JP5518302B2 - Method for sustained release of hydrophobic substances from polymer micelles - Google Patents

Description

  The present invention relates to a method for easily and slowly releasing a substance from a polymer micelle encapsulating a hydrophobic substance.

  Conventionally, in order to efficiently introduce hydrophobic substances such as hydrophobic drugs and active ingredients into humans and other mammals, a method in which a hydrophobic substance is supported on liposomes or nanoparticles, or an emulsion containing a hydrophobic substance As a technique to be particularly noted, there is a method in which a hydrophobic substance is encapsulated in a polymer micelle by a block copolymer having a hydrophobic region and a hydrophilic region. Specifically, the hydrophobic substance can be stabilized and introduced into the living body by encapsulating the hydrophobic substance in a block copolymer composed of a hydrophilic segment made of polyalkylene glycol and a hydrophobic segment made of amino acid. It is possible (patent documents 1 to 3).

International Publication WO2007 / 066781 International Publication WO2007 / 102608 International Publication WO2007 / 136134

In particular, by using polymer micelles composed of block copolymers composed of hydrophilic segments composed of the above polyalkylene glycols and hydrophobic segments composed of amino acids, the active ingredients for pharmaceuticals or cosmetics are dispersed and diffused into the skin tissue. In addition, it has been reported that the effect of the active ingredient can be sufficiently exerted by accumulation (Patent Document 4).

International Publication WO2008 / 026766

  However, in the above block copolymer, the hydrophobic interaction in the hydrophobic segment, which is the region carrying the hydrophobic substance, is very strong. Therefore, in the step of the process of introduction into the preparation or in vivo, the polymer Although micelles continue to hold hydrophobic substances very stably, the release of hydrophobic substances out of micelles was slow, but the performance was not satisfactory. . Therefore, in order to improve the efficiency of introducing a hydrophobic substance into a living body and the expression of the effect, it is necessary to improve the sustained release of the hydrophobic substance supported on the polymer micelle.

  Accordingly, an object of the present invention is to develop a method for improving the sustained release property of a hydrophobic substance encapsulated in polymer micelles, which has not been found in the past, to the outside of the micelles.

  The present inventors are a polymer micelle including a hydrophobic substance and one or more compounds selected from glycerin, diglycerin, butylene glycol, dipropylene glycol, propylene glycol, polypropylene glycol, pentylene glycol and hexylene glycol. By coexisting, it has been found that the sustained release of a hydrophobic substance outside the micelles can be remarkably improved as compared with the use of conventional polymer micelles alone. This phenomenon is due to the hydrophobic interaction between the hydrophobic segment molecules of the block copolymer that the polymer micelle has to carry the hydrophobic substance, and these compounds weaken the interaction and create some voids between the molecules. It is caused by making it. Accordingly, the present invention provides a method for improving the sustained release of a hydrophobic substance encapsulated in a polymer micelle, and appropriately adjusts the balance between the sustained release and support of the hydrophobic substance possessed by the polymer micelle. It is possible to do.

  By the method of the present invention, the hydrophobic substance encapsulated in the polymer micelle is easily and gradually released out of the micelle. In addition, glycerin, diglycerin, butylene glycol, dipropylene glycol, propylene glycol, polypropylene glycol, pentylene glycol or hexylene glycol, which are the main parts of the present invention, are allowed to coexist with polymer micelles, thereby improving the sustained release property. As for the stable loading of the hydrophobic substance, which is a feature of the conventional technology, the hydrophobic substance is difficult to be sustainedly released in a preserved preparation or the like, as in the case of conventional polymer micelles, due to the degree of voids caused by these compounds. The structure of the polymer micelle exhibiting sufficient supportability is maintained.

  The copolymer used in forming the polymer micelle of the present invention is a block copolymer represented by the following formulas (1) to (2), and more specifically, a block copolymer comprising a hydrophilic segment and a hydrophobic segment. It is.

In each of the above formulas, R ¹ and R ³ each independently represent a hydrogen atom or an optionally protected lower alkyl group substituted or unsubstituted, and R ² represents a hydrogen atom, saturated or _C 1 _{-C 29} aliphatic carbonyl group or unsaturated represents an arylcarbonyl group, ^{R 4} is hydroxyl, _C 1 _{-C 30} aliphatic oxy group or an aryl saturated or unsaturated - represents a lower alkyl group, ^{R 5} represents a hydrogen atom, a phenyl group, C ₁ -C ₈ alkyl group or a benzyl group (wherein, R ⁵ can be arbitrarily selected in each amino acid unit in one block copolymer. also, the hydrogen atoms in R ⁵ is Occupying 0 to 60% of the whole amino acid unit, and if present, it is present at random.), L ¹ and L ² each independently represent a linking group, and n is 1 It is an integer of 0 to 2500, x is an integer of 10 to 300, and y represents an integer of 1 or 2.

The lower alkyl group in R ¹ and R ³ in the above formula represents a straight or branched alkyl group having 7 or less carbon atoms, preferably 4 or less, specifically a methyl group, an ethyl group, or a propyl group. , Isopropyl group, butyl group and isobutyl group. Examples of the functional group that may be protected include a hydroxyl group, an acetal, a ketal, an aldehyde, and a sugar residue. The sugar residue can be selected from monosaccharides, disaccharides, oligosaccharides and the like, and is not particularly limited. Examples include galactosyl glucoside.

L ¹ and L ² in the above formulas each independently represent a linking group, and are not limited and vary depending on the production method of the block copolymer. Specifically, L ¹ represents —NH—, —O—, —O—Z—NH—, —CH ₂ —, —O—Z—S—Z—, and —OCO—Z—NH— (in the notation). Z is selected from the group consisting of C _{1 to} C ₄ alkylene groups.) L ² is —CO—, —OCO—Z—CO—, and —NHCO—Z—CO— (Z in the notation is And a group selected from the group consisting of C _{1 to} C ₄ alkylene groups).

  Among the block copolymers represented by the above formulas used in the present invention, particularly preferred block copolymers are polyethylene glycol-poly (β-benzyl-L-aspartic acid) block copolymers or polyethylene glycol-poly (γ-benzyl-L-). Glutamic acid) block copolymer.

The hydrogen atom in R ⁵ in the above formula occupies 0 to 60% with respect to the entire amino acid unit, and the proportion of the group other than the hydrogen atom (represents a phenyl group, a C _{1 to} C ₈ alkyl group or a benzyl group). It needs to be in the range of 40-100%. Further, the proportion of hydrogen atoms in R ^{5 to} the whole amino acid unit is preferably 0 to 50% (the proportion of groups other than hydrogen atoms is 50 to 100%), and particularly preferably the proportion of hydrogen atoms in R ⁵ The proportion of the whole amino acid unit is 0 to 20% (the proportion of groups other than hydrogen atoms is 80 to 100%). This is because the hydrophobic interaction between the hydrophobic segment molecules for supporting the hydrophobic substance increases as the proportion of the hydrogen atom in R ⁵ occupying the whole amino acid unit decreases. This is because the substance can be more stably and highly loaded in the micelle.

  The polymer micelle of the present invention is produced by encapsulating a hydrophobic substance in a polymer micelle formed from the block copolymer. The manufacturing method is not particularly limited, and for example, it can be manufactured according to the method disclosed in JP-A-2003-26812 or JP-A-2003-342168. Specifically, a block copolymer composed of a hydrophilic segment and a hydrophobic segment and a hydrophobic substance are mixed with a volatile organic solvent such as methyl alcohol, ethyl alcohol, isopropyl alcohol, acetone, ethyl acetate, tetrahydrofuran, diethyl ether, After dissolving in cyclohexane or the like or a mixed solvent thereof, and stirring the mixture at a suitable temperature, for example, 4 ° C. to room temperature, for a sufficient time to uniformly disperse the residue obtained by removing the solvent in water, Polymer micelles with controlled particle size are produced (drying method). In addition, by mixing a water-soluble medium containing a block copolymer composed of an aqueous segment and a hydrophobic segment and a water-immiscible organic solvent containing a hydrophobic substance, the organic micelles are volatilized while stirring, so that the polymer micelle Manufactured (dispersion method). The produced polymer micelles are appropriately irradiated with ultrasonic waves from the solution obtained during the production process, and a laser diffraction scattering particle size distribution analyzer (LS Particle Size Analyzer, manufactured by BECKMAN COULTER) or a dynamic light scattering photometer. (DLS-7000DH, manufactured by Otsuka Electronics Co., Ltd.) is used to measure the particle size, and the hydrophobic substance that is not encapsulated in the micelles is removed by gel filtration.

  The particle diameter of the polymer micelle of the present invention is not particularly limited depending on the application, but specifically, the average particle diameter is in the range of 40 to 600 nm, and further, the infiltrating property to a living tissue (for example, the stratum corneum of skin). The average particle diameter is particularly preferably in the range of 40 to 200 nm, which is high and does not migrate from the living tissue to the inside of the blood vessel.

  The hydrophobic substance contained in the polymer micelle in the present invention is not particularly limited as long as the oil-water partition coefficient (LogPow) in octanol and water is 0 or more. A compound having a partition coefficient of 0 or more is defined as being fat-soluble, and conversely, a compound having a partition coefficient of 0 or less is defined as being water-soluble. In detail, any substance that is normally used as a cosmetic additive ingredient or a pharmaceutical ingredient and has an oil-water distribution coefficient of 0 or more corresponds to the hydrophobic substance used in the present invention.

  The amount of the hydrophobic substance encapsulated in the polymer micelle of the present invention is not particularly limited, but is usually adjusted in the range of 0.0001 to 20% by weight with respect to the total weight of the block copolymer, in particular, into the polymer micelle. From the viewpoint of the encapsulation efficiency of the hydrophobic substance, a range of 0.01 to 10% by weight is preferable.

In the present invention, the compound used to coexist with the polymer micelle encapsulating the hydrophobic substance is selected from glycerin, diglycerin, butylene glycol, dipropylene glycol, propylene glycol, polypropylene glycol, pentylene glycol and hexylene glycol. It is a seed or two or more kinds. These compounds are produced by known methods by chemical synthesis methods, fermentation methods or extraction methods.

  The aspect in which the polymer micelle encapsulating the hydrophobic substance and the compound coexist in the present invention is specifically achieved by adding the compound to a solution dispersed in a solvent in which the polymer micelle does not disintegrate. In addition, a method of dispersing polymer micelles in a water-soluble medium containing the compound, a method of preparing polymer micelles in the form of particles or powder, and uniformly spraying the compound on the polymer micelle, and introducing polymer micelles By applying a solution containing the compound to the target site (for example, skin) in advance by transdermal or oral administration to the target site, the polymer micelle and the compound are eventually added to the target site. For example, a method for constructing a coexisting state can be mentioned. Particularly preferred is a method in which the compound is added to a solution in which polymer micelles are dispersed, which is easy to prepare and has a wide variety of production methods and types of specific dosage forms. The solvent used for dispersion is not particularly limited as long as the polymer micelle does not disintegrate, and specific examples include water, methanol, ethanol, isopropyl alcohol, acetone, and ethyl acetate.

  The product obtained by each of the above methods is further added with a base, a cosmetic additive, or a pharmaceutical agent or additive to form a preparation such as a cosmetic, a quasi-drug, or a pharmaceutical. The formulation represents all dosage forms that can be administered orally or parenterally, specifically, capsule, powder, granule, solid, liquid, gel, foam, emulsion, cream, ointment Form, sheet form, mousse form, powder dispersion form, multilayer form, aerosol form and the like. Preferably, it is a dosage form that forms an optimal form for external application to the human skin. Examples of the external form include skin lotions, emulsions, creams, lotions, packs represented by cosmetics and quasi-drugs, Examples include soaps, body shampoos, facial cleansers, lipsticks and foundations. Moreover, ointments and patches, lotions, poultices, liniments and the like typified by pharmaceuticals and quasi drugs are listed. When forming these dosage forms, the content of the polymer micelle in the preparation is usually adjusted in the range of 0.01 to 20% with respect to the total weight of the preparation.

  When the product of the present invention is formed into a preparation such as cosmetics, quasi-drugs or pharmaceuticals, various components exemplified below can be arbitrarily selected and used as additives to further increase the functionality. It is possible to add. The content in the preparation is not particularly limited, but is usually within a concentration range of 0.0001 to 50% by weight.

Pigmentation Inhibitor A pigmentation inhibitor can be added to the product of the present invention. Specific examples of pigmentation inhibitors include p-aminobenzoic acid derivatives, salicylic acid derivatives, benzenesulfonamide derivatives, imidazole derivatives, naphthalene derivatives, hydroxyanthranilic acid or salts thereof, and derivatives thereof, anthranilic acid derivatives, coumarin derivatives, amino acids Derivatives (2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid, 2-amino-3- [1-carboxyl-2- (1H-imidazole) -4-yl) ethyl] aminobutanoic acid hydrochloride, 2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid sodium salt, 2-amino-3- [ 1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid potassium salt, etc.), benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor Derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, ascorbic acid or salts thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyprosthelic acid) Phosphorus phosphate, 5-o-α-D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L -Ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbine Acid sulfate ester calcium salt, L-ascorbate sulfate aluminum salt, L-ascorbate sodium salt, L-ascorbate potassium salt, L-ascorbate magnesium salt, L-ascorbate calcium salt, L-ascorbate aluminum salt, 6-o-α-D-galactopyranosyl-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid Phosphate sodium salt, L-ascorbic acid sulfate sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphoric acid Ester isopropanolamine salt, 3-o-isopropyl-L-ascorbic acid, 6-o-alkylascorbic acid phosphate Tellurium salt, 6-o-alkylascorbic acid phosphate calcium salt, 6-o-alkylascorbic acid phosphate barium salt, 6-o-alkylascorbic acid phosphate ammonium salt, 6-o-alkylascorbic acid Phosphate monoethanolamine salt, 6-o-alkylascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt 6-o-alkylascorbic acid phosphate diisopropanolamine salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D- Galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate cholesterol Ester, palmitic acid-L-ascorbyl, isopalmitic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid -L-ascorbyl, diisostearic acid-L-ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid- L-ascorbyl, di-2-ethylhexanoic acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L -Ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid , 2-o-α-D- Lutotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitate, L-ascorbic acid tetralaurate, L-ascorbate tetra-2-ethylhexanoate, L-ascorbate tetraoleate, 5, 6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbine Acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl cinna Pate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxyferrate, DL-α- Coferol-2-L-ascorbic acid phosphoric diester, ascorbic acid inositol binding derivative, ascorbic acid phosphoramide derivative, ascorbyl arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative, etc.), tocopherol or its Salts and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol Acetate, tocopherol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucosi DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl Glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-toco Ferryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β- Tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- ( Sulfoethylamino) -3- (α-toco Eleyl-6-Iroxy) propan-2-ol, 1- (Carboxypropylamino) -3- (α-tocopheryl-6-Iroxy) propan-2-ol hydrochloride, S- [3- (α-Toco Ferroyl-6-iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof And derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol Orotate), kojic acid or its derivatives (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoyloxymethyl-5 -Hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one, kojic acid Glucose, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate , Kojic acid dioleate, etc.), oxybenzone, benzophenone, guaiazulene, shikonin, baicalin or a salt thereof and derivatives thereof Baicalein or a salt thereof and derivatives thereof, berberine or a salt thereof and derivatives thereof, chrysin or a salt thereof and derivatives thereof, apigenin or a salt thereof and derivatives thereof, luteolin or a salt thereof and derivatives thereof, acetetine or a salt thereof and Derivatives thereof, diosmethine or a salt thereof and derivatives thereof, kaempferol or a salt thereof and derivatives thereof, triphorin or a salt thereof and derivatives thereof, astragalin or a salt thereof and derivatives thereof, quercetin or a salt thereof and derivatives thereof Quercitrin or a salt thereof and derivatives thereof, isoquercitrin or a salt thereof and derivatives thereof, rutin or a salt thereof and derivatives thereof, morin or a salt thereof and derivatives thereof, myricetin or a salt thereof And derivatives thereof, myristitrin or a salt thereof and derivatives thereof, dachiscetin or a salt thereof and derivatives thereof, quercetagetin or a salt thereof and derivatives thereof, isorhamnetin or a salt thereof and derivatives thereof, pinocembrin or a salt thereof and derivatives thereof Naringenin or a salt thereof and derivatives thereof, hesperetin or a salt thereof and derivatives thereof, eriodictyol or a salt thereof and derivatives thereof, pinobankin or a salt thereof and derivatives thereof, aromadendrin or a salt thereof and derivatives thereof, Engeritin or a salt thereof and derivatives thereof, taxofolin or a salt thereof and derivatives thereof, astilbine or a salt thereof and derivatives thereof, amperopsin or a salt thereof and derivatives thereof, Spira Oside, kaempferol-7-neohesperidoside, glutathione or salts thereof and derivatives thereof, isoflavone glycosides (6-o-apiosyl puerarin-4'-o-glucoside, 6-o-glucosyl puerarin, 3 '-Hydroxypuerarin-4'-o-glucoside,6-o-apiosyl-3'-hydroxypuerarin, etc.), γ-pyrone glycoside (maltol-3-o- (6'-o-apiosyl) -glucoside, maltol -3-o- (6′-o-apiosyl) -glucoside etc.), isononyl ferrate, ellagic acid or its salts and derivatives thereof (5,4-dimethylellagic acid, 3,3′-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-methoxyellagic acid, 3-ethyl-4-methyl-5-hydroxyellagic acid, amritoside, etc.), lucinol, Onji Saponin, Bacmond Saponin, Ruscogenin, Celicoside, Asian Chicoside Hederin, senegin, benzoic acid anilides (4-hydroxy-N- (2-hydroxyphenyl) benzoic acid amide, 4-hydroxy-N- (3-hydroxyphenyl) benzamide, 4-hydroxy-N- (4-hydroxyphenyl) ) Benzamide, 3,5-di-t-butyl-4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N- (3-hydroxyphenyl) benzamide , 3,5-di-t-butyl-4-hydroxy-N- (2-hydroxyphenyl) benzamide, etc.), diphenylpyralin, cyproheptadine, triprolysine, dimethindene, ozagrel, istipendyl, iproheptin, homochlorcyclidine, alimemazine, Bucillamine, oxytosamide, vidarabine, xanthotoxol, phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide, fetus (Bovine-derived, porcine-derived, horse-derived, sheep-derived, etc.) extract, almond extract, amaranth extract, octopus extract, lobster extract, okera extract, kofuyou extract, uncaria extract, gaija extract, kako Juyou Extract, Licorice Extract, Gardenia Extract, Kranigean Extract, Clara Extract, Koganebana (Ogon) Extract, Wheat (Wheat) Extract, Rice (Rice) Extract, Korealia Extract, Sidwaya Extract, Sunku Kyu Extract, San Vitro Extract, Sunpens extract, Silane (Biacaria) extract, Senkyu (river cucumber) extract, Senna extract, Sempukuka extract, Sentsutsusai extract, Surigatin extract, Nodake (former cucumber) extract, pearl barley (Yokuinin) extract, Vulture extract, Honey beetle , Hamamelis extract, palm extract, parietalia extract, safflower (safflower) extract, mugwa (mulberry white skin) extract, malvanojadine (bitter) extract, purple squirrel extract, white squirrel extract, mugwort extract, yashajitsu extract, hongkong Examples include an extract, a bitter melon extract, a quail extract, a citrus extract, and a millipede extract.

Tyrosinase activity inhibitor A tyrosinase activity inhibitor can be added to the product of the present invention. Specific examples of tyrosinase activity inhibitors include ascorbic acid or salts thereof and derivatives thereof (magnesium phosphate-L-ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyprophosphate phosphate ascorbate, 5-o-α -D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid Sulfate Stell aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyrano Sil-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Ester sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl- L-ascorbic acid, 6-o-alkylascorbic acid potassium ester potassium salt, 6-o-alkylascorbic acid phosphate Steal calcium salt, 6-o-alkyl ascorbic acid phosphate barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o-alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl Ascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanol Amine salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, phosphorus ascorbate Acid cholesterol ester, palmitic acid-L-ascorbyl, isopa Mycinic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid-L-ascorbyl, diisostearic acid-L- Ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid-L-ascorbyl, di-2-ethylhexane Acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α- D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-malto Triosyl-L-ascorbic acid, L-ascorbic acid Trisopalmitic acid ester, L-ascorbic acid tetralauric acid ester, L-ascorbic acid tetra-2-ethylhexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, L- Ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbyl triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl cinnamate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphoric acid diester, Scorbic acid inositol binding derivative, ascorbic acid phosphoramide derivative, ascorbic acid arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative, etc.), hydroquinone or its salts and derivatives thereof (hydroquinone α-D-glucose , Hydroquinone β-D-glucose, hydroquinone α-L-glucose, hydroquinone β-L-glucose, hydroquinone α-D-galactose, hydroquinone β-D-galactose, hydroquinone α-L-galactose, hydroquinone β-L-galactose, etc. Hexoses, hydroquinone α-D-ribose, hydroquinone β-D-ribose, hydroquinone α-L-ribose, hydroquinone β-L-ribose, hydroquinone α-D-arabinose, hydroquinone β-D-a Five carbon sugar glycosides such as rabinose, hydroquinone α-L-arabinose, hydroquinone β-L-arabinose, hydroquinone α-D-glucosamine, hydroquinone β-D-glucosamine, hydroquinone α-L-glucosamine, hydroquinone β-L- Amino sugar glycosides such as glucosamine, hydroquinone α-D-galactosamine, hydroquinone β-D-galactosamine, hydroquinone α-L-galactosamine, hydroquinone β-L-galactosamine, hydroquinone α-D-glucuronic acid, hydroquinone β-D- Glucuronic acid, hydroquinone α-L-glucuronic acid, hydroquinone β-L-glucuronic acid, hydroquinone α-D-galacturonic acid, hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, hydroquinone β-L-galacturonic acid Hydroquinone glycosides such as uronic acid glycosides Hydroquinone benzyl ether, 4-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) butane, 5-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) pentane, 6- β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) hexane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propane, 2-β-D-glucopyra Hydroquinone hydroxyalkyl ether glycosides such as nosyloxy-1- (4-hydroxyphenoxy) butane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propan-3-ol, etc.) Kojic acid or a salt thereof and derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoyloxymethyl- 5-Hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hy Droxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate , Kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.), tocopherol or a salt thereof and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate Tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ- Tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β -Tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L- α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ- Coferyl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, L- (sulfoethylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol, 1 -(Carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] Cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2 -Hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate , Tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate, etc.), N-acetyltyrosine or a salt thereof and derivatives thereof, glutathione or a salt thereof and derivatives thereof, ellagic acid or a salt thereof and derivatives thereof (3,4-dimethylellagic acid, 3,3'-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-methoxyellagic acid, 3- Ethyl-4-methyl-5-hydroxyellagic acid, amritosides, etc.), isonitrine A, isonitrine B, isonitrine C, isonitrin D, isonitrinic acid E, isonitrinic acid F, dermadein, tricobylidein and other isonitrile antibiotics, orthoric acid derivatives (Orceric acid, orceric acid ethyl ester orcinol, p-geranylorceric acid, p-gerani Orceric acid ethyl ester geranyl orcinol, p-farnesylorceric acid, p-farnesylorceric acid ethyl ester farnesylorcinol, p-dodecanylorceric acid, p-dodecanylorceric acid ethylester dodecanylorcinol, p -Tetradecanylorceric acid, p-tetradecanylorceric acid ethyl ester tetradecanylorcinol, p-hexadecanylorceric acid, p-hexadecanylorceric acid ethylester hexadecanylorcinol, p -Undecanylorceric acid, p-undecanylorceric acid ethyl ester undecanylorcinol, p-tridecanylorceric acid, p-tridecanylorceric acid ethylester undecanylorcinol, p-penta Decanylorceric acid, p-pentadecanylorserine Ethyl ester pentadecanylorcinol, ethylhexylorceric acid, p-ethylhexylorceric acid ethylester ethylhexylorcinol, p-cyclohexylmethylorceric acid, p-cyclohexylmethylorceric acid ethylester cyclohexylmethylorcinol, p-hydroxy Ethyl hexylorceric acid methyl ester, p-hydroxyethylhexylorceric acid hydroxyethylhexylorcinol, etc.), umbelic acid, brefeldin, oxydesveratrol, resorcinol derivative (4-cyclohexylresorcinol), 3-hydroxyketone compound (1, 5-bis (p-hydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (o, p-dihydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (p- Hydroxyphenyl-m-meth Ciphenyl) -2-hydroxypentan-4-one), 1,3-diketone compounds (1,5-bis (p-hydroxyphenyl) -2,4-pentanedione, 1,5-bis (o, p- Dihydroxyphenyl) -2,4-pentanedione, 1,5-bis (p-hydroxyphenyl-m-methoxyphenyl) -2,4-pentanedione, etc.), bishydroxybenzylamides, γ-aminobutyric acid or derivatives thereof (N-methyl-γ-aminobutyric acid, N-dimethyl-γ-aminobutyric acid, γ-aminobutyric acid oleyl ester, etc.), hydrogen peroxide, zinc peroxide, placenta extract, lucinol, silk extract, acacia extract, acerola extract, Ichibi (winter position) extract, Weeping birch extract, Quercus extract, Chestnut extract, Tortoise extract, Tobacco extract, Tobacco extract, Seri extract, Buckwheat extract, Davilia extract, Nazuna extract, F Zibakama (Orchid) extract, Chamomile extract, Mulberry extract, Gardenia extract, Japanese cypress extract, Walnut extract, Clara extract, Mugwort extract, Honeysuckle extract, Yellowfin extract, Dokudami extract, Matsuhodo extract, Pearl barley extract, Odorikosou extract, Hop extract, Hawthorn extract, Eucalyptus Extract, Achillea millefolium extract, Altea extract, Keihi extract, Mantis extract, Hamamelis extract, Yamaguchi extract, bellflower extract, Toshishi extract, Zyoko extract, Shoot dried extract, Mao extract, Senkyu extract, Dokatsu extract, Psycho extract, Bow extract, Hamaboufu Extract, Ogon extract, Peony skin extract, Peonies extract, Gennoshoco extract, Kudzu root extract, Licorice extract, Pyramid extract, Aloe extract, Shouma extract Safflower extract, green tea extract, black tea extract, include Uncaria gambir Roxburgh extract, and the like.

Melanocyte melanin production inhibitor A melanocyte melanin production inhibitor can be added to the product of the present invention. Specific examples of melanocyte melanin production inhibitors include lobeline or lobeline derivatives, liquiritin derivatives (such as liquiritin-α-glucoside, liquiritin-α-maltoside), phenylchroman derivatives, chromone derivatives (2-butylchromone, 2-pentylchromone, 2 -Heptylchromone, 2-nonylchromone, 2-hexadecylchromone, 2- (1-ethylpentyl) chromone, 2-butyl-7-methoxychromone, 2-pentyl-7-methoxychromone, 2-heptyl-7-methoxychromone 2-nonyl-7-methoxychromone, 2-pentadecyl-7-methoxychromone, 2- (1-ethylpentyl) -7-methoxychromone, 7-hydroxy-2-methylchromone, 7-hydroxy-2-butylchromone 7-hydroxy-2-pentylchromone, 7-hydroxy-2-heptylchromone, 7-hydroxy-2-nonylchromone, 7-hydroxy-2-penta Desylchromone, 7-hydroxy-2- (1-ethylpentyl) chromone), azelaic acid derivatives (azelaic acid monoalkyl ester, azelaic acid dialkyl ester, etc.), phosphatidylglucosamine, lysophosphatidylglucosamine, phenylhydroquinone, 3-β-D -Glucopyranosyl manur, 3-β-D-maltopyranosyl manur, substituted amino acid derivatives (DL-N-formyl-3- (1-naphthyl) alanine, DL-N-acetyl-3- (1-naphthyl) ) Alanine, DL-N-propionyl-3- (1-naphthyl) alanine, DL-N-butyryl-3- (1-naphthyl) alanine, DL-N-isobutyryl-3- (1-naphthyl) alanine, DL- N-valeryl-3- (1-naphthyl) alanine, DL-N-isovaleryl-3- (1-naphthyl) alanine, DL-N- (2-methylvaleryl) -3- (1-naphthyl) alanine, DL-N -(3-Methylvaleryl) -3- (1-naphthyl) alanine, DL-N- (4-Methylvaleryl) -3- (1 -Naphthyl) alanine, DL-N-t-butylacetyl-3- (1-naphthyl) alanine, DL-N-pivaloyl-3- (1-naphthyl) alanine, DL-N-caproyl-3- (1-naphthyl) ) Alanine, DL-N- (2-ethylhexanoyl) -3- (1-naphthyl) alanine, DL-N- (2-methylhexanoyl) -3- (1-naphthyl) alanine, DL-N-heptanoyl -3- (1-naphthyl) alanine, DL-N-octanoyl-3- (1-naphthyl) alanine, DL-N- (2-propylpentanoyl) -3- (1-naphthyl) alanine, DL-N- Nonanoyl-3- (1-naphthyl) alanine, DL-N-decanoyl-3- (1-naphthyl) alanine, DL-N-undecanoyl-3- (1-naphthyl) alanine, DL-N-dodecanoyl-3- ( 1-naphthyl) alanine, DL-N-tridecanoyl-3- (1-naphthyl) alanine, DL-N-tetradecanoyl-3- (1-naphthyl) alanine, DL-N-pentadecanoyl-3- (1 -Naphthyl) alanine, DL-N-hexadecanoyl-3- (1-naphthyl) alanine DL-N-heptadecanoyl-3- (1-naphthyl) alanine, DL-N-octadecanoyl-3- (1-naphthyl) alanine, DL-N-nonadecanoyl-DL-3- (1-naphthyl) alanine, DL -N-icosanoyl-3- (1-naphthyl) alanine, DL-N-acryloyl-3- (1-naphthyl) alanine, DL-N-crotoniloyl-3- (1-naphthyl) alanine, DL-N-methacryloyl- 3- (1-naphthyl) alanine, DL-N-vinylacetyl-3- (1-naphthyl) alanine, DL-N-cyclopropanoyl-3- (1-naphthyl) alanine, DL-N- (2-pentenoyl ) -3- (1-naphthyl) alanine, DL-N- (4-pentenoyl) -3- (1-naphthyl) alanine, DL-N- (2-hexenoyl) -3- (1-naphthyl) alanine, DL -N- (3-hexenoyl) -3- (1-naphthyl) alanine, DL-N- (2-methyl-3-pentenoyl) -3- (1-naphthyl) alanine, DL-N-cyclohexenoyl -3- (1-naphthyl) alanine, DL-N- (10-undecenoyl) -3- (1-naphthyl) alanine, D LN-linoleyl-3- (1-naphthyl) alanine, DL-N-hydroxyacetyl-3- (1-naphthyl) alanine, DL-N- (6-hydroxycaproyl) -3- (1-naphthyl) alanine, DL-N- (8-hydroxyoctanoyl) -3- (1-naphthyl) alanine, DL-N- (9-hydroxynonanoyl) -3- (1-naphthyl) alanine, DL-N- (10-hydroxy Decanoyl) -3- (1-naphthyl) alanine, DL-N- (11-hydroxyundecanoyl) -3- (1-naphthyl) alanine, DL-N- (12-hydroxydecanoyl) -3- ( 1-naphthyl) alanine, DL-N-benzoyl-3- (1-naphthyl) alanine, DL-N- (2-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-hydroxybenzoyl ) -3- (1-naphthyl) alanine, DL-N- (4-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (o-toluyl) -3- (1-naphthyl) alanine, DL-N- (m-Toluyl) -3- (1-naphthyl) alanine, DL-N- (p-Toluyl) -3- (1-naphthyl) ara DL-N- (1-naphthyl) -3- (1-naphthyl) alanine, DL-N- (2-naphthyl) -3- (1-naphthyl) alanine, DL-N- (2-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (4-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (2-picoline) -3- (1-naphthyl) alanine, DL-N- (3-picoline) -3- (1-naphthyl) alanine, DL-N- (4-picoline) -3- (1-naphthyl) alanine, DL-N-phenylacetyl-3- (1-naphthyl) alanine, DL-N- (2-phenylpropanoyl) -3- (1-naphthyl) alanine, DL-N- (3 -Phenylbutyryl) -3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine, DL-N-valeryl-3- (1-naphthyl) alanine, DL -N- (4-methylvaleryl) -3- (1-naphthyl) alaninamide, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine methyl ester DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine ethyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine propyl ester, DL-N- (4-methylvaleryl ) -3- (1-naphthyl) alanine-N-butyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine pentyl ester, DL-N- (4-methylvaleryl) -3- ( 1-naphthyl) alanine isopropyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine isobutyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine-t- Butyl ester, etc.), benzolactam derivatives, indolactam derivatives, cedrol, guaiool, 1- (4-hydroxyphenthio) -2-propanol, β-lactoglobulin, 2-methoxy-5-methylphenol, 5-ethyl-2 -Methoxyphenol, 5-N-propyl-2-methoxyphenol, 5-N-butyl-2-methoxypheno 5-N-hexyl-2-methoxyphenol, 5-N-heptyl-2-methoxyphenol, 5-N-decyl-2-methoxyphenol, 5- (1,1-dimethylpropyl) -2-methoxy Phenol, 5- (1,1-dimethylbutyl) -2-methoxyphenol, 5- (1,1-dimethylethyl) -2-methoxyphenol, 2-methoxy-5- (1-methylpentyl) phenol, 2- Methoxy-5- (1-methylhexyl) phenol, 2-methoxy-5- (3-methylhexyl) phenol, 2-methoxy-5- (6-methylheptyl) phenol, 5- (1,3-dimethylheptyl) -2-Methoxyphenol, malvelin, ferguinol, sugiol, cryptojaponol, 1,5-bis [p-hydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [o-hydroxyphenyl]- 1,4-pentadien-3-one, 1,5-bis [2,4-dihydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [3-mes Xyl-4-hydroxyphenyl] -1,4-pentadien-3-one, haginin, agrimophor, agrimol, hydrangenol or derivatives thereof, alkylresorcinol or derivatives thereof (such as 4-N-butylresorcinol), aristrone, Caramenenes (such as caramenene, 7-hydroxycaramenene, 5-hydroxycaramenene, 7-methoxycaramenene), trans-umberic acid, N-α-benzoyl-L-arginine, N-α-benzoyl-L-arginine ethyl Ester or N-α-benzoyl-L-arginine ethyl ester, 5-methyl-2 (3H) -furanone, 2-butene-4-olide, 2-hydroxymethylfuran, 2,5-dimethyl-4-hydroxy-3 (2H) -furanone, 2-formylfuran, 3-formylfuran, methyl α-furyl ketone, furfuryl acetate, 2-hydroxy-3-methyl-2-cyclopenten-1-one, 2-hydroxy-3,5 -Dimethyl-2-cyclopenten-1-one, 2,5-dimethyl-4-hydroxy-3 (2H) -thiophenone, 2-hydroxy-3-ethyl-2-cyclopenten-1-one, tetronic acid, pentanedione, Iminodibenzyls (2,2'-iminodibenzyl, imipramine, imipramine hydrochloride, desipramine, desipramine hydrochloride, chlorimipramine, trimipramine, etc.), dibenzocycloheptadienes (amitriptyline, amitriptyline hydrochloride, nortriptyline, noxiptylline, etc.), Tetrahydrocopalol glycosides (ketotifen fumarate, labda-8 (17), 13-dien-15-ol, tetrahydromanur, tetrahydrocoparol, tetrahydrocoparol glucoside, tetrahydrocoparol galactoside, tetrahydrocoparol maltoside, Tetrahydrocoparol cellobioside, Tet Lahydrocopalol maltotrioside, etc.), spiro ether compound, piochelin, phenothiazine compound, promethazine, alimemazine, alimemazine tartrate, triflupromazine, levomepromazine, chlorpromazine, cyclandrate, 4-carboxymethyloxybenzoic acid, 4-carboxymethyl Oxy-2-hydroxybenzoic acid, 3- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) benzoic acid, 4- (3-carboxypropyl- 1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-methoxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4 -(5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1 -Oxy) -2-hydroxybenzoic acid, 4- (10-carbamoyldecane-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) benzoic acid, 4- (4-hydroxy Butyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-acetoxybutyl-1-oxy) benzoic acid, 4- (4-acetoxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- ( 3-Ethoxycarbonylpropyl-1-oxy) -2-hydroxybenzoic acid, 3- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-methoxybutyl-1-oxy) 2-hydroxybenzoic acid, 4- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3- (3-carboxypropyl-1- Oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxy Benzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1 -Oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid, hydroxytrimethylcyclohexanes (2-hydroxy-4- (2,2,6-trimethyl-1) -Yl-cyclohexane) butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -1-butene, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2-butene 4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 3-methyl-3-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl -1-Hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl -1-Hydro Ci-5- (2,2,6-trimethyl-1-yl-cyclohexane) -3-pentene, 3-methyl-3-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane)- 1-pentene, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -2-pentene, 2-hydroxy-4- (2,2,6-trimethyl-1 -Mono-, di- or trisaccharide glycosides such as -yl-cyclohexane) butane), escinol, parahydroxycinnamic acid-4- (2,2,6-trimethyl-yl-cyclohexane) -2-butyl ester Monosaccharide, disaccharide or trisaccharide glycoside, ondisaponin, bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin, senegin, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2 -Keto-butane, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto-butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2 -Keto-3-butene, 4- (2,2 , 6-Trimethyl-1-yl-6-cyclohexene) -2-keto-3-butene (β-ionone), Lp-hydroxyphenylglycine, Dp-hydroxyphenylglycine, N-benzyloxycarbonyl-Lp-hydroxyphenylglycine N-benzyloxycarbonyl-Dp-hydroxyphenylglycine, N-benzoyl-Lp-hydroxyphenylglycine, N-benzoyl-Dp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Dp-hydroxyphenylglycine, N- (p-hydroxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-hydroxybenzoyl) -Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxy Phenylglycine, N-acetyl-Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine ethyl ester, N-acetyl-Dp-hydroxyphenylglycine ethyl ester, N-acetyl-Lp-hydroxyphenylglycinamide, N-acetyl-Dp-hydroxyphenylglycinamide, Lp-methoxyphenylglycine, Dp-methoxyphenylglycine, Lp-methoxyphenyl Glycine hydrochloride, Dp-methoxyphenyl glycine hydrochloride, 4-hydroxy-3-methoxy-L-phenylglycine, 4-hydroxy-3-methoxy-D-phenylglycine, Lp-hydroxyphenylglycine ethylamide, Dp-hydroxyphenyl Glycine ethylamide, N-tert-butoxycarbonyl-Lp-hydroxyphenylglycine, N-tert-butoxycarbonyl-Dp-hydroxyphenylglycine, N-tert-butoxycarbonyl-Lp-methoxyphenylglycine, N-tert-butoxycarbonyl- Dp-methoxyphenylglycine, N-9-fluorenylmethyl Oxycarbonyl-Lp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxyphenylglycine benzyl ester hydrochloride, N-9 -Fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine benzyl ester hydrochloride, Lp-hydroxyphenylglycinamide, Dp-hydroxyphenylglycinamide, Lp-hydroxyphenylglycine allyl ester p-toluenesulfonate, Dp-hydroxyphenyl Glycine allyl ester p-toluenesulfonate, Lp-hydroxyphenylglycine benzyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine benzyl ester p-toluenesulfonate, Lp-hydroxyphenylglycine ethyl ester 1,3-diallyl, such as Dp-hydroxyphenylglycine ethyl ester, Lp-hydroxyphenylglycine ethyl ester hydrochloride, Dp-hydroxyphenylglycine ethyl ester hydrochloride, Lp-hydroxyphenylglycine methyl ester, Dp-hydroxyphenylglycine methyl ester Indan-2-carboxylic acids, stachybosines, pheophorbide derivatives, eleucerin, isoeleucerine or 4-β-hydroxyisoereucerin, eleucerinol, spiroketal derivatives (2- (2,4-hexadiniylidene) -1,6-dioxaspiro [4.5] Dec-3-ene, 2- (2-hexynylidene) -1,6-dioxaspiro [4.4] Nona-3-ene, 2-((4-methylphenyl) methylidene) -6,6-dioxaspiro [4.4 ] Nona-3-ene, 2- (2-hexenylidene) -6,6-dioxaspiro [4.5] dec-3-ene, 2- (2-hexenylidene) -1,6-dioxaspir [4.4] Non-3-ene, 2-hexyl-1,6-dioxaspiro [4.4] nonane, 2- (2-hexenyl) -1,6-dioxaspiro [4.4] nonane, 2- (2-hexynyl) -1 , 6-Dioxaspiro [4.4] nonane, 2-pentyl-1,6-dioxaspiro [4.4] nonane, 1,6-dioxaspiro [4.4] nonane, 1,6-dioxaspiro [4.5] decane, 1,7-dioxaspiro [5.5 ] Undecane, 2,3-benzo-4,4-dimethyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-pentyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo -2-hexyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-octyl-1,6-dioxaspiro [4.4] nonane, 2-hexyl-9,9-dimethyl-1,6-dioxaspiro [4.4] Nonane, 2- (2,4-hexadiynylidene) -1,6-dioxaspiro [4.4] non-3-ene, etc.), malvalic acid, phosphonic acid derivative or salt thereof, aspergillomarasmine, aminophosphone Acid derivatives or salts thereof, di Phenhydramine or salt thereof, pregnenolone or derivative thereof, lutein, farnesyl isopropanol derivative, hexahydrofarnesyl acetone, 4-benzoylamino-2-hydroxybenzoic acid, 5-benzoylamino-2-hydroxybenzoic acid, 4-benzoylaminobenzoic acid Acid, 4- (1-naphthoylamino) -2-hydroxybenzoic acid, 5- (1-naphthoylamino) -2-hydroxybenzoic acid, 4- (2-naphthoylamino) -2-hydroxybenzoic acid, 5- (2-naphthoylamino) -2-hydroxybenzoic acid, 4- (1-naphthoylamino) benzoic acid, 4- (2-naphthoylamino) benzoic acid, 4-phenylaminocarbonylbenzoic acid, 4- Phenylaminocarbonyl-2-hydroxybenzoic acid, 5-phenylaminocarbonyl-2-hydroxybenzoic acid, 4- (1-naphthylaminocarbonyl) benzoic acid, 4- (1-naphthylaminocarbonyl) ) -2-hydroxybenzoic acid, 5- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 4- (2-naphthylaminocarbonyl) benzoic acid, 4- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid Acid, 5- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, hexahydrofarnesyl isopropanol derivative, borneol-p-hydroxycinnamate glucoside, borneol-p-hydroxycinnamate maltoside, borneol-p -Hydroxycinnamic ester maltotrioside, cinnamic acid-4- (2,2,6-trimethyl-yl-cyclohexane) -2-butyl ester derivative, 2,4-dihydroxybenzophenone, 1- (2,4-dihydroxy Phenyl) -ethanone (2 ′, 4′-dihydroxyacetophenone), 1- (2,4-dihydroxyphenyl) -1-propanone (2 ′, 4′-dihydroxypropiophenone), 1- (2,4-dihydroxy) (Droxyphenyl) -1-butanone, 1- (2,4-dihydroxyphenyl) -1-pentanone, 1- (2,4-dihydroxyphenyl) -1-hexanone, 1- (2,4-dihydroxyphenyl)- 1-heptanone, 1- (2,4-dihydroxyphenyl) -1-octanone, 1- (2,4-dihydroxyphenyl) -1-nonanone, 1- (2,4-dihydroxyphenyl) -1-decanone, 1 -(2,4-dihydroxyphenyl) -1-undecanone, 1- (2,4-dihydroxyphenyl) -1-dodecanone, 1- (2,4-dihydroxyphenyl) -1-tetradecanone, 1- (2,4 -Dihydroxyphenyl) -1-hexadecanone, 1- (2,4-dihydroxyphenyl) -1-octadecanone, 1- (2-hydroxy-4-methoxyphenyl) -ethanone (2'-hydroxy-4'-methoxyacetophenone) 1- (2-hydroxy-4-methoxyphenyl) -1-propanone (2′-hydroxy-4′-methoxypropiophenone), 1- (2-hydroxy-4-methoxyphenone) L) -1-butanone, 1- (2-hydroxy-4-methoxyphenyl) -1-pentanone, 1- (2-hydroxy-4-methoxyphenyl) -1-hexanone, 1- (2-hydroxy-4- Methoxyphenyl) -1-heptanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octanone, 1- (2-hydroxy-4-methoxyphenyl) -1-nonanone, 1- (2-hydroxy-4 -Methoxyphenyl) -1-decanone, 1- (2-hydroxy-4-methoxyphenyl) -1-undecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-dodecanone, 1- (2-hydroxy- 4-methoxyphenyl) -1-tetradecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-hexadecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octadecanone, 1- (4-hydroxy -2-methoxyphenyl) -ethanone (4'-hydroxy-2'-methoxyacetophenone), 1- (4-hydroxy-2-methoxyphenyl) -1-propanone (4'-hydro Cis-2′-methoxypropiophenone), 1- (2,4-dimethoxyphenyl) -ethanone (2 ′, 4′-dimethoxyacetophenone), 1- (2,4-dimethoxyphenyl) -1-propanone (2 ', 4'-dimethoxypropiophenone), lactone derivatives (1,6-dioxaspiro [4.4] nonane-2,7-dione, 1,6-dioxaspiro [4.5] decane-2,7-dione, 4-tridecanolide, 4-dodecanolide, 4-undecanolide, 4-decanolide, 4-nonanolide, 4-octanolide, 4-heptanolide, 5-dodecanolide, 5-undecanolide, 5-decanolide, 5-nonanolide, 5-octanolide, 2-undecen-4- Orido, 2-Decene-4-Olide, 2-Nonene-4-Olide, 2-Heptene-4-Olide, 2-Undecen-5-Olide, 2-Decene-5-Olide, 2-Nonene-5-Olide, 2-octene-5-olide, 4-methyl-4-dodecanolide, 4-methyl-4-undecanolide, 4-methyl-4-decanolide, 4-methyl-4- Nanolide, 4-methyl-4-heptanolide, 5-methyl-5-dodecanolide, 5-methyl-5-undecanolide, 5-methyl-5-decanolide, 5-methyl-5-nonanolide, 5-methyl-5-octanolide, 2-methoxycarbonyl-4-dodecanolide, 2-methoxycarbonyl-4-undecanolide, 2-methoxycarbonyl-4-decanolide, 2-methoxycarbonyl-4-nonanolide, 2-methoxycarbonyl-4-heptanolide, 2-methoxycarbonyl- 5-undecanolide, 2-methoxycarbonyl-5-decanolide, 2-methoxycarbonyl-5-nonanolide, 2-methoxycarbonyl-5-octanolide, 2-allyl-4-undecanolide, 2-allyl-5-decanolide, 2-allyl -4-nonanolide, 2-pentyl-4-undecanolide, 2-pentyl-4-nonanolide, 2-methyl-4-undecanolide, 2-methyl-4-nonanolide, 2- (4-hydroxybutyl) -4-undecanolide, 2 -(4-hydroxybutyl) -4-nonanolide, 2- (4-hydroxybutyl) -5-decanolide, 5-propyloxy-4-pentanolide, 5-allyloxy-4-pentanolide, 5- (2-hydroxyethoxy) -4-pentanolide, 8-hydroxy-4-octanolide, 6-propyloxy-5-hexanolide, 6-allyloxy-5-hexanolide, 6- (2-hydroxyethoxy) -5-hexanolide, 9-hydroxy-5-nonanolide Ethinomycin, iriflorental, iriparidal, 2'-8-C-glucosyl-7-methyl aloesol coumaroyl ester, 2'-8-C-glucosyl-7-methyl aloesol cinnamoyl ester, chloropyramine, Anise extract, Aloe extract, Japanese knotweed extract, Onibasiri extract, Ebisu rush extract, Ketsumeishi (Keiko) extract, Ogi (yellow cocoon) extract, Eurasian eagle extract, Okarasuuri ( Locon) extract, Onamomi (Cirrus ear) extract, Oni yagara (Tempa) extract, Oyster extract, Ginseng extract, Uyaku extract, Pumpkin extract, Gama (Yellow yellow) extract, Kansui extract, Ginseng (Sengakusa) extract, Black-skinned extract, Black-spotted extract, Sisal (Sisal Asa) extract, Saximara kojiru extract, Sinabot kuzuru extract, Sinasenninsou (wei Sensen) extract, Oshima cherry extract, Oya cherry extract, Bean cherry extract, Takane cherry extract, Kohigan extract, Sato cherry extract, Zion extract, palm extract, white vanilla extract, ginseng extract, red pepper extract, diamondfish extract, camellia extract, toshishi extract, bean extract, prunus extract, sagebrush , Yarrow Extract, Hacksen Extract, Dill Extract, Honey Beetle Extract, Snail Extract, Hitotsuba Extract, Himabitan Extract Extract, sandalwood extract, garlic mushroom (reishi) extract, swordfish (beneficial herb) extract, river willow extract, red willow extract, cat willow extract, dog collage willow extract, quince willow extract, cory willow extract, unryu willow extract, yama willow extract, wild willow extract Willow extract, Chinese cabbage willow extract, Fox willow extract, Dronoki extract, Japanese yam extract, Agave extract, Aonu agave extract, Fukurin Agave extract Kiss, Mitsumata Extract, Aonori Extract, Usubaaonori Extract, Susiaoonori Extract, Hiiraaoori Extract, Bowuaonori Extract, Hosoe Aonori Extract, Kombu Extract, Maconbu Extract, Resilicon Extract, Hosomikombu Extract, Mitsuishi Kombu Extract, Wakame Extract, Hiromeaoka Extracts Giraffe rhinoceros extract, juniper ginger rhinoceros extract, tsunomata extract, ibottsu no mata extract, malvatsu nomata extract, hirakotoji extract, cedar Re-extract, Shikinori extract, Kainori extract, Yakuzusa extract, Urabo shiyahaz extract, Umiuchiwa extract, Ishimozuku extract, Misjikonbu extract, Atsubamisjikonbu extract, Isamomoku extract, Nagashimamok extract, Shidamamok extract, Nashimoku extract, Narasamo extract, Tatsuma extract Yatsumata Moku Extract, Umitorano Extract, Oba Moku Extract, Fussi Moku Extract, Haha Moku Extract, Yoremo Moku Extract, Saw Maw Moku Extract, Psyllium Moku Extract, Mukadenori Extract, Nuraxa Extract, Cronouraxa Extract, Oomka Denori Extract, Matsunori Extract, Oo Sponge Extract, Fushitsugi Extract, Himefutsutsugi Extract, Hirohafutsutsugi Extract, Kurosozo Extract, Kobosozoe Vinegar, Hanesozoekisu, Sozonohanaekisu, brush Saki sawtooth Hiba extract, Thira extract, duck over Tede bruises franc extract, Hamaikaekisu, port Leo Verde extract, Nabo Negro extract, Schisandra chinensis extract, Matsubusa extract, Binankazura extract, and the like.

Melanin production promoter A melanin production promoter can be added to the product of the present invention. Specific examples of the melanin production accelerator include salicylic acid or a salt thereof and derivatives thereof (salicylic acid glucoside, salicylic acid fatty acid ester, salicylic acid alcohol ether, salicylic acid amides, etc.), salicyl alcohol or a salt thereof and derivatives thereof, apigenin, and amentoflavone. , Salamander extract, Udo extract, Shishido extract, Nirinso extract, Oak extract, Beef Taxi extract, Cuckoo thistle extract, Gypsophila extract, Gymnema sylvestre extract, Carrion extract, Ginkgo biloba extract, Konronka extract, Sabinryo extract, Jasmine (pine licorice) extract, hollyhock extract, scallop extract, Arabidopsis extract, lily of the valley extract, sow extract, deco extract, eucommia extract, nagii Da (Butcher Bloom) Extract, Teppouri Extract, Tokiwa Mansaku Extract, Nankin Gouze Extract, Elderberry Extract, Nadesico Extract, Mite Willow Extract, Sardine Willow Extract, Morohaya Extract Zakifujime extract, Ryokakou extract, Ajigusa extract, shellfish extract (cockle extract, green mussel extract, oyster extract, European oyster extract, scallop extract, clam extract, clam extract, bakagai extract, ishi mussel extract, red mussel extract, abalone extract, Sazae extract, bi-extract, etc.).

Humectant A humectant can be added to the product of the present invention. Specific examples of moisturizers include gum arabic, benzoin rubber, danmar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum, carob gum, quince seed, agar or its derivatives, casein, glucose, galactose, mannose, xylose, fructose, maltose, iso Maltose, cellobiose, gentiobiose, trehalose, cordierbiose, laminaribiose, nigerose, sambubiose, neohesperidose, apiose, hammamellose, streptose, hydroxystreptose, dihydrostreptose, 2-methylerythrose or derivatives thereof, 2-methylerythrono Lactone, micalose, cladinose, accessose, alkanose, olivomai course, chromose, ebamise, vinerose , Sugars such as nogarose, bilenose, nobiose, moenuronic acid, galosamine, cybirosamine, N-acylcansosamine, vancosamine, evanitrose, rubranitrose, tetronitrose, pyralose, α-octose, trioxacalcinose, aldgarose, blastminosin 1,3-butylene glycol, glycerin, propylene glycol, polyethylene glycol, dipropylene glycol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,6-hexanediol, mannitol and Sorbitol, ethanediol, diethylene glycol, triethylene glycol, 2-amino-2-methyl-1,3-propanediol, 1,2-propanediol, 1,3-propanediol, polypropylene glycol, 1,2-butyl Diol, 1,3-butanediol, 1,4-butanediol, isopentanediol, pentylene glycol, hexylene glycol, 1,3-pentanediol, 1,4-pentanediol, 1,2,3-pentanetriol, 2,3,4-pentanetriol, 1,3,4-pentanetriol, 1,3,5-pentanetriol, 1,3-hexanediol, 1,4-hexanediol, 1,5-hexanediol, 1, 2,3-hexanetriol, 1,3,4-hexanetriol, 1,3,5-hexanetriol, 1,4,6-hexanetriol, erythritol, pentaerythritol, dipentaerythritol, threitol, arabitol, xylitol, Ribitol, galactitol, lactitol, maltitol, inositol, panthenol, laminitol, valienamine, validamine, validatitol, trehalose Is a derivative thereof, D-mannosamine and derivatives thereof, isomaltoligosaccharide (panose), primeverose or derivatives thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, alkylene (C2-C4) oxide such as ethylene oxide Is added hydroxyalkyl (C2-C4) chitin or chitosan, low molecular chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or Its salt, β-1,3-glucan, β-1,4-glucan, β-1,6-glucan, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose, carboxyethylcellulose, sodium carboxyethylcellulose, hydroxy Polyalkylene oxides such as chill cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, hydroxypropyl methylcellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyethylene oxide and polypropylene oxide or cross-linking polymerization thereof. Water-soluble polymers such as carboxyvinyl polymer, polyethyleneimine, dermatan sulfate, keratan sulfate, glycerin fatty acid pyrrolidone carboxylic acid ester, glycerin fatty acid acetyl amino acid ester, pyrrolidone carboxylic acid or salt thereof, polyaspartic acid or salt thereof , Polyglutamic acid or its salt, polylysine or its salt, sodium lactate, hydantoin and its derivatives Np-vinylbenzyl-D-cellobionamide, Np-vinylbenzyl-D-lactone amide, Np-vinylbenzyl-D-maltonamide, Np-vinylbenzyl-D-gluconamide, glucosyloxyethyl methacrylate, galactosyloxy Propyl acrylate, mannosyloxyethyl methacrylate, glutamyl lysine, glutaurine, 1,2,4-butanetriol, caran-3,4-diol, azoxaponin (3-o- [β-D-glucopyranosyl-β-D-glucurono Pyranosyl] -sophoradiol, 3-o- [β-D-glucopyranosyl-3-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D- Glucuronopyranosyl] -azuxapogenol, 3-o- [β-D-glucopyranosyl] -28-o- [β-D-glucopyranosyl-β-D-glucopyranosyl] -dipsogenic acid, 3-o- [ α-L-rhamnopyranosyl-β-D-glucopyra Sil-β-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -29-o- [β-D- Glucopyranosyl-β-D-glucopyranosyl] -azuxapogenol , Malva morning glory extract, morning glory extract, Athira (shokuyo kanna) extract, oilseed rape extract, amachazul extract, amana extract Ito extract, Hosoa Otome extract, Aogateto extract, Haribiyu extract, Aozulan extract, Amaranthus hippocondri Cus extract, Aristolomeria (Yurizuisen) extract, Arcana (alcanna) extract, Argarobo (cabbe) extract, Aloe vera extract, rush (1) , Dog mint extract, sardine tobacco (Iwabuchi) extract, iwahiba extract, sardine pine (roll mushroom) extract, wheat (chibusanoki) extract, duckweed (float) extract, euglena thrips extract, euglena extract, unyadegato (uncaria) extract, enokitake (榎 茸) extract, eringi extract, pre-lotus eringi extract, ogatahouken extract, oguruma (civil engineering incense) extract, euglena (cereal essence) extract, oka extract, okazeli (serpentine) extract, okra extract, onidokoro extract, Tokoroe Kiss, Nagadokoro (Hikai) extract, Ononis extract, Yuuko extract, Oyster extract, Ginseng extract, Gaku hydrangea extract, Cascara sagrada extract, Gypsophila extract, Panax ginseng extract, Kaniwa extract, Carnation extract, Gerbera extract, Camcam (camo duck) ) Extract, Color extract, Oat extract, Karin (Kiso) extract, Kawara Psycho (compulsed rape, tranquilized white grass) extract, Kawajisha extract, Kawaranadeshiko (stone bamboo) extract, Ezokawaranadeko (Soba, buckwheat) extract, Kantarasaasa extract, Kikutaniku extract, quinoa extract, cabbage extract, kiwi extract, cucumber extract, gyory (Nishikawa willow, teyanagi) extract, Kirangsou (golden grass weed) extract, guayule extract, Kusagisuzuki (Tenmon winter) extract, kudzu ) Extract, ginseng (yellow flower bud) extract, cupuas extract, gumbai tuna (Sekimei, Sekimeishi) extract, Kemponashi (Kigushi) extract, gekkavidin (Beautiful under the moon) extract, Kouren (Huo Ren) extract, coconut extract, cosmos extract, co Button leopard extract, rice oil extract, konjac extract, saffron (banban flower, west red flower) extract, sapodilla extract, sangre degrad (croton) extract, sanchinin ginseng (37 ginseng) extract, shea (carite) extract, cyanoki extract, shiitake mushroom extract Shiitake extract, shimeji mushroom extract, hin-shimeji mushroom extract, shaka shimeji mushroom extract, hatake shimeji mushroom extract, oshiroi shimeji mushroom extract, beech shimeji mushroom extract, honji mushi extract, shirotamogitake extract, shimokren extract , Ryukyu Kasamisou Extract, Ryukyu Hydrangea (Tsunayama) Extract, White Rooster Butterfly Extract, White Clover (Chicken Bones) Extract, Ginkgo biloba (Mizuka, Ryoka Flower, Shencho Flower) Extract, Watermelon (Sairan) Extract, Suzu-Psycho (Xulongan) Extract, Surihiyu (Horse Soap, Horse Teeth) Extract, Sekkoku Extract, Sakura Sekkoku Extract, Koki Sekkoku Extract, Obanase Sekkok Extract, Okinawa Sekkok Extract, Hon Sekkokoku Extract, Shika Sekkokoku Extract, Kiba Nano Sekkok Extract, Cedron (Boushuboku) extract, mallow extract, celery extract, senshinren (baffled ream) extract, Japanese radish (radish) extract, Takasaburo (Boku lotus) extract, Tachidokoro (hikai) extract, dahlia (tenjiku button) extract, tarwi extract, sen Kinshi extract, soju Tulip extract, Chanca Piedra extract, Tulip extract, Chorogi extract, Tsukuritake mushroom extract, camellia extract, camellia extract, Tounabena extract, corn extract, corn hair , Toxa (wood bandits) extract, ash (crustacean) extract, turkey falcon extract, peanut extract, vertical blade (sword bean) extract, jujube (large cocoon) extract, navena (continuous) extract, nameco extract, namban ramie (cannabis) extract , Niois violet extract, nutmeg extract, Nemum extract, Nebu extract, Nebi extract, Nemkinoki extract, Digokubana extract Extracts Extract, bell pepper extract, Japanese apricot extract, Japanese pine bamboo (Kawariharatake, Hiromatsutake) extract, eucheuma (Coleoptera) extract, Brazilian licorice extract, hazelnut extract, loofah extract, red-breasted extract, Ikusa (jingten) extract, Bakigi extract, Chrysanthemum extract, Nendodon extract, Hahagigi Kokia (geum coconut) extract, spinach (Akansen, Acute pupa, Periosteum) extract, Diptera edulis extract, Hosobakirinso (Keiten zosan) extract, Jojoba Kiss, Borage extract, Bordeaux extract, Hononiku (meat juju, Taigei) extract, Honsekkok (iron skin stone, Sparrow mountain stone) extract, Maca extract, Macadamia nut extract, Margaret (Mokushungiku) extract, Tamanozen Hallen Extract, kyukonkinrenka extract, matatabi (wooden cocoon) extract, pine coconut extract, matsuhodo (cocoon) extract, matico (cordon sillo) extract, quince extract, malein (biloudomozuika) extract, manzanya (andesukamitsuru) extract, mizusobako extract , Japanese morning glory extract, green mint extract, wheat straw extract, munya extract, purple extract, purple purple extract, purple jelly extract, moge extract, mochinoki extract, Yag Masowa extract, Yacon extract, Palm extract, Yabu tobacco (Tsurugai, Tenmeisei) extract, Maronnier extract, Mokka extract, Lily extract, Raigan (Raimaru) extract, Lime extract, Rye extract, Rakkyou extract, Shallot (palm white) extract, Apple extract , Gentian extract, litchi (piper, toothpick) extract, lotus extract, yokuinin extract, minisasaniki extract, chlorella vulgaris extract, chlorella pyrenoid extract, chlorella ellipsoidia extract, macrocystis pirifera extract, euquiri extract , Tosakanori extract, Cyprinus extract, Amakusa Nori extract, Aoimidro extract, Kawanoori extract, Marimo extract, Mochikihitoe extract, Ezoyahaz extract, Habanori extract, Atlantic havanori extract, Cottontail extract, A Extract, squirrel extract, trolley extract, antokume extract, pickled alley extract, black squirrel extract, cat corn extract, Ainu turtle extract, chigaiso extract, squirrel extract, yabanemoku extract, trumpet extract, uganomoku extract, joromoku extract, hyamok extract, tamanashi moku extract, Honda Walla Extract, Sugi Moku Extract, Bovine Kenori Extract, Susabi Nori Extract, Akebono Mozuku Extract, Sea Elephant Swine Extract, Fusanori Extract, Hoso Banamino Hana Extract, Hanaf nori Extract, Itohnori Extract, Kaginori Extract, Mirin Extract, Hoso Bamirin Extract, Chrysanthemum Extract, Ezonameshi Extract Ibaranori Extract, Kaigai Baranori Extract, Saidaibara Extract, Tachiibara Extract, Ogonori Extract, Tsurushiramoeki , Bee Zhou Gelidium nilotica extract, Okitsunori extract, Aqaba ginkgo Saw extract, natto culture metabolites, natto extract, sponge gourd water, birch (birch) or Akamatsu sap, and the like.

Cell Activator / Metabolic Activator A cell activator / metabolic activator can be added to the product of the present invention. Specific examples of cell activators and metabolic activators include vitamin A group: retinol or its salts and derivatives thereof (retinyl unsaturated fatty acid esters such as retinyl linoleate, retinyl linolenate, retinyl oleate, retinyl arachidate, etc.) ), Retinal or a salt thereof and derivatives thereof, dehydroretinal or a salt thereof and derivatives thereof, retinoic acid or a salt thereof and derivatives thereof, retinoic acid analog (4-[[[8- (3,5-dimethylphenyl ) -2-Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3-methylphenyl) -2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[[8- (4-methylphenyl) ) -2-Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3,4- Dimethylphenyl) -2-naphthaleni ] Carbonyl] amino] benzoic acid, 4-[[[8- (2,4-dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-isopropylphenyl) -2 -Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-ethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-fluorophenyl) -2 -Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methoxyphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(8-benzyl-2-naphthalenyl) carbonyl] Amino] benzoic acid, 4-[(E) -2- (8-phenyl-2-naphthalenyl) propenyl] benzoic acid), retinoic acid derivative (4-hydroxyphenylretinamide), retinoid analogue (4-[[( 5,6-dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) Amino] Kerr Bonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5, 5-dimethyl-8-ethyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) -carbonyl] amino] benzoic acid, 4- (E)-[2- (5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) -1-propenyl] benzoic acid, 4-[[((5,6-dihydro-5 , 5-Dimethyl-8-phenyl-2-naphthalenyl) oxy] carbonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] amino] Benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] oxy] benzoic acid, 4-[[5,6-dihydro-5,5- Dimethyl-8- (2-fluorophenyl) -naphthalenyl] carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5,6-trimethyl) ] -8-phenyl-2- (naphthalenyl) carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5,7-trimethyl-8-phenyl-2-naphthalenyl) carbonyl] benzoic acid, 4-[[((E)-(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] vinyl] benzoic acid, 4-[[[((5,6-dihydro-5,5 -Dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] sulfamyl] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] sulfamyl] carbonyl] benzoic acid Acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl -8-phenyl) -2-naphthalenyl] thiocarbonyl] amino] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] methyl] benzoic acid Acid, 4-[[[((5,6-Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] oxy] benzoic acid Acid 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthenyl] oxy] methyl] benzoic acid, 4-[[[((5,6-dihydro-5, 5-dimethyl-8- (2,4-dimethylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8- (4- Methylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4- [ [[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] sulfamyl] methyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8- Phenyl) -2-naphthalenyl] methyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] amino] thiocarbonyl] benzoic acid, 4 -[[[((5,6-Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] sulfamyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl - 8-phenyl-2-naphthalenyl] amino] methyl] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-hydroxy Benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-nitrobenzoic acid, 4-[[[((5,6 -Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-fluorobenzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-Naphthalenyl] carbonyl] amino] -2-methoxybenzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8- (2-naphthalene)]-2-naphthalenyl] carbonyl] amino ] Benzoic acid, 4-[[(5,6-dihydro-8-phenyl-2-naphthalenyl) carbonyl] aminobenzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl- 2-Naphthalenyl) carbonyl] amino] -3-fluorobenzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl) Enyl-2-naphthalenyl) carbonyl] amino] -3-methylbenzoic acid, 4-[[((5,8,10,10a-tetrahydro-10,10-dimethyl-9-phenyl-2-anthracenyl) carbonyl] amino] Benzoic acid, 4-[[(1,1-dimethyl-3-phenyl-1H1-inden-5-yl) amino] carbonyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-indene -5-yl-oxymethyl) benzoic acid, 4- [2- (1,1-dimethyl-3-phenyl-1H-inden-5-yl) vinyl] benzoic acid, 4-[(1,1-dimethyl- 3-phenyl-1H-indene-5-carbonyl) amino] benzoic acid), carotene or salts thereof and derivatives thereof (α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthine, lutein, zeaxanthin, isoseaxanthin, rhodoxanthine , Carotenoids such as capsanthin and crocetin), lycopene or its salts and derivatives thereof, vitamin B group: thiami Or salts thereof and derivatives thereof (thiamine hydrochloride, thiamine disulfide, bisbenchamine, bisbutiamine, thiamine monophosphate disulfide, benfotiamine, chicotiamine, octothiamine, discetiamine, fursultiamine, prosultiamine, astaxanthin Thiamine phosphate diester, etc.), thiamine sulfate, riboflavin or its salts and derivatives thereof (flavin adenine dinucleotide, flavin mononucleotide, riboflavin phosphate diester, 1-β-D-ribofuranosylnicotinamide pyrophosphate diester, 1 -β-D-ribofuranosylnicotinic acid, etc.), pyridoxine or its salts and derivatives thereof (pyridoxine 3,4-dipalmitate, pyridoxine 3,4-dicaprylate, pyridoxine sulfate diester, etc.), pyridoxer Or salts thereof and derivatives thereof, pyridoxamine or salts thereof and derivatives thereof, cyanocobalamin or salts thereof and derivatives thereof, cobalamines (such as methylcobalamin, adenosylcobalamin, hydroxocobalamin, aquacobalamin), folic acid or salts thereof, and Derivatives thereof, nicotinic acid or salts thereof and derivatives thereof, pantothenic acid or salts thereof and derivatives thereof, biotin or salts thereof and derivatives thereof, choline or salts thereof and derivatives thereof, inositol or salts thereof and derivatives thereof , Vitamin C group: ascorbic acid or a salt thereof and derivatives thereof, vitamin D group: ergocalciferol or a salt thereof and derivatives thereof, cholecalciferol and a salt thereof and derivatives thereof (1α-hydroxy-22-[(1 -Hide Xyl-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1R, 4R] -1α-hydroxy-22-[(1- Hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1R, 4S] -1α-hydroxy-22-[(1- Hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1S, 4R] -1α-hydroxy-22-[(1- Hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1S, 4S] -1α-hydroxy-22-[(1- Hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, etc.), dihydrotaxosterol or a salt thereof and derivatives thereof, vitamin E group : Tocopherol or a salt thereof and derivatives thereof, Tocotrie Nord or salt thereof and derivatives thereof, ubiquinone or salt thereof and derivatives thereof, vitamin K group: phytonadione or salt thereof and derivative thereof, menaquinone or salt thereof and derivative thereof, menadione or salt thereof and derivative thereof, menadiol Or salts thereof and derivatives thereof, vitamin F group: linoleic acid or salts thereof and derivatives thereof, linolenic acid or salts thereof and derivatives thereof, arachidonic acid or salts thereof and derivatives thereof, carnitine or salts thereof and Derivatives, ferulic acid or a salt thereof and derivatives thereof, γ-oryzanol or a salt thereof and derivatives thereof, orotic acid or a salt thereof and derivatives thereof, vitamin P group: rutin or a salt thereof and derivatives thereof, eriocitrin or a derivative thereof Salt and it Derivatives, hesperidin or salts thereof and derivatives thereof, vitamin L group: anthranilic acid or salts thereof and derivatives thereof, adenylthiomethylpentose or salts thereof and derivatives thereof, vitamin U group: methylmethionine sulfonium chloride or derivatives thereof , Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, Histidine or its derivatives (N-octyloxycarbonyl-β-alanyl-L-histidine, N-dodecyloxycarbonyl-β-alanyl-L-histidine, N- (12-amino-1-oxo Dodecyl) -L-histidine, N-2-ethylhexyloxycarbonyl-β-alanyl-L-histidine hydrochloride, N-hexadecyloxycarbonyl-β-alanyl-L-histidine, N-octylaminocarbonyl-β-alanyl- L-histidine, N-dodecylaminocarbonyl-β-alanyl-L-histidine, N-dodecylsulfonyl-β-alanyl-L-histidine, N-dodecylamino-oxalyl-β-alanyl-L-histidine, etc.) Amino acids such as sulfates, phosphates, nitrates, citrates or amino acid derivatives such as pyrrolidone carboxylic acid, α-hydroxy acids such as glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, succinic acid, 2-hydroxycarboxylic acids (methyl lactic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid, 2-hydroxyheptanoic acid, 2-hydroxy Tannic acid, 2-hydroxynonanoic acid, 2-hydroxydecanoic acid, 2-hydroxyundecanoic acid, α-hydroxylauric acid, α-hydroxymyristic acid, α-hydroxypalmitic acid, α-hydroxystearic acid, α-hydroxyarachidonic acid , Cerebronic acid, α-hydroxynervonic acid, mandelic acid, benzylic acid, phenyllactic acid, atrolactic acid, 2- (4'-hydroxyphenyl) -2-hydroxyethanoic acid, 2- (4'-chlorophenyl) -2-hydroxy Ethanoic acid, 2- (3′-hydroxy-4′-methoxyphenyl) -2-hydroxyethanoic acid, 2- (4′-hydroxy-3′-methoxyphenyl) -2-hydroxyethanoic acid, 3- (2 ′ -Hydroxyphenyl) -2-hydroxypropanoic acid, 3- (4'-hydroxyphenyl) -2-hydroxypropanoic acid, 2- (3 ', 4'-dihydroxyphenyl) -2-hydroxyethanoic acid, glyceric acid, erythrone Acid, ribo Acid, arabinonic acid, xylonic acid, lyxonic acid, aronic acid, altronic acid, gluconic acid, mannonic acid, gulonic acid, idonic acid, galactonic acid, taronic acid, glucoheptonic acid, galactoheptonic acid, tartronic acid, mucinic acid, etc. Hydroxycarboxylic acid or hydroxypolycarboxylic acid (gluconolactone, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, saccharide lactone, pantoyl lactone, glucoheptonolactone, mannonolactone, galactoheptono Lactones), 2-keto acids (glyoxylic acid, methyl 2-ketoethanoate, benzoylformic acid, methyl benzoylformate, ethyl benzoylformate, phenylpyruvic acid, methyl phenylpyruvate, ethyl phenylpyruvate, 2-ketobutanoic acid, 2- (Ketopentanoic acid, 2-ketohexanoic acid, 2-ketoheptanoic acid, 2-ketooctanoic acid, 2-ketododecanoic acid, methyl 2-ketooctanoate, etc.), quinic acid, isocitric acid, tropic acid, tretocanic acid, 3-chlorolactic acid, cerebronic acid , Citramalic acid, agaricinic acid, aleuricinic acid, pantoic acid, lactobionic acid, hexulosonic acid, photosensitizer 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, pentadecanoic acid glyceride, linolenic acid or derivatives thereof, eicosapentaenoic acid or derivatives thereof Docosahexaenoic acid or a derivative thereof, estradiol, etenyl estradiol, antialol or a glycoside thereof, lionilesinol or a glycoside thereof, rhododendrol or a glycoside thereof, platyphyronol or a glycoside thereof, a lactone compound (D -Guruk Rono-6,3-lactone, α-D-glucoheptonic-γ-lactone, δ-glucuronolactone, α, β-glucooctonic-γ-lactone, L-glonic-γ-lactone, γ-D- Galactonolactone, D-saccharide-1,4-lactone, D-saccharide-3,6-lactone, D-ribonic-γ-lactone, α-butyrolactone, γ-butyrolactone, α-octanoic lactone, γ-octa Neutic lactone, Nonanoic lactone, γ-valerolactone, D-manninoic-δ-lactone, D-xyleuic-δ-lactone, D-arabinoic-δ-lactone, stearoyl-δ-gluconolactone, DL-pantolactone, Palmitoyl-DL-pantolactone, etc.), 3-hydroxy-3,4-dicarboxy-1,4-butanolide or derivatives thereof, 6-benzylaminopurine or derivatives thereof, 1,4-diazadicyclooctane, 2,5 -Dimethylfuran, 2 -Methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran, rutin, tectrigenin 7-xylosylglucoside, captopril, alacepril, lisinopril, enalapril, delapril, benazepril, cilazapril, imidapril, quinapril, trandlapril Perindopril, temocapril, losartan, endothelin, galactomannan saccharide polymer, mucin, trimethylglycine, proteoglycan, lactic acid bacteria extract, lactic acid bacteria culture extract, lactic acid bacteria fermented milk extract, bifidobacteria extract, bifidobacteria culture extract, bifidobacteria fermented milk extract, Placenta extract, reishi extract, spleen extract, thymus extract, yeast extract, yeast culture extract, yeast fermentation extract, filamentous fungus extract, filamentous fungus culture extract, basidiomycete extract, basidiomycete Culture fluid extract, Bacterial cell disruption extract, Bacterial culture fluid extract, Cultured human dermis cell disruption extract, Red sage extract (Early yellow) extract, Fennel (mushroom) extract, Ezokogi (Tomogoka) extract, Barley (barley) extract, O Kururi Higotai (Zhengzhou Leopard) Extract, Root-knotweed Extract, Hypericum perforatum Extract, Dutch Jelly Extract, Dutch Honeybee Extract, Silkworm Extract, Roman Chamomile Extract, Garcinia Extract, Kawaran Ginseng (Blue Panax) Extract, Kakiran Extract, Kiraya Extract, Golden orchid extract, Ginkgo biloba extract, Calendula extract, Sakaneran (Ezosakakaneran) extract, Sababagin orchid extract, Sawagurumi extract (Plum) extract, Shimosukeso extract, Shajin extract, Plum extract, Gurumi extract, Sugina extract, Pineapple Pull extract, Chinese cabbage extract, Japanese cypress (shooting) extract, beech extract, physalis (Torone) extract, maitake (maiko) extract, Misohagi (Chikuma) extract, Mukuge (Kiso) extract, Mukuroji (life extension skin) extract, sprout Extract, Eucalyptus extract, Yukinoshita (tiger ear grass) extract, Suabisimus (cool) extract, Lettuce (Chisha) extract, Aloe extract, Ogon extract, Tonka bean extract, Gentianana extract, Burdock extract, Shikon extract, Carrot extract, Hamamelis extract, Hop extract, Yokuinin extract, Odorikosou extract, Senburi extract, Toki extract, Ginseng extract, Achacha extract, Hypericum extract, Cucumber extract, Ginger extract, Rosemary extract, Parsley extract, Sanadagusa extract, Fukurinamiji extract, Gatsu Lacombe Extract, Oyster Kumbu Extract, Oni Kumbu Extract, Gohei Kombu Extract, Naga Kumbu Extract, Pea Kombu Extract, Ouchimikombu Extract, Rattle Extract, Rattle Rape Extract, Beni Mozuku Extract, Hoso Beni Mozuku Extract, Kagekinori Extract, Ezotosaka Extract , Silamo extract, birch extract and the like.

Antioxidants Antioxidants can be added to the products of the present invention. Specific examples of antioxidants include ascorbic acid or a salt thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl hydroxyprophosphate, 5-o-α -D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid Sulfate aluminum Nium salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyranosyl -L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl-L -Ascorbic acid, 6-o-alkylascorbic acid potassium phosphate, 6-o-alkylascorbic acid phosphate calcium Um salt, 6-o-alkyl ascorbic acid phosphate barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o-alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl ascorbine Acid phosphate ester diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine Salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate Cholesterol ester, L-ascorbyl palmitate, L-isopalmitate Scorbyl, L-ascorbyl dipalmitate, L-ascorbyl diisopalmitate, L-ascorbyl stearate, L-ascorbyl isostearate, L-ascorbyl distearate, L-ascorbyl diisostearate, L-ascorbyl myristate, isomyristic acid L-ascorbyl, dimyristic acid L-ascorbyl, diisomyristic acid L-ascorbyl, 2-ethylhexanoic acid L-ascorbyl, di-2-ethylhexanoic acid L-ascorbyl, oleic acid L-ascorbic acid, 2-o-α -D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D- Glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitin Ester, L-Ascorbic acid tetralauric acid ester, L-Ascorbic acid tetra-2-ethylhexanoic acid ester, L-Ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol Ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbine Acid triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl] -4 ' -Acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphate diester, ascorbic acid boar Binding derivatives, ascorbic acid phosphoramide derivatives, ascorbic acid arbutin conjugates, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivatives, ascorbic acid sialic acid derivatives, etc.), stearates, tocopherols or salts thereof and derivatives thereof (α-tocopherol , Β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate, tocopherol succinate , Tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl Glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-toco Ferryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ- Tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ -Tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- (sulfoethylamino) -3- (α-tocopheryl-6- (Iloxy) propan-2-ol, 1- (carbo Cypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-Tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxy Propyl] aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ- Tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate), dihydropyridine derivatives (methyl-3- Enyl-2-propenyl 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) pyridine-3,5-dicarboxylate and its salts), benzochroman derivatives, nordihydrogua ceretenoic acid, butyl Hydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, coenzyme Qn (n = 7-10), pyrroloquinoline quinone, propyl gallate, sesamol, sesamolin, gossypol, maritimane, sulfretin, xanthene -2,7-diols, caffeoylquinic acids, propolis, carotenoids (α-carotene, β-carotene, γ-carotene, lycopene, lutein, violaxanthin, spiroloxanthine, spheroidene, astaxanthin, etc.), fluorotannin, Akebi extract, Achacha extract, Oolong Chaeki , Dutch bay extract, kanran extract, kumquat extract, goby extract, ginseng extract (old lady's grass) extract, sesame extract, sesame cultured cell extract, sesame extract, ginseng extract, rice bran extract, pomegranate extract, salamander extract, pear Extract, Daio extract, Tomato extract, Nanten extract, Noami (Otsuchi) extract, Neubara extract, Paprika extract, Pistachio extract, Biwa extract, Betel nut extract Buffalo extract, Bokeh extract, Hosobaoguruma extract, Mao (mao) extract, Mimosa extract, Mebouki extract, Himekuma willow extract, Yanagita extract, Watafujitsugi extract , Akaba Miuchiwa extract, Examples include Hypericum extract, Clam extract, Clove extract, Melissa extract, Enmezo extract, Birch extract, Salvia extract, Rosemary extract, Nanten extract, Ginkgo biloba extract, Green tea extract, Clove extract and the like.

Active oxygen scavenger / radical scavenger An active oxygen scavenger / radical scavenger can be added to the product of the present invention. Specific examples of active oxygen scavengers and radical scavengers include superoxide dismutase, catalase, glutathione peroxidase, bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or derivatives thereof, gallic acid or salts thereof, and derivatives thereof, curcumin Or salts thereof and derivatives thereof, transferrin, ceruloplasmin, coenzyme Qn (n = 7 to 10), uric acid, bilirubin, metallothionein, stilbengaloyl glycoside (3,5,4′-trihydroxystilbene 4′-o -β-D- (6 "galloyl) glucopyranoside, 3,5,4'-trihydroxystilbene 4'-o-β-D- (2" galloyl) glucopyranoside, etc.), chlorogenic acid phospholipid ester, chlorogenic acid sphingosine ester And derivatives thereof, chlorogenic acid glycolipid ester, chlorogenic acid sugar Steal, chlorogenic acid sterol ester, thiazole derivative or salt thereof (2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxyphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- [3-carboxy-4-hydroxy-5- (2-methyl-2-propenyl) phenyl] thiazole and 2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxy- 5-methylphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- (3-carboxy-5-methoxyphenyl) thiazole), hydroxymatylesinol, allohydroxymatylesinol, hydantoin derivatives, (Logwood) extract, Akagasiwa (red bud) extract, Acamino red extract, Japanese red plant extract, Japanese red radish extract, Hydrangea (hydrangea) extract, Abemaki extract, Fig extract, Ginkgo biloba extract, Asparagus Extract, Japanese apricot extract, Japanese white extract, Japanese walrus extract, Estragon extract, Enju (Japanese cypress, Japanese rice) extract, Japanese oak (Japanese cypress, Japanese coconut leaf) extract, Japanese cabbage extract, birch extract, birch extract, Kunugi extract, Oleander extract, Kumiko mandarin (Koji, Tachibana, Obenimikan, Fukurikukan, Sagamikoji, Ponkan) extract, Santara extract, Coffee extract, Comfrey extract, Sasa extract, Perilla extract, Aojiso extract, chili mushroom extract, catamen diso extract, peonies (glaze) extract, Japanese oak extract, mizunara extract, crape myrtle extract, dicoppi extract, white birch extract, white clover (clover) extract, horseradish extract, black tea extract, green tea extract, tsububuki Extract, tencha (bamboo tea) extract, tender eel extract, nani waibara (gold cherry tree) extract, peanut (peanut) extract, kei extract, nikkei extract, ceylon nicki extract, yabuni kei (cinnamon) extract, keishi (katsushi) extract, nozenkazura Extract, Lotus (Lotus) Extract, Chinese cabbage extract, Hadamakugi Extract, Hanasuge (Kamika) Extract, Hermanus (Maika Flower) Extract, Rose (Rose) Extract, Barbasco Extract, Spinach Extract, Beech Extract, American Beech Extract, Dog Beech Extract, European beech extract, Convolvulus extract, Hosobaokera (蒼朮) extract, Button (peony) extract, Mayoram (Annelida) extract, Melon extract, Oenothera extract, Snowy willow extract, Orchid extract, Lacanca extract, Rooibos extract, Naminohana extract, Yukarie Vinegar, bombardier Yukari extract, Azusaekisu, basil extract, woodworking (climate) extract, Hime Fuuro extract, lemon grass extract, and the like.

Fat metabolism promoter A fat metabolism promoter can be added to the product of the present invention. Specific examples of fat metabolism promoters include phthalazine derivatives (4-ethyl-1- (β-hydroxyethylamino) phthalazine, 4-N-propyl-1- (β-hydroxyethylamino) phthalazine, 4-N-butyl- 1- (β-hydroxyethylamino) phthalazine, 4-N-butyl-1- (β-hydroxypropylamino) phthalazine, etc.), xanthine derivatives (caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, diprofylline, proxy) Phyllin and oxtriphilin, etc.) Extract, Gajuttsu (boiled) extract, Chrysanthemum salmon extract, Kyoko Root) Extract, Ivy Extract, Pepper (Pepper) Extract, Cola Acminata Extract, Sagiomodaka (Sawamata) Extract, Pomelo Extract, Sansyuyu (Yamamuro) Extract, Tsuba Rafuji Extract, Ootsuki Rafuji Extract, Choreimaitake (Amber) Extract, Clover Extract , Prickly pear extract, red ginseng extract, ginseng extract (dragon gall) extract, naginata kouju extract, banana extract, puer tea (common ear tea) extract, plum extract, boufu (windproof) extract and the like.

UV protection agent / UV absorption promoter A UV protection agent / UV absorption promoter can be added to the product of the present invention. Specific examples of UV protection agents and UV absorption accelerators include benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5- Sodium sulfonate, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), 1,2-dihydroxy-4- (2-hydroxyethyl) benzene derivatives (1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) -3- Rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (2-acetyl-4- (3,4-dihydroxycinnamoyl) -3-rhamno L) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (2-acetyl-6- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (6- (4-hydroxy-3-methoxycinna) Moyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-methoxyethyl-3, 4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-hydroxyethyl-3,4-dihydroxybenzene, 1- (2- (6- (3,4-Dihydroxycinnamoyl) -3-xylosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (3-arosyl-6- (3-hydroxy-4-methoxycinnamoyl) ) Glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (3-glucosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1 -(2- (3-Allosyl-6- (3-hydroxy-4-methoxycinnamoyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (4- (3,4-dihydroxycinna Moyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (3- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (2 -(3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene Paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, paradimethyla Amyl benzoate, octyl paradimethylaminobenzoate, etc.), methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, paramethoxycinnamic acid Potassium, diparamethoxycinnamate mono-2-ethylhexanoate glyceryl, etc.), anthranilic acid derivatives (such as methyl anthranilate), urocanic acid derivatives (such as urocanic acid, ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, Tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, pyridoxine derivatives, Pyridoxal derivative, pyridoxamine derivative, amethoflavone, neosacranin, 6-dehydrocarbine, triazine derivative (4,4'4 "-(1,3,5-triazine-2,4,6-triyltriimino) trisbenzoic acid tris- 2-ethylhexyl etc.), phosphatidyl chromanol derivatives (1,2-dilaurylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman 1,2-dimyristoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-dipalmitoylglycero-3- Phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-distearoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-Tetramethyl-6'-hydroxychroman, 1,2-dialachidonylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'- Tramethyl-6′-hydroxychroman, 1-myristoyl-2-palmitoylglycero-3-phospho-2′-hydroxymethyl-2 ′, 5 ′, 7 ′, 8′-tetramethyl-6′-hydroxychroman, 1- Myristoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-palmitoyl-2-myristoylglycero-3-phospho -2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-palmitoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6'-hydroxychroman, 1-stearoyl-2-myristoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetra Methyl-6′-hydroxychroman, 1-stearoyl-2-palmitoylglycero-3-phospho-2′-hydroxymethyl-2 ′, 5 ′, 7 ′, 8′-tetramethyl-6′-hydroxychroman, etc.) , L-carnosine zinc complex, umbelliferone, esculin, benzyl cinnamate, cinoxalate, oxybenzone, dioxybenzone, octabenzone, soribenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, chlorophylls, xanthophylls , Escalol, Zinc Oxide, Talc, Kaolin, Anthrac (Buckthorn) Extract, Hub Extract, Giant Plover Extract, Asamidori Shigusa Extract, Kawachigusa Extract, Kawatake Extract, Cypridosa Extract, Hassai Extract, Spirulina Extract, Iacashio Extract, Funori no Ushike Extract , Japonica extract, Hytengus extract, Oobusa extract, chinolimo extract and the like.

Astringents Astringents can be added to the products of the present invention. Specific examples of astringents include succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannins (tannic acid, hamamelitannin Acer tannin, tetragalloyl glucose, pentagalloyl glucose, hexagalloyl glucose, heptagalloyl glucose, octagalloyl glucose, nonagaroyl glucose, decagalloyl glucose, undecagalloyl glucose, dodecagalloyl glucose, etc. Gallotannins, telimaglandin I, telimaglandin II, casarictin, peduncraggin, geraniin, isotarkevin, granatin A, granatin B, ketulinic acid, keblagic acid, casuarinin, nuphalin, procyanidin B-2, Eladitannins such as thiacinensin A and thiacinensin B), red grape extract, red bean extract, altea extract, nettle extract, cascarilla extract, kapoch extract, guarana extract, ezoba strawberry extract, Dutch strawberry extract, shrimp strawberry extract , Nawashiro Strawberry Extract, Maple Strawberry Extract, European Raspberry Extract, Kidney Aloe Extract, Hawthorn Extract, Coustella Hakka Extract, Cowberry (Etsutachibana) Extract, Cola Vera Extract, Sugarcane Extract, Sinah Honoki Extract, Honeysuckle Extract Q) Extract, larch extract, elder extract, dandelion extract, centalium extract, white dandelion extract, mud dandelion extract, vine azuki bean extract, tsurutsu Akebi extract, Teuchigurumi extract, Tormentilla extract, Novara extract, Buttercup extract, Hagoromogusa extract, Castor extract, Grape extract, Prune extract, Veronica extract, Bisnaga extract, Bilberry extract, Mansuguru extract, Mitsugashi extract, Myrrh extract, Melissa extract, Examples include witch hazel extract, black willow extract, latania (chlamelia) extract, lemon extract, and dairy extract.

Anti-inflammatory agent / interleukin production inhibitor / histamine release inhibitor An anti-inflammatory agent / interleukin production inhibitor / histamine release inhibitor can be added to the product of the present invention. Specific examples of anti-inflammatory agents, interleukin production inhibitors and histamine release inhibitors include quinolinone derivatives, dibenzooxepin derivatives, thiotroposin, phthalimide derivatives, flurbiprofen, felbinac, bufexamac, suprofen, 1,4-diphenylpropyl Piperazine derivatives, carxin compounds, chromanol glycosides (2- (α-D-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol), ictamol, indomethacin, kaolin, diphenhydramine hydrochloride, d- Camphor, DL-camphor, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, diphenhydramine hydrochloride, clemastine fumarate, cyproheptadine hydrochloride, hydrochloric acid Lomethazine, piperazine derivatives, α-D-phenylglycoside derivatives, glycyrrhizic acid or its salts and derivatives thereof (α-glycyrrhizic acid, β-glycyrrhizic acid, α-glycyrrhizic acid methyl ester, β-glycyrrhizic acid methyl ester, α-glycyrrhizin Trisodium acid, monopotassium α-glycyrrhizinate, dipotassium α-glycyrrhizinate, monoammonium α-glycyrrhizinate, trisodium β-glycyrrhizinate, monopotassium β-glycyrrhizinate, dipotassium β-glycyrrhizinate, monoammonium β-glycyrrhizinate ), Glycyrrhetinic acid or a salt thereof, and derivatives thereof (α-glycyrrhetinic acid, β-glycyrrhetinic acid, stearyl α-glycyrrhetinate, stearyl β-glycyrrhetinate, pyridoxine α-glycyrrhetinate, Pyridoxine ruretinate, glyceryl α-glycyrrhetinate, glycerin β-glycyrrhetinate, disodium 3-succinyloxyglycyrrhetinate, etc.), mefenamic acid, phenylbutazone, ibuprofen, ketoprofen, allantoin, calcium pantothenate, pantothenyl ethyl ether, etc. Panthenol or salts thereof and derivatives thereof, ε-aminocaproic acid, diclofenac sodium, tranexamic acid or derivatives thereof (trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexane) Carboxylic acid, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-bromobenzyloxycarbonylaminomethyl Cyclohexanecarboxylic acid, trans-4-m-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexane Carboxylic acid, sodium trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylate, ammonium trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylate Trans-4-p-bromobenzyloxycarbonylaminomethyl potassium cyclohexanecarboxylate, trans-4-m-chlorobenzyloxycarbonylaminomethyl Calcium tilcyclohexanecarboxylate, trans-4-p-methoxybenzyloxycarbonylaminomethyl magnesium cyclohexanecarboxylate, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexanecarboxylic acid monoethanolamine, trans-4-t-butyloxy Carbonylaminomethylcyclohexanecarboxylic acid, trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (3, 5-Dimethoxyphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid , Sodium trans-4-t-butyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylate, trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) Calcium cyclohexanecarboxylate, trans-4- (3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) magnesium cyclohexanecarboxylate, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid monoethanolamine, trans -4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarbo Acid, sodium trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylate, potassium trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4- (pyridine-4'-methyl Oxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylate potassium, trans -4- (pyridine-4'-methyloxycarbonylaminomethyl) cyclohexanecarboxylate sodium, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylate potassium, trans-4- (2- Trimethylsilyl Ethoxycarbonylaminomethyl) cyclohexanecarboxylate, etc.), sulfatide, astaxanthin fatty acid diester (astaxanthin dilaurate, astaxanthin dimyristate, astaxanthin dipentadecanoate, astaxanthin dipalmitate, astaxanthin dipalmitoleate, Astaxanthin diheptadecanoic acid ester, astaxanthin dielaidic acid ester, astaxanthin diricinoleic acid ester, astaxanthin petroselinic acid ester, astaxanthin vaccenic acid ester, astaxanthin eleostearic acid ester, astaxanthin punicic acid ester, astaxanthin ricinic acid ester, astaxanthin paris Naphosphate , Astaxanthin gadoric acid ester, astaxanthin 5-eicosenoic acid ester, astaxanthin 5-docosenoic acid ester, astaxanthin cetolic acid ester, astaxanthin erucic acid ester, astaxanthin 5,13-docosadienoic acid ester, astaxanthin ceracholic acid ester, astaxanthin decenoic acid Ester, astaxanthin steric acid ester, astaxanthin dodecenoic acid ester, astaxanthin dioleic acid ester, astaxanthin distearic acid ester, astaxanthin dieicosapentaenoic acid ester, astaxanthin didocosahexaenoic acid ester, astaxanthin dilinolenic acid ester, astaxanthin dilinolenic acid ester, astaxanthin diester Arachidonic acid ester ), Astaxanthin diglycerophosphate (astaxanthin diglycerophosphate, astaxanthin lyserophosphate palmitate, astaxanthin lysephrophosphatidylcholine palmitate, astaxanthin lysephrophosphatidylcholine DHA, astaxanthin lysephrophosphatidylinositol palmitate, astaxanthin Fattidylinositol DHA, astaxanthing lyserophosphatidylinositol linoleic acid, astaxanthing lyserophosphatidylcholine linoleic acid, etc.), steviol glycosides, benzimidazole derivatives (1- (2-ethoxyethyl) -2- [1- (2 -(4- (1- (4,4-Dimethyl-2-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4 -(2- (4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoic acid, ethyl 2- [4- (2- ( 4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanate, 1- (2-ethoxyethyl) -2- [1- ( 2- (4- (1,1-dimethyl-2-hydroxyethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 1- (2-hydroxyethyl) -2- [1- (2- (4- (1- (4,4-Dimethyl-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- ( 4- (1- (2-hydroxyethyl) benzoimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoic acid), alanine derivatives or salts thereof (N- [3-isopentyl- 4-Methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H- Azoline-5-carbonyl] -L-alanine, N- [3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl] -2- Methylalanine, N- [3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl] -N-methyl-L-alanine, etc.) Thiazoline derivative or its salt (3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid, 4-isobutyl-3-methyl-2- [4- (3-trifluoromethylbenzamide) benzoylimino] -3H-thiazoline-5-carboxylic acid, etc.), chlorpheniramine maleate, diphenhydramine hydrochloride, diphenylpyramine hydrochloride, carbinoxamine maleate, hydrocortisone butyrate, sulfated acidic mucos Polysaccharide or salt thereof Sulfated dextran or a salt thereof, fluoromethylhistidine or a hydrochloride thereof, histidine methyl ester or a hydrochloride thereof, licorice extract, sicon extract, age extract, propolis, eye (indigo leaf) extract, asenyaku (asen drug) extract, avocado extract, amadocoro (Bamboo bamboo) extract, Amiga lily extract, Baimo (shellfish mother) extract, Igakozorina (ground bile head) extract, Ibukitoranoo extract, Turmeric (Usu gold) extract, Echinashi (Hosobamurasakibarengiku) extract, Auren (Yoren) extract, Oguruma (turnover) extract, Hypericum persimmon (Brother cut grass) extract, Onigurumi extract, Orange extract, Cassia extract, Kamiyatsude (Tongweed) extract, Kawamidori extract, Kawara mugwort (Cotton chin) extract, Watercress extract, Kenashi Sartori Ibaraki , Gentian extract, co Ukisekoku extract, Kouhon (Kakimoto, Karamoto) extract, Koryokyo (Kora Kaki) extract, Gosho strawberry (covered bonsai) extract, Psycho-ran extract, Cherry extract, Salvia (sage) extract, Diquitaris extract, Linden extract, Salamander extract , Indobodai extract, Shukushamitsu (sand seed, shredded sand) extract, Juzudama extract, White minten (Nanten) extract, Ivy extract, Psyllium extract, Yarrow extract (Milfoil) extract, Shirohagenega extract, Takasago Gorhihitai Extract, Takakawarabi (Spider spine) extract, Periwinkle extract (Rika) extract, Tomatoutsu rafuji extract, Tounin extract, Chigaya extract, Toga (winter coconut) extract, Dokudami (ten-drug) extract, Parsley (Netherlands jelly) extract, Shrimp Shishitsuri extract, Hamasuge (Katsukishi) extract, Hishi (Rhijimi) extract, Bellows oyster extract, Pepper quail (South rattan) extract, Bundou (mung bean) extract, Sandalwood extract, Butcher bloom extract, Pansy extract, Hosoba aragiku (painful) Extract, Mizurutennansho (Tennansei) extract, pheasant (fruit) extract, miracle fruit extract, scented extract, peach (peach) extract, cornflower extract, willow willow extract, mistletoe (willow parasite) extract, Yabukouji (purple gold beef) extract, Porcupine extract, Artemisia (bamboo leaf) extract, Rosemary (Mannenrou) extract, Itohimehagi extract, Futosuzumo extract, Tamajuzumo extract, Mizojuzumo extract, Urushigusa extract, Siwahige extract, Akamok extract, Togemoku extract, Akaba extract, Maruba Aqaba Extract , Spinach extract, dulse extract, una extract, belladonna extract, cypress extract, harimille (crustacean, cinnamon bark, coconut leaf) extract, Aozulan extract, sakaneran extract, sasabagin orchid extract (including varieties and origin species) extract , Valerian extract, primrose extract, senkyu extract, kyonin extract, honeysuckle extract, tokyo extract, fennel extract, peppermint extract, and the like.

Anti-seborrheic agent An anti-seborrheic agent can be added to the product of the present invention. Specific examples of the antiseborrheic agent include chroman derivatives, pyridoxine or salts thereof and derivatives thereof, pyridoxal or salts thereof and derivatives thereof, pyridoxamine or salts thereof and derivatives thereof, sulfur, Asa extract, (Continuous) extract, Dutch mustard (watercress) extract, valerian extract (valerian root) extract, clematis extract, bear sebacekis, savonso extract, rosewood extract, horse chestnut extract, soybean (soybean) extract, Tokinsenka (marigold) extract, Chinese yam Examples include extract, yam extract, nosen-halen extract, dandelion poppy (sect winter flower, sect winter) extract, yabgarashi extract, giant kelp extract, hijirimen extract, primrose extract, haius banori extract.

Antibacterial agent An antibacterial agent can be added to the product of the present invention. Specific examples of antibacterial agents include acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salashi powder , Iodine compounds, iodoform, 1-alkylcarbapenem compounds, N-substituted azepane derivatives or salts thereof, sorbic acid or salts thereof, propionic acid or salts thereof, salicylic acid or salts thereof, dehydroacetic acid, parahydroxybenzoic acid esters, 2 -Keto-3-deoxyoctanoic acid fatty acid esters, inositol deoxy derivatives (such as quercitol), inositol unsaturated derivatives (such as chonditol), inositol dimethyl ether, methyl inositol, inositol methyl ester Ether, inosamine, deoxyinosadiamine, shikimic acid, quinic acid, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol , Thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, Chlorobutanol, isopropylmethylphenol, elemol, vetiverol, patchouli alcohol, nonionic surfactant (polyoxyethylene lauryl ether, polyoxyethylene nonyl pheny Ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, Methylrosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal violet, germal, photosensitive element 101, photosensitive element 201, photosensitive element 401, N-long chain acyl basic amino acid derivatives and acid addition salts thereof, oxidation Zinc, hinokitiol, propolis, kudin extract, agi (Ayu) extract, asunaro extract, alpinia extract, katsudai (suzukuku) extract, Inubilu (Honagainubiu) extract, Aogatei extract, Haribiyueki , Ayuyu extract, Hagateto extract, Hosonagabiyu extract, Enmeiso extract, Warbler extract, Usubasaicin extract, Oshusaishin extract, Halibut extract, Ominae shrimp extract, Kajikazura , Kahoku salamander extract, chamomile extract, linden extract, red linden extract, yellow spider extract, caraway extract, betel extract, beetle extract, cranberry extract, grapefruit extract, celosia flower (chicken flower, chicken crown) extract, Bay bay extract, Koushinbara (monthly flower) extract, Copaiba balsam extract, Yamazakura extract, Edhigarashi extract, Miyaza cherry extract, Yoshino cherry extract, Kasami cherry extract, Kanza cherry extract, sugar beet extract, Sarashinashi Horse (Hemp) Extract, Sikunshi (Mikoshi) Extract, Birch Extract, Cinnamon Extract, Sorrel (Acid Model) Extract, Atlantic Dandelion Extract, Japanese Nezu (Etsumatsu) Extract, Japanese Pepper Extract, Wild Pepper Extract, Soka (Grass) Extract, onion extract, chicory extract, Korean senile (蕪 夷) extract, tsuruna (apricot) extract, tokon (root) extract, leek extract, leek extract, peach extract, patchouli extract, ganbanana (stone carp, (Ranju Shahua) extract, cypress extract, pimenta extract, Hirohakinagusa (bald bald eagle) extract, blackberry extract, hop extract, makuri (marine herb) extract, magnolia sprenger extract, Mizokakushi (half-sided lotus) extract, honey bee Extract, purple (purple) extract, moso bamboo extract, pokeweed (commercial land) extract, yukkae , Lobster extract, Lavender extract, Forsythia extract, Sylar forsythia extract, Prunus nomata extract, Tochaka (Yahazutsu no Mata) extract, Red-breasted extract, Anaanaosa extract, Human egusa extract, Hirohi-no-higusa extract, Ushito exosa extract, Irolo extract , Ishige extract, arame extract, tamamitadaki extract, tambanori extract, katanoori extract, cherry blossom extract, fujimatsumo extract, kawamozuku extract, aokawa mozuku extract, himeka mozuku extract, yakuchi (yachi) extract and the like.

Blood flow promoting agent and blood vessel stimulating agent A blood flow promoting agent and blood vessel stimulating agent can be added to the product of the present invention. Specific examples of blood flow promoters and vascular stimulants include tocopherol or salts thereof and derivatives thereof, tocotrienol or salts thereof and derivatives thereof, cephalanthin, carpronium chloride, eugenol derivatives (acetyleugenol, methyleugenol, methylisoeugenol, ethyl (Eugenol, ethylisoeugenol, eugenol salicylate, etc.), minoxidil, chili pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, L-menthol, camphor, benzyl nicotinate, cinnarizine, trazoline, acetylcholine, verapamil, ectamol , Α-borneol, cyclandelate, nonyl acid wallenylamide, capsaicin, gingerone, assembly extract, garlic extract, carrot extract , Aloe extract, Gentian extract, Toki extract, Ashitaba (Tomorrow) extract, Arnica extract, Ukiyagara (Sanryo) extract, Himewiku extract, Citrus unshiu (Chest) extract, Toucan beetle (coconut) extract, Oyster extract, Persimmon extract, Kina extract, Goldfish hen extract, Anemone beetle extract, Gubijinsou extract, Kouhone (river bone) extract, Burdock (beef bowl, beef coconut) extract, Sagaki Kyo (Yamabachi) extract, Sinalengyo extract, Ginger extract, Shobu (bamboo shoot, radish) extract, Hawthorn extract, assembly (powdered medicinal) extract, Daidai (orange peel) extract, tanjin (dansang) extract, thyme extract, chiketsu carrot (bamboo ginseng) extract, tsurudokudami (what neck crab) extract , Carrot (Yoteba ginseng) extract, Capsicum (bansho) extract, Toki (toll) , Japanese hornworm extract, Natsumikan extract, elderberry (bone-bone) extract, hazelnut (coconut) extract, Hashiridokoro (roth root) extract, mint (light load, light load) extract, Hamabou Fu (hama wind) extract, Higotai extract , Fujimodoki (Chojizakura, Camellia) extract, Black currant extract, Bodaiju (Aoki tree) extract, Merirot extract, Yuzu extract, Loquat extract, Japanese jelly extract, Hibiscus extract, Rosehip extract and the like.

Antiandrogen Agent An antiandrogen agent can be added to the product of the present invention. Specific examples of antiandrogens include follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendrone, 4 ′, 5,7-trihydroxy-8-prenylflavanone, 4 ′, 5,7-trihydroxy-8 -Prenyl flavone, 3,3 ′, 4 ′, 5,7-pentahydroxy-8-prenyl flavone, nicorandil, cyclosporine and the like.

Structural proteolytic enzymes (elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme, etc.) Activity inhibitor / structural protein Degrading enzyme expression inhibitor The product of the present invention contains structural proteolytic enzymes (elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme Matrix metalloprotease) activity inhibitor / structural protease inhibitor can be added. Specific examples of structural proteinase activity inhibitors / structural proteinase expression inhibitors include adenine derivatives (butanetriol-9-adenine and its phosphate adduct, propanediol-9-adenine and its phosphate adduct, Pentanetriol-9-adenine and its phosphate adducts), carbostyril derivatives or salts thereof, dicarboxylic acids (glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, 1,9-nonamethylenedicarboxylic acid) Acid, 1,10-decamethylenedicarboxylic acid), rosmarinic acid, ursolic acid, oleanolic acid, hydroxamic acid derivative, esculetin derivative, anthocyanidins, nordihydroguaiaretech acid, 20-carboxy-16-hydroxy-21-nor- 5 α-7,9 (11) -lanostadien-3,24-dione, ubiquinone, plastaquinone, yugro , Shikonin, quinizarin, alizarin, abietin, levopimaric acid, betulin, α-amylin, catechin compounds (catechin, epigallocatechin, epigallocatechin gallate, epicatechin, epicatechin gallate, catechin rhamnopyranoside catechin, etc.), fluoro Diisopropyl phosphate, (2R, 6R) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate, N, N'-bis-[( 1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydroxyheptanedicarboxylic acid-1,7-diamide, (2R, 6R) -2, 6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane- Dimethyl 1,7-dicarboxylate, (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyl Tyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy -4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R)- 2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R)- 2,4,6-Trihydroxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2,6 -Dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, (2S, 6S) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7 Dimethyl dicarboxylate, dimethyl (2S, 6S) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate (2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2S, 6S) -2,6-dibenzyloxy- 4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2, 6-Dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-( 2R, 6R) -2,6-Dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, 3-[[4- (4-fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclopentyl) -Amino] -propionic acid, 4- [4- (4-fluorophenoxy) -benzenesulfonylamino] -tetrahydropyran-4-carboxylic acid hydroxyamide, 4- [4- (4-chlorophenoxy) -benzenesulfonylmethyl] -Tetrahydropyran-4-carboxylic acid hydroxyamide, 3-[[4- (4-fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclobutyl) -amino] -propionic acid, 4- (4'-chloro Biphenyl-4-yl) -2- [2- (1,3-dioxo-1,3-dihydroisoindol-2-yl) -ethyl] -4-oxobutyric acid, 1- [4- (4-fluorobenzyl) Oxy) -benzenesulfonyl] -2-hydroxycarbamoylpiperidin-3-yl) -carbamic acid isopropyl ester, 2- [4- (4-fluorophenoxy) -benzenesulfonylamino] -N-hydroxy-2-methylpropionamide, 3- [4- (4-Fluorophenoxy) -benzenesulfonyl] -2, N-dihydroxypropionamide, 3- (4-phenoxybenzenesulfonyl) -7-oxabicyclo [2.2.1] heptane-2-carboxylic acid hydroxy Amide, (4-benzylbenzyl)-[2- (2,2-dimethyl-1-methyl Rubamoylpropylcarbamoyl) -4- (4'-fluorobiphenyl-4-yl) -butyl] -phosphinic acid, 2-amino-3- [4- (4-fluorophenoxy) -benzenesulfonyl] -N-hydroxypropion Amide, N-Hydroxy-2- (4-phenylpiperidine-1-sulfonyl) -acetamide, Iris japonicus extract, Nepenthes (Summer hay) extract, Greater Crape myrtle (Banaba) extract, Large hawthorn extract, Hawthorn (Yamako) extract, Calahoo (Park) extract, guava extract, trash (Gomiko) extract, papaver extract, rose rose extract, Hypericum perforatum extract, chickweed extract , American Grape Extract, European Grape Extract, Yama Grape Extract, Mandarin Extract, Mishima Psycho (Shibahu) Extract, Ou Gon extract, Hypericum extract, Clara extract, Mulberry extract, Keihi extract, Gentian extract, Comfrey extract, Salvia extract, Elderberry extract, Body squirrel extract, Button pi extract, Aos zulan extract, Sakaneran extract, Sasabagin orchid extract, Chinese cabbage extract (variety and origin) (Including seeds) extract, red-green agave extract, sisal extract, garlic extract, and the like.

Structural protein synthesis promoter A structural protein synthesis promoter can be added to the product of the present invention. Specific examples of structural protein synthesis promoters include ethanolamine derivatives, pentoxyphyllin, serine derivatives, geraniol, crocetin, methyl 4- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-4- (3, 5,5-Trimethylhexyloxy) methyl benzoate, methyl 4-cyclohexylmethoxy-2-hydroxybenzoate, methyl 4- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4- (3,7-dimethyl-6 -Octenyloxy) methyl 2-hydroxybenzoate, ethyl 3- (2-ethylhexyloxy) -5-hydroxybenzoate, methyl 5- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-5 -(3,5,5-trimethylhexyloxy) methyl benzoate, methyl 5- (2-cyclohexylethoxy) -2-hydroxybenzoate, methyl 4-N-hexyloxy-2-hydroxybenzoate, 2-hydride Methyl xyl-4-N-octyloxybenzoate, methyl 4-N-decyloxy-2-hydroxybenzoate, methyl 5-N-hexyloxy-2-hydroxybenzoate, 4- (2-ethylhexyloxy) -2- Hydroxybenzoic acid, 2-hydroxy-4- (2,5,5-trimethylhexyloxy) benzoic acid, 4-cyclohexylmethoxy-2-hydroxybenzoic acid, 4- (2-cyclohexylethoxy) -2-hydroxybenzoic acid, 4- (3,7-dimethyl-6-octenyloxy) -2-hydroxybenzoic acid, 3- (2-ethylhexyloxy) -5-hydroxybenzoic acid, 5- (2-ethylhexyloxy) -2-hydroxybenzoic acid Acid, 5- (2-ethylhexyloxy) -2-hydroxybenzoic acid, 2-hydroxy-5- (3,5,5-trimethylhexyloxy) benzoic acid, 5- (2-cyclohexylethoxy) -2-hydroxybenzoic acid Acid, 4-N-hexyloxy-2-hydroxybenzoic acid, 5-N-hexyloxy-2 -Hydroxybenzoic acid, 2-hydroxy-4-N-octyloxybenzoic acid, 4-N-decyloxy-2-hydroxybenzoic acid, N- (2-hydroxyethyl) -4- (2-ethylhexyloxy) -2- Hydroxybenzamide, N-ethyl-4- (2-ethylhexyloxy) -2-hydroxybenzamide, 2-acetoxy-4-cyclohexylmethoxybenzoic acid, 4- (2-ethylhexyloxy) -2-hydroxybenzoic acid sodium, 4- [(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoate methyl, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] Ethyl-2-hydroxybenzoate, 5-[(2E) -3,7 dimethyl-2,6-octadienyloxy] -2-hydroxyethyl benzoate, 3-[(2E) -3,7-dimethyl- Ethyl 2,6-octadienyloxy] -2-hydroxybenzoate, ethyl 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -5-hydroxybenzoate, 4- [(2E) -3,7-dimethyl-2,6-octadienyloxy] -3-methoxybenzoate, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10 -Dodecatrienyloxy] -2-hydroxybenzoic acid methyl, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid (2E) -3,7- Dimethyl-2,6-octadienyl, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid, 5-[(2E) -3,7-dimethyl- 2,6-octadienyloxy] -2-hydroxybenzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid, 3-[(2E ) -3,7-dimethyl-2,6-octadienyloxy] -5-hydroxybenzoic acid, 2-hydroxy-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10 -Dodecatrienyloxy] benzoic acid, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -3-methoxybenzoic acid, 2-acetoxy-4-[(2E) -3 , 7-Dimethyl-2,6-octadienyloxy ] Benzoic acid, N- (2-hydroxyethyl) -4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzamide, 4-[(2E) -3, 7-dimethyl-2,6-octadienylamino] -2-hydroxybenzoic acid, dimethyl-2,6-octadienyloxybenzoic acid, N- (2-hydroxyethyl) -4-[(2E) -3 , 7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienylamino] -2-hydroxybenzoic acid, 3 -Dodecyloxybenzoic acid, 3- (12-hydroxydodecyloxy) benzoic acid, 4-dodecyloxybenzoic acid, 4- (12-hydroxydodecyloxy) benzoic acid, 3- (12-hydroxyoctadecyloxy) benzoic acid, 4 -(12-hydroxyoctadecyloxy) benzoic acid, 3- (11-hydroxyundecyloxy) benzoic acid, 4- (11-hydroxyundecyloxy) benzoic acid, 3-[(2E) -3,7-dimethyl- 2,6- Tadienyloxy] benzoic acid, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, 3-[(2E, 6E) -3,7,11-trimethyl-2,6 , 10-dodecatrienyloxy] benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4- [3,7-dimethyl -9- (2,6,6-trimethyl-1-cyclohexen-1-yl) -2,4,6,8-nonatetraenyloxy] benzoic acid, 4- [3,4-dihydro-2,5, 7,8-Tetramethyl-2- (4,8,12-trimethyltridecyl) -2H-1-benzopyran-6-oxy] benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl -2,6,10-dodecatrienyloxy] benzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzamide, 4- (2-methyl-2-butenyloxy) benzamide 4- (2-ethylhexyloxy) benzamide, 4-dodecyloxybenzamide, 4- (12-hydroxydodecyloxy) benzamide, 4- (12-hydroxyoxy) Tadecyloxy) benzamide, 4- (11-hydroxyundecyloxy) benzamide, 4- (10-hydroxydecyloxy) benzamide, 4-isostearyloxybenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E ) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzamide, N, N-dimethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6, 10-dodecatrienyloxy] benzamide, N, N-di [(2E) -3,7-dimethyl-2,6-octadienyl] -4-aminobenzamide, 4- [N'-methoxycarbonyl-N-[( 2E) -3,7-dimethyl-2,6-octadienylamino] benzamide, 4- [N-acetyl-N-[(2E) -3,7-dimethyl-2,6-octadienyl]] aminobenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, N, N-diethyl-4 -[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyl Xy] -2-hydroxybenzamide, pea extract, red pepper extract, scots reed extract, hosobonori extract, bonito extract, igisu extract, keigi extract, harii squirrel extract, honey beet extract, euglena extract, moly rush extract, Willow extract, Willow extract, Motsuyurena extract, Venetian extract, Moth willow extract, Sabaya willow extract, Wasabi extract, Merbow extract and the like.

Mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitor A mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitor can be added to the product of the present invention. Specific examples of mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitors include anacardic acid or its derivatives (6-pentadecatrienylsalicylic acid methyl ether, 6-pentadecatrienylsalicylic acid ethyl ether, 6-pentadecaic acid). Trienyl salicylic acid propyl ether, 6-pentadecatrienyl salicylic acid butyl ether, 6-pentadecatrienyl salicyl alcohol methyl ether, 6-pentadecatrienyl salicyl alcohol ethyl ether, 6-pentadecatrienyl salicyl alcohol propyl ether, 6- Pentadecatrienyl salicyl alcohol butyl ether, 6-pentadecatrienyl salicylaldehyde methyl ether, 6-pentadecatrienyl salicylaldehyde ethyl ether, 6-pentadecatrienyl salicylaldehyde Propyl ether, 6-pentadecatrienyl salicylaldehyde butyl ether, 2-methyl ether-6-pentadecatrienyl cinnamic acid, 2-ethyl ether-6-pentadecatrienyl cinnamic acid, 2-propyl ether-6- Pentadecatrienyl cinnamate, 2-butyl ether-6-pentadecatrienyl cinnamate, 2-methyl ether-6-pentadecatrienyl cinnamate alcohol, 2-ethyl ether-6-pentadecatrienyl cinnamate Alcohol, 2-propyl ether-6-pentadecatrienyl cinnamic alcohol, 2-butyl ether-6-pentadecatrienyl] cinnamic alcohol, etc.), polyisoprenylated benzophenone derivatives (garcinol, isogarcinol, xanthothymol) , Isoxanthothymol, gucciferon, etc.), Ikarisou extract, Yachima Taikiso (Inyo) (October) extract, Narco lily extract, Occidental lily (Yellow spirit) extract, Oregano extract, Oshida extract, Onji extract, Spruce extract, Crow birch extract (half-summer) extract, Pheasant extract Skin) extract, goshyu extract, senega extract, sendan extract, tamarind extract, tarragon extract, ginkgo biloba extract, bee extract, daisy extract, mirabaran extract, himebara extract, Mockin Extract, Laurel Extract, Yabusotatsu Extract, Anaaaosa Extract, Macrocystis Integrifolia Extract, Neocitus Ruetkeana Extract, Nettle Extract, Prunus Extract, Kata-Bucka Extract, Yatabegusa Extract, Shimatengusa Extract, Ezotsunomata Kisses, Swallowtail extract, Fusiwa ivy extract, Hanemo extract, Mill extract, Chromel extract, Nagamil extract, Hiramil extract, Matsumo extract, Okinawa mozuku extract, Mozuku extract, Fukuronori extract, Kajime extract, Orochi nori extract, Mafnori extract, Grape leaf extract, Salamander extract, Astragalus extract etc. are mentioned.

Mucopolysaccharide synthesis promoter A mucopolysaccharide synthesis promoter can be added to the product of the present invention. Specific examples of the mucopolysaccharide synthesis accelerator include stilbene derivatives or salts thereof, morgin or salts thereof and derivatives thereof, N-acetylglucosamine, flax extract, cinnamon extract, mulberry extract, scotch extract, breadfruit extract, hirakotoji extract , Kotojitsu no Mata Extract, Yaleus Banori Extract, Kagiosu Banori Extract, Susius Banori Extract, Amiaosa Extract, Nagaaosa Extract, Hosobanosakamodoki Extract, Hirohatosakamodoki Extract, Yatsudegatatosakamodoki Extract, Kurotosakamodoki Examples include extract, Nezushinosakamodoki extract, Yusora extract, Etsukinotosakamodoki extract, Nankaitosakamodoki extract, Himetosakamodoki extract, and the like.

Intercellular lipid production promoter / intercellular lipid state improver An intercellular lipid production promoter / intercellular lipid state improver can be added to the product of the present invention. Specific examples of intercellular adipogenesis promoters and intercellular lipid state improvers include phospholipids (phosphatidylethanol, phosphatidylcholine, phosphatidyltriethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylglycerin, phosphatidylinositol, diacylphosphatidylcholine, diacylphosphatidylethanol Amine, diacylphosphatidylinositol, diacylphosphatidylserine, 1-cysteinylphosphatidic acid, 2-cysteinylphosphatidic acid, 1-glutathionylphosphatidic acid, 2-glutathionylphosphatidic acid, 1-azelaoylphosphatidic acid, 2- Azela oil phosphatidic acid, 1-hydroxyacyl phosphatidic acid, 2-hydroxyacyl phosphatidic acid, ceramide, glucosyl Lamide, galactosylceramide, cerebroside, phosphatidylglucosylacylglycerol, N-oleoylsphingosine, N- (12-hydroxyoctadecanoyl) sphingosine, N- (16-hydroxyhexadecanoyl) sphingosine, N-salicyloylphytosphingosine, Sphingomyelin, soybean lecithin, egg yolk lecithin, etc.), sterins (cholesterol, dihydrocholesterol, cholesteryl stearate, cholesteryl hydroxystearate, macadamia nut oil fatty acid cholesteryl, β-sitosterol, stigmasterol, campesterol, ergosterol, 5-dihydro Ergosterol, phytosterol, 25-hydroxycholesterol, 26-hydroxycholesterol, 19-hydroxycholesterol, 22-ketocholes Roll oxime, 6-ketocholesterol and 7-ketocholesterol or their derivatives), N-acetylneuraminic acid (sialic acid), N-glucosolneuraminic acid, gangliosides (gangliotriose, gangliotetraose , Globotetraose, neolactotetraose, neolactohexaose, neolactooctaose, etc.), oligosulfated hyaluronic acid, hydroxytamoxifen compounds, glyceroglycolipids, pentoxyphyllin, 3-deazaadenosine, carboxamide derivatives, Inositol polyamines, sialic acid, triterpenic acid derivatives, lactose, lactosamine derivatives, sulfated chitin derivatives, albumin, ginseng extract, tochiban ginseng extract, sea cucumber extract, red lily extract, green lily extract, chickweed extract And the like.

Keratin solubilizer and stratum corneum peeling accelerator A keratolytic agent and stratum corneum peeling accelerator can be added to the product of the present invention. Specific examples of keratolytic agents and stratum corneum exfoliation accelerators include tropolone and its derivatives, resorcin, lactic acid, urea, salicylic acid, guanidine, ethanolamine, kikarasuuri (Gurone) extract, fenugreek extract, wisteria bean extract, lentil extract Chickpea extract, mungbean extract and the like.

Plasminogen activator antagonist inhibitor A plasminogen activator antagonist inhibitor can be added to the product of the present invention. Specific examples of the plasminogen activator antagonist inhibitor include rabbit daisy extract, canamgra extract, caladium extract, raspberry extract and the like.

Maillard reaction inhibitor A Maillard reaction inhibitor can be added to the product of the present invention. Specific examples of Maillard reaction inhibitors include aminoguanidine, flavanones (naringin, naringenin, liquiritin, liquiritigenin, digallic acid, luteoic acid, ellagic acid, chlorogenic acid, glucogallin, tetralin, hamamelitannin, gallic tannin, tannic acid, (Geraniin, gallic acid, galloyl gallic acid, ellagitannin, hexagalloyl glucose, heptagalloyl glucose, tetragalloyl glucose, triggerroyl glucose, pentagalloyl glucose, digalloyl quinic acid, triggerroyl quinic acid), 2-hydroxyphenylalkylamine Derivatives or salts thereof, phenylpropenoic acid derivatives (3- [2,3-bis (methoxymethoxy) phenyl] propenoic acid, 7- (4-hydroxy-3-methoxyphenyl) hepta-2,4,6-trienoic acid, 3- (3,5-Dimethoxy-4-hydroxy (Roxyphenyl) propenohydrazide, N'-isopropylidene-3- (2-methoxyphenyl) propenohydrazide, etc.), citric acid or its salts, gypsum extract, sandalwood extract, red clover extract, persimmon (柿) (Including moths) Examples include Tarayo extract, Dokudami extract, Tormentilla extract, Bakumondo extract, Hiba extract, Grape extract, Japanese willow extract, Mukuroji extract, Karin extract, Mokka extract, Roman chamomile extract and the like.

Testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promoter A testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promoter can be added to the product of the present invention. Specific examples of testosterone 5α reductase activity inhibitor, hair papilla activator and hair growth promoter include γ-amino-β-hydroxybutyric acid esters (γ-amino-β-hydroxybutyric acid methyl ester, γ-amino-β- Hydroxybutyric acid ethyl ester, γ-amino-β-hydroxybutyric acid propyl ester, γ-amino-β-hydroxybutyric acid butyl ester, γ-amino-β-hydroxybutyric acid ethylhexyl ester, γ-amino-β-hydroxybutyric acid hexadecyl ester, γ-amino-β-hydroxybutyric acid lauryl ester, γ-amino-β-hydroxybutyric acid stearyl ester, γ-amino-β-hydroxybutyric acid oleyl ester, γ-amino-β-hydroxybutyric acid benzyl ester, γ-amino-β- Hydroxybutyric acid phenyl ester, γ-amino-β-hydroxybutyric acid ethyl glycol ester, γ-amino-β-hydroxy Acid sorbitol ester, γ-amino-β-hydroxybutyric acid polyoxyethylene glycol ester, γ-amino-β-hydroxybutyric acid glycerin ester, etc.), amine oxides (oleyl dimethylamine oxide, stearyl dimethylamine oxide, palmityl dimethylamine oxide) , Myristyl dimethylamine oxide, lauryl dimethylamine oxide, dimethyl lauryl ethoxyamine oxide, dihydroxyethyl lauryl amine oxide, coconut oil alkyl dimethylamine oxide, etc.), alkyl betaines (coconut oil fatty acid amidopropyl betaine, coconut oil alkyl betaine, lauryl dimethyl) Aminoacetic acid betaine, lauric acid amidopropyl betaine, lauryl hydroxysulfobetaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl Imidazolinium betaine), pyrimidine-N-oxide derivatives (2-amino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-6- (1-pyrrolidinyl) pyrimidine- 3-oxide, 2-amino-4-methyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-6- [1- (4-methylpiperazinyl)] pyrimidine-3-oxide, 2-amino-4- (1-hexahydroazepinyl) -6-methylpyrimidine-1-oxide, 2-amino-4-dimethylamino-6-methylpyrimidine-1-oxide, 2-amino-4-allylamino -6-methylpyrimidine-1-oxide, 2-amino-4-benzylamino-6-methylpyrimidine-1-oxide, 2-amino-4,5-methyl-6-piperidinopyrimidine-3-oxide, 2 -Amino-4-ethyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-5-nitro-6-piperidinopyrimidine-3-oxide, 2,5-diamino- 4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-5-piperidino -6- (1-pyrrolidinyl) pyrimidine-3-oxide, 2-methyl-4-amino-6-piperidinopyrimidine-3-oxide, 2-methyl-4-amino-5-bromo-6- (1- Pyrrolidinyl) pyrimidine-3-oxide, 2-methyl-4-amino-5-nitro-6-piperidinopyrimidine-3-oxide, 2-methyl-4,5-diamino-6-piperidinopyrimidine-3- Oxide, 2-methyl-4-amino-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-6-piperidinopyrimidine-3-oxide monohydrochloride, 2- Acetylamino-4-methyl-6-piperidinopyrimidine-3-oxide, 2,4-diamino-6-phenoxypyrimidine-3-oxide, 2,4-diamino-6- (2,4-dichlorophenoxy) pyrimidine -3-oxide, 2,4- Amino-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitroso-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4- Diamino-5-nitro-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4,5-triamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-bromo-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, etc. ), P-menthane-3,8-diol, monoglyceryl-D-glucoside monotridecanoate, 1-oN-pentadecylglycero-D-glucoside, monopentadecanoic acid glyceride sulfate, etc. -Monopentadecyl glyceryl ether sulfate, 1-o-hexadecyl-2-o-methylglycerin, 1-o-octadecyl-2-o-me Luglycerin, 1-o-oleyl-2-o-methylglycerin, acetylcarnitine or its salt, geranylgeranylacetone, hydroxamic acid derivative or its salt, gingerone glycoside, benzeneoxyacetic acid derivative ([5- [2- [1 -Phenyl-1- (3-pyridyl) methylideneaminooxy] ethyl] -7,8-dihydronaphthalen-1-yloxy] acetic acid), isorhamnetin-3-robinobioside, xanthone derivatives, proanthocyanidins (grape seed extract) Proanthocyanidins, apple-derived proanthocyanidins, pine-derived proanthocyanidins, purified procyanidin oligomers, procyanidin B-1, procyanidin B-2, procyanidin B-3, procyanidin C-1, etc.), aracaci extract, angelica extract, apricot extract , Hong anzu extract, Ichiyakuso (one herb) extract, Enishiidae Kiss, Psyllium (carrot, carp grass) extract, Psyllium shabushi extract, olive extract, giant pufferfish extract, seisei extract, calla cucumber extract, Chinese pear extract Camphor extract, kubeba extract, buckthorn extract, potato oyster extract, snapdragon extract, snapdragon extract, kippi extract, beetle extract, cilantro extract, kobushi extract, magnolia extract Extract, Consulango extract, Sasanqua extract, Sweet potato extract, Sunabune jujube (acid soy sauce) extract, Sandscon (Yamazu root) extract, Potato extract, Shishigashira Kiss, Sanshishi extract, Coriander extract, Stevia extract, Takatodai extract (Otsuchi) extract, Tarayo (Oba winter blue, Ichiha tea, bitter tea, bitter tea) extract, Taranoki extract, Nigaki (Nakiki) extract, Nurde (pentose) extract , Hakamauraboshi (bone crushing) extract, spider magnolia extract, scented squirrel extract, stag beetle extract, scallop extract, citron carrot (participant) extract, mangosteen extract, myoga extract, melaleuca extract, yashabushi extract, himeya chabushi extract , Oyaba chabushi extract, Yakumoso extract, Yamahanoki (Yamatake) extract, Longan (long-eye meat) extract, Lokon (Yoshi, Sone) extract, Logwood extract, Lantana extract and the like.

Hair matrix growth inhibitor / hair growth inhibitor A hair matrix growth inhibitor / hair growth inhibitor may be added to the product of the present invention. Specific examples of hair matrix cell growth inhibitor / hair growth inhibitor include phthalazinones, benzoxazinones, phosphonic acid derivatives, cyproterone, 5α-androstene-3α, 17β-diol, medroxyprogesterone, norethisterone, mestanolone, ichihatsu (First) extract, citrus extract, kanto extract, sanjiko extract, silamo extract, sardine extract, scabbard fern extract, fritillary extract, honeysuckle extract, seaweed extract, oleander extract and the like.

Hair swelling agent / hair protecting agent A hair swelling agent / hair protecting agent can be added to the product of the present invention. Specific examples of the hair swelling agent / hair protecting agent include ethanolamine, urea, guanidine, silicones, blueberry extract, mango extract and the like.

Odorous substance eliminating agent An odorous substance eliminating agent can be added to the product of the present invention. Specific examples of the odorous substance eliminating agent include Inondo extract, Elemi extract, vanilla bins extract, pine extract and the like.

Other additive components Specific examples of components derived from plant-based materials used as additives to the product of the present invention include Aokazura (Keifuto) extract, Aotenma extract, Akasuguri extract, Aquine (crust) extract, Aguay・ Guasu Extract, Abiu Extract, Abiurana Extract, Yellow Sapote Extract, Ylang Ylang Extract, Uranium Orchid Extract, Uba Tea Extract, Ezo Lilac Extract, Eun Boku Extract, Elderberry Extract, Eurasian Saki Yuki Extract, Sasano Yuki Extract, Eurasian Cactus Extract, Omi Acatetsu extract, Onoelan extract, Crab extract (Kinshato) extract, Karaya extract, Garyu extract, Kawaratake extract, Candelilla extract, Canna extract, Kidachi pepper extract, Kimenkaku extract, Cabbage extract, Kiraja saponaria extract, Ginseca Extract, kimbsen extract, guapeba vermelha extract, kugenumaran extract, gooseberry extract, crity river extract, curcrigo latifolia extract, black moth (rescue) extract, cucumber extract, sapotea mariyo extract, salmon berry extract, salamander extract , Cactus Cactus Extract, Cranberry Extract, Shunran Extract, Shozuk Extract, Shirobanatsuta Extract, Cinchona Sacylbra Extract, Swimberry Extract, Star Apple Extract, Sulgaran Extract Japanese butterfly extract, mistletoe extract, sennin cactus extract, senboku extract, elephant weevil extract, cinnamon extract, some mono-potato extract, Kuksito Cherry Extract, Prickly Pear Extract, Choconostay Extract, Datura Artemisia Extract, Vulgaris Extract, Tuxiabi Extract, Duckweed (Duckweed) Extract, Duberry Extract, Clover Extract, Tragacanth Extract, Triacanthus Extract, Neiseria berry extract, Rapeseed extract, Plover-dough extract, Pau-dose extract, Hakuruberry extract, Batata extract, Hamakakiran extract, Balata extract, Hulcan orchid extract, Pecan nut extract, Hinago duck extract, Himemuyoran extract, Brazilian carrot extract, Branjen extract, Frucellaria extract, Blond psyllium extract, Hetsukaran extract, Heneken extract, Berry extract, Persea extract, Pervianburg extract, Pereschia gu Randy Folia extract, Boysenberry extract, Hosairan extract, Pouteria sapota extract, Pouteria rukuma extract, Hosobabarengiku extract, White berry extract, Masaransuba extract, Masheira de Boyi extract, Matta auryo extract, Mulberry extract, Midori Sapote extract, purple corn extract, megacansa opuntica extract, mokukirin extract, Japanese maple extract, Morero cherry extract, Yakawa purple potato extract, cornflower extract, Ruritama thisami (Vultures), red currant extract, red pitaya Examples include plant extracts such as extract, lemongrass extract, wax palm extract, and logan berry extract.

  In addition, as specific examples of components derived from plant-based raw materials used as an additive to the preparation of the present invention, Dunaliella genus Dunaliella extract, Kuwanomi genus Kuwanomimo extract, Volbox genus genus sunflower extract, Volbox genus Volbox extract, Palmera extract, Yotsumemo extract, Aomydra spp. , Pseudomonas spp., Casanori spp. Extracts, green algae extracts such as Sumiremo violet, Hosimidro extract, Fuchinashimidoru extract, cyanobacteria suizengenori extract, blue-green algae extract such as Aoko extract, Yulemo extract, Piraella pirea extract, Shiamidomo Nagamisiomidro extract, Isovine genus isovine extract , Isogawala genus Isogawara extract, Black moth genus Black moth moth extract, Kashirazaki genus Kashirazaki essence, Muchimo genus Muchimo extract, Muchimo genus Hiramachimo extract, Muchimo genus Quercus crisposa extract, Amygusa genus Sakibiro amiji extract, Common genus genus Common genus extract, Jigamigusa genus digigagus Nami-makura genus Hirami-makura extract, Someraceae genus Someraceae extract, Navarimo genus Navarimo extract, Chasomen genus Mocha-chaumen extract, Ganoderma spp. Genus Composita extract, genus Camellia spp. Nori extract, genus Cyprus extract, genus genus genus extract, turmeric genus extract, genus chrome extract, chrysanthemum Brown algae extract such as Ishicombu genus Chrysanthemum extract, Uchimo spp. Milnobeni extract, Konahada spp. Sodegarami Sodegarami Extract, Hirohatamitaki Hirohatamitaki Extract, Tengusa Nambugusa Extract, Tengusa Kohira Extract, Tengusa Yohira Extract, Tengusa Kinukusa Kiss, Hibiro hibishiro extract, Hibiro hibishiro extract, Isomume genus Isommedo extract, Echinodera genus Extract, Ryumon genus Ryumon extract, Ryumon genus Hera ryumon extract, Niseka genus extract , Okitsubara Okibutsubara Extract, Sangomoda Ragarodoku Extract, Shiogusagoromo Shiogusagoromo Extract, Iwanokawa Etsukiiwakawa Extract, Kainokawa Kainokawa Extract, Kaninote Kaninote Extract, Sangomo Sangomo Extract Genus Hiram Cadet Extract, Centipede Genus Kyoko Spider Extract, Centipede genus Centipede Extract, Centipede Gentle Extract, Centipede Fudarak Extract, Mu Denori spp. Genus centipede extract, Kintoki genus Nagakintoki extract, Kintoki sp. Tsukasanoori Hanagakarimenia extract, Honoho genus Hounoo extract, Hikagenoito genus genus extract, Hikagenoit genus Usuginu extract, Kuwano spp., Venetian spp. Mizoogonori extract, Ogonori genus Beniogonori extract, Ogonori sp. Ogonori genus Ogonori extract, Ogonori genus tsutsuginu extract, Ogonori genus Ogonori extract, Ogonori Kubireogonori extract, Ogonori mosasagonori extract, Ogo Nori Kinubanori Extract, Namiiwatake Namiiwatake Extract, Saimi Italiasa Extract, Saimi Saimi Extract, Lotus Jigusa Lotus Jigsusa Extract, Black Haginnosa Black Haginnang Extract, Hishibukuro Hishibukuro Extract, Madaragus Togemadara Extract Extract Extract, Weibusa spp., Buffalo genus Benifu cranori extract, Vaccinium spruce extract, Ventura spp. , Egonori Egonori Extract, Egonori Futogigi Extract, Saeda Saeda Extract, Chilli Momiji Chilli Momiji Extract, Habutaenori Extract, Shirano Kori Extract, Suzushironori Extract, Usbeni Uusbeni Extract, Hasujiginu Hasujiginu Extract, Nagakonoha Nori Naga Extract , Sugiginus genus Sugiginu extract, Sugiginu genus Abususu gininu extract, Heius banori Kagious banori extract, Heius banori genus Yaleus banori extract, haius banori genus suus banori extract, haius banori genus euus banus extract, Ayanishiki Ayanishiki Extract, Ayaginu Ayaginu Extract, Dadia Enasidadia Extract, Shimadadia Isohagi Extract, Shimadadia Shimadadia Extract, Dazimod Genus damselfly extract, maca genus macaque extract, caterpillar genus extract, coral genus extract Odoshi extract, Hyodosig genus Hyodosigusa extract, Hyodosig genus Usubahiodori extract, Isomegusa genus Isomegusa extract, Suzyna genus Sugenashigusa extract, Isobasho genus Isobasho extract, Ideyugogome genus Yukogome extract, Ochimomoku genus Okijimoku Red algae extract such as genus Chisuginori extract, Shajikumo extract, Shirahamamo extract, Hoshitsurimo Hoshitsurimo extract, Rikunotumusu extract, Flasks Examples thereof include axle algae extracts such as peach extract, chaboflask extract and tripella extract, and yellow algae extracts such as Hikarimo Hikarimo extract.

  Specific examples of ingredients derived from animal materials used as an additive to the product of the present invention include chicken crown extract, cow, pig or human placenta extract, pig or cow stomach, duodenum, intestine, spleen extract or degradation thereof Products, bovine or pig brain tissue extracts, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolysates, elastin, elastin hydrolysates, water-soluble elastin derivatives, keratins and their degradation products or derivatives thereof, Silk protein and its degradation products or derivatives thereof, porcine or bovine blood cell protein degradation products (globin peptides), cattle or porcine hemoglobin degradation products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and its Decomposed product or derivative thereof, skim milk powder and degraded product or derivative thereof, lactoferrin or degraded product thereof, egg component, fish Examples include meat degradation products and nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid) and the like.

  Specific examples of components derived from microbial raw materials used as additives to the product of the present invention include yeast metabolites, yeast extract, bacterial metabolites, bacterial extract, metabolites such as mold or mushroom, actinomycetes metabolism Product, extract of mold or mushroom, actinomycetes extract, natto metabolite, natto extract, rice fermented extract, rice bran (red rice bran, white birch) fermented extract, euglena extract or decomposed product thereof or water-soluble derivatives thereof, Examples thereof include lactic acid fermented products of raw milk or skim milk powder.

  As the plant, animal, or microbial raw material, any site, cell, tissue, organ, metabolite, etc. derived from a transgenic or cell fusion can be used. Furthermore, it can be obtained by culturing cells of any site, cell, tissue, organ, etc., for example, cultured cells derived from each tissue (cultures derived from animals such as fibroblasts, Langerhans cells, macrophages, epidermal cells, hepatocytes, etc.) Cells, etc.), undifferentiated cells, cells in the middle of differentiation, metabolites thereof, and the like can also be used.

  Specific examples of the components of natural raw materials used as additives include seawater such as deep sea water, for example, sea salt, dried seawater, Dead Sea, Atlantic Ocean or Pacific Ocean. Potassium, etc.), sea mud or mud (Fango), for example, Italian mugo, German fungo, Eifelfango, Freiburg Fango, etc. Sea mud or mud (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, Manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, natural smectite , Bentonite, hectorite and the like.

  Extracts derived from plant raw materials, animal raw materials, microbial raw materials, and other natural product raw materials used as additives are processed in a conventional manner according to the product type and form to be added (for example, pulverization, milling, Treatment, extraction, decomposition, fermentation or metabolic conversion by microorganisms, fractionation, purification, pressing, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. ) And any one of various materials may be selected for use.

  The solvent used for the extraction may be selected in consideration of the intended purpose and type of the product to be provided, or the processing performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isopropanol are used. Lower alcohol such as butanol or hydrous lower alcohol, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1, 3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, 1,2-hexanediol, 1,5-hexanediol, 1,6-hexanediol, pentylene glycol, hexylene glycol, Polyhydric alcohols such as glycerin and polyethylene glycol (molecular weight 100 to 100,000) or hydrous polyhydric alcohols, alcohols , Ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, carbon tetrachloride, phenol, toluene, and other organic solvents, and acids prepared with appropriate normality (hydrochloric acid, sulfuric acid, It is desirable to use one or a mixture of two or more selected from nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.). However, when it is not preferable to contain a solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it may be used alone or in any mixture with water. It may be extracted after squeezing.

  Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. The temperature of the solvent can be arbitrarily set in the range of −4 ° C. to 100 ° C., but is preferably around 10 to 40 ° C. from the viewpoint of the stability of components contained in the raw material. Further, the weight ratio of the solvent to the raw material can be arbitrarily set within the range of, for example, raw material: solvent 4: 1 to 1: 100, and a weight ratio of 1: 1 to 1:10 is particularly preferable.

  Decomposition mainly includes acid decomposition, alkali decomposition, enzyme decomposition, and high-temperature and high-pressure decomposition. In the decomposition with an acid, for example, it is preferable to use an inorganic acid or an organic acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, oxalic acid, hydrogen bromide, perchloric acid, and periodic acid. In the decomposition by alkali, for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, barium hydroxide, sodium carbonate, ammonium carbonate, calcium carbonate, magnesium hydroxide, sodium silicate, etc. are preferably used. In the decomposition with acid or alkali, the concentration, reaction time, reaction temperature, and the like can be arbitrarily set for the target raw material. In the enzymatic degradation, it is preferable to use an enzyme having a function of degrading proteins, polysaccharides, lipids or complexes thereof having an important function particularly with respect to cell structure, tissue structure, etc., for example, aminopeptidase, dipeptidase, dipeptide Peptidyl peptidase, tripeptidyl peptidase, carboxypeptidase, serine protease, trypsin, chymotrypsin, cysteine protease, thiol protease, papain, aspartate endopeptidase, metalloendopeptidase, bromelain, thermolysin, pronase, pepsin, rennin, pan Proteolytic enzymes (proteases) such as creatine, chymopapain, ficin, collagenase, elastase, amylase, takaamylase, cellulase, hemicellular Polysaccharide-degrading enzymes such as pectinase, polygalacturonase, dextranase, planarase, chicken egg white lysozyme, human lysozyme, papaya lysozyme, turnip lysozyme, barley lysozyme, zymolyce, lysozyme chloride, glucanase, chitinase, etc. Cell wall lytic enzyme. In the degradation with an enzyme, the concentration, reaction time, reaction temperature, pH of the solution, etc. can be set arbitrarily, but it is particularly preferable to set the optimum value for the enzyme used.

  Fermentation or metabolic conversion by microorganisms can be performed by inoculating and growing at least one kind of microorganism on a raw material used as a substrate. Inoculation of microorganisms to the substrate can be done by adding microorganisms directly into the substrate, or by adsorbing them on a carrier such as alginic acid, polyvinyl, gelatin, etc., for example, in the form of fine beads composed of microorganisms and carrier. Further, it can be used by being fixed to the tube wall of the bioreactor. Fermentation or metabolic conversion by microorganisms is not particularly defined as a microorganism to be used, but can generally be defined as microorganisms other than pathogenic microorganisms that exhibit significant toxicity to living bodies. Examples of microorganisms to be used include microorganisms classified into yeasts: Aciculoconidium, Actonia, Aessosporon, Ambrosiozyma, Anthomyces, Apiotrichum, Arthroascus, Arxula, Ashbia, Ashbya, Asporomyces, Atelosaccharomyces Genus, Azymoprocandida, Babjevia, Ballistosporomyces, Bensingtonia, Blastobotrys, Blastodendrion, Blastoderma, Blastoschizomyces, Botryoascus, Botryozyma, Brettanomyces, Brettanomyces bruno, Cullus Genus (Candida albicans, Candida amylolenta, Candida anomala, Candida boidinii, Candida entomaea, Candida etchellsii, Candida famata, Candida fermentati, Candida guilliermondii, Candida halophila, Candida krusei, Candida krusei, Candida krusei, Candida krusei, Candida krusei Candida sake, Candida tropicalis, Candida versatilis, Candida vulgaris, etc.), Castellani Genus a, Chlamydozyma, Chromotorula, Citeromyces, Cladosporium, Clavispora, Crebrothecium, Cryptococcus, Debaryomyces (Debaryomyces delbrueckii, Debaryomyces halotolerans, Debaryomyces hansenii etc.), Deberoozyma, Debaryozyma, Dipodascus, Eeniella, Endomyces, Endomycopsis, Eremascus, Eremothecium, Eutorulopsis, Fabospora, Fellomyces, Filobasidium, Galactomyces, Geotrichoides, Geotrichum, Guilliermondella, anomala, Hansenula kluyveri, Hansenula miso, Hansenula polymorpha, Hansenula wickerhamii etc.), Hypomyces, Issatchenkia, Kloeckera (Kloeckera brevis, Kloeckera fluoresceny, Kloeckera Etc.), Kockovaella genus, Kurtzmanomyces genus, Leucosporidium genus, Lipomyces genus, Metschnikowia , Microanthomyces genus, Monilia genus, Monospora genus, Monosporella genus, Mrakia genus, Myceloblastanon genus, Mycocandida genus, Mycoderma genus, Mycotorula genus, Mycotoruloides genus, Myxozyma genus, Nadsonia sp Genus, Oospora, Oosporidium, Pachysolen, Parasaccharomyces, Paratorulopsis, Parendomyces, Petasopsora, Pichia (Pichia amylophila, Pichia farinosa, Pichia guilliermondii, Pichia membranifaciens, Pichia moc Genus, Proteomyces genus, Pseudomonilia genus, Pseudosaccharomyces genus, Pseudozyma genus, Rhodomyces genus, Rhodosporidium genus, Rhodotorula genus, Saccharomyces genus (Saccharomyces aceti, Saccharomyces cerasi, Saccharomyces cerevisiae Genus, Saturnispora, Schizoblastosporion, Schizosaccharomyces, Schwanniomyces Selenotila genus, Selenozyma genus, Smithiozyma genus, Sporidiobolus genus, Sporobolomyces genus, Sporothrix genus, Stephanoascus genus, Sterigmatomyces genus, Sympodiomyces genus, Symingospora genus, Tetrapisispora genus, Torulaspora genus, Tordenpostomy genus, Torulopsiron genus, Torulopsisces genus Genus William, genus Williamopsis, genus Wingea, genus Xanthophyllomyces, genus Yamadazyma, genus Zendera, genus Zygofabospora, genus Zygopichia, genus Zygosaccharomyces, genus Zymodebaryomyces and the like. The microorganisms classified as bacteria include the genus Acetobacter (Acetobacter aceti, etc.), Achromobacter genus, Acidianus genus, Acidobacterium genus, Acidithiobacillus genus, Acrocarpospora genus, Actinoalloteichus genus, Actinocorallia genus, Actinokineospora genus, Actinomadospura genus, Actinomadspura Actinosynnema genus, Aerococcus genus, Aeromicrobium genus, Agrobacterium genus, Agromyces genus, Ahrensia genus, Alcaligenes genus, Alicyclobacillus genus, Alloiococcus spp. Aureobacterium genus, Azotobacter genus, Bacillus genus (Bacillus brevis, Bacillus subtilis etc.), Bacteroides genus, Beneckea genus, Bifidobacterium genus (Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis etc.), Brachybacterium genus, Brevicillus genus, Brevicillus, Brevundimonas, Burkholderia, Carnobacterium, Catellatospora, Cellulomonas sp Enterobacter sp Genus, Halobacterium genus, Halococcus genus, Herbidospora genus, Hydrogenophilus genus, Hyphomicrobium genus, Hyphomonas genus, Intrasporangium genus, Janibacter genus, Kinesia spp. Kocuria, Kurthia, Lactobacillus (Lactobacillus rimae, Lactobacillus divergens, Lactob acillus carnis, Lactobacillus piscicola, Lactobacillus acidophilus, Lactobacillus amylophilus, Lactobacillus animalis, Lactobacillus brevis, Lactobacillus casei, Lactobacillus curvatus, Lactobacillus bulgaricus, Lactobacillus delbrueckii, Lactobacillus fermentum, Lactobacillus fructivorans, Lactobacillus fructosus, Lactobacillus helveticus, Lactobacillus hilgardii, Lactobacillus homohiochii, Lactobacillus kefiri , Lactobacillus malefermentans, Lactobacillus murinus, Lactobacillus paracasei, Lactobacillus paracasei subsp. tolerans, Lactobacillus parakefiri, Lactobacillus pentosus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus sakei, Lactobacillus confusus, Lactobacillus viridescens, Lactobacillus johnsonii, Lactobacillus viscosus, Lactobacillus fermentatae, Lactobacillus acidophil-aerogenes, Lactobacillus leichmannii, Lactobacillus gasseri, Lactobacillus bifidus, Lactobacillus jugurt, Lactobacillus caucasicus Lactobacillus arabinosus, Lactobacillus kunkeei, Lactobacillus nagelii, Lactobacillus fornicalis, Lactobacillus pentoaceticus, Lactobacillus xylosus, Lactobacillus minutus, etc.), Leuconostoc genus (Leuconostoc lactis, Leuconostoc dextranicum, Leuconostoc mesenteroides, Leuconostoc oenos, Leuconostoc paramesenteroides, Leuconostoc cremoris, such as Leuconostoc citrovorum), Listonella Genus, Lucibacterium genus, Luteococcus genus, Magnetospirillum genus, Marinilabilia genus, Marinospirillum genus Mesorhizobium genus, Metallosphaera genus, Methylobacterium genus, Microbispora genus, Micrococcus genus, Microellobosporia genus, Micromonospora genus, Mycobacterium genus, Nocoides genus, Noiaides Genus, Nonomuria, Oceanospirillum, Ochrobactrum, Oerskovia, Oligella, Paenibacillus, Pediococcus (Pediococcus cerevisiae, Pediococcus pentosaceus, Pediococcus urinae-equi etc.), Pedobacterto, Pedobacterto , Planobispora, Planococcus, Planomonospora, Prevotella, Propionibacterium, Proteus, Protomonas, Pseudomonas, Pseudonocardia, Rahnella, Rarobacter, Rathayibacter, Rhizobium, Rhizomonas , Rhodospirillum genus, Rothia genus, Rubrobacter genus, Ruegeria genus, Saccharomonospora genus, Saccharothrix genus, Serratia genus, Sinorhizobium genus, Sphingobacterium genus, Sphingomonas genus, Sporolactobacillus genus, Stenotrophomonas genus, Streptoalloteococ genus Streptoalloteococ faecium, Streptococcus bovis, Streptococcus equinus, Streptococcus mutans, Streptococcus salivarius, Streptococcus thermophilus, Streptococcus agalactiae, Streptococcus mitis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus lactisdy uberis, Streptococcus cremoris, Streptococcus diacetilactis, etc.), Streptomyces genus, Streptosporangium genus, Streptoverticillium genus, Terrabacter genus, Thermoactinomyces genus, Thermobifida genus, Thermobispora genus, Thermohispera genus, Thermohispa genus, Thermopispa genus, Thermopispa genus, Thermopispa genus Genus, Xanthobacter genus, Xanthomonas genus, Zymomonas genus and the like. Microorganisms classified as non-yeast ascomycetes, basidiomycetes or incomplete fungi include Allomyces, Amoebidium, Amorphotheca, Arthroderma, Ascoidea, Ascobolus, Ascodesmis, Aspergillus, Aureobasidium, Botryosphaeria Botryotinia sp Genus, Dothidea genus, Endogone genus, Entomophthora genus, Emericella genus, Eupenicillium genus, Eurotium genus, Exobasidium genus, Gibberella genus, Glomus genus, Graphiola genus, Gymnoascus genus, Harpella genus, Helicomyces genus, Helvella genus, Hemicarpenteles genus, Hyphochytrium genus, Hyphochytrium Hypocrea, Laboulbenia, Labyrinthula, Leptosphaeria, Leptosphaerulina, Lophodermium, Melanotaenium, Microascus, Microstroma, Medeololaria, Melampsora , Melamsporella, Morchella, Monascus, Monilinia, Mycospharella, Nannizzia, Nectria, Neolecta, Neurospora, Nodulosphaeria, Olpidium, Peziza, Penicillium, Perenospora, Pestopolisis Genus, Pneumocystis genus, Preussia genus, Pleospora genus, Puccinia genus, Pythium genus, Ravenelia genus, Rickia genus, Rhinocladiella genus, Rhizidiomyces genus, Rhizoctonia genus, Sclerocleista genus, Saprolegnia genus, Sclerotinia genus, Sclerotum genus, Septobasidium genus, Septobasidium genus Sporidiobolus genus, Stigmatomyces genus, Sydowiella genus, Talaromyces genus, Taphrina genus, Thraustochytrium genus, Tolyposporium genus, Trichoglossum genus, Trichoma genus, Ustilago genus, Verticillium genus, Xylaria genus and the like.

  In fermentation or metabolic conversion by microorganisms, in addition to various raw materials such as plant-based materials, animal-based materials, and other natural product-based materials, the growth and metabolism of microorganisms are regulated or activated, and special biosynthesis or degradation pathways are induced. In order to achieve this, various compounds can be added to the raw material. For example, as a carbon source, sugar, ethane such as glucose, fructose, galactose, sucrose, maltose, mannose, lactose, glycerin, starch, etc. , Hydrocarbons such as methane, propane, butane, formic acid, acetic acid, propionic acid, lauric acid, palmitic acid, fatty acids such as oleic acid, linoleic acid, linolenic acid, etc., nitrogen sources such as ammonium sulfate, ammonium hydrochloride, ammonium phosphate, etc. Ammonium salts, urea, uric acid, amino acids, etc. Vitamins and compounds containing potassium, calcium, magnesium, sodium, sulfur, phosphorus, chlorine, etc., as well as iron, copper, zinc, cobalt, nickel, boron, manganese, molybdenum, tin, selenium, silicon It is possible to further add compounds contained in the composition such as arsenic, vanadium, chromium and fluorine. In addition, the optimum temperature, oxygen supply amount, pH, pressure, etc. that affect the growth and metabolic activities of various microorganisms can be arbitrarily set according to the characteristics inherent to various microorganisms. Can be arbitrarily set within the range of 10 to 50 ° C., and the pH can be arbitrarily set within the range of 1 to 14.

  In fractionation or purification, generally known techniques can be used as appropriate. In addition to solvent extraction, for example, liquid chromatography (ion exchange chromatography, ion exclusion chromatography, affinity chromatography, gel filtration chromatography, size exclusion chromatography, etc.). Chromatography, hydrophilic adsorption chromatography, hydrophobic adsorption chromatography, ligand exchange chromatography, etc.) fractionation using a single column or multiple columns, dialysis with semipermeable membranes, crystallization and recrystallization of components. Examples thereof include crystallization, filter paper, membrane filter, ultrafilter, filtration using activated carbon, filter aid, etc., centrifugal separation and its application, fractional precipitation method, density gradient separation method such as density gradient sedimentation equilibrium method, and the like.

Specific examples of other components other than the above used as additives in the product of the present invention include silicic anhydride, magnesium silicate, talc, kaolin, bentonite, hectorite, natural or synthetic smectite, stevensite, mica, mica Inorganic such as titanium, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, bengara, black iron oxide, gunjo, chromium oxide, chromium hydroxide, carbon black, calamine Pigments, hydrogen peroxide, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, peroxide Sodium orthophosphate Sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide, etc. Reducing agents, redox agents such as thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate), 5-aminoorthocresol, 2-amino -4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, Toluene-2,5-diamine hydrochloride, nitroparaphenyle hydrochloride Diamine, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5- Dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium picrate, N N′-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, Metaphenylenediamine, 5-aminoorthocreso sulfate 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, Nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine, catechol, diphenylamine, α -Naturol, hydroquinone, phloroglucin, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sodium sulfonate, dyes such as hematein, natural materials such as musk, civet, castrium, ambergris Animal flavors, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam Essential oil, Koreanel essential oil, Perilla essential oil, Cedarwood essential oil, Citronella essential oil, Jasmine essential oil, Gingergrass essential oil, Cedar essential oil, Spearmint essential oil, Western peppermint essential oil, Otsuka perfume essential oil, Cube rose essential oil, Clove essential oil, Orange flower essential oil, Winter green essential oil, Truval Sam Essential Oil, Baturi Essential Oil, Rose Essential Oil, Palmarosa Essential Oil, Crude Essential Oil, Hiba Essential Oil, Sandalwood Essential Oil, Petit Glen Essential Oil, Bay Essential Oil, Bechiba Essential Oil, Bergamot Essential Oil, Peruvian Sam Essential Oil, Boadrose Essential Oil, Mango Essential Oil, Mandarin Essential Oil, Eucalyptus Essential Oil Lime essential oil, lavender essential oil, Linaroe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, vegetable flavors such as Japanese mint essential oil, other synthetic flavors, 5-amino-o-cresol, o-aminophenol, m-aminophenol, p-aminophenol, 2,6-diaminopyridine, 5- (2-hydroxylethylamino) -2-methylphenol, N, N-bis (β-hydroxyl) -p-phenylenediamine sulfate, N, N-bis (2-hydroxyethyl) -p-phenylenediamine, p-nitro-o-phenylenediamine, p-phenylenediamine, m-phenylenediamine, N-phenyl-p-phenylenediamine, 2-hydroxy-5 -Nitro-2 ', 4'-diaminoazobenzenesodium sulfate, toluene-2,5-diamine, 2- (2'-hydroxyethylamino) -5-aminotoluene, N, N-bis (β-hydroxyl) -p -Phenylenediamine, N, N- Bis (2-hydroxyethyl) -p-phenylenediamine sulfate, 5-amino-o-cresol sulfate, p-aminophenol sulfate, o-chloro-p-phenylenediamine sulfate, 2- (2'-hydroxy Ethylamino) -5-aminotoluene sulfate, 4,4'-diaminodiphenylamine sulfate, p-methylaminophenol sulfate, p-phenylenediamine sulfate, m-phenylenediamine sulfate, toluene-2,5-diamine Sulfate, 2,4-diaminophenoxyethanol hydrochloride, toluene-2,5-diamine hydrochloride, m-phenylenediamine hydrochloride, 2,4-diaminophenol hydrochloride, 3,3'-iminodiphenol, p-phenylene Diamine hydrochloride, N-phenyl-p-phenylenediamine hydrochloride, N-phenyl-p-phenylenediamine acetate, 1,5-dihydroxynaphthalene, toluene-3,4-diamine, p-methylaminophenol, N, N '-Screw( 4-aminophenyl) -2,5-diamino-1,4-quinonediimine, o-aminophenol sulfate, 2,4-diaminophenol sulfate, m-aminophenol sulfate, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, nitro-p-phenylenediamine hydrochloride, 1,4-diaminoanthraquinone, nitro-p-phenylenediamine, picramic acid, sodium picramate, 2 -Amino-5-nitrophenol sulfate, resorcinol, nitro-p-phenylenediamine sulfate, p-nitro-o-phenylenediamine sulfate, p-nitro-m-phenylenediamine sulfate, red No. 2, red No. 3 Red No. 102, Red No. 104 (1), Red No. 105 (1), Red No. 106, Red No. 201, Red No. 227, Red No. 230 (1), Red No. 230 (2), Red 231 、 Red 232 、 Red 401 、 Red 502 、 Red 503 、 Red 5 04, Red 506, Yellow 4, Yellow 5, Yellow 202 (1), Yellow 202 (2), Yellow 203, Yellow 402, Yellow 403 (1), Yellow 406 Yellow 407, Orange 205, Orange 207, Orange 402, Green 3, Green 204, Green 205, Green 401, Green 402, Brown 402, Purple 201, Purple 401, Blue 1, Blue No. 2, Blue No. 202, Blue No. 203, Blue No. 205, Black No. 401, Red Cabbage Dye, Sockeye Dye, Catechol Tannin, Red Rice Dye, Akane Dye, Anato Dye, Ikumi Dye, Turmeric Dye, Enju Dye, Krill Dye, Amber dye, Caramel, Gold, Silver, Gardenia dye, Corn dye, Onion dye, Tamarind dye, Spirulina dye, Cherry dye, Nori dye, Hibiscus dye, Grape juice dye, Grape peel dye, Marigold dye, Purple potato dye , Purple yam pigment, lac pigment, rutin and other pigments / colorants, avo Gado oil, almond oil, fennel oil, egoma oil, olive oil, orange oil, orange rafa oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, kukui nut oil, safflower oil, shea fat, liquid shea Fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, coconut oil, beef tallow, lard Or oils and fats such as hydrogenated products (hardened oil, etc.), beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax, squalene, squalane, pristane Waxes, liquid paraffin, petrolatum, paraffin, ozokerai , Mineral oils such as ceresin and microcristan wax, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid , Natural fatty acids such as tall oil, lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid, fatty acids such as synthetic fatty acids such as isopentanoic acid, ethanol, Natural alcohols such as isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, 2-hexyldecanol, isostearyl alcohol, 2-octane Alcohols such as synthetic alcohols such as ludodecanol, isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, adipine Diisobutyl acid, 2-hexyldecyl adipate, diheptylundecyl adipate, N-alkyl glycol monoisostearate, isocetyl isostearate, trimethylolpropane triisostearate, ethylene glycol diethyl hexanoate, neopentyl glycol diethyl hexanoate, 2- Cetyl ethylhexanoate, trimethylolpropane triethylhexanoate, pentaerythritol tetraethylhexanoate, octane Cetyl acid, octyldodecyl gum, cetyl lactate, myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, aluminum stearate, stearin Metal soaps such as magnesium oxide, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate, anionic surfactants (alkyl carboxylates, alkylsulfonates, alkyl sulfates) Alkyl phosphate ester salt), alkyl sulfate ester salt (sodium lauryl sulfate, potassium lauryl sulfate, triethanolamine lauryl sulfate, ammonium lauryl sulfate, Sodium til sulfate, sodium stearyl sulfate, etc., secondary alcohol sulfate, alkyl ether sulfate (for example, polyoxyethylene lauryl sulfate triethanolamine, polyoxyethylene lauryl sodium sulfate, etc.), alkyl and alkyl allyl ether sulfates Salt (N-acyl methyl alanine salt, N-acyl glutamate, N-acyl methyl taurate, N-acyl isethionate, N-acyl glycine salt, alkyl phosphate, alkyl ether carboxylate, alkyl sulfonate, Alkylsulfosuccinate, sodium polyoxyethylene lauryl ether sulfate, polyoxyethylene lauryl ether sulfate triethanolamine, polyoxyethylene lauryl ether ammonium sulfate, polyoxyethylene alkyl ether -Sodium sulfate, polyoxyethylene alkyl ether sulfate triethanolamine, polyoxyethylene alkyl ether sulfate diethanolamine, polyoxyethylene alkyl ether ammonium sulfate, etc.), higher fatty acid alkylolamide sulfate, higher fatty acid ester sulfate (cured coconut oil) Fatty acid sodium glycerine sulfate, etc.), polyoxyethylene alkyl ether carboxylic acid, polyoxyethylene alkyl allyl ether carboxylate, sulfated oil such as sulfated castor oil, mono or dialkyl or alkenyl phosphate ester salt, polyoxyethylene mono or Dialkyl or alkenyl phosphate ester salts (sodium monolauryl phosphate, sodium isostearyl phosphate, arginine 2-hexyldecyl phosphate, 2-heptyl Potassium Ndeshirurin acid, polyoxyethylene (4-10
) Sodium lauryl ether phosphate, sodium monocetyl phosphate, arginine monomyristyl phosphate, sodium monooleyl phosphate, polyoxyethylene (2-10) potassium lauryl ether phosphate, sodium dioctyl phosphate, etc.), polyoxyethylene alkyl ether Phosphate ester salts (polyoxyethylene lauryl ether phosphate, polyoxyethylene oleyl ether phosphate, polyoxyethylene cetyl ether phosphate, polyoxyethylene stearyl ether phosphate, polyoxyethylene alkyl ether phosphate, polyoxyethylene alkylphenyl Ether phosphates), higher fatty acid amide sulfonates or higher fatty acid ester sulfonates (α-olefin sulfonate, N-myristoyl-N-methyltaurine sodium, palm Fatty acid methyl taurine sodium, lauroyl methyl taurine sodium, etc.), alkyl benzene sulfonate (dodecyl benzene sulfonic acid, dodecyl benzene sulfonic acid monoethanol amine, dodecyl benzene sulfonic acid diethanol amine, dodecyl benzene sulfonic acid triethanol amine, dodecyl benzene sulfonic acid sodium salt, etc. ), Sulfosuccinate (sodium diethylhexylsulfosuccinate, sodium sulfosuccinate, disodium lauryl sulfosuccinate, disodium polyoxyethylene sulfosuccinate, disodium lauryl polyoxyethylene sulfosuccinate, disodium polyoxyethylene lauroyl ethanolamide ester sulfosuccinate , Undecylenoylamidoethylsulfosuccinate Monolauroyl monoethanolamide polyoxyethylene sodium sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc.), N-acyl sarcosine salts (eg lauroyl sarcosine sodium, palmitoyl sarcosine sodium), condensates of higher fatty acids and amino acids (N-acyl glutamate) , Sodium N-stearoyl glutamate, potassium N-palmitoyl glutamate, sodium N-lauroyl-L-glutamate, disodium N-stearoyl-L-glutamate, sodium N-myristoyl-L-glutamate, sodium myristoyl methyl taurate, sodium palmitoyl methyl taurate , Sodium stearoylmethyl taurine, N-palmitoyl-β-alanine arginine, N-palmitoyl aspartate ditriethanol Anionic surfactants such as fatty acid soaps such as oleate, suarenate, laurate and palmitate (examples of anionic surfactant salts include alkali salts such as sodium salt and potassium salt). Metal salts, monoethanolamine salts, diethanolamine salts, triethanolamine salts, L-lysine salts, organic ammonium salts such as L-arginine salts, ammonium salts, etc.), quaternary ammonium salts (alkyltrimethylammonium chloride, Cetyl ammonium chloride, cetyl ammonium bromide, lauryl ammonium chloride, lauryl ammonium bromide, stearyl ammonium chloride, stearyl ammonium bromide, cetyl dimethyl ammonium chloride, cetyl dimethyl ammonium bromide, lauryl dimethyl ammonium chloride, stearyl dichloride Tyl ammonium, lauryl trimethyl ammonium chloride, lauryl trimethyl ammonium bromide, stearyl dimethyl cetyl ditallow dimethyl ammonium chloride, dicetyl ammonium chloride, dicetyl ammonium bromide, dilauryl ammonium chloride, dilauryl ammonium bromide, distearyl ammonium chloride, Distearylammonium bromide, dicetylmethylammonium chloride, dicetylmethylammonium bromide, dilaurylmethylammonium chloride, dilaurylmethylammonium bromide, distearylmethylammonium chloride, distearylmethylammonium bromide, cetyltrimethylammonium chloride, Cetyltrimethylammonium bromide, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, Lauryltrimethylammonium chloride, dialkyldimethylammonium chloride, dicetyldimethylammonium chloride, distearyldimethylammonium chloride, dicocoyldimethylammonium chloride, myristyldimethylbenzylammonium chloride, stearyldimethylbenzylammonium chloride, lanolin fatty acid ethylpropylethyldimethylammonium chloride, Cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, behenyltrimethylammonium chloride, behenyldimethylhydroxyethylammonium chloride, stearyldimethylbenzylammonium chloride, distearyldimethylammonium chloride, distearoylethylhydroxyethylmonium metasulfate, dicocoylethylhydroxyethyl Monium metasulfate, dipalmitoylethylhydroxyethylmonium metasulfate, and cetyltriethylammonium methyl sulfate, alkyltrimethylammonium chloride, alkyldimethylbenzylammonium chloride, dialkyldimethylammonium chloride, alkyltrimethylammonium bromide, alkylpentaethoxyammonium chloride, ditallow Dimethyl ammonium chloride, ditallow dimethyl ammonium methyl sulfate, ditallow dipropyl ammonium phosphate, ditallow dimethyl ammonium nitrate, di (coconut alkyl) dimethyl ammonium chloride, di (coconut alkyl) dimethyl ammonium bromide, coconut ammonium chloride, stearamide propyl PG-dimonium chloride chloride, steal Amidopropyl ethyl dimonium esosulphate, stearamide propyl dimethyl (myristyl acetate) ammonium chloride, stearamide propyl dimethyl cetearyl ammonium tosylate, stearamide propyl dimethyl ammonium chloride, stearamide propyl dimethyl ammonium lactate, ethyl lanolin sulfate Fatty acid aminopropylethyldimethylammonium, cationized cellulose, acyldiethylaminoethylamide, acyldimethylaminopropylamide, polyoxyethylene fatty acid amide, myristyldimethylamine oxide, N-lauryldimethylaminoacetic acid betaine, N-myristyldimethylaminoacetic acid betaine, N -Stearyldimethylaminoacetic acid betaine), bis fatty acid ester salts (hydroxypropyl-bis-ra) Amidopropyl phosphate-N, N-dimethylammonium chloride, hydroxypropyl-bis-myristate amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-palmitate amidopropyl-N, N-dimethylammonium chloride, hydroxy Propyl-bis-stearic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-behenic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-oleic acid amidopropyl-N, N-dimethyl Ammonium chloride, hydroxypropyl-bis-isostearic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-biphenyl -Palm fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-tallow fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-lauric acid amidoethyl-N, N-diethylammonium chloride, hydroxy Propyl-bis-myristate amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palmitamidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-amidoethyl stearate-N, N-diethylammonium chloride, Hydroxypropyl-bis-behenic acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-oleic acid amidoethylammonium chloride, hydroxypropyl-bis-isostearic acid Ethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-tallow Fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-lauric acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-myristic amidopropyl-N, N-diethylammonium chloride, hydroxypropyl- Bis-palmitic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-stearic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-behenic acid amidopropi -N, N-diethylammonium chloride, hydroxypropyl-bis-oleic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-isostearic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis -Palm fatty acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-tallow fatty acid amidopropyl-N, N-diethylammonium chloride, etc. ), Stearamidopropyl PG-dimonium chloride phosphate, behenamidopropyl PG dimonium chloride, stearamidopropylethyldimonium ethosulphate, stearamidopropyldimethyl (myristyl acetate) chloride Cationic surfactants such as monium, stearamidepropyldimethylcetearylammonium tosylate, stearamidepropyldimethylammonium chloride, stearamidepropyldimethylammonium lactate, glycerin fatty acid esters (glyceryl monoundecylenate, glyceryl diundecylenate) Glyceryl monomyristate, glyceryl dimyristate, glyceryl monopalmitate, glyceryl dipalmitate, glyceryl monostearate, glyceryl distearate, glyceryl monooleate, mono cottonseed oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, mono Glyceryl stearate, α, α'-oleic acid pyroglutamate glycerin, monostearate glycerin malate, etc.), polyglycol Phosphorus fatty acid esters (diglyceryl monomyristate, diglyceryl dimyristate, diglyceryl trimyristate, diglyceryl monopalmitate, diglyceryl dipalmitate, diglyceryl tripalmitate, diglyceryl monostearate, diglyceryl distearate Diglyceryl tristearate, diglyceryl monooleate, diglyceryl dioleate, diglyceryl trioleate, tetraglyceryl monopalmitate, tetraglyceryl dipalmitate, tetraglyceryl tripalmitate, tetraglyceryl tetrapalmitate, pentapalmitin Tetraglyceryl acid, tetraglyceryl monostearate, tetraglyceryl distearate, tetraglyceryl tristearate, tetraglyceryl tetrastearate Rilyl, tetraglyceryl pentastearate, tetraglyceryl monooleate, tetraglyceryl dioleate, tetraglyceryl trioleate, tetraglyceryl tetraoleate, tetraglyceryl pentaoleate, hexaglyceryl monopalmitate, hexaglyceryl dipalmitate, tri Hexaglyceryl palmitate, hexaglyceryl tetrapalmitate, hexaglyceryl pentapalmitate, hexaglyceryl monostearate, hexaglyceryl distearate, hexaglyceryl tristearate, hexaglyceryl tetrastearate, hexaglyceryl pentastearate, hexaoleate monooleate Glyceryl, dioleic acid hexaglyceryl, trioleic acid hexaglyceryl, tetraoleic acid hexag Lyseryl, hexaglyceryl pentaoleate, decaglyceryl monopalmitate, decaglyceryl dipalmitate, decaglyceryl tripalmitate,
Decaglyceryl trapalmitate, decaglyceryl pentapalmitate, decaglyceryl hexapalmitate, decaglyceryl heptapalmitate, decaglyceryl octapalmitate, decaglyceryl nonapalmitate, decaglyceryl monostearate, decaglyceryl monostearate, distearic acid Decaglyceryl, decaglyceryl tristearate, decaglyceryl tetrastearate, decaglyceryl pentastearate, decaglyceryl hexastearate, decaglyceryl heptearate, decaglyceryl octastearate, decaglyceryl nonostearate, decaglyceryl decastearate , Decaglyceryl monooleate, decaglyceryl dioleate, decaglyceryl trioleate, tetraoleate Glyceryl, decaglyceryl pentaoleate, decaglyceryl hexaoleate, decaglyceryl heptaoleate, decaglyceryl octaoleate, decaglyceryl nonaoleate, decaglyceryl monohydroxystearate, decaglyceryl dihydroxystearate, decaglyceryl dihydroxystearate, tri Decaglyceryl hydroxystearate, decaglyceryl tetrahydroxystearate, decaglyceryl pentahydroxystearate, decaglyceryl hexahydroxystearate, decaglyceryl heptahydroxystearate, decaglyceryl octahydroxystearate, decaglyceryl nonahydroxystearate, decahydroxyl Decaglyceryl stearate, hexaglyceryl polyricinoleate, poly Decaglyceryl ricinoleate, polyoxyethylene glyceryl monostearate, polyoxyethylene glyceryl distearate, polyoxyethylene glyceryl monooleate, polyoxyethylene glyceryl monomyristic acid), polyoxyethylene glyceryl fatty acid ester (polyoxyethylene glyceryl monoester) Stearate, polyoxyethylene glycerol monoisostearate, polyoxyethylene glycerol triisostearate, etc.), sorbitan fatty acid ester (sorbitan monolaurate, sorbitan monooleate, sorbitan sesquioleate, sorbitan trioleate, sorbitan monopalmitate) Sorbitan monostearate, sorbitan distearate, sorbitan dioleate, sorbitan monopalmitate Sorbitan tristearate, sorbitan trioleate, diglycerin sorbitan penta-2-ethylhexylate, diglycerin sorbitan tetra-2-ethylhexylate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polypalmitate monopalmitate Oxyethylene sorbitan, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan trioleate, polyoxyethylene sorbitan pentaoleate, propylene glycol fatty acid ester (propylene glycol monooctanoate, propylene glycol monodecanoate, propylene glycol monostearate) ), Sucrose fatty acid ester (monolauric acid sucrose ester, dilauric acid sucrose ester, monopalmitic acid Sugar ester, dipalmitic acid sucrose ester, monostearic acid sucrose ester, distearic acid sucrose ester, etc.), dextrin fatty acid ester (such as dextrin palmitate), palm oil fatty acid alkanolamide, polyoxyethylene castor oil, polyoxyethylene Hydrogenated castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, polyoxyethylene hydrogenated castor oil maleic acid, poly Oxyethylene alkyl ether (alkyl polyglucoside, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene behenyl ether, polyoxyethylene Oleyl ether, polyoxyethylene lauryl ether, polyoxyethylene-2-octyldodecyl ether, polyoxyethylene cholestanol ether, etc.), polyoxyethylene alkylphenyl ether (polyoxyethylene nonylphenyl ether, polyoxyethylene octylphenyl ether, etc.) , Polyoxyethylene fatty acid esters (polyethylene glycol monooleate, polyethylene glycol monostearate, polyethylene glycol monolaurate, etc.), lanolin derivatives (polyoxyethylene lanolin, polyoxyethylene lanolin alcohol, polyoxyethylene sorbitol lanolin, etc.), POE POP-alkyl ether (POE / POP-cetyl ether, POE / POP-2-decyltetradecyl ether, POE / POP-monobutyl ether, POE / POP- Nonionic surfactants such as hydrogenated lanolin, POE / POP-glycerin ether, tetronic, etc.), alkanolamides (coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.), betaine-type amphoteric surface activity Agents (2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, undecylcarboxymethoxyethylcarboxymethylimidazolinium betaine sodium, undecylhydroxyethylimidazolinium betaine sodium, undecyl -N-hydroxyethyl-N-carboxymethylimidazolinium betaine, alkyldiaminoethylglycine hydrochloride, stearyl dihydroxyethyl betaine, stearyldimethylaminoacetic acid betaine, Sodium allyldimethylbetaine solution, coconut oil alkyl-N-carboxyethyl-N-hydroxyethylimidazolinium betaine sodium, coconut oil alkylbetaine, coconut oil alkyldimethylaminoacetic acid betaine, coconut oil fatty acid amidopropyl betaine, coconut oil fatty acid-N -Carboxymethoxyethyl-N-carboxyethylimidazolinium betaine sodium, N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, N-cocoyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium , Lauryldimethylaminoacetic acid hydroxysulfobetaine, coconut oil alkyldimethylaminoacetic acid hydroxysulfobetaine, laurylaminopropionic acid triethanolamine, β-laurylaminopropionic acid sodium, Amidopropyl dimethylaminoacetic acid betaine urylate, Amidopropyl dimethylaminoacetic acid hydroxysulfobetaine, Fatty acid amidopropyldimethylaminoacetic acid hydroxysulfobetaine, Palm oil fatty acid amidopropyldimethylaminoacetic acid hydroxysulfobetaine, Palm oil fatty acid amidopropyldimethyl Aminoacetic acid betaine, palm oil fatty acid amidopropyldimethylaminoacetic acid betaine, lauryl-N-carboxymethoxyethyl-N-carboxymethylimidazolinium disodium dodecanoyl sarcosine, sodium lauryldiaminoethylglycine, lauric acid amidopropyl betaine solution, lauryl sulfo Betaine, laurylhydroxysulfobetaine, 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimida Linium betaine, cocodimethylcarboxymethylbetaine, lauryldimethylcarboxymethylbetaine, lauryldimethylalphacarboxyethylbetaine, cetyldimethylcarboxymethylbetaine, cetyldimethylbetaine, laurylbis- (2-hydroxyethyl) carboxymethylbetaine, stearylbis- (2 -Hydroxypropyl) carboxymethylbetaine, oleyldimethylgamma-carboxypropylbetaine, laurylbis- (2-hydroxypropyl) alpha-carboxyethylbetaine, cocodimethylsulfopropylbetaine, stearyldimethylsulfopropylbetaine, lauryldimethylsulfoethylbetaine, laurylbis- (2-Hydroxyethyl) sulfopropyl betaine, Levon 2000 (Sanyo Chemical Co., Ltd.), palm oil fatty acid amid Lopyldimethylbetaine, palm oil fatty acid amidopropylsulfobetaine, imidazolinium-type amphoteric surfactant (bis (stearyl-N-hydroxyethylimidazoline) chloroacetic acid complex, N-alkyl-N-carboxymethyl-N-hydroxyethyl Imidazolinium betaine, N-alkyl-N-carboxymethyl-N-hydroxyethylethylenediamine lauryl sulfate and its salts, coconut oil alkyl-N-carboxyethoxyethyl-N-carboxyethylimidazolinium disodium hydroxide, coconut oil Alkyl-N-carboxymethoxyethyl-N-carboxyethylimidazolinium disodium hydroxide, palm oil alkyl-N-carboxymethoxyethyl-N-carboxyethylimidazolinium disodium lauryl sulfate, 2-undecyl-N, N, N- (hydroxyethylcarboxy Til) -2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, ovazoline 662 (Toho Chemical Co., Ltd.), Swanol AM-101 (Nikko Chemicals Co., Ltd.), aminopropion Acidic amphoteric surfactant (alkylaminopropionic acid such as sodium dodecylaminopropionate, alkylaminodipropionic acid, etc.), sodium dodecylaminopropanesulfonate, N-higher alkylaspartic acid or its salt, coamidopropyl chlorinated polyethylene glycol Dimonium phosphate, cocamidopropylhydroxysultain, sodium lauroyl sarcosinate, alkylamine oxide (decylamine oxide, cocoamine oxide, myristoylamine oxide, palmitoylamine oxide, alkyldimethylamine Amphoteric surfactants such as oxide and alkylamidopropylamine oxide), natural surfactants (lecithin, sodium caseinate, sphingolipid, saponin, mannosyl polyhydric alcohol fatty acid ester, glucosyl polyhydric alcohol fatty acid ester, galactosyl polyhydric alcohol) Monosaccharide polyhydric alcohol fatty acid esters such as fatty acid esters or disaccharide polyhydric alcohol fatty acid esters, oligosaccharide polyhydric alcohol fatty acid esters, etc.) and amino acid surfactants (capric acid chloride, lauric acid chloride, myristic acid chloride, palmitic acid) Fatty acid chloride such as chloride, stearic acid chloride, oleic acid chloride, behenic acid chloride, coconut oil fatty acid chloride and glycine, sarcosine, β-alanine, N-methyl-β-alanine, taurine, (Reactants with amino acids in a broad sense such as N-methyltaurine), silicone surfactant (silicon KF-6011 (manufactured by Shin-Etsu Chemical Co., Ltd.), KF-6012 (manufactured by Shin-Etsu Chemical Co., Ltd.), KF-6013 (Shin-Etsu Chemical KF-6015 (Shin-Etsu Chemical Co., Ltd.), KF-6016 (Shin-Etsu Chemical Co., Ltd.), KF-6017 (Shin-Etsu Chemical Co., Ltd.), X-22-4991 (Shin-Etsu Chemical Co., Ltd.) , NUC silicon L7002 (manufactured by Nihon Unicar), SH-3772C (manufactured by Toray Dow Corning Silicone), SH-3775C (manufactured by Toray Dow Corning Silicone), and other polyoxyalkylene-modified organopolysiloxanes, ABIL EM-90 ( Gold Schmidt), ABIL B9806 (Gold Schmidt), Silicon KF-6026 (Shin-Etsu Chemical Co., Ltd.) and other long-chain alkyl-containing polyoxyalkylene-modified organopolysiloxanes), polyether-modified silicone (polyoxyethylene)・ Methylpolysiloxane copolymer, poly (oxye (Lenoxypropylene) methylpolysiloxane copolymer, etc.), oxazoline-modified organopolysiloxane, alkyl-modified organopolysiloxane, styryl ketone silicone derivatives, dimethylpolysiloxane, methylphenylpolysiloxane, epoxy-modified silicone, fluorine-modified silicone, alcohol-modified Silicone, alkyl-modified silicone, alkoxy-modified silicone, amino-modified silicone, ammonium-modified polymer silicone, organopolysiloxane, methylphenylpolysiloxane, polysiloxane, poly (N-acylalkyleneimine) -modified silicone, dimethylpolysiloxane, nitrogen-containing acrylic -Silicone graft copolymer, decamethylcyclopentasiloxane, fluorine-substituted alkyl-modified silicone, organopoly Loki Sa alkenyl silyl alkyl-modified silicone, tricyclic Jiteru Bae Nkarubon acid-modified silicone, trifluoroalkyl modified
Ricone, divinylpolydimethylsiloxane, dihydrogenpolydimethylsiloxane, dihydrogenpolydimethylsiloxane divinylpolydimethylsiloxane polymer, trimethylsiloxysilicic acid, polyoxypropylene / methylpolysiloxane copolymer, ethylpolysiloxane, ethylmethylpolysiloxane, Ethylphenyl polysiloxane, octamethylcyclotetrasiloxane, diorganopolysiloxane, octamethylcyclotetrasiloxane, tetramethyltetraphenyltetracyclosiloxane, polyether modified polysiloxane, amino modified polysiloxane, epoxy modified polysiloxane, fluorine modified poly Siloxane, alcohol-modified polysiloxane, alkyl-modified polysiloxane, dodecamethylcyclohexasiloxane, laur Lumethicone copolyol, aminoethylaminopropylsiloxane / dimethylsiloxane copolymer, silicone compounds such as eugenol-modified silicone, selenium disulfide, alkylisoquinolinium bromide, zinc pyrithione, biphenamine, thianthol, quinine hydrochloride, strong ammonia water And the like.

  Others, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, refreshing agents, stabilizers, emulsifiers, animal / plant proteins and their degradation products, animal / plant polysaccharides and their Degradation products, animal / plant glycoproteins and their degradation products, anti-inflammatory agents, antiallergic agents, wound treatment agents, foaming agents, thickeners, enzymes, purified water (electronic water, small clustering, etc.), deodorant / A deodorant etc. can be used in combination.

  Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

[Production Example 1] Encapsulating micelle of ascorbic acid tetraisopalmitate with block copolymer As a block copolymer, a polyethylene glycol-poly (γ-benzyl-L-glutamic acid) block copolymer (polyethylene glycol molecular weight 10,000, glutamic acid polymerization degree 40) is basically used. And the proportion of the benzyl group which is a group other than a hydrogen atom in R ⁵ in the formula is 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% And each block copolymer that was 100% was used.
Weigh 2 g of block copolymer into a screw tube, add 200 mL of purified water, pulverize using a wet pulverizer (Nao-Mizer MkII, manufactured by Yoshida Kikai Kogyo Co., Ltd.), sonicate, and then add 0.2 mL of ethanol. Polymeric micelles containing ascorbic acid tetraisopalmitate were prepared by adding the entire amount of 0.02 g of dissolved ascorbic acid tetraisopalmitate and stirring. The particle size of the prepared polymer micelle was measured using a laser diffraction / scattering particle size distribution analyzer (LS Particle Size Analyzer, manufactured by BECKMAN COULTER). The results are shown in Table 1.

  As shown in Table 1, polymer micelles could be formed with a copolymer in which the proportion of benzyl groups in the block copolymer was 40 to 100%. The particle size was in the range of 60 to 600 nm. On the other hand, when the proportion of benzyl groups in the block copolymer is 10 to 30%, micelles are not formed, and it has been proved unsuitable for the present invention.

[Test Example 1] Sustained release of ascorbic acid tetraisopalmitate-encapsulated polymer micelle from Production Example 1 Ascorbic acid tetraisopalmitate-encapsulated polymer micelle obtained in Production Example 1 was used as a block copolymer. Those having a benzyl group content of 40%, 50%, and 100% were tested.
The micelles were disrupted by adding 0.1 g of ascorbic acid tetraisopalmitate-encapsulating polymer micelles to 10 mL of 50% acetonitrile aqueous solution. Then, the amount of tetraisopalmitate ascorbate contained in the solution was quantified using a vitamin C measurement kit (Japan Aging Control Research Laboratories), and the amount of tetraisopalmitate contained in 0.1 g of polymer micelle was determined. It was measured.
Next, 0.1 g of the polymer micelle of Production Example 1 is added to 70 mL physiological saline (200 mL beaker) which is a solution in which the sustained release of the encapsulated substance is confirmed, and 30 mL of 1,3-butylene glycol is added thereto. The micelles were uniformly dispersed by sufficiently stirring. Next, the dispersion solution was allowed to stand for 12 hours in an environment at room temperature. Next, polymer micelles were removed from the dispersion, and the amount of ascorbic acid tetraisopalmitate that was slowly released in the obtained solvent was quantified using a vitamin C measurement kit in the same manner as described above. As a control, the same operation was performed using a system to which 1,3-butylene glycol was not added, and the amount of ascorbic acid tetraisopalmitate released in the solvent was measured. From these measured values, the sustained release rate (%) out of micelles in the total amount of tetraisopalmitate contained in ascorbic acid was calculated. The results are shown in Table 2.

[Results of Test Example 1]
As shown in Table 2, the polymer micelle encapsulating tetraisopalmitate ascorbic acid, which is the hydrophobic substance of the present invention, and 1,3-butylene glycol coexist in the form of a solution, so that the encapsulated substance is marked. Improvement in sustained release was confirmed. In particular, in a polymer micelle produced using a copolymer having a high occupancy ratio of benzyl groups in the copolymer, strong loading of a hydrophobic substance was confirmed in a system in which 1,3-butylene glycol was not added. 1,3-butylene glycol was added, and particularly significant sustained release was confirmed.

(Manufacturing examples of various preparations)
Various dosage forms according to the present invention were prepared. Although the formulation example is shown below, this invention is not necessarily limited to these.

(Formulation example 1) Polymer micelle (alpha-tocopherol inclusion) of emulsion production example 1 4.0 mass%
Squalane 5.0% by mass
Olive oil 5.0% by mass
Jojoba oil 5.0% by mass
Cetanol 1.5% by mass
Glycerin monostearate 2.0% by mass
Polyoxyethylene (20) cetyl ether 3.0% by mass
Polyoxyethylene (20) sorbitan monooleate 2.0% by mass
1,3-Putylene glycol 1.0% by mass
Glycerin 2.0% by mass
Sodium malate 1.0 mass%
Paraben Appropriate amount of perfume Appropriate amount of purified water Residual

(Formulation example 2) Polymer micelle 2.5% by mass of lotion production example 1
(Ascorbic acid tetraisopalmitate inclusion)
Oolong tea extract 1.0% by mass
Dipropylene glycol 5.0% by mass
Rafuinose 1.0% by mass
Ethanol 5.0% by mass
Phenoxyethanol 0.2% by mass
Pectin 0.01% by mass
Xanthan gum 0.05% by mass
Acetylglucosamine 0.05% by mass
Diisopropylamine dichloroacetic acid 0.2% by mass
γ-amino-β-hydroxybutyric acid 0.2% by mass
Sodium hyaluronate 0.001% by mass
Allantoin 0.1% by mass
N-methylglyceryl ether 0.2% by mass
Ascorbic acid-2-glucoside 0.2% by mass
Dipotassium glycyrrhizinate 0.2% by mass
Decarpoxycarnosine hydrochloride 0.05% by mass
Perfume Appropriate amount of purified water

(Formulation example 3) Polymer micelle (alpha-tocopherol inclusion) of cloudy lotion production example 1 1.0 mass%
Dipotassium glycyrrhizinate 0.2% by mass
Citric acid 0.01% by mass
Sodium citrate 0.05% by mass
Tetraoleic acid POE (60) sorbitol 0.9% by mass
Sorbitan monooleate 0.1% by mass
Olive oil 0.1% by mass
Dipropylene glycol 5.0% by mass
Ethanol 10.0% by mass
Purified water residue

(Formulation Example 4) Gel beauty serum xanthan gum 0.4% by mass
Hydroxyethyl cellulose 0.1% by mass
Carboxyvinyl polymer 0.1% by mass
Polymer micelle of Production Example 1 2.0% by mass
(Ascorbic acid tetraisopalmitate inclusion)
1,3-butylene glycol 5.0% by mass
Potassium hydroxide 0.025 mass%
Preservative appropriate amount ethanol 3.0% by mass
Purified water residue

(Formulation example 5) Polymer micelle (ceramide inclusion) of cream production example 1 5.0 mass%
Baicalein 0.1% by mass
Stearic acid 2.0% by mass
Glycerol monostearate 2.0% by mass
Cetanol 3.0% by mass
Cholesterol 0.5% by mass
Petrolatum 2.0% by mass
Squalane 10.0% by mass
Liquid paraffin 10.0% by mass
Dimethylpolysiloxane 1.0% by mass
Sodium glutamate 2.0% by mass
Glycerin 5.0% by mass
Dipropylene glycol 3.0% by mass
Nicotinic acid amide 1.0% by mass
Paraben 0.2% by mass
Perfume Appropriate amount of purified water

(Formulation example 6) Polymer micelle of sunscreen production example 1 (ceramide inclusion) 1.0 mass%
Sodium carboxymethylcellulose 0.3% by mass
Citric acid 0.01% by mass
Sodium citrate 0.05% by mass
1,3-Putylene glycol 7.0% by mass
Glycerin 8.0% by mass
Sorbitan monostearate 0.5% by mass
Monooleic acid polyoxyethylene sorbitan (20) 0.5% by mass
Sorbitan sesquioleate 0.5% by mass
Cetanol 2.0% by mass
2-Methoxyethyl paramethoxycinnamate 10.0% by mass
Ethanol 10.0% by mass
Preservative Appropriate amount of purified water Residual

(Formulation example 7) Polymer micelle of liquid foundation production example 1 (astaxanthin inclusion) 3.2 mass%
Sodium glutamate 1.5% by mass
Octamethylcyclotetrasiloxane 20.0% by mass
Polyoxyethylene oleyl ether 4.0% by mass
Polyoxyethylene hydrogenated castor oil 3.0% by mass
Aluminum monostearate 0.01% by mass
Liquid paraffin 12.0% by mass
Dimethylpolysiloxane 5.0% by mass
12-hydroxystearic acid 1.0% by mass
Nylon powder 4.5% by mass
Black iron oxide 1.5% by mass
Yellow iron oxide 3.0% by mass
Titanium oxide 5.0% by mass
Red iron oxide 2.0% by mass
Paraben 0.2% by mass
Sorbitol 7.0% by mass
Purified water residue

(Prescription example 8) Polymer micelle of powder foundation production example 1 (Vitamin D inclusion) 2.5% by mass
Zinc stearate 3.0% by mass
Nylon powder 10.0% by mass
Bengala appropriate amount yellow iron oxide appropriate amount black iron oxide appropriate amount methylpolysiloxane 3.0% by mass
Isononyl isononanoate 3.0% by mass
Liquid paraffin 2.0% by mass
Octyldodecanol 1.0 mass%
Preservative Appropriate amount Silicone-treated sericite 40.0% by mass
Silicone-treated mica 10.0% by mass
Silicone-treated titanium oxide 8.0% by mass
Silicone-treated fine particle titanium oxide 5.0% by mass
Silicone-treated talc

(Prescription Example 9) Polymer micelle of Lipstick Production Example 1 (CoQ10 inclusion) 3.2 mass%
Gallic acid 1.2% by mass
Titanium dioxide 4.5% by mass
Red 201 No. 2.5 mass%
Ceresin 4.0% by mass
Candelilla wax 8.0% by mass
Carnauba wax 2.0% by mass
Castor oil 30.0% by mass
Isostearic acid diglyceride 40.0% by mass
Polyoxyethylene hydrogenated castor oil (20EO) 1.0% by mass
Methyl ethyl polysiloxane 5.0% by mass
Glycerin 2.0% by mass
Antioxidant Appropriate amount of purified water Residual

(Formulation Example 10) Eyeliner alkyl acrylate copolymer emulsion 30.0% by mass
1,3-Putylene glycol 15.0% by mass
Black iron oxide 15.0% by mass
Acrylic acid / alkyl methacrylate copolymer 0.1% by mass
Sodium hydroxide 0.04% by mass
Sodium carboxymethylcellulose 2.0% by mass
Polymer micelle of Production Example 1 (CoQ10 inclusion) 3.2 mass%
Preservative Appropriate amount of purified water Residual

(Prescription Example 11) Eyeshadow (Powder Type)
Sericite 20.0% by mass
Mica 15.0% by mass
Magnesium stearate 3.0% by mass
Titanium oxide Appropriate amount Polymer micelle of Production Example 1 (Vitamin A inclusion) 3.0% by mass
Coloring agent Suitable amount Liquid paraffin 4.0% by mass
Cetyl 2-ethylhexanoate 2.5% by mass
Preservative Appropriate amount of talc Residue

(Formulation example 12) mascara stearic acid 2.0 mass%
Carnauba wax 2.0% by mass
Beeswax 3.0% by mass
Monooleic acid polyoxyethylene sorbitan POE (20) 1.0% by mass
Sorbitan sesquioleate 0.5% by mass
Alkyl acrylate copolymer emulsion 1.0% by mass
Triethanolamine 1.1% by mass
Propylene glycol 1.0% by mass
Black iron oxide 10.0% by mass
Kaolin 10.0 mass%
Acrylic acid / alkyl methacrylate copolymer 0.2% by mass
Sodium hydroxide 0.08% by mass
Sodium carboxymethylcellulose 2.5% by mass
Polymer micelle of production example 1 (cholesterol inclusion) 2.5% by mass
Preservative Appropriate amount of purified water Residual

(Formulation example 13) Styling gel carboxy vinyl polymer 0.1% by mass
Acrylic acid / alkyl methacrylate copolymer 0.1% by mass
Sodium hydroxide 0.08% by mass
Vinylpyrrolidone / vinyl acetate copolymer solution 10.0% by mass
Sodium pyrrolidonecarboxylate 0.1% by mass
Polymer micelle of production example 1 (astaxanthin inclusion) 1.0 mass%
Purified water residue

(Prescription Example 14) Polymer micelle (cholesterol inclusion) in Beauty Nail Preparation Example 1 2.5% by mass
Ascorbyl divalmitate 1.0% by mass
Isoptyl methacrylate copolymer 18.0% by mass
Acrylamide resin 8.0% by mass
Acetyltributyl citrate 1.5% by mass
Sucrose acetate isobutyrate 4.5% by mass
Ethyl acetate 6.0% by mass
14.5% by mass of butyl acetate
Isopropyl alcohol 30.0% by mass
Purified water residue

(Prescription Example 15) Polymer micelle (Vitamin K inclusion) in Production Example 1 of roll-on type anti-odour antiperspirant 2.5% by mass
Ethanol 35.0% by mass
1,3-butanediol 5.0% by mass
Hydroxypropyl cellulose 1.0% by mass
Chlorhydroxyaluminium 5.0% by mass
Zinc paraphenolsulfonate 2.5% by mass
Green tea extract 5.0% by mass
Purified water residue

(Formulation Example 16) Polymer micelle (Vitamin D inclusion) in Production Example 1 of cold-feel sprain poultice liquid 4.0% by mass
1-menthol 3.0% by mass
d-Camphor 2.0% by mass
Methyl salicylate 4.0% by mass
Indomethacin 0.5% by mass
Ptylhydroxyanisole 0.01% by mass
Ethanol 40.0% by mass
Purified water residue

(Prescription example 17) Polymer micelle (vitamin A inclusion) of the disinfectant preparation example 1 2.5% by mass
Benzalkonium chloride 0.3% by mass
Water-soluble chitosan derivative 3.0% by mass
Ethanol 60.0% by mass
Purified water residue

Claims (5)

Slow release of a hydrophobic substance from a polymer micelle, characterized in that a polymer micelle comprising a block copolymer represented by the following formulas (1) to (2) encapsulating a hydrophobic substance and butylene glycol coexist Method.
[In each formula, R ¹ and R ³ each independently represents a hydrogen atom or a lower alkyl group substituted or unsubstituted by an optionally protected functional group, and R ² represents a hydrogen atom, saturated or unsaturated, R ⁴ represents a saturated C _{1 to} C ₂₉ aliphatic carbonyl group or arylcarbonyl group, R ⁴ represents a hydroxyl group, a saturated or unsaturated C _{1 to} C ₃₀ aliphatic oxy group or an aryl-lower alkyloxy group, and R ⁵ represents Represents a hydrogen atom or a benzyl group (provided that R ⁵ can be arbitrarily selected in each amino acid unit in one block copolymer. In addition, the hydrogen atom in R ⁵ represents 0 to 60% of the whole amino acid unit. occupied, and if present is present randomly.), L ¹ and L ² each independently represents a linking group, n is an integer of 10 to 2500, x is an integer of 10 to 300 Ri, y represents an integer 2. ] 2. The block copolymer represented by the formula (1) to the formula (2) according to claim 1, wherein the hydrogen atom in R ⁵ is 0 to 50% based on the entire amino acid unit. A method for sustained release of a hydrophobic substance from the polymer micelle as described. 2. The block copolymer represented by the formula (1) to the formula (2) according to claim 1, wherein the hydrogen atom in R ⁵ is 0 to 20% based on the entire amino acid unit. A method for sustained release of a hydrophobic substance from the polymer micelle as described.   The method for sustained release of a hydrophobic substance from polymer micelles according to claim 1, wherein the average particle size of the polymer micelles according to claim 1 is in the range of 40 to 600 nm.   The method for sustained release of a hydrophobic substance from polymer micelles according to claim 1, wherein the average particle size of the polymer micelles according to claim 1 is in the range of 40 to 200 nm.