JPH04338313A - Cosmetic - Google Patents

Abstract

PURPOSE:To obtain a cosmetic having skin conditioning effects, improving hair roughness and chapped skin. CONSTITUTION:A cosmetic containing one or more solvent extracts selected from Cassia alata L., Piper returofuraotaum L., Euphorbia pilulifera L., Celeus scutellai oiders Benth., Cryptocarya aromatica Kostem, Curcuma heyneana val. et z. Zjip, Trygonella foenum-gracecum, crude drugs of plant. A water-soluble solvent such as water, ethanol and 1,3-butylene glycol are used as the solvent. A basic cosmetic such as cream, lotion, milky lotion and pack, a make-up cosmetic such as foundation and lipstick, a hair cosmetic such as hair cream, hair lotion, shampoo and rinse and an agent form such as bathing agent and soap may be adopted as the cosmetic.

Description

Detailed Description of the Invention [0001] [Industrial Application Field] The present invention provides a cosmetic product characterized by containing a crude drug extract having anti-inflammatory action, superoxide scavenging action, and/or antibacterial action. Regarding. [Prior Art] Cassia alata, Piper litroflatum, Euphorbia pyrulifera, Coleus scutellaoides, Cryptocarya aromatica, Curcuma haineana, and Trigonella whenumgraecum are used in folk medicine in Indonesia for eye treatment, etc. It is a plant medicine that is used. However, their physiological activities, such as anti-inflammatory action, superoxide scavenging action, and antibacterial action, have not been clarified. On the other hand, since inflammation caused by ultraviolet rays and the like is thought to be a contributing factor to skin roughness, there is a desire for cosmetics that can alleviate this inflammation and improve skin roughness. Furthermore, superoxide is said to be involved in the production of lipid peroxide and the acceleration of aging, and an effect to eliminate it on the skin is also desired. Furthermore, it is desired to have an appropriate antibacterial effect for the purpose of preserving cosmetics, preventing skin infections, and deodorants. [0003] Problems to be Solved by the Invention [0003] Therefore, the use of plant medicines such as Cassia alata, Piper litroflatum, Euphorbia pyrulifera, Coleus scutellaoides, Cryptocarya aromatica, Curcuma haineana, and Trigonella whenumgraecum. When we investigated the application of solvent extracts to cosmetics, we found that they exhibited excellent anti-inflammatory effects (foot edema test), superoxide scavenging effects, antibacterial effects, and skin conditioning effects, and were also able to be formulated into formulations. Completed the invention. [Means for Solving the Problems] The present invention utilizes Cassia alata (Cassia alata L.), which is a herbal medicine.
), Piper ret.
urofuraotaum L. ), Euphorbia pilulifera
aL. ), Coleus scutelaoides (Coleu
scutellaioides Benth. ),
Cryptocarya aromatica
aromatica Kostem), Curcuma heyneana val
．． et v. Zjip), Trygonella foenum-grae
This cosmetic is characterized by containing one or more solvent extracts selected from the following. These herbal medicines can be commercially available in Southeast Asia such as Indonesia. [0005] Examples of methods for extracting solvent extracts of crude drugs include cutting dried crude drugs into small pieces and adding a solvent for extraction. Examples of the solvent include one or more mixed solvents selected from water-soluble solvents such as water, ethanol, n-propanol, t-butanol, propylene glycol, and 1,3-butylene glycol. Extraction may be performed at room temperature or with heating. The solvent extract can be concentrated or concentrated to dryness, if necessary, to facilitate subsequent operations. Further, if necessary, polysaccharides such as starch contained in the solvent extract can be precipitated and removed by refrigeration or the like. [0006] The solvent extract of the crude drug can be blended as a dry product in an amount of 0.001 to 10% by weight, preferably 0.01 to 5.0% by weight, based on the total amount of the cosmetic composition of the present invention. 0.
If the concentration is less than 0.001% by weight, a sufficient effect cannot be obtained;
At a concentration of 0% by weight or more, no enhancement of the effect is observed and it is uneconomical. The cosmetics of the present invention include oils and fats used in cosmetics, etc., as long as they do not impair the effects of solvent extracts of crude drugs.
Raw materials such as waxes, hydrocarbons, fatty acids, alcohols, esters, and surfactants can be blended. The cosmetics of the present invention include basic cosmetics such as creams, lotions, milky lotions, and packs, makeup cosmetics such as foundations and lipsticks, hair cosmetics such as hair creams, hair lotions, shampoos, and conditioners, bath additives, A dosage form such as soap can be adopted. EXAMPLES Next, examples will be given to explain the present invention in detail, but the present invention is not limited thereto. still,
The amounts shown in Examples are parts by weight. Example-1
100g of shredded dried Cassia alata leaves
Extraction was carried out twice at 100° C. for 2 hours after adding 2 L of water to each sample. The obtained extract was filtered and freeze-dried to obtain about 22 g of a hot water extract of Cassia alata leaves. Additionally, seeds of Piper lithophulatum, leaves of Euphorbia pyrrhifera, leaves of Coleus scutellaoides, bark of Cryptocarya aromatica, rhizomes of Curcuma hyneana, and seeds of Trigonella whenumgraecum were similarly extracted. The amount of extract of each crude drug was 3 to 25 g per 100 g of dry raw material. Example 2 Dried seeds of Piper litroflatum were shredded,
After adding 1 L of ethanol to each of the 100 g, reflux extraction was performed twice at 60° C. for 2 hours. The obtained extract was filtered and concentrated to dryness to obtain about 8 g of an ethanol extract of Piper litroflatum seeds. moreover,
Leaves of Cassia alata, Euphorbia pyrrhifera leaves, Coleus scutelaoides leaves, Cryptocarya aromatica bark, Curcuma haineana rhizomes, and Trigonella hoenumgraecum seeds were similarly extracted. The amount of extract of each crude drug is 5 to 10 g per 100 g of dry raw materials.
Met. Example 3 Dried leaves of Coleus scutellaoides were shredded, and 100 g of the dried leaves were mixed with 1,3-butylene glycol (1,3-B
1 L of a mixture of G) and water (1:1) was added, and the mixture was extracted at room temperature for 2 days. After extraction, each of the extracts was filtered to obtain about 900 ml of 1,3-BG extract of Coleus scutelaoides leaves. Furthermore, leaves of Cassia alata, seeds of Piper lithophulatum, leaves of Euphorbia pyrrhifera, bark of Cryptocarya aromatica, rhizomes of Curcuma hyneana, and seeds of Trigonella whenumgraecum were similarly extracted (yield 800~ 950ml
). Example-4 Lotion formulation
Blend amount 1. ethanol
5
．． 0 copies 2. Methyl P-oxybenzoate
0.1 3
．． Polyoxyethylene (40) hydrogenated castor oil
0.1 4. fragrance

Appropriate amount 5. purified water

10.0 6. Euphorbia pyrulifera hot water extract obtained in Example 1
0.05 7. Hot water extract of Coleus scutelaoides obtained in Example 1
0.05 8.1,3-butylene glycol
8.0 9. glycerin

2.010. xanthan gum

0.0211. purified water

74.5 Manufacturing method: Components 1 to 5 and Component 6
- 11 are uniformly dissolved, mixed and filtered to obtain a product. Comparative Example-1 Conventional lotion In Example-4, the hot water extracts of Euphorbia pyrulifera and Coleus scutellaoides obtained in Example 1 were replaced with purified water, and a conventional lotion was used. . Example-5 Cream formulation
Blend amount 1. stearic acid
4.
0 copies 2. cetyl alcohol
3.0
3. stearyl alcohol
1.0 4. liquid paraffin
6.5 5. Vaseline

10.0 6. sorbitan monostearate
2.5 7. Polyoxyethylene (25
) Monostearate 3.0 8
．． 1,3-butylene glycol
5.0 9. potassium hydroxide
0.110. Hot water extract of Coleus scutelaoides obtained in Example 1
0.0511. Hot water extract of Cassia alata obtained in Example 1
0.0512. Methyl P-oxybenzoate
0.2 13. purified water

64.714. fragrance

Proper amount production method: Oil phase components 1 to 7 and water phase components 8 to 13 at 70 to 75°C, respectively.
After heating and dissolving, add water phase components 8 to 13 to oil phase components 1 to 7.
Add and emulsify, add component 14 while cooling and mix,
The product is cooled to 30°C. Example-6 Emulsion formulation
Blend amount 1. stearic acid
2.
0 copies 2. stearyl alcohol
2.0 3.
liquid paraffin
8.0 4. glycerin monostearate
2.3 5. sorbitan monooleate
2.5 6. Polyoxyethylene (10) sorbitan monooleate 0.8 7. glycerin

6.0 8. Hot water extract of Piper litrofuratum obtained in Example 1
0.01 9. Methyl P-oxybenzoate
0.210. purified water

77.411. fragrance

Appropriate amount Manufacturing method: Prepare a product in the same manner as in Example-5. Comparative Example 2 Conventional Emulsion In Example 6, the hot water extract of Piper litroflatum obtained in Example 1 was replaced with purified water to obtain a conventional emulsion. Example-7 Pack formulation
Blend amount 1. polyvinyl alcohol
12.0 copies 2
．． Ethyl alcohol
5.0 3.1,
3-butylene glycol
8.0 4. Methyl P-oxybenzoate
0.2 5. Polyoxyethylene (4
0) Hydrogenated castor oil 0.
5 6. Ethanol extract of Coleus scutelaoides obtained in Example 2 0.05 7. Ethanol extract of Cryptokarya aromatica obtained in Example 2 0.05 8. citric acid

0.1 9. sodium citrate

0.310. fragrance

Appropriate amount11. purified water

73.8 Manufacturing method: Dissolve each component uniformly to form a product. Example-8 Foundation formulation
Blend amount 1. 1,3-BG extract of Curcuma haineana obtained in Example 3
0.25 parts 2. Example 3
1,3-BG of Trigonella whenumgraecum obtained in
Extract 0.25 3. stearic acid

2.4 4. Polyoxyethylene (20) Sorbitan Monostearate 1.0 5. Polyoxyethylene (20) cetyl ether
2.0 6. cetyl alcohol

1.0 7. liquid lanolin

2.0 8. liquid paraffin

3.0 9. Isopropyl myristate
6.510.
Butyl P-oxybenzoate
0.111. purified water

58.212. Carboxymethyl cellulose sodium
0.113. bentonite

0.514. Propylene glycol
4.0
15. triethanolamine
1.116. P-
Methyl oxybenzoate
0.217. titanium oxide

8.018. talc

4.019. colored pigments

5.020. fragrance

Proper amount manufacturing method:
Components 1, 2 and 16 are heated to 70° C. to cause component 12 to swell well. Component 11 in which component 13 is dispersed is added and dissolved, and then components 14 and 15 are dissolved to form an aqueous phase. Components 3 to 10 are dissolved by heating and kept at 80°C to form an oil phase. Ingredients 17-1 mixed well with the aqueous phase and crushed through a crusher
Add 9 and stir with a homomixer and keep at 75°C. The oil phase is added to this aqueous phase while stirring, cooled, and component 20 is added at 45°C, and after cooling with stirring, a product is obtained. Example-9 Hair cream formulation
Blend amount 1. stearic acid
2.
0 copies 2. stearyl alcohol
2.0 3.
liquid paraffin
8.0 4. glycerin monostearate
2.3 5. sorbitan monooleate
2.5 6. Polyoxyethylene (10) sorbitan monooleate 0.8 7. 1,3-BG extract of Euphorbia pyrulifera obtained in Example 3 0.2 8. glycerin

6.0 9. Methyl P-oxybenzoate
0.110. purified water

76.111. fragrance

Proper amount production method: Dissolve oil phase components 1 to 6 and water phase components 7 to 10 at 70 to 75°C,
Water phase components 7 to 10 are added to oil phase components 1 to 6 and emulsified, and during cooling, component 11 is added and mixed, and the product is cooled to 30°C. Example-10 Bath additive formulation
Blend amount 1. sodium sulfate
43.0
Part 2. sodium hydrogen carbonate
50.0 3.
1,3-BG extract of Coleus scutelaoides obtained in Example 3 5.0 4. Yellow No. 202 (1
)
Appropriate amount 5. fragrance

Proper amount manufacturing method: Mix each component well to make the product. Effects of the Invention: The leaves of Cassia alata, the seeds of Piper litroflatum, the leaves of Euphorbia pyrrhifera, the leaves of Coleus scutellaoides, the bark of Cryptocarya aromatica, the rhizomes of Curcuma hyneana, the rhizomes of Trigonella. The solvent extract of Hoenum Graecum seeds has excellent anti-inflammatory, superoxide scavenging, and antibacterial effects, and cosmetics containing solvent extracts of these herbal medicines have excellent It showed skin conditioning effect. Next, an experimental example will be given to explain the effects of the present invention in detail. Experimental Example 1 Anti-inflammatory test The anti-inflammatory effect of each crude drug extract was examined using the rat carrageenan paw edema method. That is, a male Wister weighing around 150g.
Using rats, each crude drug extract of Examples 1 and 2 was subcutaneously administered to the back of the neck (500 mg/Kg body weight as dry residue). One hour later, 0.1 ml of 1.0% carrageenan was subcutaneously administered to the sole of the right hind paw, and 3 hours after carrageenin administration, the paw volume of the right hind paw was measured. Physiological saline was used as a control. The measurement results are shown in Table 1. As is clear from Table 1, Examples 1 and 2
The extracts of each herbal medicine showed good anti-inflammatory effects. Also,
No abnormalities such as weight loss were observed. Furthermore, when the extract obtained in Example 3 was tested in the same manner, it showed a strong anti-inflammatory effect comparable to that of Examples 1 and 2. [Table 1] Table 1 Carrageenin paw edema test results
────────────────────
───────
sample
Suppression rate

(%)
────────────────────────
─── Hot water extract of Example 1
Cassia alata leaves
25 Piper Litroflatum Seeds 29
Euphorbia pyrrhifera leaves
33 Coleus scutelaoides leaves 77
Cryptokarya aromatica bark 6
0 Rhizome of Curcuma haineana
57 Trigonella hoenumgraecum seeds 32
Ethanol extract of Example 2
Cassia alata leaves 24
Piper lithophulatum seeds
25 Euphorbia pyrrhifera leaves 32
Coleus scutelaoides leaves 75
Cryptokarya aromatica bark 51 Curcuma haineana rhizome 51
Trigonella whenumgraecum seeds
6.8 ──────────────
──────────────
Experimental Example 2 Superoxide scavenging test The superoxide scavenging activity was measured using the nitrous acid method of Oyanagi et al. i.e. 0.1mM xanthine and 6.3
×10-2U/ml xanthine oxidase (XOD)
Superoxide was generated, nitrous acid produced by the reaction of the superoxide and hydroxylamine was colored with a coloring agent, and superoxide was quantified by absorbance at 550 nm. The superoxide elimination rate (%) was determined as the rate of decrease in absorbance when the test substance or SOD was added to the reaction system. Table 2 shows the results. Note that if the test substance had an inhibitory effect on XOD, it would be measured as an apparent superoxide scavenging activity, so the inhibitory activity against XOD was also measured at the same time. In other words, the uric acid produced by the reaction between xanthine and XOD was quantified by absorbance at 290 nm, and the amount of uric acid was compared with and without the addition of the test substance, and it was clear that the test substance had no inhibitory effect on XOD. became. The results are clear from Table 3. Among the hot water extracts of each crude drug in Example 1, Euphorbia pyrulifera leaves, Coleus scutellaoides leaves, and Cryptokarya aromatica bark had good superoxide scavenging properties. It has an effect. Also Euphorbia pyrrhifera leaves, Coleus scutellaoides leaves, Cryptokarya
The extracts of Example 2 and Example 3 of Aromatica bark were also tested in the same manner, and showed the same level of activity as Example 1. [Table 2] Table-2 Superoxide scavenging activity of crude drug extracts ────────────────────
────────────── Sample
superoxide

Erasure rate (%) ────
──────────────────────────
─── Hot water extract of Example 1
Euphorbia pyrrhifera leaves 36
Coleus scutelaoides leaves
22 Cryptokarya aromatica bark 24 ────────────
────────────────────
Experimental Example 3 Antibacterial activity test The minimum inhibitory concentration (MIC) was measured by the agar plate dilution method. That is, Mueller-Hinto in which each crude drug extract was dissolved at a concentration of 12.5 to 400 μg/ml.
Spread a loopful of each bacterial solution onto n(MH) agar medium, and
After culturing at 7°C for 20 hours, the presence or absence of growth was determined. The bacterial solution was prepared using MH broth for facultative anaerobic bacteria, which was grown for 20 hours at 37°C, and then diluted to 106 cells/ml using phosphate buffer. The results are shown in Table 3. As a result, among the hot water extracts of each crude drug in Example 1, antibacterial activity was detected in the leaves of Euphorbia pyrulifera, leaves of Coleus scutellaoides, and bark of Cryptocarya aromatica, and in particular, antibacterial activity was detected in the bark of Euphorbia pyrulifera, Coleus scutellaoides, and Cryptocarya aromatica. It showed high activity against one type of Staphylococcus aureus. In addition, the extracts of Example 2 and Example 3 of Euphorbia pyrrhifera leaves, Coleus scutellaoides leaves, and Cryptokarya aromatica bark were similarly tested.
It showed antibacterial activity comparable to that of Example 1. [Table 3] Table 3 Antibacterial activity test results (minimum inhibitory concentration %)────────────────────
────────── Sample
Ec Sa P
a ────────────────────────
─────── Example 1
hot water extract of
Euphorbia pyrrhifera leaves 0.8
0.04 0.8 Coleus scutelaoides leaves >0.8
0.04 >0.8 Cryptokarya aromatica bark >0.8
0.02 >0.8 ────────
──────────────────────
Test bacteria: Ec; Escherichia coli (Es
cherichia coli K12)
Sa; Staphylococcus aureus
occus aureus FDA209P)
Pa; Pseudomonas aeruginosa
aeruginosa ATCC9027) [0029] Skin conditioning effect Using the lotion of Example-4, the emulsion of Example-6, the conventional lotion of Comparative Example-1, and the conventional emulsion of Comparative Example-2,
A one-month trial was conducted on 15 women (20 to 35 years old) suffering from rough skin. After use, the improvement effect on rough skin was determined. The results are shown in Table 2. As a result, cosmetics characterized by containing solvent extracts of Piper lithoflatum seeds, Euphorbia pyrulifera leaves, and Coleus scutellaoides leaves exhibited excellent skin conditioning effects. [Table 4] Table 4 Skin conditioning effect ─────
──────────────────────────
──
Number of people
Judgment ────────
──────────────────
Example-4 Comparative example-1 Example-6 Comparative example-2
lotion lotion lotion lotion
──────────────────────────
──────── Much improved
10 3 10
4 Improved
3 4
2 3 Not much improvement 2
5 3
4 No improvement 0
3 0
4 ────────────
──────────────────────
Cream of Example-5, pack of Example-7, foundation of Example-8, and Example-
A similar use test was conducted for the bath additive No. 10, and it showed excellent skin conditioning effects. [0032] The hair cream of Example 9 was also tested in the same manner on women suffering from rough hair, and showed excellent improvement effects. As shown above, the herbal medicines of the present invention, such as Cassia alata, Piper litroflatum, Euphorbia pyrulifera, Coleus scutellaoides, Cryptocarya aromatica, Curcuma hyneana, and Trigonella whenumgraecum, are subjected to solvent extraction. Cosmetics that have excellent anti-inflammatory effects, superoxide scavenging effects, and antibacterial effects, and that contain one or more of these solvent extracts are excellent skin conditioning agents. It has been shown to be effective and improve the roughness of hair.

Claims (1)

[Claims] [Claim 1] One or more species selected from the herbal medicines Cassia alata, Piper litroflatum, Euphorbia pyrulifera, Coleus scutellaoides, Cryptokarya aromatica, Curcuma haineana, and Trigonella whenumgraecum. A cosmetic containing a solvent extract.