JP2002145752A - Skin care preparation and composition for skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin care preparation and a composition for skin care preparation having excellent bleaching/beautifying effect to the skin such as propbylactic for pigmentation by including an extract of a specific plant. SOLUTION: This skin care preparation is blended with extract of a plant belonging to Hypoxidaceae.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an external preparation for skin containing an extract from a specific plant, and more specifically, to prevent the occurrence of pigmentation by containing a specific plant extract. The present invention relates to a skin external preparation having an excellent skin whitening and skin whitening effect and a skin external preparation composition obtained by further blending a whitening agent, an antioxidant, an anti-inflammatory agent, an ultraviolet inhibitor and the like with the above extract.

[0002]

2. Description of the Related Art Conventionally, medicinal components have been used in skin external preparations such as emulsions, creams, lotions, packs, detergents, dispersions, ointments, and external preparations for the purpose of imparting a predetermined medicinal effect to them. Have been added. For example, whitening agents such as ascorbic acid, glutathione, and hydroquinone have been added in order to prevent skin blackening caused by sunburn and the like, and spots and freckles caused by pigmentation.

[0003]

However, these whitening agents may not have sufficient whitening / skinning effects or may not be able to achieve the desired medicinal effect due to deterioration in the preparation. Improvement was desired.

[0004]

Means for Solving the Problems The present inventors have searched for many plant components in order to find a new compound having a whitening / skin-skinning effect, and found that an extract from a specific plant has high melanin production. The present inventors have found that the extract has an inhibitory action, and that the extract can be blended as a medicinal ingredient in a skin external preparation, and thus completed the present invention.

That is, the present invention relates to the family
The present invention provides an external preparation for skin having an excellent skin-whitening and skin-excellent effect, characterized by containing a plant extract of POXIDACEAE).

The present invention also relates to the following components (a) and (b): (a) an extract of a plant of the family HYPOXIDACEAE (b) a whitening agent, an antioxidant, an anti-inflammatory agent, and an ultraviolet inhibitor. An object of the present invention is to provide a composition for external use on the skin, characterized in that it contains one or two or more selected active agents.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION Extracts of the family Acalyptaceae used in the present invention include, for example, whole plants of these plants,
Or after drying or cutting without drying any one or more of the leaves, stems, petals, seeds, rhizomes, rhizomes, roots, etc.,
It is obtained by extraction with a suitable solvent at a low temperature or at a normal temperature to a heating temperature.

[0008] As the extraction solvent, generally, water, lower 1
Polyhydric alcohols (methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, etc.), liquid polyhydric alcohols (propylene glycol, 1,3-butylene glycol, etc.), lower alkyl esters (ethyl acetate, etc.) ), Hydrocarbons (benzene, hexane, pentane, etc.), ketones (acetone, methyl ethyl ketone, etc.), ethers (diethyl ether, tetrahydrofuran, dipropyl ether), acetonitrile and the like.

As an example of a preferable extraction method, extraction is performed at room temperature for 1 to 5 days using ethanol or 1,3-butylene glycol having a water content of 0 to 100% by volume, followed by filtration, and the obtained filtrate is further filtered. A method in which the mixture is left to mature for about one week and then filtered again.

[0010] The kind and production place of the Quinbasaceae plant are not particularly limited. For example, a plant native to Thailand, Molineria latifolia (scientific name: Molineria latifolia)
Herb. Ex Kurz) is preferably used.

The content of the above plant extract in the present invention is preferably 0.00001 to 5% by mass (hereinafter simply referred to as "%") as a dry solid content, more preferably 0.0001 to 2%. It is. When the content is within this range, the plant extract can be stably compounded, and a high whitening / beautifying effect can be exhibited. When an extract is used, the content of the dry solid content as a solute may be within the above range, and the concentration of the extract is not limited at all.

The plant extract (component (a)) of the present invention comprises:
Even when it is simply blended in an external preparation, it shows excellent whitening and skin effect, but furthermore, a medicinal agent (component (b)) selected from the group consisting of a whitening agent, an antioxidant, an anti-inflammatory agent, and a UV inhibitor. By adding, it is possible to obtain an even more excellent whitening / beautifying effect. Specific examples of the medicinal agent that can be used as the component (b) include the following.

(Whitening Agents) As whitening agents, vitamin C and its derivatives and salts thereof, placenta extract, licorice extract, yoquinin extract, asparagus extract, age extract, kiwi extract, and strawberry extract , Jinjin extract, cinnamon extract, eleuthero extract, coffee extract, rice bran extract, wheat germ extract, saicin extract, hawthorn extract, white lily extract, peony extract, soy extract, green tea, black tea, Tea extracts such as oolong tea, molasses extract, juniper extract, beech bud extract, grape extract, hop extract, squid extract,
Examples include a mocca extract, an arhat extract, a gougy extract, and a seaweed extract. Among these whitening agents, particularly preferred are vitamin C and its derivatives, salts thereof, and placental extracts.

(Antioxidants) Examples of antioxidants include mannitol, rutin and its derivatives, quercetin, phospholipids, carotenoids such as beta-carotene and astaxanthin, retinol and its derivatives (retinol palmitate, retinol acetate, etc.) , Retinal and its derivatives, vitamins A such as dehydroretinal, pyridoxines (eg, pyridoxine hydrochloride, pyridoxine dioctanoate), nicotinic acids (eg, nicotinamide, benzyl nicotinate), dibutylhydroxytoluene (BHT), butylhydroxyl Anisole (BHA),
Vitamin E and its derivatives and salts thereof, carrot extract, melissa extract, yasazitsu extract and the like. Among these antioxidants, particularly preferred ones include vitamin E and its derivatives and salts thereof.

(Anti-Inflammatory Agent) Further, anti-inflammatory agents include chondroitin sulfate and its derivatives, allantoin, arnica extract, hypericum extract, oak extract, goldfish extract, watercress extract, comfrey extract, salvia Extract, siconium extract, birch extract, calendula extract, elder extract, asparagus extract, mud mushroom extract, eucalyptus extract, astragalus extract, glycyrrhizic acid and glycyrrhetinic acid and their derivatives and salts thereof, Aloe extract, perilla extract, mugwort extract, chamomile extract and the like can be mentioned.
Among these anti-inflammatory agents, particularly preferred are:
Glycyrrhizic acid and glycyrrhetinic acid and their derivatives and their salts are mentioned.

(Ultraviolet inhibitor) In addition, as an ultraviolet inhibitor, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 2-ethylhexyl paramethoxycinnamate, oxybenzone, 4-ter
t-butyl-4'-methoxydibenzoylmethane, titanium oxide, fine particle titanium oxide, zinc oxide and the like.
Among these ultraviolet inhibitors, particularly preferred are 2-ethylhexyl paramethoxycinnamate, titanium oxide, fine particle titanium oxide, and zinc oxide.

The content of the pharmaceutically active agent of the above-mentioned component (b) in the external preparation for skin of the present invention varies depending on the type of the pharmaceutically active agent, but is preferably in the following range. Within this range, when combined with the component (a), it does not affect the stability over time of the component (a) in the preparation, and can exhibit a higher whitening / skin skin effect.

That is, in the skin external preparation composition of the present invention, when a whitening agent is used as the component (b), its content is preferably 0.00001 to 10%,
More preferably, it is in the range of 0.0001 to 5%. When various extracts are used as an extract as a whitening agent, there is no problem as long as the dry solid content is within this range. Within this range, a skin external preparation exhibiting more excellent whitening / skinning effects and having a good feeling upon use can be obtained.

In the skin external preparation composition of the present invention, when an antioxidant is used as the component (b), the amount of the antioxidant is preferably 0.00001 to 5%, more preferably 0.0001 to 5%. It is in the range of 3%. When the plant extract is used as an antioxidant as it is, there is no problem as long as the dry solid content is within this range. Within this range,
An external preparation for skin which exhibits more excellent antioxidant effect and exhibits excellent whitening and skin-smoothing effects can be obtained.

Further, in the case of using the anti-inflammatory agent as the component (b) in the skin external preparation composition of the present invention, the compounding amount thereof is preferably in the range of 0.00001 to 5%, more preferably 0. 0.0001-3%.
When the plant extract is used as an anti-inflammatory agent as it is, there is no problem as long as the dry solid content is within this range. Within this range, an external preparation for skin which exhibits excellent anti-inflammatory effects and exhibits excellent whitening and skin effect can be obtained.

Further, in the case of using an ultraviolet ray inhibitor as the component (b) in the skin external preparation composition of the present invention, the compounding amount thereof is preferably 0.0001 to 2
0%, more preferably in the range of 0.001 to 10%. Within this range, a skin external preparation that exhibits a more excellent ultraviolet ray preventing effect and also has an excellent whitening and skin-smoothing effect can be obtained.

The component (b), a whitening agent, an antioxidant, an anti-inflammatory agent, and an ultraviolet inhibitor, can be used alone or in combination of two or more.

The skin external preparation and the skin external composition of the present invention can be prepared in various forms known as ordinary skin external preparations according to a conventional method.

Examples of the form of the external preparation for skin and the external preparation composition for skin of the present invention are not particularly limited, and examples thereof include emulsions, creams, lotions, packs, detergents, makeup cosmetics, dispersions, ointments, and the like. It can be used as a cosmetic such as a liquid foundation or a topical medicine.

Depending on the form of the external preparation for skin, in addition to the above-mentioned essential components, components usually used in external preparations for skin such as cosmetics and pharmaceuticals, for example, purified water, lower alcohols, polyhydric alcohols, oily components, powders, Surfactants, thickeners, coloring materials,
Preservatives, humectants, fragrances and the like can be used.

[0026]

EXAMPLES Next, the present invention will be described in more detail with reference to Reference Examples, Test Examples and Examples, but the present invention is not limited thereto.

REFERENCE EXAMPLE 1 Production of a Morinella extract: Dried whole plant of Morinella latifolia native to Thailand, which is a plant belonging to the family Araceae.
50 g of ethyl alcohol to 0 g, and
After extraction for one day, the mixture was filtered to obtain a Molinelia extract. The dry solids content of this extract was 5.3%.

Reference Example 2 Production of yoquinin extract: 10 g of yoquinin (JP)
Then, 100 ml of 70 vol% ethyl alcohol was added thereto, and the mixture was extracted at room temperature for 3 days, and then filtered to obtain a yoquinin extract. At this time, the dry solid content of the yokunin extract was 0.8%.

Test Example 1 Test for inhibition of melanin production and cell viability by cell culture:
B16 melanoma cultured cells derived from mice were used. 2
An appropriate amount of medium was taken in a 6-well petri dish, B16 melanoma cells were inoculated, and allowed to stand at 37 ° C. in a carbon dioxide concentration of 5%. The next day, the final concentration of the Morinella extract obtained in Reference Example 1 was 0 (control), 1, 10, 30, 1000 μg / ml.
The sample preparation solution was added and mixed so that On the fifth day of the culture, the medium was replaced, and the sample preparation solution was added again. next day,
The medium was removed, the cells were washed with a phosphate buffer in one petri dish, and then collected. The whiteness of the cultured B16 melanoma cells was evaluated according to the following criteria. Further, as a comparative example, a similar test was performed on a yokunin extract which is already known to have a melanin production inhibitory action.

(Evaluation Criteria) Evaluation: Contents ++: Very white with respect to control +: Clearly white with respect to control ±: Slightly white with respect to control −: Same black as control There is N. T: Not tested

In addition, for the remaining one petri dish, the cells were fixed with formalin and stained with a 1% crystal violet solution. Cell viability for each sample concentration was measured with a monocerator (Olympus). Table 1 shows the above results.

(Result)

[Table 1]

As is clear from the results in Table 1, the Morinella extract has a high melanin production inhibitory activity and B16
Low toxicity was observed for melanoma cultured cells. Therefore, the whitening agent of the present invention containing the plant extract, by applying it to the skin, exerts an extremely excellent melanin production inhibitory effect, and turns the skin black due to sunburn.
Blemish, freckles and the like can be effectively suppressed.

Example 1 Cream: The product 1 of the present invention was prepared according to the formulation shown in Table 2 and the following production method.
In addition, the creams of Comparative Products 1 and 2 were prepared, and the whitening and skin whitening effects of the Morinella extract were examined by the following test methods. Table 2 shows the results.

(Prescription and results)

[Table 2]

(Production method) A. Mix components (1) to (6) and (9) and heat to 7
Keep at 0 ° C. B. Heat a portion of component (11) and maintain at 70 ° C. C. "B." was added to "A.", and (8) and (10) dissolved in the remainder of (7) and (11) were mixed and cooled to obtain a cream.

(Test method) 27 per test cream
A panel consisting of 15 women aged 54 to 54
After washing the face for 12 weeks, an appropriate amount of the test cream was applied to the face. The whitening and skin effect by applying the test cream were evaluated according to the following criteria.

(Evaluation Criteria) Evaluation Contents Effectiveness: The dullness of the skin became less noticeable than before the application. Slightly effective: Skin dullness became less noticeable than before application. Ineffective: No change from before application.

As shown in the results in Table 2, phosphoric acid-L-
Compared to Comparative Product 1 containing only ascorbyl magnesium and Comparative Product 2 not containing both Morineria extract and phosphate-L ascorbyl magnesium, the cream of the present invention containing the Morineria extract had a It is excellent in prevention of occurrence and improvement, and by applying it to the skin, beautiful skin can be obtained.

Example 2 Cream: The product of the present invention 2 according to the formulation shown in Table 3 and the following production method
7 and comparative products 3 to 7 were prepared, and the whitening / skinning effect when a whitening agent, an antioxidant, an anti-inflammatory agent, and a UV inhibitor were used in combination was examined by the following test method. Table 3 shows the results.

(Prescription and results)

[Table 3]

(Production method) A. Components (1) to (6), (10), (12) and (1)
3) mix and heat to keep at 70 ° C. B. Heat a portion of component (15) and maintain at 70 ° C. C. "B." is added to "A.", and (7)-(8), (1)
After mixing (9), (11) and (14) dissolved in the remainder of 5), the mixture was cooled to obtain a cream.

(Test Method) 27 per test cream
A panel consisting of 15 women aged 54 to 54
After washing the face for 12 weeks, an appropriate amount of the test cream was applied to the face. The whitening and skin effect by applying the test cream were evaluated according to the following criteria.

(Evaluation Criteria) Evaluation: Contents Effectiveness: The dullness of the skin became less noticeable than before the application. Slightly effective: Skin dullness became less noticeable than before application. Ineffective: No change from before application.

As shown in the results in Table 3, the external preparations of the present invention containing the Morinella extract can prevent and improve the occurrence of "dullness" on the skin by applying them to the skin. It became clear that it was possible and had beautiful skin. Furthermore, by applying to the skin an external preparation formulated using a combination of a Morineria extract with a whitening agent, an antioxidant, an anti-inflammatory agent, and a UV inhibitor, the application of an external preparation containing a Morineria extract alone is applied. The effect of preventing and improving the occurrence of “dullness” on the skin can be enhanced synergistically, and a beautiful skin can be obtained.

Example 3 Lotion: A lotion was prepared according to the following formulation and production method, and the whitening and skin effect of the Molinelia extract was examined. As a result, the lotion obtained in this example has excellent stability over time and, when applied to the skin, prevents "dullness" and spots and freckles on the skin due to sunburn, and makes the skin beautiful and transparent. It was a lotion.

(Prescription) Ingredient Mass% (1) Glycerin 5.0 (2) 1,3-butylene glycol 6.5 (3) Polyoxyethylene (20EO) 1.2 Sorbitan monolaurate (4) Ethyl alcohol 8.0 (5) Morineria extract ^{* 1} 1.0 (6) Preservatives proper amount (7) Flavor proper amount (8) Purified water residue * 1 Manufactured in Reference Example 1

(Production method) A. Components (3), (4), (6) and (7) are mixed and dissolved. B. Components (1), (2), (5) and (8) are mixed and dissolved. C. "A." and "B." were mixed to obtain a uniform lotion.

Example 4 Emulsion: An emulsion was prepared according to the following formulation and manufacturing method, and the whitening and skin whitening effect when a Morinella extract and a whitening agent were used in combination was examined. As a result, the milky lotion obtained in this example prevents the skin from `` dullness '' and spots and freckles due to sunburn by using a combination of a molinelia extract and a whitening agent, and has an effect of making the skin beautiful and transparent. Excellent emulsion.

(Formulation) Ingredient Mass% (1) Polyoxyethylene (10EO) 1.0 Sorbitan monostearate (2) Polyoxyethylene (60EO) 0.5 Sorbit tetraoleate (3 ) glyceryl monostearate 1.0 (4) stearic acid 0.5 (5) behenyl alcohol 0.5 (6) squalane 8.0 (7) Morineria extract ^* 1 3.0 (8) placental extract ^* 4 5 0.0 (9) Preservative 0.1 (10) Carboxyvinyl polymer 0.1 (11) Sodium hydroxide 0.05 (12) Ethyl alcohol 5.0 (13) Remaining purified water (14) Appropriate perfume * 1 Manufactured in Reference Example 1 * 4 Nichirei Co., Ltd.

(Production method) A part of components (11), (12) and (13) are mixed by heating and kept at 70 ° C. B. Components (1) to (6) and (9) are mixed by heating,
To keep. C. Add “A.” to “B.”, mix and emulsify uniformly. D. After cooling "C.", (10) and (14), which were dissolved in (7), (8) and the rest of (13), were added and uniformly mixed to obtain an emulsion.

Example 5 Ointment: An ointment was prepared according to the following formulation and manufacturing method, and the whitening / skin-extracting effect of the combined use of the Molineria extract, an anti-inflammatory agent and an antioxidant was examined. As a result, the ointment obtained in this example is excellent in stability over time, and prevents `` dullness '', spots and freckles by using a Morinella extract in combination with an anti-inflammatory agent and an antioxidant, and is more transparent. It was an ointment that could make the skin beautiful.

(Formulation) Ingredient Mass% (1) Stearic acid 18.0 (2) Cetanol 4.0 (3) Triethanolamine 2.0 (4) Glycerin 5.0 (5) Morineria extract ^* 11 0.0 (6) dipotassium glycyrrhizinate ^{* 6} 0.5 (7) dl-α-tocopherol acetate ^{* 8} 0.2 (8) residual amount of purified water * 1 manufactured in Reference Example 1 * 6 manufactured by Maruzen Pharmaceutical Co. * 8 Eisai products

(Production method) A part of components (3), (4) and (8) are mixed by heating and kept at 75 ° C. B. Heat and mix components (1), (2) and (7),
Keep at ° C. C. "A." is gradually added to "B." D. While cooling "C.", (5) and (6) dissolved in the remainder of (8) were added to obtain an ointment.

Example 6 Pack: A pack was prepared according to the following formulation and manufacturing method, and the effect of whitening and skin whitening when a Morinelia extract was blended was examined. As a result, the pack of this example has excellent stability over time,
By applying it to the skin, it was a pack that could prevent "dullness" and spots on the skin and make the skin beautiful and transparent.

(Prescription) Ingredient Content% by mass (1) Polyvinyl alcohol 20.0 (2) Ethyl alcohol 20.0 (3) Glycerin 5.0 (4) Kaolin 6.0 (5) Morinella extract ^{* 1} 1. 0 (6) Preservative 0.2 (7) Fragrance 0.1 (8) Purified water residue * 1 Produced in Reference Example 1

(Production method) A. Mixing components (1), (3), (4) and (8),
Heat to 70 ° C. and stir. B. Mix components (2) and (6). C. After adding the above “B.” to the above “A.” and mixing,
After cooling, (5) and (7) were uniformly dispersed to obtain a pack.

Example 7 Liquid foundation: A liquid foundation was prepared according to the following formulation and manufacturing method, and a Morinella extract and a yoquinin extract and an ultraviolet ray inhibitor (2-methoxyhexyl paramethoxycinnamate, titanium oxide, The effect of whitening and skin whitening when combined with fine particles of titanium oxide and zinc oxide) was examined. As a result, the liquid foundation of this example was excellent in stability over time, and when applied to the skin, was extremely excellent in the effects of preventing skin blackening due to sunburn and the like, and preventing spots and freckles.

(Formulation) Ingredient mass% (1) Lanolin 7.0 (2) Liquid paraffin 5.0 (3) Stearic acid 2.0 (4) Cetanol 1.0 (5) Paramethoxycinnamic acid 0-2-ethylhexyl (6) glycerin 5.0 (7) triethanolamine 1.0 (8) carboxymethylcellulose 0.7 (9) residual purified water (10) titanium oxide 8.0 (11) fine particle titanium oxide 2.0 (12) Zinc oxide 5.0 (13) Mica 15.0 (14) Talc 6.0 (15) Color pigment 6.0 (16) Morineria extract ^{* 1} 0.0
1 (17) Yokuinin extract ^{* 2} 0.
5 (18) Appropriate amount of fragrance * 1 Manufactured in Reference Example 1 * 2 Manufactured in Reference Example 2

(Production method) A. Components (1) to (5) are mixed and dissolved. B. Add components (10) to (15) to "A.", mix uniformly, and keep at 70C. C. Components (6) to (9) are uniformly dissolved and kept at 70 ° C. D. “C.” is added to “B.” and uniformly emulsified. E. FIG. After cooling "D.", the components (16) to (18) were added to obtain a liquid foundation.

[0061]

As described above, the external preparation for skin and the external preparation composition for skin of the present invention, which contain an extract from a specific plant, exhibit a high inhibitory effect on pigmentation and have a soothing effect on the skin. It is effective in preventing and improving skin darkening, spots and freckles due to sunburn, etc., and has excellent whitening and skin effect.

Therefore, the external preparation for skin and the composition thereof of the present invention can be effectively used as cosmetics and pharmaceuticals for whitening and beautiful skin. that's all

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 EG B 35/78 35/78 CJ V M U H F D Q S NTK A61P 17/00 A61P 17/00 17/16 17/16 (72) Inventor Taku Hoshino 48-18 Sakae-cho, Kita-ku, Tokyo Inside Kose Research Laboratory (72) Inventor Yoshihiro Higuchi Chiba, Chiba 4-544-14-3-209 Makuhari-cho, Hanamigawa-ku, Ichiban F-term (reference) 4C083 AA071 AA072 AA111 AA112 AB032 AB211 AB212 AB241 AB242 AB432 AB442 AC012 AC022 AC072 AC102 AC122 AC131 AC211 AC242 AC341 AC342 AC422 AC442 AC471 AC542 AC681 AC791 AC841 AC85 AD112 AD272 AD341 AD391 AD531 AD532 AD571 AD621 AD631 AD641 AD642 AD651 AD662 BB46 BB47 BB51 CC04 CC05 CC07 CC12 DD23 EE16 4C088 AB12 AB14 AB15 AB16 AB19 AB25 AB26 AB29 AB32 AB34 A B38 AB40 AB45 AB51 AB56 AB57 AB59 AB60 AB61 AB62 AB73 AB74 AB77 AB82 AB85 AB86 AC01 AC04 BA10 CA06 CA08 MA02 MA03 MA08 MA09 MA63 NA14 ZA89

Claims (8)

[Claims] 1. An external preparation for skin comprising an extract of a plant of the family HYPOXIDACEAE. 2. The extract of a Quercus sasa family plant is derived from a plant native to Thailand, Molineria latifolia (scientific name: Molineria la
The external preparation for skin according to claim 1, which is an extract of tifolia Herb. ex Kurz). 3. An external preparation for skin, comprising any one of the plant extracts according to claim 1 or 2 as a whitening component or a beautiful skin component. 4. The following components (a) and (b): (a) an extract of a plant belonging to the family HYPOXIDACEAE (b) a medicinal agent selected from the group consisting of a whitening agent, an antioxidant, an anti-inflammatory agent, and an ultraviolet inhibitor. An external preparation composition for skin, comprising one or more kinds. 5. A whitening agent comprising vitamin C and its derivatives and salts thereof, placenta extract, licorice extract, yokuinin extract, asparagus extract, Eijitsu extract, kiwi extract, raspberry extract, kujin extract Stuff, cinnamon extract, eleuthero extract, coffee extract, rice bran extract, wheat germ extract, saicin extract, hawthorn extract, white lily extract, peony extract, soy extract,
Selected from tea extract, molasses extract, juniper extract, beech sprouts extract, grape extract, hop extract, maikaika extract, mocca extract, arhat extract, gongon extract and seaweed extract The skin external preparation composition according to claim 4, which is: 6. Antioxidants include carotenoids such as mannitol, rutin and its derivatives, quercetin, phospholipids, beta-carotene, astaxanthin, retinol and its derivatives, retinal and its derivatives, vitamin A such as dehydroretinal, and pyridoxine. And nicotinic acids, dibutylhydroxytoluene (BHT), butylhydroxyanisole (BHA), vitamin E and its derivatives and salts thereof, carrot extract, melissa extract and yasazitsu extract. 5. The composition for external use on skin according to item 4. 7. The anti-inflammatory agent may be chondroitin sulfate or a derivative thereof, allantoin, arnica extract, hypericum extract, oak extract, goldfish extract, watercress extract, comfrey extract, salvia extract, sicon extract. , Birch extract, calendula extract, elderberry extract, asparagus extract, sapling extract, eucalyptus extract, astragalus extract, glycyrrhizic acid and glycyrrhetinic acid and their derivatives and salts thereof,
The skin external preparation composition according to claim 4, which is selected from an aloe extract, a perilla extract, a mugwort extract, and a chamomile extract. 8. The method according to claim 1, wherein the ultraviolet light inhibitor is 2-hydroxy-4-.
Methoxybenzophenone-5-sulfonic acid sodium salt,
The skin according to claim 4, wherein the skin is selected from 2-ethylhexyl paramethoxycinnamate, oxybenzone, 4-tert-butyl-4'-methoxydibenzoylmethane, titanium oxide, fine particle titanium oxide and zinc oxide. External preparation composition.