JP4472399B2 - Novel 3-hydroxyanthranilic acid derivatives - Google Patents

Description

  The present invention relates to novel 3-hydroxyanthranilic acid derivatives and their industrial applications.

  Conventionally, an anti-oxidant component (antioxidant) is blended in cosmetics, pharmaceuticals, quasi-drugs, and foods in order to prevent deterioration of contained components due to oxidation and accompanying deterioration of the product itself. Moreover, in recent cosmetics and topical medicines, in addition to the purpose of preventing oxidation of the product itself, it is intended to prevent or improve damage and aging associated with oxidation of living tissues such as skin and vascular endothelium. As an antioxidant component. As an antioxidant component usually used, ascorbic acid such as ascorbic acid or a derivative thereof and a salt thereof can be given as a representative substance. Ascorbic acids have whitening effects such as tyrosinase activity inhibitory action and melanin production inhibitory action in addition to antioxidative action, and as an effective ingredient that can be accompanied by antioxidant and whitening action, especially cosmetics And has been used for topical medicine.

  As antioxidant components other than ascorbic acids, various components such as quinones, polyphenols, and plant extracts are known. One of the known components is hydroxyanthranilic acid (2-aminohydroxybenzoic acid). As for hydroxyanthranilic acid, antioxidative effect on fats and oils of a mixture of 5-hydroxyanthranilic acid and α-tocopherol (Non-patent Document 1), antioxidative action on oils and fats of 3-hydroxyanthranilic acid (Non-patent Document 2) In addition to reports on the antioxidant activity such as the action of α-tocopherol having an inhibitory action on peroxidation of low-density lipoprotein and plasma lipid of 3-hydroxyanthranilic acid (Non-patent Document 3), Further, Maillard reaction inhibitory action of 3-hydroxyanthranilic acid or its lower carboxylic acid ester (Patent Document 1), use of 3-hydroxyanthranilic acid as a color reducing agent (Patent Document 2), 3-hydroxyanthranilic acid dye preliminary substance (Patent Document 3), 3-hydroxyanthranilic acid mushroom tyrosinase enzymatic reaction Act to reduce the resulting lag time (Non-Patent Document 4) have been reported. From these reports, it can be said that hydroxyanthranilic acid, especially 3-hydroxyanthranilic acid is an active ingredient having high antioxidant effect and other effectiveness, and is highly useful in the cosmetics field, pharmaceutical field and food field. However, as a result of preliminary tests by the inventor on the use of 3-hydroxyanthranilic acid as an antioxidant component, (i) 3-hydroxyanthranilic acid showed an antioxidant effect in vitro, but In chemical tests, a clear antioxidant effect could not be confirmed. In addition, (ii) 3-hydroxyanthranilic acid is a highly polar compound, so when used on the skin, there is a problem that the permeability to the skin is low and the physiological activity of 3-hydroxyanthranilic acid is difficult to be expressed in vivo. is there. Furthermore, (iii) 3-hydroxyanthranilic acid itself was confirmed to be a very unstable substance at room temperature. Therefore, when using 3-hydroxyanthranilic acid industrially, particularly in the fields of cosmetics, pharmaceuticals and foods, it is necessary to solve the items (i) to (iii) obtained from the results of the preliminary test. is there.

Journal of Japanese Society of Food and Nutrition, 30 (5), 291-296, (1977) Journal of Japanese Society of Food and Nutrition, 32 (1), 41-46, (1979) Journal of Biological Chemistry, 271 (51), 32714-32721, (1996) Biochemica et Biophysica Acta, 1384,268-276, (1998) International Patent Publication WO91 / 11997 Japanese Patent Laid-Open No. 06-106844 JP 56-501244 A

  Therefore, as a problem to be solved, new utilization of 3-hydroxyanthranilic acid that exhibits an antioxidative action in a living body, is easily penetrated into living tissue, particularly skin, and can exhibit excellent stability. Development of the method.

  In order to solve the above problems, the present inventor has developed novel 3-hydroxyanthranilic acid derivatives or pharmacologically acceptable salts thereof, which have excellent antioxidant activity and high stability in cells. The present invention was found to have an excellent whitening effect, and the present invention was completed. As for 3-hydroxyanthranilic acid derivatives, 3-hydroxyanthranilic acid dioxygenase inhibitory action of 3-hydroxyanthranilic acid-substituted compounds (Non-patent Document 5) and 3-hydroxyanthranilic acid derivative inhibition of 3-hydroxyanthranilic acid oxygenase to date Action (Patent Document 4), 3-hydroxyanthranilate oxygenase inhibitory action of 3-hydroxyanthranilic acid chlorine adduct (Non-Patent Document 6), antitumor or antibacterial activity of 3-hydroxyanthranilic acid prolinal acetal (Patent Document 5) And the protease inhibitory action of the hydroxyanthranilic acid derivative (Patent Document 6), the 3-hydroxyanthranilic acid derivative or the pharmacologically acceptable salt thereof according to the present invention is different from the structural formula of the compound. To a novel compound.

European Journal of Medicinal Chemistry, 34 (9), 729-744, (1999) European Journal of Medicinal Chemistry, 25 (3), 267-270, (1990) Japanese Patent Laid-Open No. 06-510058 Japanese Unexamined Patent Publication No. 63-66161 JP-A-60-208951

  That is, the present invention provides novel 3-hydroxyanthranilic acid derivatives having excellent antioxidant action, whitening action and high temporal stability, or pharmacologically acceptable salts thereof, and their industrial application methods. To do.

  The novel 3-hydroxyanthranilic acid derivatives or pharmacologically acceptable salts thereof, which are the products of the present invention, have excellent antioxidant action, specifically, oxidative stress inhibitory action. It is possible to constitute an antioxidant. Moreover, the said compound has the outstanding whitening effect | action, the melanin production inhibitory effect or the pigmentation inhibitory effect in detail, It is possible to comprise the outstanding whitening agent by using these. The compound is used in a cosmetic composition, a pharmaceutical composition for external use or a food composition. Specifically, the compound is used as an antioxidant or a whitening agent in a cosmetic composition or a pharmaceutical composition for external use. And various skin disorders caused by excessive melanin production or accumulation (for example, skin darkening such as spots, buckwheat, sunburn, skin aging such as wrinkles, dullness, sagging skin, skin flexibility and elasticity etc.) ) Can be effectively prevented or improved. In addition, since the compound has an excellent antioxidant action and stability over time, it is intended to prevent long-term oxidation of the product itself and to provide excellent storage stability associated therewith. It is also included in the scope of the present invention to be blended and used as an antioxidant in foods or food compositions. In addition, the compound is highly lipophilic compared to 3-hydroxyanthranilic acid, which is a highly polar compound, and therefore has higher skin permeability than 3-hydroxyanthranilic acid. Can be expected.

  The 3-hydroxyanthranilic acid derivative used in the present invention is a compound represented by the following formulas (1) to (3).

［上記式(1)中のＲ^１は炭素数9〜23の直鎖状又は分枝状のアルキル基，アルケニル基又はアルキニル基を示す。］

［上記式(2)中のＲ^２〜Ｒ^４は互いに独立して水素原子又はメチル基を示す。］

［上記式(3)中のＲ^５〜Ｒ^７は互いに独立して水素原子又はメチル基を示す。］

[R ¹ in the above formula (1) represents a linear or branched alkyl group, alkenyl group or alkynyl group having 9 to 23 carbon atoms. ]

[R ^{2 to} R ⁴ in the above formula (2) each independently represent a hydrogen atom or a methyl group. ]

[R ^{5 to} R ⁷ in the above formula (3) each independently represent a hydrogen atom or a methyl group. ]

The linear or branched alkyl group for R ¹ in the formula (1) is an alkyl group having 9 to 23 carbon atoms, such as a nonyl group, an isononyl group, a 2,2-dimethylheptyl group, an ethylnonyl group, Butylnonyl group, hexylnonyl group, octylnonyl group, decanyl group, isodecanyl group, propyldecanyl group, pentyldecanyl group, heptyldecanyl group, nonyldecanyl group, undecanyl group, isoundecanyl group, ethylundecanyl group, butylundecanyl group Nyl, hexylundecanyl, octylundecanyl, decanylundecanyl, dodecanyl, isododecanyl, propyldodecanyl, pentyldecanyl, heptyldodecanyl, nonyldodecanyl, undecanyldodecane Nyl group, tridecanyl group, isotridecanyl group, ethyltridecanyl group, Tiltridecanyl, hexyltridecanyl, octyltridecanyl, decanyltridecanyl, tetradecanyl, isotetradecanyl, propyltetradecanyl, pentyltetradecanyl, heptyltetradecanyl, nonyl Tetradecanyl group, pentadecanyl group, isopentadecanyl group, ethylpentadecanyl group, butylpentadecanyl group, hexylpentadecanyl group, octylpentadecanyl group, hexadecanyl group, isohexadecanyl group, propylhexadecanyl group Nyl group, pentylhexadecanyl group, heptylhexadecanyl group, heptadecanyl group, isoheptadecanyl group, ethylheptadecanyl group, butylhexadecanyl group, hexylheptadecanyl group, octadecanyl group, isooctadecanyl group , Propyl octadecane Group, pentyloctadecanyl group, nonadecanyl group, isononadecanyl group, ethylnonadecanyl group, butylnonadecanyl group, icosanyl group, isoicosanyl group, propyl icosanyl group, henoicosanyl group, isohenicosanyl group, ethyl Examples include a heenicosanyl group, a docosanyl group, an isodocosanyl group, a tricosanyl group, and an isotricosanyl group. In addition, an alkyl group to which one or more hydroxyl groups such as hydroxytridecanyl group, hydroxypentadecanyl group, hydroxyheptadecanyl group, hydroxynonadecanyl group, hydroxyhenicosanyl group and the like are added is also within the range of the alkyl group. Is included.

The linear or branched alkenyl group for R ¹ in the formula (1) is an alkenyl group having 9 to 23 carbon atoms having at least one double bond, such as a nonenyl group, an isononenyl group, and an ethylnonenyl group. , Nonadienyl group, decenyl group, isodecenyl group, propyldecenyl group, decadienyl group, undecenyl group, isoundecenyl group, ethylundecenyl group, undecadienyl group, dodecenyl group, isododecenyl group, propyldodecenyl group, dodecadienyl group, tridecenyl group, Isotridecenyl group, ethyltridecenyl group, tridecadienyl group, tetradecenyl group, isotetradecenyl group, propyltetradecenyl group, tetradodecadienyl group, pentadecenyl group, isopentadecenyl group, ethylpentadecenyl group Group, pentadecadienyl group, hexade Nyl, isohexadecenyl, propylhexadecenyl, hexadecadienyl, heptadecenyl, isoheptadecenyl, ethylheptadecenyl, heptadecenyl, octadecenyl, iso Octadecenyl group, propyloctadecenyl group, octadecadienyl group, nonadecenyl group, isononadecenyl group, ethylnonadecenyl group, nonadecadienyl group, icocenyl group, isoicocenyl group, heicocosenyl group, isohenicocenyl group , Dococenyl group, docosadienyl group and the like.

The linear or branched alkynyl group represented by R ¹ in the formula (1) is an alkynyl group having 9 to 23 carbon atoms having at least one triple bond, and examples thereof include nonin-yl group and isononin-yl group. Group, decynyl group, isodecynyl group, decadinyl group, isodecadinyl group, tridecynyl group, isotridecinyl group, ethyltridecinyl group, tridecadiin group, tetradecynyl group, isotetradecinyl group, tetradecadiin group, pentadecynyl group, isopentadecynyl group , Ethylpentadecynyl group, hexadecynyl group, isohexadecynyl group, heptadecinyl group, isoheptadecynyl group, ethylheptadecynyl group, octadecynyl group, isooctadecynyl group, nonadecynyl group, isononadecynyl group, ethylnonadecynyl Group, eicosinyl group, isoeicosinyl group, Ikoshiniru group, iso Heng Lee stiffness group, Dokoshiniru group, Isodokoshiniru group, Torikoshiniru group, Isotorikoshiniru group and the like.

Specific examples of the 3-hydroxyanthranilic acid derivative represented by the formula (1) include 3-hydroxyanthranilic acid pelargonic acid ester, 3-hydroxyanthranilic acid isononanoic acid ester, 3-hydroxyanthranilic acid caprylic acid ester, 3- Hydroxy anthranilic acid capric acid ester, 3-hydroxy anthranilic acid neodecanoic acid ester, 3-hydroxy anthranilic acid undecanoic acid ester, 3-hydroxy anthranilic acid undecylenic acid ester, 3-hydroxy anthranilic acid lauric acid ester, 3-hydroxy anthranilic acid myristic acid ester, 3-hydroxy-anthranilic acid myristoleic acid ester, 3-hydroxy-anthranilic acid isopalmitic acid ester, 3-hydroxy-anthranilic acid palmitoleic acid ester, 3-hydroxy anthranilic Luric acid margaric acid ester, 3-hydroxyanthranilic acid stearic acid ester, 3-hydroxyanthranilic acid isostearic acid ester, 3-hydroxyanthranilic acid oleic acid ester, 3-hydroxyanthranilic acid linoleic acid ester, 3-hydroxyanthranilic acid linolenic acid ester , 3-hydroxyanthranilic acid linolenic acid ester, 3-hydroxyanthranilic acid arachinic acid ester, 3-hydroxyanthranilic acid behenic acid ester, 3-hydroxyanthranilic acid erucic acid ester and the like. Furthermore, from the viewpoint of the stability of the compound, the permeability to the skin, the production cost, etc., 3-hydroxyanthranilic acid myristic acid which is a linear or branched saturated alkyl group having 14 to 18 carbon atoms in particular. Esters, 3-hydroxyanthranilic acid palmitic acid ester, 3-hydroxyanthranilic acid stearic acid ester and 3-hydroxyanthranilic acid isostearic acid ester are preferred.

R ^{2 to} R ⁴ in the formula (2) each independently represent a hydrogen atom or a methyl group. For example, all groups of R ^{2 to} R ⁴ are hydrogen atoms, or any one of R ^{2 to} R ⁴ Whether only one group is a methyl group and the other group is a hydrogen atom, or only two groups of R ^{2 to} R ⁴ are a methyl group and the other group is a hydrogen atom, or R ^{2 to} R All groups of ⁴ are methyl groups and the like are arbitrarily selected. In addition, when the 3-hydroxyanthranilic acid derivative represented by the formula (2) has an asymmetric carbon, any of D-form, L-form or its racemate is included in the scope of the 3-hydroxyanthranilic acid derivative of the present invention. .

  Specific examples of the 3-hydroxyanthranilic acid derivative represented by the formula (2) include 3-hydroxyanthranilic acid-D-α-tocopherol ester, 3-hydroxyanthranilic acid-D-β-tocopherol ester, 3-hydroxy Anthranilic acid-D-γ-tocopherol ester, 3-hydroxyanthranilic acid-D-δ-tocopherol ester, 3-hydroxyanthranilic acid-L-α-tocopherol ester, 3-hydroxyanthranilic acid-L-β-tocopherol ester, 3 -Hydroxyanthranilic acid-L-γ-tocopherol ester, 3-hydroxyanthranilic acid-L-δ-tocopherol ester, 3-hydroxyanthranilic acid-DL-α-tocopherol ester, 3-hydroxyanthranilic acid-DL-β-tocopherol ester 3-hydroxyanthranilic acid-DL-γ-tocopherol ester, 3-hydro Shiantoraniru acid -DL-.delta.-tocopherol esters, and the like. Furthermore, from the viewpoint of the penetration of the compound into the skin and the production cost, 3-hydroxyanthranilic acid-DL-α-tocopherol ester, 3-hydroxyanthranilic acid-D-α-tocopherol ester or 3-hydroxyanthranilic acid is particularly preferred. -L-α-tocopherol ester is preferred.

R ^{5 to} R ⁷ in the formula (3) each independently represent a hydrogen atom or a methyl group. For example, all of R ^{5 to} R ⁷ are hydrogen atoms, or any one of R ^{5 to} R ⁷ . Whether only one group is a methyl group and the other group is a hydrogen atom, or only two groups of R ^{5 to} R ⁷ are a methyl group and the other group is a hydrogen atom, or R ^{5 to} R All the groups in ⁷ are methyl groups and the like are arbitrarily selected. Further, when the 3-hydroxyanthranilic acid derivative represented by the above formula (3) has an asymmetric carbon, any of D-form, L-form or its racemate is included in the scope of the 3-hydroxyanthranilic acid derivative of the present invention. .

  Specific examples of the 3-hydroxyanthranilic acid derivative represented by the formula (3) include 3-hydroxyanthranilic acid-D-α-tocotrienol ester, 3-hydroxyanthranilic acid-D-β-tocotrienol ester, 3-hydroxy Anthranilic acid-D-γ-tocotrienol ester, 3-hydroxyanthranilic acid-D-δ-tocotrienol ester, 3-hydroxyanthranilic acid-L-α-tocotrienol ester, 3-hydroxyanthranilic acid-L-β-tocotrienol ester, 3 -Hydroxyanthranilic acid-L-γ-tocotrienol ester, 3-hydroxyanthranilic acid-L-δ-tocotrienol ester, 3-hydroxyanthranilic acid-DL-α-tocotrienol ester, 3-hydroxyanthranilic acid-DL-β-tocotrienol ester , 3-hydroxyanthranilic acid-DL-γ-tocotrieno Glycol ester, 3-hydroxy-anthranilic acid -DL-.delta.-tocotrienol esters. Furthermore, from the viewpoint of the penetration of the compound into the skin and the production cost, 3-hydroxyanthranilic acid-DL-α-tocotrienol ester, 3-hydroxyanthranilic acid-D-α-tocotrienol ester or 3-hydroxyanthranilic acid is particularly preferred. -L-α-tocotrienol ester is preferred.

  The pharmacologically acceptable salts of the 3-hydroxyanthranilic acid derivative of the present invention include salts with inorganic bases, salts with organic bases, salts with inorganic acids, salts with organic acids, and basic or acidic salts. Examples include salts with amino acids. Specific examples of the salt with an inorganic base include sodium salt, potassium salt, calcium salt, magnesium salt, barium salt, lithium salt, and aluminum salt. Examples of the salt with an organic base include ammonium salt, trimethylamine salt, triethylamine salt, pyridine salt, picoline salt, ethanolamine salt, diethanolamine salt, triethanolamine salt, dichloroamineamine salt, and dibenzylethylenediamine salt. Examples of the salt with inorganic acid include hydrochloride, hydrofluoride, hydrobromide, nitrate, sulfate, phosphate, perchlorate, hydroiodide, and the like. As salts with organic acids, formate, acetate, trifluoroacetate, fumarate, oxalate, tartrate, maleate, citrate, succinate, malate, mandelate, Examples include ascorbate, lactate, gluconate, metasulfonate, toluenephosphonate, and benzenesulfonate. Examples of salts with basic or acidic amino acids include arginine, lysine, ornithine, aspartic acid, glutamic acid and the like.

  The 3-hydroxyanthranilic acid derivative of the present invention or a pharmacologically acceptable salt thereof is produced and prepared mainly using 3-hydroxyanthranilic acid as a starting material by a known organic synthesis method. As a method for producing the 3-hydroxyanthranilic acid derivative represented by the formula (1), for example, a target carbon chain fatty acid chloride and 3-hydroxyanthranilic acid are reacted in a pyridine solvent, and then purified by silica gel chromatography. The manufacturing method to do is mentioned. Further, as a method for producing the 3-hydroxyanthranilic acid derivative represented by the above formulas (2) and (3), for example, a method similar to the method for producing a compound described in JP-B-61-52151 can be selected. Specifically, tocopherol or tocotrienol and 3-hydroxyanthranilic acid are reacted in a dimethylformamide / pyridine solvent, and the desired 3-hydroxyanthranilic acid derivative is extracted and purified from the reaction solution by solvent extraction or chromatography. The production method and 3-hydroxyanthranyl hydrochloride were synthesized by reacting 3-hydroxyanthranilic acid with thionyl chloride in dimethylformamide solvent, and then 3-hydroxyanthranyl hydrochloride and tocopherol or tocotrienol in pyridine / benzene solvent. The reaction solution is subjected to solvent extraction or chromatography. Manufacturing method in which purified by I over and the like.

  In preparing an antioxidant or a whitening agent using the 3-hydroxyanthranilic acid derivative of the present invention or a pharmaceutically acceptable salt thereof, the oil-like or paste-like compound is used as it is as an antioxidant or In addition to being able to be used as a whitening agent, it can also be used as an antioxidant or whitening agent by appropriately dissolving or dispersing in water, an organic solvent or a mixture thereof. Furthermore, it can be mixed with excipients, thickeners, gelling agents, etc. and adjusted to fine powders, granules, pellets, gels, or viscous liquids and used as antioxidants or whitening agents It is.

  Using the 3-hydroxyanthranilic acid derivative of the present invention or a pharmacologically acceptable salt thereof, it is possible to constitute a cosmetic composition, an external pharmaceutical composition or a food composition. The dosage form of the cosmetic composition and the external medicine is arbitrary, and is in the form of a capsule, powder, granule, solid, liquid, gel, foam, emulsion, cream, ointment, sheet, mousse, It forms dosage forms such as powder dispersion, multilayer, and aerosol. Specifically, the product forms of the cosmetic composition include skin lotion, beauty liquid, whitening lotion, milk, whitening milk, cream, whitening cream, ointment, whitening ointment, lotion, whitening lotion, oil, pack, etc. Basic cosmetics, soaps, cleansing creams, cleansing lotions, cleansing milk, cleansing milk, facial cleansing cosmetics, shampoos, rinses, treatments, etc., hair creams, hair sprays, hair tonics, hair gels, hair lotions, Hair oil, hair essence, hair water, hair wax, hair foam, hair conditioner, hair restorer, hair nourishing agent, hair loss prevention agent, 1-part hair dye or 2-part hair dye, hair color etc., permanent wave Scalp or hair cosmetics, foundations such as permanent agents such as hair and hair straighteners and wave retention agents Makeup cosmetics such as white powder, funny, lipstick, blusher, eye shadow, eyeliner, mascara, eyebrows, eyelashes, cosmetics for finishing such as beauty nails, perfume, dentifrice, mouthwash, mouthwash, bath Agents and the like. Examples of the product form of the external pharmaceutical composition include solutions, creams, ointments and the like. Furthermore, as a special dosage form, a gel composition containing the compound is supported on a non-woven fabric such as polystyrene, and one or a plurality of layers are formed. Particularly, the compound is locally concentrated at a high concentration. It is suitable when applied for the purpose of high antioxidant action, whitening action, or penetration of the compound into the skin. The compounding amount of the compound in the cosmetic composition and the external pharmaceutical composition is generally used in a concentration range of 0.0001% by mass or more in the total amount of the composition, preferably 0.01 to 50.0% by mass. Particularly preferably, 0.1 to 20% by mass is effective from the viewpoint of expression of an effect such as an antioxidative action or a whitening action expected in constituting a cosmetic composition and an external pharmaceutical composition.

  In addition, the dosage form of the food composition is also arbitrary, such as ampoules, capsules, powders, granules, pills, tablets, solids, liquids, gels, bubbles, emulsions, creams, etc. Form a mold. Specifically, health foods with the above dosage forms, oral compositions such as gums, candy and tablets, processed fishery products such as kamaboko and chikuwa, livestock products such as sausages and ham, Western confectionery, Japanese confectionery Noodles, raw noodles, Chinese noodles, boiled noodles, buckwheat noodles, sauces, soy sauce, sauce, sugar, honey, powdered candy, syrups such as syrups, spices such as curry powder, mustard powder, pepper powder, jam, marmalade, Chocolate spreads, pickles, pickled vegetables, sprinkles, processed vegetables and fruits such as canned and bottled vegetables, dairy products such as cheese, butter and yogurt, processed cereal products, fermented foods, miso soup, soup, fruits Juices, vegetable juices, whey drinks, soft drinks, alcoholic beverages and the like can be mentioned. The compounding amount of the compound in the food composition is generally used in a concentration range of 0.0001% by mass or more in the total amount of the composition, preferably 1.0 to 80.0% by mass, particularly preferably 5.0. ˜50 mass% is effective in constituting a food composition.

  In addition to the cosmetic composition, the external pharmaceutical composition or the food composition, the application field of the 3-hydroxyanthranilic acid derivative of the present invention or a pharmacologically acceptable salt thereof includes oral or non-antioxidant as an antioxidant. Various pharmaceutical compositions such as oral drugs, quasi-drugs, insecticides and rodenticides, agricultural chemicals, paints and inks, film forming agents, hard surface cleaners such as glass, metal and wood, and detergents for textiles Use in the field.

  The cosmetic composition, external pharmaceutical composition or food composition of the present invention includes, in addition to the above-mentioned compounds that are essential components, a pigmentation inhibitor, a tyrosinase activity inhibitor, a melanocyte melanin production inhibitor, and a melanin that are exemplified below. Production promoter, moisturizer, cell activator / metabolic activator, antioxidant, active oxygen scavenger / radical production inhibitor, fat metabolism promoter, UV protection / UV absorption promoter, astringent, anti-inflammatory agent / Interleukin production inhibitor / anti-inflammatory agent, antiseborrheic agent, antibacterial agent / antiviral agent, blood flow promoter / vascular stimulant, antiandrogen agent, structural proteolytic enzyme (elastase, collagenase, keratin protease, serine protease, Integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, pro Activity inhibitors, structural protein synthesis promoters, mucopolysaccharides (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitors, mucopolysaccharide synthesis promoters, intercellular lipogenesis promoters / intercellular lipid status improvement Agent, keratolytic agent / stratum exfoliation promoter, plasminogen activator antagonist inhibitor, Maillard reaction inhibitor, testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promoter, hair matrix cell growth inhibitor / Used to form active ingredients such as hair growth inhibitors, hair swelling agents / hair protection agents, odorant elimination agents, and other cosmetic compositions, external pharmaceutical compositions, or food compositions. Ingredients such as extracts and metabolites derived from plant-based materials, animal-based materials, microbial-based materials, and other natural product materials, or various compounds can be arbitrarily selected and used as additives. Thus, it is possible to provide an excellent cosmetic composition, external pharmaceutical composition or food composition having various functions. The content in the preparation is not particularly specified, but a concentration range of 0.0001 to 50% by weight is generally used.

(1) Pigmentation inhibitor Specifically, p-aminobenzoic acid derivatives, salicylic acid derivatives, benzenesulfonamide derivatives, imidazole derivatives, naphthalene derivatives, hydroxyanthranilic acid or salts thereof and derivatives thereof, anthranilic acid derivatives, coumarins Derivatives, amino acid derivatives (2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid, 2-amino-3- [1-carboxyl-2- (1H- Imidazol-4-yl) ethyl] aminobutanoic acid hydrochloride, 2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid sodium salt, 2-amino- 3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid potassium salt, etc.), benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, geo Xanthane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, ascorbic acid or salts thereof and derivatives thereof (phosphate-L-ascorbic acid magnesium, ascorbyl palmitate, ascorbyl dipalmitate, Ascorbic acid hydroxyproline phosphate, 5-o-α-D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate Magnesium salt, L-ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate mag Cium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid sulfate aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L -Aluminum ascorbate, 6-o-α-D-galactopyranosyl-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, magnesium L-ascorbate phosphate Salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o -Acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl-L-ascorbic acid, 6-o-alkyl Ascorbic acid phosphate potassium salt, 6-o-alkyl ascorbic acid phosphate calcium salt, 6-o-alkyl ascorbic acid phosphate barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o -Alkylascorbic acid phosphate monoethanolamine salt, 6-o-alkylascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate ester Monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o- β-D-galactopyranosyl-L-ascorbic acid, as Rubinic acid phosphate cholesterol ester, palmitic acid-L-ascorbyl, isopalmitic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L -Ascorbyl, distearic acid-L-ascorbyl, diisostearic acid-L-ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2 -Ethylhexanoic acid-L-ascorbyl, di-2-ethylhexanoic acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α- D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl - L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitate, L-ascorbic acid tetralaurate, L-2-ascorbic acid tetra-2-ethyl Hexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o- Ethyl ascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate , 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl] -4'-ace Xifellate, DL-α-tocopherol-2-L-ascorbic acid diester, ascorbic acid inositol-conjugated derivative, ascorbic acid phosphoramide derivative, ascorbic acid arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic Acid derivatives, etc.), tocopherols or salts thereof and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, Tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside Sid, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl Maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-toco Ferryl maltoside, 1- Rufoethylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol, 1- (carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol Hydrochloride, S- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl]- γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-iroxy) -2 -Hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol Russuccinate, tocotrienol linoleate, tocotrienol orotate, etc.), kojic acid or derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-Benzolyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran -4-one, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate , Kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.), oxybenzone, benzophenone, gua Iazulene, shikonin, baicalin or salts thereof and derivatives thereof, baicalein or salts thereof and derivatives thereof, berberine or salts thereof and derivatives thereof, chrysin or salts thereof and derivatives thereof, apigenin or salts thereof and derivatives thereof, luteolin Or salts thereof and derivatives thereof, acacetin or salts thereof and derivatives thereof, diosmethine or salts thereof and derivatives thereof, kaempferol or salts thereof and derivatives thereof, triphorin or salts thereof and derivatives thereof, astragalin or salts thereof And derivatives thereof, quercetin or salts thereof and derivatives thereof, quercitrin or salts thereof and derivatives thereof, isoquercitrin or salts thereof and derivatives thereof, rutin or salts thereof and derivatives thereof. Body, morin or a salt thereof and derivatives thereof, myricetin or a salt thereof and derivatives thereof, myricitrin or a salt thereof and derivatives thereof, datiscetin or a salt thereof and derivatives thereof, quercetagetin or a salt thereof and derivatives thereof, isorhamnetin or Salts thereof and derivatives thereof, pinocembrin or salts thereof and derivatives thereof, naringenin or salts thereof and derivatives thereof, hesperetin or salts thereof and derivatives thereof, eriodictyol or salts thereof and derivatives thereof, pinobankin or salts thereof and Derivatives thereof, aromadendrin or a salt thereof and derivatives thereof, engelitin or a salt thereof and derivatives thereof, taxofolin or a salt thereof and derivatives thereof, astilbine or a salt thereof and the same Derivatives, amperopsin or salts thereof, and derivatives thereof, spiraeoside, kaempferol-7-neohesperidoside, glutathione or salts thereof and derivatives thereof, isoflavone glycosides (6-o-apiosylpuerarin-4'-o -Glucosides, 6-o-glucosyl puerarin, 3'-hydroxy puerarin-4'-o-glucoside, 6-o-apiosyl-3'-hydroxy puerarin), γ-pyrone glycosides (maltol-3-o-) (6'-o-apiosyl) -glucoside, maltol-3-o- (6'-o-apiosyl) -glucoside, etc.), isononyl ferrate, ellagic acid or salts thereof and derivatives thereof (5,4-dimethyl) Ellagic acid, 3,3'-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-methoxyellagic acid, 3-ethyl-4-methyl- 5-hydroxy ellagic acid, amritoside, etc.), lucinol, ON Saponin, Bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin, senegin, benzoic acid anilides (4-hydroxy-N- (2-hydroxyphenyl) benzoic acid amide, 4-hydroxy-N- (3-hydroxyphenyl) ) Benzamide, 4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl -4-hydroxy-N- (3-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N- (2-hydroxyphenyl) benzamide, etc.), diphenylpyralin, cyproheptadine, triprolidine, dimethindene , Ozagrel, istipendil, iproheptin, homochlorcyclidine, alimemazine, bucillamine, oxytosamide, vidarabine, xanthotoxin Sole, phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide solution, zinc peroxide, placenta (bovine origin, pig origin, horse origin, sheep origin, etc.) extract, almond extract Ammarok Extract, Oyster Extract, Ovana Okella Extract, Ochera Extract, Konfuyo Extract, Uncaria Extract, Gaijicha Extract, Gypsophila Extract, Licorice Extract, Gardenia Extract, Kranigean Extract, Clara Extract, Koganebana (Ogon) ) Extract, wheat (wheat) extract, rice (rice) extract, Koreaia extract, Sidwaya extract, sun cucumber extract, sanvitro extract, sun pens extract, silane (bikkyu) extract, senkyu (river cucumber) extract, senna extract, sempukuka extract , Senkutsusai extract, Su Rigatin extract, Nodake (mae-hu) extract, pearl barley (yokuinin) extract, hamago extract, honey beetle extract, hamamelis extract, palm extract, parietalia extract, safflower (safflower) extract, mugwa (mulberry bark) ) Extract, malvanojadin (bitter gins) extract, purple squirrel extract, white squirrels extract, mugwort mugwort extract, yashajitsu extract, hongkong extract, bituminous (ground) extract, quail lily extract, scallop extract, scorpion extract and the like.

(2) Tyrosinase activity inhibitors Specifically, ascorbic acid or a salt thereof and derivatives thereof (phosphate-L-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyprophosphate phosphate ascorbate, 5- o-α-D-Glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate Calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L -Ascorbic acid sulfate Stell aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyrano Sil-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Ester sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl- L-ascorbic acid, 6-o-alkylascorbic acid phosphate potassium salt, 6-o-alkylascorbic acid phosphate Steal calcium salt, 6-o-alkyl ascorbic acid phosphate barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o-alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl Ascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanol Amine salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, phosphorus ascorbate Acid cholesterol ester, palmitic acid-L-ascorbyl, isopa Mycinate-L-Ascorbyl, Dipalmitate-L-Ascorbyl, Diisopalmitate-L-Ascorbyl, Stearic Acid-L-Ascorbyl, Isostearic Acid-L-Ascorbyl, Distearic Acid-L-Ascorbyl, Diisostearic Acid-L- Ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid-L-ascorbyl, di-2-ethylhexane Acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α- D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-malto Triosyl-L-ascorbic acid, L-ascorbic acid Trisopalmitic acid ester, L-ascorbic acid tetralauric acid ester, L-ascorbic acid tetra-2-ethylhexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, L- Ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbyl triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl cinnamate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphoric acid diester, Scorbic acid inositol-linked derivatives, ascorbic acid phosphoramide derivatives, ascorbic acid arbutin conjugates, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivatives, ascorbic acid sialic acid derivatives, etc.), hydroquinone or its salts and their derivatives (hydroquinone α-D-glucose) , Hydroquinone β-D-glucose, hydroquinone α-L-glucose, hydroquinone β-L-glucose, hydroquinone α-D-galactose, hydroquinone β-D-galactose, hydroquinone α-L-galactose, hydroquinone β-L-galactose, etc. Hexoses, hydroquinone α-D-ribose, hydroquinone β-D-ribose, hydroquinone α-L-ribose, hydroquinone β-L-ribose, hydroquinone α-D-arabinose, hydroquinone β-D -Five carbon sugar glycosides such as arabinose, hydroquinone α-L-arabinose, hydroquinone β-L-arabinose, hydroquinone α-D-glucosamine, hydroquinone β-D-glucosamine, hydroquinone α-L-glucosamine, hydroquinone β-L -Amino sugar glycosides such as glucosamine, hydroquinone α-D-galactosamine, hydroquinone β-D-galactosamine, hydroquinone α-L-galactosamine, hydroquinone β-L-galactosamine, hydroquinone α-D-glucuronic acid, hydroquinone β-D -Glucuronic acid, hydroquinone α-L-glucuronic acid, hydroquinone β-L-glucuronic acid, hydroquinone α-D-galacturonic acid, hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, hydroquinone β-L-galacturon Hydroquinone glycosides such as uronic acid glycosides such as acids Body, hydroquinone benzyl ether, 4-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) butane, 5-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) pentane, 6-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) hexane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propane, 2-β-D- Hydroquinone hydroxyalkyl ether glycosides such as glucopyranosyloxy-1- (4-hydroxyphenoxy) butane and 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propan-3-ol ), Kojic acid or a salt thereof and derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoluyloxy Methyl-5-hydroxy-4H-pyran-4-one, 2-cinna Iroxymethyl-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate , Kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.), tocopherol or salts thereof and derivatives thereof (Α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol Errol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside Sid, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl Maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocov Lyl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, L- (sulfoethylamino) -3- (α-tocopheryl-6-iroxy) Propan-2-ol, 1- (carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy ) -2-Hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl) -6-Iroxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α -Tocotrienol, β-Tocotrienol, γ-Toco Lienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate, etc.), N-acetyltyrosine or a salt thereof and derivatives thereof, glutathione or a salt thereof and derivatives thereof, ellagic acid Or a salt thereof and a derivative thereof (3,4-dimethylellagic acid, 3,3′-dimethylellagic acid, 3,3 ′, 4-trimethylellagic acid, 3,3 ′, 4,4′-tetramethyl-5 -Methoxyellagic acid, 3-ethyl-4-methyl-5-hydroxyellagic acid, amritoside, etc.), isonitrine A, isonitrine B, isonitrine C, isonitrine D, isonitrinic acid E, isonitrinic acid F, dermadein, tricobylidein, etc. Isonitrile antibiotics, orselinic acid derivatives (orceric acid, Ruthenic acid ethyl ester orcinol, p-geranylorceric acid, p-geranylorceric acid ethyl ester geranylorcinol, p-farnesylorselinic acid, p-farnesylorselinic acid ethylester farnesylorcinol, p-dodecanylol Serine acid, p-dodecanylorceric acid ethyl ester dodecanylorcinol, p-tetradecanylorceric acid, p-tetradecanylorceric acid ethylester tetradecanylorcinol, p-hexadecanylorceric acid P-hexadecanylorceric acid ethyl ester hexadecanylorcinol, p-undecanylorceric acid, p-undecanylorceric acid ethylester undecanylorcinol, p-tridecanylorceric acid, p-Tridecanylorceric acid ethyl ester undecanyl Orcinol, p-pentadecanylorceric acid, p-pentadecanylorceric acid ethyl ester pentadecanylorcinol, ethylhexylorceric acid, p-ethylhexylorceric acid ethylester ethylhexylorcinol, p-cyclohexylmethylorserine Acid, p-cyclohexylmethylorceric acid ethyl ester cyclohexylmethylorcinol, p-hydroxyethylhexylorceric acid methyl ester, p-hydroxyethylhexylorceric acid hydroxyethylhexylorcinol, etc.), umbelic acid, brefeldin, oxydesvera Trol, resorcinol derivative (4-cyclohexylresorcinol), 3-hydroxyketone compound (1,5-bis (p-hydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (o, p-di) Droxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (p-hydroxyphenyl-m-methoxyphenyl) -2-hydroxypentan-4-one, etc.), 1,3-diketone compounds (1 , 5-bis (p-hydroxyphenyl) -2,4-pentanedione, 1,5-bis (o, p-dihydroxyphenyl) -2,4-pentanedione, 1,5-bis (p-hydroxyphenyl- m-methoxyphenyl) -2,4-pentanedione), bishydroxybenzyl amides, γ-aminobutyric acid or its derivatives (N-methyl-γ-aminobutyric acid, N-dimethyl-γ-aminobutyric acid, γ-amino) Butyric acid oleyl ester), hydrogen peroxide, zinc peroxide, placenta extract, lucinol, silk extract, acacia extract, acerola extract, ichibi (winter position) extract, weeping birch extract, quellus extract, chestnut extract, kameba hikokoshi extract , Kuroba Nahi-Kokoshi extract, Toki-shiki (life-extending grass) extract, Seri extract, buckwheat extract, Davilia extract, Nazuna extract, Fujiba kama (Orchid grass) extract, chamomile extract, mulberry extract, gardenia extract, Japanese cypress extract, burnet extract, clara extract, mugwort extract, honeysuckle extract , Yellowfin extract, dokudami extract, pine-hodo extract, barley extract, scotch extract, hop extract, hawthorn extract, eucalyptus extract, yarrow extract, altea extract, cinnamon extract, mandarin extract, hamamelis extract, yamagwa extract, bellflower extract, toshishi extract, continued Suicho extract, sprayed extract, maize extract, senkyu extract, dokkatsu extract, psycho extract, boufu extract, kingfish extract, oxon extract, peony skin extract Peony extract, Geranium thunbergii extract, kudzu root extract, licorice extract, gallnut extract, aloe extract, Cimicifuga extract, safflower extract, green tea extract, black tea extract, include Uncaria gambir Roxburgh extract, and the like.

(3) Melanocyte melanin production inhibitor
Specifically, lobeline or lobeline derivatives, liquiritin derivatives (eg, liquiritin-α-glucoside, liquiritin-α-maltoside, etc.), phenylchroman derivatives, chromone derivatives (2-butylchromone, 2-pentylchromone, 2-heptylchromone, 2 -Nonylchromone, 2-hexadecylchromone, 2- (1-ethylpentyl) chromone, 2-butyl-7-methoxychromone, 2-pentyl-7-methoxychromone, 2-heptyl-7-methoxychromone, 2-nonyl- 7-methoxychromone, 2-pentadecyl-7-methoxychromone, 2- (1-ethylpentyl) -7-methoxychromone, 7-hydroxy-2-methylchromone, 7-hydroxy-2-butylchromone, 7-hydroxy- 2-pentylchromone, 7-hydroxy-2-heptylchromone, 7-hydroxy-2-nonylchromone, 7-hydroxy-2-pentadecylchromone, 7-hydro Cis-2- (1-ethylpentyl) chromone), azelaic acid derivatives (azelaic acid monoalkyl ester, azelaic acid dialkyl ester, etc.), phosphatidylglucosamine, lysophosphatidylglucosamine, phenylhydroquinone, 3-β-D-glucopyrano Silmanur, 3-β-D-maltopyranosylmanur, substituted amino acid derivatives (DL-N-formyl-3- (1-naphthyl) alanine, DL-N-acetyl-3- (1-naphthyl) alanine, DL -N-propionyl-3- (1-naphthyl) alanine, DL-N-butyryl-3- (1-naphthyl) alanine, DL-N-isobutyryl-3- (1-naphthyl) alanine, DL-N-valeryl- 3- (1-naphthyl) alanine, DL-N-isovaleryl-3- (1-naphthyl) alanine, DL-N- (2-methylvaleryl) -3- (1-naphthyl) alanine, DL-N- (3- Methyl valeryl) -3- (1-naphthyl) alanine, DL-N- (4-methyl) Ruvalyl) -3- (1-naphthyl) alanine, DL-N-t-butylacetyl-3- (1-naphthyl) alanine, DL-N-pivaloyl-3- (1-naphthyl) alanine, DL-N-caproyl -3- (1-naphthyl) alanine, DL-N- (2-ethylhexanoyl) -3- (1-naphthyl) alanine, DL-N- (2-methylhexanoyl) -3- (1-naphthyl) Alanine, DL-N-Heptanoyl-3- (1-naphthyl) alanine, DL-N-octanoyl-3- (1-naphthyl) alanine, DL-N- (2-propylpentanoyl) -3- (1-naphthyl) ) Alanine, DL-N-nonanoyl-3- (1-naphthyl) alanine, DL-N-decanoyl-3- (1-naphthyl) alanine, DL-N-undecanoyl-3- (1-naphthyl) alanine, DL- N-dodecanoyl-3- (1-naphthyl) alanine, DL-N-tridecanoyl-3- (1-naphthyl) alanine, DL-N-tetradecanoyl-3- (1-naphthyl) alanine, DL-N-pentadecanoy -3- (1-naphthyl) alanine, DL-N-hexadecanoyl-3- (1-naphthyl) alanine, DL-N-heptadecanoyl-3- (1-naphthyl) alanine, DL-N-octadecanoyl- 3- (1-naphthyl) alanine, DL-N-nonadecanoyl-DL-3- (1-naphthyl) alanine, DL-N-icosanoyl-3- (1-naphthyl) alanine, DL-N-acroyl-3- ( 1-naphthyl) alanine, DL-N-crotoniloyl-3- (1-naphthyl) alanine, DL-N-methacryloyl-3- (1-naphthyl) alanine, DL-N-vinylacetyl-3- (1-naphthyl) Alanine, DL-N-cyclopropanoyl-3- (1-naphthyl) alanine, DL-N- (2-pentenoyl) -3- (1-naphthyl) alanine, DL-N- (4-pentenoyl) -3- (1-naphthyl) alanine, DL-N- (2-hexenoyl) -3- (1-naphthyl) alanine, DL-N- (3-hexenoyl) -3- (1-naphthyl) alanine, DL-N- ( 2-methyl-3-pente Yl) -3- (1-naphthyl) alanine, DL-N-cyclohexenoyl-3- (1-naphthyl) alanine, DL-N- (10-undecenoyl) -3- (1-naphthyl) alanine, DL-N-linoleyl-3- (1-naphthyl) alanine, DL-N-hydroxyacetyl-3- (1-naphthyl) alanine, DL-N- (6-hydroxycaproyl) -3- (1-naphthyl) Alanine, DL-N- (8-hydroxyoctanoyl) -3- (1-naphthyl) alanine, DL-N- (9-hydroxynonanoyl) -3- (1-naphthyl) alanine, DL-N- (10 -Hydroxydecanoyl) -3- (1-naphthyl) alanine, DL-N- (11-hydroxyundecanoyl) -3- (1-naphthyl) alanine, DL-N- (12-hydroxydecanoyl) -3 -(1-naphthyl) alanine, DL-N-benzoyl-3- (1-naphthyl) alanine, DL-N- (2-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3- Hydroxybenzoyl -3- (1-naphthyl) alanine, DL-N- (4-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (o-toluyl) -3- (1-naphthyl) alanine, DL -N- (m-toluyl) -3- (1-naphthyl) alanine, DL-N- (p-toluyl) -3- (1-naphthyl) alanine, DL-N- (1-naphthoyl) -3- ( 1-naphthyl) alanine, DL-N- (2-naphthoyl) -3- (1-naphthyl) alanine, DL-N- (2-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- ( 3-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (4-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (2-picoryl) -3- (1- Naphthyl) alanine, DL-N- (3-picolyloyl) -3- (1-naphthyl) alanine, DL-N- (4-picolyloyl) -3- (1-naphthyl) alanine, DL-N-phenylacetyl-3 -(1-Naphthyl) alanine, DL-N- (2-Phenylpropanoyl -3- (1-naphthyl) alanine, DL-N- (3-phenylbutyryl) -3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine, DL-N-valeryl-3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alaninamide, DL-N- (4-methylvaleryl) -3- (1- Naphthyl) alanine methyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine ethyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine propyl ester, DL- N- (4-methylvaleryl) -3- (1-naphthyl) alanine-N-butyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine pentyl ester, DL-N- (4- Methylvaleryl) -3- (1-naphthyl) alanine isopropyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine isobutyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine-t-butyl ester, etc.), benzolactam derivatives, indolactam derivatives, cedrol, guaiool, 1- (4-hydroxyphenithio) -2- Propanol, β-lactoglobulin, 2-methoxy-5-methylphenol, 5-ethyl-2-methoxyphenol, 5-N-propyl-2-methoxyphenol, 5-N-butyl-2-methoxyphenol, 5-N -Hexyl-2-methoxyphenol, 5-N-heptyl-2-methoxyphenol, 5-N-decyl-2-methoxyphenol, 5- (1,1-dimethylpropyl) -2-methoxyphenol, 5- (1 , 1-dimethylbutyl) -2-methoxyphenol, 5- (1,1-dimethylethyl) -2-methoxyphenol, 2-methoxy-5- (1-methylpentyl) phenol, 2-methoxy-5- (1 -Methylhexyl) phenol, 2-methoxy-5- (3-methylhexyl) ) Phenol, 2-methoxy-5- (6-methylheptyl) phenol, 5- (1,3-dimethylheptyl) -2-methoxyphenol, malvelin, ferguinol, sugiol, cryptojaponol, 1,5-bis [p -Hydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [o-hydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [2,4-dihydroxyphenyl] ] -1,4-pentadien-3-one, 1,5-bis [3-methoxy-4-hydroxyphenyl] -1,4-pentadien-3-one, haginin, agrimophor, agrimol, hydrangenol or its Derivatives, alkylresorcinol or its derivatives (such as 4-N-butylresorcinol), aristolone, caramenene (such as caramenene, 7-hydroxycaramenene, 5-hydroxycaramenene, 7-methoxycaramenene), trans-umbe Acid, N-α-benzoyl-L-arginine, N-α-benzoyl-L-arginine ethyl ester or N-α-benzoyl-L-arginine ethyl ester, 5-methyl-2 (3H) -furanone, 2-butene -4-Orido, 2-hydroxymethylfuran, 2,5-dimethyl-4-hydroxy-3 (2H) -furanone, 2-formylfuran, 3-formylfuran, methyl α-furyl ketone, furfuryl acetate, 2-hydroxy -3-methyl-2-cyclopenten-1-one, 2-hydroxy-3,5-dimethyl-2-cyclopenten-1-one, 2,5-dimethyl-4-hydroxy-3 (2H) -thiophenone, 2- Hydroxy-3-ethyl-2-cyclopenten-1-one, tetronic acid, pentanedione, iminodibenzyls (2,2'-iminodibenzyl, imipramine, imipramine hydrochloride, desipramine, desipramine hydrochloride, chlorimipramine, trimipramine, etc. ), Dibenzocyclohe Tadienes (amitriptyline, amitriptyline hydrochloride, nortriptyline, noxiptylline, etc.), tetrahydrocopalol glycosides (ketotifen fumarate, labda-8 (17), 13-dien-15-ol, tetrahydromanol, tetrahydrocoparol, tetrahydro Copalol glucoside, tetrahydrocoparol galactoside, tetrahydrocoparol maltoside, tetrahydrocoparol cellobioside, tetrahydrocoparol maltotrioside, etc.), spiro ether compound, piokerin, phenothiazine compound, promethazine, alimemazine, alimemazine tartrate, triflupromazine , Levomepromazine, chlorpromazine, cyclandrate, 4-carboxymethyloxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3- (3- Ruboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) benzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4 -(3-carboxypropyl-1-oxy) -2-methoxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy)- 2-hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid, 4- (10-carbamoyl) Decan-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) benzoic acid, 4- (4-hydroxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- ( 4-acetoxybutyl-1-oxy) benzoic acid, 4- (4-acetoxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-etho Cycarbonylpropyl-1-oxy) -2-hydroxybenzoic acid, 3- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-methoxybutyl-1-oxy) -2 -Hydroxybenzoic acid, 4- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3- (3-carboxypropyl-1-oxy) 2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 6- (3- Carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) -2-hydroxybenzoic acid Acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid, hydroxytrimethyl Cyclohexanes (2-hydroxy-4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -1-butene, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2-butene, 4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 3-methyl-3-hydroxy-5- ( 2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-5- ( 2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -3-pentene, 3-methyl- 3-Hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -1-pentene, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane ) -2-Pentene, 2-Hydroxy-4 -(2,2,6-trimethyl-1-yl-cyclohexane) butane and other monosaccharides, disaccharides or trisaccharide glycosides), escinol, parahydroxycinnamic acid-4- (2,2,6-trimethyl) -Yl-cyclohexane) -2-butyl ester monosaccharide, disaccharide or trisaccharide glycoside, ondisaponin, bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin, senegin, 4- (2,2,6 -Torime
Tyl-1-yl-cyclohexane) -2-keto-butane, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto-butane, 4- (2,2,6- Trimethyl-1-yl-cyclohexane) -2-keto-3-butene, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto-3-butene (β-ionone), Lp-hydroxyphenylglycine, Dp-hydroxyphenylglycine, N-benzyloxycarbonyl-Lp-hydroxyphenylglycine, N-benzyloxycarbonyl-Dp-hydroxyphenylglycine, N-benzoyl-Lp-hydroxyphenylglycine, N-benzoyl- Dp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Dp-hydroxyphenylglycine, N- (p-hydroxybenzoyl) -Lp-hydroxyphenylglycine , N- (p-hydroxybe Nzoyl) -Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine, N-acetyl-Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine ethyl ester, N-acetyl-Dp-hydroxyphenylglycine Ethyl ester, N-acetyl-Lp-hydroxyphenylglycinamide, N-acetyl-Dp-hydroxyphenylglycinamide, Lp-methoxyphenylglycine, Dp-methoxyphenylglycine, Lp-methoxyphenylglycine hydrochloride, Dp-methoxyphenylglycine Hydrochloride, 4-hydroxy-3-methoxy-L-phenylglycine, 4-hydroxy-3-methoxy-D-phenylglycine, Lp-hydroxyphenylglycine ethylamide, Dp-hydroxyphenylglycine ethylamide, N-tert-butoxy Carbonyl-Lp-hydroxyphenylglycine, N -tert-butoxycarbonyl-Dp-hydroxyphenylglycine, N-tert-butoxycarbonyl-Lp-methoxyphenylglycine, N-tert-butoxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp -Methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxyphenylglycine benzyl ester hydrochloride, N-9-fluorenyl Methyloxycarbonyl-Dp-methoxyphenylglycine benzyl ester hydrochloride, Lp-hydroxyphenylglycinamide, Dp-hydroxyphenylglycine amide, Lp-hydroxyphenylglycine allyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine allyl ester p -Toluenesulfonate, Lp- Droxyphenylglycine benzyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine benzyl ester p-toluenesulfonate, Lp-hydroxyphenylglycine ethyl ester, Dp-hydroxyphenylglycine ethyl ester, Lp-hydroxyphenylglycine ethyl ester Hydrochloride, Dp-hydroxyphenyl glycine ethyl ester hydrochloride, Lp-hydroxyphenyl glycine methyl ester, Dp-hydroxyphenyl glycine methyl ester, etc., 1,3-diallylindane-2-carboxylic acids, stachybosines, pheophorbide derivatives, eleucerin, Isoeleucerin or 4-β-hydroxyisoereucerine, eleucerinol, spiroketal derivatives (2- (2,4-hexadinylidene) -1,6-dioxaspiro [4.5] dec-3-ene, 2- (2-hexynyl ) -1,6-dioxaspiro [4.4] non-3-ene, 2-((4-methylphenyl) methylidene) -6,6-dioxaspiro [4.4] non-3-ene, 2- (2-hexenylidene) -6,6-Dioxaspiro [4.5] dec-3-ene, 2- (2-hexenylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-hexyl-1,6-dioxaspiro [4.4] nonane 2- (2-hexenyl) -1,6-dioxaspiro [4.4] nonane, 2- (2-hexynyl) -1,6-dioxaspiro [4.4] nonane, 2-pentyl-1,6-dioxaspiro [4.4] nonane 1,6-dioxaspiro [4.4] nonane, 1,6-dioxaspiro [4.5] decane, 1,7-dioxaspiro [5.5] undecane, 2,3-benzo-4,4-dimethyl-1,6-dioxaspiro [4.4 Nonane, 3,4-benzo-2-pentyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-hexyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2 -Octyl-1 , 6-Dioxaspiro [4.4] nonane, 2-hexyl-9,9-dimethyl-1,6-dioxaspiro [4.4] nonane, 2- (2,4-hexadiynylidene) -1,6-dioxaspiro [4.4] nona -3-ene, etc.), malvalic acid, phosphonic acid derivatives or salts thereof, aspergillomalasmin, aminophosphonic acid derivatives or salts thereof, diphenhydramine or salts thereof, pregnenolone or derivatives thereof, lutein, farnesyl isopropanol derivatives, hexahydrofarnesyl acetone 4-benzoylamino-2-hydroxybenzoic acid, 5-benzoylamino-2-hydroxybenzoic acid, 4-benzoylaminobenzoic acid, 4- (1-naphthoylamino) -2-hydroxybenzoic acid, 5- (1 -Naphthoylamino) -2-hydroxybenzoic acid, 4- (2-naphthoylamino) -2-hydroxybenzoic acid, 5- (2-naphthoylamino) -2-hydroxybenzoic acid Acid, 4- (1-naphthoylamino) benzoic acid, 4- (2-naphthoylamino) benzoic acid, 4-phenylaminocarbonylbenzoic acid, 4-phenylaminocarbonyl-2-hydroxybenzoic acid, 5-phenylamino Carbonyl-2-hydroxybenzoic acid, 4- (1-naphthylaminocarbonyl) benzoic acid, 4- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid Acid, 4- (2-naphthylaminocarbonyl) benzoic acid, 4- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, hexahydrofarnesyl isopropanol Derivatives, borneol-p-hydroxycinnamate glucoside, borneol-p-hydroxycinnamate maltoside, borneol-p-hydroxy Cinnamic acid ester maltotrioside, cinnamic acid-4- (2,2,6-trimethyl-yl-cyclohexane) -2-butyl ester derivative, 2,4-dihydroxybenzophenone, 1- (2,4-dihydroxyphenyl) -Ethanone (2 ', 4'-dihydroxyacetophenone), 1- (2,4-dihydroxyphenyl) -1-propanone (2', 4'-dihydroxypropiophenone), 1- (2,4-dihydroxyphenyl) -1-butanone, 1- (2,4-dihydroxyphenyl) -1-pentanone, 1- (2,4-dihydroxyphenyl) -1-hexanone, 1- (2,4-dihydroxyphenyl) -1-heptanone, 1- (2,4-dihydroxyphenyl) -1-octanone, 1- (2,4-dihydroxyphenyl) -1-nonanone, 1- (2,4-dihydroxyphenyl) -1-decanone, 1- (2, 4-dihydroxyphenyl) -1-undecanone, 1- (2,4-dihydroxyphenyl) -1-dodecanone, 1- (2,4- Dihydroxyphenyl) -1-tetradecanone, 1- (2,4-dihydroxyphenyl) -1-hexadecanone, 1- (2,4-dihydroxyphenyl) -1-octadecanone, 1- (2-hydroxy-4-methoxyphenyl) -Ethanone (2'-hydroxy-4'-methoxyacetophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-propanone (2'-hydroxy-4'-methoxypropiophenone), 1- (2 -Hydroxy-4-methoxyphenyl) -1-butanone, 1- (2-hydroxy-4-methoxyphenyl) -1-pentanone, 1- (2-hydroxy-4-methoxyphenyl) -1-hexanone, 1- ( 2-hydroxy-4-methoxyphenyl) -1-heptanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octanone, 1- (2-hydroxy-4-methoxyphenyl) -1-nonanone, 1- (2-hydroxy-4-methoxyphenyl) -1-decanone, 1- (2-hydroxy-4-methoxy) Ciphenyl) -1-undecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-dodecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-tetradecanone, 1- (2-hydroxy-4- Methoxyphenyl) -1-hexadecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octadecanone, 1- (4-hydroxy-2-methoxyphenyl) -ethanone (4'-hydroxy-2'-methoxyacetophenone) ), 1- (4-hydroxy-2-methoxyphenyl) -1-propanone (4'-hydroxy-2'-methoxypropiophenone), 1- (2,4-dimethoxyphenyl) -ethanone (2 ', 4 '-Dimethoxyacetophenone), 1- (2,4-dimethoxyphenyl) -1-propanone (2', 4'-dimethoxypropiophenone), lactone derivative (1,6-dioxaspiro [4.4] nonane-2,7- Dione, 1,6-dioxaspiro [4.5] decane-2,7-dione, 4-tridecanolide 4-dodecanolide, 4-undecanolide, 4-decanolide, 4-nonanolide, 4-octanolide, 4-heptanolide, 5-dodecanolide, 5-undecanolide, 5-decanolide, 5-nonanolide, 5-octanolide, 2-undecen-4- Orido, 2-Decene-4-Olide, 2-Nonene-4-Olide, 2-Heptene-4-Olide, 2-Undecen-5-Olide, 2-Decene-5-Olide, 2-Nonene-5-Olide, 2-octene-5-olide, 4-methyl-4-dodecanolide, 4-methyl-4-undecanolide, 4-methyl-4-decanolide, 4-methyl-4-nonanolide, 4-methyl-4-heptanolide, 5- Methyl-5-dodecanolide, 5-methyl-5-undecanolide, 5-methyl-5-decanolide, 5-methyl-5-nonanolide, 5-methyl-5-octanolide, 2-methoxycarbonyl-4-dodecanolide, 2-methoxy Carbonyl-4-undecanolide, 2-methoxycarbonyl-4-decanolide, 2-methoxycar Nyl-4-nonanolide, 2-methoxycarbonyl-4-heptanolide, 2-methoxycarbonyl-5-undecanolide, 2-methoxycarbonyl-5-decanolide, 2-methoxycarbonyl-5-nonanolide, 2-methoxycarbonyl-5-octanolide 2-allyl-4-undecanolide, 2-allyl-5-decanolide, 2-allyl-4-nonanolide, 2-pentyl-4-undecanolide, 2-pentyl-4-nonanolide, 2-methyl-4-undecanolide, 2 -Methyl-4-nonanolide, 2- (4-hydroxybutyl) -4-undecanolide, 2- (4-hydroxybutyl) -4-nonanolide, 2- (4-hydroxybutyl) -5-decanolide, 5-propyloxy -4-pentanolide, 5-allyloxy-4-pentanolide, 5- (2-hydroxyethoxy) -4-pentanolide, 8-hydroxy-4-octanolide, 6-propyloxy-5-hexanolide, 6-allyloxy-5-hexanolide , 6- (2- Hydroxyethoxy) -5-hexanolide, 9-hydroxy-5-nonanolide, etc.), ethinomycin, iriflorental, iriparidal, 2'-8-C-glucosyl-7-methylaloesol coumaroyl ester, 2'-8- C-Glucosyl-7-methyl aloesol cinnamoyl ester, chloropyramine, anise extract, aloe extract, itadori (tiger cane root) extract, seaweed extract, shrimp rush extract, ketsumeishi (Kameko) extract, sea urchin extract , Paramecium (calocon) extract, Onamomi (Tempura) extract, Oni Yagara (Tempa) extract, Oyster extract, Ginseng extract, Oyaku extract, Pumpkin extract, Gama (Yellow yellow) extract, Kansui extract, Kimizuki (Senkuru) Grass) extract, black moji extract, black spruce extract, sisal Sisal extract, Saximas button extract, Chinese button extract, Chinese ginseng extract, Oshima cherry extract, Oya cherry extract, Bean cherry extract, Takane cherry extract, Kohigan extract, Sato cherry extract, Zion extract, Shiro extract, Shirobana Iris extract, ginseng extract, potato beetle extract, diamondfish extract, primrose extract, toshishi extract, bean extract, Japanese pear extract, sagebrush extract, yarrow extract, dill extract, honey beetle extract, Clams extract, Hitotsuba (stone persimmon) extract, Himegama (cranberry) extract, peony extract, floral blanka extract, hamula extract, sagebrush extract, hill O extract, sandalwood extract, red mushroom extract (reishi mushroom extract), swordfish (beneficial herb) extract, river willow extract, red willow extract, cat willow extract, catfish willow extract, quince willow extract, cory willow extract, unryu willow extract, yama willow extract, weeping willow Willow extract, Chinese cabbage extract, Fox willow extract, Doronoki extract, Japanese yam extract, Agave mid-autumn, Aono Agave extract, Fu
Crested Agave Extract, Mitsumata Extract, Aonori Extract, Usubaaonori Extract, Susioonori Extract, Hiraaonori Extract, Bowuaonori Extract, Hosoeda Aonori Extract, Kombu Extract, Macombu Extract, Resilibum Extract, Hosome Kombu Extract, Mitsuishi Kombu Extract, Wakame Extract Aowakame extract, hijiki extract, hibamata extract, sea urchin extract, sea bass extract, sea bream water extract, red sea urchin extract, sea urchin extract, sea urchin extract, sea bass extract, sea urchin extract, seaweed extract Extract, giraffe rhinoceros extract, juniper ginseng rhinoceros extract, tsunomata extract, ibottsu nomata extract, malvatsu nomata extract, Lakotoji extract, Sugi nori extract, Shikinori extract, Kainori extract, Yakuzusa extract, Urabo shiyahaz extract, Umiuchiwa extract, Ishimozuku extract, Misjikonbu extract, Atsuba misji extract, Isomok extract, Nagashima mok extract, Shimomoku extract, Nemosa extract , Tatsumoku Extract, Yatsutama Tamoku Extract, Umitorano Extract, Oba Moku Extract, Fusis Mimoku Extract, Haha Moku Extract, Yoremok Extract, Sawtooth Moku Extract, Psyllium Moku Extract, Mukadenori Extract, Nuraxa Extract, Cronouraxa Extract, Oomkadenori Extract, Oomkadenori Extract Steller's root extract, Sponge extract, Fushitsunagi extract, Himefushitsunagi extract, Hirohafushitsugi extract, Black Zoekisu, Kobusozoekisu, Hanesozoekisu, Sozonohanaekisu, brush Saki sawtooth Hiba extract, Thira extract, duck over Tede bruises franc extract, Hamaikaekisu, port Leo Verde extract, Nabo Negro extract, Schisandra chinensis extract, Matsubusa extract, Binankazura extract, and the like.

(4) Melanin production promoter Specifically, salicylic acid or a salt thereof and derivatives thereof (salicylic acid glucoside, salicylic acid fatty acid ester, salicylic acid alcohol ether, salicylic acid amides, etc.), salicyl alcohol or a salt thereof and derivatives thereof, apigenin, Mentoflavone, Salamander extract, Udo extract, Shishido extract, Nirinso extract, Oak extract, Bovine Taxus extract, Cuckoo thistle extract, Gypsophila extract Extract, jasmine (pine licorice) extract, hollyhock extract, scallop extract, Arabidopsis thaliana extract, lily of the valley extract, sawnose extract, deco extract, eucommia extract Squid (Butcher Bloom) Extract, Teppouri Extract, Tokiwa Mansaku Extract, Groundnut Extract, Niwarushi Extract, Nadeshiko Extract, Michiyanagi Extract, Elderflower Extract, Morohaya Extract Zakifujime extract, Ryokakou extract, Ajigusa extract, Shellfish extract (cockle extract, green mussel extract, oyster extract, European oyster extract, scallop extract, clam extract, clam extract, snail extract, red mussel extract, red mussel extract, abalone extract, Sazae extract, bi-extract, etc.).

(5) Moisturizer Specifically, ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, pentyl glycol, hexylene glycol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,6-hexanediol, glycerin, erythritol, Pentaerythritol, dipentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lath Polyhydric alcohols such as tititol, maltitol, sicilitol, laminitol, valienamine, validamine, and validatol, gum arabic, benzoin rubber, dammar gum, guaiac fat, Irish moss, Karaya gum, tragacanth gum, carob gum, quinseed, agar or its derivatives, casein , Glucose, galactose, mannose, xylose, fructose, maltose, isomaltose, cellobiose, gentiobiose, trehalose, cordobiose, laminaribiose, nigerose, cellobiose, sambibiose, neohesperidose, apiose, hammamellose, streptose, hydroxystreptose Toose, 2-methylerythrose or its derivative, 2-methylerythronolactone, my Loin, cladinose, acneose, alkanose, olivomai course, chromose, ebamise, vinerose, nogarose, billenose, nobiose, moenuronic acid, galosamine, cibirosamine, N-acylcansosamine, vancosamine, evanitrose, rubranitrose, tetronitrose, pyralose, α Sugars such as octose, trioxacalcinose, aldogalose, blastminosin or esters thereof, trehalose or derivatives thereof, D-mannosamine and derivatives thereof, isomaltoligosaccharide (panose), primeverose or derivatives thereof, dextrin, gelatin, pectin, Hydroxyl with added alkylene (C2-C4) oxide such as starch, carrageenan, carboxymethyl chitin or chitosan, ethylene oxide Alkyl (C2-C4) chitin or chitosan, low molecular chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or salt thereof, 1, 3-β-glucan, 1,4-β-glucan, 1,6-β-glucan, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose, carboxyethylcellulose, sodium carboxyethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, nitrocellulose, crystalline cellulose , Hydroxypropyl methylcellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyethylene oxide and polypropylene Polyalkylene oxides such as oxides or cross-linked polymers thereof, carboxyvinyl polymers, water-soluble polymers such as polyethyleneimine, dermatan sulfate, keratan sulfate, glycerin fatty acid pyrrolidone carboxylic acid esters, glycerin fatty acid acetyl amino acid esters, pyrrolidone carboxylic acid Acid or salt thereof, polyaspartic acid or salt thereof, polyglutamic acid or salt thereof, polylysine or salt thereof, sodium lactate, hydantoin and derivatives thereof, Np-vinylbenzyl-D-cellobionamide, Np-vinylbenzyl-D-lactone Amide, Np-vinylbenzyl-D-maltonamide, Np-vinylbenzyl-D-gluconamide, glucosyloxyethyl methacrylate, galactosyloxypropyl acrylate, mannosyloxyethyl methacrylate, glutamyl Lysine, glutaurine, 1,2,4-butanetriol, caran-3,4-diol, azoxaponin (3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -sophoradiol, 3- o- [β-D-glucopyranosyl-3-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -azuxapo Genol, 3-o- [β-D-glucopyranosyl] -28-o- [β-D-glucopyranosyl-β-D-glucopyranosyl] -dipsogenic acid, 3-o- [α-L-rhamnopyranosyl-β-D -Glucopyranosyl-β-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -29-o- [β-D -Glucopyranosyl-β-D-glucopyranosyl] -Azoxapogenol, etc.), Aoki (Aoki) extract, Aogiri extract, Kenashia Ogiri (Toho) extract, Red pepper ( Red red hemp) extract, red clover extract, Aki larch extract, Aguahe (Omanten palm) extract, Malva morning glory extract, morning glory (Chicken) extract, Athira (Shokuyo kanna) extract, oilseed rape extract, Amachazul extract, Amana extract , Ayuyu extract, Hagetou extract, Homogetou extract, Senninoku extract, Sugi Morigetou extract, Hosoaogeito extract, Aogatetou extract, Hariyuyu extract, Aozulan extract, Amaranthus hippochondriax extract, Aristolomeria (Yurizuisen) extract, Arcana (Arcanna) extract, Algarrobo (Cabbage) extract, Aloe vera extract, Rabbit (Kanshin grass) extract, Yew (first place) extract, Strawberry extract, Carob bean extract, Inazuna (Tailexi) extract, Rice extract, Dog Occasion extract, Iwa tobacco extract, Iwahiba extract, Iwamatsu extract, Wheat extract, Duckweed extract, Usbenitachai extract, Usenia extract, Unyadegato extract, Enokitake mushroom ) Extract, eringi extract, pre-lotus eringi extract, ogatahouken extract, oguruma (civil engineering incense) extract, euglena (cereal essence) extract, oka extract, okazeri (serpentine) extract, okra extract, onidokoroko extract, tokoro extract , Nagadokoro (hikai) extract, Ononis extract, Oyuko extract, Oyster extract, Ginseng extract, Gaku hydrangea extract, Cascara grada extract, Gypsophila extract, Panax ginseng extract, Kaniwa extract, Carnation extract, Gerberae , Camcoma (camo duck) extract, Color extract, Oats extract, Karin (Kiso) extract, Kawara Psycho (Sugar), Kawajisha extract, Kawaranadeshiko (Shitake) extract, Ezokawaranadeko (Soba, Oats) extract , Kantarasa extract, Kikutaniku extract, quinoa (quinoa) extract, cabbage extract, kiwi extract, cucumber extract, gyory (Nishikawa willow) Kudzu extract, kokujinjin (yellow flower bud) extract, cupuasu extract, gumbai nazuna (Sekimei, Sekimeishi) extract, Kemponashi (Kigushi) extract, gekkavidin (Beautiful under the moon) extract, Koolen (Huo Ren) extract, coconut extract, cosmos Extract, coconut lees extract, rice oil extract Konjac extract, saffron extract, sapodilla extract, sangre degrad (croton) extract, sanchinin ginseng (37 ginseng) extract, shea (carite) extract, cyanoki extract, shiitake extract (shiitake) extract, shimeji extract , Hinshimeji extract, Shakashimeji extract, Hatake shimeji extract, Oshiroi shimeji extract, Beech shimeji extract, Honjimeshi extract, Shirotamagitake extract, Shimokurene extract, Saishin extract, Cactus extract, Janohige (bara winter) extract, Shukukonka miso extract, Zhu Zan hydrangea (Tsuneyama) extract, white-faced butterfly extract, white-leafed adzuki bean (chicken bone) extract, ginkgo biloba (Mizuka, Mizuka flower, Shencho flower) extract, watermelon (Western phoenix) extract, Suzu-Psycho (Xu-long moth) extract, Suveruhi (horse tooth soap, horse Toothpaste extract, secrecy Kisses, cherry blossoms extract, Japanese apricots extract, Japanese apricots extract, Japanese apricots extract, Honsekoku extract, Japanese butterflies extract, Shikakekokukoku extract, Kibananosekoku extract, Cedron extract, Zenia oyster extract, celery extract Shinren) extract, Japanese radish extract, Takasaburo extract, Tachidokoro (hikai) extract, dahlia (tenjiku button) extract, Talwe extract, Senganshi extract, Sojitsu extract, Chankapiedora (Kidachikokankanso) extract, Tulip extract, Chorogi extract, Tsukuritake (mushroom) extract, camellia extract, clover (lacquered licorice) extract, Tounabena (river cut) extract, corn extract, corn hair (southern cocoon) extract, Tokusa ( Bandit) extract, ash (crust) extract, Turkish Kyary extract, jujube extract, vertical bean (sword bean) extract, jujube (large cocoon) extract, navena (continuous) extract, sea cucumber extract, namban ramie (seed) extract, iois violet Extract, nutmeg extract, Nemum extract, Nebu extract, Nebi extract, Nemurioki extract, Digokubana (community) extract, Nogateto extract, Hylindough extract, Hauchiwa extract, Hauchi bean extract, Papaya extract, Pahalobobo extract, Balata rubber extract, Haratake extract, White oharatake extract Usukimori nokasa extract, haran extract, pariurus (Amanita spp.) Extract, balsamina (crane licorice, bitter gourd) extract, harlindough extract, hand daikai (胖大海) extract, hygurum dahlia extract, beet extract, fly fly , Sunflower extract, bell pepper extract, Himezu (Tenpo) extract, Himematsutake (Kawariharatake, Hiromatsutake) extract, Euphorbicus extract, Brazilian licorice extract, hazelnut extract, loofah extract, red snapper extract, squirrel extract Bakigi extract, narcissus extract, nendo extract, Hahagigi Kokia (geum sorghum) extract, spinach (Akansen, Acute pupa, periosteum) extract, Falcona extract, Hosobakirinso (Keiten No.7) extract, Jojoba extract, Borage ( (Rurichisha) extract, Bordeaux extract, Hononiku (meat jugo, Daiki) extract, Honsekkok (iron skin stone, sparrow mountain stone) extract, maca extract, macadamia nut extract, margaret (mokushungiku) extract, tamanozenhalen extract, Kyukonkinrenka D , Matatabi extract, Matsukasa extract, Matsuhodo (茯苓) extract, Matico (Cordon sillo) extract, Quince extract, Malene (Biloud mud squid) extract, Manzanya (Andesca mite) extract, Mizusobako extract, Mizuasagao (dragon) Tongue extract), green mint extract, wheat straw extract, munya extract, murasakiki kibu extract, murmur sakikibu extract Extract, Palm Extract, Yabu Tobacco (Crane Straw, Tennasei) Extract, Maronie Extract, Mokka Extract, Lily Extract, Ligan (Raimaru) Extract, Lime Extract, Rye Extract, Rakkyo Extract, Shallot Extract, Apple Extract, Gentian Extract Ganoderma (Wicking, Toothpick Nucleus) Extract, Astragalus Extract, Yokuinin Extract, Mini Sasanishiki Extract, Chlorella Bulgaris Extract, Chlorella Pyrenoid Extract, Chlorella Ellipsoidia Extract, Macrocystis pirifera Extract, Yuikiri Extract, Tosakanori Extract, Cypridosa extract, Amakusaori extract, Aoimidori extract, Kawanori extract, Marimo extract, Japanese squirrel extract, Ezoyahaz extract, Habanori extract, Atlantic scallop extract, Cotton bud extract, Aname extract, Japanese squirrel extract, Trolocomb extract, Antarctic extract, Black allame extract, Black cat Ashikonbu extract, Ainu Wakame extract, Tigaiso extract, Ezoi Shige extract, Yabanemoku extract, Trumpet extract, Uganomok extract, Jolomok Kiss, Hiemoku Extract, Tamanashimoku Extract, Honda Walla Extract, Sugi Moku Extract, Bovine Kenori Extract, Susabi Nori Extract, Akebono Mozuku Extract, Salamander Extract, Fusanori Extract, Hosobanamino Hana Extract, Hanaf nori Extract, Itaf nori Extract, Kaginori Extract, Milin Extract, Milin Extract Kikutosaka extract, Ezonameshi extract, Ibaranori extract, Kagibaranori extract, Saidaibara extract, Tachiibara extract, Ogonori extract, Tsurussilamo extract, Hachijogusamodoki extract, Otsunori extract, Red-backed ginseng extract, Natto fungus culture metabolite, Natto Examples include extract, loofah water, birch (white birch) or red pine sap.

(6) Cell activator / metabolic activator Specifically, vitamin A group: retinol or a salt thereof, and derivatives thereof (retinyl linoleate, retinyl linolenate, retinyl oleate, retinyl arachidonate, etc.) Fatty acid esters, etc.), retinal or salts thereof and derivatives thereof, dehydroretinal or salts thereof and derivatives thereof, retinoic acid or salts thereof and derivatives thereof, retinoic acid analogs (4-[[[8- (3,5 -Dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3-methylphenyl) -2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[[8- (4 -Methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methylphenyl) -2-naphthalenyl] carbonyl] amino] Benzoic acid, 4-[[[8- (3,4-dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2,4-dimethylphenyl) -2-naphthalenyl ] Carbonyl] amino] benzoic acid, 4-[[[8- (2-isopropylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-ethylphenyl) -2-naphthalenyl ] Carbonyl] amino] benzoic acid, 4-[[[8- (2-fluorophenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methoxyphenyl) -2-naphthalenyl ] Carbonyl] amino] benzoic acid, 4-[[(8-benzyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[(E) -2- (8-phenyl-2-naphthalenyl) propenyl] benzoic acid ), Retinoic acid derivatives (4-hydroxyphenylretinamide), retinoid analogs (4-[[(5,6-dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5,8- Trimethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[( 5,6-dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) -Carbonyl] amino] benzoic acid, 4- (E)-[2- (5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) -1-propenyl] benzoic acid, 4-[[ (5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) oxy] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2) -(Naphthalenyl) carbonyl] amino] repose Acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] oxy] benzoic acid, 4-[[5,6-dihydro-5,5-dimethyl -8- (2-Fluorophenyl) -naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5,6-trimethyl] -8-phenyl-2- (naphthalenyl) carbonyl] Amino] benzoic acid, 4-[[((5,6-dihydro-5,5,7-trimethyl-8-phenyl-2-naphthalenyl) carbonyl) benzoic acid, 4-[[(E)-(5,6- Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] vinyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl ] Sulfamil] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] sulfamyl] carbonyl] benzoic acid, 4-[[(5,6-dihydro- 5,5-Dimethyl-8-fe Nyl) -2-naphthalenyl] ethyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] thiocarbonyl] amino] benzoic acid, 4- [ [[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] methyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8 -Phenyl) -2-naphthalenyl] methyl] oxy] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthenyl] oxy] methyl] benzoic acid, 4 -[[[((5,6-dihydro-5,5-dimethyl-8- (2,4-dimethylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[((5,6- Dihydro-5,5-dimethyl-8- (4-methylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-Naphthalenyl] ethyl] repose Acid 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] sulfamyl] methyl] benzoic acid, 4-[[(5,6-dihydro-5,5 -Dimethyl-8-phenyl) -2-naphthalenyl] methyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] amino] thiocarbonyl ] Benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] sulfamyl] benzoic acid, 4-[[[((5,6-dihydro- 5,5-dimethyl-8-phenyl-2-naphthalenyl] amino] methyl] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] Amino] -2-hydroxybenzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-nitrobenzoic acid, 4- [ [[(5,6-dihydro- 5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-fluorobenzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2-) Naphthalenyl] carbonyl] amino] -2-methoxybenzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8- (2-naphthalene)]-2-naphthalenyl] carbonyl] amino] benzoic acid 4-[[(5,6-dihydro-8-phenyl-2-naphthalenyl) carbonyl] aminobenzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl ) Carbonyl] amino] -3-fluorobenzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) carbonyl] amino] -3-methylbenzoic acid, 4- [[(5,8,10,10a-Tetrahydro-10,10-dimethyl-9-phenyl-2-anthracenyl) carbonyl] amino] benzoic acid, 4-[[(1,1-dimethyl-3-phenyl-1H1 -In -5-yl) amino] carbonyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-inden-5-yl-oxymethyl) benzoic acid, 4- [2- (1,1 -Dimethyl-3-phenyl-1H-inden-5-yl) vinyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-indene-5-carbonyl) amino] benzoic acid), carotene or Salts thereof and derivatives thereof (α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthine, lutein, zeaxanthin, isozeaxanthin, rhodoxanthine, capsanthin, crocetin and other carotenoids), lycopene or a salt thereof and derivatives thereof, vitamin B Group: Thiamine or salts thereof and derivatives thereof (thiamine hydrochloride, thiamine disulfide, bisbenchamine, bisbutiamine, thiamine monophosphate disulfide, benf Thiamine, chicotiamine, octothiamine, dicetiamine, fursultiamine, prosultiamine, astaxanthinthiamine phosphate diester, etc.), thiamine sulfate, riboflavin or its salts and derivatives thereof (flavin adenine dinucleotide, flavin mononucleotide, riboflavin phosphate) Diester, 1-β-D-ribofuranosyl nicotinamide pyrophosphate diester, 1-β-D-ribofuranosyl nicotinic acid, etc.), pyridoxine or a salt thereof and derivatives thereof (pyridoxine 3,4-dipalmitate, 3 , 4-dicaprylic acid pyridoxine, pyridoxine sulfate diester, etc.), pyridoxal or a salt thereof and derivatives thereof, pyridoxamine or a salt thereof and derivatives thereof, cyanocobalamin or a salt thereof and derivatives thereof, cobalamins (me Lucobalamin, adenosylcobalamin, hydroxocobalamin, aquacobalamin, etc.), folic acid or a salt thereof and derivatives thereof, nicotinic acid or a salt thereof and derivatives thereof, pantothenic acid or a salt thereof and derivatives thereof, biotin or a salt thereof and their Derivatives, choline or salts thereof and derivatives thereof, inositol or salts thereof and derivatives thereof, vitamin C group: ascorbic acid or salts thereof and derivatives thereof, vitamin D group: ergocalciferol or salts thereof and derivatives thereof, Calciferol and its salts and their derivatives (1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanol Cholecalciferol, [1R, 4R] -1α-hydroxy-22-[(1-hydroxy-1-methyl -2-Cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1R, 4S] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-Cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1S, 4R] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-Cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1S, 4S] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, etc.), dihydrotaxosterol or a salt thereof and derivatives thereof, vitamin E group: tocopherol or a salt thereof, and Derivatives thereof, tocotrienol or a salt thereof and derivatives thereof, ubiquinone or a salt thereof and derivatives thereof, vitamin K group: phyto Dione or a salt thereof and derivatives thereof, menaquinone or a salt thereof and derivatives thereof, menadione or a salt thereof and derivatives thereof, menadiol or a salt thereof and derivatives thereof, vitamin F group: linoleic acid or a salt thereof and derivatives thereof, Linolenic acid or a salt thereof and derivatives thereof, arachidonic acid or a salt thereof and derivatives thereof, carnitine or a salt thereof and derivatives thereof, ferulic acid or a salt thereof and derivatives thereof, γ-oryzanol or a salt thereof and derivatives thereof Orotic acid or a salt thereof and derivatives thereof, vitamin P group: rutin or a salt thereof and derivatives thereof, eriocitrin or a salt thereof and derivatives thereof, hesperidin or a salt thereof and derivatives thereof, vitamin L group: anthranilic acid or Its salty And derivatives thereof, adenylthiomethylpentose or a salt thereof and derivatives thereof, vitamin U group: methylmethionine sulfonium chloride or a derivative thereof, valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, Asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine or a derivative thereof (N-octyloxycarbonyl-β-alanyl-L-histidine, N- Dodecyloxycarbonyl-β-alanyl-L-histidine, N- (12-amino-1-oxododecyl) -L-histidine, N-2-ethylhexyloxycarbonyl-β-alanyl-L-histidine hydrochloride, N-he Sadecyloxycarbonyl-β-alanyl-L-histidine, N-octylaminocarbonyl-β-alanyl-L-histidine, N-dodecylaminocarbonyl-β-alanyl-L-histidine, N-dodecylsulfonyl-β-alanyl- L-histidine, N-dodecylamino-oxalyl-β-alanyl-L-histidine, etc.) and their amino acids such as sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid , Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, succinic acid and other α-hydroxy acids, 2-hydroxycarboxylic acids (methyl lactic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid, 2-hydroxyheptanoic acid, 2-hydroxyoctanoic acid, 2-hydroxynonanoic acid, 2-hydroxydecanoic acid, 2-hydroxyundecanoic acid, α-hydro Xylauric acid, α-hydroxymyristic acid, α-hydroxypalmitic acid, α-hydroxystearic acid, α-hydroxyarachidonic acid, cerebronic acid, α-hydroxynervonic acid, mandelic acid, benzylic acid, phenyllactic acid, atrolactic acid, 2- (4′-hydroxyphenyl) -2-hydroxyethanoic acid, 2- (4′-chlorophenyl) -2-hydroxyethanoic acid, 2- (3′-hydroxy-4′-methoxyphenyl) -2-hydroxyethanoic acid, 2- (4'-hydroxy-3'-methoxyphenyl) -2-hydroxyethanoic acid, 3- (2'-hydroxyphenyl) -2-hydroxypropanoic acid, 3- (4'-hydroxyphenyl) -2-hydroxy Propanoic acid, 2- (3 ', 4'-dihydroxyphenyl) -2-hydroxyethanoic acid, glyceric acid, erythronic acid, ribbon acid, arabinonic acid, xylonic acid, lyxonic acid, aronic acid, altronic acid, g Luconic acid, mannonic acid, gulonic acid, idonic acid, galactonic acid, talonic acid, glucoheptonic acid, galactoheptonic acid, tartronic acid, mucinic acid, etc.), polyhydroxycarboxylic acid or hydroxypolycarboxylic acids (gluconolactone, galactonolactone, Glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, sugar acid lactone, pantoyl lactone, glucoheptonolactone, mannonolactone, galactoheptonolactone, etc.), 2-keto acids (glyoxylic acid, methyl 2-ketoethanoate) Benzoylformic acid, methyl benzoylformate, ethyl benzoylformate, phenylpyruvic acid, methyl phenylpyruvate, ethyl phenylpyruvate, 2-ketobutanoic acid, 2-ketopentanoic acid, 2-ketohexanoic acid, 2-ketoheptanoic acid, 2-ketooctaoctane Acid, 2-ketododecanoic acid, methyl 2-ketooctanoate, etc.), quinic acid, isocitric acid, tropic acid, tretocanic acid, 3-chlorolactic acid, cerebronic acid, citramalic acid, agaricinic acid, alloyic acid, pantoic acid, lactobionic acid, Hexulosonic acid, photosensitizer 301, hinokitiol, pantothenic acid or derivative thereof, allantoin, pentadecanoic acid glyceride, linolenic acid or derivative thereof, eicosapentaenoic acid or derivative thereof, docosahexaenoic acid or derivative thereof, estradiol, etenyl estradiol, antiallol or Its glycoside, Liononiresinol or its glycoside, Rhodendendrol or its glycoside, Platyphyronol or its glycoside, Lactone compound (D-glucurono-6,3-lactone, α-D-glucoheptonic -γ-lactone, δ-gluc Lonolactone, α, β-glucooctonic-γ-lactone, L-glonic-γ-lactone, γ-D-galactonolactone, D-saccharide-1,4-lactone, D-saccharide-3,6-lactone, D-ribonic-γ-lactone, α-butyrolactone, γ-butyrolactone, α-octanoic lactone, γ-octanoic lactone, nonanoic lactone, γ-valerolactone, D-manninoic-δ-lactone, D-xyleuric -δ-lactone, D-arabinoic-δ-lactone, stearoyl-δ-gluconolactone, DL-pantolactone, palmitoyl-DL-pantolactone, etc.), 3-hydroxy-3,4-dicarboxy-1,4- Butanolide or its derivative, 6-benzylaminopurine or its derivative, 1,4-diazadicyclooctane, 2,5-dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzo Orchid, rutin, tektrigenin 7-xylosyl glucoside, captopril, alacepril, lisinopril, enalapril, delapril, benazepril, cilazapril, imidapril, quinapril, trandelapril, perindopril, temocapril, losartan, endothelin, galactomannin trimethyl polymer Glycine, proteoglycan, lactic acid bacteria extract, lactic acid bacteria culture extract, lactic acid bacteria fermented milk extract, bifidobacteria extract, bifidobacteria culture broth extract, bifidobacteria fermented milk extract, placenta extract, ganoderma extract, spleen extract, thymus extract, yeast extract, yeast Culture fluid extract, yeast fermentation extract, filamentous fungus extract, filamentous fungus culture fluid extract, basidiomycete extract, basidiomycete culture fluid extract, bacterial cell disruption extract, bacterial culture fluid extract, culture Human dermal cell disruption extract, red ginger extract, fennel extract, barley extract, barley extract, oakuri higotai (Yeoju leakage, indigo piercing) extract, corn fly Extract, Hypericum perforatum extract, Dutch jellied extract, Dutch honey beet extract, Silkworm extract, Roman chamomile extract, Garcinia extract, Kawarani carrot (blue agate) extract, Kakiran extract, Quillaja extract, Kinlan extract, Ginkgo biloba extract, Calendula extract, Sakaneran (Ezosacaneran) ) Extract, Sababagin orchid extract, Sawagurumi (Yamatomo) extract, Shimotsuke extract, Shajin extract, Sumomo extract, Japanese walnut extract, Japanese horsetail extract, Pineapple extract, Chinese plover extract, Japanese cypress , Beech extract, physalis (Torone) extract, maitake (maiko) extract, misohagi (senju-na) extract, mukuge (kiso) extract, mukuroji (longevity skin) extract, bean sprout, eucalyptus extract, yukinoshita (tiger ear grass) ) Extract, Suabisimus extract, Lettuce extract, Aloe extract, Ogon extract, Tonka bean extract, Gentianana extract, Burdock extract, Shikon extract, Carrot extract, Hamamelis extract, Hop extract, Yokuinin extract, Odrichos extract, Assembly Extract, Toki Extract, Toki-Senka Extract, Achacha Extract, Hypericum Extract, Cucumber Extract, Papaver Extract, Rosemary Extract, Parsley Extract, Sanadagusa Extract, Fukurin Amiji Extract, Gobble Comb Extract, Oyster Comb Extract, Onikobue Examples include kiss, gohei comb extract, nagacombu extract, pea comb extract, large dwarf extract, rattle extract, flatfish extract, benimozuku extract, hosobenimozuku extract, kagekinori extract, ezotosaka extract, silamo extract, birch extract and the like.

(7) Antioxidants Specifically, ascorbic acid or a salt thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl hydroxyprophosphate, 5- o-α-D-Glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate Calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L -Ascorbic acid sulfate aluminum Nium salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyranosyl -L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl-L -Ascorbic acid, 6-o-alkylascorbic acid phosphate potassium salt, 6-o-alkylascorbic acid phosphate calcium Um salt, 6-o-alkyl ascorbic acid phosphate barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o-alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl ascorbine Acid phosphate ester diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine Salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate Cholesterol ester, L-ascorbyl palmitate, L-isopalmitate Scorbyl, L-ascorbyl dipalmitate, L-ascorbyl diisopalmitate, L-ascorbyl stearate, L-ascorbyl isostearate, L-ascorbyl distearate, L-ascorbyl diisostearate, L-ascorbyl myristate, isomyristate L-ascorbyl, dimyristic acid L-ascorbyl, diisomyristic acid L-ascorbyl, 2-ethylhexanoic acid L-ascorbyl, di-2-ethylhexanoic acid L-ascorbyl, oleic acid L-ascorbic acid, 2-o-α -D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D- Glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitin Ester, L-Ascorbic acid tetralauric acid ester, L-Ascorbic acid tetra-2-ethylhexanoic acid ester, L-Ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, Lu, L-ascorbine Acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L -Ascorbyl triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl]- 4'-acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphate diester, ascorbic acid Cytol-binding derivatives, ascorbic acid phosphoramide derivatives, ascorbic acid arbutin conjugates, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivatives, ascorbic acid sialic acid derivatives, etc.), stearates, tocopherols or salts thereof and derivatives thereof (α-tocopherol, β -Tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate, tocopherol succinate, tocopherol Linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tokov Lyl glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α- Tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ -Tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L- γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- (sulfoethylamino) -3- (α-tocopheryl-6 -Iroxy) propan-2-ol 1- (carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl ] Cysteine, S- [3- (α-Tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy)- 2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol) , Γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orote Dihydropyridine derivatives (methyl-3-phenyl-2-propenyl 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) pyridine-3,5-dicarboxylate and its salts), Benzochroman derivative, nordihydrogua ceretenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, coenzyme Qn (n = 7-10), pyrroloquinoline quinone, propyl gallate, Sesamol, sesamorin, gossypol, maritimaine, sulfretin, xanthene-2,7-diols, caffeoylquinic acids, propolis, carotenoids (α-carotene, β-carotene, γ-carotene, lycopene, lutein, violaxanthin, spirolo Xanthine, spheroidene, astaxanthin, etc.), fluorotanni , Akebi extract, Achacha extract, Oolongcha extract, Dutch sweetfish extract, Canola extract, Kumquat extract, Gobaishi extract, Ganoderma (Oldgrass) extract, Sesame extract, Sesame cell extract, Sesame seeds Extract, rice bran extract, pomegranate extract, salamander extract, pear extract, Daio extract, tomato extract, Nanten extract, Noami (Daisen) extract, Neubara extract, paprika extract, Pistachio extract, loquat extract, betel wax (large garment, coconut) extract, Japanese bursa extract, bokeh (wooden) extract, Hosobao guruma extract, mao (mao) extract, mimosa extract, mebouki extract, himeuma willow extract, willow deer extract, cotton wisteria Mimei Flower) extract, Chlamydomonas extract, a Yukimo extract, Japanese walnut extract, Red-crowned plover extract, Hypericum extract, Hamelis extract, Clove extract, Melissa extract, Enmiso extract, Birch extract, Salvia extract, Rosemary extract, Southern fruit extract, Ginkgo biloba extract, Green tea extract, Clove extract, etc. Can be mentioned.

(8) Reactive oxygen scavenger / radical scavenger Specifically, superoxide dismutase, catalase, glutathione peroxidase, bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or derivatives thereof, gallic acid or salts thereof, and their Derivatives, curcumin or salts thereof and derivatives thereof, transferrin, ceruloplasmin, coenzyme Qn (n = 7 to 10), uric acid, bilirubin, metallothionein, stilbengaloyl glycoside (3,5,4′-trihydroxystilbene 4 '-o-β-D- (6 "galloyl) glucopyranoside, 3,5,4'-trihydroxystilbene 4'-o-β-D- (2" galloyl) glucopyranoside, etc.), chlorogenic acid phospholipid ester, chlorogen Acid sphingosine ester and derivatives thereof, chlorogenic acid glycolipid ester, Acid sugar ester, chlorogenic acid sterol ester, thiazole derivative or salt thereof (2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxyphenyl) thiazole, 2- (3,4-di) Ethoxyphenyl) -4- [3-carboxy-4-hydroxy-5- (2-methyl-2-propenyl) phenyl] thiazole and 2- (3,4-diethoxyphenyl) -4- (3-carboxy-4 -Hydroxy-5-methylphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- (3-carboxy-5-methoxyphenyl) thiazole,), hydroxymatylesinol, allohydroxymatylesinol, hydantoin Derivatives, Akaminoki (logwood) extract, Akamegasiwa (Akabudi) extract, Akamino Akane extract, Akane akane extract, Akane (Root) extract, Hydrangea (hydrangea) extract, Abemaki extract, Fig , Ginkgo biloba extract, Asparagus extract, Plum (Plum) extract, Vulgaris extract, Prunus quercivorus extract, Estragon extract, Enju (Scarlet flower, Satsuma rice) extract, Kashiwa (Salmon tree, coconut leaf) extract , Genus extract, birch extract, birch extract, cucumber extract Extract, Sasa (Amber) Extract, Perilla Extract, Ajizo Extract, Chimmen Diso Extract, Catamen Diso Extract, Peonies (Gakuen) Extract, Quercus Extract, Japanese Quail Extract, Crape Myrtle Extract, Zicopi Extract, Shirakashi Extract, White Clover (Clover) Extract, Horseradish D , Black tea extract, green tea extract, camellia tea extract, tencha (tea) extract, tender eel extract, naniwai rose (gold cherry) extract, peanut (peanut) extract, kei extract, nikkei extract, ceylon nicky extract, yabuni kei (cinnamon) extract, keishi ( (Keishi branch) extract, Nozenkazura (Ryokan flower) extract, lotus (lotus) extract, Chinese cabbage extract, hadakamugi extract, Hanasuge (my mother) extract, Hermanus (maikai flower) extract, rose (rose) extract, barbasco extract, spinach extract, Beech extract, American beech extract, Dog beech extract, European beech extract, Convolvulus extract, Hosobaokera extract, Button (peony) extract, Mallorum extract Extract, Naminohanaekisu, Yukari extract, bombardier Yukari extract, Azusaekisu, basil extract, woodworking (climate) extract, Hime Fuuro extract, lemon grass extract, and the like.

(9) Fat metabolism promoter Specifically, phthalazine derivatives (4-ethyl-1- (β-hydroxyethylamino) phthalazine, 4-N-propyl-1- (β-hydroxyethylamino) phthalazine, 4-N -Butyl-1- (β-hydroxyethylamino) phthalazine, 4-N-butyl-1- (β-hydroxypropylamino) phthalazine, etc.), xanthine derivatives (caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, Diprofylline, proxyphylline and oxtriphyrin, etc.), Aotsuki-rafuji (wooden cocoon) extract, thistle extract, ale thistle extract, mallow thistle extract, scrub thistle extract, noel thistle extract, abalone thistle extract, cacao extract, elcampuri extract, giant crab raft (Prevention) Extract, Gudget (Strawberry) Extract, Karaku Salmon Man Extract Pepper extract ) Extract, cinnamon extract, primrose extract, red ginseng extract, ginseng extract (dragon gall) extract, naginata kouju extract, banana extract, puerh tea (pure tea) extract, plum extract, boufu (windproof) extract and the like.

(10) UV protective agent / UV absorption accelerator Specifically, benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone) -5-sulfonate sodium, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), 1,2-dihydroxy-4- (2-hydroxyethyl) benzene derivatives (1 -(2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) ) -3-Rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (2-acetyl-4- (3,4-dihy)) Loxicinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (2-acetyl-6- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl- 3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (6- (4 -Hydroxy-3-methoxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl)- 1-methoxyethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-hydroxyethyl-3,4-dihydroxybenzene, 1 -(2- (6- (3,4-dihydroxycinnamoyl) -3-xylosyl) glucosyl) Ru-3,4-dihydroxybenzene, 1- (2- (3-allosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- ( 3-glucosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (3-arosyl-6- (3-hydroxy-4-) Methoxycinnamoyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2 -(3- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (2- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4 -Dihydroxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydride Roxybenzene, etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc.), methoxycinnamate derivatives (ethyl paramethoxycinnamate, Isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, di-2-methoxycinnamate mono-2-ethylhexanoate glyceryl, etc.), anthranilic acid derivatives (such as methyl anthranilate) ), Urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyriline Gin derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, pyridoxine derivatives, pyridoxal derivatives, pyridoxamine derivatives, amethoflavone, neosacranin, 6-dehydrocaine, triazine derivatives (4,4 '4 "-(1,3,5-triazine-2,4,6-triyltriimino) trisbenzoic acid tris-2-ethylhexyl etc.), phosphatidyl chromanol derivatives (1,2-dilaurolylglycero-3- Phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-dimyristoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6'-hydroxychroman, 1,2-dipalmitoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl -6'-hydroxychroman, 1,2 -Distearoyl glycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-dialachidonyl glycero-3-phospho-2 '-Hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6'-hydroxychroman, 1-myristoyl-2-palmitoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5' , 7 ', 8'-Tetramethyl-6'-hydroxychroman, 1-myristoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-tetramethyl- 6'-hydroxychroman, 1-palmitoyl-2-myristoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-palmitoyl- 2-stearoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-stearoyl-2-myristoylglycero-3-phospho-2 '-Hydroxyme Til-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-stearoyl-2-palmitoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7' , 8'-tetramethyl-6'-hydroxychroman, etc.), L-carnosine zinc complex, umbelliferone, esculin, benzyl cinnamate, cinoxalate, oxybenzone, dioxybenzone, octabenzone, soribenzone, benzoresorcinol, arbutin, guaiazulene Shikonin, baicalin, baicalein, berberine, neoheliopan, chlorophylls, xanthophylls, escalol, zinc oxide, talc, kaolin, anthracnose (benzoic acid) extract, hub extract, giant clover extract, cassava extract, kawatake extract, islet jellyfish extract , Hassai extract, Spirulina extract AIA Casio extract, funori Nou storm extract, Hime Gelidium extract, high Gelidium extract, Oobusaekisu, Chinorimoekisu, and the like.

(11) Astringents Specifically, succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannins (tannic acid, Hamelian tannins, acer tannins, tetragalloyl glucose, pentagalloyl glucose, hexagalloyl glucose, heptagalloyl glucose, octagalloyl glucose, nonagaroyl glucose, decagalloyl glucose, undecagalloyl glucose, dodecagaro Gallotannins such as ilglucose, telimaglandin I, telimaglandin II, casarictin, peduncraggin, geraniin, isotarkebin, granatin A, granatin B, ketulinic acid, keblagic acid, casuarine, nuphalin, procyanidin -2, ellagitannins such as thiacinensin A, thiacinensin B, etc.), red grape extract, azuki bean (red bean) extract, altea extract, nettle extract, cascarilla extract, kapok extract, guarana extract, ezo strawberry extract, Dutch strawberry extract, shrimp Gara Strawberry Extract, Nawashiro Strawberry Extract, Momiji Strawberry Extract, European Raspberry Extract, Kidachi Aloe Extract, Hawthorn Extract, Kousuihakka Extract, Cowberry (Koshitachi) Extract, Cola Vera Extract, Sugarcane Extract, Sinah Honoki Extract, Honeysuckle (Gin Silver Flower, Shinobifu) Extract , Horsetail extract, Japanese larch extract, elder extract, dandelion extract, centalium extract, white dandelion extract, mouko dandelion extract, vine azuki bean extract , Tsurutsuchiakebi extract, Teuchigurumi extract, Tormentilla extract, Novara extract, Buttercup extract, Hagoromogusa extract, Castor extract, Grape extract, Prunes extract, Veronica extract, Bisnaga extract, Bilberry extract, Manshugurumi extract, Mitsuga wrinkle extract, Myrrh extract, Melissa Examples include extract, witch hazel extract, bay willow extract, latania (chlamelia) extract, lemon extract, and chickpea extract.

(12) Anti-inflammatory agent / interleukin production inhibitor / histamine release inhibitor Specifically, quinolinone derivatives, dibenzooxepin derivatives, thiotroposin, phthalimide derivatives, flurbiprofen, felbinac, bufexamac, suprofen, 1,4 -Diphenylpropylpiperazine derivatives, carxin compounds, chromanol glycosides (2- (α-D-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol), ictamol, indomethacin, kaolin, diphenhydramine hydrochloride , D-camphor, DL-camphor, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, diphenhydramine hydrochloride, clemastine fumarate, cyproheptadine hydrochloride, Acid promethazine, piperazine derivatives, α-D-phenylglycoside derivatives, glycyrrhizic acid or salts thereof and derivatives thereof (α-glycyrrhizic acid, β-glycyrrhizic acid, α-glycyrrhizic acid methyl ester, β-glycyrrhizic acid methyl ester, α- Trisodium glycyrrhizinate, monopotassium α-glycyrrhizinate, dipotassium α-glycyrrhizinate, monoammonium α-glycyrrhizinate, trisodium β-glycyrrhizinate, monopotassium β-glycyrrhizinate, dipotassium β-glycyrrhizinate, β-glycyrrhizic acid mono Ammonium), glycyrrhetinic acid or salts thereof, and derivatives thereof (α-glycyrrhetinic acid, β-glycyrrhetinic acid, stearyl of α-glycyrrhetinic acid, stearyl of β-glycyrrhetinic acid, pyridoxine of α-glycyrrhetinic acid) , Β-glycyrrhetinic acid pyridoxine, α-glycyrrhetinic acid glycerin, β-glycyrrhetinic acid glycerin, 3-succinyloxyglycyrrhetinic acid disodium, etc.), mefenamic acid, phenylbutazone, ibuprofen, ketoprofen, allantoin, calcium pantothenate, pantothenylethyl Panthenol such as ether or salts thereof and derivatives thereof, ε-aminocaproic acid, diclofenac sodium, tranexamic acid or derivatives thereof (trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-nitrobenzyloxycarbonyl Aminomethylcyclohexanecarboxylic acid, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-bromobenzyloxycarbo Ruaminomethylcyclohexanecarboxylic acid, trans-4-m-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methylbenzyloxycarbonylamino Methylcyclohexanecarboxylic acid, sodium trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylate, ammonium trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid Potassium acid, potassium trans-4-p-bromobenzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-m-chlorobenzyloxycarbo Calcium ruaminomethylcyclohexanecarboxylate, trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylate magnesium, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexanecarboxylate monoethanolamine, trans-4-t- Butyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- ( 3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) Chlohexanecarboxylic acid, sodium trans-4-t-butyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylate, trans-4- (p-biphenylisopropyloxy) Carbonylaminomethyl) calcium cyclohexanecarboxylate, trans-4- (3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) magnesium cyclohexanecarboxylate, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid monoethano -Luamine, trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4-methylsulfonylethyloxycarbonyl Ruaminomethylcyclohexanecarboxylic acid, trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) sodium cyclohexanecarboxylate, potassium trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4- (pyridine -4'-methyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexane Potassium carboxylate, trans-4- (pyridine-4′-methyloxycarbonylaminomethyl) cyclohexanecarboxylate sodium, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexane Potassium carboxylate, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylate, etc.), sulfatide, astaxanthin fatty acid diester (astaxanthin dilaurate ester, astaxanthin dimyristate ester, astaxanthin dipentadecanoate ester, astaxanthin diester Palmitic acid ester, astaxanthin dipalmitooleic acid ester, astaxanthin diheptadecanoic acid ester, astaxanthin dielaidic acid ester, astaxanthin diricinoleic acid ester, astaxanthin petrothelinic acid ester, astaxanthin vacsenate ester, astaxanthin eleostearic acid ester, astaxanthin Punicic acid ester, Astaxa Nanthric acid ester, astaxanthin parinalic acid ester, astaxanthin gadoric acid ester, astaxanthin 5-eicosenoic acid ester, astaxanthin 5-docosenoic acid ester, astaxanthin cetolic acid ester, astaxanthin erucic acid ester, astaxanthin 5,13-docosadienoic acid ester, Astaxanthin ceracholic acid ester, astaxanthin decenoic acid ester, astaxanthin steric acid ester, astaxanthin dodecenoic acid ester, astaxanthin dioleic acid ester, astaxanthin distearic acid ester, astaxanthin dieicosapentaenoic acid ester, astaxanthin didocosahexaenoic acid ester, astaxanthin dilinoleic acid ester, Astaxanthin Giri Renates, astaxanthin diarachidonic acid esters, etc.), astaxanthin diglycerophosphates (astaxanthin diglycerophosphate, astaxanthin lyserophosphate palmitate, astaxanthin lyserophosphatidylcholine palmitate, astaxanthin lyserophosphatidylcholine DHA, astaxanthin lysero Phosphatidylinositol palmitic acid, astaxanthing lyserophosphatidylinositol DHA, astaxanthing lyserophosphatidylinositol linoleic acid, astaxanthing lyserophosphatidylcholine linoleic acid, steviol glycosides, benzimidazole derivatives (1- (2-ethoxy) Ethyl) -2- [1- (2- (4- (1- (4,4-dimethyl-2-oxazolin-2-yl)- 1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- (4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidine- 1-yl) ethyl) phenyl] -2-methylpropanoic acid, ethyl 2- [4- (2- (4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl ) Phenyl] -2-methylpropanate, 1- (2-ethoxyethyl) -2- [1- (2- (4- (1,1-dimethyl-2-hydroxyethyl) phenyl) ethyl) piperidine-4- Yl] -1H-benzimidazole, 1- (2-hydroxyethyl) -2- [1- (2- (4- (1- (4,4-dimethyl-oxazolin-2-yl) -1-methylethyl) Phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- (4- (1- (2-hydroxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl ) Fe Ru] -2-methylpropanoic acid), alanine derivatives or salts thereof (N- {3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5 -Carbonyl} -L-alanine, N- {3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl} -2-methylalanine, N- {3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl} -N-methyl-L-alanine etc.), thiazoline derivatives or Its salt (3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid, 4-isobutyl-3-methyl-2- [4- (3-Trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-ca Rubonic acid, etc.), chlorpheniramine maleate, diphenhydramine hydrochloride, diphenylpyraline hydrochloride, carbinoxamine maleate, hydrocortisone butyrate, sulfated acid mucopolysaccharide or salt thereof, sulfated dextran or salt thereof, fluoromethylhistidine or hydrochloride salt thereof, Histidine methyl ester or its hydrochloride salt, licorice extract, chicory extract, age extract, propolis, eye (Aiba) extract, asenyaku (Asenyaku) extract, avocado extract, amadokororo (tamatake) extract, amiga lily extract, baimo (shellfish mother) Extract, igakozorina (ground bile head) extract, ibukitoranoo extract, turmeric (depressed gold) extract, echina (hosobamurasakibarengiku extract), oren (yellow chain) extract, oguruma (turned over) extract, hypericum (young brother cut grass) extract, sea urchin extract , Oren Extract, cassia extract, chamomile extract (weed) extract, kawamidori extract, cormorant mugwort (bamboo chin moth) extract, watercress extract, kenashi sartorii rose (earthen soil, mountain return) extract, gentian extract, koki-sekoku extract, kakuhon (bamboo shoot, carp bonito) extract, Koryo Kyo (Kora Kaki) Extract, Gosho Strawberry (Cover Bonsai) Extract, Psychiaran Extract, Cherries Extract, Salvia (Sage) Extract, Diquitaris Extract, Linden Extract, Salamander Extract, Indian Bodge Extract, Shukushamitsu (Sanjin, Shredded Sand) ) Extract, juzudama extract, shirominanten (southern honey) extract, licorice ivy extract, s. Extract, Tachikaku Sou (Marika) Extract, Tamazaki Rakuji Extract, Tonin Extract, Chigaya Extract, Toga (Winter Eggplant) Extract, Dokudami (10 Medicines) Extract, Parsley (Netherlands Jelly) Extract, Hanabishi (Satsurishi, Shishitsuri) Extract, Hamasuge (Incense) (Bushi) extract, Hishi (Hishimi) extract, Bellows oyster extract, Japanese pod extract (South rattan) extract, Bundou (mung bean) extract, Sandalwood extract, Butcher bloom extract, Pansy extract, Hosoba-Aragiku extract, Mizurutennansho ( (Tennan star) extract, pheasant (fruit) extract, miracle fruit extract, mulberry extract, peach (peach) extract, cornflower extract, yachi willow extract, mistletoe (willow parasite) extract, yabukouji (purple gold beef) extract, sagebrush extract, mugwort ) Extract, Rosemary (Mannenrou) Kisses, Scots wings extract, Jujusmo extract, Tamajusmo extract, Mizojusmo extract, Urushigusa extract, Siwahige extract, Akamok extract, Togemoku extract, Akaba extract, Maruba akaba extract, Harigane extract, Dulse extract, Una extract, Belladonna extract, Hoonoki Extract, Harunire (crusted skin, white skin, cocoon leaf) extract, Aozzuran extract, Sakaneran extract, Sasabaginran extract, Chinese cabbage extract (including varieties and origin species) extract, Valerian extract, Primrose extract, Nematode extract, Gyoen extract , Honeysuckle extract, touki extract, fennel extract, peppermint extract, and the like.

(13) Antiseborrheic agent Specifically, chroman derivatives, pyridoxine or salts thereof and derivatives thereof, pyridoxal or salts thereof and derivatives thereof, pyridoxamine or salts thereof and derivatives thereof, sulfur, Asa (aspen) extract , Nettle extract (continuous), Dutch mustard (watercress) extract, valerian extract (valerian root) extract, clematis extract, bear sebassikis, scallop extract, rosewood extract, horse chestnut extract, soybean (soybean) extract, Tokinsenka (marigold) Examples include extract, Chinese yam extract, yam extract, nosen-halen extract, Japanese cypress poppy (sect winter flower, winter winter leaf) extract, japonica extract, giant kelp extract, hijirimen extract, proboscis extract, hyus banori extract and the like.

(14) Antibacterial agents Specifically, acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T , Salicy powder, iodine compound, iodoform, 1-alkylcarbapenem compound, N-substituted azepane derivative or salt thereof, sorbic acid or salt thereof, propionic acid or salt thereof, salicylic acid or salt thereof, dehydroacetic acid, parahydroxybenzoic acid ester 2-keto-3-deoxyoctanoic acid fatty acid ester, inositol deoxy derivatives (such as quercitol), inositol unsaturated derivatives (such as chonditol), inositol dimethyl ether, methyl inositol, inositol Ether, inosamine, deoxyinosadiamine, shikimic acid, quinic acid, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol , Thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc Pyridione, chlorobutanol, isopropylmethylphenol, elemol, tiveverol, patchouli alcohol, nonionic surfactant (polyoxyethylene lauryl ether, poly Xylethylene nonylphenyl ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride) Benzethonium chloride, methyl rosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal violet, jamal, photosensitizer 101, photosensitizer 201, photosensitizer 401, N-long chain acyl basic amino acid derivatives and acids thereof Addition salt, zinc oxide, hinokitiol, propolis, cucumber extract, agi (Ayu) extract, asunaro extract, alpinia extract, katsudai (Suzukuku) extract, Inubuyu (Honagainbuyu) extract, Aogateto extract, Haribiyu extract, Ayuyu extract, Hagatou extract, Hosonagabiyu extract, Enmeiso extract, Warbler extract, Usbasaicin extract, Hanasaishin extract, Halibut extract, Ominaeshi (defeated sauce) extract Choi extract, Kahoku salamander extract, chamomile extract, linden extract, red linden extract, yellowfin extract, caraway extract, betel extract, kumazasa extract, cranberry extract, grapefruit extract, celosia (chicken crown flower, (Chicken cot) extract, bay bay laurel extract, cinnabar rose (moon flower) extract, copaiba balsam extract, yamazakura extract, edhigashira extract, miyazakura extract, yoshino cherry extract, casamikura extract, kanzakura extract, Sugar beet extract, white pepper extract, scabbard extract, birch extract, cinnamon extract, sorrel extract Sowka (grass) extract, onion extract, chicory extract, Korean senile (蕪 夷) extract, tsuruna (apricot) extract, tokon (root) extract, leek (coconut) extract, leek extract, peach extract, patchouli extract, Astragalus extract, cypress extract, pimenta extract, Acer palmatum extract, Blackberry extract, Hop extract, Makuri (sea herb) extract, Magnolia sprenger extract, Mizokakushi (half) Lotus) extract, bee extract, purple (purple) extract, moso bamboo extract, Pokeweed (commercial and commercial) extract, yucca extract, euglena extract, lavender extract, forsythia extract, syringen extract, prunus nomata extract, tochaka (yahazuzumata) extract, red-bellied extract, anaaosa extract, human rush extract, hirohano Listed are: Human rush extract, Ushua rush extract, Iroro extract, Ishige extract, Alame extract, Tamai taki extract, Tambanori extract, Katanori extract, Sakuranori extract, Fujimatsumo extract, Kawamokuzuku extract, Aokawa Mozuku extract, Himekawa Mozuku extract, Yakuchi extract It is done.

(15) Blood flow promoter / vascular stimulator Specifically, tocopherol or a salt thereof and a derivative thereof, tocotrienol or a salt thereof and a derivative thereof, cephalanthin, carpronium chloride, an eugenol derivative (acetyleugenol, methyleugenol, methylisoeugenol) , Ethyl eugenol, ethyl isoeugenol, eugenol salicylate, etc.), minoxidil, pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, mint oil, L-menthol, camphor, benzyl nicotinate, cinnarizine, trazoline, acetylcholine, verapamil , Ikutamol, α-borneol, cyclandrate, nonylic acid valenylamide, capsaicin, gingerone, assembly extract, garlic extract, carrot extract , Aloe extract, Gentian extract, Toki extract, Ashitaba (Tomorrow) extract, Arnica extract, Ukiyagara (Sanryo) extract, Himewiku extract, Citrus unshiu (Chest) extract, Toucan beetle (coconut) extract, Oyster extract, Persimmon extract, Kina extract, goldfish extract, pine moth (horse whip grass) extract, gubijinsou extract, kohone (river bone) extract, burdock (beef bowl, beef coconut) extract, scallop (Yamabachi) extract, syringen extract, ginger (ginger) extract, Shobu (bamboo root, radish) extract, hawthorn extract, sea bream (Otaku) extract, Daidai (orange peel) extract, tanjin (dansang) extract, thyme extract, chiketsu carrot (bamboo ginseng) extract, tsurudokudami (what neck crab) extract , Carrot (Yoteba ginseng) extract, Capsicum (bansho) extract, Toki (toll) , Scotchworm extract (Sadako), Natsumikan extract, elderberry (bone graft) extract, hazelnut (coconut) extract, Hashiridokoro (roth root) extract, mint (light load, thin load leaf) extract, Hamabou Fu (beach wind) extract, Higotai extract , Fujimodoki (Chojizakura, Camellia) extract, Black currant extract, Bodaiju (Aoki tree) extract, Merirot extract, Yuzu extract, Loquat extract, Japanese jelly extract, Hibiscus extract, Rosehip extract and the like.

(16) Antiandrogens Specifically, follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendron, 4 ', 5,7-trihydroxy-8-prenylflavanone, 4', 5,7-tri Examples include hydroxy-8-prenyl flavone, 3,3 ′, 4 ′, 5,7-pentahydroxy-8-prenyl flavone, nicorandil, cyclosporic acid and the like.

(17) Inhibitors of structural proteolytic enzymes (elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme, etc.) / Structural proteolytic enzyme expression inhibitor Specifically, adenine derivatives (butanetriol-9-adenine and its phosphate adduct, propanediol-9-adenine and its phosphate adduct, pentanetriol-9-adenine and its Phosphoric acid adducts, carbostyril derivatives or salts thereof, dicarboxylic acids (glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, 1,9-nonamethylenedicarboxylic acid, 1,10-decamethylene Dicarboxylic ), Rosmarinic acid, ursolic acid, oleanolic acid, hydroxamic acid derivative, esculetin derivative, anthocyanidins, nordihydroguaiaretech acid, 20-carboxy-16-hydroxy-21-nor-5 α-7,9 (11)- Lanostadien-3,24-dione, ubiquinone, plataquinone, yuglone, shikonin, quinizarin, alizarin, abietin, levopimar, betulin, α-amylin, catechin compounds (catechin, epigallocatechin, epigallocatechin gallate, epicatechin, epicatechin gallate, Catechin rhamnopyranoside catechin, etc.), diisopropyl fluorophosphate, (2R, 6R) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylic acid Dimethyl, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzylo Ci-4-hydroxyheptanedicarboxylic acid-1,7-diamide, (2R, 6R) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2R, 6R) -2,6-Dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2R, 6R) -2,6-dibenzyloxy-4- (tert- Butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy -4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R)- 2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R)- 2,4,6-trihydroxyheptane-1,7-dicarboxylic acid diamide, N, N'-bi [(1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, (2S, 6S)- 2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate, (2S, 6S) -2,6-dihydroxy-4- (tert-butyldimethyl) Silyloxy) heptane-1,7-dicarboxylate, (2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2S, 6S) -2,6-Dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N'-bis [(1S, 2R) -2-hydroxyindan-1- Yl]-(2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R)- 2-Hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy 4-hydroxyheptane-1,7-dicarboxylic acid diamide, 3-[[4- (4-fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclopentyl) -amino] -propionic acid, 4- [4- (4-Fluorophenoxy) -benzenesulfonylamino] -tetrahydropyran-4-carboxylic acid hydroxyamide, 4- [4- (4-chlorophenoxy) -benzenesulfonylmethyl] -tetrahydropyran-4-carboxylic acid hydroxyamide, 3 -[[4- (4-Fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclobutyl) -amino] -propionic acid, 4- (4'-chlorobiphenyl-4-yl) -2- [2- (1,3-dioxo-1,3-dihydroisoindol-2-yl) -ethyl] -4-oxobutyric acid, {1- [4- (4-fluorobenzyloxy) -benzenesulfonyl] -2-hydroxycarbamoyl Pipette Gin-3-yl) -carbamic acid isopropyl ester, 2- [4- (4-fluorophenoxy) -benzenesulfonylamino] -N-hydroxy-2-methylfuropionamide, 3- [4- (4-fluorophenoxy) ) -Benzenesulfonyl] -2, N-dihydroxyfuropionamide, 3- (4-phenoxybenzenesulfonyl) -7-oxabicyclo [2.2.1] heptane-2-carboxylic acid hydroxyamide, (4-benzylbenzyl)- [2- (2,2-dimethyl-1-methylcarbamoylpropylcarbamoyl) -4- (4′-fluorobiphenyl-4-yl) -butyl] -phosphinic acid, 2-amino-3- [4- (4- Fluorophenoxy) -benzenesulfonyl] -N-hydroxypropionamide, and N-hydroxy-2- (4-phenylpiperidine-1-sulfonyl) -acetamide, Iris japonicum extract, Nepenthes (summer hay) extract, o Bananas beetle (Banaba) extract, Barley hawthorn extract, Hawthorn (Yamako) extract, Calahoo (Koh-Pak) extract, Guava extract, Garbage (Gomicho) extract, Shazenso extract, Atlantic rose extract, Hypericum perforatum extract, Octopus (breeding) extract , Hina Taiko Kozuchi (cow knee) extract, Honoki (Japanese Koshoku, Park) extract, American grape extract, European grape extract, Yama grape extract, Mandarin extract, Misaki psycho (Shibahu) extract, Ogon extract, Hypericum extract, Clara extract, Mulberry extract , Cinnamon extract, gentian pepper extract, comfrey extract, salvia extract, chickfish extract, bodaige extract, button pi extract, Aozulan extract, sacanelan extract, sasabagin orchid extract, varieties and origin species No) extract, Aono agave extract, sisal hemp extract, Adenophortriphylla extract, and the like.

(18) Structural protein synthesis promoter Specifically, ethanolamine derivatives, pentoxyphyllin, serine derivatives, geraniol, crocetin, methyl 4- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-4- (3,5,5-trimethylhexyloxy) methyl benzoate, methyl 4-cyclohexylmethoxy-2-hydroxybenzoate, methyl 4- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4- (3,7- Methyl dimethyl-6-octenyloxy) -2-hydroxybenzoate, ethyl 3- (2-ethylhexyloxy) -5-hydroxybenzoate, methyl 5- (2-ethylhexyloxy) -2-hydroxybenzoate, 2- Hydroxy-5- (3,5,5-trimethylhexyloxy) methyl benzoate, methyl 5- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4-N-hexyloxy-2-hydroxy Methyl benzoate, methyl 2-hydroxy-4-N-octyloxybenzoate, methyl 4-N-decyloxy-2-hydroxybenzoate, methyl 5-N-hexyloxy-2-hydroxybenzoate, 4- (2- Ethylhexyloxy) -2-hydroxybenzoic acid, 2-hydroxy-4- (2,5,5-trimethylhexyloxy) benzoic acid, 4-cyclohexylmethoxy-2-hydroxybenzoic acid, 4- (2-cyclohexylethoxy)- 2-hydroxybenzoic acid, 4- (3,7-dimethyl-6-octenyloxy) -2-hydroxybenzoic acid, 3- (2-ethylhexyloxy) -5-hydroxybenzoic acid, 5- (2-ethylhexyloxy) ) -2-Hydroxybenzoic acid, 5- (2-ethylhexyloxy) -2-hydroxybenzoic acid, 2-hydroxy-5- (3,5,5-trimethylhexyloxy) benzoic acid, 5- (2-cyclohexylethoxy) ) -2-Hydroxybenzoic acid, 4-N-hexyl Oxy-2-hydroxybenzoic acid, 5-N-hexyloxy-2-hydroxybenzoic acid, 2-hydroxy-4-N-octyloxybenzoic acid, 4-N-decyloxy-2-hydroxybenzoic acid, N- (2 -Hydroxyethyl) -4- (2-ethylhexyloxy) -2-hydroxybenzamide, N-ethyl-4- (2-ethylhexyloxy) -2-hydroxybenzamide, 2-acetoxy-4-cyclohexylmethoxybenzoic acid, 4- (2-Ethylhexyloxy) -2-hydroxybenzoic acid sodium salt, 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid methyl ester, 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate, 5-{(2E) -3,7 dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate Ethyl, 3-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate, 3- (2E) -3,7-dimethyl-2,6-octadienyloxy} -5-hydroxybenzoate, 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy}- Ethyl 3-methoxybenzoate, 4-{(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy} -2-hydroxymethyl benzoate, 4-{(2E)- 3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid (2E) -3,7-dimethyl-2,6-octadienyl, 4-{(2E) -3,7-dimethyl- 2,6-octadienyloxy} -2-hydroxybenzoic acid, 5-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid, 3-{(2E ) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid, 3-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -5-hydroxy Benzoic acid, 2-hydroxy-4-{(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy} benzoic acid, 4-{(2E) -3,7-dimethyl - 2,6-octadienyloxy} -3-methoxybenzoic acid, 2-acetoxy-4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} benzoic acid, N- (2- Hydroxyethyl) -4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzamide, 4-{(2E) -3,7-dimethyl-2,6-octa Dienylamino} -2-hydroxybenzoic acid, dimethyl-2,6-octadienyloxy} benzoic acid, N- (2-hydroxyethyl) -4-{(2E) -3,7-dimethyl-2,6 -Octadienyloxy} -2-hydroxybenzamide, 4-{(2E) -3,7-dimethyl-2,6-octadienylamino} -2-hydroxybenzoic acid, 3-dodecyloxybenzoic acid, 3- (12-hydroxydodecyloxy) benzoic acid, 4-dodecyloxybenzoic acid, 4- (12-hydroxydodecyloxy) benzoic acid, 3- (12-hydroxyoctadecyloxy) benzoic acid, 4- (12-hydroxyocta Siloxy) benzoic acid, 3- (11-hydroxyundecyloxy) benzoic acid, 4- (11-hydroxyundecyloxy) benzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadi Enyloxy) benzoic acid, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, 3-[(2E, 6E) -3,7,11-trimethyl-2, 6,10-dodecatrienyloxy) benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4- [3,7- Dimethyl-9- (2,6,6-trimethyl-1-cyclohexen-1-yl) -2,4,6,8-nonatetraenyloxy] benzoic acid, 4- [3,4-dihydro-2,5 , 7,8-Tetramethyl-2- (4,8,12-trimethyltridecyl) -2H-1-benzopyran-6-oxy] benzoic acid, 4-[(2E, 6E) -3,7,11- Trimethyl-2,6,10-dodecatrienyloxy] benzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzamide, 4- (2-methyl 2-butenyloxy) benzamide, 4- (2-ethylhexyloxy) benzamide, 4-dodecyloxybenzamide, 4- (12-hydroxydodecyloxy) benzamide, 4- (12-hydroxyoctadecyloxy) benzamide, 4- (11 -Hydroxyundecyloxy) benzamide, 4- (10-hydroxydecyloxy) benzamide, 4-isostearyloxybenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11- Trimethyl-2,6,10-dodecatrienyloxy] benzamide, N, N-dimethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzamide N, N-di [(2E) -3,7-dimethyl-2,6-octadienyl] -4-aminobenzamide, 4- [N'-methoxycarbonyl-N-[(2E) -3,7-dimethyl -2,6-octadienylamino] benzamide, 4- [N-acetyl-N-[(2E) -3,7-dimethyl -2,6-octadienyl]] aminobenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2 -Hydroxybenzamide, N, N-diethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, pea extract, Tosakamodoki extract , Ikanoashi Extract, Hosobonori Extract, Novonori Extract, Igis Extract, Keigi Extract, Harigigi Extract, Hanagigi Extract, Usuba Watanagi Extract, Moroitogusa Extract, Fumoitusa Extract, Hanayagi Extract, Willow Tree Extract, Moyuyurena Extract Examples include Kori extract, Prunus extract, Sasabayana Ginori extract, horseradish extract, merbou extract and the like.

(19) Mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitors Specifically, anacardic acid or its derivatives (6-pentadecatrienylsalicylic acid methyl ether, 6-pentadecatrienylsalicylic acid ethyl ether, 6 -Pentadecatrienyl salicylic acid propyl ether, 6-pentadecatrienyl salicylic acid butyl ether, 6-pentadecatrienyl salicyl alcohol methyl ether, 6-pentadecatrienyl salicyl alcohol ethyl ether, 6-pentadecatrienyl salicyl alcohol propyl ether 6-pentadecatrienyl salicyl alcohol butyl ether, 6-pentadecatrienyl salicylaldehyde methyl ether, 6-pentadecatrienyl salicylaldehyde ethyl ether, 6-pentadecatrienyl salicyl aldehyde Dopropyl ether, 6-pentadecatrienyl salicylaldehyde butyl ether, 2-methyl ether-6-pentadecatrienyl cinnamic acid, 2-ethyl ether-6-pentadecatrienyl cinnamic acid, 2-propyl ether-6 -Pentadecatrienyl cinnamate, 2-butyl ether-6-pentadecatrienyl cinnamate, 2-methyl ether-6-pentadecatrienyl cinnamate alcohol, 2-ethyl ether-6-pentadecatrienyl cinnamate Skin alcohol, 2-propyl ether-6-pentadecatrienyl cinnamon alcohol, 2-butyl ether-6-pentadecatrienyl cinnamon alcohol), polyisoprenylated benzophenone derivatives (garcinol, isogarcinol, xantho) Thymol, isoxanthothymol, gucciferon, etc.), Ikarisou extract, Yachima Taikiso (Yinyokukaku) extract, Narukoyuri extract, Kajikarumabanarukoyuri (Yellow spirit) extract, Oregano extract, Oshida extract, Onji extract, Spruce extract, Crow peony (Half summer) extract, Pheasant (fruit) extract, Japanese wolfberry (Bone skin) extract, Goshuyu extract, Senega extract, Sendan extract, Tamarind extract, Tarragon extract, Korean radish (Dahi) extract, Bee extract, Daisies extract, Milobaran extract, Himekuma willow extract , Mockin extract, Laurel extract, Yabusotatsu extract, Anaaasa extract, Macrocystis integolifolia extract, Neocitus Ruetkeana extract, Hiluxa extract, Oatweed extract, Caterpillar extract, Yatabegusa extract, Spotted rush extract, Ezo Nomata extract, Togetu no Mata extract, Fusaiwa mushroom extract, Hanemo extract, Mill extract, Chrome mill extract, Nagamil extract, Hiramil extract, Matsumo extract, Okinawa mozuku extract, Mozuku extract, Fukuronori extract, Kajime extract, Fukurofunori extract, Makhunori extract, Grape leaf extract, Sunflower extract, Astragalus extract etc. are mentioned.

(20) Mucopolysaccharide synthesis promoter Specifically, stilbene derivatives or salts thereof, morgin or salts thereof and derivatives thereof, N-acetylglucosamine, flax extract, cinnamon extract, mulberry extract, scotch extract, breadfruit Extracts Examples of the extract include black beetle extract, nezushinosakamodoki extract, yusora extract, etsukinotosakamodoki extract, nankaitosakamodoki extract, himetosakamodoki extract, and the like.

(21) Intercellular adipogenesis promoter / intercellular lipid state improving agent Specifically, phospholipids (phosphatidylethanol, phosphatidylcholine, phosphatidyltriethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylglycerol, phosphatidylinositol, diacylphosphatidylcholine, Diacylphosphatidylethanolamine, diacylphosphatidylinositol, diacylphosphatidylserine, 1-cysteinylphosphatidic acid, 2-cysteinylphosphatidic acid, 1-glutathionylphosphatidic acid, 2-glutathionylphosphatidic acid, 1-azelaoylphosphatidic acid 2-azela oil phosphatidic acid, 1-hydroxyacyl phosphatidic acid, 2-hydroxyacyl phosphatidic acid, ceramide, glucosi Ceramide, galactosylceramide, cerebroside, phosphatidylglucosylacylglycerol, N-oleoylsphingosine, N- (12-hydroxyoctadecanoyl) sphingosine, N- (16-hydroxyhexadecanoyl) sphingosine, N-salicyloylphytosphingosine, Sphingomyelin, soybean lecithin, egg yolk lecithin, etc.), sterins (cholesterol, dihydrocholesterol, cholesteryl stearate, cholesteryl hydroxystearate, macadamia nut oil fatty acid cholesteryl, β-sitosterol, stigmasterol, campesterol, ergosterol, 5-dihydro Ergosterol, phytosterol, 25-hydroxycholesterol, 26-hydroxycholesterol, 19-hydroxycholesterol 22-ketocholesteroloxime, 6-ketocholesterol and 7-ketocholesterol or their derivatives), N-acetylneuraminic acid (sialic acid), N-glucosolneuraminic acid, gangliosides (galaose, ganglytriaose, Ganglitetraose, globotetraose, neolactotetraose, neolactohexaose, neolactooctaose, etc.), oligosulfated hyaluronic acid, hydroxytamoxifen compounds, glyceroglycolipids, pentoxyferrin, 3-deazaadenosine, Carboxamide derivatives, inositol polyamines, sialic acid, triterpenic acid derivatives, lactose, lactosamine derivatives, sulfated chitin derivatives, albumin, ginseng extract, tochiban ginseng extract, sea cucumber extract, red lily extract Hakata lily extract, poppy extract, and the like.

(22) Keratolytic agent / stratum corneum exfoliation accelerator Specifically, tropolone and its derivatives, resorcin, lactic acid, urea, salicylic acid, guanidine, ethanolamine, kikarasuuri (Gurone) extract, fenugreek extract, wisteria bean (shado) Extract, lentil extract, chickpea extract, mungbean extract and the like.

(23) Plasminogen activator antagonist inhibitor Specific examples include rabbit daisy extract, canamgra extract, caladium extract, raspberry extract and the like.

(24) Maillard reaction inhibitors Specifically, aminoguanidine, flavanones (naringin, naringenin, naringin, naringenin, liquiritin, liquiritigenin, digallic acid, luteoic acid, ellagic acid, chlorogenic acid, glucogallin, tetralin, hamamelitannin Tannic acid, tannic acid, tannic acid, geraniin, gallic acid, galloyl gallic acid, ellagitannin, hexagalloyl glucose, heptagalloyl glucose, tetragalloyl glucose, trigalloyl glucose, pentagalloyl glucose, digalloyl quinic acid, trigalloyl kinin Acid), 2-hydroxyphenylalkylamine derivatives or salts thereof, phenylpropenoic acid derivatives (3- [2,3-bis (methoxymethoxy) phenyl] propenoic acid, 7- (4-hydroxy-3-methoxyphenyl) hepta- 2,4,6- Trienoic acid, 3- (3,5-dimethoxy-4-hydroxyphenyl) propenohydrazide, N'-isopropylidene-3- (2-methoxyphenyl) propenohydrazide, etc.), citric acid or a salt thereof, ginger (Ishizuchi) Root) extract, sandalwood extract, red-crowned wrinkle extract, persimmon (including salmon) extract, mulberry extract, Hypericum perforatum extract, camellia extract, garega extract, yaba santa extract, rosehip extract, asunaro extract, itadori extract, icha yak extract, kei Kanka extract, Birch extract, Hawthorn extract, Achillea millefolium extract, Cod extract, Dokudami extract, Tormentilla extract, Bakumondo extract, Hiba extract, Grape extract, Michiyanagi extract, Mukuroji extract, Karin extract, Mokka extract, Roman kami Reekisu, and the like.

(25) Testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promoter Specifically, γ-amino-β-hydroxybutyric acid esters (γ-amino-β-hydroxybutyric acid methyl ester, γ-amino) -β-hydroxybutyric acid ethyl ester, γ-amino-β-hydroxybutyric acid propyl ester, γ-amino-β-hydroxybutyric acid butyl ester, γ-amino-β-hydroxybutyric acid ethylhexyl ester, γ-amino-β-hydroxybutyric acid hexa Decyl ester, γ-amino-β-hydroxybutyric acid lauryl ester, γ-amino-β-hydroxybutyric acid stearyl ester, γ-amino-β-hydroxybutyric acid oleyl ester, γ-amino-β-hydroxybutyric acid benzyl ester, γ-amino -β-hydroxybutyric acid phenyl ester, γ-amino-β-hydroxybutyric acid ethyl glycol ester, γ-amino-β-hydroxy Acid sorbitol ester, γ-amino-β-hydroxybutyric acid polyoxyethylene glycol ester, γ-amino-β-hydroxybutyric acid glycerin ester, etc.), amine oxides (oleyl dimethylamine oxide, stearyl dimethylamine oxide, palmityl dimethylamine oxide) , Myristyl dimethylamine oxide, lauryl dimethylamine oxide, dimethyl lauryl ethoxyamine oxide, dihydroxyethyl lauryl amine oxide, coconut oil alkyl dimethylamine oxide, etc.), alkyl betaines (coconut oil fatty acid amidopropyl betaine, coconut oil alkyl betaine, lauryl dimethyl) Aminoacetic acid betaine, lauric acid amidopropyl betaine, lauryl hydroxysulfobetaine, 2-alkyl-N-carboxymethyl-N-hydroxy Ethyl imidazolinium betaine), pyrimidine N-oxide derivatives (2-amino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-6- (1-pyrrolidinyl) pyrimidine- 3-oxide, 2-amino-4-methyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-6- [1- (4-methylpiperazinyl)] pyrimidine-3-oxide, 2-amino-4- (1-hexahydroazepinyl) -6-methylpyrimidine-1-oxide, 2-amino-4-dimethylamino-6-methylpyrimidine-1-oxide, 2-amino-4-allylamino -6-methylpyrimidine-1-oxide, 2-amino-4-benzylamino-6-methylpyrimidine-1-oxide, 2-amino-4,5-methyl-6-piperidinopyrimidine-3-oxide, 2 -Amino-4-ethyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-5-nitro-6-piperidinopyrimidine-3-io Sid, 2,5-diamino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-5,6-bis (1-pyrodinyl) pyrimidine-3-oxide, 2-amino -4-methyl-5-piperidino-6- (1-pyrrolidinyl) pyrimidine-3-oxide, 2-methyl-4-amino-6-piperidinopyrimidine-3-oxide, 2-methyl-4-amino-5 -Bromo-6- (1-pyrosinyl) pyrimidine-3-oxide, 2-methyl-4-amino-5-nitro-6-piperidinopyrimidine-3-oxide, 2-methyl-4,5-diamino-6 -Piperidinopyrimidine-3-oxide, 2-methyl-4-amino-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-6-piperidinopyrimidine-3 -Oxide monohydrochloride, 2-acetylamino-4-methyl-6-piperidinopyrimidine-3-oxide, 2,4-diamino-6-phenoxypyrimidine-3-oxide, 2,4-diamino-6- ( 2,4-dichlorophenoxy ) Pyrimidine-3-oxide, 2,4-diamino-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitroso-6- (2,4-dichlorophenoxy) ) Pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2, 4-dichlorophenoxy) pyrimidine-3-oxide, 2,4,5-triamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-bromo-6- (2, 4-dichlorophenoxy) pyrimidine-3-oxide, etc.), p-menthane-3,8-diol, monoglyceryl-D-glucoside monotridecanoate, 1-oN-pentadecylglycero-D-glucoside, mono Glycerol sulfate such as pentadecanoic acid glyceride sulfate, monopentadecyl glyceryl ether sulfate, 1-o-hexade -2-o-methyl glycerol, 1-o-octadecyl-2-o-methyl glycerol, 1-o-oleyl-2-o-methyl glycerol, acetylcarnitine or a salt thereof, geranylgeranylacetone, Hydroxamic acid derivatives or salts thereof, gingerone glycosides, benzeneoxyacetic acid derivatives ([5- [2- [1-phenyl-1- (3-pyridyl) methylideneaminooxy] ethyl] -7,8-dihydronaphthalene- 1-yloxy] acetic acid, etc.), isorhamnetin-3-robinobioside, xanthone derivatives, proanthocyanidins (grape seed extract proanthocyanidins, apple-derived proanthocyanidins, pine-derived proanthocyanidins, purified procyanidin oligomers, procyanidin B-1, procyanidin B- 2, procyanidin B-3, procyanidin C-1, etc.), arakashi extract, angelica extract, apricot ( Jin) extract, Hong apricot extract, Ichiyakusou (one herb) extract, Enishida extract, psyllium (car forerunner, car forerunner) extract, Psyllium extract , Chrysanthemum extract, striped chrysanthemum extract, ginseng extract, cuttlefish extract, kukui nut extract, camphor tree extract, kubeba extract, buckthorn extract, snapper extract, snapdragon extract, snapdragon extract, kipi extract, citrus extract, cilantro extract, kobushi extract, Magnolia extract, honeysuckle extract, binankazura extract, pine bush extract, colombo extract, condurango extract, sasanqua extract, sweet potato extract, honeybee jujube ( (Jinjin) Extract, Sandskon (Yamadame) Extract, Potato Extract, Shishigashira Extract, Sanshishi Extract, Coriander Extract, Stevia Extract, Takatodai Extract, Tarayou (Ooba Fuyu Ao, Ichiha Tea, Bitter Tea, Tofu Tea) Extract, Taran extract, Nigaki (Nagi) extract, Nurde (Pyto) extract, Hakama Labosi (bone crushing) extract, Hamakokuren extract, Smoke squirrel extract, Sphagnum extract, Hakogakusa (Reeds) extract, Hyacinth carrot (Participant) Extract, Mangosteen Extract, Myouga Extract, Melaleuca Extract, Yachabushi (Yagar) Extract, Himeya Shabushi Extract, Ooyabaya Shabushi Extract, Yakuso Extract, Yamahanoki (Yamatake) Extract, Longan (Dragon Eye Meat) Extract, Locon (Yoshi, Sone) Extract , Logwood extract, lantana extract, etc. .

(26) Hair matrix growth inhibitor / hair growth inhibitor Specifically, phthalazinones, benzoxazinones, phosphonic acid derivatives, cyproterone, 5α-androstene-3α, 17β-diol, medroxyprogesterone, norethisterone, Examples include Mestanolone, Ichihatsu (primary) extract, Kashiwa extract, Kantou extract, Sanjiko extract, Shiramo extract, Sowjutsu extract, Hitobushi licorice extract, Fritillary extract, Iris japonica extract, Iris extract and Yoremok extract.

(27) Hair swelling / protecting agent Specific examples include ethanolamine, urea, guanidine, silicones, blueberry extract, mango extract and the like.

(28) Odorous substance scavenger Specific examples include inondo extract, Elemi extract, danmar extract, vanilla bins extract, pine extract and the like.

  Specific examples of ingredients derived from plant-based materials used as additives include Aokazura (Seifu-to) extract, Aotenma extract, Akasuguri extract, Aquine (crust) extract, Aguay guassu extract, Abiul extract, Abiurana Extract, yellow sapote extract, ylang ylang extract, phalaenopsis extract, uba tea extract, suzuran extract, unboku extract, elderberry extract, sasayukiyuki extract, sasanoyuki extract, tossed cactus extract, ohia catechu extract, onoelan extract, cynomolgus (Kinshato) extract, karaya extract, garyu extract, kawaratake extract, candelilla extract, canna extract, beetle mint extract, kimenakaku extract, cabbage extract, kiraja saponaria extract, ginsekai extract, kimbusenki , Guapeba vermelha extract, kugenumaran extract, cousberry extract, cutiti river extract, curkrigo latifolia extract, black moth (rescue) extract, cucurian extract, sapotea mariyo extract, salmon berry extract, sarancito (sand indigo) (Sashimi) extract, Sancactus cactus extract, Sansakuyo Sou extract, Shunran extract, Shozukku extract, Shirobanatsuta extract, Cinconacill sylbra extract, Swimberry extract, Star apple extract, Sulgaran extract (Oran) extract, Red pine extract, Seiyo Cypress extract, scallop extract, mistletoe extract, sennin cactus extract, senboku extract, elephant shoot extract, prunus extract, some mono-potato extract, dark sea Cherry extract, Prickly pear extract, Choco nostay extract, Korean mugwort extract, Azalea extract, Azalea extract, Azalea extract (Duckweed) extract, Duberry extract, Clover extract, Tragacanth extract, Triacanthus extract, Nai Zeria berry extract, Rapeseed extract, Plover-dough extract, Pau doce extract, Hakukayumatou extract, Hakuru berry extract, Batata extract, Hamakakiran extract, Balata extract, Harcan orchid extract, Pecan nut extract, Dinosaur extract Extract, Brazilian carrot extract, Braignen extract, Frucereria extract, Blond psyllium extract, Hetsukaran extract, Henken extract, Berry extract, Persair extract, Pervianburg extract, Pele Kia Grandifolia extract, Boysenberry extract, Hosairan extract, Pouteria sapota extract, Pouteria rukuma extract, Hosobabarengiku extract, Whataberry berry extract, Masalan ubaba extract, Masala nuba de ceara extract, Masheira de Boyi extract , Matta Oryo Extract, Mulberry Extract, Green Zapote Extract, Murasaki Corn Extract, Megacansa Opuntica Extract, Mokukirin Extract, Momijidaio Extract, Morello Cherry Extract, Yakawa Murasaki Imo Extract, Cornflower Extract, Rurita Thistle Plant extracts such as Xinjiang Indigo Ginger Extract, Red Currant Extract, Red Pitaya Extract, Lemongrass Extract, Wax Palm Extract, Logan Berry Extract, etc. I can get lost.

  Specific examples of the ingredients derived from plant-based materials used as additives include Dunaliella genus Dunaliella extract, Chlorococcus chlorococcus extract, Anemone genus mulberry extract, Volbox genus genus extract, Volbox genus Volbox extract, Palmera extract, Jupiter extract, Aomydra spp. Extract, Papilio spp. Extract, cassava extract, cicada extract, colecaete extract, cicada extract, duckweed extract, crayfish Green extract such as Loa extract, Kunshomo extract, Sumiremo violet extract, Hosimidro extract, Fuchinashimidro extract Iso Grape Extract, Isogawara Isogawara Extract, Kurogashira Gunsen Kurogashira Extract, Kashirazaki Kashirazaki Extract, Muchimo Muchimo Extract, Muchimo Hiramchimo Extract, Muchimo Keribergusa Extract, Amygusa Sakibiro Amiji Extract, Common Sasa Common Gusa Extract, Jigamigusa Genus Jigmyusa extract, Nami-makura genus Hirami-makura extract, Someraceae genus Someraceae extract, Navaimo genus Navarimo extract, Chasomen moth Chasomen extract, Nagamatsu sp. Nagamatsu sp. Rabbit extract, Rhizoma spp. Weeping Manori Extract, Weeping Crab Extract, Fritillaria Fistula Extract, Cultivation Crane Extract, Frog Brown algae extract such as genus Chlome extract, Chrysanthemum genus Chrysanthemum extract, Nerecomb genus Nerecomb extract, Spirella spp. Extract, Amanori Tasa Extract, Amanori Firitasa Extract, Amanori Benitasa Extract, Rhodocorton Mirnoveni Extract, Kona Hada Hyakona Hada Extract, Kona Hada Yokore Kona Hada Extract, Kona Hada Ao Naha Hada Extract, Rhizobium Genus Thrips Gassilori extract, pine genus pine extract, Nisefusanori genus Fusanoori extract, Sodegarami genus Sodegarami extract, Hirohata Tadaki genus Hirohata Mitaki extract, Amanita Nambugusa extract, Tengususa spp. Pseudomonas spp. Crabnote extract, Coral spider coral extract, Centipede spruce cadaver extract, Centipede spruce extract, Centacum spp. Denori genus centipede extract, centipede genus vine extract, centipede genus fudarak extract, genus genus marbahudarak extract, cypress genus cypress extract, arabe genus madder extract, quince genus chabo kintoki extract, kinto genus kintoki extract Pine extract, Kintoki-Hitomatsu extract, Kintoki-Bushiki-toki-toki extract, Kintoki-tsunomu-kade extract, Kintoki-toga-kinki-toki extract, Kintoki-suji-kadeki extract, Kakera-to-spotted oakkin-toki extract, Nagaobane-genus Nagaobane extract, Kalekigusa-kalekigusa extract, Kinuhada Genus Kinu Hada extract, Tsukasanoori Enashikarimenia extract, Tsukasanoori Otsukasanori extract, Tsukasanoori Hanagatakarimenia extract, Ho Genus honoo extract, genus genus genus genus extract, genus genus genus Usugineu extract, genus genus genus genus urchinum extract, venus nago genus venus nago extract, skunk genus suskake beni extract, okaramusa genus genus extract, isomocca genus isomokka extract, pheasant genus pheasant extract Isodantsu Isodantsu Extract, Atsubanori Atsubanori Extract, Ogonori Mizoogonori Extract, Ogonori Beniogonori Extract, Ogonori Ukureshinori Extract, Ogonori Murasakibibanori Extract, Ogonori Sinkaibanori Extract, Ogonori Extract , Ogonori genus Katagogonori extract, Ogonori genus Ryukyu Ogonori extract, Ogonori genus Ogonori extract, Ogonori genus Ituginu extract, Ogonori genus Yumi Ganoderma extract, Ogonori genus Kubileogonori extract, Ronus spruce genus extract, Ronus spp. Scorpion genus extract, Rhizoma genus extract, Sedum genus extract, Scots squirrel extract, Scutella genus extract, Scutella genus extract, Scutella genus extract, Scutella genus extract, Fukutsunagi extract Hanaedae extract, Hirata goat Hirata goat extract, Dulse scorpion extract, Dulse anadalus extract, Webagus webag Extract , Konohanori extract, Suzushironori extract, Usbeni spp.usbeni extract, Hasujiginu spp. Hyus vanori genus Suusus banori extract, Hyus banori genus Hyus banori extract, Usubanorimodoki genus Usubanorimodoki extract, Ayanishiki genus Ayanishiki extract, Goatium Aeginu Extract, Dadia Enasidadia Extract, Shimadadia Isohagi Extract, Shimadadia Shimadadia Extract, Dajimodaki Dajimomodoki Extract, Makuri Makuri Extract, Hanegusa Hanagusa Extract, Hanegusa Kehanegusa Extract, Kozanemo Kozaemone Kozaemone Cozanemo sp. Red algae such as Isobasho genus Isobasho extract, Ideukogome genus Yukogome extract, Ochimodoku genus Okichimozuku extract, Chisujinori genus Chisujinori extract Extracts, Shajikumo Extract, Shirahamamo Extract, Hoshitsurimo Hoshitsurimo Extract, Rikunotumnusu Extract, Flasmocha spp. It is done.

  Specific examples of ingredients derived from animal materials used as active ingredients or additives include chicken crown extract, cow, pig or human placenta extract, pig or cow stomach, duodenum, intestine, spleen extract or degradation products thereof. , Bovine or porcine brain tissue extract, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolysate, elastin, elastin hydrolysate, water-soluble elastin derivative, keratin and its degradation product or derivatives thereof, silk Proteins and degradation products thereof or derivatives thereof, porcine or bovine blood cell protein degradation products (globin peptides), cattle or pig hemoglobin degradation products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and degradation thereof Products or derivatives thereof, skim milk powder and decomposition products thereof or derivatives thereof, lactoferrin or decomposition products thereof, chicken egg formation , Fish hydrolyzate, nucleic acid-related substance (ribonucleic acid, deoxyribonucleic acid), and the like.

  Specific examples of components derived from microbial materials used as active ingredients or additives include yeast metabolites, yeast extract extracts, bacterial metabolites, bacterial extract extracts, metabolites such as molds or mushrooms, actinomycetes metabolites , Extracts such as mold or mushroom, actinomycetes extract, natto metabolite, natto extract, fermented rice extract, fermented rice bran (red rice bran, birch) fermented extract, euglena extract or its degradation products or their water-soluble derivatives, raw milk Or the lactic acid fermented product of skim milk powder, a trehalose, its derivative (s), etc. are mentioned.

  In addition, as a plant, animal, or microbial material, any site, cell, tissue, organ, metabolite, etc. derived from a transgenic body or a cell fusion can be used. Furthermore, it is obtained by culturing cells of any site, cell, tissue, organ, etc., for example, cultured cells derived from each tissue (cultures derived from animals such as fibroblasts, Langerhans cells, macrophages, epidermal cells, hepatocytes, etc.) Cell etc.), undifferentiated cell group, cell group in the middle of differentiation, and their metabolites can also be used.

  Specific examples of components of natural raw materials used as active ingredients or additives include seawater such as deep seawater, for example, sea salt, seawater dried product, Dead Sea, Atlantic Ocean or Pacific Ocean. Sodium, magnesium chloride, potassium chloride, etc.), sea mud or mud (fungo), for example, sea mud or mud in various places such as Italian fungo, German fungo, Eifelfango, Freiburg fungo (containing components: silicon dioxide, titanium dioxide, Aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water) , Saintoku stone, natural smectite, bentonite, hectorite, etc. It is.

  Extracts derived from plant-based raw materials, animal-based raw materials, microbial-based raw materials, and other natural product raw materials used as active ingredients or additives are processed in a conventional manner according to the product type and form to be added (for example, pulverized) , Milling, washing, extraction, degradation, fermentation or metabolic conversion by microorganisms, fractionation, purification, pressing, filtration, drying, powdering, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. It is only necessary to select and use any of various materials.

  The solvent used for extraction may be selected in consideration of the intended purpose and type of the product to be provided or the processing to be performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isopropanol are used. Lower alcohol such as butanol or hydrous lower alcohol, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1, 3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, 1,2-hexanediol, 1,5-hexanediol, 1,6-hexanediol, pentylene glycol, hexylene glycol, Polyhydric alcohols such as glycerin and polyethylene glycol (molecular weight 100 to 100,000) or hydrous polyhydric alcohols, alcohols T, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, carbon tetrachloride, phenol, toluene, and other organic solvents, and acids prepared with appropriate normality (hydrochloric acid, sulfuric acid, It is desirable to use one or a mixture of two or more selected from nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.). However, when it is not preferable to contain a solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it can be used alone or in any mixture with water. What was extracted may be sufficient.

  Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. The temperature of the solvent can be arbitrarily set in the range of −4 ° C. to 100 ° C., but is preferably around 10 to 40 ° C. from the viewpoint of the stability of the components contained in the raw material. Further, the weight ratio of the solvent to the raw material can be arbitrarily set within the range of, for example, raw material: solvent 4: 1 to 1: 100, and a weight ratio of 1: 1 to 1:10 is particularly preferable.

  Decomposition mainly includes acid decomposition, alkali decomposition, enzyme decomposition, and high-temperature and high-pressure decomposition. In the decomposition with an acid, for example, it is preferable to use an inorganic acid or an organic acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, oxalic acid, hydrogen bromide, perchloric acid, and periodic acid. In the decomposition by alkali, for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, barium hydroxide, sodium carbonate, ammonium carbonate, calcium carbonate, magnesium hydroxide, sodium silicate, etc. are preferably used. In the decomposition with acid or alkali, the concentration, reaction time, reaction temperature, and the like can be arbitrarily set for the target raw material. In the enzymatic degradation, it is preferable to use an enzyme having a function of degrading proteins, polysaccharides, lipids or complexes thereof having an important function particularly with respect to cell structure, tissue structure, etc., for example, aminopeptidase, dipeptidase, dipeptide Peptidyl peptidase, tripeptidyl peptidase, carboxypeptidase, serine protease, trypsin, chymotrypsin, cysteine protease, thiol protease, papain, aspartate endopeptidase, metalloendopeptidase, promeline, thermolysin, pronase, pepsin, rennin, Proteolytic enzymes (proteases) such as pancreatin, chymopapain, ficin, collagenase, elastase, amylase, takaamylase, cellulase, hemicellular Polysaccharide-degrading enzymes such as zectin, pectinase, polygalacturonase, dextranase, and pralanase, hen egg white lysozyme, human lysozyme, papaya lysozyme, cabra lysozyme, barley lysozyme, zymolyce, lysozyme chloride, glucanase, gluco Examples include cell wall lytic enzymes such as uronidase, chitinase, and kilosanase. In the case of using an enzyme, the concentration, reaction time, reaction temperature, pH of the solution, and the like can be arbitrarily set, but it is particularly preferable to set the optimum value for the enzyme used.

Fermentation or metabolic conversion by microorganisms can be carried out by inoculating and growing at least one or more microorganisms on a raw material used as a substrate. Inoculation of microorganisms to the substrate can be done by adding microorganisms directly into the substrate, or by adsorbing them on a carrier such as alginic acid, polyvinyl, gelatin, etc., for example, in the form of fine beads composed of microorganisms and carrier. Further, it can be used by being fixed to the tube wall of the bioreactor. Fermentation or metabolic conversion by microorganisms is not particularly defined as a microorganism to be used, but can generally be defined as microorganisms other than pathogenic microorganisms that exhibit significant toxicity to living bodies. Examples of microorganisms to be used include microorganisms classified into yeasts: Aciculoconidium, Actonia, Aessosporon, Ambrosiozyma, Amphierna, Anthomyces, Apiotrichum, Arthroascus, Arxula, Ascotrichosporon, Ashbia, Ashbya Genus, Asporomyces, Atelosaccharomyces, Azymocandida, Azymohansenula, Azymomyces, Azymoprocandida, Babjevia, Ballistosporomyces, Basidiotrichosporon, Bensingtonia, Blastobotrysbota, Blastodlastrzo Brettanomyces (Brettanomyces bruxellensis, Brettanomyces anomalus, etc.), Bullera, Bulleromyces, Candida (Candida albicans, Candida amylolenta, Candida anomala, Candida boidinii, Candida entomaea, Candida etchellsment, Candida etchellsii, Candida etchellsment Candida intermedia, Candida krusei, Candida lactosa, Candida lipolytica, Candida mogii, Candida parapsilosis, Candida sake, Candida tropicalis, Candida versatilis, Candida vulgaris, etc., Castellania, Chlamydozyma, Chromotorula, Citeromyces, Cladosporium, Clavispora, Crebrothecium, delbaryo, genus halotolerans, Debaryomyces hansenii, etc.), Debaryozyma, Dekkera, Dekkeromyces, Dematium, Dipodascus, Eeniella, Enantiothamnus, Endoblastoderma, Endoblastomyces, Endomyces, Endomycopsis, Endyllium, Etelexium, Entelex Genus, Eutorula, Eutorulopsis, Fabospora, Fellomyces, Fermentotrichon, Filobasidium, Galactomyces, Geotrichoides, Geotrichum, Guilliermondella, Hanseniaspora, Hansenulaan, Hansenulaan, Hansenulaan, Hansenula Hansenula wickerhamii), Hypomyces, Issatchenkia, Kloeckera (Kloeckera brevis, Klo) eckera fluorescens, Kloeckera japonica, etc.), Kloeckeraspora, Kluyveromyces (Kluyveromyces bulgaricus, Kluyveromyces marxianus, Kluyveromyces thermotolerans, Genus Kockovaella, Kurtzmanomyces, Leucosporidium, Leucosporidium, Leucosporidium Monospora, Monosporella, Mrakia, Myceloblastanon, Mycocandida, Mycoderma, Mycotorula, Mycokluyveria, Mycotoruloides, Myxozyma, Nadsonia, Nectaromyces, Nematospora, Otosporomyces, Ogataea, Ogataea , Oosporidium genus, Pachysolen genus, Parasaccharomyces genus, Paratorulopsis genus, Parendomyces genus, Petasosospora genus, Pichia genus (genus Pichia amylophila, Pichia farinosa, Pichia guilliermondii, Pichia membranifaciens, Pichia mogirum, genus Proticcpo Proteomyces, Pseudohansenula, Pseudomonilia, Pseudomycoderma, Pseudosaccharomyces , Pseudozyma spp, Rhodomyces genus, Rhodosporidium genus, Rhodotorula genus, Saccharomyces genus (Saccharomyces aceti, Saccharomyces cerasi, Saccharomyces cerevisiae, Saccharomyces exiguus, Saccharomyces unisporus, Saccharomyces fibuligera etc.), Saccharomycodes genus, Saccharomycopsis spp, Saturnispora genus, Schizoblastosporion spp, Schizosaccharomyces spp , Schwanniomyces genus, Selenotila genus, Selenozyma genus, Smithiozyma genus, Sporidiobolus sp Genus, Vanrija, Waltomyces, Willia, Willopsis, Wingea, Xanthophyllomyces, Yamadazyma, Zendera, Zygofabospora, Zygopichia, Zygohansenula, Zygorenospora, Zygosaccharomyces, Zygosaccharomyces, etc. . Microorganisms classified as bacteria include Acetobacter genus (Acetobacter aceti, etc.), Achromobacter genus, Acidianus genus, Acidobacterium genus, Acidithiobacillus genus, Acrocarpospora genus, Actinoalloteichus genus, Actinocorallia genus, Actinokineospora genus, Actinomadspura genus, Actinomadspura Actinosynnema genus, Aerococcus genus, Aeromicrobium genus, Agrobacterium genus, Agromyces genus, Ahrensia genus, Alcaligenes genus, Alicyclobacillus genus, Alloiococcus spp. , Aureobacterium genus, Azotobacter genus, Bacillus genus (Bacillus brevis, Bacillus subtilis etc.), Bacteroides genus, Beneckea genus, Bifidobacterium genus (Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis etc.), Brachybacterium genus, Brevicillus, Brevundimonas, Burkholderia, Carnobacterium, Catellat genus ospora, Cellulomonas, Chainia, Chromobacterium, Chryseobacterium, Citrobacter, Clavibacter, Corynebacterium, Couchioplanes, Cryptosporangium, Curtobacterium, Dactylosporangium, Deinococcus, Delftia, Dermatia, Dermatia , Elytrosporangium, Enterobacter, Erwinia, Escherichia, Eubacterium, Excellospora, Exiguobacterium, Faenia, Flammeovirga, Flavobacterium, Flexibacter, Geodermatophilus, Globicatella, Gluconacetobaceto, Gluconacetobacter Genus, Gordonia, Halobacterium, Halococcus, Herbidospora, Hydrogenophilus, Hyphomicrobium, Hyphomonas, Intrasporangium, Janibacter, Jonesia, Kibdelosporangium, Kineopocusato, Kitasposatos, Kitasposatos, Kitasposatos Klebsiella, Kocuria, Kurthia, Lactobacillus (Lactobacillus rimae, Lactobacillus dive rgens, Lactobacillus carnis, Lactobacillus piscicola, Lactobacillus acidophilus, Lactobacillus amylophilus, Lactobacillus animalis, Lactobacillus brevis, Lactobacillus casei, Lactobacillus curvatus, Lactobacillus bulgaricus, Lactobacillus delbrueckii, Lactobacillus fermentum, Lactobacillus fructivorans, Lactobacillus fructosus, Lactobacillus helveticus, Lactobacillus hilgardii, Lactobacillus homohiochii, Lactobacillus kefiri, Lactobacillus malefermentans, Lactobacillus murinus, Lactobacillus paracasei, Lactobacillus paracasei subsp. tolerans, Lactobacillus parakefiri, Lactobacillus pentosus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus sakei, Lactobacillus confusus, Lactobacillus viridescens, Lactobacillus johnsonii, Lactobacillus viscosus, Lactobacillus bunchneri , Lactobacillus fermentatae, Lactobacillus acidophil-aerogenes, Lactobacillus leichmannii, Lactobacillus gasseri, Lactobacillus bifidus, Lactobaci llus jugurt, Lactobacillus caucasicus, Lactobacillus arabinosus, Lactobacillus kunkeei, Lactobacillus nagelii, Lactobacillus fornicalis, Lactobacillus pentoaceticus, Lactobacillus xylosus, Lactobacillus minutus, etc.), Leuconostoc genus (Leuconostoc lactis, Leuconostoc dextranicum, Leuconostoc mesenteroides, Leuconostoc oenos, Leuconostoc paramesenteroides, Leuconostoc cremoris, Leuconostoc citrovorum etc.), Listonella genus, Lucibacterium genus, Luteococcus genus, Magnetospirillum genus, Marinilabilia genus, Marinospirillum spp. Genus, Nocardioides, Nonmuraea, Nonomuria, Oceanospirillum, Ochrobactrum, Oerskovia, Oligella, Paenibacillus, Pediococcus ui, etc.), Pedobacter, Peptococcus, Peptostreptococcus, Pilimelia, Pimelobacter, Planobispora, Planococcus, Planomonospora, Prevotella, Propionibacterium, Proteus, Protomonas, Pseudomonas, Genus, Rathayibacter, Rhizobium, Rhizomonas, Rhodobacter, Rhodococcus, Rhodopseudomonas, Rhodospirillum, Rothia, Rubrobacter, Ruegeria, Saccharomonospora, Siracrothinas, Sporolactobacillus spp., Stenotrophomonas spp., Streptoalloteichus spp., Streptococcus spp. (Streptococcus durans, Streptococcus faecalis, Streptococcus faecium, Streptococcus bovis, Streptococcus equinus, Streptococcus mutans, Streptococcus salivarius, Streptococcus thermophilus, Streptococcus agalactiae, Streptococcus mitis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus lactis , Streptococcus dysgalactiae, Streptococcus sanguis, Streptococcus acidominimus, Streptococcus avium, Streptococcus uberis, Streptococcus cremoris, Streptococcus diacetilactis, etc. Genus, Thiobacillus genus, Thiomonas genus, Thiosphaera genus, Weissella genus, Xanthobacter genus, Xanthomonas genus, Zymomonas genus and the like. Microorganisms classified as ascomycetes, basidiomycetes or incomplete fungi other than yeast include Allomyces, Amoebidium, Amorphotheca, Arthroderma, Ascoidea, Ascobolus, Ascodesmis, Aspergillus, Aureobasidium, Botryosphaeria , Botryotinia, Brachybasidium, Byssochlamys, Capnodium, Ceratocystis, Ceratomyces, Chaetomium, Chrysella, Chrysocelia, Chytridium, Claviceps, Cochliobolus, Coemansia, Genus Genus, Cyttaria, Dasyspora, Derchslera, Dirchmyces, Dichomyces, Dothidea, Endogone, Entomophthora, Emericella, Eupenicillium, Eurotium, Exobasidium, Gibberella, Glomus, Graphiola, Gymnoascus, Harpella Helicomyces, Hellvella, Hemicarpenteles, Hyphochytrium, Hypocrea, Laboulbenia, Labyrinthula, Leptosphaeria, Leptosphaerulina, Lophodermium, Melanotaenium , Microascus, Microstroma, Medeolaria, Melampsora, Melampsporella, Morchella, Monascus, Monilinia, Monoblephalis, Mycospharella, Nannizzia, Nectria, Neolecta, Neurospora, Nodulosphaeria, Olizadium, Genus, Penicillium, Perenospora, Pestalotiopsis, Phomopsis, Phragmi
diella genus, Pneumocystis genus, Preussia genus, Pleospora genus, Puccinia genus, Pythium genus, Ravenelia genus, Rickia genus, Rhinocladiella genus, Rhizidiomyces genus, Rhizoctonia spp. Sordaria genus, Sporidiobolus genus, Stibella genus, Stigmatomyces genus, Sydowiella genus, Talaromayces genus, Taphrina genus, Thraustochytrium genus, Tolyposporium genus, Trichoglossum genus, Trichoma genus, Ustilago genus, Verticillium genus, Xylaria genus and the like.

  In fermentation or metabolic conversion by microorganisms, in addition to various raw materials such as plant-based materials, animal-based materials, and other natural product-based materials, the growth and metabolism of microorganisms are regulated or activated, and special biosynthesis or degradation pathways are induced. In order to achieve this, various compounds can be added to the raw material. For example, as a carbon source, a sugar or ethane such as glucose, fructose, galactose, sucrose, maltose, mannose, lactose, glycerol, starch, etc. , Hydrocarbons such as methane, propane, butane, formic acid, acetic acid, propionic acid, lauric acid, palmitic acid, fatty acids such as oleic acid, linoleic acid, linolenic acid, etc., nitrogen sources such as ammonium sulfate, ammonium hydrochloride, ammonium phosphate, etc. Ammonium salt, urea, uric acid, amino acids, etc. Vitamins and compounds that contain potassium, calcium, magnesium, sodium, sulfur, phosphorus, chlorine, etc., as well as iron, copper, zinc, cobalt, nickel, boron, manganese, molybdenum, tin, selenium, silicon It is possible to further add compounds contained in the composition such as arsenic, vanadium, chromium and fluorine. In addition, the optimum temperature, oxygen supply amount, pH, pressure, etc. that affect the growth and metabolic activity of various microorganisms can be arbitrarily set according to the characteristics inherent to various microorganisms. Can be arbitrarily set in the range of 10 to 50 ° C., and the pH can be arbitrarily set in the range of 1 to 14.

  In fractionation or purification, generally known techniques can be used as appropriate. In addition to solvent extraction, for example, liquid chromatography (ion exchange chromatography, ion exclusion chromatography, affinity chromatography, gel filtration chromatography, size exclusion chromatography, etc.). Chromatography, hydrophilic adsorption chromatography, hydrophobic adsorption chromatography, ligand exchange chromatography, etc.), dialysis with semipermeable membrane, crystallization and recrystallization of components, filter paper, membrane filter, ultra filter, Examples thereof include density gradient separation methods such as filtration using activated carbon and filter aid, centrifugal separation, and fractional precipitation methods, density gradient sedimentation equilibrium methods, and the like.

In the present invention, as other compounds used as additives, specifically, silicic anhydride, magnesium silicate, talc, kaolin, bentonite, hectorite, natural or synthetic smectite, stevensite, mica, mica titanium, bismuth oxychloride , Zirconium oxide, Magnesium oxide, Zinc oxide, Titanium oxide, Calcium carbonate, Magnesium carbonate, Yellow iron oxide, Bengala, Black iron oxide, Gunjo, Chromium oxide, Chromium hydroxide, Carbon black, Calamine and other inorganic pigments, Peroxide Hydrogen water, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium peroxide tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate, silica Acid Inorganic reducing agents such as lithium hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide , Redox agents such as thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate), 5-aminoorthocresol, 2-amino-4 -Nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene hydrochloride -2,5-diamine, nitroparaphenylenediamine hydrochloride , Paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxy Naphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium picrate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, meta Phenylenediamine, 5-aminoorthocresol sulfate , 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, sulfuric acid Nitroparaphenylenediamine, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine, catechol, diphenylamine, α- Natural dyes such as naphthol, hydroquinone, phloroglucin, sodium 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonate, hematein, musk, civet, castrium, ambergris Physical Flavor, Anise Essential Oil, Angelica Essential Oil, Ylang Ylang Essential Oil, Iris Essential Oil, Fennel Essential Oil, Orange Essential Oil, Kananga Essential Oil, Caraway Essential Oil, Cardamom Essential Oil, Guayak Wood Essential Oil, Cumin Essential Oil, Black Letter Essential Oil, Cinnamon Essential Oil, Cinnamon Essential Oil, Geranium Essential Oil, Copaiba balsam essential oil, coriander essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil, dairy perfume essential oil, tuberose essential oil, clove essential oil, orange flower essential oil, winter green Essential Oil, Truval Sam Essential Oil, Baturi Essential Oil, Rose Essential Oil, Palmarosa Essential Oil, Persimmon Essential Oil, Hiba Essential Oil, Sandalwood Essential Oil, Petit Glen Essential Oil, Bay Essential Oil, Vetiva Essential Oil, Bergamot Essential Oil, Peruvian Balsam Essential Oil, Boadrose Essential Oil, Haruka Essential Oil, Mandarin Essential , Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaroe essential oil, Lemongrass essential oil, Lemon essential oil, Rosemary essential oil, Japanese mint mint essential oil and other plant flavors, other synthetic flavors, 5-amino-o-cresol, o -Aminophenol, m-aminophenol, p-aminophenol, 2,6-diaminopyridine, 5- (2-hydroxylethylamino) -2-methylphenol, N, N-bis (β-hydroxyl) -p-phenylene Diamine / sulfate, N, N-bis (2-hydroxyethyl) -p-phenylenediamine, p-nitro-o-phenylenediamine, p-phenylenediamine, m-phenylenediamine, N-phenyl-p-phenylenediamine, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene / sodium sulfate, toluene-2,5-diamine, 2- (2'-hydroxyethylamino) -5-aminotoluene, N, N-bis ( β-hydroxyl) -p-fu Nylenediamine, N, N-bis (2-hydroxyethyl) -p-phenylenediamine sulfate, 5-amino-o-cresol sulfate, p-aminophenol sulfate, o-chloro-p-phenylenediamine Sulfate, 2- (2'-hydroxyethylamino) -5-aminotoluene, sulfate, 4,4'-diaminodiphenylamine, sulfate, p-methylaminophenol, sulfate, p-phenylenediamine, sulfate, m-phenylenediamine sulfate, toluene-2,5-diamine sulfate, 2,4-diaminophenoxyethanol hydrochloride, toluene-2,5-diamine hydrochloride, m-phenylenediamine hydrochloride, 2, 4-diaminophenol hydrochloride, 3,3'-iminodiphenol, p-phenylenediamine hydrochloride, N-phenyl-p-phenylenediamine hydrochloride, N-phenyl-p-phenylenediamine acetate 1 , 5-dihydroxynaphthalene, Ruen-3,4-diamine, p-methylaminophenol, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, o-aminophenol sulfate, 2,4 -Diaminophenol sulfate, m-aminophenol sulfate, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, nitro-p-phenylenediamine Hydrochloride, 1,4-diaminoanthraquinone, nitro-p-phenylenediamine, picramic acid, sodium picramate, 2-amino-5-nitrophenol / sulfate, resorcinol, nitro-p-phenylenediamine / sulfate, p- Nitro-o-phenylenediamine sulfate, p-nitro-m-phenylenediamine sulfate, red No. 2, red No. 3, red No. 102, red No. 104 (1), red No. 105 (1), Red No. 106, Red No. 201, Color 227, Red 230 (1), Red 230 (2), Red 231, Red 232, Red 401, Red 502, Red 503, Red 504, Red 506, Yellow 4 No. 5, Yellow No. 5, Yellow No. 202 (1), Yellow No. 202 (2), Yellow No. 203, Yellow No. 402, Yellow No. 403 (1), Yellow No. 406, Yellow No. 407, Orange No. 205, Orange No. 207, Orange No. 402, Green No. 3, Green No. 204, Green No. 205, Green No. 401, Green No. 402, Brown No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 202, Blue 203 No., Blue No. 205, Black No. 401, Red Cabbage Dye, Red Rice Dye, Akane Dye, Anato Dye, Ikumi Dye, Turmeric Dye, Enju Dye, Krill Dye, Amber Dye, Caramel, Gold, Silver, Gardenia Dye, Corn Dye , Onion pigment, onion Dyes, spirulina dyes, buckwheat whole plant dyes, cherry dyes, laver dyes, hibiscus dyes, grape juice dyes, marigold dyes, purple potato dyes, purple yam dyes, lacquer dyes, rutin dyes and coloring agents, avocado oil, Almond oil, fennel oil, sesame oil, olive oil, orange oil, orange raffer oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber nut oil, safflower oil, shea fat, liquid shea fat, large Bean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, coconut oil, beef tallow, lard Oils such as hydrogenated products (hardened oil, etc.), beeswax, carnauba wax, whale wax, lanolin, liquid lano Phosphorus, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax, waxes such as squalene, squalane, pristane, mineral oils such as liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcristane wax, lauric acid, myristin Acids, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, natural fatty acids such as 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, capron Acids, fatty acids such as 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid, isopentanoic acid and the like, synthetic fatty acids, ethanol, isopyropanol, lauryl alcohol, cetanol, Natural alcohols such as teal alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, alcohols such as synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, 2-octyldodecanol, isopropyl myristate, isopropyl palmitate, Butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyl decyl dimethyloctanoate, diisobutyl adipate, 2-hexyldecyl adipate, diheptyl undecyl adipate, monoisostearate Acid N-alkyl glycol, isocetyl isostearate, trimethylolpropane triisostearate, diethylhexyl Ethylene glycol sanate, neopentyl glycol diethylhexanoate, cetyl 2-ethylhexanoate, trimethylolpropane triethylhexanoate, pentaerythritol tetraethylhexanoate, cetyl octanoate, octyldodecyl gum, cetyl lactate, myristyl lactate, diethyl phthalate, Esters such as dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate , Metal soaps such as zinc laurate and zinc undecylenate, anionic surfactants (alkyl carboxylates, alkyls Honates, alkyl sulfates, alkyl phosphates), alkyl sulfates (sodium lauryl sulfate, potassium lauryl sulfate, triethanolamine lauryl sulfate, ammonium lauryl sulfate, sodium cetyl sulfate, sodium stearyl sulfate, etc.), secondary Alcohol sulfate ester salt, alkyl ether sulfate ester salt (for example, polyoxyethylene lauryl sulfate triethanolamine, sodium polyoxyethylene lauryl sulfate), alkyl and alkyl allyl ether sulfate ester salt (N-acylmethylalanine salt, N-acyl) Glutamate, N-acylmethyl taurate, N-acyl isethionate, N-acyl glycine, alkyl phosphate, alkyl ether carboxylate, alkyl sulfonate, alkyl Killsulfosuccinate, sodium polyoxyethylene lauryl ether sulfate, polyoxyethylene lauryl ether sulfate triethanolamine, polyoxyethylene lauryl ether ammonium sulfate, polyoxyethylene alkyl ether sodium sulfate, polyoxyethylene alkyl ether sulfate triethanolamine, polyoxy Ethylene alkyl ether sulfate diethanolamine, polyoxyethylene alkyl ether ammonium sulfate, etc.), higher fatty acid alkylolamide sulfate ester salt, higher fatty acid ester sulfate ester salt (hardened coconut oil fatty acid sodium glyceryl sulfate, etc.), polyoxyethylene alkyl ether carboxylic acid, poly Oxyethylene alkyl allyl ether carboxylates, sulfated oils such as sulfated castor oil, Dialkyl or alkenyl phosphate salts, polyoxyethylene mono or dialkyl or and alkenyl
Acid ester salt (sodium monolauryl phosphate, sodium isostearyl phosphate, arginine 2-hexyldecyl phosphate, potassium 2-heptylundecyl phosphate, polyoxyethylene (4-10) sodium lauryl ether phosphate, sodium monocetyl phosphate Arginine monomyristyl phosphate, sodium monooleyl phosphate, polyoxyethylene (2-10) potassium lauryl ether, sodium dioctyl phosphate, etc.), polyoxyethylene alkyl ether phosphate ester salt (polyoxyethylene lauryl ether) Phosphoric acid, polyoxyethylene oleyl ether phosphoric acid, polyoxyethylene cetyl ether phosphoric acid, polyoxyethylene stearyl ether phosphoric acid, polyoxyethylene alkyl ether phosphoric acid, poly Xyethylene alkylphenyl ether phosphate, etc.), sulfonates of higher fatty acid amides or sulfonates of higher fatty acid esters (α-olefin sulfonate, N-myristoyl-N-methyltaurine sodium, coconut oil fatty acid methyltaurine sodium, Sodium lauroylmethyl taurate, etc.), alkylbenzene sulfonate (dodecylbenzenesulfonic acid, monoethanolamine dodecylbenzenesulfonate, diethanolamine dodecylbenzenesulfonate, triethanolamine dodecylbenzenesulfonate, sodium dodecylbenzenesulfonate, etc.), sulfosuccinate (Sodium diethylhexyl sulfosuccinate, sodium sulfosuccinate, disodium lauryl sulfosuccinate, polyoxyethylene sulfosuccinate Disodium acid, disodium lauryl polyoxyethylene sulfosuccinate, disodium polyoxyethylene lauroyl ethanolamide ester sulfosuccinate, disodium undecylenoylamide ethylsulfosuccinate, monolauroyl monoethanolamide sodium polyoxyethylene sulfosuccinate, lauryl polypropylene glycol Sodium sulfosuccinate, etc.), N-acyl sarcosine salts (such as sodium lauroyl sarcosine, palmitoyl sarcosine sodium), condensates of higher fatty acids and amino acids (N-acyl glutamate, sodium N-stearoyl glutamate, potassium N-palmitoyl glutamate, N- Lauroyl-L-glutamate sodium, N-stearoyl-L-glutamate disodium, -Sodium myristoyl-L-glutamate, sodium myristoyl methyl taurate, sodium palmitoyl methyl taurine, sodium stearoyl methyl taurine, N-palmitoyl-β-alanine arginine, N-palmitoyl aspartate ditriethanolamine, etc.), oleate, suaraic acid Anionic surfactants such as fatty acid soaps such as salts, laurates and palmitates (examples of anionic surfactants include alkali metal salts such as sodium salts and potassium salts, monoethanolamine salts and diethanolamine salts) , Quaternary ammonium salts (alkyltrimethylammonium chloride, cetyl chloride, etc.), organic ammonium salts such as triethanolamine salt, L-lysine salt, L-arginine salt and the like, and ammonium salts. Ammonium, cetyl ammonium bromide, lauryl ammonium chloride, lauryl ammonium bromide, stearyl ammonium chloride, stearyl ammonium bromide, cetyl dimethyl ammonium chloride, cetyl dimethyl ammonium bromide, lauryl dimethyl ammonium chloride, stearyl dimethyl ammonium chloride, lauryl trimethyl ammonium chloride , Lauryl trimethyl ammonium bromide, stearyl dimethyl cetyl ditallow dimethyl ammonium chloride, dicetyl ammonium chloride, dicetyl ammonium bromide, dilauryl ammonium chloride, dilauryl ammonium bromide, distearyl ammonium chloride, distearyl ammonium bromide, chloride Dicetylmethylammonium, dicetylmethylammonium bromide, dilaurylmethylan chloride Nium, dilaurylmethylammonium bromide, distearylmethylammonium chloride, distearylmethylammonium bromide, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, lauryltrimethylammonium bromide, Dialkyldimethylammonium chloride, dicetyldimethylammonium chloride, distearyldimethylammonium chloride, dicocoyldimethylammonium chloride, myristyldimethylbenzylammonium chloride, stearyldimethylbenzylammonium chloride, ethyl lanolin sulfate fatty acid aminopropylethyldimethylammonium chloride, cetyltrimethylammonium chloride, Stearyltrimethylammonium chloride, Behenyltrimethylammonium chloride, behenyldimethylhydroxyethylammonium chloride, stearyldimethylbenzylammonium chloride, distearyldimethylammonium chloride, distearoylethylhydroxyethylmonium metasulfate, dicocoylethylhydroxyethylmonium metasulfate, dipalmitoylethylhydroxyethylmonium metasulfate , And cetyltriethylammonium methylsulfate, alkyltrimethylammonium chloride, alkyldimethylbenzylammonium chloride, dialkyldimethylammonium chloride, alkyltrimethylammonium bromide, alkylpentaethoxyammonium chloride, ditallowdimethylammonium chloride, ditallowdimethylammonium methylsulfate , Ammonium ditallow dipropyl phosphate, ditallow dimethyl ammonium nitrate, di (coconut alkyl) dimethyl ammonium chloride, di (coconut alkyl) dimethyl ammonium bromide, coconut ammonium chloride, stearamide propyl chloride PG-dimonium phosphate, steer Luamidopropylethyldimonium esosulphate, stearamidepropyldimethyl (myristyl acetate) ammonium chloride, stearamidepropyldimethylcetearylammonium tosylate, stearamidepropyldimethylammonium chloride, stearamidepropyldimethylammonium lactate, ethyl sulfate Lanolin fatty acid aminopropylethyldimethylammonium, cationized cellulose, acyl diethylaminoethyl acetate , Acyldimethylaminopropylamide, polyoxyethylene fatty acid amide, myristyldimethylamine oxide, N-lauryldimethylaminoacetic acid betaine, N-myristyldimethylaminoacetic acid betaine, N-stearyldimethylaminoacetic acid betaine, etc.), bis fatty acid ester salt ( Hydroxypropyl-bis-lauric acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-myristic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-palmitic acid amidopropyl-N, N- Dimethylammonium chloride, hydroxypropyl-bis-stearic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-behenic acid Midopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-oleic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-isostearic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis -Palm fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-tallow fatty acid amidopropyl-N, N-dimethylammonium chloride, Hydroxypropyl-bis-lauric acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-myristic acid amidoethyl-N N-diethylammonium chloride, hydroxypropyl-bis-palmitic acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-stearic acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-behenic acid amidoethyl- N, N-diethylammonium chloride, hydroxypropyl-bis-oleic acid amidoethyl ammonium chloride, hydroxypropyl-bis-isostearic acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidoethyl-N, N- Diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidoethyl-N, N-diethylammonium chloride, hydro Cypropyl-bis-tallow fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-lauric acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-myristic amidopropyl-N, N-diethylammonium Chloride, hydroxypropyl-bis-palmitate amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-amidopropyl stearate-N, N-diethylammonium chloride, hydroxypropyl-bis-behenate amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-oleic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis- Sostearic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidopropyl-N, N-diethylammonium chloride, Hydroxypropyl-bis-tallow fatty acid amidopropyl-N, N-diethylammonium chloride, etc.), stearamidepropyl PG-dimonium chloride phosphate, behenamidopropyl PG dimonium chloride, stearamidepropylethyldimonium ethosulphate, stear Luamidopropyldimethyl (myristyl acetate) ammonium chloride, stearamidepropyldimethylcetearylammonium tosylate, stearamidepropyldi Cationic surfactants such as methylammonium chloride and stearamidepropyldimethylammonium lactate, glycerin fatty acid esters (glyceryl monoundecylenate, glyceryl diundecylenate, glyceryl monomyristate, glyceryl dimyristate, glyceryl monopalmitate, diester Glyceryl palmitate, glyceryl monostearate, glyceryl distearate, glyceryl monooleate, mono-cotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, glyceryl monostearate, α, α'-glycolic acid pyroglutamate, monostearate Acid glycerin malic acid, etc.), polyglycerin fatty acid ester (diglyceryl monomyristic acid, diglyceryl dimyristic acid, trimyristic acid) Glyceryl, diglyceryl monopalmitate, diglyceryl dipalmitate, diglyceryl tripalmitate, diglyceryl monostearate, diglyceryl distearate, diglyceryl tristearate, diglyceryl monooleate, diglyceryl dioleate, triolein Diglyceryl acid, tetraglyceryl monopalmitate, tetraglyceryl dipalmitate, tetraglyceryl tripalmitate, tetraglyceryl tetrapalmitate, tetraglyceryl pentapalmitate, tetraglyceryl monostearate, tetraglyceryl distearate, tetraglyceryl tristearate , Tetraglyceryl tetrastearate, tetraglyceryl pentastearate, tetraglyceryl monooleate, tetraoleic acid tetra Riseriru trioleate tetraglyceryl, tetraoleate tetraglyceryl, penta oleate tetraglyceryl monopalmitate hexaglyceryl dipalmitate hexaglyceryl, hexaglyceryl tripalmitate, Tetoraparumichin acid Hekisaguri
Seryl, hexaglyceryl pentapalmitate, hexaglyceryl monostearate, hexaglyceryl distearate, hexaglyceryl tristearate, hexaglyceryl tetrastearate, hexaglyceryl pentastearate, hexaglyceryl monooleate, hexaglyceryl dioleate, triolein Hexaglyceryl acid, hexaglyceryl tetraoleate, hexaglyceryl pentaoleate, decaglyceryl monopalmitate, decaglyceryl dipalmitate, decaglyceryl tripalmitate, decaglyceryl tetrapalmitate, decaglyceryl pentapalmitate, decaglyceryl hexapalmitate Glyceryl, decaglyceryl heptapalmitate, decaglyceryl octapalmitate, decagli nonapalmitate Ril, decaglyceryl decapalmitate, decaglyceryl monostearate, decaglyceryl distearate, decaglyceryl tristearate, decaglyceryl tetrastearate, decaglyceryl pentastearate, decaglyceryl hexastearate, decaglyceryl heptearate, octa Decaglyceryl stearate, decaglyceryl nonastearate, decaglyceryl decastearate, decaglyceryl monooleate, decaglyceryl dioleate, decaglyceryl trioleate, decaglyceryl tetraoleate, decaglyceryl pentaoleate, decaglyceryl hexaoleate Glyceryl, decaglyceryl heptaoleate, decaglyceryl octaoleate, decaglyceryl nonaoleate, decagreate decag Seryl, monohydroxystearic acid decaglyceryl, dihydroxystearic acid decaglyceryl, trihydroxystearic acid decaglyceryl, tetrahydroxystearic acid decaglyceryl, pentahydroxystearic acid decaglyceryl, hexahydroxystearic acid decaglyceryl, heptahydroxystearic acid decaglyceryl, Decaglyceryl octahydroxystearate, decaglyceryl nonahydroxystearate, decaglyceryl decahydroxystearate, hexaglyceryl polyricinoleate, decaglyceryl polyricinoleate, polyoxyethylene glyceryl monostearate, polyoxyethylene glyceryl distearate, monoolein Acid polyoxyethylene glycerin, monomyristic acid polyoxyethylene Lenglycerin, etc.), polyoxyethylene glycerin fatty acid ester (polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate, etc.), sorbitan fatty acid ester (sorbitan monolaurate, monoolein) Sorbitan acid, sorbitan sesquioleate, sorbitan trioleate, sorbitan monopalmitate, sorbitan monostearate, sorbitan distearate, sorbitan dioleate, sorbitan monopalmitate, sorbitan tristearate, sorbitan trioleate, penta-2- Diglycerol sorbitan ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate, polyoxy monooleate Tylene sorbitan, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan trioleate, polyoxyethylene sorbitan pentaoleate, etc., propylene glycol fatty acid ester ( Propylene glycol monooctanoate, propylene glycol monodecanoate, propylene glycol monostearate, etc.), sucrose fatty acid ester (monolauric acid sucrose ester, dilauric acid sucrose ester, monopalmitic acid sucrose ester, dipalmitic acid sucrose ester, Monostearic acid sucrose ester, distearic acid sucrose ester, etc.), dextrin fatty acid ester (such as dextrin palmitate), Zushi oil fatty acid alkanolamide, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid Monoisostearic acid diester, polyoxyethylene hydrogenated castor oil maleic acid, polyoxyethylene alkyl ether (alkyl polyglucoside, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene behenyl ether, polyoxyethylene oleyl ether, polyoxy Ethylene lauryl ether, polyoxyethylene-2-octyldecyl ether, polyoxyethylene cholestanol ether, etc.), polyoxye Tylene alkyl phenyl ether (polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), polyoxyethylene fatty acid ester (polyethylene glycol monooleate, polyethylene glycol monostearate, polyethylene glycol monolaurate, etc.), lanolin derivatives (poly Oxyethylene lanolin, polyoxyethylene lanolin alcohol, polyoxyethylene sorbitol lanolin, etc.), POE / POP-alkyl ether (POE / POP-cetyl ether, POE / POP-2-decyltetradecyl ether, POE / POP-monobutyl ether), POE / POP-hydrogenated lanolin, POE / POP-glycerin ether, Tetronic, etc.), alkanolamide (coconut oil fat) Nonionic surfactants such as diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc., betaine-type amphoteric surfactants (2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethyl) Betaine aminoacetate, undecylcarboxymethoxyethylcarboxymethylimidazolinium betaine sodium, undecylhydroxyethylimidazolinium betaine sodium, undecyl-N-hydroxyethyl-N-carboxymethylimidazolinium betaine, alkyldiaminoethylglycine hydrochloride solution, Stearyl dihydroxyethyl betaine, stearyl dimethylaminoacetic acid betaine, stearyl dimethyl betaine sodium solution, coconut oil alkyl-N-carboxyl Ethyl-N-hydroxyethylimidazolinium betaine sodium, coconut oil alkylbetaine, coconut oil alkyldimethylaminoacetic acid betaine, coconut oil fatty acid amidopropyl betaine, coconut oil fatty acid-N-carboxymethoxyethyl-N-carboxyethylimidazolinium betaine Sodium, N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, N-cocoyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, lauryldimethylaminoacetic acid hydroxysulfobetaine, coconut oil alkyldimethyl Aminoacetate hydroxysulfobetaine, laurylaminopropionate triethanolamine, β-laurylaminopropionate sodium, laurate amidepropi Dimethylaminoacetic acid betaine, lauric acid amidopropyl dimethylaminoacetic acid hydroxysulfobetaine, coconut oil fatty acid amidopropyl dimethylaminoacetic acid hydroxysulfobetaine, palm oil fatty acid amidopropyldimethylaminoacetic acid hydroxysulfobetaine, coconut oil fatty acid amidopropyl dimethylaminoacetic acid betaine, Palm oil fatty acid amidopropyldimethylaminoacetic acid betaine, lauryl N-carboxymethoxyethyl-N-carboxymethylimidazolinium disodium dodecanoyl sarcosine, lauryl diaminoethylglycine sodium, lauric acid amidopropyl betaine solution, lauryl sulfobetaine, lauryl hydroxysulfo Betaine, 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazoli Umbetaine, Cocodimethylcarboxymethylbetaine, Lauryldimethylcarboxymethylbetaine, Lauryldimethylalphacarboxyethylbetaine, Cetyldimethylcarboxymethylbetaine, Cetyldimethylbetaine, Laurylbis- (2-hydroxyethyl) carboxymethylbetaine, Stearylbis- (2-hydroxy Propyl) carboxymethylbetaine, oleyldimethylgamma-carboxypropylbetaine, laurylbis- (2-hydroxypropyl) alpha-carboxyethylbetaine, cocodimethylsulfopropylbetaine, stearyldimethylsulfopropylbetaine, lauryldimethylsulfoethylbetaine, laurylbis- (2 -Hydroxyethyl) sulfopropylbetaine, Levon 2000 (Sanyo) Kasei), Anon BDF (Nippon Yushi), Lonzain-CS (Lonza), Miratine CBS (Milan), Anon BL (Nippon Yushi), Lonzain 12CS (Lonza), etc.), imidazolinium type amphoteric interface Activator (bis (stearyl-N-hydroxyethylimidazoline) chloroacetic acid complex, N-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-alkyl-N-carboxymethyl-N-hydroxyethylethylenediamine, Lauryl sulfate and salts thereof, coconut oil alkyl-N-carboxyethoxyethyl-N-carboxyethyl imidazolinium disodium hydroxide, coconut oil alkyl-N-carboxymethoxyethyl-N-carboxyethyl imidazolinium disodium hydroxide, Palm oil Rukyl-N-carboxymethoxyethyl-N-carboxyethylimidazolinium disodium lauryl sulfate, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2-cocoyl-2-imidazoli Nitrohydroxide-1-carboxyethyloxy disodium salt, ovazoline 662 (Toho Chemical Co., Ltd.), Swanol AM-101 (Nikko Chemicals Co., Ltd.), Anon GLM (Nippon Yushi Co., Ltd.), aminopropionic acid type amphoteric surfactants ( Alkylaminopropionic acid such as sodium dodecylaminopropionate, alkylaminodipropionic acid, etc.), sodium dodecylaminopropanesulfonate, N-higher alkylaspartic acid or a salt thereof, coamidopropyl chloride polyethylene glycol dimonio Amphoteric such as phosphoric acid, cocamidopropyl hydroxysultain, sodium lauroyl sarcosinate, alkylamine oxide (decylamine oxide, cocoamine oxide, myristoylamine oxide, palmitoylamine oxide, alkyldimethylamine oxide, alkylamidopropylamine oxide, etc.) Surfactant, natural surfactant (lecithin, sodium caseinate, sphingolipid, saponin, mannosyl polyhydric alcohol fatty acid ester, glucosyl polyhydric alcohol fatty acid ester, galactosyl polyhydric alcohol fatty acid ester, etc. Disaccharide polyhydric alcohol fatty acid ester, oligosaccharide polyhydric alcohol fatty acid ester, etc.) and amino acid surfactants (capric acid chloride, lauric acid chlora) Id, myristic acid chloride, palmitic acid chloride, stearic acid chloride, oleic acid chloride, behenic acid chloride, coconut oil fatty acid chloride and other fatty acid chlorides and glycine, sarcosine, β-alanine, N-methyl-β-alanine, taurine, N -Reaction products with amino acids in a broad sense such as methyl taurine), silicone surfactants (silicon KF-6011 (manufactured by Shin-Etsu Chemical Co., Ltd.), KF-6012 (manufactured by Shin-Etsu Chemical Co., Ltd.), KF-6013 (Shin-Etsu Chemical Co., Ltd.) KF-6015 (manufactured by Shin-Etsu Chemical Co., Ltd.), KF-6016 (manufactured by Shin-Etsu Chemical Co., Ltd.), KF-6017 (manufactured by Shin-Etsu Chemical Co., Ltd.), X-22-4991 (manufactured by Shin-Etsu Chemical Co., Ltd.), NUC silicon L7002 (manufactured by Nihon Unicar), SH-3772C (Toray Dow Corning Silico Polyoxyalkylene-modified organopolysiloxanes such as SH-3775C (manufactured by Dow Corning Toray Co., Ltd.), ABIL EM-90 (manufactured by Goldschmidt), ABIL B9806 (manufactured by Goldschmidt), Silicon KF-602
6 (manufactured by Shin-Etsu Chemical Co., Ltd.) etc., long chain alkyl-containing polyoxyalkylene-modified organopolysiloxane, etc.), polyether-modified silicone (polyoxyethylene / methylpolysiloxane copolymer, poly (oxyethylene / oxypropylene) methylpoly) Siloxane copolymer, etc.), oxazoline-modified organopolysiloxane, alkyl-modified organopolysiloxane, styryl ketone silicone derivatives, dimethylpolysiloxane, methylphenylpolysiloxane, epoxy-modified silicone, fluorine-modified silicone, alcohol-modified silicone, alkyl-modified silicone, alkoxy Modified silicone, amino-modified silicone, ammonium-modified polymeric silicone, organopolysiloxane, methylphenylpolysiloxane, polysiloxane, poly (N- Silalkyleneimine) modified silicone, dimethylpolysiloxane, methylphenylpolysiloxane, nitrogen-containing acrylic-silicone graft copolymer, decamethylcyclopentasiloxane, fluorine-substituted alkyl-modified silicone, organopolysiloxanylsilylalkyl-modified silicone, three Cyclic diterpenecarboxylic acid modified silicone, trifluoroalkyl modified silicone, divinylpolydimethylsiloxane, dihydrogenopolydimethylsiloxane, dihydrogenopolydimethylsiloxane divinylpolydimethylsiloxane polymer, trimethylsiloxysilicic acid, polyoxypropylene / methylpolysiloxane Copolymer, ethylpolysiloxane, ethylmethylpolysiloxane, ethylphenylpolysiloxane, octamethylcyclotetrasilane Xanthone, diorganopolysiloxane, octamethylcyclotetrasiloxane, tetramethyltetraphenyltetracyclosiloxane, polyether-modified polysiloxane, amino-modified polysiloxane, epoxy-modified polysiloxane, fluorine-modified polysiloxane, alcohol-modified polysiloxane, Alkyl-modified polysiloxane, dodecamethylcyclohexasiloxane, laurylmethicone copolyol, aminoethylaminopropylsiloxane / dimethylsiloxane copolymer, silicone compounds such as eugenol-modified silicone, selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione , Hair treatment agents such as biphenamine, thianthol, quinine hydrochloride, strong ammonia water, zein, shellac, carboxymethylcellulose or alkalis thereof Film forming agents such as metal salts, hydroxypropylcellulose or phthalated derivatives or succinylated derivatives thereof, hydroxypropylcellulose acetate or phthalated derivatives or succinylated derivatives thereof, copolymers of acrylic acid compounds and methacrylic acid compounds, etc. Can be mentioned.

  In addition, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, refreshing agents, stabilizers, emulsifiers, animal / plant proteins and their degradation products, animal / plant polysaccharides and their Degradation products, animal / plant glycoproteins and their degradation products, anti-inflammatory agents, antiallergic agents, wound treatment agents, foaming agents, thickeners, enzymes, purified water (electronic water, small clusters, etc.), deodorant / A deodorant etc. can be used in combination.

  Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

Production of 3-hydroxyanthranyl palmitate
1.53 g of 3-hydroxyanthranilic acid was dissolved in 100 mL of pyridine, and 2.74 g of palmitoyl chloride was added dropwise under ice cooling. The reaction mixture was reacted at 20 ° C. for 24 hours. Methanol was added to the reaction mixture to stop the reaction, and the mixture was extracted with 200 mL of chloroform. The chloroform layer was washed with 200 mL of water three times, the solvent was distilled off under reduced pressure, and the residue was isolated and purified by silica gel chromatography. As the elution solvent, chloroform: methanol = 50: 1 was used. After purification, the solvent was distilled off to obtain the title compound 3-hydroxyanthranilic acid palmitic acid ester as a pale yellow paste (yield 45.2%).

¹ H-NMR spectrum of 3-hydroxy-anthranilic acid palmitate
¹ H-NMR (DMSO-d ₆ ): δ 9.01 ppm (COO H , br, 1H), 8.23 ppm (N H ₂ , s, 2H), 7.21 ppm (Ph H , dd, 1H), 6.84 ppm (Ph H , d, 1H), 6.35 ppm (Ph H , d, 1H), 4.22 ppm (PhOCOC H ₂ , t, 2H), 3.50 ppm (C H ₂ , m, 2H), 3.3 to 1.1 ppm (12C H ₂ , m, 24H), 0.75 ppm (C H ₃ , t, 3H)

Production of 3-hydroxyanthranilic acid-DL-α-tocopherol ester
DL-α-tocopherol 4.3 g and 3-hydroxyanthranilic acid 2 g were dissolved in dimethylformamide 30 mL and pyridine 15 mL, and diketene 1.5 mL was gradually added. The reaction temperature was adjusted to 75 ° C. in an oil bath and reacted for 3 hours. The reaction mixture was added to 500 mL of water and extracted with 500 mL of chloroform. The chloroform layer was washed three times with 500 mL of 1M hydrochloric acid and 500 mL of 1M aqueous sodium hydrogen carbonate solution. The solvent was distilled off under reduced pressure and isolated and purified by silica gel chromatography. At this time, chloroform was used as an elution solvent. After purification, the solvent was distilled off to obtain 3-hydroxyanthranilic acid-DL-α-tocopherol ester which was a pale yellow oily title compound (yield 85.1%).

¹ H-NMR spectrum of 3-hydroxyanthranilic acid-DL-α-tocopherol ester
^{1 H-NMR (DMSO-d} 6): δ11.5ppm (O H, s, 1H), 7.2~7.1ppm (Ph H, m, 3H), 5.21ppm (N H 2, s, 2H), 3.75ppm (ArC H ₂ , s, 2H), 2.60 ppm (OCC H ₃ , t, 3H), 2.10 ppm (PhC H ₃ , s, 3H), 2.05 ppm (PhC H ₃ , s, 3H), 2.01 ppm (PhC H ₃ , s, 3H), 2.05 ppm (OCC H ₂ , t, 2H), 1.80 ppm (C H , m, 1H), 1.55 ppm (C H , m, 1H), 1.38 ppm (C H , m, _{1H), 1.5~1.0ppm (8C H 2} , m, 16H), 0.7ppm (4C H 3, m, 12H)

Antioxidant test In this test, the inhibitory effect of oxidative stress on cells was tested as an index of antioxidant effect. As samples to be used in this test, 3-hydroxyanthranilic acid palmitic acid ester of Example 1 (hereinafter referred to as Example 1) and 3-hydroxyanthranilic acid-DL-α-tocopherol ester of Example 2 (hereinafter, 70% ethanol aqueous solution (denoted as Example 2) (70% EtOH), and each 70% ethanol aqueous solution and 70% ethanol aqueous solution of sodium ascorbate and DL-α-tocopherol, which have been confirmed to have an antioxidant effect, were used. . Human skin fibroblasts (normal human newborn foreskin skin fibroblasts NHDF (NB) manufactured by Kurabo Industries) are grown in 5% FBS-DMEM medium and proliferated, 1 × 10 ⁵ cells Was seeded in a 24-well culture plate. Next, 5% FBS-DMEM medium and 10 ppm of the test sample were added to the culture plate, and cultured at 37 ° C. for 48 hours under 5% CO ₂ culture conditions. Next, remove the medium from the culture plate, add 50 mM Hanks' buffer (pH 7.2) containing 20 mM hydrogen peroxide, and leave it at 37 ° C for 1 hour under 5% CO ₂ conditions. Thus, oxidative stress was applied to the cells. In addition, the system which left still in 50 mM Hanks' buffer which does not contain hydrogen peroxide as a system which does not give oxidative stress and does not receive inhibition of cell growth was also performed simultaneously. Next, the buffer was removed, 5% FBS-DMEM medium was added, and cultured again for 24 hours under the above culture conditions. Next, after removing the medium and washing the cells in the plate with 1 mL of 25 mM HEPES buffer, 400 μL of Cell Counting Kit-8 (manufactured by Dojindo) diluted 10-fold with 25 mM HEPES buffer was added, The reaction was carried out for 1 hour under the condition of 5% CO ₂ . The absorbance at a wavelength of 450 nm of the cell solution in the plate was measured with a microplate reader (Labsystems Multiskan MS-UV). Since the absorbance and the cell concentration are in a proportional relationship, in this test, the cell proliferation was indicated by the absorbance value. The results are shown in FIG.

Results of Antioxidation Test As a result of testing the antioxidative effect of each test sample on cells, specifically, the oxidative stress inhibitory effect on cells, as shown in FIG. 1, 70% ethanol aqueous solution, sodium ascorbate and DL-α- Compared with tocopherol, the system to which the 3-hydroxyanthranilic acid derivatives of Example 1 and Example 2 were added showed a high OD450nm value, indicating a high cell proliferation. Therefore, it was found that the 3-hydroxyanthranilic acid derivative of the present invention has an oxidative stress inhibitory action on cells and has an antioxidant action based on the action.

Whitening test 1
In this test, melanin production inhibitory action was tested as an index of whitening action. As samples to be used in this test, Examples 1 and 2 and 70% ethanol aqueous solutions of arbutin and DL-α-tocopherol in which whitening action has been confirmed, and 3-hydroxyanthranyl in which whitening action has not been confirmed. An acid, 70% aqueous ethanol solution was used. The concentration of the test sample for B16 melanoma cells, which are test cells, was all adjusted to 10 μg / mL. B16 melanoma cells 5 × 10 ⁴ cells were pre-cultured in a 5% FBS-MEM liquid medium (60 mm petri dish) at 37 ° C. for 24 hours, and then the medium was removed. Next, theophylline-containing 5% FBS-MEM liquid medium and a sample having the above concentration were added to the pre-cultured B16 melanoma cells, and cultured at 37 ° C. for 120 hours. Then, after removing the medium and collecting the cells using the Tripsin / EDTA solution, adding ether-ethanol mixture (1: 3), centrifuging at 2000 rpm, and removing the solvent, the collected cells The contained non-melanin material was removed. Next, the cells were heated at 90 ° C. in 1N NaOH solution containing 10% DMSO to extract melanin in the cells. The absorbance at 420 nm of the obtained melanin extract was measured, and the obtained numerical value was defined in this test as the amount of melanin produced. The results are shown in FIG.

Results of whitening effect test 1 As a result of testing the melanin production inhibitory action of each test sample, as shown in FIG. 2, compared with 70% ethanol aqueous solution, 3-hydroxyanthranilic acid, arbutin and DL-α-tocopherol, In the system to which the 3-hydroxyanthranilic acid derivative of Example 1 and Example 2 was added, a low absorbance value was obtained, indicating a low melanin production amount. Therefore, it was found that the 3-hydroxyanthranilic acid derivative of the present invention has a melanin production inhibitory action and a whitening action based on the action.

Whitening test 2
In this test, the pigmentation inhibitory effect using colored guinea pigs was tested as an index of whitening effect. As samples to be used in this test, Examples 1 and 2 and 70% ethanol aqueous solution and 70% ethanol aqueous solution each having 1.0% concentration of 3-hydroxyanthranilic acid for which whitening action was not confirmed were used. The dorsal skin hair of a test animal, WM guinea pig (5 animals used for 30-week-old 1 test system) was shaved and allowed to stand for 3 hours for relaxation. Next, a light-shielding mount was applied to the back skin of the test animal, and UV-B 250 mJ / cm ² (Toshiba FL20S · E40 lamp) was irradiated to 4 places in a 2 × 2 cm section. The same operation was continued once a day for 4 days. After the UV irradiation was completed, 20 μL of the test sample was applied to the UV irradiation site of the dorsal skin once a day. Then, the L value of the ultraviolet region was measured using a color difference meter (Minolta color difference meter CR-200). The L value was measured from the end of irradiation until 14 days later, and the ΔL value was calculated from the difference between each L value obtained and the L ₀ value obtained by measuring the same skin site at the time of shaving. The results are shown in FIG. (ΔL value = measured L value-L ₀ value)

Results of Whitening Test 2 As a result of testing the pigmentation inhibitory action of each test sample, as shown in FIG. 3, compared with 70% ethanol aqueous solution and 3-hydroxyanthranilic acid, Example 1 and Example 2 Low Δ values and low gradients were measured in the system to which 3-hydroxyanthranilic acid derivative was added, and it was confirmed that the increase in skin color difference due to pigmentation of colored guinea pigs induced by ultraviolet irradiation was significantly suppressed. . Therefore, it was found that the 3-hydroxyanthranilic acid derivative of the present invention has a pigmentation-inhibiting action and a whitening action based on the action.

Time-dependent stability test of 3-hydroxyanthranilic acid derivative In this test, the time-dependent stability of the 3-hydroxyanthranilic acid derivative of the present invention was tested. As samples to be used for this test, 70% ethanol aqueous solutions of Examples 1 and 2 and 3-hydroxyanthalanyl acid each having a concentration of 20.0% were used. 10 mL of a test sample was placed in a 20 mL transparent screw tube, stoppered, and allowed to stand for 3 months at 22-25 ° C. in a place where it was irradiated with sunlight. Then, the absorbance of each sample at a wavelength of 470 nm after the first day of the test day and after the lapse of 3 months was measured, and the presence or absence of precipitates was observed with the naked eye. The results are shown in Table 1.

  As a result of testing the stability over time of each test sample, as shown in Table 1, in 3-hydroxyanthranilic acid, remarkable color change and precipitation were observed after 3 months. In the 3-hydroxyanthranilic acid derivatives of 1 and Example 2, there was almost no change in color tone, and no precipitate was observed. Therefore, it was found that the 3-hydroxyanthranilic acid derivative of the present invention has excellent temporal stability.

(Production Examples) Production of Various Cosmetic Compositions, External Pharmaceutical Compositions and Food Compositions Various cosmetic compositions, external pharmaceutical compositions and food compositions according to the present invention were produced. Although the formulation example is shown below, this invention is not necessarily limited to these.

(Production Example 1) Milk mass%
3-hydroxyanthranilic acid-DL-α-tocopherol 4.0
Squalane 5.0
Olive oil 5.0
Jojoba oil 5.0
Cetyl alcohol 1.5
Glycerol monostearate 2.0
Polyoxyethylene (20) cetyl ether 3.0
Polyoxyethylene (20) soorbitan monooleate 2.0
1,3-butylene glycol 1.0
Glycerin 2.0
P-Hydroxybenzoate ester
Residue with 100 purified water

(Production Example 2) Toner lotion% by mass
3-hydroxyanthranilic acid stearate 2.0
Sodium glutamate 1.0
1,3-butylene glycol 6.0
Glycerin 5.0
Polyethylene glycol 400 3.0
Olive oil 0.5
Polyoxyethylene (20) sorbitan monostearate 2.5
Polyoxyethylene (5) oleyl alcohol ether 0.5
Ethanol 10.0
Perfume Appropriate amount Dye Appropriate amount Phenoxyethanol 0.1
Citric acid 1.0
Sodium citrate 1.2
Residue with 100 purified water

(Production Example 3) Lotion Mass%
3-hydroxyanthranilic acid hydroxymyristate 2.5
Glycerin 3.0
1,3-butylene glycol 5.0
Ethanol 15.0
Polyoxyethylene (20) oleyl alcohol ether 1.5
Iron oxide 0.2
Zinc oxide 0.5
Kaolin 2.0
Trehalose 2.0
Dextrin 0.5
Photosensitive element 201 Appropriate amount Photosensitive element 401 Appropriate amount Fragrance Appropriate amount
Residue with 100 purified water

(Production Example 4) Lotion Mass%
3-hydroxyanthranilic acid isopalmitate 2.0
Glycerol monostearate3.0
Sodium citrate 1.0
Dipropylene glycol 5.0
Raffinose 1.0
Ethanol 5.0
Phenoxyethanol 0.2
Pectin 0.01
Xanthan gum 0.05
Acetylglucosamine 0.05
Diisopropylamine dichloroacetic acid 0.2
γ-amino-β-hydroxybutyric acid 0.2
Sodium hyaluronate 0.001
Allantoin 0.2
N-menthyl glyceryl ether 0.2
Dipotassium glycyrrhizinate 0.2
Decarboxycarnosine hydrochloride 0.05
Perfume
Residue with 100 purified water

(Production Example 5) Cream mass%
3-hydroxyanthranilic acid-DL-α-tocotrienol ester 5.0
Stearic acid 2.0
Glycerol monostearate2.0
Cetanol 3.0
Cholesterol 0.5
Vaseline 2.0
Squalane 10.0
Liquid paraffin 10.0
Dimethylpolysiloxane 1.0
Sodium glutamate 2.0
Glycerin 5.0
Dipropylene glycol 3.0
Nicotinamide 1.0
Methyl paraoxybenzoate 0.1
Butyl paraoxybenzoate 0.1
Perfume
Residue with 100 purified water

(Production Example 6) Face wash mass%
3-hydroxyanthanilic acid stearate hydrochloride 1.0
Sodium aspartate 1.0
Methoxycinnamic acid 1.0
Myristic acid 25.0
Stearic acid 5.0
Tallow fatty acid 5.0
Propylene glycol 10.0
Potassium hydroxide 6.0
Palm oil fatty acid diethanolamide 6.0
Glycerol 1.0
1,3-butylene glycol 1.0
Dipotassium glycyrrhetinate 1.0
Preservative 0.1
Perfume
Residue with 100 purified water

(Production Example 7) Body soap mass%
3-Hydroxyanthranilic acid-DL-β-tocopherol Mg salt 1.2
Sodium citrate 2.0
N-acetylglutamic acid 1.0
Potassium laurate 15.0
Potassium myristate 5.0
Propylene glycol 5.0
Sorbitol 3.0
Polyethylene powder 0.5
Hydroxypropyl chitosan solution 0.5
Preservative appropriate amount
pH adjuster appropriate amount perfume appropriate amount
Residue with 100 purified water

(Production Example 8) Powder foundation mass%
3-hydroxyanthranilic acid palmitic acid sodium salt 3.0
Silicone-treated mica 25.0
Sericite 17.0
Hydrophobic treated silica 20.0
Titanium oxide 20.0
Spherical alumina powder 4.0
Dimethylpolysiloxane 4.0
Methylphenylpolysiloxane 1.0
Vaseline 3.0
Octyl methoxycinnamate 3.0
Sorbitan diisostearate 1.0
Antioxidant Appropriate perfume Appropriate paraoxybenzoic acid Appropriate
Talc remaining

(Production Example 9) Emulsified liquid foundation mass%
3-hydroxyanthranilic acid-DL-α-tocopherol 3.2
Sodium glutamate 1.5
Octamethylcyclotetrasiloxane 20.0
Polyoxyethylene (6) oleyl ether 4.0
Polyoxyethylene hydrogenated castor oil 3.0
Aluminum monostearate 0.01
Liquid paraffin 12.0
Dimethylpolysiloxane 5.0
12-hydroxystearic acid 1.0
Nylon powder 4.5
Black iron oxide 1.5
Yellow iron oxide 3.0
Titanium oxide 5.0
Red iron oxide 2.0
Butyl paraoxybenzoate 0.2
Sorbitol 7.0
Residue with 100 purified water

(Production Example 10) Lipstick mass%
3-Hydroxyanthranilic acid isostearate 2.5
Paraffin wax 5.0
Ceresin 5.0
Candelilla wax 2.0
Microcrystalline wax 1.0
Polyethylene wax 1.0
Ethylene propylene copolymer 1.0
Hydrogenated polyisobutene 10.0
Diisostearyl malate 15.0
Isotridecyl isononanoate 12.0
Neopentyl glycol dicaprate8.0
Octyldodecanol 3.0
Squalane 5.0
Phytosteryl oleate 3.0
Methylphenylpolysiloxane 3.0
DL-α-Tocopherol 0.1
Red No. 201 0.4
Red No. 202 0.2
Yellow No.4 0.5
Mica titanium 7.0
Glyceryl trioctanoate

(Production Example 11) Hair shampoo
3-Hydroxyanthranilic acid-DL-γ-tocopherol ester 1.0
Potassium citrate 1.5
N-lauroylmethyl taurine sodium 7.0
Lauroyl sarcosine sodium 6.0
Lauryldimethylbetaine 2.5
Palm oil fatty acid diethanolamide 4.0
Propylene glycol 5.0
2-phenoxyethanol 1.0
Hydroxyethyl cellulose 0.5
Residue with 100 purified water

(Production Example 12) Hair rinse Mass%
3-hydroxyanthranilic acid isopalmitate 1.5
Sodium pyrrolidonecarboxylate 1.0
Polyoxyethylene / methylpolysiloxane copolymer 2.0
Stearyltrimethylammonium chloride 1.0
Cetostearyl alcohol 3.0
Polyoxyethylene hydrogenated castor oil 1.0
Cationized cellulose 1.0
Isostearyl myristate 1.0
Propylene glycol 5.0
Hydroxybenzophenone 0.1
Perfume
Residue with 100 purified water

(Production Example 13) Hair Treatment Mass%
3-Hydroxyanthranilic acid laurate ester 2.0
Behenic acid 5.0
Stearic acid 3.0
Cetyltrimethylammonium chloride 8.5
Diallyl chloride (12-18) dimethylammonium 0.5
Cationized keratin hydrolyzate 0.2
Ceramide 3 0.1
Amino-modified silicone emulsion 0.2
Dipentaerythritol fatty acid ester 0.3
Hydroxymethoxybenzophenone sulfonic acid 0.3
Diethylene glycol monoethyl ether 1.0
Benzyloxyethanol 0.5
Hydroxyethyl cellulose 0.4
Sodium citrate 2.0
Perfume
Residue with 100 purified water

(Production Example 14) Hair nourishing and hair restorer
3-Hydroxyanthranilic acid-DL-α-tocopherol ester 5.0
Sodium glutamate 2.0
Ethanol 60.0
Pepper tincture 0.5
Aloe extract 3.0
Resorcin 0.5
Dipotassium glycyrrhizinate 0.5
Carboxymethylchitin 0.5
Decamethylcyclopentasiloxane 0.1
Arginine 0.25
Glutamine 0.25
Antibacterial agent appropriate amount perfume appropriate amount
Residue with 100 purified water

(Production Example 15) Bath agent mass%
3-hydroxyanthranilic acid stearate Ca salt 2.4
Sodium bicarbonate 60.0
Borax 5.0
Sodium hyaluronate 1.0
Hydroxypropyl methylcellulose 1.0
Karin extract 5.0
Antibacterial agent appropriate amount perfume appropriate amount
Residual sodium sulfate 100

(Production Example 16) Ointment Mass%
3-hydroxyanthranilic acid-DL-β-tocotrienol ester 8.0
l-Menthol 3.0
DL-Camphor 0.5
Propylene glycol 15.0
Carboxyvinyl polymer 1.0
Hydroxyethyl cellulose 0.1
Lauro Macrogol 1.5
Triethanolamine 0.7
Purified water 25.0
Ethanol 100 residue

(Production Example 17) Patch%
3-Hydroxyanthranilic acid oleic acid ester 6.0
l-Menthol 3.0
DL-Camphor 1.5
Polyacrylic acid 4.5
Sodium polyacrylate 1.5
Sodium carboxymethylcellulose 4.0
Glycerol 20.0
Sorbitol 5.0
Polyoxyethylene nonylphenyl ether 0.5
Kaolin 5.0
Castor oil 1.0
The residue obtained by dissolving, dispersing and kneading the remaining components as purified water 100 was spread on a polyester non-woven fabric so as to be 1000 g per 1 m ² to produce a patch.

(Production Example 18) Coating preparation Impregnated with a prescription liquid in which gauze or liniment cloth is mixed with 3-hydroxyanthranilic acid-DL-α-tocopherol ester hydrochloride and a moisturizer, anti-inflammatory agent, cell activator, antioxidant, etc. And attach to the wound. Further, an application method in which these are directly applied locally and coated with gauze or the like may be adopted.

(Production Example 19) Capsule
3-hydroxyanthranilic acid palmitic acid sodium salt 20.0 g
Magnesium ascorbate 0.5g
DL-α-tocopherol acetate 0.5g
Silicone oil 30.0g
Tween 80 0.05g
Corn starch 48.95g
The above ingredients were mixed uniformly and 200 mg was filled into a gelatin capsule to produce a capsule.

(Production Example 20) Capsule
3-hydroxyanthranilic acid
-DL-α-Tocopherol ester hydrochloride 15.0g
Starch 60.0g
Mannitol 10.0g
Calcium bicarbonate 5.0g
Polyvinylpyrrolidone 20.0g
The above ingredients were mixed uniformly and 200 mg was filled into a gelatin capsule to produce a capsule.

(Production Example 21) Tablet
3-hydroxyanthranilic acid linoleic acid ester Mg salt 100.0mg
Cornstarch 50.0mg
Hydroxypropyl methylcellulose 150.0mg
Carboxymethylchitin 30.0mg
The above ingredients were uniformly mixed and tableted to produce a tablet.

(Production Example 22) Tablet
3-hydroxyanthranilic acid isostearate Ca salt 100.0mg
Corn starch 80.0mg
Methylcellulose 40.0mg
Magnesium stearate 20.0mg
Talc 10.0mg
The above ingredients were uniformly mixed and tableted to produce a tablet.

(Production Example 23) Granule
3-hydroxyanthranilic acid
-DL-α-Tocotrienol ester hydrochloride 50.0mg
Carboxymethylcellulose 180.0mg
Propylene glycol 20.0mg
Sodium alginate 30.0mg
Sucrose 10.0mg
The above ingredients were uniformly mixed and granulated to produce granules.

(Production Example 24) Granule
3-hydroxyanthranilic acid
-DL-α-Tocopherol ester sulfate 60.0mg
Carboxymethylcellulose 180.0mg
Sodium alginate 30.0mg
Erythritol 10.0mg
Citric acid 5.0mg
The above ingredients were uniformly mixed and granulated to produce granules.

(Production Example 25) Syrup
3-hydroxyanthranilic acid dihydroxystearate ester 2.0
Lecithin 2.0
Sucrose 5.0
Sorbitol 1.0
Sodium citrate 0.5
Sodium glutamate 0.5
Perfume
The remainder of purified water 100 The above ingredients were mixed uniformly to produce a syrup.

(Production Example 26) Syrup
3-hydroxyanthranilic acid hydroxymyristate 1.0
Ascorbic acid glucoside 0.5
Silk extract 0.2
Coganebana extract 0.2
Sucrose 2.0
Sodium alginate 0.2
Perfume
The remainder of purified water 100 The above ingredients were mixed uniformly to produce a syrup.

It is a figure which shows the effect | action with respect to the oxidative stress of a 3-hydroxyanthranilic acid derivative. It is a figure which shows the effect | action with respect to melanin production of a 3-hydroxyanthranilic acid derivative. It is a figure which shows the effect | action with respect to mouse | mouth pigmentation of a 3-hydroxyanthranilic acid derivative.

Claims (15)

3-hydroxyanthranilic acid derivatives represented by the following formulas (1) to (3) or pharmaceutically acceptable salts thereof.

[R ¹ in the above formula (1) represents a linear or branched alkyl group, alkenyl group or alkynyl group having 9 to 23 carbon atoms. ]

[R ^{2 to} R ⁴ in the above formula (2) each independently represent a hydrogen atom or a methyl group. ]

[R ^{5 to} R ⁷ in the above formula (3) each independently represent a hydrogen atom or a methyl group. ] 3-hydroxyanthranilic acid pelargonic acid ester, 3-hydroxyanthranilic acid isononanoic acid ester, 3-hydroxyanthranilic acid caprylic acid ester, 3-hydroxyanthranilic acid capric acid ester, 3-hydroxyanthranilic acid neodecanoic acid ester, 3-hydroxyanthranilic acid ester Undecanoic acid ester, 3-hydroxyanthranilic acid undecylenic acid ester, 3-hydroxyanthranilic acid lauric acid ester, 3-hydroxyanthranilic acid myristic acid ester, 3-hydroxyanthranilic acid myristoleic acid ester , 3-hydroxyanthranilic acid isopalmitic acid ester , 3-hydroxyanthranilic acid palmitoleic acid ester, 3-hydroxyanthranilic acid margaric acid ester, 3-hydroxyanthranilic acid stearic acid ester 3-hydroxyanthranilic acid isostearic acid ester, 3-hydroxyanthranilic acid oleic acid ester, 3-hydroxyanthranilic acid linoleic acid ester, 3-hydroxyanthranilic acid linolenic acid ester, 3-hydroxyanthranilic acid linolenic acid ester, 3-hydroxy The 3-hydroxyanthranilic acid derivative according to claim 1, which is at least one selected from anthranilic acid arachinic acid ester, 3-hydroxyanthranilic acid behenic acid ester, and 3-hydroxyanthranilic acid erucic acid ester Pharmacologically acceptable salt.   3-hydroxyanthranilic acid-D-α-tocopherol ester, 3-hydroxyanthranilic acid-D-β-tocopherol ester, 3-hydroxyanthranilic acid-D-γ-tocopherol ester, 3-hydroxyanthranilic acid-D-δ-tocopherol Esters, 3-hydroxyanthranilic acid-L-α-tocopherol ester, 3-hydroxyanthranilic acid-L-β-tocopherol ester, 3-hydroxyanthranilic acid-L-γ-tocopherol ester, 3-hydroxyanthranilic acid-L-δ -Tocopherol ester, 3-hydroxyanthranilic acid-DL-α-tocopherol ester, 3-hydroxyanthranilic acid-DL-β-tocopherol ester, 3-hydroxyanthranilic acid-DL-γ-tocopherol ester, 3-hydroxyanthranilic acid-DL -δ-Tocopherol ester, 3-hydroxyanthranyl -D-α-tocotrienol ester, 3-hydroxyanthranilic acid-D-β-tocotrienol ester, 3-hydroxyanthranilic acid-D-γ-tocotrienol ester, 3-hydroxyanthranilic acid-D-δ-tocotrienol ester, 3-hydroxy Anthranilic acid-L-α-tocotrienol ester, 3-hydroxyanthranilic acid-L-β-tocotrienol ester, 3-hydroxyanthranilic acid-L-γ-tocotrienol ester, 3-hydroxyanthranilic acid-L-δ-tocotrienol ester, 3 -Hydroxyanthranilic acid-DL-α-tocotrienol ester, 3-hydroxyanthranilic acid-DL-β-tocotrienol ester, 3-hydroxyanthranilic acid-DL-γ-tocotrienol ester, 3-hydroxyanthranilic acid-DL-δ-tocotrienol ester At least one selected from The 3-hydroxyanthranilic acid derivative or a pharmacologically acceptable salt thereof according to claim 1, which is as described above.   A whitening agent comprising at least one selected from the 3-hydroxyanthranilic acid derivatives according to claim 1 or 3 or a pharmaceutically acceptable salt thereof as an active ingredient.   The whitening agent according to claim 4, which is a melanin production inhibitor.   The whitening agent according to claim 4, which is a pigmentation inhibitor.   An antioxidant comprising at least one selected from the 3-hydroxyanthranilic acid derivatives according to claim 1 or 3 or a pharmaceutically acceptable salt thereof as an active ingredient.   The antioxidant according to claim 7, which is an oxidative stress inhibitor.   A cosmetic composition comprising at least one selected from the 3-hydroxyanthranilic acid derivative according to claim 1 or 3 or a pharmaceutically acceptable salt thereof.   A cosmetic composition comprising at least one selected from the whitening agents and antioxidants according to claim 4.   The cosmetic composition according to claim 9, wherein the cosmetic composition is a skin cosmetic composition. An external pharmaceutical composition comprising at least one selected from the 3-hydroxyanthranilic acid derivatives according to claim 1 or 3 or a pharmacologically acceptable salt thereof.   An external pharmaceutical composition comprising at least one selected from the whitening agents and antioxidants according to claims 4 to 8.   A food composition comprising at least one selected from the 3-hydroxyanthranilic acid derivatives or pharmacologically acceptable salts thereof according to claim 1.   A food composition comprising at least one selected from the antioxidants according to claim 7.

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