JP2001181173A - Bleaching preparation for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a bleaching preparation for external use having extremely high bleaching effects. SOLUTION: This bleaching preparation for external use comprises only an ingredient (A) or the ingredient (A) and an ingredient (B). (A) a bleaching agent comprises an extract from Rubus suavissims S. Lee and (B) one or more medicinal effective agents selected from a bleaching agent, an active oxygen scavenger, an antioxidant, an antiinflammatory agent and an ultraviolet ray inhibitor.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening agent and a whitening agent for external use containing the same, and more particularly to a bean extract which is useful as a whitening agent and this bean extract or a specific pharmaceutically active agent. The present invention relates to an external whitening agent such as a cosmetic or a topical medicine having an excellent whitening effect useful for preventing and improving pigmentation, spots, freckles, etc. after sunburn by suppressing the production of melanin.

[0002]

2. Description of the Related Art Conventionally, skin external preparations for whitening, that is, cosmetics such as emulsions, creams, lotions, packs, detergents, foundations, and the like, and quasi-drugs, dispersions, ointments, creams, and external preparations such as external solutions. To prevent phenomena such as spots and freckles caused by skin darkening and pigmentation caused by sunburn, etc., whitening of vitamin Cs, glutathione, hydroquinone and its derivatives, placenta extract, plant extract, etc. The agent is blended.

[0003]

However, an external preparation for skin containing these whitening agents does not have sufficient effect of the whitening agent or deteriorates in the preparation to obtain the desired effect. In many cases, there has been a demand for improvement and provision of newer whitening ingredients.

[0004]

Means for Solving the Problems In order to solve the above problems, the present inventors have searched a wide variety of plants for the presence of a whitening effect. As a result, the tea tea extract has a high melanin production inhibitory effect. I found that. And a whitening agent containing this extract as an active ingredient can be blended with a skin external preparation,
The present inventors have found that an excellent whitening effect can be obtained by combining with other medicinal ingredients, and completed the present invention.

[0005] That is, the present invention provides a whitening agent containing a tea extract as an active ingredient.

The present invention also provides an external whitening agent containing a tea extract.

Further, the present invention relates to the following components (A) and (B): (A) a tea extract; (B) a whitening agent, an active oxygen scavenger, an antioxidant, an anti-inflammatory agent,
An object of the present invention is to provide a whitening agent for external use characterized by containing one or more kinds of medicinal agents selected from ultraviolet inhibitors.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION The tea tea extract used in the present invention is obtained, for example, by extracting tea tea with an aqueous solvent. The raw material of tea (Rubaceae perennial shrub, Rubus suavi
ssims S. Lee) has been used as sweet tea in China since ancient times. This tea can be subjected to extraction using its leaves or stems, particularly those obtained by drying leaves in the sun, as raw materials. This sweet tea is a sweet tea of Saxifragaceae [Hydrangea macrophylla Seringe var.t.
hunbergii Makino (Saxifragaceae: Saxifragaceae)] is a completely different plant.

The aqueous solvent used for the extraction may be water alone or any mixture of water and one or two polar solvents such as lower alcohols such as methanol and ethanol, and acetone. However, since the active ingredient of the present invention cannot be efficiently extracted with only a polar solvent, it is desirable to always use a mixed solution with water and the mixing ratio of the solvent is 90% or less. Among these solvents, considering that the extract is finally incorporated into cosmetics, quasi-drugs, topical medicines, etc., it is preferable to use water, ethanol, or a mixture thereof in terms of safety. preferable.

[0010] The ratio of bean tea to the solvent at the time of extraction is not particularly limited either.
000 times by mass, especially 5-100 times by mass in terms of extraction operation and efficiency. The extraction temperature is conveniently in the range of the boiling point of the solvent at room temperature to normal pressure, and the extraction time is preferably in the range of 10 minutes to 96 hours.

[0011] Any state can be used, such as the soybean water-based solvent extract obtained as described above, a concentrate thereof, a dried product obtained by removing the solvent from the eluate, and the like.

The content of the tea tea extract in the external preparation for skin of the present invention is preferably 0.00000 as dry solids.
The content is 1 to 5% by mass (hereinafter, simply indicated by "%"), and more preferably 0.00005 to 1.5%. Within this range, the bean tea extract can be stably blended, and a high melanin production inhibitory effect can be exhibited.

[0013] The extract of bean tea of the present invention is used as an active ingredient, and is blended with various types of bases used in usual external preparations for skin according to a conventional method to obtain a whitening cosmetic by formulating. However, when combined with other medicinal ingredients, an even more excellent whitening effect can be exhibited.

In the present invention, other medicinal ingredients (component (B)) used in combination with the tea extract (component (A))
Are selected from a whitening agent, an active oxygen scavenger, an antioxidant, an anti-inflammatory agent, and an ultraviolet protective agent. Specific examples of the medicinal agent include the following.

(Whitening agent) As a whitening agent, for example,
Gravlidine, glabrene, liquiritin, isoliquiritin and liquorice extract containing them, hydroquinone and its derivatives and salts thereof, cysteine such as N, N'-diacetylcystine dimethyl and its derivatives and salts thereof, L-ascorbic acid, palmitic acid L -Ascorbyl, L-ascorbyl dipalmitate, L-ascorbyl tetrapalmitate, magnesium L-ascorbyl phosphate, sodium L-ascorbyl phosphate, L
-Vitamin C and its derivatives such as disodium ascorbic acid sulfate and their salts, glutathione and its derivatives and their salts, placental extract, resorcin and its derivatives and their salts, ellagic acid and its derivatives and their salts , Syllus extract, syllaceae extract, sage beetle extract, calyx extract, sempens extract, soybean extract, squid extract, squid extract, Clara extract, hawthorn extract, syllaceae extract, hop extract, Neubara extract, Maikaika extract, Gokahi extract, Mokka extract, Brown sugar extract, Wheat germ extract, Cling extract, Yokuinin extract, Taranoki extract, Cowberry extract, Altea extract, Grape seed extract And the like. Among these whitening agents, particularly preferred are vitamin C and its derivatives and salts thereof, hydroquinone and its derivatives and salts thereof, cysteine and its derivatives and salts thereof, glabridine, glabrene, liquiritin, isoliquiritin and the like. Licorice extract and placenta extract.

(Active oxygen scavenger) Examples of the active oxygen scavenger include carotenoids such as SOD, mannitol, beta-carotene, astaxanthin, rutin and derivatives thereof, bilirubin, cholesterol, tryptophan, histidine, quercetin, quercetin Citrine, catechin, catechin derivative, gallic acid, gallic acid derivative, pentagon extract and ginkgo extract, saxifrage extract, melissa extract, ginger extract, buttonpi extract, parsley extract, tormentilla extract, arhat extract, Seaweed extract, Jasagetsu extract, Jicoppi extract and the like can be mentioned. Of these active oxygen removers,
Particularly preferred ones include mannitol, beta-carotene, pentagon extract, and ginkgo extract.

(Antioxidant) Examples of the antioxidant include vitamin A such as retinol acetate and retinol palmitate and derivatives thereof, and salts thereof, riboflavin, pyridoxine, thiamine, nicotinamide, inositol, pantothene. B vitamins such as acids and their derivatives and their salts, cholecalciferol, vitamin D such as ergocalciferol and their derivatives and their salts, dl-α-tocopherol, acetate-dl-α-tocopherol; Linolenic acid-d
Vitamin E such as l-α-tocopherol and its derivatives and their salts, glutathione and its derivatives and their salts, dibutylhydroxytoluene and butylhydroxyanisole. Of these antioxidants, particularly preferred are vitamin E and its derivatives and salts thereof, and dibutylhydroxytoluene.

(Anti-inflammatory agent) Examples of the anti-inflammatory agent include glycyrrhizic acid and / or glycyrrhetinic acid such as dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, stearyl glycyrrhetinate and pyridoxine glycyrrhetinate, and derivatives thereof, and salts thereof.
Mefenamic acid, phenylbutazone, indomethacin, ibuprofen, ketoprofen, allantoin, guaiazulene and their derivatives and their salts, chondroitin sulfate and its salts, ε-aminocaproic acid, diclofenac sodium, acitaba extract, arnica extract, aloe extract , Turmeric extract, hypericum extract, oak extract, chamomile extract, goldfish extract, watercress extract, comfrey extract, salvia extract, sicon extract, perilla extract, birch extract, tea extract, Calendula extract, elderberry extract, asparagus extract, sapling extract, mugwort extract, eucalyptus extract and the like. Among these anti-inflammatory agents, particularly preferred are glycyrrhizic acid, glycyrrhetinic acid,
Guaiazulene and their derivatives and their salts,
ε-aminocaproic acid, aloe extract, sicon extract,
Perilla extract and chamomile extract.

(Ultraviolet ray inhibitor) As an ultraviolet ray inhibitor, paraaminobenzoic acid (hereinafter abbreviated as PABA), PABA ethyl, PABA glyceryl, N, N-
Dimethyl PABA amyl, N, N-dimethyl PABA-
2-ethylhexyl, 2-ethylhexyl salicylate, ethylene glycol salicylate, homomenthyl salicylate, 2-ethylhexyl 4-methoxycinnamate,
Ethoxyethyl 4-methoxycinnamate, potassium 4-methoxycinnamate, methyl 4,5-diisopropylcinnamate, glyceryl mono-2-ethylhexanoate diparamethoxycinnamate, 2-hydroxy-4-methoxybenzophenone 2-hydroxy-4-methoxybenzophenonesulfonic acid, sodium 2-hydroxy-4-methoxybenzophenonesulfonate, 2,2'-dihydroxy-
4,4'-dimethoxybenzophenone, sodium 2,2'-dihydroxy-4,4'-dimethoxybenzophenone-5-sulfonate, 2,4-dihydroxybenzophenone, 2,2 ', 4,4'-tetrahydroxybenzophenone, 2- (2-hydroxy-5-methylphenyl) -benzotriazole, urocanic acid, ethyl urocanate, 4-t-butyl-4'-methoxy-dibenzoylmethane, titanium oxide, zinc oxide, iron oxide and the like. .
Among these UV inhibitors, particularly preferred are homomenthyl salicylate, 2-ethylhexyl 4-methoxycinnamate, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenonesulfonic acid, 2-hydroxy- Sodium 4-methoxybenzophenonesulfonate, 4-t-butyl-4'-methoxy-dibenzoylmethane, titanium oxide, and zinc oxide.

The compounding amount of the above-mentioned component (B) in the whitening external preparation of the present invention varies depending on the type of the drug, but is preferably in the following range. Within this range, when combined with the tea extract of the component (A),
A higher whitening effect can be exhibited without affecting the temporal stability of the preparation and the component (A) in the preparation.

That is, when the whitening agent is blended as the component (B) in the external whitening agent of the present invention, the amount of the whitening agent is preferably 0.000001 to 1%, more preferably 0.000001 to 0.1%. Range. Within this range, a skin external preparation exhibiting a more excellent whitening effect and having a good feeling upon use can be obtained. The same applies to an active oxygen remover, an antioxidant, an anti-inflammatory agent, and the like, which will be sequentially described below. However, when a plant extract or the like is used as an extract, a dry solid content within this range may cause a problem. Absent.

In the whitening external preparation of the present invention, (B)
When the active oxygen remover is compounded as a component,
Preferably 0.000001 to 1%, more preferably 0.001%.
It is in the range of 00001 to 0.1%. Within this range, a skin external preparation exhibiting a more excellent effect of removing active oxygen and exhibiting an excellent whitening effect can be obtained.

Further, in the whitening external preparation of the present invention, (B)
When the antioxidant is added as a component, the amount is preferably 0.000001 to 1%, more preferably 0.000%.
The range is from 01 to 0.1%. Within this range, a more excellent antioxidant effect can be obtained, and a skin external preparation exhibiting an excellent whitening effect can be obtained.

Furthermore, when the anti-inflammatory agent is blended as the component (B) in the whitening external preparation of the present invention, the amount is preferably 0.000001 to 1%, more preferably 0.000001 to 0%. .1% range. Within this range, an external preparation for skin which exhibits an excellent anti-inflammatory effect and an excellent whitening effect can be obtained.

Furthermore, when the ultraviolet light inhibitor is added as the component (B) in the whitening external preparation of the present invention, the compounding amount is preferably 0.01 to 20%, more preferably 0.1 to 15%. Range. Within this range, a skin external preparation that exhibits a more excellent ultraviolet ray preventing effect and also has an excellent whitening effect can be obtained.

The above whitening agents, active oxygen scavengers, antioxidants, anti-inflammatory agents, and ultraviolet inhibitors can be used alone or in combination of two or more.

The whitening external preparation combining the above components (A) and (B) is an essential component (A) according to a conventional method.
The component and the component (B) can be prepared by formulating and formulating a base in various forms known as ordinary skin external preparations according to a conventional method.

Examples of the form of the whitening external preparation of the present invention include:
There is no particular limitation. For example, cosmetics such as milky lotions, creams, lotions, packs, detergents, foundations, white powders and the like, quasi-drugs, dispersions, ointments, creams, and topical medicines such as topical solutions can be used. .

Depending on the form of the whitening external preparation, in addition to the above-mentioned essential components, components usually used in external skin preparations such as cosmetics and pharmaceuticals, for example, purified water, lower alcohols, polyhydric alcohols, fats, waxes, mineral oils , Fatty acids, powders, metal soaps, pH adjusters, surfactants, thickeners, pigments, extracts derived from plant or animal raw materials, vitamins, amino acids, hormones, fungicides, preservatives, keratolytic agents Enzymes, cooling agents, stabilizers, metal ion chelators, blood circulation promoters, essential oils, deodorants, humectants, fragrances, and the like can be used as appropriate.

[0030]

EXAMPLES Next, the present invention will be described in more detail with reference to Production Examples, Reference Examples, Test Examples and Examples, but the present invention is not limited thereto.

Production Example 1 Production of bean tea extract: 10 g of dried bean tea, water content of 5 g
100 mL of 0 vol% ethyl alcohol was added, extraction was performed at room temperature for 3 days, and then filtration was performed to obtain a tea extract. At this time, the dry solid content of the tea extract was 3.0%.

REFERENCE EXAMPLE 1 Production of Sohakuhoku extract: 10 g of Sohakuhoku (JP)
And ethyl alcohol 100 with a water content of 50 vol%
mL was added, extraction was performed at room temperature for 3 days, and then filtration was performed to obtain a sow swallow extract. At this time, the dry solids content of the sow mushroom extract was 1.8%.

Test Example 1 Test for suppression of melanin production by cultured cells An appropriate amount of the medium was collected in two 6-well dishes, and mouse-derived B
16 melanoma cells are inoculated and left at 37 ° C. in a carbon dioxide concentration of 5%. On the next day, the bean tea extract obtained in Production Example 1 and the soybean extract obtained in Reference Example 1 are added and mixed into this medium so that the final concentrations are 1, 10, and 100 μg / mL. Change the medium on the 5th day of culture,
Add again the same solution that was originally added. On the next day, the medium was removed, the cells were washed with a phosphate buffer in one petri dish, and collected, and the whitening degree of the cultured B16 melanoma cells was visually evaluated according to the following criteria.

(Criterion for determining whitening degree) <Judgment> <Contents> ++: extremely white with respect to the control. +: Clearly white with respect to the control. ±: slightly white with respect to the control. -: The same black color as the control.

For the remaining one petri dish, the cells were fixed in formalin and stained by adding a 1% crystal violet solution. The number of surviving cells (A) and the number of control cells (B) for each sample concentration were measured using a monocellulator, and the cell viability was calculated using Equation 1. Table 1 shows the above results.

[0036]

(Equation 1)

(Result)

[Table 1]

As is clear from the above results, Production Example 1
It was confirmed that the bean tea extract obtained in Example 1 had a high melanin-suppressing action and low toxicity to cells.

Example 1 Whitening Effect Test: A cream was prepared according to the composition shown in Table 2 and the following method, and the whitening effect was examined. The results are also shown in Table 2.

(Composition and results)

[Table 2]

(Production method) A. Components (1) to (6) and (11) to (13) are mixed and heated to 70 ° C. B. Heat component (15) to 70 ° C. C. Add B to A, mix and cool. D. Add components (7) to (10) and (14) to C,
I got a cream.

(Test Method) 2 per test cream
A panel of 15 women aged 8-55 years
After washing the face for 12 weeks, an appropriate amount of the test cream was applied to the face. After the coating test, the whitening effect of the coating was evaluated according to the following criteria.

(Evaluation Criteria for Whitening Effect) <Evaluation> <Contents> Effective: The dullness of the skin became less noticeable. Slightly effective: Skin dullness became less noticeable. Ineffective: No change from before use.

As shown in the results in Table 2, the products 1 to 5 of the present invention
The cream containing the bean tea extract and the medicinal agent obtained in Production Example 1 represented by No. 6 can prevent and improve the occurrence of “dullness” on the skin by applying these to the skin, and is beautiful. It turned out to be skin.

Example 2 Cosmetic lotion: A lotion was prepared by the following composition and production method. (Composition) (Mass%) (1) Tengcha extract ^{* 1} 2.0 (2) Licorice extract ^{* 2} 0.5 (3) Ginkgo extract ^{* 3} 0.01 (4) Glycerin 5.0 ( 5) 1,3-butylene glycol 6.5 (6) polyoxyethylene (20EO) sorbitan 1.2 monolaurate ester (7) ethyl alcohol 8.0 (8) preservative appropriate amount (9) fragrance appropriate amount ( 10) Remaining purified water * 1 Manufactured in Production Example 1 * 2 Maruzen Pharmaceutical * 3 Tokiwa Plant Chemicals

(Production method) A. Components (6) to (9) are mixed and dissolved. B. Components (1) to (5) and (10) are mixed and dissolved. C. A and B were mixed and made uniform to obtain a lotion.

Example 3 Emulsion: An emulsion was prepared by the following composition and production method. (Composition) (Mass%) (1) Polyoxyethylene (10EO) Sorbitan 1.0 monostearate (2) Polyoxyethylene (60EO) Sorbit 0.5 Tetraoleate (3) Glyceryl monostearate 1.0 (4) Stearic acid 0.5 (5) Behenyl alcohol 0.5 (6) Squalane 8.0 (7) 4-Ethylhexyl 4-methoxycinnamate ^{* 1} 2.0 (8) Tengcha extract ^{* 2} 3.0 (9) Dipotassium glycyrrhizinate ^{* 3} 0.5 (10) Carboxyvinyl polymer 0.1 (11) Sodium hydroxide 0.05 (12) Ethyl alcohol 5.0 (13) Preservative Appropriate amount (14) Perfume Appropriate amount (15) Residual amount of purified water * 1 BASF * 2 Manufactured in Production Example 1 * 3 Maruzen Pharmaceutical

(Production method) A. Components (1) to (7) and (13) were mixed by heating.
Keep at 0 ° C. B. Components (9) to (12) and (15) are mixed by heating,
Keep at 70 ° C. C. Add A to B, mix and emulsify uniformly. After cooling DC, (8) and (14) were added, and the mixture was uniformly mixed to obtain an emulsion.

Example 4 Cream: A cream was prepared by the following composition and production method. (Preparation) (mass%) (1) Polyoxyethylene (40EO) monostearate 2.0 (2) Glycerin monostearate (self-emulsifying type) 5.0 (3) Stearic acid 5.0 (4) behenyl alcohol 0.5 (5) squalane 15.0 (6) cetyl isooctanoate 5.0 (7) preservative appropriate amount (8) 1,3-butylene glycol 5.0 (9) bean tea extract ^{* 1} 1.0 (10) Remaining amount of purified water (11) Appropriate amount of fragrance * 1 Manufactured in Production Example 1

(Production Method) A. Components (1) to (7) are heated and dissolved at 70 ° C. B. Heat components (8) and (10) to 70 ° C. C. Add A to B and, while cooling, ingredients (9), (11)
Was added to obtain a cream.

Example 5 Cream: A cream was prepared by the following composition and production method. (Preparation) (mass%) (1) Polyoxyethylene (40EO) monostearate 2.0 (2) Glycerin monostearate (self-emulsifying type) 5.0 (3) Stearic acid 5.0 (4) Behenyl alcohol 0.5 (5) Squalane 15.0 (6) Cetyl isooctanoate 5.0 (7) 2-Ethylhexyl 4-methoxycinnamate ^{* 1} 3.0 (8) Stearyl glycyrrhetinate ^{* 20} .2 (9) 1,3-butylene glycol 5.0 (10) Tengcha extract ^{* 3} 0.5 (11) Perilla extract ^{* 4} 0.5 (12) Placenta extract ^{* 5} 0.5 (13) Appropriate perfume (14) Preservatives Appropriate (15) Residual amount of purified water * 1 BASF * 2 Maruzen * 3 Manufactured in Production Example 1 * 4 Maruzen * 5 Nichirei

(Production method) A. Components (1) to (9) and (14) are heated and dissolved at 70 ° C. B. Heat components (9) and (15) to 70 ° C. C. Add A to B and cool. D. Components (10) to (13) were added to C to obtain a cream.

Example 6 Ointment: An ointment was prepared by the following composition and production method. (Preparation) (mass%) (1) Stearic acid 18.0 (2) Cetanol 4.0 (3) Triethanolamine 2.0 (4) Glycerin 5.0 (5) Teng tea extract ^{* 1} 5. 0 (6) Hop extract ^{* 2} 1.0 (7) Magnesium L-ascorbyl phosphate ^{* 3} 1.0 (8) Sodium 2-hydroxy-4-methoxybenzophenone sulfonate ^{* 4} 0.05 (9) Purification Water remaining * 1 Manufactured in Production Example 1 * 2 Maruzen Pharmaceutical * 3 Yoshitomi Pharmaceutical * 4 Merck

(Production method) A. A part of the components (3), (4) and (8), (9) are mixed by heating and kept at 75 ° C. B. Components (1) and (2) are mixed by heating and kept at 75 ° C. C. Add A slowly to B. While cooling DC, the components (5), (6) and (7) dissolved in the remainder of (9) were added to obtain an ointment.

Example 7 Gel ointment: A gel ointment was prepared by the following composition and manufacturing method. (Preparation) (mass%) (1) Carboxyvinyl polymer 1.0 (2) Triethanolamine 1.0 (3) Ethyl alcohol 20.0 (4) Teng tea extract ^{* 1} 3.0 (5) Purification Water residue (6) Retinol palmitate ^{* 2} 1.0 (7) L-ascorbyl tetrapalmitate ^{* 3} 1.0 (8) 2-Hydroxy-4-methoxybenzophenone ^{* 4} 0.05 * 1 Production Example 1 * 2 Nippon Roche * 3 Nippon Surfactant * 4 Wako Pure Chemical

(Production method) A. Components (1), (2) and (4), (5) are mixed by heating and kept at 75 ° C. B. Components (3), (6) to (8) are heated and mixed, and the mixture is heated to 75 ° C.
To keep. C. A was gradually added to B and cooled to obtain a gel ointment.

The lotion of Example 2, the lotion of Example 3, the cream of Examples 4 and 5, the ointment of Example 6, and the gel ointment of Example 7 are all applied to the skin, In addition to preventing the occurrence of "dullness" and the like, pigmentation such as spots and the like can be improved, and the skin has a beautiful, transparent feeling.

Example 8 Pack: A pack was prepared by the following composition and manufacturing method. (Preparation) (mass%) (1) Polyvinyl alcohol 20.0 (2) Ethyl alcohol 20.0 (3) Glycerin 5.0 (4) Kaolin 6.0 (5) Teng tea extract ^{* 1} 1.0 (6) Aloe extract ^{* 2} 3.0 (7) Seaweed extract ^{* 3} 1.5 (8) Preservative 0.2 (9) Fragrance 0.1 (10) Remaining amount of purified water * 1 In Production Example 1 Manufactured * 2 Maruzen Pharmaceutical * 3 Maruzen Pharmaceutical

(Preparation Method) A. Components (1), (3), (4) and (10) are mixed, heated to 70 ° C. and stirred. B. Mix components (2) and (8). C. The above B was added to the above A, mixed, cooled, and the components (5) to (7) and (9) were uniformly dispersed to obtain a pack.

By applying the pack obtained in Example 8 to the skin, the texture of the skin can be adjusted, the occurrence of “dullness” on the skin can be prevented, and the pigmentation such as spots can be improved. It was intended to make the skin transparent and beautiful.

Example 9 Liquid foundation: A liquid foundation was prepared by the following composition and production method. (Preparation) (mass%) (1) Lanolin 7.0 (2) Liquid paraffin 5.0 (3) Stearic acid 2.0 (4) Cetanol 1.0 (5) Glycerin 5.0 (6) Tri Ethanolamine 1.0 (7) Carboxymethylcellulose 0.7 (8) Remaining purified water (9) Mica 15.0 (10) Talc 6.0 (11) Titanium oxide 3.0 (12) Color pigment 6.0 (13) Teng tea extract ^{* 1} 0.05 (14) Yokuinin extract ^{* 2} 0.05 (15) beta-carotene ^{* 3} 0.01 (16) Flavor appropriate amount * 1 Produced in Reference Example 1 * 2 Maruzen Pharmaceutical * 3 Sigma

(Preparation Method) A. Components (1) to (4) and (15) are mixed and heated to 70 ° C. B. Add components (9) to (12) to A and mix uniformly. C. Components (5) to (8) are uniformly dissolved and kept at 70 ° C. D. Add C to B and emulsify uniformly. E. After cooling D, components (13), (14) and (16)
Was added to obtain a liquid foundation.

By applying any of the liquid foundations obtained in Example 9 to the skin, it is possible to prevent the occurrence of “dullness” on the skin and to improve the pigmentation of stains and the like. It was intended to make the skin beautiful and rich.

[0064]

The bean tea extract used as a whitening agent in the present invention has a whitening effect such as a melanin inhibitory effect. Therefore, a whitening external preparation containing the same exhibits a high inhibitory effect on melanin production and skin pigmentation, is effective in preventing and improving skin darkening due to sunburn, spots, freckles, etc. It is extremely useful in medicine.

Further, in addition to this bean tea extract, the skin external preparation of the present invention containing other medicinal ingredients such as a whitening agent, an active oxygen remover, an antioxidant, an anti-inflammatory agent, and an ultraviolet inhibitor is the same as the extract described above. Shows a more excellent whitening effect and the like as compared with the case where is blended alone. that's all

Continued on the front page (51) Int.Cl. ⁷ Identification code FI Theme coat II (Reference) A61P 17/00 A61P 17/00 (72) Inventor Kumi Kameyama 48-18 Sakaemachi, Kita-ku, Tokyo COSE CORPORATION Research Division F term (for reference) 4C083 AA071 AA072 AA082 AA111 AA112 AB032 AB211 AB231 AB241 AB242 AB432 AB442 AC022 AC031 AC072 AC102 AC122 AC131 AC182 AC211 AC242 AC311 AC341 AC342 AC422 AC442 AC471 AC472 AC542 AC551 AC581 AD621 AC1 AD1 AD 842 AD 842 AD512 AD531 AD532 AD621 AD622 AD631 AD641 AD642 AD651 AD661 AD662 BB46 BB47 BB51 CC02 CC04 CC05 CC07 CC12 DD22 DD23 DD27 DD31 DD41 EE16 4C088 AA12 AB02 AB12 AB13 AB15 AB17 AB25 AB26 AB29 AB38 AB40 AB41 AB43 AB44 AB73 AB81 AB85 AB86 AC05 MA63 NA03 NA05 ZA89 ZC75

Claims (8)

[Claims] 1. A whitening agent comprising a tea extract as an active ingredient. 2. A whitening preparation for external use, characterized by containing a tea extract. 3. The following components (A) and (B): (A) bean tea extract (B) whitening agent, active oxygen remover, antioxidant, anti-inflammatory agent,
An external whitening agent characterized by containing one or more kinds of medicinal agents selected from ultraviolet inhibitors. 4. The whitening agent of the component (B) is glabridine,
Gravurene, liquiritin, isoliquiritin and liquorice extract containing them, hydroquinone and its derivatives and salts thereof, cysteine and its derivatives and their salts, ellagic acid and its derivatives and their salts, vitamin C and its derivatives and their salts, Glutathione and its derivatives and their salts, placenta extract, resorcinol and its derivatives and their salts, syllus extract, juniper extract, sempukuka extract, calyx extract, sampens extract, soybean extract, and ibis extract, Ibukitrano extract, Clara extract, Hawthorn extract, Shirahuri extract, Hop extract, Neubara extract, Maikaika extract, Gokahi extract, Mokka extract, Brown sugar extract, Wheat germ extract, Intinko extract , Yokuinin extract Things, Aralia elata extract, bilberry extract, whitening external preparation as described third claims is a member selected from Altea extract and grape seed extract. 5. The method according to claim 1, wherein the active oxygen remover of component (B) is SO.
D, mannitol, carotenoids such as beta-carotene, astaxanthin, rutin and its derivatives, bilirubin, cholesterol, tryptophan, histidine,
Quercetin, quercitrin, catechin, catechin derivatives, gallic acid, gallic acid derivatives, pentagon extract, ginkgo extract, saxifrage extract, melissa extract, genoshoko extract, botanpi extract, parsley extract,
The whitening external preparation according to claim 3, which is selected from a tormentilla extract, an arhat extract, a seaweed extract, a yasazitsu extract and a jikkopi extract. 6. The antioxidant of the component (B) is a vitamin A, a derivative thereof, a salt thereof, a vitamin B, a derivative thereof, a salt thereof, a vitamin D, a derivative thereof, and a salt thereof. The whitening external preparation according to claim 3, which is selected from vitamin E and its derivatives and salts thereof, dibutylhydroxytoluene and butylhydroxyanisole. 7. The anti-inflammatory agent of the component (B) may be glycyrrhizic acid, glycyrrhetinic acid, mefenamic acid, phenylbutazone, indomethacin, ibuprofen, ketoprofen, allantoin, guaiazulene, a derivative thereof, a salt thereof, chondroitin sulfate or a salt thereof. Salt, ε
-Aminocaproic acid, diclofenac sodium, ashitaba extract, arnica extract, aloe extract, turmeric extract, hypericum extract, oak extract, chamomile extract, goldfish extract, watercress extract, comfrey extract, salvia extract Stuff, siconium extract, perilla extract, birch extract, tea extract, calendula extract, elder extract, elephant extract, sapling extract,
The whitening external preparation according to claim 3, which is selected from a mugwort extract and a eucalyptus extract. 8. The ultraviolet ray inhibitor of the component (B) is paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl N, N-dimethylparaaminobenzoate, N, N-dimethylparaaminobenzoic acid-2-.
Ethylhexyl, 2-ethylhexyl salicylate, ethylene glycol salicylate, homomenthyl salicylate, 2-ethylhexyl 4-methoxycinnamate, 4-
Ethoxyethyl methoxycinnamate, potassium 4-methoxycinnamate, methyl 4,5-diisopropylcinnamate,
Glyceryl mono-2-ethylhexanoate diparamethoxycinnamate, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenonesulfonic acid, sodium 2-hydroxy-4-methoxybenzophenonesulfonate, 2,2 '-Dihydroxy-4,4'
-Dimethoxybenzophenone, 2,2'-dihydroxy-
Sodium 4,4'-dimethoxybenzophenone-5-sulfonate, 2,4-dihydroxybenzophenone,
2 ', 4,4'-tetrahydroxybenzophenone, 2-
(2-hydroxy-5-methylphenyl) -benzotriazole, urocanic acid, ethyl urocanate, 4-t
The whitening external preparation according to claim 3, which is selected from -butyl-4'-methoxy-dibenzoylmethane, titanium oxide, zinc oxide and iron oxide.