JPH04342519A - Skin cosmetic - Google Patents

Abstract

PURPOSE:To obtain a skin cosmetic having excellent beautifying effects, improved safety and stability free from problems of color, smell, etc., containing an extract of galenical drug derived from specific leguminous and compositus plant having high inhibitory action on tyrosinase activity. CONSTITUTION:A skin cosmetic containing preferably about 0.01-5.0wt.% calculated as dried solid content of one or more extracts obtained by extracting a galenical drug selected from SANZUKON (root of Sophora subprosarata), GOKANHI (bark of Albizzia julibrissin), SANHENZU (C. sophera L.), SOJISHI (Xanthium strumarium L.), SHION (root of Aster tataricus) and INCHINKOU (whole grass of Artemisia capillaris) with one of water, ethyl alcohol, glycerol and 1,3-butylene glycol or a mixed solvent of two or more of them at room temperature or under heating. The cosmetic has excellent beautifying effects, inhibitory action on skin aging and improving effects on chapped skin. The cosmetic can be made into a dosage form such as toilet lotion, milky lotion, cream, pack, ointment, dispersion, cleaning agent, etc.

Description

[Detailed description of the invention]

0001

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to skin cosmetics containing extracts of herbal medicines derived from specific leguminous and asteraceous plants, which have excellent whitening effects, skin aging prevention effects, skin roughness improvement effects, etc.

0002

[Prior art and problems to be solved by the invention] Conventionally,
Whitening cosmetics mainly contain ascorbic acid, glutathione, colloidal sulfur, etc., and these whitening cosmetics are extremely useful in obtaining beauty effects such as preventing dark skin, age spots, and freckles. However, since ascorbic acid is easily oxidized, not only is it difficult to expect a certain effect, but the cosmetic itself may change color. Furthermore, glutathione and colloidal sulfur have drawbacks such as a peculiar odor and precipitation depending on the dosage form.

[0003] Recently, attempts have also been made to obtain whitening effects by incorporating natural products such as crude drugs into cosmetics (Japanese Patent Application Laid-open Nos. 88333-1983, 2344-1980, 2003-1983). No. 57-163307, JP-A No. 60-104005, Fragrance Journal Extra Edition No. 6 (19
86) p164-166). Although these herbal medicines are expected to be useful because of their high safety, their whitening effects are still insufficient.

[0004]Therefore, it has been desired to develop skin cosmetics containing crude drugs that have excellent whitening effects and have no problems with safety, color, odor, etc.

[0005]

[Means for Solving the Problems] In view of the above-mentioned circumstances, the present inventors have conducted extensive research on the whitening effect, etc. of extracts of crude drugs, and have found that extracts of crude drugs derived from specific Fabaceae and Asteraceae plants. They have found that they have a high tyrosinase activity inhibiting effect, and that cosmetics containing them have excellent whitening effects, as well as safety and stability, and have completed the present invention.

That is, the present invention provides a skin characterized by containing one or more extracts of herbal medicines selected from mountain bean root, hehuanpi, mountain bean, cang'erzi, ziongian and 茵chinchiang. It provides cosmetics.

[0007] The preparation method of the herbal medicine extract obtained from wild bean root, hehuanpi, mountain bean, cang'uizhi, purple onion, and 茵chinchiang used in the skin cosmetics of the present invention is not particularly limited, but for example, various suitable methods can be used. Extracted using a suitable solvent at room temperature to elevated temperature. Extraction solvents include, for example, water; lower monohydric alcohols such as methyl alcohol and ethyl alcohol; liquid polyhydric alcohols such as glycerin, propylene glycol, and 1,3-butylene glycol; lower alkyl esters such as ethyl acetate; benzene, hexane, etc. hydrocarbons; one or more of ethers such as diethyl ether can be used. Among these, water or a water-soluble solvent, particularly one or a mixed solvent of two or more of water, ethyl alcohol, glycerin, and 1,3-butylene glycol, is preferred. In addition, the extraction conditions are 1 to 1000 times the volume of the crude drug, especially 5 to 1000 times the volume of the crude drug.
Using 100 times the amount of solvent, at 4°C or higher, especially at 15 to 30°C
It is preferable to carry out the treatment at a temperature of 1 hour or more, particularly for 1 to 3 days.

[0008] The crude drug extract obtained under the above conditions may be used as it is as an extracted solution, but it can also be used after further treatment such as concentration and filtration if necessary.

[0009] All of the above herbal medicine extracts in the present invention have a whitening effect, but in addition to this, the extracts of mountain bean and Chinese chinensis also have an anti-aging effect on the skin and an effect on improving rough skin due to active oxygen scavenging action. have Therefore, the above-mentioned herbal medicine extracts are incorporated into skin cosmetics that are expected to have these effects.

[0010] The content of the herbal medicine extract in the skin cosmetic of the present invention is 0.0001 to 10.0% in terms of dry solid content.
0% by weight is preferred, and a range of 0.01 to 5.0% by weight is particularly preferred. If the content is less than 0.0001% by weight, the effect will not be sufficiently exhibited, and if the content exceeds 10.0% by weight, the effect will be almost constant.

[0011] In addition to the above-mentioned essential ingredients, the skin cosmetic of the present invention contains aqueous ingredients, powders, surfactants, oils, moisturizers, alcohol, and pylori, which are commonly used in cosmetics, quasi-drugs, and pharmaceuticals.
It is prepared by appropriately blending H regulators, preservatives, antioxidants, thickeners, pigments, fragrances, etc. as necessary.

The dosage form of the skin cosmetic of the present invention is not particularly limited, and may include lotions, milky lotions, creams, packs, ointments, dispersions,
It can be made into various formulations such as cleaning agents.

[0013] Furthermore, the skin cosmetic of the present invention may further contain known drugs if necessary. Examples of the drug include drugs having a whitening effect such as ascorbic acid, glutathione and their respective derivatives, placenta extract, toki extract, mulberry bark extract, and aloe extract;
Anti-inflammatory agents such as glycyrrhetinic acid and its derivatives, indomethacin; UV absorbers such as urocanic acid, benzophenone, para-aminobenzoic acid, cinnamic acid and their respective derivatives; antioxidants such as vitamin E, rosemary extract, tea extract, etc. etc. These drugs may be used alone or in combination of two or more.

[0014]

EXAMPLES Next, the present invention will be explained in more detail with reference to test examples and examples, but the present invention is not limited thereto.

Test Example 1 Tyrosinase activity inhibition test: 80 parts by weight of extraction solvent was added to 20 parts by weight of each dried herbal medicine shown in Table 1, and the mixture was stirred occasionally at room temperature for 3 hours.
The extracts were extracted for several days and filtered to obtain extracts of each crude drug. Using each of these crude drug extracts as samples, the inhibition rate of tyrosinase activity was measured by the following measurement method. The results are shown in Table 1. <Measurement method> Add 10 mg of tyrosinase (manufactured by Sigma, 28,000 units) to 0.1 to 0.2 ml of each sample.
．． Add 0.1 ml of the solution dissolved in 20 ml of 1M phosphate buffer (pH 6.8), and add 0.1M phosphate buffer (pH 6.8) to make 4 ml.
Incubated for 0 minutes. Add this to 25℃ in advance.
Substrate solution [L-DOPA (Tokyo Kasei) 1
98.0 mg in 0.1 M phosphate buffer (pH 6.8) 1
1.0 ml of the solution] was added and reacted for 10 minutes. Then the absorbance at 475 nm (OD
S ) was measured. Furthermore, the absorbance (ODHE) of a similar reaction using the heat-inactivated enzyme and the absorbance (ODB) when no sample was added were measured, and the inhibition rate of tyrosinase activity was calculated from the following formula.

[0016]

[Math 1]

[0017]

[Table 1]

[0018] As is clear from the results in Table 1, the extracts of wild bean root, hehuanpi, mountain bean, cang'erzi, purple onion, and chinchen used in the present invention inhibit tyrosinase and inhibit the production of dopachrome. It had a high whitening effect.

Test Example 2 Active oxygen removal effect test:
Ethyl alcohol, 50% (v/v) aqueous ethyl alcohol solution, or 80 parts by weight of water was added to 20 parts by weight of each dried crude drug shown in Table 2, extracted with occasional stirring for 3 days at room temperature, and filtered. Extracts of each crude drug were obtained. Using each of these herbal medicine extracts as samples, the active oxygen removal rate was measured by the following measurement method. The results are shown in Table 2. <Measurement method> 0.05M sodium carbonate buffer (pH 1
0.2) Add 0.1m of substrate solution [3.0mM xanthine (dissolved in 0.05M sodium carbonate buffer)] to 2.4ml.
l, 3.0mM EDTA 0.1ml, 0.15% (
w/v) bovine serum albumin 0.1ml, 0.75mM
Mix 0.1 ml of nitro blue tetrazolium and 0.1 ml of each sample, leave to stand at 25°C for 10 minutes, and dilute the enzyme solution [xanthine oxidase solution (approx.
．． 0.04 units/ml dilution)] to start the reaction. After incubating for 20 minutes at 25°C, the reaction is stopped by adding 0.1 ml of 6mM CuCl2. The absorbance (A) at 560 nm is then measured. For the control, the absorbance (B) was obtained by adding purified water instead of the sample, and for each sample blank, 6mM CuC
After 0.1 ml of 12 was added to stop the reaction, 0.1 ml of xanthine oxidase was added, the absorbance (C) was measured, and the active oxygen removal rate was calculated from the following formula.

[0020]

[Math 2]

[0021]

[Table 2]

[0022] As is clear from the results in Table 2, the extracts of mountain bean and Chinese bean used in the present invention remove active oxygen,
It had high SOD-like antioxidant activity.

Example 1 Lotion: <Composition>


(Weight%) (1) Glycerin

5.0(2) 1,3-butylene glycol
4.0(3) Oleyl alcohol
0.1(4) Polyoxyethylene sorbitan monolaurate
(20E.O.)

1.5(5) Polyoxyethylene lauryl ether (20E.O.)
0.5(6) Ethyl alcohol

10.0(7) Sorbitol
1.
0(8) Wild bean root 50% ethyl alcohol extract *1
0.5 (9
) vitamin E

0.1 (10) Oxybenzone

0.2 (11) Preservative

Appropriate amount (12)
fragrance

Appropriate amount (13) Purified water

Remaining amount meter


100.0*1: Contains about 8% dry solid content of wild bean root extract (from Test Example 1) <Production method> A. (3) to (6) and (9) to (12) are mixed and dissolved. B. Mix and dissolve (1), (2), (7), (8) and (13). C. Mix A and B until uniform.

Example 2 Cream: <Composition>


(Weight%) (1) Beeswax

6.0(2) Setanol
5.
0(3) Reduced lanolin

8.0(4) Squalane

37.5(5) Glycerin monostearate
4.0(6) Lipophilic glyceryl monostearate
2.0(7) Polyoxyethylene sorbitan monolaurate (20E.O.)
2.0(8) Hehuanpi water extract*
2
3.0(9) Preservatives

Appropriate amount (10) Fragrance

Appropriate amount (11) 1,3-butylene glycol
5.0 (12) Purified water

Remaining amount
total

100.0*2: Contains about 5% dry solid content of Hehuanpi extract (from Test Example 1) <Manufacturing method> A. Mix (1) to (7) and (9) to (10), heat and maintain at 70°C. B. Mix (8), (11) and (12), heat and maintain at 70°C. C. Add A to B, emulsify uniformly, and cool to 30°C.

Example 3 Pack: <Composition>


(Weight%) (1) Polyvinyl alcohol

15.0(2) Sodium carboxymethylcellulose
5.0(3) Propylene glycol

3.0 (4) Mountain bean 1,3-butylene glycol extract *3
2.5(5) Ethyl alcohol

10.0(6) Urocanic acid

0.1 (7) Preservative

Appropriate amount (8) Fragrance

Appropriate amount (9) Purified water

Remaining amount
total

100.0*3: Contains about 9% dry solid content of mountain bean extract (obtained in the same manner as Test Example 1) <Production method> A. Mix (1) to (4), (6) and (9), 70
Heat to ℃ and dissolve while stirring. B. Mix (5), (7) and (8). C. Add B to A, mix, and then cool.

Example 4 Emulsion: <Composition>

(Weight%) (1) Squalane

5.0(2)
Vaseline

2.0 (3) Beeswax

0.5(4) Sorbitan sesquioleate ester
0.8(5) Polyoxyethylene oleyl ether (20E.O.)
1.2(6) 1,3-butylene glycol

5.0 (7) Blueberry ether extract *4 (as dry solid content)

0.05(8) Ethyl alcohol

5.0(9) Preservatives

Appropriate amount (10
)Fragrance

Appropriate amount (11) carboxyvinyl polymer (1.0
% aqueous solution) 20.0 (12)
potassium hydroxide
0
．． 1 (13) Purified water

Remaining amount meter

100
．． 0*4: Extracted and dried in the same manner as in Test Example 1 <Production method> A. (6) to (8) and (13) were heated and mixed at 70°C.
Keep it. B. (1) to (5), (9) and (10) are heated and mixed and kept at 70°C. C. Add B to A, mix, then add (11) and mix uniformly, add (12) and emulsify uniformly, then 30°C
Cool until cool.

Test Example 3 Usage Effect Test: The skin whitening effect of the skin cosmetic of the present invention was tested by use test. The usage test was conducted using a panel of 15 women aged 30 to 40, who applied an appropriate amount of the test cosmetic to their faces twice a day, once in the morning and once in the evening, after washing their faces for two weeks. The test cosmetics were the cream of Example 2, the milky lotion of Example 4, and the control product manufactured in the same manner as in Example 2 except that (8) Hehuan skin water extract of the cream of Example 2 was removed and the correction was made with purified water. was used. The results are shown in Table 3. Note that the evaluation was performed based on the following criteria.・Effective whitening effect: Spots and freckles are almost invisible. Slightly effective: Spots and freckles are less noticeable. Invalid: No change.

[0028]

[Table 3]

As is clear from the results in Table 3, Example 2
The use of the cream of Example 4 and the emulsion of Example 4 was confirmed to have a high effectiveness rate in making spots and freckles less noticeable. In addition, the lotion of Example 1 and Example 3
We conducted almost the same usage test for the pack and found similar results.

Example 5 Same as in Example 1 except that 0.5% of 50% ethyl alcohol extract of mountain bean (containing about 7% dry solid content of mountain bean extract) was added as component (8). Then I got the lotion.

Example 6 As component (8) of Example 2, 3.0% of the water extract of mountain bean (containing about 6% of mountain bean extract as dry solid content) was used.
A cream was obtained in the same manner except that % was added.

Example 7 As the component (4) of Example 3, 3.0% of the 1,3-butylene glycol extract (containing 6% of the dry solid content of the Trifolium chinensis extract) was blended. Other than that, I got the pack in the same way.

Example 8 As the component (7) of Example 4, 0.
．． A milky lotion was obtained in the same manner except that 0.3% (as dry solid content) was blended.

Test Example 4 Usage Effect Test: The skin cosmetic composition of the present invention was tested for its anti-aging effect and skin roughness improvement effect through a use test. Usage test is 30
A panel of 20 women aged 55 to 55 years old applied the test cosmetics to their faces twice a day, once in the morning and once in the evening, for 12 weeks after washing their faces. The test cosmetic was Example 6.
Control products were used that were manufactured in the same manner as in Example 6, except that (8) Yamabian bean water extract of the cream of Example 8, the milky lotion of Example 8, and the cream of Example 6 was removed and corrected with purified water. Table 4 shows the results.
Shown below. Note that the evaluation was performed based on the following criteria.・Effective in preventing skin aging: Improved skin firmness and luster. Slightly effective: Skin firmness and luster were slightly improved. Invalid: No change from before use.・Effective for improving rough skin Effectiveness: The dryness and roughness of the skin has been improved. Slightly effective: Skin dryness and roughness were slightly improved. Invalid: No change from before use.

[0035]

[Table 4]

As is clear from the results in Table 4, Example 6
The cream of Example 8 and the emulsion of Example 8 were effective in preventing skin aging and against rough skin.

[0037]

EFFECTS OF THE INVENTION As detailed above, the skin cosmetics of the present invention have excellent whitening effects and can be widely applied to prevent and improve skin darkening, age spots, and freckles caused by sunburn. In particular, the skin cosmetics of the present invention containing mountain bean and chinensis extracts exhibit excellent effects in preventing skin aging and rough skin in addition to the above-mentioned effects. Furthermore, the skin cosmetics of the present invention are stable and safe, so they can be used with confidence.

Claims (1)

[Claims] 1. A skin cosmetic containing one or more extracts of herbal medicines selected from wild bean root, hehuanpi, mountain bean, cang'erzi, purple onion, and 茵chinchiang.