under reduced pressure, pH adjustment, salting out, etc. Operations can be performed as appropriate.

  In producing a compound from a plant, after performing the extraction operation, a separation and purification operation is further performed as an essential operation. Separation and purification operations may be appropriately combined with usual separation and purification means such as a separation operation method, distillation method, sublimation method, precipitation method, recrystallization method, filtration using a filter aid or resin, or column chromatography method. Do.

  Furthermore, for the purpose of removing impurities during the separation and purification operation, it is possible to perform an appropriate decomposition operation of the impurities components.

  In preparing a whitening agent using nimbin which is an active ingredient of the present invention, it is possible to use the fine powder or fine crystalline compound as it is as a whitening agent, as well as water or an organic solvent or its appropriate It is also possible to use it as an antioxidant by dissolving or dispersing in a liquid mixture and adjusting it into a liquid or pellet form. Furthermore, it can be mixed with an excipient, a thickener, a gelling agent, etc., and adjusted to a granular shape, a gel shape, or a viscous liquid and used as a whitening agent.

  The dosage form of the whitening agent of the present invention is arbitrary, ampoules, capsules, powders, granules, pills, tablets, solids, liquids, gels, bubbles, emulsions, creams, ointments , Sheet-like, mousse-like, powder-dispersed, multilayer, aerosol-like pharmaceuticals, quasi-drugs, and cosmetics.

  Furthermore, a skin external preparation can be constituted using the whitening agent of the present invention, and in particular, a skin external preparation for whitening can be constituted. Specific use forms include basic cosmetics such as lotions, emulsions, creams, ointments, lotions, oils, packs, etc., skin cleansing agents such as soaps, cleansing creams, cleansing lotions, facial cleansers, shampoos, rinses, treatments, etc. Hair-washing cosmetics, hair creams, hair sprays, hair tonics, hair gels, hair lotions, hair oils, hair essences, hair waters, hair waxes, hair foams, hair straighteners, hair restorations, hair nourishing agents, 1-component hair dyes And two-component hair dyes, hair dyes such as hair colors, permanent cosmetics such as permanent wave agents and hair straighteners, and hair cosmetics such as wave retention agents, foundations, white powder, white lipsticks, lipsticks, blushers, eye shadows, Makeup cosmetics such as eyeliner, mascara, eyebrows, eyelashes, and cosmetics for finishing such as beauty nails Cosmetic compositions such as oral compositions such as water, toothpastes, gargles, etc., pharmaceutical preparations for external use, ointments, haptics, bath preparations, medicated toothpastes, medicinal oral compositions such as mouth fresheners, medicinal cosmetics, Permanent wave solvents, hair dyes, hair growth agents, hair loss prevention agents, hair solvent odors and deodorants such as hair removal agents, hygiene products, hygiene cotton, quasi-drugs such as wet tissue, and external medicines Can be mentioned.

  Moreover, in this invention, the skin whitening method characterized by applying the said composition which uses nimbin as an active ingredient to skin can be provided.

  The blending amount of the ninbin, which is the active ingredient of the present invention, differs slightly depending on the type, quality, and expected level of the whitening agent and the external preparation for skin, but is not particularly limited, but is usually 0.0001% by mass or more in the total amount of the formulation. It is generally used in the concentration range (hereinafter expressed as%), preferably 0.01 to 20.0% is effective.

  The whitening agent and the skin external preparation for whitening of the present invention include, in addition to the essential component ninbin, a pigmentation inhibitor, a tyrosinase activity inhibitor, a melanocyte melanin production inhibitor, a melanin production promoter, and a moisturizer as exemplified below. , Cell activator / metabolic activator, antioxidant, active oxygen scavenger / radical production inhibitor, fat metabolism promoter, UV protection agent / UV absorption promoter, astringent, anti-inflammatory agent / interleukin production inhibitor / Antiinflammatory agent, Antiseborrheic agent, Antibacterial agent / Antiviral agent, Blood flow promoter / Vessel stimulant, Antiandrogen agent, Structural proteolytic enzyme (elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degradation Enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme Etc.) Activity inhibitors, structural protein synthesis promoters, mucopolysaccharides (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitors, mucopolysaccharide synthesis promoters, intercellular adipogenesis promoter / intercellular lipid state improving agent, keratin Solubilizer / stratum corneum peeling promoter, plasminogen activator antagonist inhibitor, Maillard reaction inhibitor, testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promoter, hair matrix growth inhibitor / hair growth Active ingredients such as inhibitors, hair swelling / protecting agents, odorant elimination agents, and other plant-based and animal-based ingredients that are preferred for use in the form of cosmetic compositions and food compositions It is possible to select and use various components as additives, such as extracts and metabolites derived from microbial raw materials, other natural product raw materials, etc. A cosmetic composition or food composition can be provided. The content in the preparation is not particularly defined, but usually a concentration range of 0.0001 to 50% is common.

(1) Pigmentation inhibitor Specifically, p-aminobenzoic acid derivatives, salicylic acid derivatives, benzenesulfonamide derivatives, imidazole derivatives, naphthalene derivatives, hydroxyanthranilic acid or salts thereof and derivatives thereof, anthranilic acid derivatives, coumarins Derivatives, amino acid derivatives (2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid, 2-amino-3- [1-carboxyl-2- (1H- Imidazol-4-yl) ethyl] aminobutanoic acid hydrochloride, 2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid sodium salt, 2-amino- 3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid potassium salt, etc.), benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, geo Xanthane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, ascorbic acid or salts thereof and derivatives thereof (phosphate-L-ascorbic acid magnesium, ascorbyl palmitate, ascorbyl dipalmitate, Ascorbic acid hydroxyproline phosphate, 5-o-α-D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate Magnesium salt, L-ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate mag Cium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid sulfate aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L -Aluminum ascorbate, 6-o-α-D-galactopyranosyl-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, magnesium L-ascorbate phosphate Salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o -Acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl-L-ascorbic acid, 6-o-alkyl Ascorbic acid phosphate potassium salt, 6-o-alkyl ascorbic acid phosphate calcium salt, 6-o-alkyl ascorbic acid phosphate barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o -Alkylascorbic acid phosphate monoethanolamine salt, 6-o-alkylascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate ester Monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o- β-D-galactopyranosyl-L-ascorbic acid, as Rubinic acid phosphate cholesterol ester, palmitic acid-L-ascorbyl, isopalmitic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L -Ascorbyl, distearic acid-L-ascorbyl, diisostearic acid-L-ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2 -Ethylhexanoic acid-L-ascorbyl, di-2-ethylhexanoic acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α- D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl - L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitate, L-ascorbic acid tetralaurate, L-2-ascorbic acid tetra-2-ethyl Hexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o- Ethyl ascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate , 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl] -4'-ace Xifellate, DL-α-tocopherol-2-L-ascorbic acid diester, ascorbic acid inositol-conjugated derivative, ascorbic acid phosphoramide derivative, ascorbic acid arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic Acid derivatives, etc.), tocopherols or salts thereof and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, Tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside Sid, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl Maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-toco Ferryl maltoside, 1- Rufoethylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol, 1- (carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol Hydrochloride, S- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl]- γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-iroxy) -2 -Hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol Russuccinate, tocotrienol linoleate, tocotrienol orotate, etc.), kojic acid or derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-Benzolyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran -4-one, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate , Kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.), oxybenzone, benzophenone, gua Iazulene, shikonin, baicalin or salts thereof and derivatives thereof, baicalein or salts thereof and derivatives thereof, berberine or salts thereof and derivatives thereof, chrysin or salts thereof and derivatives thereof, apigenin or salts thereof and derivatives thereof, luteolin Or salts thereof and derivatives thereof, acacetin or salts thereof and derivatives thereof, diosmethine or salts thereof and derivatives thereof, kaempferol or salts thereof and derivatives thereof, triphorin or salts thereof and derivatives thereof, astragalin or salts thereof And derivatives thereof, quercetin or salts thereof and derivatives thereof, quercitrin or salts thereof and derivatives thereof, isoquercitrin or salts thereof and derivatives thereof, rutin or salts thereof and derivatives thereof. Body, morin or a salt thereof and derivatives thereof, myricetin or a salt thereof and derivatives thereof, myricitrin or a salt thereof and derivatives thereof, datiscetin or a salt thereof and derivatives thereof, quercetagetin or a salt thereof and derivatives thereof, isorhamnetin or Salts thereof and derivatives thereof, pinocembrin or salts thereof and derivatives thereof, naringenin or salts thereof and derivatives thereof, hesperetin or salts thereof and derivatives thereof, eriodictyol or salts thereof and derivatives thereof, pinobankin or salts thereof and Derivatives thereof, aromadendrin or a salt thereof and derivatives thereof, engelitin or a salt thereof and derivatives thereof, taxofolin or a salt thereof and derivatives thereof, astilbine or a salt thereof and the same Derivatives, amperopsin or salts thereof and derivatives thereof, spiraeoside, kaempferol-7-neohesperidoside, glutathione or salts thereof and derivatives thereof, isoflavone glycosides (6-o-apiosylpuerarin-4'-o -Glucosides, 6-o-glucosyl puerarin, 3'-hydroxy puerarin-4'-o-glucoside, 6-o-apiosyl-3'-hydroxy puerarin), γ-pyrone glycosides (maltol-3-o-) (6'-o-apiosyl) -glucoside, maltol-3-o- (6'-o-apiosyl) -glucoside, etc.), isononyl ferrate, ellagic acid or salts thereof and derivatives thereof (5,4-dimethyl) Ellagic acid, 3,3'-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-methoxyellagic acid, 3-ethyl-4-methyl- 5-hydroxy ellagic acid, amritoside, etc.), lucinol, ON Saponin, Bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin, senegin, benzoic acid anilides (4-hydroxy-N- (2-hydroxyphenyl) benzoic acid amide, 4-hydroxy-N- (3-hydroxyphenyl) ) Benzamide, 4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl -4-hydroxy-N- (3-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N- (2-hydroxyphenyl) benzamide, etc.), diphenylpyralin, cyproheptadine, triprolidine, dimethindene , Ozagrel, istipendil, iproheptin, homochlorcyclidine, alimemazine, bucillamine, oxytosamide, vidarabine, xanthotoxin Sole, phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide, placenta (bovine origin, pig origin, horse origin, sheep origin, etc.) extract, almond extract Ammarok Extract, Oyster Extract, Ovana Okella Extract, Ochera Extract, Konfuyo Extract, Uncaria Extract, Gaijicha Extract, Gypsophila Extract, Licorice Extract, Gardenia Extract, Kranigean Extract, Clara Extract, Koganebana (Ogon) ) Extract, wheat (wheat) extract, rice (rice) extract, Koreaia extract, Sidwaya extract, sun cucumber extract, sanvitro extract, sun pens extract, silane (bikkyu) extract, senkyu (river cucumber) extract, senna extract, sempukuka extract , Senkutsusai extract, Su Rigatin extract, Nodake (mae-hu) extract, pearl barley (yokuinin) extract, hamago extract, honey beetle extract, hamamelis extract, palm extract, parietalia extract, safflower (safflower) extract, mugwa (mulberry bark) ) Extract, malvanojadin (bitter gins) extract, purple squirrel extract, white squirrels extract, mugwort mugwort extract, yashajitsu extract, hongkong extract, bituminous (ground) extract, quail lily extract, scallop extract, scorpion extract and the like.

(2) Tyrosinase activity inhibitors Specifically, ascorbic acid or a salt thereof and derivatives thereof (phosphate-L-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyprophosphate phosphate ascorbate, 5- o-α-D-Glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate Calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L -Ascorbic acid sulfate Stell aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyrano Sil-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Ester sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl- L-ascorbic acid, 6-o-alkylascorbic acid phosphate potassium salt, 6-o-alkylascorbic acid phosphate Steal calcium salt, 6-o-alkyl ascorbic acid phosphate barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o-alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl Ascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanol Amine salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, phosphorus ascorbate Acid cholesterol ester, palmitic acid-L-ascorbyl, isopa Mycinic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid-L-ascorbyl, diisostearic acid-L- Ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid-L-ascorbyl, di-2-ethylhexane Acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α- D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-malto Triosyl-L-ascorbic acid, L-ascorbic acid Trisopalmitic acid ester, L-ascorbic acid tetralauric acid ester, L-ascorbic acid tetra-2-ethylhexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, L- Ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbyl triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl cinnamate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphoric acid diester, Scorbic acid inositol-linked derivatives, ascorbic acid phosphoramide derivatives, ascorbic acid arbutin conjugates, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivatives, ascorbic acid sialic acid derivatives, etc.), hydroquinone or its salts and their derivatives (hydroquinone α-D-glucose) , Hydroquinone β-D-glucose, hydroquinone α-L-glucose, hydroquinone β-L-glucose, hydroquinone α-D-galactose, hydroquinone β-D-galactose, hydroquinone α-L-galactose, hydroquinone β-L-galactose, etc. Hexoses, hydroquinone α-D-ribose, hydroquinone β-D-ribose, hydroquinone α-L-ribose, hydroquinone β-L-ribose, hydroquinone α-D-arabinose, hydroquinone β-D -Five carbon sugar glycosides such as arabinose, hydroquinone α-L-arabinose, hydroquinone β-L-arabinose, hydroquinone α-D-glucosamine, hydroquinone β-D-glucosamine, hydroquinone α-L-glucosamine, hydroquinone β-L -Amino sugar glycosides such as glucosamine, hydroquinone α-D-galactosamine, hydroquinone β-D-galactosamine, hydroquinone α-L-galactosamine, hydroquinone β-L-galactosamine, hydroquinone α-D-glucuronic acid, hydroquinone β-D -Glucuronic acid, hydroquinone α-L-glucuronic acid, hydroquinone β-L-glucuronic acid, hydroquinone α-D-galacturonic acid, hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, hydroquinone β-L-galacturon Hydroquinone glycosides such as uronic acid glycosides such as acids Body, hydroquinone benzyl ether, 4-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) butane, 5-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) pentane, 6-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) hexane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propane, 2-β-D- Hydroquinone hydroxyalkyl ether glycosides such as glucopyranosyloxy-1- (4-hydroxyphenoxy) butane and 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propan-3-ol ), Kojic acid or a salt thereof and derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoluyloxy Methyl-5-hydroxy-4H-pyran-4-one, 2-cinna Iroxymethyl-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate , Kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.), tocopherol or salts thereof and derivatives thereof (Α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol Errol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside Sid, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl Maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocov Lyl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, L- (sulfoethylamino) -3- (α-tocopheryl-6-iroxy) Propan-2-ol, 1- (carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy ) -2-Hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl) -6-Iroxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α -Tocotrienol, β-Tocotrienol, γ-Toco Lienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate), N-acetyltyrosine or a salt thereof and derivatives thereof, glutathione or a salt thereof and derivatives thereof, ellagic acid Or a salt thereof and a derivative thereof (3,4-dimethylellagic acid, 3,3′-dimethylellagic acid, 3,3 ′, 4-trimethylellagic acid, 3,3 ′, 4,4′-tetramethyl-5 -Methoxyellagic acid, 3-ethyl-4-methyl-5-hydroxyellagic acid, amritoside, etc.), isonitrine A, isonitrine B, isonitrine C, isonitrine D, isonitrinic acid E, isonitrinic acid F, dermadein, tricobylidein, etc. Isonitrile antibiotics, orselinic acid derivatives (orceric acid, Ruthenic acid ethyl ester orcinol, p-geranylorceric acid, p-geranylorceric acid ethyl ester geranylorcinol, p-farnesylorselinic acid, p-farnesylorselinic acid ethylester farnesylorcinol, p-dodecanylol Serine acid, p-dodecanylorceric acid ethyl ester dodecanylorcinol, p-tetradecanylorceric acid, p-tetradecanylorceric acid ethylester tetradecanylorcinol, p-hexadecanylorceric acid P-hexadecanylorceric acid ethyl ester hexadecanylorcinol, p-undecanylorceric acid, p-undecanylorceric acid ethylester undecanylorcinol, p-tridecanylorceric acid, p-Tridecanylorceric acid ethyl ester undecanyl Orcinol, p-pentadecanylorceric acid, p-pentadecanylorceric acid ethyl ester pentadecanylorcinol, ethylhexylorceric acid, p-ethylhexylorceric acid ethylester ethylhexylorcinol, p-cyclohexylmethylorserine Acid, p-cyclohexylmethylorceric acid ethyl ester cyclohexylmethylorcinol, p-hydroxyethylhexylorceric acid methyl ester, p-hydroxyethylhexylorceric acid hydroxyethylhexylorcinol, etc.), umbelic acid, brefeldin, oxydesvera Trol, resorcinol derivative (4-cyclohexylresorcinol), 3-hydroxyketone compound (1,5-bis (p-hydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (o, p-di) Droxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (p-hydroxyphenyl-m-methoxyphenyl) -2-hydroxypentan-4-one, etc.), 1,3-diketone compounds (1 , 5-bis (p-hydroxyphenyl) -2,4-pentanedione, 1,5-bis (o, p-dihydroxyphenyl) -2,4-pentanedione, 1,5-bis (p-hydroxyphenyl- m-methoxyphenyl) -2,4-pentanedione), bishydroxybenzyl amides, γ-aminobutyric acid or its derivatives (N-methyl-γ-aminobutyric acid, N-dimethyl-γ-aminobutyric acid, γ-amino) Butyric acid oleyl ester, etc.), hydrogen peroxide, zinc peroxide, placenta extract, lucinol, silk extract, acacia extract, acerola extract, ichibi (winter position) extract, weeping birch extract, quellus extract, chestnut extract, kameba hikokoshi extract , Kuroba Nahi-Kokoshi extract, Toki-shiki (life-extending grass) extract, Seri extract, buckwheat extract, Davilia extract, Nazuna extract, Fujiba kama (Orchid grass) extract, chamomile extract, mulberry extract, gardenia extract, Japanese cypress extract, burnet extract, clara extract, mugwort extract, honeysuckle extract , Yellowfin extract, dokudami extract, pine-hodo extract, barley extract, scotch extract, hop extract, hawthorn extract, eucalyptus extract, yarrow extract, altea extract, cinnamon extract, mandarin extract, hamamelis extract, yamagwa extract, bellflower extract, toshishi extract, continued Suicho extract, sprayed extract, maize extract, senkyu extract, dokkatsu extract, psycho extract, boufu extract, kingfish extract, oxon extract, peony skin extract Peony extract, Geranium thunbergii extract, kudzu root extract, licorice extract, gallnut extract, aloe extract, Cimicifuga extract, safflower extract, green tea extract, black tea extract, include Uncaria gambir Roxburgh extract, and the like.

(3) Melanocyte melanin production inhibitor
Specifically, lobeline or lobeline derivatives, liquiritin derivatives (eg, liquiritin-α-glucoside, liquiritin-α-maltoside), phenylchroman derivatives, chromone derivatives (2-butylchromone, 2-pentylchromone, 2-heptylchromone, 2 -Nonylchromone, 2-hexadecylchromone, 2- (1-ethylpentyl) chromone, 2-butyl-7-methoxychromone, 2-pentyl-7-methoxychromone, 2-heptyl-7-methoxychromone, 2-nonyl- 7-methoxychromone, 2-pentadecyl-7-methoxychromone, 2- (1-ethylpentyl) -7-methoxychromone, 7-hydroxy-2-methylchromone, 7-hydroxy-2-butylchromone, 7-hydroxy- 2-pentylchromone, 7-hydroxy-2-heptylchromone, 7-hydroxy-2-nonylchromone, 7-hydroxy-2-pentadecylchromone, 7-hydro Cis-2- (1-ethylpentyl) chromone), azelaic acid derivatives (azelaic acid monoalkyl ester, azelaic acid dialkyl ester, etc.), phosphatidylglucosamine, lysophosphatidylglucosamine, phenylhydroquinone, 3-β-D-glucopyrano Silmanur, 3-β-D-maltopyranosylmanur, substituted amino acid derivatives (DL-N-formyl-3- (1-naphthyl) alanine, DL-N-acetyl-3- (1-naphthyl) alanine, DL -N-propionyl-3- (1-naphthyl) alanine, DL-N-butyryl-3- (1-naphthyl) alanine, DL-N-isobutyryl-3- (1-naphthyl) alanine, DL-N-valeryl- 3- (1-naphthyl) alanine, DL-N-isovaleryl-3- (1-naphthyl) alanine, DL-N- (2-methylvaleryl) -3- (1-naphthyl) alanine, DL-N- (3- Methyl valeryl) -3- (1-naphthyl) alanine, DL-N- (4-methyl) Ruvalyl) -3- (1-naphthyl) alanine, DL-N-t-butylacetyl-3- (1-naphthyl) alanine, DL-N-pivaloyl-3- (1-naphthyl) alanine, DL-N-caproyl -3- (1-naphthyl) alanine, DL-N- (2-ethylhexanoyl) -3- (1-naphthyl) alanine, DL-N- (2-methylhexanoyl) -3- (1-naphthyl) Alanine, DL-N-Heptanoyl-3- (1-naphthyl) alanine, DL-N-octanoyl-3- (1-naphthyl) alanine, DL-N- (2-propylpentanoyl) -3- (1-naphthyl) ) Alanine, DL-N-nonanoyl-3- (1-naphthyl) alanine, DL-N-decanoyl-3- (1-naphthyl) alanine, DL-N-undecanoyl-3- (1-naphthyl) alanine, DL- N-dodecanoyl-3- (1-naphthyl) alanine, DL-N-tridecanoyl-3- (1-naphthyl) alanine, DL-N-tetradecanoyl-3- (1-naphthyl) alanine, DL-N-pentadecanoy -3- (1-naphthyl) alanine, DL-N-hexadecanoyl-3- (1-naphthyl) alanine, DL-N-heptadecanoyl-3- (1-naphthyl) alanine, DL-N-octadecanoyl- 3- (1-naphthyl) alanine, DL-N-nonadecanoyl-DL-3- (1-naphthyl) alanine, DL-N-icosanoyl-3- (1-naphthyl) alanine, DL-N-acroyl-3- ( 1-naphthyl) alanine, DL-N-crotoniloyl-3- (1-naphthyl) alanine, DL-N-methacryloyl-3- (1-naphthyl) alanine, DL-N-vinylacetyl-3- (1-naphthyl) Alanine, DL-N-cyclopropanoyl-3- (1-naphthyl) alanine, DL-N- (2-pentenoyl) -3- (1-naphthyl) alanine, DL-N- (4-pentenoyl) -3- (1-naphthyl) alanine, DL-N- (2-hexenoyl) -3- (1-naphthyl) alanine, DL-N- (3-hexenoyl) -3- (1-naphthyl) alanine, DL-N- ( 2-methyl-3-pente Yl) -3- (1-naphthyl) alanine, DL-N-cyclohexenoyl-3- (1-naphthyl) alanine, DL-N- (10-undecenoyl) -3- (1-naphthyl) alanine, DL-N-linoleyl-3- (1-naphthyl) alanine, DL-N-hydroxyacetyl-3- (1-naphthyl) alanine, DL-N- (6-hydroxycaproyl) -3- (1-naphthyl) Alanine, DL-N- (8-hydroxyoctanoyl) -3- (1-naphthyl) alanine, DL-N- (9-hydroxynonanoyl) -3- (1-naphthyl) alanine, DL-N- (10 -Hydroxydecanoyl) -3- (1-naphthyl) alanine, DL-N- (11-hydroxyundecanoyl) -3- (1-naphthyl) alanine, DL-N- (12-hydroxydecanoyl) -3 -(1-naphthyl) alanine, DL-N-benzoyl-3- (1-naphthyl) alanine, DL-N- (2-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3- Hydroxybenzoyl -3- (1-naphthyl) alanine, DL-N- (4-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (o-toluyl) -3- (1-naphthyl) alanine, DL -N- (m-toluyl) -3- (1-naphthyl) alanine, DL-N- (p-toluyl) -3- (1-naphthyl) alanine, DL-N- (1-naphthoyl) -3- ( 1-naphthyl) alanine, DL-N- (2-naphthoyl) -3- (1-naphthyl) alanine, DL-N- (2-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- ( 3-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (4-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (2-picoryl) -3- (1- Naphthyl) alanine, DL-N- (3-picolyloyl) -3- (1-naphthyl) alanine, DL-N- (4-picolyloyl) -3- (1-naphthyl) alanine, DL-N-phenylacetyl-3 -(1-Naphthyl) alanine, DL-N- (2-Phenylpropanoyl -3- (1-naphthyl) alanine, DL-N- (3-phenylbutyryl) -3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine, DL-N-valeryl-3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alaninamide, DL-N- (4-methylvaleryl) -3- (1- Naphthyl) alanine methyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine ethyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine propyl ester, DL- N- (4-methylvaleryl) -3- (1-naphthyl) alanine-N-butyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine pentyl ester, DL-N- (4- Methylvaleryl) -3- (1-naphthyl) alanine isopropyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine isobutyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine-t-butyl ester, etc.), benzolactam derivatives, indolactam derivatives, cedrol, guaiool, 1- (4-hydroxyphenithio) -2- Propanol, β-lactoglobulin, 2-methoxy-5-methylphenol, 5-ethyl-2-methoxyphenol, 5-N-propyl-2-methoxyphenol, 5-N-butyl-2-methoxyphenol, 5-N -Hexyl-2-methoxyphenol, 5-N-heptyl-2-methoxyphenol, 5-N-decyl-2-methoxyphenol, 5- (1,1-dimethylpropyl) -2-methoxyphenol, 5- (1 , 1-dimethylbutyl) -2-methoxyphenol, 5- (1,1-dimethylethyl) -2-methoxyphenol, 2-methoxy-5- (1-methylpentyl) phenol, 2-methoxy-5- (1 -Methylhexyl) phenol, 2-methoxy-5- (3-methylhexyl) ) Phenol, 2-methoxy-5- (6-methylheptyl) phenol, 5- (1,3-dimethylheptyl) -2-methoxyphenol, malvelin, ferguinol, sugiol, cryptojaponol, 1,5-bis [p -Hydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [o-hydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [2,4-dihydroxyphenyl] ] -1,4-pentadien-3-one, 1,5-bis [3-methoxy-4-hydroxyphenyl] -1,4-pentadien-3-one, haginin, agrimophor, agrimol, hydrangenol or its Derivatives, alkylresorcinol or its derivatives (such as 4-N-butylresorcinol), aristolone, caramenene (such as caramenene, 7-hydroxycaramenene, 5-hydroxycaramenene, 7-methoxycaramenene), trans-umbe Acid, N-α-benzoyl-L-arginine, N-α-benzoyl-L-arginine ethyl ester or N-α-benzoyl-L-arginine ethyl ester, 5-methyl-2 (3H) -furanone, 2-butene -4-Orido, 2-hydroxymethylfuran, 2,5-dimethyl-4-hydroxy-3 (2H) -furanone, 2-formylfuran, 3-formylfuran, methyl α-furyl ketone, furfuryl acetate, 2-hydroxy -3-methyl-2-cyclopenten-1-one, 2-hydroxy-3,5-dimethyl-2-cyclopenten-1-one, 2,5-dimethyl-4-hydroxy-3 (2H) -thiophenone, 2- Hydroxy-3-ethyl-2-cyclopenten-1-one, tetronic acid, pentanedione, iminodibenzyls (2,2'-iminodibenzyl, imipramine, imipramine hydrochloride, desipramine, desipramine hydrochloride, chlorimipramine, trimipramine, etc. ), Dibenzocyclohe Tadienes (amitriptyline, amitriptyline hydrochloride, nortriptyline, noxiptylline, etc.), tetrahydrocopalol glycosides (ketotifen fumarate, labda-8 (17), 13-dien-15-ol, tetrahydromanol, tetrahydrocoparol, tetrahydro Copalol glucoside, tetrahydrocoparol galactoside, tetrahydrocoparol maltoside, tetrahydrocoparol cellobioside, tetrahydrocoparol maltotrioside, etc.), spiro ether compound, piokerin, phenothiazine compound, promethazine, alimemazine, alimemazine tartrate, triflupromazine , Levomepromazine, chlorpromazine, cyclandrate, 4-carboxymethyloxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3- (3- Ruboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) benzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4 -(3-carboxypropyl-1-oxy) -2-methoxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy)- 2-hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid, 4- (10-carbamoyl) Decan-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) benzoic acid, 4- (4-hydroxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- ( 4-acetoxybutyl-1-oxy) benzoic acid, 4- (4-acetoxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-etho Cycarbonylpropyl-1-oxy) -2-hydroxybenzoic acid, 3- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-methoxybutyl-1-oxy) -2 -Hydroxybenzoic acid, 4- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3- (3-carboxypropyl-1-oxy) 2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 6- (3- Carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) -2-hydroxybenzoic acid Acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid, hydroxytrimethyl Cyclohexanes (2-hydroxy-4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -1-butene, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2-butene, 4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 3-methyl-3-hydroxy-5- ( 2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-5- ( 2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -3-pentene, 3-methyl- 3-Hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -1-pentene, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane ) -2-Pentene, 2-Hydroxy-4 -(2,2,6-trimethyl-1-yl-cyclohexane) butane and other monosaccharides, disaccharides or trisaccharide glycosides), escinol, parahydroxycinnamic acid-4- (2,2,6-trimethyl) -Yl-cyclohexane) -2-butyl ester monosaccharide, disaccharide or trisaccharide glycoside, ondisaponin, bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin, senegin, 4- (2,2,6 -Torime
Tyl-1-yl-cyclohexane) -2-keto-butane, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto-butane, 4- (2,2,6- Trimethyl-1-yl-cyclohexane) -2-keto-3-butene, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto-3-butene (β-ionone), Lp-hydroxyphenylglycine, Dp-hydroxyphenylglycine, N-benzyloxycarbonyl-Lp-hydroxyphenylglycine, N-benzyloxycarbonyl-Dp-hydroxyphenylglycine, N-benzoyl-Lp-hydroxyphenylglycine, N-benzoyl- Dp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Dp-hydroxyphenylglycine, N- (p-hydroxybenzoyl) -Lp-hydroxyphenylglycine , N- (p-hydroxybe Nzoyl) -Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine, N-acetyl-Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine ethyl ester, N-acetyl-Dp-hydroxyphenylglycine Ethyl ester, N-acetyl-Lp-hydroxyphenylglycinamide, N-acetyl-Dp-hydroxyphenylglycinamide, Lp-methoxyphenylglycine, Dp-methoxyphenylglycine, Lp-methoxyphenylglycine hydrochloride, Dp-methoxyphenylglycine Hydrochloride, 4-hydroxy-3-methoxy-L-phenylglycine, 4-hydroxy-3-methoxy-D-phenylglycine, Lp-hydroxyphenylglycine ethylamide, Dp-hydroxyphenylglycine ethylamide, N-tert-butoxy Carbonyl-Lp-hydroxyphenylglycine, N -tert-butoxycarbonyl-Dp-hydroxyphenylglycine, N-tert-butoxycarbonyl-Lp-methoxyphenylglycine, N-tert-butoxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp -Methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxyphenylglycine benzyl ester hydrochloride, N-9-fluorenyl Methyloxycarbonyl-Dp-methoxyphenylglycine benzyl ester hydrochloride, Lp-hydroxyphenylglycinamide, Dp-hydroxyphenylglycine amide, Lp-hydroxyphenylglycine allyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine allyl ester p -Toluenesulfonate, Lp- Droxyphenylglycine benzyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine benzyl ester p-toluenesulfonate, Lp-hydroxyphenylglycine ethyl ester, Dp-hydroxyphenylglycine ethyl ester, Lp-hydroxyphenylglycine ethyl ester Hydrochloride, Dp-hydroxyphenyl glycine ethyl ester hydrochloride, Lp-hydroxyphenyl glycine methyl ester, Dp-hydroxyphenyl glycine methyl ester, etc., 1,3-diallylindane-2-carboxylic acids, stachybosines, pheophorbide derivatives, eleucerin, Isoeleucerin or 4-β-hydroxyisoereucerine, eleucerinol, spiroketal derivatives (2- (2,4-hexadinylidene) -1,6-dioxaspiro [4.5] dec-3-ene, 2- (2-hexynyl ) -1,6-dioxaspiro [4.4] non-3-ene, 2-((4-methylphenyl) methylidene) -6,6-dioxaspiro [4.4] non-3-ene, 2- (2-hexenylidene) -6,6-Dioxaspiro [4.5] dec-3-ene, 2- (2-hexenylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-hexyl-1,6-dioxaspiro [4.4] nonane 2- (2-hexenyl) -1,6-dioxaspiro [4.4] nonane, 2- (2-hexynyl) -1,6-dioxaspiro [4.4] nonane, 2-pentyl-1,6-dioxaspiro [4.4] nonane 1,6-dioxaspiro [4.4] nonane, 1,6-dioxaspiro [4.5] decane, 1,7-dioxaspiro [5.5] undecane, 2,3-benzo-4,4-dimethyl-1,6-dioxaspiro [4.4 Nonane, 3,4-benzo-2-pentyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-hexyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2 -Octyl-1 , 6-Dioxaspiro [4.4] nonane, 2-hexyl-9,9-dimethyl-1,6-dioxaspiro [4.4] nonane, 2- (2,4-hexadiynylidene) -1,6-dioxaspiro [4.4] nona -3-ene, etc.), malvalic acid, phosphonic acid derivatives or salts thereof, aspergillomalasmin, aminophosphonic acid derivatives or salts thereof, diphenhydramine or salts thereof, pregnenolone or derivatives thereof, lutein, farnesyl isopropanol derivatives, hexahydrofarnesyl acetone 4-benzoylamino-2-hydroxybenzoic acid, 5-benzoylamino-2-hydroxybenzoic acid, 4-benzoylaminobenzoic acid, 4- (1-naphthoylamino) -2-hydroxybenzoic acid, 5- (1 -Naphthoylamino) -2-hydroxybenzoic acid, 4- (2-naphthoylamino) -2-hydroxybenzoic acid, 5- (2-naphthoylamino) -2-hydroxybenzoic acid Acid, 4- (1-naphthoylamino) benzoic acid, 4- (2-naphthoylamino) benzoic acid, 4-phenylaminocarbonylbenzoic acid, 4-phenylaminocarbonyl-2-hydroxybenzoic acid, 5-phenylamino Carbonyl-2-hydroxybenzoic acid, 4- (1-naphthylaminocarbonyl) benzoic acid, 4- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid Acid, 4- (2-naphthylaminocarbonyl) benzoic acid, 4- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, hexahydrofarnesyl isopropanol Derivatives, borneol-p-hydroxycinnamate glucoside, borneol-p-hydroxycinnamate maltoside, borneol-p-hydroxy Cinnamic acid ester maltotrioside, cinnamic acid-4- (2,2,6-trimethyl-yl-cyclohexane) -2-butyl ester derivative, 2,4-dihydroxybenzophenone, 1- (2,4-dihydroxyphenyl) -Ethanone (2 ', 4'-dihydroxyacetophenone), 1- (2,4-dihydroxyphenyl) -1-propanone (2', 4'-dihydroxypropiophenone), 1- (2,4-dihydroxyphenyl) -1-butanone, 1- (2,4-dihydroxyphenyl) -1-pentanone, 1- (2,4-dihydroxyphenyl) -1-hexanone, 1- (2,4-dihydroxyphenyl) -1-heptanone, 1- (2,4-dihydroxyphenyl) -1-octanone, 1- (2,4-dihydroxyphenyl) -1-nonanone, 1- (2,4-dihydroxyphenyl) -1-decanone, 1- (2, 4-dihydroxyphenyl) -1-undecanone, 1- (2,4-dihydroxyphenyl) -1-dodecanone, 1- (2,4- Dihydroxyphenyl) -1-tetradecanone, 1- (2,4-dihydroxyphenyl) -1-hexadecanone, 1- (2,4-dihydroxyphenyl) -1-octadecanone, 1- (2-hydroxy-4-methoxyphenyl) -Ethanone (2'-hydroxy-4'-methoxyacetophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-propanone (2'-hydroxy-4'-methoxypropiophenone), 1- (2 -Hydroxy-4-methoxyphenyl) -1-butanone, 1- (2-hydroxy-4-methoxyphenyl) -1-pentanone, 1- (2-hydroxy-4-methoxyphenyl) -1-hexanone, 1- ( 2-hydroxy-4-methoxyphenyl) -1-heptanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octanone, 1- (2-hydroxy-4-methoxyphenyl) -1-nonanone, 1- (2-hydroxy-4-methoxyphenyl) -1-decanone, 1- (2-hydroxy-4-methoxy) Ciphenyl) -1-undecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-dodecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-tetradecanone, 1- (2-hydroxy-4- Methoxyphenyl) -1-hexadecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octadecanone, 1- (4-hydroxy-2-methoxyphenyl) -ethanone (4'-hydroxy-2'-methoxyacetophenone) ), 1- (4-hydroxy-2-methoxyphenyl) -1-propanone (4'-hydroxy-2'-methoxypropiophenone), 1- (2,4-dimethoxyphenyl) -ethanone (2 ', 4 '-Dimethoxyacetophenone), 1- (2,4-dimethoxyphenyl) -1-propanone (2', 4'-dimethoxypropiophenone), lactone derivative (1,6-dioxaspiro [4.4] nonane-2,7- Dione, 1,6-dioxaspiro [4.5] decane-2,7-dione, 4-tridecanolide 4-dodecanolide, 4-undecanolide, 4-decanolide, 4-nonanolide, 4-octanolide, 4-heptanolide, 5-dodecanolide, 5-undecanolide, 5-decanolide, 5-nonanolide, 5-octanolide, 2-undecen-4- Orido, 2-Decene-4-Olide, 2-Nonene-4-Olide, 2-Heptene-4-Olide, 2-Undecen-5-Olide, 2-Decene-5-Olide, 2-Nonene-5-Olide, 2-octene-5-olide, 4-methyl-4-dodecanolide, 4-methyl-4-undecanolide, 4-methyl-4-decanolide, 4-methyl-4-nonanolide, 4-methyl-4-heptanolide, 5- Methyl-5-dodecanolide, 5-methyl-5-undecanolide, 5-methyl-5-decanolide, 5-methyl-5-nonanolide, 5-methyl-5-octanolide, 2-methoxycarbonyl-4-dodecanolide, 2-methoxy Carbonyl-4-undecanolide, 2-methoxycarbonyl-4-decanolide, 2-methoxycar Nyl-4-nonanolide, 2-methoxycarbonyl-4-heptanolide, 2-methoxycarbonyl-5-undecanolide, 2-methoxycarbonyl-5-decanolide, 2-methoxycarbonyl-5-nonanolide, 2-methoxycarbonyl-5-octanolide 2-allyl-4-undecanolide, 2-allyl-5-decanolide, 2-allyl-4-nonanolide, 2-pentyl-4-undecanolide, 2-pentyl-4-nonanolide, 2-methyl-4-undecanolide, 2 -Methyl-4-nonanolide, 2- (4-hydroxybutyl) -4-undecanolide, 2- (4-hydroxybutyl) -4-nonanolide, 2- (4-hydroxybutyl) -5-decanolide, 5-propyloxy -4-pentanolide, 5-allyloxy-4-pentanolide, 5- (2-hydroxyethoxy) -4-pentanolide, 8-hydroxy-4-octanolide, 6-propyloxy-5-hexanolide, 6-allyloxy-5-hexanolide , 6- (2- Hydroxyethoxy) -5-hexanolide, 9-hydroxy-5-nonanolide, etc.), ethinomycin, iriflorental, iriparidal, 2'-8-C-glucosyl-7-methylaloesol coumaroyl ester, 2'-8- C-Glucosyl-7-methylaloesol cinnamoyl ester, chloropyramine, anise extract, aloe extract, itadori (tiger cane root) extract, seaweed extract, shrimp extract, katsumeshi (Kameko) extract, ogi (yellow tuna) extract , Paramecium (calocon) extract, Onamomi (Tempura) extract, Oni Yagara (Tempa) extract, Oyster extract, Ginseng extract, Oyaku extract, Pumpkin extract, Gama (Yellow yellow) extract, Kansui extract, Kimizuki (Senkuru) Grass) extract, black moji extract, black spruce extract, sisal Sisal extract, Saximas button extract, Chinese button extract, Chinese ginseng extract, Oshima cherry extract, Oya cherry extract, Bean cherry extract, Takane cherry extract, Kohigan extract, Sato cherry extract, Zion extract, Shiro extract, Shirobana Iris extract, ginseng extract, potato beetle extract, diamondfish extract, primrose extract, toshishi extract, bean extract, Japanese pear extract, sagebrush extract, yarrow extract, dill extract, honey beetle extract, Clams extract, Hitotsuba (stone persimmon) extract, Himegama (cranberry) extract, peony extract, floral blanka extract, hamula extract, sagebrush extract, hill O extract, sandalwood extract, red mushroom extract (reishi mushroom extract), swordfish (beneficial herb) extract, river willow extract, red willow extract, cat willow extract, catfish willow extract, quince willow extract, cory willow extract, unryu willow extract, yama willow extract, weeping willow Willow extract, Chinese cabbage extract, Fox willow extract, Doronoki extract, Japanese yam extract, Agave mid-autumn, Aono Agave extract, Fu
Crested Agave Extract, Mitsumata Extract, Aonori Extract, Usubaaonori Extract, Susioonori Extract, Hiraaonori Extract, Bowuaonori Extract, Hosoeda Aonori Extract, Kombu Extract, Macombu Extract, Resilibum Extract, Hosome Kombu Extract, Mitsuishi Kombu Extract, Wakame Extract Aowakame extract, hijiki extract, hibamata extract, sea urchin extract, sea bass extract, sea bream water extract, red sea urchin extract, sea urchin extract, sea urchin extract, sea bass extract, sea urchin extract, seaweed extract Extract, giraffe rhinoceros extract, juniper ginseng rhinoceros extract, tsunomata extract, ibottsu nomata extract, malvatsu nomata extract, Lakotoji extract, Sugi nori extract, Shikinori extract, Kainori extract, Yakuzusa extract, Urabo shiyahaz extract, Umiuchiwa extract, Ishimozuku extract, Misjikonbu extract, Atsuba misji extract, Isomok extract, Nagashima mok extract, Shimomoku extract, Nemosa extract , Tatsumoku Extract, Yatsutama Tamoku Extract, Umitorano Extract, Oba Moku Extract, Fusis Mimoku Extract, Haha Moku Extract, Yoremok Extract, Sawtooth Moku Extract, Psyllium Moku Extract, Mukadenori Extract, Nuraxa Extract, Cronouraxa Extract, Oomkadenori Extract, Oomkadenori Extract Steller's root extract, Sponge extract, Fushitsunagi extract, Himefushitsunagi extract, Hirohafushitsugi extract, Black Zoekisu, Kobusozoekisu, Hanesozoekisu, Sozonohanaekisu, brush Saki sawtooth Hiba extract, Thira extract, duck over Tede bruises franc extract, Hamaikaekisu, port Leo Verde extract, Nabo Negro extract, Schisandra chinensis extract, Matsubusa extract, Binankazura extract, and the like.

(4) Melanin production promoter Specifically, salicylic acid or a salt thereof and derivatives thereof (salicylic acid glucoside, salicylic acid fatty acid ester, salicylic acid alcohol ether, salicylic acid amides, etc.), salicyl alcohol or a salt thereof and derivatives thereof, apigenin, Mentoflavone, Salamander extract, Udo extract, Shishido extract, Nirinso extract, Oak extract, Bovine Taxus extract, Cuckoo thistle extract, Gypsophila extract Extract, jasmine (pine licorice) extract, hollyhock extract, scallop extract, Arabidopsis thaliana extract, lily of the valley extract, sawnose extract, deco extract, eucommia extract Squid (Butcher Bloom) Extract, Teppouri Extract, Tokiwa Mansaku Extract, Groundnut Extract, Niwarushi Extract, Nadeshiko Extract, Michiyanagi Extract, Elderflower Extract, Morohaya Extract Zakifujime extract, Ryokakou extract, Ajigusa extract, Shellfish extract (cockle extract, green mussel extract, oyster extract, European oyster extract, scallop extract, clam extract, clam extract, snail extract, red mussel extract, red mussel extract, abalone extract, Sazae extract, bi-extract, etc.).

(5) Humectant Specifically, ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, pentyl glycol, hexylene glycol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,6-hexanediol, glycerin, erythritol, Pentaerythritol, dipentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lath Polyhydric alcohols such as tititol, maltitol, sicilitol, laminitol, valienamine, validamine, and validatol, gum arabic, benzoin rubber, dammar gum, guaiac fat, Irish moss, Karaya gum, tragacanth gum, carob gum, quinseed, agar or its derivatives, casein , Glucose, galactose, mannose, xylose, fructose, maltose, isomaltose, cellobiose, gentiobiose, trehalose, cordobiose, laminaribiose, nigerose, cellobiose, sambibiose, neohesperidose, apiose, hammamellose, streptose, hydroxystreptose Toose, 2-methylerythrose or derivatives thereof, 2-methylerythronolactone, my Loin, cladinose, acneose, alkanose, olivomai course, chromose, ebamise, vinerose, nogarose, billenose, nobiose, moenuronic acid, galosamine, cibirosamine, N-acylcansosamine, vancosamine, evanitrose, rubranitrose, tetronitrose, pyralose, α -Sugars such as octose, trioxacalcinose, aldogalose, blastminosin or esters thereof, trehalose or derivatives thereof, D-mannosamine and derivatives thereof, isomaltoligosaccharide (panose), primeverose or derivatives thereof, dextrin, gelatin, pectin, Hydroxyl with added alkylene (C2-C4) oxide such as starch, carrageenan, carboxymethyl chitin or chitosan, ethylene oxide Alkyl (C2-C4) chitin or chitosan, low molecular chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or salt thereof, 1, 3-β-glucan, 1,4-β-glucan, 1,6-β-glucan, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose, carboxyethylcellulose, sodium carboxyethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, nitrocellulose, crystalline cellulose , Hydroxypropyl methylcellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyethylene oxide and polypropylene Polyalkylene oxides such as oxides or cross-linked polymers thereof, carboxyvinyl polymers, water-soluble polymers such as polyethyleneimine, dermatan sulfate, keratan sulfate, glycerin fatty acid pyrrolidone carboxylic acid esters, glycerin fatty acid acetyl amino acid esters, pyrrolidone carboxyl Acid or salt thereof, polyaspartic acid or salt thereof, polyglutamic acid or salt thereof, polylysine or salt thereof, sodium lactate, hydantoin and derivatives thereof, Np-vinylbenzyl-D-cellobionamide, Np-vinylbenzyl-D-lactone Amide, Np-vinylbenzyl-D-maltonamide, Np-vinylbenzyl-D-gluconamide, glucosyloxyethyl methacrylate, galactosyloxypropyl acrylate, mannosyloxyethyl methacrylate, glutamyl Lysine, glutaurine, 1,2,4-butanetriol, caran-3,4-diol, azoxaponin (3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -sophoradiol, 3- o- [β-D-glucopyranosyl-3-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -azuxapo Genol, 3-o- [β-D-glucopyranosyl] -28-o- [β-D-glucopyranosyl-β-D-glucopyranosyl] -dipsogenic acid, 3-o- [α-L-rhamnopyranosyl-β-D -Glucopyranosyl-β-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -29-o- [β-D -Glucopyranosyl-β-D-glucopyranosyl] -Azoxapogenol, etc.), Aoki (Aoki) extract, Aogiri extract, Kenashia Ogiri (Toho) extract, Red pepper ( Red red hemp) extract, red clover extract, Aki larch extract, Aguahe (Omanten palm) extract, Malva morning glory extract, morning glory (Chicken) extract, Athira (Shokuyo kanna) extract, oilseed rape extract, Amachazul extract, Amana extract , Ayuyu extract, Hagetou extract, Homogetou extract, Senninoku extract, Sugi Morigetou extract, Hosoaogeito extract, Aogatetou extract, Hariyuyu extract, Aozulan extract, Amaranthus hippochondriax extract, Aristolomeria (Yurizuisen) extract, Arcana (Alcanna) extract, Algarrobo (Cabbage) extract, Aloe vera extract, Rabbit (Kanshin grass) extract, Yew (first place) extract, Strawberry extract, Carob bean extract, Inazuna (Tailexi) extract, Rice extract, Dog Occasion extract, Iwa tobacco extract, Iwahiba extract, Iwamatsu extract, Wheat extract, Duckweed extract, Usbenitachai extract, Usenia extract, Unyadegato extract, Enokitake mushroom ) Extract, eringi extract, pre-lotus eringi extract, ogatahouken extract, oguruma (civil engineering incense) extract, euglena (cereal essence) extract, oka extract, okazeri (serpentine) extract, okra extract, onidokoroko extract, tokoro extract , Nagadokoro (hikai) extract, Ononis extract, Oyuko extract, Oyster extract, Ginseng extract, Gaku hydrangea extract, Cascara grada extract, Gypsophila extract, Panax ginseng extract, Kaniwa extract, Carnation extract, Gerberae , Camcoma (camo duck) extract, Color extract, Oats extract, Karin (Kiso) extract, Kawara Psycho (Sugar), Kawajisha extract, Kawaranadeshiko (Shitake) extract, Ezokawaranadeko (Soba, Oats) extract , Kantarasa extract, Kikutaniku extract, quinoa (quinoa) extract, cabbage extract, kiwi extract, cucumber extract, gyory (Nishikawa willow) Kudzu extract, kokujinjin (yellow flower bud) extract, cupuasu extract, gumbai nazuna (Sekimei, Sekimeishi) extract, Kemponashi (Kigushi) extract, gekkavidin (Beautiful under the moon) extract, Koolen (Huo Ren) extract, coconut extract, cosmos Extract, coconut lees extract, rice oil extract Konjac extract, saffron extract, sapodilla extract, sangre degrad (croton) extract, sanchinin ginseng (37 ginseng) extract, shea (carite) extract, cyanoki extract, shiitake extract (shiitake) extract, shimeji extract , Hinshimeji extract, Shakashimeji extract, Hatake shimeji extract, Oshiroi shimeji extract, Beech shimeji extract, Honjimeshi extract, Shirotamagitake extract, Shimokurene extract, Saishin extract, Cactus extract, Janohige (bara winter) extract, Shukukonka miso extract, Zhu Zan hydrangea (Tsuneyama) extract, white-faced butterfly extract, white-leafed adzuki bean (chicken bone) extract, ginkgo biloba (Mizuka, Mizuka flower, Shencho flower) extract, watermelon (Western phoenix) extract, Suzu-Psycho (Xu-long moth) extract, purslane (horse tooth soap, horse Toothpaste extract, secrecy Kisses, cherry blossoms extract, Japanese apricots extract, Japanese apricots extract, Japanese apricots extract, Honsekoku extract, Japanese butterflies extract, Shikakekokukoku extract, Kibananosekoku extract, Cedron extract, Zenia oyster extract, celery extract Shinren) extract, Japanese radish extract, Takasaburo extract, Tachidokoro (hikai) extract, Dahlia (tenjiku button) extract, Talwe extract, Senganshi extract, Sojutsu extract, Chankapiedora (Kidachikokankanso) extract, Tulip extract, Chorogi extract, Tsukuritake (mushroom) extract, camellia extract, clover (lacquered licorice) extract, Tounabena (river cut) extract, corn extract, corn hair (southern cocoon) extract, Tokusa ( Bandit) extract, ash (crust) extract, Turkish Kyary extract, jujube extract, vertical bean (sword bean) extract, jujube (large cocoon) extract, navena (continuous) extract, sea cucumber extract, namban ramie (seed) extract, iois violet Extract, nutmeg extract, Nemum extract, Nebu extract, Nebi extract, Nemurioki extract, Digokubana (community) extract, Nogateto extract, Hylindough extract, Hauchiwa extract, Hauchi bean extract, Papaya extract, Pahalobobo extract, Balata rubber extract, Haratake extract, White oharatake extract Usukimori nokasa extract, haran extract, pariurus (Amanita spp.) Extract, balsamina (crane licorice, bitter gourd) extract, harlindough extract, hand daikai (胖大海) extract, hygurum dahlia extract, beet extract, fly fly , Sunflower extract, bell pepper extract, Himezu (Tenpo) extract, Himematsutake (Kawariharatake, Hiromatsutake) extract, Euphorbicus extract, Brazilian licorice extract, hazelnut extract, loofah extract, red snapper extract, squirrel extract Bakigi extract, narcissus extract, nendo extract, Hahagigi Kokia (geum sorghum) extract, spinach (Akansen, Acute pupa, periosteum) extract, Falcona extract, Hosobakirinso (Keiten No.7) extract, Jojoba extract, Borage ( (Rurichisha) extract, Bordeaux extract, Hononiku (meat jugo, Daiki) extract, Honsekkok (iron skin stone, sparrow mountain stone) extract, maca extract, macadamia nut extract, margaret (mokushungiku) extract, tamanozenhalen extract, Kyukonkinrenka D , Matatabi extract, Matsukasa extract, Matsuhodo (茯苓) extract, Matico (Cordon sillo) extract, Quince extract, Malene (Biloud mud squid) extract, Manzanya (Andesca mite) extract, Mizusobako extract, Mizuasagao (dragon) Tongue extract), green mint extract, wheat straw extract, munya extract, murasakiki kibu extract, murmur sakikibu extract Extract, palm extract, yabu tobacco (crane candy, Tenmeisei) extract, maroni extract, mokka extract, lily extract, ligan (Raimaru) extract, lime extract, rye extract, rakkyo extract, shallot extract, apple extract, gentian extract Ganoderma (Wicking, Toothpick Nucleus) Extract, Astragalus Extract, Yokuinin Extract, Mini Sasanishiki Extract, Chlorella Bulgaris Extract, Chlorella Pyrenoid Extract, Chlorella Ellipsoidia Extract, Macrocystis pirifera Extract, Yuikiri Extract, Tosakanori Extract, Cypridosa extract, Amakusaori extract, Aoimidori extract, Kawanori extract, Marimo extract, Japanese squirrel extract, Ezoyahaz extract, Habanori extract, Atlantic scallop extract, Cotton bud extract, Aname extract, Japanese squirrel extract, Trolocomb extract, Antarctic extract, Black allame extract, Black cat Ashikonbu extract, Ainu Wakame extract, Tigaiso extract, Ezoi Shige extract, Yabanemoku extract, Trumpet extract, Uganomok extract, Jolomok Kiss, Hiemoku Extract, Tamanashimoku Extract, Honda Walla Extract, Sugi Moku Extract, Bovine Kenori Extract, Susabi Nori Extract, Akebono Mozuku Extract, Salamander Extract, Fusanori Extract, Hosobanamino Hana Extract, Hanaf nori Extract, Itaf nori Extract, Kaginori Extract, Milin Extract, Milin Extract Kikutosaka extract, Ezonameshi extract, Ibaranori extract, Kagibaranori extract, Saidaibara extract, Tachiibara extract, Ogonori extract, Tsurussilamo extract, Hachijogusamodoki extract, Otsunori extract, Red-backed ginseng extract, Natto fungus culture metabolite, Natto Examples include extract, loofah water, birch (white birch) or red pine sap.

(6) Cell activator / metabolic activator Specifically, vitamin A group: retinol or a salt thereof, and derivatives thereof (retinyl linoleate, retinyl linolenate, retinyl oleate, retinyl arachidonate, etc.) Fatty acid esters, etc.), retinal or salts thereof and derivatives thereof, dehydroretinal or salts thereof and derivatives thereof, retinoic acid or salts thereof and derivatives thereof, retinoic acid analogs (4-[[[8- (3,5 -Dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3-methylphenyl) -2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[[8- (4 -Methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methylphenyl) -2-naphthalenyl] carbonyl] amino] Benzoic acid, 4-[[[8- (3,4-dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2,4-dimethylphenyl) -2-naphthalenyl ] Carbonyl] amino] benzoic acid, 4-[[[8- (2-isopropylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-ethylphenyl) -2-naphthalenyl ] Carbonyl] amino] benzoic acid, 4-[[[8- (2-fluorophenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methoxyphenyl) -2-naphthalenyl ] Carbonyl] amino] benzoic acid, 4-[[(8-benzyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[(E) -2- (8-phenyl-2-naphthalenyl) propenyl] benzoic acid ), Retinoic acid derivatives (4-hydroxyphenylretinamide), retinoid analogs (4-[[(5,6-dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5,8- Trimethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[( 5,6-dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) -Carbonyl] amino] benzoic acid, 4- (E)-[2- (5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) -1-propenyl] benzoic acid, 4-[[ (5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) oxy] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2) -(Naphthalenyl) carbonyl] amino] repose Acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] oxy] benzoic acid, 4-[[5,6-dihydro-5,5-dimethyl -8- (2-Fluorophenyl) -naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5,6-trimethyl] -8-phenyl-2- (naphthalenyl) carbonyl] Amino] benzoic acid, 4-[[((5,6-dihydro-5,5,7-trimethyl-8-phenyl-2-naphthalenyl) carbonyl) benzoic acid, 4-[[(E)-(5,6- Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] vinyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl ] Sulfamil] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] sulfamyl] carbonyl] benzoic acid, 4-[[(5,6-dihydro- 5,5-Dimethyl-8-fe Nyl) -2-naphthalenyl] ethyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] thiocarbonyl] amino] benzoic acid, 4- [ [[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] methyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8 -Phenyl) -2-naphthalenyl] methyl] oxy] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthenyl] oxy] methyl] benzoic acid, 4 -[[[((5,6-dihydro-5,5-dimethyl-8- (2,4-dimethylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[((5,6- Dihydro-5,5-dimethyl-8- (4-methylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-Naphthalenyl] ethyl] repose Acid 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] sulfamyl] methyl] benzoic acid, 4-[[(5,6-dihydro-5,5 -Dimethyl-8-phenyl) -2-naphthalenyl] methyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] amino] thiocarbonyl ] Benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] sulfamyl] benzoic acid, 4-[[[((5,6-dihydro- 5,5-dimethyl-8-phenyl-2-naphthalenyl] amino] methyl] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] Amino] -2-hydroxybenzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-nitrobenzoic acid, 4- [ [[(5,6-dihydro- 5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-fluorobenzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2-) Naphthalenyl] carbonyl] amino] -2-methoxybenzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8- (2-naphthalene)]-2-naphthalenyl] carbonyl] amino] benzoic acid 4-[[(5,6-dihydro-8-phenyl-2-naphthalenyl) carbonyl] aminobenzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl ) Carbonyl] amino] -3-fluorobenzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) carbonyl] amino] -3-methylbenzoic acid, 4- [[(5,8,10,10a-Tetrahydro-10,10-dimethyl-9-phenyl-2-anthracenyl) carbonyl] amino] benzoic acid, 4-[[(1,1-dimethyl-3-phenyl-1H1 -In -5-yl) amino] carbonyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-inden-5-yl-oxymethyl) benzoic acid, 4- [2- (1,1 -Dimethyl-3-phenyl-1H-inden-5-yl) vinyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-indene-5-carbonyl) amino] benzoic acid), carotene or Salts thereof and derivatives thereof (α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthine, lutein, zeaxanthin, isozeaxanthin, rhodoxanthine, capsanthin, crocetin and other carotenoids), lycopene or a salt thereof and derivatives thereof, vitamin B Group: Thiamine or salts thereof and derivatives thereof (thiamine hydrochloride, thiamine disulfide, bisbenchamine, bisbutiamine, thiamine monophosphate disulfide, benf Thiamine, chicotiamine, octothiamine, dicetiamine, fursultiamine, prosultiamine, astaxanthinthiamine phosphate diester, etc.), thiamine sulfate, riboflavin or its salts and derivatives thereof (flavin adenine dinucleotide, flavin mononucleotide, riboflavin phosphate) Diester, 1-β-D-ribofuranosyl nicotinamide pyrophosphate diester, 1-β-D-ribofuranosyl nicotinic acid, etc.), pyridoxine or a salt thereof and derivatives thereof (pyridoxine 3,4-dipalmitate, 3 , 4-dicaprylic acid pyridoxine, pyridoxine sulfate diester, etc.), pyridoxal or a salt thereof and derivatives thereof, pyridoxamine or a salt thereof and derivatives thereof, cyanocobalamin or a salt thereof and derivatives thereof, cobalamins (me Lucobalamin, adenosylcobalamin, hydroxocobalamin, aquacobalamin, etc.), folic acid or a salt thereof and derivatives thereof, nicotinic acid or a salt thereof and derivatives thereof, pantothenic acid or a salt thereof and derivatives thereof, biotin or a salt thereof and their Derivatives, choline or salts thereof and derivatives thereof, inositol or salts thereof and derivatives thereof, vitamin C group: ascorbic acid or salts thereof and derivatives thereof, vitamin D group: ergocalciferol or salts thereof and derivatives thereof, Calciferol and its salts and their derivatives (1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanol Cholecalciferol, [1R, 4R] -1α-hydroxy-22-[(1-hydroxy-1-methyl -2-Cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1R, 4S] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-Cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1S, 4R] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-Cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1S, 4S] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, etc.), dihydrotaxosterol or a salt thereof and derivatives thereof, vitamin E group: tocopherol or a salt thereof, and Derivatives thereof, tocotrienol or a salt thereof and derivatives thereof, ubiquinone or a salt thereof and derivatives thereof, vitamin K group: phyto Dione or a salt thereof and derivatives thereof, menaquinone or a salt thereof and derivatives thereof, menadione or a salt thereof and derivatives thereof, menadiol or a salt thereof and derivatives thereof, vitamin F group: linoleic acid or a salt thereof and derivatives thereof, Linolenic acid or a salt thereof and derivatives thereof, arachidonic acid or a salt thereof and derivatives thereof, carnitine or a salt thereof and derivatives thereof, ferulic acid or a salt thereof and derivatives thereof, γ-oryzanol or a salt thereof and derivatives thereof Orotic acid or a salt thereof and derivatives thereof, vitamin P group: rutin or a salt thereof and derivatives thereof, eriocitrin or a salt thereof and derivatives thereof, hesperidin or a salt thereof and derivatives thereof, vitamin L group: anthranilic acid or Its salty And derivatives thereof, adenylthiomethylpentose or a salt thereof and derivatives thereof, vitamin U group: methylmethionine sulfonium chloride or a derivative thereof, valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, Asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine or a derivative thereof (N-octyloxycarbonyl-β-alanyl-L-histidine, N- Dodecyloxycarbonyl-β-alanyl-L-histidine, N- (12-amino-1-oxododecyl) -L-histidine, N-2-ethylhexyloxycarbonyl-β-alanyl-L-histidine hydrochloride, N-he Sadecyloxycarbonyl-β-alanyl-L-histidine, N-octylaminocarbonyl-β-alanyl-L-histidine, N-dodecylaminocarbonyl-β-alanyl-L-histidine, N-dodecylsulfonyl-β-alanyl- L-histidine, N-dodecylamino-oxalyl-β-alanyl-L-histidine, etc.) and their amino acids such as sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid , Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, succinic acid and other α-hydroxy acids, 2-hydroxycarboxylic acids (methyl lactic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid, 2-hydroxyheptanoic acid, 2-hydroxyoctanoic acid, 2-hydroxynonanoic acid, 2-hydroxydecanoic acid, 2-hydroxyundecanoic acid, α-hydro Xylauric acid, α-hydroxymyristic acid, α-hydroxypalmitic acid, α-hydroxystearic acid, α-hydroxyarachidonic acid, cerebronic acid, α-hydroxynervonic acid, mandelic acid, benzylic acid, phenyllactic acid, atrolactic acid, 2- (4′-hydroxyphenyl) -2-hydroxyethanoic acid, 2- (4′-chlorophenyl) -2-hydroxyethanoic acid, 2- (3′-hydroxy-4′-methoxyphenyl) -2-hydroxyethanoic acid, 2- (4'-hydroxy-3'-methoxyphenyl) -2-hydroxyethanoic acid, 3- (2'-hydroxyphenyl) -2-hydroxypropanoic acid, 3- (4'-hydroxyphenyl) -2-hydroxy Propanoic acid, 2- (3 ', 4'-dihydroxyphenyl) -2-hydroxyethanoic acid, glyceric acid, erythronic acid, ribbon acid, arabinonic acid, xylonic acid, lyxonic acid, aronic acid, altronic acid, g Luconic acid, mannonic acid, gulonic acid, idonic acid, galactonic acid, talonic acid, glucoheptonic acid, galactoheptonic acid, tartronic acid, mucinic acid, etc.), polyhydroxycarboxylic acid or hydroxypolycarboxylic acids (gluconolactone, galactonolactone, Glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, sugar lactone, pantoyl lactone, glucoheptonolactone, mannonolactone, galactoheptonolactone, etc.), 2-keto acids (glyoxylic acid, methyl 2-ketoethanoate) Benzoylformic acid, methyl benzoylformate, ethyl benzoylformate, phenylpyruvic acid, methyl phenylpyruvate, ethyl phenylpyruvate, 2-ketobutanoic acid, 2-ketopentanoic acid, 2-ketohexanoic acid, 2-ketoheptanoic acid, 2-ketooctaoctane Acid, 2-ketododecanoic acid, methyl 2-ketooctanoate, etc.), quinic acid, isocitric acid, tropic acid, tretocanic acid, 3-chlorolactic acid, cerebronic acid, citramalic acid, agaricinic acid, alolithic acid, pantoic acid, lactobionic acid, Hexulosonic acid, photosensitizer 301, hinokitiol, pantothenic acid or derivative thereof, allantoin, pentadecanoic acid glyceride, linolenic acid or derivative thereof, eicosapentaenoic acid or derivative thereof, docosahexaenoic acid or derivative thereof, estradiol, etenyl estradiol, antiallol or Its glycoside, Liononiresinol or its glycoside, Rhodendendrol or its glycoside, Platyphyronol or its glycoside, Lactone compound (D-glucurono-6,3-lactone, α-D-glucoheptonic -γ-lactone, δ-gluc Lonolactone, α, β-glucooctonic-γ-lactone, L-glonic-γ-lactone, γ-D-galactonolactone, D-saccharide-1,4-lactone, D-saccharide-3,6-lactone, D-ribonic-γ-lactone, α-butyrolactone, γ-butyrolactone, α-octanoic lactone, γ-octanoic lactone, nonanoic lactone, γ-valerolactone, D-manninoic-δ-lactone, D-xyleuric -δ-lactone, D-arabinoic-δ-lactone, stearoyl-δ-gluconolactone, DL-pantolactone, palmitoyl-DL-pantolactone, etc.), 3-hydroxy-3,4-dicarboxy-1,4- Butanolide or its derivative, 6-benzylaminopurine or its derivative, 1,4-diazadicyclooctane, 2,5-dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzo Orchid, rutin, tektrigenin 7-xylosyl glucoside, captopril, alacepril, lisinopril, enalapril, delapril, benazepril, cilazapril, imidapril, quinapril, trandelapril, perindopril, temocapril, losartan, endothelin, galactomannin trimethyl polymer Glycine, proteoglycan, lactic acid bacteria extract, lactic acid bacteria culture extract, lactic acid bacteria fermented milk extract, bifidobacteria extract, bifidobacteria culture broth extract, bifidobacteria fermented milk extract, placenta extract, ganoderma extract, spleen extract, thymus extract, yeast extract, yeast Culture fluid extract, yeast fermentation extract, filamentous fungus extract, filamentous fungus culture fluid extract, basidiomycete extract, basidiomycete culture fluid extract, bacterial cell disruption extract, bacterial culture fluid extract, culture Human dermal cell disruption extract, red ginger extract, fennel extract, barley extract, barley extract, oakuri higotai (Yeoju leakage, indigo piercing) extract, corn fly Extract, Hypericum perforatum extract, Dutch jellied extract, Dutch honey beet extract, Silkworm extract, Roman chamomile extract, Garcinia extract, Kawarani carrot (blue agate) extract, Kakiran extract, Quillaja extract, Kinlan extract, Ginkgo biloba extract, Calendula extract, Sakaneran (Ezosacaneran) ) Extract, Sababagin orchid extract, Sawagurumi (Yamatomo) extract, Shimotsuke extract, Shajin extract, Sumomo extract, Japanese walnut extract, Japanese horsetail extract, Pineapple extract, Chinese plover extract, Japanese cypress , Beech extract, physalis (Torone) extract, maitake (maiko) extract, misohagi (senju-na) extract, mukuge (kiso) extract, mukuroji (longevity skin) extract, bean sprout, eucalyptus extract, yukinoshita (tiger ear grass) ) Extract, Suabisimus extract, Lettuce extract, Aloe extract, Ogon extract, Tonka bean extract, Gentianana extract, Burdock extract, Shikon extract, Carrot extract, Hamamelis extract, Hop extract, Yokuinin extract, Odrichos extract, Assembly Extract, Toki Extract, Toki-Senka Extract, Achacha Extract, Hypericum Extract, Cucumber Extract, Papaver Extract, Rosemary Extract, Parsley Extract, Sanadagusa Extract, Fukurin Amiji Extract, Gobble Comb Extract, Oyster Comb Extract, Onikobue Examples include kiss, gohei comb extract, nagacombu extract, pea comb extract, large dwarf extract, rattle extract, flatfish extract, benimozuku extract, hosobenimozuku extract, kagekinori extract, ezotosaka extract, silamo extract, birch extract and the like.

(7) Antioxidants Specifically, ascorbic acid or a salt thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl hydroxyprophosphate, 5- o-α-D-Glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate Calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L -Ascorbic acid sulfate aluminum Nium salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyranosyl -L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl-L -Ascorbic acid, 6-o-alkylascorbic acid potassium ester potassium salt, 6-o-alkylascorbic acid phosphate calci Um salt, 6-o-alkyl ascorbic acid phosphate barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o-alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl ascorbine Acid phosphate ester diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine Salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate Cholesterol ester, L-ascorbyl palmitate, L-isopalmitate Scorbyl, L-ascorbyl dipalmitate, L-ascorbyl diisopalmitate, L-ascorbyl stearate, L-ascorbyl isostearate, L-ascorbyl distearate, L-ascorbyl diisostearate, L-ascorbyl myristate, isomyristate L-ascorbyl, dimyristic acid L-ascorbyl, diisomyristic acid L-ascorbyl, 2-ethylhexanoic acid L-ascorbyl, di-2-ethylhexanoic acid L-ascorbyl, oleic acid L-ascorbic acid, 2-o-α -D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D- Glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitin Ester, L-Ascorbic acid tetralauric acid ester, L-Ascorbic acid tetra-2-ethylhexanoic acid ester, L-Ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, Lu, L-ascorbine Acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L -Ascorbyl triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl]- 4'-acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid diester, ascorbic acid Cytol-binding derivatives, ascorbic acid phosphoramide derivatives, ascorbic acid arbutin conjugates, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivatives, ascorbic acid sialic acid derivatives, etc.), stearates, tocopherols or salts thereof and derivatives thereof (α-tocopherol, β -Tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate, tocopherol succinate, tocopherol Linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tokov Lyl glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α- Tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ -Tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L- γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- (sulfoethylamino) -3- (α-tocopheryl-6 -Iroxy) propan-2-ol 1- (carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl ] Cysteine, S- [3- (α-Tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy)- 2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol) , Γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orote Dihydropyridine derivatives (methyl-3-phenyl-2-propenyl 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) pyridine-3,5-dicarboxylate and its salts), Benzochroman derivative, nordihydrogua ceretenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, coenzyme Qn (n = 7-10), pyrroloquinoline quinone, propyl gallate, Sesamol, sesamorin, gossypol, maritimaine, sulfretin, xanthene-2,7-diols, caffeoylquinic acids, propolis, carotenoids (α-carotene, β-carotene, γ-carotene, lycopene, lutein, violaxanthin, spirolo Xanthine, spheroidene, astaxanthin, etc.), fluorotanni , Akebi extract, Achacha extract, Oolongcha extract, Dutch sweetfish extract, Canola extract, Kumquat extract, Gobaishi extract, Ganoderma (Oldgrass) extract, Sesame extract, Sesame cell extract, Sesame seeds Extract, rice bran extract, pomegranate extract, salamander extract, pear extract, Daio extract, tomato extract, Nanten extract, Noami (Daisen) extract, Neubara extract, paprika extract, Pistachio extract, loquat extract, betel wax (large garment, coconut) extract, Japanese bursa extract, bokeh (wooden) extract, Hosobao guruma extract, mao (mao) extract, mimosa extract, mebouki extract, himeuma willow extract, willow deer extract, cotton wisteria Mimei Flower) extract, Chlamydomonas extract, a Yukimo extract, Japanese walnut extract, Red-crowned plover extract, Hypericum extract, Hamelis extract, Clove extract, Melissa extract, Enmiso extract, Birch extract, Salvia extract, Rosemary extract, Southern fruit extract, Ginkgo biloba extract, Green tea extract, Clove extract, etc. Can be mentioned.

(8) Reactive oxygen scavenger / radical scavenger Specifically, superoxide dismutase, catalase, glutathione peroxidase, bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or derivatives thereof, gallic acid or salts thereof, and their Derivatives, curcumin or salts thereof and derivatives thereof, transferrin, ceruloplasmin, coenzyme Qn (n = 7 to 10), uric acid, bilirubin, metallothionein, stilbengaloyl glycoside (3,5,4′-trihydroxystilbene 4 '-o-β-D- (6 "galloyl) glucopyranoside, 3,5,4'-trihydroxystilbene 4'-o-β-D- (2" galloyl) glucopyranoside, etc.), chlorogenic acid phospholipid ester, chlorogen Acid sphingosine ester and derivatives thereof, chlorogenic acid glycolipid ester, Acid sugar ester, chlorogenic acid sterol ester, thiazole derivative or salt thereof (2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxyphenyl) thiazole, 2- (3,4-di) Ethoxyphenyl) -4- [3-carboxy-4-hydroxy-5- (2-methyl-2-propenyl) phenyl] thiazole and 2- (3,4-diethoxyphenyl) -4- (3-carboxy-4 -Hydroxy-5-methylphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- (3-carboxy-5-methoxyphenyl) thiazole,), hydroxymatylesinol, allohydroxymatylesinol, hydantoin Derivatives, Akaminoki (logwood) extract, Akamegasiwa (Akabudoi) extract, Akamino Akane extract, Acacia akane extract, Akane (Root) extract, Hydrangea (hydrangea) extract, Abemaki extract, Fig , Ginkgo biloba extract, Asparagus extract, Plum (Plum) extract, Vulgaris extract, Prunus quercivorus extract, Estragon extract, Enju (Scarlet flower, Satsuma rice) extract, Kashiwa (Salmon tree, coconut leaf) extract , Genus extract, birch extract, birch extract, cucumber extract Extract, Sasa (Amber) Extract, Perilla Extract, Ajizo Extract, Chimmen Diso Extract, Catamen Diso Extract, Peonies (Gakuen) Extract, Quercus Extract, Japanese Quail Extract, Crape Myrtle Extract, Zicopi Extract, Shirakashi Extract, White Clover (Clover) Extract, Horseradish D , Black tea extract, green tea extract, camellia tea extract, tencha (tea) extract, tender eel extract, naniwai rose (gold cherry) extract, peanut (peanut) extract, kei extract, nikkei extract, ceylon nicky extract, yabuni kei (cinnamon) extract, keishi ( (Keishi branch) extract, Nozenkazura (Ryokan flower) extract, lotus (lotus) extract, Chinese cabbage extract, hadakamugi extract, Hanasuge (my mother) extract, Hermanus (maikai flower) extract, rose (rose) extract, barbasco extract, spinach extract, Beech extract, American beech extract, Dog beech extract, European beech extract, Convolvulus extract, Hosobaokera extract, Button (peony) extract, Mallorum extract Extract, Naminohanaekisu, Yukari extract, bombardier Yukari extract, Azusaekisu, basil extract, woodworking (climate) extract, Hime Fuuro extract, lemon grass extract, and the like.

(9) Fat metabolism promoter Specifically, phthalazine derivatives (4-ethyl-1- (β-hydroxyethylamino) phthalazine, 4-N-propyl-1- (β-hydroxyethylamino) phthalazine, 4-N -Butyl-1- (β-hydroxyethylamino) phthalazine, 4-N-butyl-1- (β-hydroxypropylamino) phthalazine, etc.), xanthine derivatives (caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, Diprofylline, proxyphylline and oxtriphyrin, etc.), Aotsuki-rafuji (wooden cocoon) extract, thistle extract, ale thistle extract, mallow thistle extract, scrub thistle extract, noel thistle extract, abalone thistle extract, cacao extract, elcampuri extract, giant crab raft (Prevention) Extract, Gajutsu (Amber) Extract, Carax Salmon Man Extract Pepper extract ) Extract, cinnamon extract, primrose extract, red ginseng extract, ginseng extract (dragon gall) extract, naginata kouju extract, banana extract, puerh tea (pure tea) extract, plum extract, boufu (windproof) extract and the like.

(10) UV protective agent / UV absorption accelerator Specifically, benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone) -5-sulfonate sodium, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), 1,2-dihydroxy-4- (2-hydroxyethyl) benzene derivatives (1 -(2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) ) -3-Rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (2-acetyl-4- (3,4-dihy)) Loxicinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (2-acetyl-6- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl- 3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (6- (4 -Hydroxy-3-methoxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl)- 1-methoxyethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-hydroxyethyl-3,4-dihydroxybenzene, 1 -(2- (6- (3,4-dihydroxycinnamoyl) -3-xylosyl) glucosyl) Ru-3,4-dihydroxybenzene, 1- (2- (3-allosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- ( 3-glucosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (3-arosyl-6- (3-hydroxy-4-) Methoxycinnamoyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2 -(3- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (2- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4 -Dihydroxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydride Roxybenzene, etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc.), methoxycinnamate derivatives (ethyl paramethoxycinnamate, Isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, di-2-methoxycinnamate mono-2-ethylhexanoate glyceryl, etc.), anthranilic acid derivatives (such as methyl anthranilate) ), Urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyriline Gin derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, pyridoxine derivatives, pyridoxal derivatives, pyridoxamine derivatives, amethoflavone, neosacranin, 6-dehydrocaine, triazine derivatives (4,4 '4 "-(1,3,5-triazine-2,4,6-triyltriimino) trisbenzoic acid tris-2-ethylhexyl etc.), phosphatidyl chromanol derivatives (1,2-dilaurolylglycero-3- Phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-dimyristoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6'-hydroxychroman, 1,2-dipalmitoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl -6'-hydroxychroman, 1,2 -Distearoyl glycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-dialachidonyl glycero-3-phospho-2 '-Hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6'-hydroxychroman, 1-myristoyl-2-palmitoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5' , 7 ', 8'-Tetramethyl-6'-hydroxychroman, 1-myristoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-tetramethyl- 6'-hydroxychroman, 1-palmitoyl-2-myristoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-palmitoyl- 2-stearoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-stearoyl-2-myristoylglycero-3-phospho-2 '-Hydroxyme Til-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-stearoyl-2-palmitoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7' , 8'-tetramethyl-6'-hydroxychroman, etc.), L-carnosine zinc complex, umbelliferone, esculin, benzyl cinnamate, cinoxalate, oxybenzone, dioxybenzone, octabenzone, thrisobenzone, benzoresorcinol, arbutin, guaiazulene, Shikonin, baicalin, baicalein, berberine, neoheliopan, chlorophylls, xanthophylls, escalol, zinc oxide, talc, kaolin, anthracnose (benzoic acid) extract, hub extract, giant clover extract, cassava extract, kawatake extract, islet jellyfish extract , Hassai extract, Spirulina extract AIA Casio extract, funori Nou storm extract, Hime Gelidium extract, high Gelidium extract, Oobusaekisu, Chinorimoekisu, and the like.

(11) Astringents Specifically, succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannins (tannic acid, Hamelian tannins, acer tannins, tetragalloyl glucose, pentagalloyl glucose, hexagalloyl glucose, heptagalloyl glucose, octagalloyl glucose, nonagaroyl glucose, decagalloyl glucose, undecagalloyl glucose, dodecagaro Gallotannins such as ilglucose, telimaglandin I, telimaglandin II, casarictin, peduncraggin, geraniin, isotarkebin, granatin A, granatin B, ketulinic acid, keblagic acid, casuarine, nuphalin, procyanidin -2, ellagitannins such as thiacinensin A, thiacinensin B, etc.), red grape extract, azuki bean (red bean) extract, altea extract, nettle extract, cascarilla extract, kapok extract, guarana extract, ezo strawberry extract, Dutch strawberry extract, shrimp Gara Strawberry Extract, Nawashiro Strawberry Extract, Momiji Strawberry Extract, European Raspberry Extract, Kidachi Aloe Extract, Hawthorn Extract, Kousuihakka Extract, Cowberry (Koshitachi) Extract, Cola Vera Extract, Sugarcane Extract, Sinah Honoki Extract, Honeysuckle (Gin Silver Flower, Shinobifu) Extract , Horsetail extract, Japanese larch extract, elder extract, dandelion extract, centalium extract, white dandelion extract, mouko dandelion extract, vine azuki bean extract , Tsurutsuchiakebi extract, Teuchigurumi extract, Tormentilla extract, Novara extract, Buttercup extract, Hagoromogusa extract, Castor extract, Grape extract, Prunes extract, Veronica extract, Bisnaga extract, Bilberry extract, Manshugurumi extract, Mitsuga wrinkle extract, Myrrh extract, Melissa Examples include extract, witch hazel extract, bay willow extract, latania (chlamelia) extract, lemon extract, chickpea extract and the like.

(12) Anti-inflammatory agent / interleukin production inhibitor / histamine release inhibitor Specifically, quinolinone derivatives, dibenzooxepin derivatives, thiotroposin, phthalimide derivatives, flurbiprofen, felbinac, bufexamac, suprofen, 1,4 -Diphenylpropylpiperazine derivatives, carxin compounds, chromanol glycosides (2- (α-D-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol), ictamol, indomethacin, kaolin, diphenhydramine hydrochloride , D-camphor, DL-camphor, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, diphenhydramine hydrochloride, clemastine fumarate, cyproheptadine hydrochloride, Acid promethazine, piperazine derivatives, α-D-phenylglycoside derivatives, glycyrrhizic acid or salts thereof and derivatives thereof (α-glycyrrhizic acid, β-glycyrrhizic acid, α-glycyrrhizic acid methyl ester, β-glycyrrhizic acid methyl ester, α- Trisodium glycyrrhizinate, monopotassium α-glycyrrhizinate, dipotassium α-glycyrrhizinate, monoammonium α-glycyrrhizinate, trisodium β-glycyrrhizinate, monopotassium β-glycyrrhizinate, dipotassium β-glycyrrhizinate, β-glycyrrhizic acid mono Ammonium), glycyrrhetinic acid or salts thereof, and derivatives thereof (α-glycyrrhetinic acid, β-glycyrrhetinic acid, stearyl of α-glycyrrhetinic acid, stearyl of β-glycyrrhetinic acid, pyridoxine of α-glycyrrhetinic acid) , Β-glycyrrhetinic acid pyridoxine, α-glycyrrhetinic acid glycerin, β-glycyrrhetinic acid glycerin, 3-succinyloxyglycyrrhetinic acid disodium, etc.), mefenamic acid, phenylbutazone, ibuprofen, ketoprofen, allantoin, calcium pantothenate, pantothenylethyl Panthenol such as ether or salts thereof and derivatives thereof, ε-aminocaproic acid, diclofenac sodium, tranexamic acid or derivatives thereof (trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-nitrobenzyloxycarbonyl Aminomethylcyclohexanecarboxylic acid, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-bromobenzyloxycarbo Ruaminomethylcyclohexanecarboxylic acid, trans-4-m-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methylbenzyloxycarbonylamino Methylcyclohexanecarboxylic acid, sodium trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylate, ammonium trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid Potassium acid, potassium trans-4-p-bromobenzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-m-chlorobenzyloxycarbo Calcium ruaminomethylcyclohexanecarboxylate, trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylate magnesium, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexanecarboxylate monoethanolamine, trans-4-t- Butyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- ( 3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) Chlohexanecarboxylic acid, sodium trans-4-t-butyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylate, trans-4- (p-biphenylisopropyloxy) Carbonylaminomethyl) calcium cyclohexanecarboxylate, trans-4- (3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) magnesium cyclohexanecarboxylate, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid monoethano -Luamine, trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4-methylsulfonylethyloxycarbonyl Ruaminomethylcyclohexanecarboxylic acid, trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) sodium cyclohexanecarboxylate, potassium trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4- (pyridine -4'-methyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexane Potassium carboxylate, trans-4- (pyridine-4′-methyloxycarbonylaminomethyl) cyclohexanecarboxylate sodium, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexane Potassium carboxylate, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylate, etc.), sulfatide, astaxanthin fatty acid diester (astaxanthin dilaurate ester, astaxanthin dimyristate ester, astaxanthin dipentadecanoate ester, astaxanthin diester Palmitic acid ester, astaxanthin dipalmitooleic acid ester, astaxanthin diheptadecanoic acid ester, astaxanthin dielaidic acid ester, astaxanthin diricinoleic acid ester, astaxanthin petrothelinic acid ester, astaxanthin vacsenate ester, astaxanthin eleostearic acid ester, astaxanthin Punicic acid ester, Astaxa Nanthric acid ester, astaxanthin parinalic acid ester, astaxanthin gadoric acid ester, astaxanthin 5-eicosenoic acid ester, astaxanthin 5-docosenoic acid ester, astaxanthin cetolic acid ester, astaxanthin erucic acid ester, astaxanthin 5,13-docosadienoic acid ester, Astaxanthin ceracholic acid ester, astaxanthin decenoic acid ester, astaxanthin stering acid ester, astaxanthin dodecenoic acid ester, astaxanthin dioleic acid ester, astaxanthin distearic acid ester, astaxanthin dieicosapentaenoic acid ester, astaxanthin didocosahexaenoic acid ester, astaxanthin dilinoleic acid ester, Astaxanthin Giri Rexic acid ester, astaxanthin diarachidonic acid ester, etc.), astaxanthin diglycerophosphoric acid ester (astaxanthin diglycerophosphoric acid ester, astaxanthin lyserophosphoric acid palmitic acid, astaxanthing lyserophosphatidylcholine palmitic acid, astaxanthing lyserophosphatidylcholine DHA, astaxanthing lysero Phosphatidylinositol palmitic acid, astaxanthing lyserophosphatidylinositol DHA, astaxanthing lyserophosphatidylinositol linoleic acid, astaxanthing lyserophosphatidylcholine linoleic acid, steviol glycosides, benzimidazole derivatives (1- (2-ethoxy) Ethyl) -2- [1- (2- (4- (1- (4,4-dimethyl-2-oxazolin-2-yl)- 1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- (4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidine- 1-yl) ethyl) phenyl] -2-methylpropanoic acid, ethyl 2- [4- (2- (4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl ) Phenyl] -2-methylpropanate, 1- (2-ethoxyethyl) -2- [1- (2- (4- (1,1-dimethyl-2-hydroxyethyl) phenyl) ethyl) piperidine-4- Yl] -1H-benzimidazole, 1- (2-hydroxyethyl) -2- [1- (2- (4- (1- (4,4-dimethyl-oxazolin-2-yl) -1-methylethyl) Phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- (4- (1- (2-hydroxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl ) Fe Ru] -2-methylpropanoic acid), alanine derivatives or salts thereof (N- {3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5 -Carbonyl} -L-alanine, N- {3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl} -2-methylalanine, N- {3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl} -N-methyl-L-alanine etc.), thiazoline derivatives or Its salt (3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid, 4-isobutyl-3-methyl-2- [4- (3-Trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-ca Rubonic acid, etc.), chlorpheniramine maleate, diphenhydramine hydrochloride, diphenylpyraline hydrochloride, carbinoxamine maleate, hydrocortisone butyrate, sulfated acid mucopolysaccharide or salt thereof, sulfated dextran or salt thereof, fluoromethylhistidine or hydrochloride salt thereof, Histidine methyl ester or its hydrochloride salt, licorice extract, chicory extract, age extract, propolis, eye (Aiba) extract, asenyaku (Asenyaku) extract, avocado extract, amadokororo (tamatake) extract, amiga lily extract, baimo (shellfish mother) Extract, igakozorina (ground bile head) extract, ibukitoranoo extract, turmeric (depressed gold) extract, echina (hosobamurasakibarengiku extract), oren (yellow chain) extract, oguruma (turned over) extract, hypericum (young brother cut grass) extract, sea urchin extract , Oren Extract, cassia extract, chamomile extract (weed) extract, kawamidori extract, cormorant mugwort (bamboo chin moth) extract, watercress extract, kenashi sartorii rose (earthen soil, mountain return) extract, gentian extract, koki-sekoku extract, kakuhon (bamboo shoot, carp bonito) extract, Koryo Kyo (Kora Kaki) Extract, Gosho Strawberry (Cover Bonsai) Extract, Psychiaran Extract, Cherries Extract, Salvia (Sage) Extract, Diquitaris Extract, Linden Extract, Salamander Extract, Indian Bodge Extract, Shukushamitsu (Sanjin, Shredded Sand) ) Extract, juzudama extract, shirominanten (southern honey) extract, licorice ivy extract, s. Extract, Tachikaku Sou (Marika) Extract, Tamazaki Rakuji Extract, Tonin Extract, Chigaya Extract, Toga (Winter Eggplant) Extract, Dokudami (10 Medicines) Extract, Parsley (Netherlands Jelly) Extract, Hanabishi (Satsurishi, Shishitsuri) Extract, Hamasuge (Incense) (Bushi) extract, Hishi (Hishimi) extract, Bellows oyster extract, Japanese pod extract (southern rattan) extract, Bundou (mung bean) extract, Sandalwood extract, Butcher bloom extract, Pansy extract, Hosoba arabiku extract, Mizurutennansho ( (Tennan star) extract, pheasant (fruit) extract, miracle fruit extract, mulberry extract, peach (peach) extract, cornflower extract, yachi willow extract, mistletoe (willow parasite) extract, yabukouji (purple gold beef) extract, sagebrush extract, mugwort ) Extract, Rosemary (Mannenrou) Kisses, Scots wings extract, Jujusmo extract, Tamajusmo extract, Mizojusmo extract, Urushigusa extract, Siwahige extract, Akamok extract, Togemoku extract, Akaba extract, Maruba akaba extract, Harigane extract, Dulse extract, Una extract, Belladonna extract, Hoonoki Extract, Harunire (crusted skin, white skin, persimmon leaf) extract, Aozuzuran extract, Sakaneran extract, Sasabagin orchid extract, Chinese cabbage extract (including varieties and origins) extract, Valerian extract, Primrose extract, Nematode extract, Gyoen extract , Honeysuckle extract, touki extract, fennel extract, peppermint extract, and the like.

(13) Antiseborrheic agents Specifically, chroman derivatives, pyridoxine or salts thereof and derivatives thereof, pyridoxal or salts thereof and derivatives thereof, pyridoxamine or salts thereof and derivatives thereof, sulfur, Asa (asako) extract , Nettle extract (continuous), Dutch mustard (watercress) extract, valerian extract (valerian root) extract, clematis extract, bear sebassikis, scallop extract, rosewood extract, horse chestnut extract, soybean (soybean) extract, Tokinsenka (marigold) Examples include extract, Chinese yam extract, yam extract, nosen-halen extract, Japanese cypress poppy (sect winter flower, winter winter leaf) extract, japonica extract, giant kelp extract, hijirimen extract, proboscis extract, hyus banori extract and the like.

(14) Antibacterial agents Specifically, acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T , Salicy powder, iodine compound, iodoform, 1-alkylcarbapenem compound, N-substituted azepane derivative or salt thereof, sorbic acid or salt thereof, propionic acid or salt thereof, salicylic acid or salt thereof, dehydroacetic acid, parahydroxybenzoic acid ester 2-keto-3-deoxyoctanoic acid fatty acid ester, inositol deoxy derivatives (such as quercitol), inositol unsaturated derivatives (such as chonditol), inositol dimethyl ether, methyl inositol, inositol Ether, inosamine, deoxyinosadiamine, shikimic acid, quinic acid, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol , Thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc Pyridione, chlorobutanol, isopropylmethylphenol, elemol, tiveverol, patchouli alcohol, nonionic surfactant (polyoxyethylene lauryl ether, poly Xylethylene nonylphenyl ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactants (cetyltrimethylammonium bromide, benzalkonium chloride) Benzethonium chloride, methyl rosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal violet, germal, photosensitizer 101, photosensitizer 201, photosensitizer 401, N-long chain acyl basic amino acid derivatives and acids thereof Addition salt, zinc oxide, hinokitiol, propolis, cucumber extract, agi (Ayu) extract, asunaro extract, alpinia extract, katsudai (suzukuku) extract, Inubilu (Honagainbuyu) extract, Aogateto extract, Haribiyu extract, Ayuyu extract, Hagatou extract, Hosonagabiyu extract, Enmeiso extract, Warbler extract, Usbasaicin extract, Hanasaishin extract, Halibut extract, Ominaeshi (defeated sauce) extract Choi extract, Kahoku salamander extract, chamomile extract, linden extract, red linden extract, yellowfin extract, caraway extract, betel extract, kumazasa extract, cranberry extract, grapefruit extract, celosia (chicken crown flower, (Chicken cot) extract, bay bay laurel extract, cinnabar rose (moon flower) extract, copaiba balsam extract, yamazakura extract, edhigashira extract, miyazakura extract, yoshino cherry extract, casamikura extract, kanzakura extract, Sugar beet extract, white pepper extract, scabbard extract, birch extract, cinnamon extract, sorrel extract Sowka (grass) extract, onion extract, chicory extract, Korean senile (蕪 夷) extract, tsuruna (apricot) extract, tokon (root) extract, leek (coconut) extract, leek extract, peach extract, patchouli extract, Astragalus extract, cypress extract, pimenta extract, Acer palmatum extract, Blackberry extract, Hop extract, Makuri (sea herb) extract, Magnolia sprenger extract, Mizokakushi (half) Lotus) extract, bee extract, purple (purple) extract, moso-chiku extract, Pokeweed (commercial and commercial) extract, yucca extract, euglena extract, lavender extract, forsythia extract, syringen extract, prunus nomata extract, tochaka (yahazuzumata) extract, red-bellied extract, anaaosa extract, human rush extract, hirohano Listed are: Human rush extract, Ushua rush extract, Iroro extract, Ishige extract, Alame extract, Tamai taki extract, Tambanori extract, Katanori extract, Sakuranori extract, Fujimatsumo extract, Kawamokuzuku extract, Aokawa Mozuku extract, Himekawa Mozuku extract, Yakuchi extract It is done.

(15) Blood flow promoter / vascular stimulator Specifically, tocopherol or a salt thereof and derivatives thereof, tocotrienol or a salt thereof and derivatives thereof, cephalanthin, carpronium chloride, eugenol derivatives (acetyl eugenol, methyl eugenol, methyl isoeugenol) , Ethyl eugenol, ethyl isoeugenol, eugenol salicylate, etc.), minoxidil, pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, mint oil, L-menthol, camphor, benzyl nicotinate, cinnarizine, trazoline, acetylcholine, verapamil , Ikutamol, α-borneol, cyclandrate, nonylic acid valenylamide, capsaicin, gingerone, assembly extract, garlic extract, carrot extract , Aloe extract, Gentian extract, Toki extract, Ashitaba (Tomorrow) extract, Arnica extract, Ukiyagara (Sanryo) extract, Himewiku extract, Citrus unshiu (Chest) extract, Toucan beetle (coconut) extract, Oyster extract, Persimmon extract, Kina extract, goldfish extract, pine moth (horse whip grass) extract, gubijinsou extract, kohone (river bone) extract, burdock (beef bowl, beef coconut) extract, scallop (Yamabachi) extract, syringen extract, ginger (ginger) extract, Shobu (bamboo root, radish) extract, hawthorn extract, sea bream (Otaku) extract, Daidai (orange peel) extract, tanjin (dansang) extract, thyme extract, chiketsu carrot (bamboo ginseng) extract, tsurudokudami (what neck crab) extract , Carrot (Yoteba ginseng) extract, Capsicum (bansho) extract, Toki (toll) , Scotchworm extract (Sadako), Natsumikan extract, elderberry (bone graft) extract, hazelnut (coconut) extract, Hashiridokoro (roth root) extract, mint (light load, thin load leaf) extract, Hamabou Fu (beach wind) extract, Higotai extract , Fujimodoki (Chojizakura, Camellia) extract, Black currant extract, Bodaiju (Aoki tree) extract, Merirot extract, Yuzu extract, Loquat extract, Japanese jelly extract, Hibiscus extract, Rosehip extract and the like.

(16) Antiandrogens Specifically, follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendron, 4 ', 5,7-trihydroxy-8-prenylflavanone, 4', 5,7-tri Examples include hydroxy-8-prenyl flavone, 3,3 ′, 4 ′, 5,7-pentahydroxy-8-prenyl flavone, nicorandil, cyclosporic acid and the like.

(17) Inhibitors of structural proteolytic enzymes (malastase, elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme) / Structural proteolytic enzyme expression inhibitor Specifically, adenine derivatives (butanetriol-9-adenine and its phosphate adduct, propanediol-9-adenine and its phosphate adduct, pentanetriol-9-adenine and its Phosphoric acid adducts, carbostyril derivatives or salts thereof, dicarboxylic acids (glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, 1,9-nonamethylenedicarboxylic acid, 1,10-decamethylene Dicarboxylic ), Rosmarinic acid, ursolic acid, oleanolic acid, hydroxamic acid derivative, esculetin derivative, anthocyanidins, nordihydroguaiaretech acid, 20-carboxy-16-hydroxy-21-nor-5 α-7,9 (11)- Lanostadien-3,24-dione, ubiquinone, plastaquinone, yuglone, shikonin, quinizarin, alizarin, abietin, levopimar, betulin, α-amylin, catechin compounds (catechin, epigallocatechin, epigallocatechin gallate, epicatechin, epicatechin gallate, Catechin rhamnopyranoside catechin, etc.), diisopropyl fluorophosphate, (2R, 6R) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylic acid Dimethyl, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzylo Ci-4-hydroxyheptanedicarboxylic acid-1,7-diamide, (2R, 6R) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2R, 6R) -2,6-Dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2R, 6R) -2,6-dibenzyloxy-4- (tert- Butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy -4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R)- 2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R)- 2,4,6-trihydroxyheptane-1,7-dicarboxylic acid diamide, N, N'-bi [(1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, (2S, 6S)- 2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate, (2S, 6S) -2,6-dihydroxy-4- (tert-butyldimethyl) Silyloxy) heptane-1,7-dicarboxylate, (2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2S, 6S) -2,6-Dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N'-bis [(1S, 2R) -2-hydroxyindan-1- Yl]-(2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R)- 2-Hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy 4-hydroxyheptane-1,7-dicarboxylic acid diamide, 3-[[4- (4-fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclopentyl) -amino] -propionic acid, 4- [4- (4-Fluorophenoxy) -benzenesulfonylamino] -tetrahydropyran-4-carboxylic acid hydroxyamide, 4- [4- (4-chlorophenoxy) -benzenesulfonylmethyl] -tetrahydropyran-4-carboxylic acid hydroxyamide, 3 -[[4- (4-Fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclobutyl) -amino] -propionic acid, 4- (4'-chlorobiphenyl-4-yl) -2- [2- (1,3-dioxo-1,3-dihydroisoindol-2-yl) -ethyl] -4-oxobutyric acid, {1- [4- (4-fluorobenzyloxy) -benzenesulfonyl] -2-hydroxycarbamoyl Pipette Gin-3-yl) -carbamic acid isopropyl ester, 2- [4- (4-fluorophenoxy) -benzenesulfonylamino] -N-hydroxy-2-methylfuropionamide, 3- [4- (4-fluorophenoxy) ) -Benzenesulfonyl] -2, N-dihydroxyfuropionamide, 3- (4-phenoxybenzenesulfonyl) -7-oxabicyclo [2.2.1] heptane-2-carboxylic acid hydroxyamide, (4-benzylbenzyl)- [2- (2,2-dimethyl-1-methylcarbamoylpropylcarbamoyl) -4- (4′-fluorobiphenyl-4-yl) -butyl] -phosphinic acid, 2-amino-3- [4- (4- Fluorophenoxy) -benzenesulfonyl] -N-hydroxypropionamide, and N-hydroxy-2- (4-phenylpiperidine-1-sulfonyl) -acetamide, Iris japonicum extract, Nepenthes (summer hay) extract, o Bananas beetle (Banaba) extract, Barley hawthorn extract, Hawthorn (Yamako) extract, Calahoo (Koh-Pak) extract, Guava extract, Garbage (Gomicho) extract, Shazenso extract, Atlantic rose extract, Hypericum perforatum extract, Octopus (breeding) extract , Hina Taiko Kozuchi (cow knee) extract, Honoki (Japanese Koshoku, Park) extract, American grape extract, European grape extract, Yama grape extract, Mandarin extract, Misaki psycho (Shibahu) extract, Ogon extract, Hypericum extract, Clara extract, Mulberry extract , Cinnamon extract, gentian pepper extract, comfrey extract, salvia extract, elderberry extract, sea bream extract, button pi extract, Aozulan extract, sakaneran extract, sasabagin orchid extract, varieties and origin species No) extract, Aono agave extract, sisal hemp extract, Adenophortriphylla extract, and the like.

(18) Structural protein synthesis promoter Specifically, ethanolamine derivatives, pentoxyphyllin, serine derivatives, geraniol, crocetin, methyl 4- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-4- (3,5,5-trimethylhexyloxy) methyl benzoate, methyl 4-cyclohexylmethoxy-2-hydroxybenzoate, methyl 4- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4- (3,7- Methyl dimethyl-6-octenyloxy) -2-hydroxybenzoate, ethyl 3- (2-ethylhexyloxy) -5-hydroxybenzoate, methyl 5- (2-ethylhexyloxy) -2-hydroxybenzoate, 2- Hydroxy-5- (3,5,5-trimethylhexyloxy) methyl benzoate, methyl 5- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4-N-hexyloxy-2-hydroxy Methyl benzoate, methyl 2-hydroxy-4-N-octyloxybenzoate, methyl 4-N-decyloxy-2-hydroxybenzoate, methyl 5-N-hexyloxy-2-hydroxybenzoate, 4- (2- Ethylhexyloxy) -2-hydroxybenzoic acid, 2-hydroxy-4- (2,5,5-trimethylhexyloxy) benzoic acid, 4-cyclohexylmethoxy-2-hydroxybenzoic acid, 4- (2-cyclohexylethoxy)- 2-hydroxybenzoic acid, 4- (3,7-dimethyl-6-octenyloxy) -2-hydroxybenzoic acid, 3- (2-ethylhexyloxy) -5-hydroxybenzoic acid, 5- (2-ethylhexyloxy) ) -2-Hydroxybenzoic acid, 5- (2-ethylhexyloxy) -2-hydroxybenzoic acid, 2-hydroxy-5- (3,5,5-trimethylhexyloxy) benzoic acid, 5- (2-cyclohexylethoxy) ) -2-Hydroxybenzoic acid, 4-N-hexyl Oxy-2-hydroxybenzoic acid, 5-N-hexyloxy-2-hydroxybenzoic acid, 2-hydroxy-4-N-octyloxybenzoic acid, 4-N-decyloxy-2-hydroxybenzoic acid, N- (2 -Hydroxyethyl) -4- (2-ethylhexyloxy) -2-hydroxybenzamide, N-ethyl-4- (2-ethylhexyloxy) -2-hydroxybenzamide, 2-acetoxy-4-cyclohexylmethoxybenzoic acid, 4- (2-Ethylhexyloxy) -2-hydroxybenzoic acid sodium salt, 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid methyl ester, 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate, 5-{(2E) -3,7 dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate Ethyl, 3-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate, 3- (2E) -3,7-dimethyl-2,6-octadienyloxy} -5-hydroxybenzoate, 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy}- Ethyl 3-methoxybenzoate, 4-{(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy} -2-hydroxymethyl benzoate, 4-{(2E)- 3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid (2E) -3,7-dimethyl-2,6-octadienyl, 4-{(2E) -3,7-dimethyl- 2,6-octadienyloxy} -2-hydroxybenzoic acid, 5-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid, 3-{(2E ) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid, 3-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -5-hydroxy Benzoic acid, 2-hydroxy-4-{(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy} benzoic acid, 4-{(2E) -3,7-dimethyl - 2,6-octadienyloxy} -3-methoxybenzoic acid, 2-acetoxy-4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} benzoic acid, N- (2- Hydroxyethyl) -4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzamide, 4-{(2E) -3,7-dimethyl-2,6-octa Dienylamino} -2-hydroxybenzoic acid, dimethyl-2,6-octadienyloxy} benzoic acid, N- (2-hydroxyethyl) -4-{(2E) -3,7-dimethyl-2,6 -Octadienyloxy} -2-hydroxybenzamide, 4-{(2E) -3,7-dimethyl-2,6-octadienylamino} -2-hydroxybenzoic acid, 3-dodecyloxybenzoic acid, 3- (12-hydroxydodecyloxy) benzoic acid, 4-dodecyloxybenzoic acid, 4- (12-hydroxydodecyloxy) benzoic acid, 3- (12-hydroxyoctadecyloxy) benzoic acid, 4- (12-hydroxyocta Siloxy) benzoic acid, 3- (11-hydroxyundecyloxy) benzoic acid, 4- (11-hydroxyundecyloxy) benzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadi Enyloxy) benzoic acid, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, 3-[(2E, 6E) -3,7,11-trimethyl-2, 6,10-dodecatrienyloxy) benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4- [3,7- Dimethyl-9- (2,6,6-trimethyl-1-cyclohexen-1-yl) -2,4,6,8-nonatetraenyloxy] benzoic acid, 4- [3,4-dihydro-2,5 , 7,8-Tetramethyl-2- (4,8,12-trimethyltridecyl) -2H-1-benzopyran-6-oxy] benzoic acid, 4-[(2E, 6E) -3,7,11- Trimethyl-2,6,10-dodecatrienyloxy] benzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzamide, 4- (2-methyl 2-butenyloxy) benzamide, 4- (2-ethylhexyloxy) benzamide, 4-dodecyloxybenzamide, 4- (12-hydroxydodecyloxy) benzamide, 4- (12-hydroxyoctadecyloxy) benzamide, 4- (11 -Hydroxyundecyloxy) benzamide, 4- (10-hydroxydecyloxy) benzamide, 4-isostearyloxybenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11- Trimethyl-2,6,10-dodecatrienyloxy] benzamide, N, N-dimethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzamide N, N-di [(2E) -3,7-dimethyl-2,6-octadienyl] -4-aminobenzamide, 4- [N'-methoxycarbonyl-N-[(2E) -3,7-dimethyl -2,6-octadienylamino] benzamide, 4- [N-acetyl-N-[(2E) -3,7-dimethyl -2,6-octadienyl]] aminobenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2 -Hydroxybenzamide, N, N-diethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, pea extract, Tosakamodoki extract , Ikanoashi Extract, Hosobonori Extract, Novonori Extract, Igis Extract, Keigi Extract, Harigigi Extract, Hanagigi Extract, Usuba Watanagi Extract, Moroitogusa Extract, Fumoitusa Extract, Hanayagi Extract, Willow Tree Extract, Moyuyurena Extract Examples include Kori extract, Prunus extract, Sasabayana Ginori extract, horseradish extract, merbou extract and the like.

(19) Mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitors Specifically, anacardic acid or its derivatives (6-pentadecatrienylsalicylic acid methyl ether, 6-pentadecatrienylsalicylic acid ethyl ether, 6 -Pentadecatrienyl salicylic acid propyl ether, 6-pentadecatrienyl salicylic acid butyl ether, 6-pentadecatrienyl salicyl alcohol methyl ether, 6-pentadecatrienyl salicyl alcohol ethyl ether, 6-pentadecatrienyl salicyl alcohol propyl ether 6-pentadecatrienyl salicyl alcohol butyl ether, 6-pentadecatrienyl salicylaldehyde methyl ether, 6-pentadecatrienyl salicylaldehyde ethyl ether, 6-pentadecatrienyl salicyl aldehyde Dopropyl ether, 6-pentadecatrienyl salicylaldehyde butyl ether, 2-methyl ether-6-pentadecatrienyl cinnamic acid, 2-ethyl ether-6-pentadecatrienyl cinnamic acid, 2-propyl ether-6 -Pentadecatrienyl cinnamate, 2-butyl ether-6-pentadecatrienyl cinnamate, 2-methyl ether-6-pentadecatrienyl cinnamate alcohol, 2-ethyl ether-6-pentadecatrienyl cinnamate Skin alcohol, 2-propyl ether-6-pentadecatrienyl cinnamon alcohol, 2-butyl ether-6-pentadecatrienyl] cinnamon alcohol), polyisoprenylated benzophenone derivatives (garcinol, isogarcinol, xantho) Thymol, isoxanthothymol, gucciferon, etc.), Ikarisou extract, Yachima Taikiso (Yinyokukaku) extract, Narukoyuri extract, Kajikarumabanarukoyuri (Yellow spirit) extract, Oregano extract, Oshida extract, Onji extract, Spruce extract, Crow peony (Half summer) extract, Pheasant (fruit) extract, Japanese wolfberry (Bone skin) extract, Goshuyu extract, Senega extract, Sendan extract, Tamarind extract, Tarragon extract, Korean radish (Dahi) extract, Bee extract, Daisies extract, Milobaran extract, Himekuma willow extract , Mockin extract, Laurel extract, Yabusotatsu extract, Anaaasa extract, Macrocystis integolifolia extract, Neocitus Ruetkeana extract, Hiluxa extract, Oatweed extract, Caterpillar extract, Yatabegusa extract, Spotted rush extract, Ezo Nomata extract, Togetu no Mata extract, Fusaiwa mushroom extract, Hanemo extract, Mill extract, Chrome mill extract, Nagamil extract, Hiramil extract, Matsumo extract, Okinawa mozuku extract, Mozuku extract, Fukuronori extract, Kajime extract, Fukurofunori extract, Makhunori extract, Grape leaf extract, Sunflower extract, Astragalus extract, etc. are mentioned.

(20) Mucopolysaccharide synthesis promoter Specifically, stilbene derivatives or salts thereof, morgin or salts thereof and derivatives thereof, N-acetylglucosamine, flax extract, cinnamon extract, mulberry extract, scotch extract, breadfruit Extracts Examples of the extract include black beetle extract, nezushinosakamodoki extract, yusora extract, etsukinotosakamodoki extract, nankaitosakamodoki extract, himetosakamodoki extract, and the like.

(21) Intercellular adipogenesis promoter / intercellular lipid state improving agent Specifically, phospholipids (phosphatidylethanol, phosphatidylcholine, phosphatidyltriethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylglycerol, phosphatidylinositol, diacylphosphatidylcholine, Diacylphosphatidylethanolamine, diacylphosphatidylinositol, diacylphosphatidylserine, 1-cysteinylphosphatidic acid, 2-cysteinylphosphatidic acid, 1-glutathionylphosphatidic acid, 2-glutathionylphosphatidic acid, 1-azelaoylphosphatidic acid 2-Azela oil phosphatidic acid, 1-hydroxyacyl phosphatidic acid, 2-hydroxyacyl phosphatidic acid, ceramide, glucosi Ceramide, galactosylceramide, cerebroside, phosphatidylglucosylacylglycerol, N-oleoylsphingosine, N- (12-hydroxyoctadecanoyl) sphingosine, N- (16-hydroxyhexadecanoyl) sphingosine, N-salicyloylphytosphingosine, Sphingomyelin, soybean lecithin, egg yolk lecithin, etc.), sterins (cholesterol, dihydrocholesterol, cholesteryl stearate, cholesteryl hydroxystearate, macadamia nut oil fatty acid cholesteryl, β-sitosterol, stigmasterol, campesterol, ergosterol, 5-dihydro Ergosterol, phytosterol, 25-hydroxycholesterol, 26-hydroxycholesterol, 19-hydroxycholesterol 22-ketocholesteroloxime, 6-ketocholesterol and 7-ketocholesterol or their derivatives), N-acetylneuraminic acid (sialic acid), N-glucosolneuraminic acid, gangliosides (galaose, ganglytriaose, Ganglitetraose, globotetraose, neolactotetraose, neolactohexaose, neolactooctaose, etc.), oligosulfated hyaluronic acid, hydroxytamoxifen compounds, glyceroglycolipids, pentoxyferrin, 3-deazaadenosine, Carboxamide derivatives, inositol polyamines, sialic acid, triterpenic acid derivatives, lactose, lactosamine derivatives, sulfated chitin derivatives, albumin, ginseng extract, tochiban ginseng extract, sea cucumber extract, red lily extract Hakata lily extract, poppy extract, and the like.

(22) Keratolytic agent / stratum corneum exfoliation accelerator Specifically, tropolone and its derivatives, resorcin, lactic acid, urea, salicylic acid, guanidine, ethanolamine, kikarasuuri (Gurone) extract, fenugreek extract, wisteria bean (shado) Extract, lentil extract, chickpea extract, mungbean extract and the like.

(23) Plasminogen activator antagonist inhibitor Specific examples include rabbit daisy extract, canamgra extract, caladium extract, raspberry extract and the like.

(24) Maillard reaction inhibitors Specifically, aminoguanidine, flavanones (naringin, naringenin, naringin, naringenin, liquiritin, liquiritigenin, digallic acid, luteoic acid, ellagic acid, chlorogenic acid, glucogallin, tetralin, hamamelitannin Tannic acid, tannic acid, tannic acid, geraniin, gallic acid, galloyl gallic acid, ellagitannin, hexagalloyl glucose, heptagalloyl glucose, tetragalloyl glucose, trigalloyl glucose, pentagalloyl glucose, digalloyl quinic acid, trigalloyl kinin Acid), 2-hydroxyphenylalkylamine derivatives or salts thereof, phenylpropenoic acid derivatives (3- [2,3-bis (methoxymethoxy) phenyl] propenoic acid, 7- (4-hydroxy-3-methoxyphenyl) hepta- 2,4,6- Trienoic acid, 3- (3,5-dimethoxy-4-hydroxyphenyl) propenohydrazide, N'-isopropylidene-3- (2-methoxyphenyl) propenohydrazide, etc.), citric acid or a salt thereof, ginger (Ishizuchi) Root) extract, sandalwood extract, red-crowned wrinkle extract, persimmon (including salmon) extract, mulberry extract, Hypericum perforatum extract, camellia extract, garega extract, yaba santa extract, rosehip extract, asunaro extract, itadori extract, icha yak extract, kei Kanka extract, Birch extract, Hawthorn extract, Achillea millefolium extract, Cod extract, Dokudami extract, Tormentilla extract, Bakumondo extract, Hiba extract, Grape extract, Michiyanagi extract, Mukuroji extract, Karin extract, Mokka extract, Roman kami Reekisu, and the like.

(25) Testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promoter Specifically, γ-amino-β-hydroxybutyric acid esters (γ-amino-β-hydroxybutyric acid methyl ester, γ-amino) -β-hydroxybutyric acid ethyl ester, γ-amino-β-hydroxybutyric acid propyl ester, γ-amino-β-hydroxybutyric acid butyl ester, γ-amino-β-hydroxybutyric acid ethylhexyl ester, γ-amino-β-hydroxybutyric acid hexa Decyl ester, γ-amino-β-hydroxybutyric acid lauryl ester, γ-amino-β-hydroxybutyric acid stearyl ester, γ-amino-β-hydroxybutyric acid oleyl ester, γ-amino-β-hydroxybutyric acid benzyl ester, γ-amino -β-hydroxybutyric acid phenyl ester, γ-amino-β-hydroxybutyric acid ethyl glycol ester, γ-amino-β-hydroxy Acid sorbitol ester, γ-amino-β-hydroxybutyric acid polyoxyethylene glycol ester, γ-amino-β-hydroxybutyric acid glycerin ester, etc.), amine oxides (oleyl dimethylamine oxide, stearyl dimethylamine oxide, palmityl dimethylamine oxide) , Myristyl dimethylamine oxide, lauryl dimethylamine oxide, dimethyl lauryl ethoxyamine oxide, dihydroxyethyl lauryl amine oxide, coconut oil alkyl dimethylamine oxide, etc.), alkyl betaines (coconut oil fatty acid amidopropyl betaine, coconut oil alkyl betaine, lauryl dimethyl) Aminoacetic acid betaine, lauric acid amidopropyl betaine, lauryl hydroxysulfobetaine, 2-alkyl-N-carboxymethyl-N-hydroxy Ethyl imidazolinium betaine), pyrimidine N-oxide derivatives (2-amino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-6- (1-pyrrolidinyl) pyrimidine- 3-oxide, 2-amino-4-methyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-6- [1- (4-methylpiperazinyl)] pyrimidine-3-oxide, 2-amino-4- (1-hexahydroazepinyl) -6-methylpyrimidine-1-oxide, 2-amino-4-dimethylamino-6-methylpyrimidine-1-oxide, 2-amino-4-allylamino -6-methylpyrimidine-1-oxide, 2-amino-4-benzylamino-6-methylpyrimidine-1-oxide, 2-amino-4,5-methyl-6-piperidinopyrimidine-3-oxide, 2 -Amino-4-ethyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-5-nitro-6-piperidinopyrimidine-3-io Sid, 2,5-diamino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-5,6-bis (1-pyrodinyl) pyrimidine-3-oxide, 2-amino -4-methyl-5-piperidino-6- (1-pyrrolidinyl) pyrimidine-3-oxide, 2-methyl-4-amino-6-piperidinopyrimidine-3-oxide, 2-methyl-4-amino-5 -Bromo-6- (1-pyrosinyl) pyrimidine-3-oxide, 2-methyl-4-amino-5-nitro-6-piperidinopyrimidine-3-oxide, 2-methyl-4,5-diamino-6 -Piperidinopyrimidine-3-oxide, 2-methyl-4-amino-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-6-piperidinopyrimidine-3 -Oxide monohydrochloride, 2-acetylamino-4-methyl-6-piperidinopyrimidine-3-oxide, 2,4-diamino-6-phenoxypyrimidine-3-oxide, 2,4-diamino-6- ( 2,4-dichlorophenoxy ) Pyrimidine-3-oxide, 2,4-diamino-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitroso-6- (2,4-dichlorophenoxy) ) Pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2, 4-dichlorophenoxy) pyrimidine-3-oxide, 2,4,5-triamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-bromo-6- (2, 4-dichlorophenoxy) pyrimidine-3-oxide, etc.), p-menthane-3,8-diol, monoglyceryl-D-glucoside monotridecanoate, 1-oN-pentadecylglycero-D-glucoside, mono Glycerol sulfate such as pentadecanoic acid glyceride sulfate, monopentadecyl glyceryl ether sulfate, 1-o-hexade -2-o-methylglycerol, 1-o-octadecyl-2-o-methylglycerol, 1-o-oleyl-2-o-methylglycerol, acetylcarnitine or a salt thereof, geranylgeranylacetone, Hydroxamic acid derivative or its salt, gingerone glycoside, benzeneoxyacetic acid derivative ([5- [2- [1-phenyl-1- (3-pyridyl) methylideneaminooxy] ethyl] -7,8-dihydronaphthalene 1-yloxy] acetic acid, etc.), isorhamnetin-3-robinobioside, xanthone derivatives, proanthocyanidins (grape seed extract proanthocyanidins, apple-derived proanthocyanidins, pine-derived proanthocyanidins, purified procyanidin oligomers, procyanidin B-1, procyanidin B- 2, procyanidin B-3, procyanidin C-1, etc.), arakashi extract, angelica extract, apricot ( Jin) extract, Hong apricot extract, Ichiyakusou (one herb) extract, Enishida extract, psyllium (car forerunner, car forerunner) extract, Psyllium extract , Chrysanthemum extract, striped chrysanthemum extract, ginseng extract, cuttlefish extract, kukui nut extract, camphor tree extract, kubeba extract, buckthorn extract, snapper extract, snapdragon extract, snapdragon extract, kipi extract, citrus extract, cilantro extract, kobushi extract, Magnolia extract, honeysuckle extract, binankazura extract, pine bush extract, colombo extract, condurango extract, sasanqua extract, sweet potato extract, honeybee jujube ( (Jinjin) Extract, Sandskon (Yamadame) Extract, Potato Extract, Shishigashira Extract, Sanshishi Extract, Coriander Extract, Stevia Extract, Takatodai Extract, Tarayou (Ooba Fuyu Ao, Ichiha Tea, Bitter Tea, Tofu Tea) Extract, Taran Extract, Nigaki (Nagi) Extract, Nurde (Pyto) Extract, Hakama Labosi (Bone Disintegrating) Extract, Hamakokuren Extract, Smoke Squirrel Extract, Sphagoptera Extract, Hakakugusa (Sugar) Extract, Hyacinth Carrot Extract, Mangosteen Extract, Myouga Extract, Melaleuca Extract, Yachabushi (Yagar) Extract, Himeya Shabushi Extract, Ooyabaya Shabushi Extract, Yakuso Extract, Yamahanoki (Yamatake) Extract, Longan (Dragon Eye Meat) Extract, Locon (Yoshi, Sone) Extract , Logwood extract, lantana extract, etc. .

(26) Hair matrix growth inhibitor / hair growth inhibitor Specifically, phthalazinones, benzoxazinones, phosphonic acid derivatives, cyproterone, 5α-androstene-3α, 17β-diol, medroxyprogesterone, norethisterone, Examples include Mestanolone, Ichihatsu (primary) extract, Kashiwa extract, Kantou extract, Sanjiko extract, Shiramo extract, Sowjutsu extract, Hitobushi licorice extract, Fritillary extract, Iris japonica extract, Iris extract and Yoremok extract.

(27) Hair swelling / protecting agent Specific examples include ethanolamine, urea, guanidine, silicones, blueberry extract, mango extract, and the like.

(28) Odorous substance eliminating agent Specific examples include inondo extract, Elemi extract, danmar extract, vanilla bins extract, pine extract and the like.

  Specific examples of ingredients derived from plant-based materials used as additives include Aokazura (Seifu-to) extract, Aotenma extract, Akasuguri extract, Aquine (crust) extract, Aguay guassu extract, Abiul extract, Abiurana Extract, yellow sapote extract, ylang ylang extract, phalaenopsis extract, uba tea extract, suzuran extract, unboku extract, elderberry extract, sasayukiyuki extract, sasanoyuki extract, tossed cactus extract, ohia catechu extract, onoelan extract, cynomolgus (Kinshato) Extract, Karaya Extract, Garyu Extract, Kawaratake Extract, Candelilla Extract, Canna Extract, Kidachi Pepper Extract, Kimenkaku Extract, Cabbage Extract, Kiraja Saponaria Extract, Ginsekai Extract, Kimbusen Eki , Guapeba vermelha extract, kugenumaran extract, cousberry extract, cutiti river extract, curkrigo latifolia extract, black moth (rescue) extract, cucurian extract, sapotea mariyo extract, salmon berry extract, sarancito (sand indigo) (Sashimi) extract, Sancactus cactus extract, Sansakuyo Sou extract, Shunran extract, Shozukku extract, Shirobanatsuta extract, Cinconacill sylbra extract, Swimberry extract, Star apple extract, Sulgaran extract (Oran) extract, Red pine extract, Seiyo Cypress extract, scallop extract, mistletoe extract, sennin cactus extract, senboku extract, elephant shoot extract, prunus extract, some mono-potato extract, dark sea Cherry extract, Prickly pear extract, Choco nostay extract, Korean mugwort extract, Azalea extract, Azalea extract, Azalea extract (Duckweed) extract, Duberry extract, Clover extract, Tragacanth extract, Triacanthus extract, Nai Zeria berry extract, Rapeseed extract, Plover-dough extract, Pau doce extract, Hakukayumatou extract, Hakuru berry extract, Batata extract, Hamakakiran extract, Balata extract, Harcan orchid extract, Pecan nut extract, Dinosaur extract Extract, Brazilian carrot extract, Braignen extract, Frucereria extract, Blond psyllium extract, Hetsukaran extract, Henken extract, Berry extract, Persair extract, Pervianburg extract, Pele Kia Grandifolia extract, Boysenberry extract, Hosairan extract, Pouteria sapota extract, Pouteria rukuma extract, Hosobabarengiku extract, Whataberry berry extract, Masalan ubaba extract, Masala nuba de ceara extract, Masheira de Boyi extract , Matta Oryo Extract, Mulberry Extract, Green Zapote Extract, Murasaki Corn Extract, Megacansa Opuntica Extract, Mokukirin Extract, Momijidaio Extract, Morello Cherry Extract, Yakawa Murasaki Imo Extract, Cornflower Extract, Rurita Thistle Plant extracts such as Xinjiang Indigo Ginger Extract, Red Currant Extract, Red Pitaya Extract, Lemongrass Extract, Wax Palm Extract, Logan Berry Extract, etc. I can get lost.

  Specific examples of the ingredients derived from plant-based materials used as additives include Dunaliella genus Dunaliella extract, Chlorococcus chlorococcus extract, Quaternium genus Kuwanomimo extract, Volbox genus genus sunflower extract, Volbox genus Volbox extract, Palmera extract, Jupiter extract, Aomydra spp. Extract, Papilio spp. Extract, cassava extract, cicada extract, colecaete extract, cicada extract, duckweed extract, crayfish Green extract such as Loa extract, Kunshomo extract, Sumiremo violet extract, Hosimidro extract, Fuchinashimidro extract Iso Grape Extract, Isogawara Isogawara Extract, Kurogashira Gunsen Kurogashira Extract, Kashirazaki Kashirazaki Extract, Muchimo Muchimo Extract, Muchimo Hiramchimo Extract, Muchimo Keribergusa Extract, Amygusa Sakibiro Amiji Extract, Common Sasa Common Gusa Extract, Jigamigusa Genus Jigmyusa extract, Nami-makura genus Hirami-makura extract, Someraceae genus Someraceae extract, Navaimo genus Navarimo extract, Chasomen moth Chasomen extract, Nagamatsu sp. Nagamatsu sp. Rabbit extract, Rhizoma spp. Weeping Manori Extract, Weeping Crab Extract, Fritillaria Fistula Extract, Cultivation Crane Extract, Frog Brown algae extract such as genus Chlome extract, Chrysanthemum genus Chrysanthemum extract, Nerecomb genus Nerecomb extract, Spirella spp. Extract, Amanori Tasa Extract, Amanori Firitasa Extract, Amanori Benitasa Extract, Rhodocorton Mirnoveni Extract, Kona Hada Hyakona Hada Extract, Kona Hada Yokore Kona Hada Extract, Kona Hada Ao Naha Hada Extract, Rhizobium Genus Thrips Gassilori extract, pine genus pine extract, Nisefusanori genus Fusanoori extract, Sodegarami genus Sodegarami extract, Hirohata Tadaki genus Hirohata Mitaki extract, Amanita Nambugusa extract, Tengususa spp. Pseudomonas spp. Crabnote extract, Coral spider coral extract, Centipede spruce cadaver extract, Centipede spruce extract, Centacum spp. Denori genus centipede extract, centipede genus vine extract, centipede genus fudarak extract, genus genus marbahudarak extract, cypress genus cypress extract, arabe genus madder extract, quince genus chabo kintoki extract, kinto genus kintoki extract Pine extract, Kintoki-Hitomatsu extract, Kintoki-Bushiki-toki-toki extract, Kintoki-tsunomu-kade extract, Kintoki-toga-kinki-toki extract, Kintoki-suji-kadeki extract, Kakera-to-spotted oakkin-toki extract, Nagaobane-genus Nagaobane extract, Kalekigusa-kalekigusa extract, Kinuhada Genus Kinu Hada extract, Tsukasanoori Enashikarimenia extract, Tsukasanoori Otsukasanori extract, Tsukasanoori Hanagatakarimenia extract, Ho Genus honoo extract, genus genus genus genus extract, genus genus genus Usugineu extract, genus genus genus genus urchinum extract, venus nago genus venus nago extract, skunk genus suskake beni extract, okaramusa genus genus extract, isomocca genus isomokka extract, pheasant genus pheasant extract Isodantsu Isodantsu Extract, Atsubanori Atsubanori Extract, Ogonori Mizoogonori Extract, Ogonori Beniogonori Extract, Ogonori Ukureshinori Extract, Ogonori Murasakibibanori Extract, Ogonori Sinkaibanori Extract, Ogonori Extract , Ogonori genus Katagogonori extract, Ogonori genus Ryukyu Ogonori extract, Ogonori genus Ogonori extract, Ogonori genus Ituginu extract, Ogonori genus Yumi Ganoderma extract, Ogonori genus Kubileogonori extract, Ronus spruce genus extract, Ronus spp. Scorpion genus extract, Rhizoma genus extract, Sedum genus extract, Scots squirrel extract, Scutella genus extract, Scutella genus extract, Scutella genus extract, Scutella genus extract, Fukutsunagi extract Hanaedae extract, Hirata goat Hirata goat extract, Dulse scorpion extract, Dulse anadalus extract, Webagus webag Extract , Konohanori extract, Suzushironori extract, Usbeni spp.usbeni extract, Hasujiginu spp. Heius vanori genus Suusus banori extract, Haius banori genus Hyus banori extract, Usubanorimodoki genus Usubanorimodoki extract, Ayanishiki genus Ayanishiki extract, Goatium Aeginu Extract, Dadia Enasidadia Extract, Shimadadia Isohagi Extract, Shimadadia Shimadadia Extract, Dajimodaki Dajimomodoki Extract, Makuri Makuri Extract, Hanegusa Hanagusa Extract, Hanegusa Kehanegusa Extract, Kozanemo Kozaemone Kozaemone Cozanemo sp. Red algae, such as Isobasho genus Isobasho extract, Ideukogome genus Yukogome extract, Ochimozuki Okichimozuku extract, Chisujinori genus Chisujinori extract Extracts, Shajikumo Extract, Shirahamamo Extract, Hoshitsurimo Hoshitsurimo Extract, Rikunotumnusu Extract, Flasmocha spp. It is done.

  Specific examples of ingredients derived from animal materials used as active ingredients or additives include chicken crown extract, cow, pig or human placenta extract, pig or cow stomach, duodenum, intestine, spleen extract or degradation products thereof. , Bovine or porcine brain tissue extract, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolysate, elastin, elastin hydrolysate, water-soluble elastin derivative, keratin and its degradation product or derivatives thereof, silk Proteins and degradation products thereof or derivatives thereof, porcine or bovine blood cell protein degradation products (globin peptides), cattle or pig hemoglobin degradation products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and degradation thereof Products or derivatives thereof, skim milk powder and decomposition products thereof or derivatives thereof, lactoferrin or decomposition products thereof, chicken egg formation , Fish hydrolyzate, nucleic acid-related substance (ribonucleic acid, deoxyribonucleic acid), and the like.

  Specific examples of components derived from microbial materials used as active ingredients or additives include yeast metabolites, yeast extract extracts, bacterial metabolites, bacterial extract extracts, metabolites such as molds or mushrooms, actinomycetes metabolites , Extracts such as fungi or mushrooms, actinomycetes extract, natto metabolite, natto extract, rice fermented extract, rice bran (red rice bran, white birch) fermented extract, euglena extract or decomposed product thereof or water-soluble derivatives thereof, raw milk Or, a lactic acid fermented product of skim milk powder, trehalose or a derivative thereof, etc.

  In addition, as a plant, animal, or microbial material, any site, cell, tissue, organ, metabolite, etc. derived from a transgenic body or a cell fusion can be used. Furthermore, it is obtained by culturing cells of any site, cell, tissue, organ, etc., for example, cultured cells derived from each tissue (cultures derived from animals such as fibroblasts, Langerhans cells, macrophages, epidermal cells, hepatocytes, etc.) Cell etc.), undifferentiated cell group, cell group in the middle of differentiation, and their metabolites can also be used.

  Specific examples of components of natural raw materials used as active ingredients or additives include seawater such as deep seawater, for example, sea salt, seawater dried product, Dead Sea, Atlantic Ocean or Pacific Ocean. Sodium, magnesium chloride, potassium chloride, etc.), sea mud or mud (fungo), for example, sea mud or mud in various places such as Italian fungo, German fungo, Eifelfango, Freiburg fungo (containing components: silicon dioxide, titanium dioxide, Aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water) , Saintoku stone, natural smectite, bentonite, hectorite, etc. It is.

  Extracts derived from plant-based raw materials, animal-based raw materials, microbial-based raw materials, and other natural product raw materials used as active ingredients or additives are processed in a conventional manner according to the product type and form to be added (for example, pulverized) , Milling, washing, extraction, degradation, fermentation or metabolic conversion by microorganisms, fractionation, purification, pressing, filtration, drying, powdering, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. It is only necessary to select and use any of various materials.

  The solvent used for extraction may be selected in consideration of the intended purpose and type of the product to be provided or the processing to be performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isopropanol are used. Lower alcohol such as butanol or hydrous lower alcohol, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1, 3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, 1,2-hexanediol, 1,5-hexanediol, 1,6-hexanediol, pentylene glycol, hexylene glycol, Polyhydric alcohols such as glycerin and polyethylene glycol (molecular weight 100 to 100,000) or hydrous polyhydric alcohols, alcohols T, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, carbon tetrachloride, phenol, toluene, and other organic solvents, and acids prepared with appropriate normality (hydrochloric acid, sulfuric acid, It is desirable to use one or a mixture of two or more selected from nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.). However, when it is not preferable to contain a solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it can be used alone or in any mixture with water. What was extracted may be sufficient.

  Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. The temperature of the solvent can be arbitrarily set in the range of −4 ° C. to 100 ° C., but is preferably around 10 to 40 ° C. from the viewpoint of the stability of the components contained in the raw material. Further, the weight ratio of the solvent to the raw material can be arbitrarily set within the range of, for example, raw material: solvent 4: 1 to 1: 100, and a weight ratio of 1: 1 to 1:10 is particularly preferable.

  Decomposition mainly includes acid decomposition, alkali decomposition, enzyme decomposition, and high-temperature and high-pressure decomposition. In the decomposition with an acid, for example, it is preferable to use an inorganic acid or an organic acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, oxalic acid, hydrogen bromide, perchloric acid, and periodic acid. In the decomposition by alkali, for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, barium hydroxide, sodium carbonate, ammonium carbonate, calcium carbonate, magnesium hydroxide, sodium silicate, etc. are preferably used. In the decomposition with acid or alkali, the concentration, reaction time, reaction temperature, and the like can be arbitrarily set for the target raw material. In the enzymatic degradation, it is preferable to use an enzyme having a function of degrading proteins, polysaccharides, lipids or complexes thereof having an important function particularly with respect to cell structure, tissue structure, etc., for example, aminopeptidase, dipeptidase, dipeptide Peptidyl peptidase, tripeptidyl peptidase, carboxypeptidase, serine protease, trypsin, chymotrypsin, cysteine protease, thiol protease, papain, aspartate endopeptidase, metalloendopeptidase, promeline, thermolysin, pronase, pepsin, rennin, Proteolytic enzymes (proteases) such as pancreatin, chymopapain, ficin, collagenase, elastase, amylase, takaamylase, cellulase, hemicellular Polysaccharide-degrading enzymes such as zectin, pectinase, polygalacturonase, dextranase, and pralanase, chicken egg white lysozyme, human lysozyme, papaya lysozyme, cabra lysozyme, barley lysozyme, zymolyce, lysozyme chloride, glucanase, gluco Examples include cell wall lytic enzymes such as uronidase, chitinase, and kilosanase. In the case of using an enzyme, the concentration, reaction time, reaction temperature, pH of the solution, and the like can be arbitrarily set, but it is particularly preferable to set the optimum value for the enzyme used.

Fermentation or metabolic conversion by microorganisms can be carried out by inoculating and growing at least one or more microorganisms on a raw material used as a substrate. Inoculation of microorganisms to the substrate can be done by adding microorganisms directly into the substrate, or by adsorbing them on a carrier such as alginic acid, polyvinyl, gelatin, etc., for example, in the form of fine beads composed of microorganisms and carrier. Further, it can be used by being fixed to the tube wall of the bioreactor. Fermentation or metabolic conversion by microorganisms is not particularly defined as a microorganism to be used, but can generally be defined as microorganisms other than pathogenic microorganisms that exhibit significant toxicity to living bodies. Examples of microorganisms to be used include microorganisms classified into yeasts: Aciculoconidium, Actonia, Aessosporon, Ambrosiozyma, Amphierna, Anthomyces, Apiotrichum, Arthroascus, Arxula, Ascotrichosporon, Ashbia, Ashbya Genus, Asporomyces, Atelosaccharomyces, Azymocandida, Azymohansenula, Azymomyces, Azymoprocandida, Babjevia, Ballistosporomyces, Basidiotrichosporon, Bensingtonia, Blastobotrysbota, Blastodlastrzo Brettanomyces (Brettanomyces bruxellensis, Brettanomyces anomalus, etc.), Bullera, Bulleromyces, Candida (Candida albicans, Candida amylolenta, Candida anomala, Candida boidinii, Candida entomaea, Candida etchellsment, Candida etchellsii, Candida etchellsment Candida intermedia, Candida krusei, Candida lactosa, Candida lipolytica, Candida mogii, Candida parapsilosis, Candida sake, Candida tropicalis, Candida versatilis, Candida vulgaris, etc., Castellania, Chlamydozyma, Chromotorula, Citeromyces, Cladosporium, Clavispora, Crebrothecium, delbaryo, genus halotolerans, Debaryomyces hansenii, etc.), Debaryozyma, Dekkera, Dekkeromyces, Dematium, Dipodascus, Eeniella, Enantiothamnus, Endoblastoderma, Endoblastomyces, Endomyces, Endomycopsis, Endyllium, Etelexium, Entelex Genus, Eutorula, Eutorulopsis, Fabospora, Fellomyces, Fermentotrichon, Filobasidium, Galactomyces, Geotrichoides, Geotrichum, Guilliermondella, Hanseniaspora, Hansenulaan, Hansenulaan, Hansenulaan, Hansenula Hansenula wickerhamii), Hypomyces, Issatchenkia, Kloeckera (Kloeckera brevis, Klo) eckera fluorescens, Kloeckera japonica, etc.), Kloeckeraspora, Kluyveromyces (Kluyveromyces bulgaricus, Kluyveromyces marxianus, Kluyveromyces thermotolerans, Genus Kockovaella, Kurtzmanomyces, Leucosporidium, Leucosporidium, Leucosporidium Monospora, Monosporella, Mrakia, Myceloblastanon, Mycocandida, Mycoderma, Mycotorula, Mycokluyveria, Mycotoruloides, Myxozyma, Nadsonia, Nectaromyces, Nematospora, Otosporomyces, Ogataea, Ogataea , Oosporidium genus, Pachysolen genus, Parasaccharomyces genus, Paratorulopsis genus, Parendomyces genus, Petasosospora genus, Pichia genus (genus Pichia amylophila, Pichia farinosa, Pichia guilliermondii, Pichia membranifaciens, Pichia mogirum, genus Proticcpo Proteomyces, Pseudohansenula, Pseudomonilia, Pseudomycoderma, Pseudosaccharomyces , Pseudozyma spp, Rhodomyces genus, Rhodosporidium genus, Rhodotorula genus, Saccharomyces genus (Saccharomyces aceti, Saccharomyces cerasi, Saccharomyces cerevisiae, Saccharomyces exiguus, Saccharomyces unisporus, Saccharomyces fibuligera etc.), Saccharomycodes genus, Saccharomycopsis spp, Saturnispora genus, Schizoblastosporion spp, Schizosaccharomyces spp , Schwanniomyces genus, Selenotila genus, Selenozyma genus, Smithiozyma genus, Sporidiobolus sp Genus, Vanrija, Waltomyces, Willia, Willopsis, Wingea, Xanthophyllomyces, Yamadazyma, Zendera, Zygofabospora, Zygopichia, Zygohansenula, Zygorenospora, Zygosaccharomyces, Zygosaccharomyces, etc. . Microorganisms classified as bacteria include Acetobacter genus (Acetobacter aceti, etc.), Achromobacter genus, Acidianus genus, Acidobacterium genus, Acidithiobacillus genus, Acrocarpospora genus, Actinoalloteichus genus, Actinocorallia genus, Actinokineospora genus, Actinomadspura genus, Actinomadspura Actinosynnema genus, Aerococcus genus, Aeromicrobium genus, Agrobacterium genus, Agromyces genus, Ahrensia genus, Alcaligenes genus, Alicyclobacillus genus, Alloiococcus spp. , Aureobacterium genus, Azotobacter genus, Bacillus genus (Bacillus brevis, Bacillus subtilis etc.), Bacteroides genus, Beneckea genus, Bifidobacterium genus (Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis etc.), Brachybacterium genus, Brevicillus, Brevundimonas, Burkholderia, Carnobacterium, Catellat genus ospora, Cellulomonas, Chainia, Chromobacterium, Chryseobacterium, Citrobacter, Clavibacter, Corynebacterium, Couchioplanes, Cryptosporangium, Curtobacterium, Dactylosporangium, Deinococcus, Delftia, Dermatia, Dermatia , Elytrosporangium, Enterobacter, Erwinia, Escherichia, Eubacterium, Excellospora, Exiguobacterium, Faenia, Flammeovirga, Flavobacterium, Flexibacter, Geodermatophilus, Globicatella, Gluconacetobaceto, Gluconacetobacter Genus, Gordonia, Halobacterium, Halococcus, Herbidospora, Hydrogenophilus, Hyphomicrobium, Hyphomonas, Intrasporangium, Janibacter, Jonesia, Kibdelosporangium, Kineopocusato, Kitasposatos, Kitasposatos, Kitasposatos Klebsiella, Kocuria, Kurthia, Lactobacillus (Lactobacillus rimae, Lactobacillus dive rgens, Lactobacillus carnis, Lactobacillus piscicola, Lactobacillus acidophilus, Lactobacillus amylophilus, Lactobacillus animalis, Lactobacillus brevis, Lactobacillus casei, Lactobacillus curvatus, Lactobacillus bulgaricus, Lactobacillus delbrueckii, Lactobacillus fermentum, Lactobacillus fructivorans, Lactobacillus fructosus, Lactobacillus helveticus, Lactobacillus hilgardii, Lactobacillus homohiochii, Lactobacillus kefiri, Lactobacillus malefermentans, Lactobacillus murinus, Lactobacillus paracasei, Lactobacillus paracasei subsp. tolerans, Lactobacillus parakefiri, Lactobacillus pentosus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus sakei, Lactobacillus confusus, Lactobacillus viridescens, Lactobacillus johnsonii, Lactobacillus viscosus, Lactobacillus bunchneri , Lactobacillus fermentatae, Lactobacillus acidophil-aerogenes, Lactobacillus leichmannii, Lactobacillus gasseri, Lactobacillus bifidus, Lactobaci llus jugurt, Lactobacillus caucasicus, Lactobacillus arabinosus, Lactobacillus kunkeei, Lactobacillus nagelii, Lactobacillus fornicalis, Lactobacillus pentoaceticus, Lactobacillus xylosus, Lactobacillus minutus, etc.), Leuconostoc genus (Leuconostoc lactis, Leuconostoc dextranicum, Leuconostoc mesenteroides, Leuconostoc oenos, Leuconostoc paramesenteroides, Leuconostoc cremoris, Leuconostoc citrovorum etc.), Listonella genus, Lucibacterium genus, Luteococcus genus, Magnetospirillum genus, Marinilabilia genus, Marinospirillum spp. Genus, Nocardioides, Nonmuraea, Nonomuria, Oceanospirillum, Ochrobactrum, Oerskovia, Oligella, Paenibacillus, Pediococcus ui, etc.), Pedobacter, Peptococcus, Peptostreptococcus, Pilimelia, Pimelobacter, Planobispora, Planococcus, Planomonospora, Prevotella, Propionibacterium, Proteus, Protomonas, Pseudomonas, Genus, Rathayibacter, Rhizobium, Rhizomonas, Rhodobacter, Rhodococcus, Rhodopseudomonas, Rhodospirillum, Rothia, Rubrobacter, Ruegeria, Saccharomonospora, Siracrothinas, Sporolactobacillus spp., Stenotrophomonas spp., Streptoalloteichus spp., Streptococcus spp. (Streptococcus durans, Streptococcus faecalis, Streptococcus faecium, Streptococcus bovis, Streptococcus equinus, Streptococcus mutans, Streptococcus salivarius, Streptococcus thermophilus, Streptococcus agalactiae, Streptococcus mitis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus lactis , Streptococcus dysgalactiae, Streptococcus sanguis, Streptococcus acidominimus, Streptococcus avium, Streptococcus uberis, Streptococcus cremoris, Streptococcus diacetilactis, etc. Genus, Thiobacillus genus, Thiomonas genus, Thiosphaera genus, Weissella genus, Xanthobacter genus, Xanthomonas genus, Zymomonas genus and the like. Microorganisms classified as ascomycetes, basidiomycetes or incomplete fungi other than yeast include Allomyces, Amoebidium, Amorphotheca, Arthroderma, Ascoidea, Ascobolus, Ascodesmis, Aspergillus, Aureobasidium, Botryosphaeria , Botryotinia, Brachybasidium, Byssochlamys, Capnodium, Ceratocystis, Ceratomyces, Chaetomium, Chrysella, Chrysocelia, Chytridium, Claviceps, Cochliobolus, Coemansia, Genus Genus, Cyttaria, Dasyspora, Derchslera, Dirchmyces, Dichomyces, Dothidea, Endogone, Entomophthora, Emericella, Eupenicillium, Eurotium, Exobasidium, Gibberella, Glomus, Graphiola, Gymnoascus, Harpella Helicomyces, Hellvella, Hemicarpenteles, Hyphochytrium, Hypocrea, Laboulbenia, Labyrinthula, Leptosphaeria, Leptosphaerulina, Lophodermium, Melanotaenium , Microascus, Microstroma, Medeolaria, Melampsora, Melampsporella, Morchella, Monascus, Monilinia, Monoblephalis, Mycospharella, Nannizzia, Nectria, Neolecta, Neurospora, Nodulosphaeria, Olizadium, Genus, Penicillium, Perenospora, Pestalotiopsis, Phomopsis, Phragmi
diella genus, Pneumocystis genus, Preussia genus, Pleospora genus, Puccinia genus, Pythium genus, Ravenelia genus, Rickia genus, Rhinocladiella genus, Rhizidiomyces genus, Rhizoctonia spp. Sordaria genus, Sporidiobolus genus, Stibella genus, Stigmatomyces genus, Sydowiella genus, Talaromayces genus, Taphrina genus, Thraustochytrium genus, Tolyposporium genus, Trichoglossum genus, Trichoma genus, Ustilago genus, Verticillium genus, Xylaria genus and the like.

  In fermentation or metabolic conversion by microorganisms, in addition to various raw materials such as plant-based materials, animal-based materials, and other natural product-based materials, the growth and metabolism of microorganisms are regulated or activated, and special biosynthesis or degradation pathways are induced. In order to achieve this, various compounds can be added to the raw material. For example, as a carbon source, a sugar or ethane such as glucose, fructose, galactose, sucrose, maltose, mannose, lactose, glycerol, starch, etc. , Hydrocarbons such as methane, propane, butane, formic acid, acetic acid, propionic acid, lauric acid, palmitic acid, fatty acids such as oleic acid, linoleic acid, linolenic acid, etc., nitrogen sources such as ammonium sulfate, ammonium hydrochloride, ammonium phosphate, etc. Ammonium salt, urea, uric acid, amino acids, etc. Vitamins and compounds that contain potassium, calcium, magnesium, sodium, sulfur, phosphorus, chlorine, etc., as well as iron, copper, zinc, cobalt, nickel, boron, manganese, molybdenum, tin, selenium, silicon It is possible to further add compounds contained in the composition such as arsenic, vanadium, chromium and fluorine. In addition, the optimum temperature, oxygen supply amount, pH, pressure, etc. that affect the growth and metabolic activity of various microorganisms can be arbitrarily set according to the characteristics inherent to various microorganisms. Can be arbitrarily set in the range of 10 to 50 ° C., and the pH can be arbitrarily set in the range of 1 to 14.

  In fractionation or purification, generally known techniques can be used as appropriate. In addition to solvent extraction, for example, liquid chromatography (ion exchange chromatography, ion exclusion chromatography, affinity chromatography, gel filtration chromatography, size exclusion chromatography, etc.). Chromatography, hydrophilic adsorption chromatography, hydrophobic adsorption chromatography, ligand exchange chromatography, etc.), dialysis with semipermeable membrane, crystallization and recrystallization of components, filter paper, membrane filter, ultra filter, Examples thereof include density gradient separation methods such as filtration using activated carbon and filter aid, centrifugal separation, and fractional precipitation methods, density gradient sedimentation equilibrium methods, and the like.

In the present invention, as other compounds used as additives, specifically, silicic anhydride, magnesium silicate, talc, kaolin, bentonite, hectorite, natural or synthetic smectite, stevensite, mica, mica titanium, bismuth oxychloride , Zirconium oxide, Magnesium oxide, Zinc oxide, Titanium oxide, Calcium carbonate, Magnesium carbonate, Yellow iron oxide, Bengala, Black iron oxide, Gunjo, Chromium oxide, Chromium hydroxide, Carbon black, Calamine and other inorganic pigments, Peroxide Hydrogen water, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium peroxide tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate, silica Acid Inorganic reducing agents such as lithium hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide , Redox agents such as thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate), 5-aminoorthocresol, 2-amino-4 -Nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene hydrochloride -2,5-diamine, nitroparaphenylenediamine hydrochloride , Paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxy Naphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium picrate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, meta Phenylenediamine, 5-aminoorcresol sulfate , 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, sulfuric acid Nitroparaphenylenediamine, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine, catechol, diphenylamine, α- Natural dyes such as naphthol, hydroquinone, phloroglucin, sodium 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonate, hematein, musk, civet, castrium, ambergris Physical Flavor, Anise Essential Oil, Angelica Essential Oil, Ylang Ylang Essential Oil, Iris Essential Oil, Fennel Essential Oil, Orange Essential Oil, Kananga Essential Oil, Caraway Essential Oil, Cardamom Essential Oil, Guayak Wood Essential Oil, Cumin Essential Oil, Black Letter Essential Oil, Cinnamon Essential Oil, Cinnamon Essential Oil, Geranium Essential Oil, Copaiba balsam essential oil, coriander essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil, dairy perfume essential oil, tuberose essential oil, clove essential oil, orange flower essential oil, winter green Essential Oil, Truval Sam Essential Oil, Baturi Essential Oil, Rose Essential Oil, Palmarosa Essential Oil, Persimmon Essential Oil, Hiba Essential Oil, Sandalwood Essential Oil, Petit Glen Essential Oil, Bay Essential Oil, Vetiva Essential Oil, Bergamot Essential Oil, Peruvian Balsam Essential Oil, Boadrose Essential Oil, Haruka Essential Oil, Mandarin Essential , Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaroe essential oil, Lemongrass essential oil, Lemon essential oil, Rosemary essential oil, Japanese mint mint essential oil and other plant flavors, other synthetic flavors, 5-amino-o-cresol, o -Aminophenol, m-aminophenol, p-aminophenol, 2,6-diaminopyridine, 5- (2-hydroxylethylamino) -2-methylphenol, N, N-bis (β-hydroxyl) -p-phenylene Diamine / sulfate, N, N-bis (2-hydroxyethyl) -p-phenylenediamine, p-nitro-o-phenylenediamine, p-phenylenediamine, m-phenylenediamine, N-phenyl-p-phenylenediamine, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene / sodium sulfate, toluene-2,5-diamine, 2- (2'-hydroxyethylamino) -5-aminotoluene, N, N-bis ( β-hydroxyl) -p-fu Nylenediamine, N, N-bis (2-hydroxyethyl) -p-phenylenediamine sulfate, 5-amino-o-cresol sulfate, p-aminophenol sulfate, o-chloro-p-phenylenediamine Sulfate, 2- (2'-hydroxyethylamino) -5-aminotoluene, sulfate, 4,4'-diaminodiphenylamine, sulfate, p-methylaminophenol, sulfate, p-phenylenediamine, sulfate, m-phenylenediamine sulfate, toluene-2,5-diamine sulfate, 2,4-diaminophenoxyethanol hydrochloride, toluene-2,5-diamine hydrochloride, m-phenylenediamine hydrochloride, 2, 4-diaminophenol hydrochloride, 3,3'-iminodiphenol, p-phenylenediamine hydrochloride, N-phenyl-p-phenylenediamine hydrochloride, N-phenyl-p-phenylenediamine acetate 1 , 5-dihydroxynaphthalene, Ruen-3,4-diamine, p-methylaminophenol, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, o-aminophenol sulfate, 2,4 -Diaminophenol sulfate, m-aminophenol sulfate, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, nitro-p-phenylenediamine Hydrochloride, 1,4-diaminoanthraquinone, nitro-p-phenylenediamine, picramic acid, sodium picramate, 2-amino-5-nitrophenol / sulfate, resorcinol, nitro-p-phenylenediamine / sulfate, p- Nitro-o-phenylenediamine sulfate, p-nitro-m-phenylenediamine sulfate, red No. 2, red No. 3, red No. 102, red No. 104 (1), red No. 105 (1), Red No. 106, Red No. 201, Color 227, Red 230 (1), Red 230 (2), Red 231, Red 232, Red 401, Red 502, Red 503, Red 504, Red 506, Yellow 4 No. 5, Yellow No. 5, Yellow No. 202 (1), Yellow No. 202 (2), Yellow No. 203, Yellow No. 402, Yellow No. 403 (1), Yellow No. 406, Yellow No. 407, Orange No. 205, Orange No. 207, Orange No. 402, Green No. 3, Green No. 204, Green No. 205, Green No. 401, Green No. 402, Brown No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 202, Blue 203 No., Blue No. 205, Black No. 401, Red Cabbage Dye, Red Rice Dye, Akane Dye, Anato Dye, Ikumi Dye, Turmeric Dye, Enju Dye, Krill Dye, Amber Dye, Caramel, Gold, Silver, Gardenia Dye, Corn Dye , Onion pigment, onion Dyes, spirulina dyes, buckwheat whole plant dyes, cherry dyes, laver dyes, hibiscus dyes, grape juice dyes, marigold dyes, purple potato dyes, purple yam dyes, lacquer dyes, rutin dyes and coloring agents, avocado oil, Almond oil, fennel oil, sesame oil, olive oil, orange oil, orange raffer oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber nut oil, safflower oil, shea fat, liquid shea fat, large Bean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, coconut oil, beef tallow, lard Oils such as hydrogenated products (hardened oil, etc.), beeswax, carnauba wax, whale wax, lanolin, liquid lano Phosphorus, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax, waxes such as squalene, squalane, pristane, mineral oils such as liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcristan wax, lauric acid, myristin Acids, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, natural fatty acids such as 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, capron Acids, fatty acids such as 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid, isopentanoic acid and the like, synthetic fatty acids, ethanol, isopyropanol, lauryl alcohol, cetanol, Natural alcohols such as teal alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, alcohols such as synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, 2-octyldodecanol, isopropyl myristate, isopropyl palmitate, Butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyl decyl dimethyloctanoate, diisobutyl adipate, 2-hexyldecyl adipate, diheptyl undecyl adipate, monoisostearate Acid N-alkyl glycol, isocetyl isostearate, trimethylolpropane triisostearate, diethylhexyl Ethylene glycol sanate, neopentyl glycol diethylhexanoate, cetyl 2-ethylhexanoate, trimethylolpropane triethylhexanoate, pentaerythritol tetraethylhexanoate, cetyl octanoate, octyldodecyl gum, cetyl lactate, myristyl lactate, diethyl phthalate, Esters such as dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate , Metal soaps such as zinc laurate and zinc undecylenate, anionic surfactants (alkyl carboxylates, alkyls Honates, alkyl sulfates, alkyl phosphates), alkyl sulfates (sodium lauryl sulfate, potassium lauryl sulfate, triethanolamine lauryl sulfate, ammonium lauryl sulfate, sodium cetyl sulfate, sodium stearyl sulfate, etc.), secondary Alcohol sulfate ester salt, alkyl ether sulfate ester salt (for example, polyoxyethylene lauryl sulfate triethanolamine, sodium polyoxyethylene lauryl sulfate), alkyl and alkyl allyl ether sulfate ester salt (N-acylmethylalanine salt, N-acyl) Glutamate, N-acylmethyl taurate, N-acyl isethionate, N-acyl glycine, alkyl phosphate, alkyl ether carboxylate, alkyl sulfonate, alkyl Killsulfosuccinate, sodium polyoxyethylene lauryl ether sulfate, polyoxyethylene lauryl ether sulfate triethanolamine, polyoxyethylene lauryl ether ammonium sulfate, polyoxyethylene alkyl ether sodium sulfate, polyoxyethylene alkyl ether sulfate triethanolamine, polyoxy Ethylene alkyl ether sulfate diethanolamine, polyoxyethylene alkyl ether ammonium sulfate, etc.), higher fatty acid alkylolamide sulfate ester salt, higher fatty acid ester sulfate ester salt (hardened coconut oil fatty acid sodium glyceryl sulfate, etc.), polyoxyethylene alkyl ether carboxylic acid, poly Oxyethylene alkyl allyl ether carboxylates, sulfated oils such as sulfated castor oil, Dialkyl or alkenyl phosphate salts, polyoxyethylene mono or dialkyl or and alkenyl
Acid ester salt (sodium monolauryl phosphate, sodium isostearyl phosphate, arginine 2-hexyldecyl phosphate, potassium 2-heptylundecyl phosphate, polyoxyethylene (4-10) sodium lauryl ether phosphate, sodium monocetyl phosphate Arginine monomyristyl phosphate, sodium monooleyl phosphate, polyoxyethylene (2-10) potassium lauryl ether, sodium dioctyl phosphate, etc.), polyoxyethylene alkyl ether phosphate ester salt (polyoxyethylene lauryl ether) Phosphoric acid, polyoxyethylene oleyl ether phosphoric acid, polyoxyethylene cetyl ether phosphoric acid, polyoxyethylene stearyl ether phosphoric acid, polyoxyethylene alkyl ether phosphoric acid, poly Xyethylene alkylphenyl ether phosphate, etc.), sulfonates of higher fatty acid amides or sulfonates of higher fatty acid esters (α-olefin sulfonate, N-myristoyl-N-methyltaurine sodium, coconut oil fatty acid methyltaurine sodium, Sodium lauroylmethyl taurate, etc.), alkylbenzene sulfonate (dodecylbenzenesulfonic acid, monoethanolamine dodecylbenzenesulfonate, diethanolamine dodecylbenzenesulfonate, triethanolamine dodecylbenzenesulfonate, sodium dodecylbenzenesulfonate, etc.), sulfosuccinate (Sodium diethylhexyl sulfosuccinate, sodium sulfosuccinate, disodium lauryl sulfosuccinate, polyoxyethylene sulfosuccinate Disodium acid, disodium lauryl polyoxyethylene sulfosuccinate, disodium polyoxyethylene lauroyl ethanolamide ester sulfosuccinate, disodium undecylenoylamide ethylsulfosuccinate, monolauroyl monoethanolamide sodium polyoxyethylene sulfosuccinate, lauryl polypropylene glycol Sodium sulfosuccinate, etc.), N-acyl sarcosine salts (such as sodium lauroyl sarcosine, palmitoyl sarcosine sodium), condensates of higher fatty acids and amino acids (N-acyl glutamate, sodium N-stearoyl glutamate, potassium N-palmitoyl glutamate, N- Lauroyl-L-glutamate sodium, N-stearoyl-L-glutamate disodium, -Sodium myristoyl-L-glutamate, sodium myristoyl methyl taurate, sodium palmitoyl methyl taurine, sodium stearoyl methyl taurine, N-palmitoyl-β-alanine arginine, N-palmitoyl aspartate ditriethanolamine, etc.), oleate, suaraic acid Anionic surfactants such as fatty acid soaps such as salts, laurates and palmitates (examples of anionic surfactants include alkali metal salts such as sodium salts and potassium salts, monoethanolamine salts and diethanolamine salts) , Quaternary ammonium salts (alkyltrimethylammonium chloride, cetyl chloride, etc.), organic ammonium salts such as triethanolamine salt, L-lysine salt, L-arginine salt and the like, and ammonium salts. Ammonium, cetyl ammonium bromide, lauryl ammonium chloride, lauryl ammonium bromide, stearyl ammonium chloride, stearyl ammonium bromide, cetyl dimethyl ammonium chloride, cetyl dimethyl ammonium bromide, lauryl dimethyl ammonium chloride, stearyl dimethyl ammonium chloride, lauryl trimethyl ammonium chloride , Lauryl trimethyl ammonium bromide, stearyl dimethyl cetyl ditallow dimethyl ammonium chloride, dicetyl ammonium chloride, dicetyl ammonium bromide, dilauryl ammonium chloride, dilauryl ammonium bromide, distearyl ammonium chloride, distearyl ammonium bromide, chloride Dicetylmethylammonium, dicetylmethylammonium bromide, dilaurylmethylan chloride Nium, dilaurylmethylammonium bromide, distearylmethylammonium chloride, distearylmethylammonium bromide, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, lauryltrimethylammonium bromide, Dialkyldimethylammonium chloride, dicetyldimethylammonium chloride, distearyldimethylammonium chloride, dicocoyldimethylammonium chloride, myristyldimethylbenzylammonium chloride, stearyldimethylbenzylammonium chloride, ethyl lanolin sulfate fatty acid aminopropylethyldimethylammonium chloride, cetyltrimethylammonium chloride, Stearyltrimethylammonium chloride, Behenyltrimethylammonium chloride, behenyldimethylhydroxyethylammonium chloride, stearyldimethylbenzylammonium chloride, distearyldimethylammonium chloride, distearoylethylhydroxyethylmonium metasulfate, dicocoylethylhydroxyethylmonium metasulfate, dipalmitoylethylhydroxyethylmonium metasulfate , And cetyltriethylammonium methylsulfate, alkyltrimethylammonium chloride, alkyldimethylbenzylammonium chloride, dialkyldimethylammonium chloride, alkyltrimethylammonium bromide, alkylpentaethoxyammonium chloride, ditallowdimethylammonium chloride, ditallowdimethylammonium methylsulfate , Ammonium ditallow dipropyl phosphate, ditallow dimethyl ammonium nitrate, di (coconut alkyl) dimethyl ammonium chloride, di (coconut alkyl) dimethyl ammonium bromide, coconut ammonium chloride, stearamide propyl chloride PG-dimonium phosphate, steer Luamidopropylethyldimonium esosulphate, stearamidepropyldimethyl (myristyl acetate) ammonium chloride, stearamidepropyldimethylcetearylammonium tosylate, stearamidepropyldimethylammonium chloride, stearamidepropyldimethylammonium lactate, ethyl sulfate Lanolin fatty acid aminopropylethyldimethylammonium, cationized cellulose, acyl diethylaminoethyl acetate , Acyldimethylaminopropylamide, polyoxyethylene fatty acid amide, myristyldimethylamine oxide, N-lauryldimethylaminoacetic acid betaine, N-myristyldimethylaminoacetic acid betaine, N-stearyldimethylaminoacetic acid betaine, etc.), bis fatty acid ester salt ( Hydroxypropyl-bis-lauric acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-myristic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-palmitic acid amidopropyl-N, N- Dimethylammonium chloride, hydroxypropyl-bis-stearic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-behenic acid Midopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-oleic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-isostearic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis -Palm fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-tallow fatty acid amidopropyl-N, N-dimethylammonium chloride, Hydroxypropyl-bis-lauric acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-myristic acid amidoethyl-N N-diethylammonium chloride, hydroxypropyl-bis-palmitic acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-stearic acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-behenic acid amidoethyl- N, N-diethylammonium chloride, hydroxypropyl-bis-oleic acid amidoethyl ammonium chloride, hydroxypropyl-bis-isostearic acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidoethyl-N, N- Diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidoethyl-N, N-diethylammonium chloride, hydro Cypropyl-bis-tallow fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-lauric acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-myristic amidopropyl-N, N-diethylammonium Chloride, hydroxypropyl-bis-palmitate amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-amidopropyl stearate-N, N-diethylammonium chloride, hydroxypropyl-bis-behenate amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-oleic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis- Sostearic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidopropyl-N, N-diethylammonium chloride, Hydroxypropyl-bis-tallow fatty acid amidopropyl-N, N-diethylammonium chloride, etc.), stearamidepropyl PG-dimonium chloride phosphate, behenamidopropyl PG dimonium chloride, stearamidepropylethyldimonium ethosulphate, stear Luamidopropyldimethyl (myristyl acetate) ammonium chloride, stearamidepropyldimethylcetearylammonium tosylate, stearamidepropyldi Cationic surfactants such as methylammonium chloride and stearamidepropyldimethylammonium lactate, glycerin fatty acid esters (glyceryl monoundecylenate, glyceryl diundecylenate, glyceryl monomyristate, glyceryl dimyristate, glyceryl monopalmitate, diester Glyceryl palmitate, glyceryl monostearate, glyceryl distearate, glyceryl monooleate, mono-cotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, glyceryl monostearate, α, α'-glycolic acid pyroglutamate, monostearate Acid glycerin malic acid, etc.), polyglycerin fatty acid ester (diglyceryl monomyristic acid, diglyceryl dimyristic acid, trimyristic acid) Glyceryl, diglyceryl monopalmitate, diglyceryl dipalmitate, diglyceryl tripalmitate, diglyceryl monostearate, diglyceryl distearate, diglyceryl tristearate, diglyceryl monooleate, diglyceryl dioleate, triolein Diglyceryl acid, tetraglyceryl monopalmitate, tetraglyceryl dipalmitate, tetraglyceryl tripalmitate, tetraglyceryl tetrapalmitate, tetraglyceryl pentapalmitate, tetraglyceryl monostearate, tetraglyceryl distearate, tetraglyceryl tristearate , Tetraglyceryl tetrastearate, tetraglyceryl pentastearate, tetraglyceryl monooleate, tetraoleic acid tetra Riseriru trioleate tetraglyceryl, tetraoleate tetraglyceryl, penta oleate tetraglyceryl monopalmitate hexaglyceryl dipalmitate hexaglyceryl, hexaglyceryl tripalmitate, Tetoraparumichin acid Hekisaguri
Seryl, hexaglyceryl pentapalmitate, hexaglyceryl monostearate, hexaglyceryl distearate, hexaglyceryl tristearate, hexaglyceryl tetrastearate, hexaglyceryl pentastearate, hexaglyceryl monooleate, hexaglyceryl dioleate, triolein Hexaglyceryl acid, hexaglyceryl tetraoleate, hexaglyceryl pentaoleate, decaglyceryl monopalmitate, decaglyceryl dipalmitate, decaglyceryl tripalmitate, decaglyceryl tetrapalmitate, decaglyceryl pentapalmitate, decaglyceryl hexapalmitate Glyceryl, decaglyceryl heptapalmitate, decaglyceryl octapalmitate, decagli nonapalmitate Ril, decaglyceryl decapalmitate, decaglyceryl monostearate, decaglyceryl distearate, decaglyceryl tristearate, decaglyceryl tetrastearate, decaglyceryl pentastearate, decaglyceryl hexastearate, decaglyceryl heptearate, octa Decaglyceryl stearate, decaglyceryl nonastearate, decaglyceryl decastearate, decaglyceryl monooleate, decaglyceryl dioleate, decaglyceryl trioleate, decaglyceryl tetraoleate, decaglyceryl pentaoleate, decaglyceryl hexaoleate Glyceryl, decaglyceryl heptaoleate, decaglyceryl octaoleate, decaglyceryl nonaoleate, decagreate decag Seryl, monohydroxystearic acid decaglyceryl, dihydroxystearic acid decaglyceryl, trihydroxystearic acid decaglyceryl, tetrahydroxystearic acid decaglyceryl, pentahydroxystearic acid decaglyceryl, hexahydroxystearic acid decaglyceryl, heptahydroxystearic acid decaglyceryl, Decaglyceryl octahydroxystearate, decaglyceryl nonahydroxystearate, decaglyceryl decahydroxystearate, hexaglyceryl polyricinoleate, decaglyceryl polyricinoleate, polyoxyethylene glyceryl monostearate, polyoxyethylene glyceryl distearate, monoolein Acid polyoxyethylene glycerin, monomyristic acid polyoxyethylene Lenglycerin, etc.), polyoxyethylene glycerin fatty acid ester (polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate, etc.), sorbitan fatty acid ester (sorbitan monolaurate, monoolein) Sorbitan acid, sorbitan sesquioleate, sorbitan trioleate, sorbitan monopalmitate, sorbitan monostearate, sorbitan distearate, sorbitan dioleate, sorbitan monopalmitate, sorbitan tristearate, sorbitan trioleate, penta-2- Diglycerol sorbitan ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate, polyoxy monooleate Tylene sorbitan, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan trioleate, polyoxyethylene sorbitan pentaoleate, etc., propylene glycol fatty acid ester ( Propylene glycol monooctanoate, propylene glycol monodecanoate, propylene glycol monostearate, etc.), sucrose fatty acid ester (monolauric acid sucrose ester, dilauric acid sucrose ester, monopalmitic acid sucrose ester, dipalmitic acid sucrose ester, Monostearic acid sucrose ester, distearic acid sucrose ester, etc.), dextrin fatty acid ester (such as dextrin palmitate), Zushi oil fatty acid alkanolamide, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid Monoisostearic acid diester, polyoxyethylene hydrogenated castor oil maleic acid, polyoxyethylene alkyl ether (alkyl polyglucoside, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene behenyl ether, polyoxyethylene oleyl ether, polyoxy Ethylene lauryl ether, polyoxyethylene-2-octyldecyl ether, polyoxyethylene cholestanol ether, etc.), polyoxye Tylene alkyl phenyl ether (polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), polyoxyethylene fatty acid ester (polyethylene glycol monooleate, polyethylene glycol monostearate, polyethylene glycol monolaurate, etc.), lanolin derivatives (poly Oxyethylene lanolin, polyoxyethylene lanolin alcohol, polyoxyethylene sorbitol lanolin, etc.), POE / POP-alkyl ether (POE / POP-cetyl ether, POE / POP-2-decyltetradecyl ether, POE / POP-monobutyl ether), POE / POP-hydrogenated lanolin, POE / POP-glycerin ether, Tetronic, etc.), alkanolamide (coconut oil fat) Nonionic surfactants such as diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc., betaine-type amphoteric surfactants (2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethyl) Betaine aminoacetate, undecylcarboxymethoxyethylcarboxymethylimidazolinium betaine sodium, undecylhydroxyethylimidazolinium betaine sodium, undecyl-N-hydroxyethyl-N-carboxymethylimidazolinium betaine, alkyldiaminoethylglycine hydrochloride solution, Stearyl dihydroxyethyl betaine, stearyl dimethylaminoacetic acid betaine, stearyl dimethyl betaine sodium solution, coconut oil alkyl-N-carboxyl Ethyl-N-hydroxyethylimidazolinium betaine sodium, coconut oil alkylbetaine, coconut oil alkyldimethylaminoacetic acid betaine, coconut oil fatty acid amidopropyl betaine, coconut oil fatty acid-N-carboxymethoxyethyl-N-carboxyethylimidazolinium betaine Sodium, N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, N-cocoyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, lauryldimethylaminoacetic acid hydroxysulfobetaine, coconut oil alkyldimethyl Aminoacetate hydroxysulfobetaine, laurylaminopropionate triethanolamine, β-laurylaminopropionate sodium, laurate amide Dimethylaminoacetic acid betaine, lauric acid amidopropyl dimethylaminoacetic acid hydroxysulfobetaine, coconut oil fatty acid amidopropyl dimethylaminoacetic acid hydroxysulfobetaine, palm oil fatty acid amidopropyldimethylaminoacetic acid hydroxysulfobetaine, coconut oil fatty acid amidopropyl dimethylaminoacetic acid betaine, Palm oil fatty acid amidopropyldimethylaminoacetic acid betaine, lauryl N-carboxymethoxyethyl-N-carboxymethylimidazolinium disodium dodecanoyl sarcosine, lauryl diaminoethylglycine sodium, lauric acid amidopropyl betaine solution, lauryl sulfobetaine, lauryl hydroxysulfo Betaine, 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazoli Umbetaine, Cocodimethylcarboxymethylbetaine, Lauryldimethylcarboxymethylbetaine, Lauryldimethylalphacarboxyethylbetaine, Cetyldimethylcarboxymethylbetaine, Cetyldimethylbetaine, Laurylbis- (2-hydroxyethyl) carboxymethylbetaine, Stearylbis- (2-hydroxy Propyl) carboxymethylbetaine, oleyldimethylgamma-carboxypropylbetaine, laurylbis- (2-hydroxypropyl) alpha-carboxyethylbetaine, cocodimethylsulfopropylbetaine, stearyldimethylsulfopropylbetaine, lauryldimethylsulfoethylbetaine, laurylbis- (2 -Hydroxyethyl) sulfopropylbetaine, Levon 2000 (Sanyo) Kasei), Anon BDF (Nippon Yushi), Lonzain-CS (Lonza), Miratine CBS (Milan), Anon BL (Nippon Yushi), Lonzain 12CS (Lonza), etc.), imidazolinium type amphoteric interface Activator (bis (stearyl-N-hydroxyethylimidazoline) chloroacetic acid complex, N-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-alkyl-N-carboxymethyl-N-hydroxyethylethylenediamine, Lauryl sulfate and salts thereof, coconut oil alkyl-N-carboxyethoxyethyl-N-carboxyethyl imidazolinium disodium hydroxide, coconut oil alkyl-N-carboxymethoxyethyl-N-carboxyethyl imidazolinium disodium hydroxide, Palm oil Rukyl-N-carboxymethoxyethyl-N-carboxyethylimidazolinium disodium lauryl sulfate, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2-cocoyl-2-imidazoli Nitrohydroxide-1-carboxyethyloxy disodium salt, ovazoline 662 (Toho Chemical Co., Ltd.), Swanol AM-101 (Nikko Chemicals Co., Ltd.), Anon GLM (Nippon Yushi Co., Ltd.), aminopropionic acid type amphoteric surfactants ( Alkylaminopropionic acid such as sodium dodecylaminopropionate, alkylaminodipropionic acid, etc.), sodium dodecylaminopropanesulfonate, N-higher alkylaspartic acid or a salt thereof, coamidopropyl chloride polyethylene glycol dimonio Amphoteric such as phosphoric acid, cocamidopropyl hydroxysultain, sodium lauroyl sarcosinate, alkylamine oxide (decylamine oxide, cocoamine oxide, myristoylamine oxide, palmitoylamine oxide, alkyldimethylamine oxide, alkylamidopropylamine oxide, etc.) Surfactant, natural surfactant (lecithin, sodium caseinate, sphingolipid, saponin, mannosyl polyhydric alcohol fatty acid ester, glucosyl polyhydric alcohol fatty acid ester, galactosyl polyhydric alcohol fatty acid ester, etc. Disaccharide polyhydric alcohol fatty acid ester, oligosaccharide polyhydric alcohol fatty acid ester, etc.) and amino acid surfactants (capric acid chloride, lauric acid chlora) Id, myristic acid chloride, palmitic acid chloride, stearic acid chloride, oleic acid chloride, behenic acid chloride, coconut oil fatty acid chloride and other fatty acid chlorides and glycine, sarcosine, β-alanine, N-methyl-β-alanine, taurine, N -Reaction products with amino acids in a broad sense such as methyl taurine), silicone surfactants (silicon KF-6011 (manufactured by Shin-Etsu Chemical Co., Ltd.), KF-6012 (manufactured by Shin-Etsu Chemical Co., Ltd.), KF-6013 (Shin-Etsu Chemical Co., Ltd.) KF-6015 (manufactured by Shin-Etsu Chemical Co., Ltd.), KF-6016 (manufactured by Shin-Etsu Chemical Co., Ltd.), KF-6017 (manufactured by Shin-Etsu Chemical Co., Ltd.), X-22-4991 (manufactured by Shin-Etsu Chemical Co., Ltd.), NUC silicon L7002 (manufactured by Nihon Unicar), SH-3772C (Toray Dow Corning Silico Polyoxyalkylene-modified organopolysiloxanes such as SH-3775C (manufactured by Dow Corning Toray Co., Ltd.), ABIL EM-90 (manufactured by Goldschmidt), ABIL B9806 (manufactured by Goldschmidt), Silicon KF-602
6 (manufactured by Shin-Etsu Chemical Co., Ltd.) etc., long chain alkyl-containing polyoxyalkylene-modified organopolysiloxane, etc.), polyether-modified silicone (polyoxyethylene / methylpolysiloxane copolymer, poly (oxyethylene / oxypropylene) methylpoly) Siloxane copolymer, etc.), oxazoline-modified organopolysiloxane, alkyl-modified organopolysiloxane, styryl ketone silicone derivatives, dimethylpolysiloxane, methylphenylpolysiloxane, epoxy-modified silicone, fluorine-modified silicone, alcohol-modified silicone, alkyl-modified silicone, alkoxy Modified silicone, amino-modified silicone, ammonium-modified polymeric silicone, organopolysiloxane, methylphenylpolysiloxane, polysiloxane, poly (N- Silalkyleneimine) modified silicone, dimethylpolysiloxane, methylphenylpolysiloxane, nitrogen-containing acrylic-silicone graft copolymer, decamethylcyclopentasiloxane, fluorine-substituted alkyl-modified silicone, organopolysiloxanylsilylalkyl-modified silicone, three Cyclic diterpenecarboxylic acid modified silicone, trifluoroalkyl modified silicone, divinylpolydimethylsiloxane, dihydrogenopolydimethylsiloxane, dihydrogenopolydimethylsiloxane divinylpolydimethylsiloxane polymer, trimethylsiloxysilicic acid, polyoxypropylene / methylpolysiloxane Copolymer, ethylpolysiloxane, ethylmethylpolysiloxane, ethylphenylpolysiloxane, octamethylcyclotetrasilane Xanthone, diorganopolysiloxane, octamethylcyclotetrasiloxane, tetramethyltetraphenyltetracyclosiloxane, polyether-modified polysiloxane, amino-modified polysiloxane, epoxy-modified polysiloxane, fluorine-modified polysiloxane, alcohol-modified polysiloxane, Alkyl-modified polysiloxane, dodecamethylcyclohexasiloxane, laurylmethicone copolyol, aminoethylaminopropylsiloxane / dimethylsiloxane copolymer, silicone compounds such as eugenol-modified silicone, selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione , Hair treatment agents such as biphenamine, thianthol, quinine hydrochloride, strong ammonia water, zein, shellac, carboxymethylcellulose or alkalis thereof Film forming agents such as metal salts, hydroxypropylcellulose or phthalated derivatives or succinylated derivatives thereof, hydroxypropylcellulose acetate or phthalated derivatives or succinylated derivatives thereof, copolymers of acrylic acid compounds and methacrylic acid compounds, etc. Can be mentioned.

  In addition, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, refreshing agents, stabilizers, emulsifiers, animal / plant proteins and their degradation products, animal / plant polysaccharides and their Degradation products, animal / plant glycoproteins and their degradation products, anti-inflammatory agents, antiallergic agents, wound treatment agents, foaming agents, thickeners, enzymes, purified water (electronic water, small clusters, etc.), deodorant / A deodorant etc. can be used in combination.

  Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

[Production Example 1] Nimbin production method Dried neem seeds (629 g) were crushed in a mortar and then defatted three times using n-Hexane. The degreased residue was further extracted 3 times with 2 L of methanol, and the solvent after the filtration was removed under reduced pressure to obtain a methanol extract (206 g). Subsequently, the methanol extract (205 g) was subjected to solvent fractionation with methylene chloride-water (1: 1 v / v) to obtain a methylene chloride fraction (36 g) and a water fraction (165 g).
The methylene chloride fraction (22 g) was fractionated by silica gel column chromatography (gel amount: 844 g). The eluent was n-hexane-ethyl acetate [1: 0 (2000 mL), 19: 1 (2000 mL), 9: 1 (2500 mL), 4: 1 (2000 mL), 7: 3 (3500 mL), 3: 2 ( 3000mL), 1: 1 (5500mL), 2: 3 (2000mL), 3: 7 (4000mL), 1: 4 (3500mL), 0: 1 (3500mL) v / v], and methanol (3000mL), 18 fractions (Fr.1 (0.0342g), Fr.2 (1.5173g), Fr.3 (0.4099g), Fr.4 (0.1688g), Fr.5 (0.2902g), Fr.6 (0.1941g) ), Fr.7 (0.5273g), Fr.8 (2.3710g), Fr.9 (1.6291g), Fr.10 (2.5473g), Fr.11 (1.1179g), Fr.12 (0.6571g), Fr.13 (0.2329g), Fr.14 (0.4521g), Fr.15 (1.1837g), Fr.16 (0.1483g), Fr.17 (2.7239g), Fr.18 (7.2787g)] I drew it.
Fr.11 (1.0860 g) of the methylene chloride fraction was reversed-phase HPLC (column: PEGASIL ODS-II, 10 mm I.D. × 250 mm, manufactured by Senshu Scientific Co., Ltd .; eluent: methanol-water = 7: 3, v / v; flow rate: 3.0 mL / min) to obtain a compound (22.6 mg, retention time 16.8 min).

[Test 1] Analysis of the compound obtained in Production Example 1 The MS spectrum and NMR spectrum of the compound obtained in Production Example 1 were measured. The compound was identified as Nimbin (C ₃₀ H ₃₆ O ₉ MW = 540.609) by comparing spectral data with the document “APJarvis et al., J. Chem. Ecol., 23, 2841-2860 (1997)”. The measurement results are shown below.

(1) MS spectrum:
ESI-MS m / z: 541 [M + H] ⁺ , 563 [M + Na] ⁺ , 579 [M + K] ⁺ .
(2) NMR spectrum:
1H-NMR (400 MHz, CDCl ₃ ) δ1.28 (3H, s, H ₃ -19), 1.35 (3H, s, H ₃ -30), 1.36 (3H, s, H ₃ -29), 1.67 ( 3H, s, H ₃ -18), 2.04 (3H, s, OAc), 3.65 (3H, s, H ₃ COOC-), 3.74 (3H, s, -COOC H ₃ ), 4.05 (1H, d, J = 3.2Hz, H-7), 5.21 (1H, dd, J = 2.9,12.3Hz, H-6), 5.56 (1H, m, H-15), 5.88 (1H, d, J = 10.0Hz, H -2), 6.34 (1H, m, H-22), 6.33 (1H, d, J = 10.0Hz, H-3), 7.23 (1H, t, J = 1.7Hz, H-23), 7.32 (1H , br.s, H-21).

[Test 2] Melanin production inhibition test
B16 melanoma cells are mouse-derived melanin producing cells, and a drug that suppresses the production of melanin in these cells can be expected to lighten the skin color, that is, to whiten.
(sample)
Using the compound obtained in Production Example 1, DMSO was used to adjust the concentration to 25, 2.5, 0.25, and 0.025 μg / mL, and the test was performed. For comparison, Arbutin was adjusted to 25, 2.5 μg / mL, and 0.5% DMSO was used as a blank.
(Test method)
B16 melanoma cells were cultured for 24 hours, and this culture medium was replaced with a culture medium to which a sample was added. At this time, purified water was added to the blank. After culturing for 3 days, the cells were treated with trypsin, heated and dissolved in a 1N-NaOH solution containing 10% DMSO, and the absorbance at 420 nm was measured to obtain the amount of melanin. At the same time, the number of cells was measured by the MTT reduction method (Tim Mosmann; Journal of Immunological Methods p55-63 (1983) reference), and it was confirmed that there was no difference in the number of viable cells between the blank group and the sample addition group. The results are shown in FIG.

(Test results)
As shown in FIG. 1, ninbin, which is a compound of the present invention, was found to have a strong melanin production inhibitory effect about 10 times or more than arbutin, and was confirmed to be useful as a whitening agent.

[Prescription Examples] Production of various whitening agents and whitening skin external preparations Various whitening agents and whitening skin external preparations according to the present invention were produced. Although the formulation example is shown below, this invention is not necessarily limited to these.

(Formulation example 1) Whitening milk mass%
1.Squalane 5.0
2.Olive oil 5.0
3. Jojoba oil 5.0
4.Cetyl alcohol 1.5
5. Glycerin monostearate 2.0
6.Polyoxyethylene (20) cetyl ether 3.0
7. Polyoxyethylene (20) soorbitan monooleate 2.0
8.1,3-Butylene glycol 1.0
9.Glycerin 2.0
10. Compound of Production Example 1 0.2
11. Preservative (paraoxybenzoic acid ester) appropriate amount
12.Perfume appropriate amount
13. Residue with 100 purified water

(Formulation example 2) Whitening milk mass%
1. Squalane 8.0
2. Jojoba oil 7.0
3. Maltose 3.0
4. Compound of Production Example 1 0.2
5. Ascorbic acid phosphate magnesium salt 1.0
6.Cetyl alcohol 1.5
7. Glycerin monostearate 2.0
8.Polyoxyethylene (20) cetyl ether 3.0
9.Polyoxyethylene (20) soorbitan monooleate 2.0
10.1,3-Butylene glycol 1.0
11.Glycerin 2.0
12. Preservative (paraoxybenzoic acid ester) appropriate amount
13. Residue with 100 purified water

(Formulation Example 3) Whitening cosmetic oil
1.liquid paraffin 30.0
2.Squalane 20.0
3.Olive oil 20.0
4.Isopropyl palmitate 10.0
5. Compound of Production Example 1 0.05
6.Olive oil 1.0
7. Shea fat 1.0
8.Butylhydroxyanisole 0.1
9.DL-α-tocopherol derivative 0.1
10.Preservative appropriate amount
11.Perfume appropriate amount
12.Residue with 100 purified water

(Formulation example 4) Whitening lotion
1.Glycerin 5.0
2.1,3-Butylene glycol 5.0
3.Polyoxyethylene sorbitan monolaurate (20E.O) 1.0
4.Ethanol 15.0
5. Compound of Production Example 1 0.3
6.Glucose 1.0
7.Fructose 1.0
8. Antibacterial / preservative appropriate amount
9.Perfume appropriate amount
10. Residue with 100 purified water

(Formulation example 5) Whitening lotion
1.Sorbit 2.0
2. POE (20) oleyl alcohol 1.0
3.Ethanol 15.0
4. Hibamata 50% 1,3-butylene glycol extract 2.0
5. Hibiscus 50% 1,3-butylene glycol extract 2.0
6. Green tea leaf or stem 50% 1,3-butylene glycol extract 1.0
7. Camelis leaf or bark 50% 1,3-butylene glycol extract 1.0
8.Allantoin 0.2
9.Astringent 0.2
10. Compound of Production Example 1 0.2
11.Suitable amount of antibacterial / preservative
12.Residue with 100 purified water

(Formulation Example 6) Two-layer whitening lotion
1. Squalane 8.0
2. POE sorbitan tetraoleate 0.3
3.Sorbit 1.0
4.Ethanol 15.0
5. Senkyu rhizome 30% ethanol extract 2.0
6. Sage whole plant 30% ethanol extract 2.0
7. Glaze rhizome and leaf 30% ethanol extract 1.0
8. Pomelo fruit 30% ethanol extract 1.0
9.Ascorbic acid 0.2
10.Astringent 0.1
11. Compound of Production Example 1 0.3
12.2-phenoxyethanol appropriate amount
13. Residue with 100 purified water

(Formulation example 7) Whitening lotion mass%
1.Glycerin 3.0
2.1,3-Butylene glycol 5.0
3.Ethanol 15.0
4.Iron oxide 0.2
5.Zinc oxide 0.5
6.Kaolin 2.0
7. Compound of Production Example 1 0.2
8. Trehalose 2.0
9.Dextrin 0.5
10. Chamomile flower 50% propylene glycol extract 2.0
11. Photosensitive elements 201 and 401
12.Perfume appropriate amount
13. Residue with 100 purified water

(Prescription Example 8) Whitening pack mass%
1.Polyvinyl alcohol 15.0
2.Carboxymethylcellulose sodium 5.0
3.Propylene glycol 3.0
4.Ethanol 10.0
5. Compound of Production Example 1 0.4
6. Isomaltitol 1.0
7.Paraoxybenzoic acid ester
8. Perfume appropriate amount
9. Residue with 100 purified water

(Prescription Example 9) Whitening pack
1.Glycerin 5.0
2.Propylene glycol 4.0
3.Polyvinyl alcohol 15.0
4.Ethanol 8.0
5.Polyoxyethylene glycol 1.0
6. Pantothenyl ethyl ether 1.0
7. Compound of Production Example 1 0.5
8.Paraoxybenzoic acid ester
9.Perfume appropriate amount
10. Residue with 100 purified water

(Prescription Example 10) Whitening Cream Mass%
1． Squalane 20.0
2． Beeslow 5.0
3． Refined jojoba oil 5.0
Four. Glycerol monostearate 2.0
Five. Sorbitan monostearate 2.0
6． Polyoxyethylene (20) sorbitan monostearate 2.0
7． Glycerin 5.0
8. Compound of Production Example 1 0.2
9． Residue with 100 purified water

(Prescription Example 11) Whitening Cream Mass%
1. Sarah Beeswax 11.0
2.liquid paraffin 22.0
3.Lanoline 10.0
4.Olive oil 5.0
5. Chamomile oil 5.0
6. Palm oil 5.0
7.Oat bark extract 2.0
8.Kakkon Extract 3.0
9. Compound of Production Example 1 0.4
10 pearl seed extract 2.0
11.Liquid shea fat 1.0
12.Preservative 0.1
13.Hydroxypropylcellulose 2.0
14. Residue with 100 purified water

(Formulation example 12) Whitening cream mass%
1.Stearic acid 2.0
2. Stearyl alcohol 7.0
3.Reduced lanolin 2.0
4.Squalane 5.0
5. Octyldodecanol 6.0
6. Polyoxyethylene cetyl ether (25E.O.) 3.0
7. Lipophilic glyceryl monostearate 2.0
8.Propylene glycol 5.0
9. Compound of Production Example 1 0.3
10.Preservative appropriate amount
11.Perfume appropriate amount
12.Residue with 100 purified water

(Prescription Example 13) Face-wash cream%
1.Myristic acid 25.0
2.Stearic acid 5.0
3. Tallow fatty acid 5.0
4.Propylene glycol 10.0
5.Potassium hydroxide 6.0
6. Palm oil fatty acid diethanolamide 6.0
7.Glucose 1.0
8. Maltose 1.0
9. Compound of Production Example 1 0.3
10.Dipotassium glycyrrhetinate 1.0
11. Preservative 0.1
12.Perfume appropriate amount
13. Residue with 100 purified water

(Prescription Example 14) Facial cleansing cream mass%
1.Stearic acid 10.0
2.palmitic acid 10.0
3.Myristic acid 12.0
4.Lauric acid 4.0
5.Oleyl alcohol 1.5
6. Lanolin derivative (EO adduct) 1.0
7.Glycerin 18.0
8.Potassium hydroxide 6.0
9. Compound of Production Example 1 0.3
10.potassium glycyrrhizinate 1.0
11. Preservative 0.1
12.Perfume appropriate amount
13. Residue with 100 purified water

(Prescription Example 15) Body soap mass%
1.Potassium laurate 15.0
2.Potassium myristate 5.0
3.Propylene glycol 5.0
4. Maltose 3.0
5. Compound of Production Example 1 0.2
6.Polyethylene powder 0.5
7.Hydroxypropyl chitosan solution 0.5
8.Amino acid mixture 0.5
9.Preservative appropriate amount
10.pH adjuster
11.Perfume appropriate amount
12.Residue with 100 purified water

(Prescription Example 16) Sunscreen Cosmetics Mass%
1.Oxybenzone 2.0
2.Octyl paramethoxycinnamate 5.0
3.Squalane 10.0
4.Vaseline 5.0
5. Stearyl alcohol 3.0
6.Stearic acid 3.0
7. Glyceryl monostearate 2.0
8.Polyethyl acrylate 1.0
9.1,3-Butylene glycol 6.0
10.Edetate disodium 0.1
11.Triethanolamine 1.0
12.Titanium dioxide 5.0
13. Compound of Production Example 1 0.3
14.Preservative appropriate amount
15.Perfume appropriate amount
16.Residue with 100 purified water

(Prescription Example 17) Sunscreen Cosmetics Mass%
1.liquid paraffin 70.0
2.Ethyl paraaminobenzoate 1.0
3.Tetrahydroxybenzophenone 1.0
4.Cetyl octanoate 25.0
5. Compound of Production Example 1 0.3
6.Butylhydroxytoluene
7.Perfume appropriate amount

(Prescription Example 18) Cream foundation mass%
1. Stearic acid 4.0
2.Glycerol monostearate3.0
3.Cetanol 1.5
4.Isopropyl myristate 7.0
5. Liquid paraffin 10.0
6. Sarah Beeswax 3.0
7.Triethanolamine 1.5
8.Glycerin 3.0
9. Bentonite 1.0
10.Titanium oxide 8.0
11.2,4-Dihydroxybenzophenone 8.0
12.Kaolin 3.0
13. Talc 3.0
14. Colored pigment (yellow iron oxide) 1.0
15. Compound of Production Example 1 0.2
16. Trehalose 0.5
17.2-phenoxyethanol appropriate amount
18.Perfume appropriate amount
19.Residue with 100 purified water

(Prescription Example 19) Bath agent for whitening purpose
1. Refined jojoba oil 5.0
2.Polyoxyethylene sorbitan monolaurate 20.0
3. Glycerol monostearate 5.0
4. Liquid paraffin 2.0
5.Lauric acid diethanolamide 3.0
6.Glycerin 5.0
7. Compound of Production Example 1 0.5
8. Residue with 100 purified water

(Prescription Example 20) Ointment Mass%
1. Compound of Example 1 0.8
2.l-Menthol 3.0
3.DL-Camphor 0.5
4.Propylene glycol 15.0
5.Carboxyvinyl polymer 1.0
6.Hydroxyethyl cellulose 0.1
7. Lauro Macrogol 1.5
8.Triethanolamine 0.7
9.Purified water 25.0
10. Remaining ethanol 100

(Prescription Example 21) Whitening coating preparation Impregnated gauze or liniment cloth with a prescription solution in which the compound of Production Example 1 and a moisturizer, anti-inflammatory agent, cell activator, antioxidant, etc. are mixed and attached to the wound . Further, an application method in which these are directly applied locally and coated with gauze or the like may be adopted.

It is a figure which shows the melanin production inhibitory effect of the ninbin which is an active ingredient of this invention.

Claims (4)

A whitening agent characterized by containing nimbin as an active ingredient. The whitening agent according to claim 1, which is a melanin production inhibitor. A skin whitening preparation for whitening comprising the whitening agent according to claim 1 or 2. A method for whitening the skin, which comprises applying a composition containing nimbin as an active ingredient to the skin.

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