JP2602023B2 - External preparation for skin - Google Patents
External preparation for skinInfo
- Publication number
- JP2602023B2 JP2602023B2 JP62140657A JP14065787A JP2602023B2 JP 2602023 B2 JP2602023 B2 JP 2602023B2 JP 62140657 A JP62140657 A JP 62140657A JP 14065787 A JP14065787 A JP 14065787A JP 2602023 B2 JP2602023 B2 JP 2602023B2
- Authority
- JP
- Japan
- Prior art keywords
- extract
- skin
- external preparation
- present
- effect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Description
【発明の詳細な説明】 ［産業上の利用分野］ 本発明は、新規な皮膚外用剤に関し、さらに詳しく
は、オグルマ抽出物、ホソバオグルマ抽出物、カセンソ
ウ抽出物又は旋覆花抽出物から選ばれる一種又は二種以
上を美白成分として含有することを特徴とする皮膚外用
剤に関するものである。DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a novel external preparation for skin, and more particularly, is selected from an Ogrum extract, a Sophora serrata extract, a gypsophila extract or a swirling flower extract. The present invention relates to an external preparation for skin characterized by containing one or more kinds as a whitening component.
本発明の目的とするところは、日焼けによる皮膚の黒
色化・シミ・ソバカスの防止及び改善効果を有する、美
白効果に優れた皮膚外用剤に関する。It is an object of the present invention to provide a skin external preparation having an effect of preventing and improving skin blackening, spots and freckles due to sunburn and having an excellent whitening effect.
［従来の技術］ 従来、植物抽出物として種々のもの知られており、甘
草、黄柏、紫根等の抽出物が抗炎症作用を有するものと
して、肌荒れ防止、肌荒れ改善効果を期待して皮膚外用
剤に配合する試みがなされてきた。[Prior Art] Conventionally, various types of plant extracts are known, and extracts such as licorice, yellowtail, purple root and the like have anti-inflammatory effects. Attempts have been made to incorporate them into
［発明が解決しようとする問題点］ しかしながら、従来使用されてきた植物抽出物では、
有効な肌荒れ改善効果を有するものは限られていた。ま
た、天然物由来であることから、例えば黄柏や紫根のよ
うに、肌荒れ改善効果を有していても、特有の強い色や
臭いを有する場合があり、製品に配合する上で、配合量
や剤型等に制限があるといった問題もあった。[Problems to be Solved by the Invention] However, in plant extracts that have been conventionally used,
Those having an effective skin roughness improving effect have been limited. In addition, since it is derived from natural products, even if it has an effect of improving skin roughness, for example, like yellow oak or purple root, it may have a unique strong color or odor. There is also a problem that there are restrictions on the dosage form and the like.
［問題点を解決するための手段］ 本発明者等は、係る点に鑑み、種々の植物抽出物につ
いて鋭意研究した結果、オグルマ、ホソバオグルマ、カ
センソウ又は旋覆花の抽出物が優れた抗炎症作用及び美
白作用を有しており、かつこれを含有する皮膚外用剤に
おいて顕著な美白効果が得られることを見出し、本発明
を完成させたのである。[Means for Solving the Problems] In view of the above points, the present inventors have conducted intensive studies on various plant extracts, and as a result, it has been found that the extract of Oguma, Hosobaogoruma, Epimedium or Capsicum flower has excellent anti-inflammatory properties. The present inventors have found that they have an action and a whitening effect, and that a remarkable whitening effect can be obtained with an external preparation for skin containing the same, thereby completing the present invention.
すなわち本発明は、オグルマ抽出物、ホソバオグルマ
抽出物、カセンソウ抽出物又は旋覆花抽出物から選ばれ
る一種又は二種以上（以下オグルマ抽出物という）を美
白成分として含有することを特徴とする皮膚外用剤を提
供するものである。That is, the present invention provides a skin characterized by containing, as a whitening component, one or two or more kinds (hereinafter referred to as "oguruma extract") selected from an oguruma extract, a sycamore extract, a licorice extract or a swirling flower extract. It provides an external preparation.
本発明において必須に使用されるオグルマ抽出物と
は、オグルマ（Inula britannica L.subsp.japonica KI
TAM.）、ホソバオグルマ（Inula britannica L.subsp.l
inariaefolia KITAM.）、カセンソウ（Inula salicina
L.）から選ばれるオグルマ属植物の花・葉・茎・全草又
は一般に知られている旋覆花から抽出して得られるもの
である。抽出方法は特に限定しないが、例えば抽出溶媒
として、水、メチルアルコール・エチルアルコール等の
低級一価アルコール、プロピレングリコール・1,3−ブ
チレングリコール等の液状多価アルコール、酢酸エチル
エステル等の低級アルキルエステル、ベンゼン・ヘキセ
ン等の炭化水素、エチルエーテル等が挙げられ、これら
の一種、または二種以上を組み合わせて使用し得る。こ
れらの抽出溶媒と共に室温又は加温して抽出し、ろ過し
て得られる抽出液、またはこれを濃縮したものが用いら
れる。The Oguma extract essentially used in the present invention is Oguma (Inula britannica L.subsp.japonica KI)
TAM.), Hosobaogoruma (Inula britannica L.subsp.l
inariaefolia KITAM.), balsam (Inula salicina)
L.), and can be obtained by extracting from flowers, leaves, stems, whole plants, or commonly known swirling flowers of the genus Orgrum. The extraction method is not particularly limited. Examples of the extraction solvent include water, lower monohydric alcohols such as methyl alcohol and ethyl alcohol, liquid polyhydric alcohols such as propylene glycol and 1,3-butylene glycol, and lower alkyls such as ethyl acetate. Examples thereof include esters, hydrocarbons such as benzene and hexene, and ethyl ethers, and these can be used alone or in combination of two or more. An extract obtained by extracting with room temperature or heating with these extraction solvents and filtering, or a concentrated extract thereof is used.
皮膚外用剤中におけるオグルマ抽出物の含有量は、少
なすぎる場合は効果がなく、固形分として0.001〜10.0
重量％の範囲が本発明の目的の為には十分であり、また
製品配合上からは抽出液として0.01〜20.0重量％の範囲
であれば好ましく、特に固形分として0.01〜5.0重量
％、抽出液として0.1〜10.0重量％の範囲であればより
好ましい。The content of Oguma extract in the skin external preparation is ineffective if too small, and is 0.001 to 10.0 as solids.
% Is sufficient for the purpose of the present invention, and from the viewpoint of product formulation, it is preferable that the extract is in the range of 0.01 to 20.0% by weight, especially 0.01 to 5.0% by weight as the solid content, Is more preferably in the range of 0.1 to 10.0% by weight.
本発明において上記オグルマ抽出物を配合する皮膚外
用基材としては、通常化粧品・医薬部外品・医薬品に用
いられる水性成分、粉末、界面活性剤、油分、保湿剤、
アルコール類、pH調整剤、防腐剤、酸化防止剤、増粘
剤、色素、香料等を必要に応じて適宜配合して調製され
たものであれば良い。In the present invention, as the external skin substrate containing the Oguruma extract, aqueous components usually used in cosmetics, quasi-drugs, and pharmaceuticals, powders, surfactants, oils, humectants,
Any material may be used as long as it is prepared by appropriately mixing alcohols, pH adjusters, preservatives, antioxidants, thickeners, pigments, fragrances, and the like as needed.
本発明でいう皮膚外用剤の剤型は特に限定されず、化
粧水、乳液、クリーム、パック、軟膏、分散液等の剤型
とすることができる。The dosage form of the external preparation for skin referred to in the present invention is not particularly limited, and may be a dosage form such as a lotion, an emulsion, a cream, a pack, an ointment, a dispersion and the like.
また、本発明の皮膚外用剤には、オグルマ抽出物の
外、公知の薬剤、例えば、グリチルレチン酸及びその誘
導体、インドメタシン等の抗炎症剤、アスコルビン酸、
グリタチオン及びこれらの誘導体、プラセンタエキス、
当帰エキス、桑白皮エキス等の美白効果を有する薬剤、
紫外線吸収剤等を組み合わせて配合することも可能であ
り、相乗効果を期待して製品に併用しても差し支えな
い。In addition, in the skin external preparation of the present invention, in addition to the Oguma extract, known drugs, for example, glycyrrhetinic acid and its derivatives, anti-inflammatory agents such as indomethacin, ascorbic acid,
Glitathione and their derivatives, placenta extract,
Toki extract, mulberry bark extract and other agents having a whitening effect,
It is also possible to mix and combine an ultraviolet absorber and the like, and it may be used in combination with a product in anticipation of a synergistic effect.
次に本発明に係るオグルマ抽出物の美白作用を示すた
めに次の試験を行なった。Next, the following test was conducted in order to show the whitening effect of the Oguma extract according to the present invention.
（チロシナーゼ活性阻害試験） 試料溶液：旋覆花エチルアルコール抽出物を1/10Mリン
酸緩衝液（pH6.8）に分散・溶解して試料溶液とした。(Tyrosinase activity inhibition test) Sample solution: A swirling flower ethyl alcohol extract was dispersed and dissolved in a 1/10 M phosphate buffer (pH 6.8) to obtain a sample solution.
酵素溶液：チロシナーゼ（26,000単位：シグマ社）10mg
を1/10Mリン酸緩衝液（pH6.8）に溶解する。Enzyme solution: Tyrosinase (26,000 units: Sigma) 10mg
Is dissolved in 1/10 M phosphate buffer (pH 6.8).
基質溶媒:L−DOPA（東京化成）198.0mgを1/10Mリン酸緩
衝液（pH6.8）100mlに溶解する。Substrate solvent: 198.0 mg of L-DOPA (Tokyo Kasei) is dissolved in 100 ml of 1/10 M phosphate buffer (pH 6.8).
測定方法：試料溶液3.0mlに酵素溶液0.1ml及び1/10Mリ
ン酸緩衝液（pH6.8）0.9mlを加えトータル4.0mlとし、3
0℃にて10分間インキュベートする。ここで、あらかじ
め30℃でインキュベートしておいた基質溶液1.0mlをこ
の反応溶液に加え、10分間反応させる。ついで475nmに
於ける吸光度（ODS）を測定する。さらに、加熱失活さ
せた酵素を用いて同様に反応させた吸光度（ODHE）及び
試料無添加のときの吸光度（ODB）を測定し、次式より
チロシナーゼ活性の阻害率を算出する。Measurement method: 0.1 ml of enzyme solution and 0.9 ml of 1/10 M phosphate buffer (pH 6.8) were added to 3.0 ml of sample solution to make a total of 4.0 ml.
Incubate at 0 ° C for 10 minutes. Here, 1.0 ml of the substrate solution, which has been incubated at 30 ° C. in advance, is added to the reaction solution and reacted for 10 minutes. Next, the absorbance (OD S ) at 475 nm is measured. Further, the absorbance (OD HE ) and the absorbance (OD B ) when no sample was added were measured in the same manner using the heat-inactivated enzyme, and the inhibition rate of tyrosinase activity was calculated from the following equation.
結果を表１に示す。 Table 1 shows the results.
表１の結果から明らかな如く、本発明に係る旋覆花抽
出物は、チロシナーゼ活性阻害効果を有することが確認
された。 As is clear from the results in Table 1, it was confirmed that the swirling flower extract according to the present invention had a tyrosinase activity inhibitory effect.
［実施例］ 次に、本発明について、実施例を挙げてさらに説明す
る。これらは本発明を何ら限定するものではない。[Examples] Next, the present invention will be further described with reference to examples. They do not limit the invention in any way.
実施例［１］ クリーム （処方） （重量％） （１）オグルマ葉エーテル抽出物（固形分として）3.0 （２）ステアリン酸 1.0 （３）ステアリルアルコール 4.0 （４）モノステアリン酸グリセリン 3.0 （５）硬化油 7.0 （６）流動パラフィン 10.0 （７）サフラワーオイル 2.0 （８）ソルビタンセスキオレエート 1.0 （９）香料 0.1 （10）カルボキシビニルポリマー 0.1 （11）水酸化ナトリウム 0.05 （12）防腐剤 0.1 （13）精製水 残量 （製法） Ａ （１）〜（９）を加熱溶解する。Example [1] Cream (Formulation) (% by weight) (1) Ogrum leaf ether extract (as solid) 3.0 (2) Stearic acid 1.0 (3) Stearyl alcohol 4.0 (4) Glycerin monostearate 3.0 (5) Hardened oil 7.0 (6) Liquid paraffin 10.0 (7) Safflower oil 2.0 (8) Sorbitan sesquioleate 1.0 (9) Fragrance 0.1 (10) Carboxyvinyl polymer 0.1 (11) Sodium hydroxide 0.05 (12) Preservative 0.1 ( 13) Remaining purified water (Preparation method) A Heat and dissolve (1) to (9).
Ｂ （10）〜（13）を加熱溶解する。B. Dissolve (10) to (13) by heating.
Ｃ ＡにＢを加えて乳化し、冷却してクリームを得る。Add B to CA and emulsify and cool to obtain a cream.
比較例［１］ クリーム 実施例［１］の処方中、（１）を除いてクリームとす
る。Comparative Example [1] Cream In the formulation of Example [1], cream was used except for (1).
上記の如くして得られた実施例［１］、比較例［１］
のクリームを用いて使用テストを行なった。使用テスト
は25〜45才の10名の女性をパネルとし、毎日朝と夜の２
回、洗顔後適量を顔の左右に実施例又は比較例のクリー
ムを４週間にわたって塗布することにより行なった。評
価は、シミ・ソバカスに対する効果を判定した。評価結
果は表２に示す。尚、表中の値は各ランクに評価したパ
ネル数を示す。Example [1] and Comparative Example [1] obtained as described above.
The use test was performed using the cream of the present invention. The usage test was conducted on a panel of 10 women aged 25 to 45 years old.
After the face was washed, an appropriate amount was applied by applying the cream of the example or the comparative example to the left and right sides of the face for 4 weeks. The evaluation evaluated the effect on spots and freckles. Table 2 shows the evaluation results. The values in the table indicate the number of panels evaluated for each rank.
表２の結果から明らなか如く、実施例［１］のクリー
ムの使用によってシミ・ソバカスが目立たなくなったと
いう効果が高いことが実証された。 As is evident from the results in Table 2, it was demonstrated that the use of the cream of Example [1] was highly effective in making stains and freckles less noticeable.
実施例［２］ 軟膏 （処方） （重量％） （１）オグルマ全草50％1,3−ブチレ ングリコール抽出液 1.0 （２）カルボキシビニルポリマー 1.0 （３）ヒドロキシエチルセルロース 1.0 （４）ポリエチレングリコール 10.0 （５）エチリアルコール 30.0 （６）ジイソプロピルアジペート 2.0 （７）ジイソプロパノールアミン 1.1 （８）精製水 残量 （製法） Ａ （８）の一部に（２）、（３）を膨潤させる。Example [2] Ointment (Formulation) (% by weight) (1) Oguma whole plant 50% 1,3-butylene glycol extract 1.0 (2) Carboxyvinyl polymer 1.0 (3) Hydroxyethyl cellulose 1.0 (4) Polyethylene glycol 10.0 (5) Ethyl alcohol 30.0 (6) Diisopropyl adipate 2.0 (7) Diisopropanolamine 1.1 (8) Remaining purified water (Production method) A Swell (2) and (3) in part of (8).
Ｂ （１）、（４）〜（６）をＡに添加、撹拌する。B Add (1), (4) to (6) to A and stir.
Ｃ （８）の一部に（７）を溶解してＢに添加する。C) (7) is dissolved in a part of (8) and added to B.
Ｄ Ｃに残量の水を加え、均一に撹拌して軟膏を得る。The remaining amount of water is added to DC and stirred evenly to obtain an ointment.
比較例［２］ 軟膏 実施例［２］の処方中、（１）を除いて軟膏とする。Comparative Example [2] Ointment In the formulation of Example [2], an ointment was prepared except for (1).
上記の如くして得られた実施例［２］及び比較例
［２］の軟膏を実際に使用したところ、実施例［２］の
軟膏は比較例［２］の軟膏に比べて優れた美白効果を有
するものであった。When the ointments of Example [2] and Comparative Example [2] obtained as described above were actually used, the ointment of Example [2] had a superior whitening effect as compared with the ointment of Comparative Example [2]. It had the following.
実施例［３］ 化粧水 （処方） （重量％） （１）旋覆花50％エチルアルコール抽出液 0.5 （２）エチルアルコール 7.0 （３）1,3−ブチレングリコール 7.0 （４）酢酸トコフェロール 0.05 （５）防腐剤 0.1 （６）香料 0.05 （７）モノオレイン酸ポリオキシ エチレンソルビタン（20E.O.） 1.0 （８）乳酸ナトリウム 0.2 （９）セイヨウトチノキエキス 0.5 （10）精製水 残量 （製法） Ａ （１）〜（７）を混合溶解する。Example [3] Lotion (Prescription) (% by weight) (1) Twisted flower 50% ethyl alcohol extract 0.5 (2) Ethyl alcohol 7.0 (3) 1,3-butylene glycol 7.0 (4) Tocopherol acetate 0.05 ( 5) Preservatives 0.1 (6) Fragrances 0.05 (7) Polyoxyethylene sorbitan monooleate (20E.O.) 1.0 (8) Sodium lactate 0.2 (9) Horse chestnut extract 0.5 (10) Remaining purified water (production method) A (1) to (7) are mixed and dissolved.
Ｂ （８）〜（10）を混合溶解する。B: Mix and dissolve (8) to (10).
Ｃ ＢにＡを加えて混合し、化粧水を得る。Add A to CB and mix to obtain a lotion.
［発明の効果］ 以上詳述した如く、本発明は、オグルマ抽出物、ホソ
バオグルマ抽出物、カセンソウ抽出物又は旋覆花抽出物
から選ばれる一種又は二種以上を美白成分として必須に
含有することにより、その作用効果が十分発揮された新
規な皮膚外用剤を提供するものである。[Effects of the Invention] As described in detail above, the present invention essentially contains one or more selected from the extract of Ogrum, the extract of Oleaceae, the extract of gypsophila or the swirling flower as a whitening component. Accordingly, the present invention provides a novel external preparation for skin in which the function and effect are sufficiently exhibited.
すなわち、本発明により、日焼けによる皮膚の黒色化
・シミ・ソバカスの防止及び改善効果を有する、美白効
果に優れ、かつ着色や特異臭も少ないことから利用範囲
の広い皮膚外用剤の提供が可能となったのである。That is, according to the present invention, it is possible to provide a skin external preparation having a wide range of use since it has an effect of preventing and improving skin blackening, spots, and freckles due to sunburn, has an excellent whitening effect, and has little coloring and a peculiar odor. It has become.
Claims (1)
カセンソウ抽出物又は旋覆花抽出物から選ばれる一種又
は二種以上を美白成分として含有することを特徴とする
皮膚外用剤。1. An extract of Oguruma, an extract of Hosoba-oguruma,
An external preparation for skin, characterized by containing one or more selected from licorice extracts or swirling flower extracts as whitening ingredients.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62140657A JP2602023B2 (en) | 1987-06-04 | 1987-06-04 | External preparation for skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62140657A JP2602023B2 (en) | 1987-06-04 | 1987-06-04 | External preparation for skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63303919A JPS63303919A (en) | 1988-12-12 |
| JP2602023B2 true JP2602023B2 (en) | 1997-04-23 |
Family
ID=15273736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62140657A Expired - Fee Related JP2602023B2 (en) | 1987-06-04 | 1987-06-04 | External preparation for skin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2602023B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008059870A1 (en) * | 2006-11-17 | 2008-05-22 | Ltt Bio-Pharma Co., Ltd. | Heat shock protein inducer, skin preparation for external use, food and drug containing the same, and method of producing heat shock protein inducer |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08283143A (en) * | 1995-04-14 | 1996-10-29 | Kose Corp | Skin preparation for external use |
| JP2001199862A (en) * | 2000-01-14 | 2001-07-24 | Ichimaru Pharcos Co Ltd | Cosmetic composition containing moisture retention plant extract |
| JP2002029926A (en) * | 2000-07-19 | 2002-01-29 | Pola Chem Ind Inc | Agent for reconstruction of structure of cutis collagen fascicle and composition including the same |
| JP2010083804A (en) * | 2008-09-30 | 2010-04-15 | Saishunkan Seiyakusho:Kk | Skin lightening cosmetic |
-
1987
- 1987-06-04 JP JP62140657A patent/JP2602023B2/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 赤松金芳著，「新訂和漢薬」医歯薬出版株式会社，昭和５５年１０月１５日，第１版第５刷発行，第３０頁 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008059870A1 (en) * | 2006-11-17 | 2008-05-22 | Ltt Bio-Pharma Co., Ltd. | Heat shock protein inducer, skin preparation for external use, food and drug containing the same, and method of producing heat shock protein inducer |
| JP2008127296A (en) * | 2006-11-17 | 2008-06-05 | Sunnyhealth Co Ltd | Heat shock protein inducer, skin care preparation and food comprising the same and method for producing heat shock protein inducer |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS63303919A (en) | 1988-12-12 |
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