JPH04356416A - Skin cosmetic - Google Patents

Abstract

PURPOSE:To obtain a skin cosmetic, widely applicable to prevention, improvement, etc., in blackening of skin due to suntan, liver-spot and ephelis because of excellent beautifying and whitening effects and usable without anxiety due to its stability and safety. CONSTITUTION:A skin cosmetic is obtained by blending one or more extract of galenical medicines selected from Erythrinae Cortex, Muscunae Caulis Fritillariae Tuber and Polygonati Rhizoma derived from plants of the family Leguminosae or Liliaceae as essential ingredients in a skin cosmetic such as toilet water, a milky lotion, a cream, a pack, an ointment, a dispersion or a detergent in various formulation forms. The above-mentioned extracts of the herb medicines are blended at preferably about 0.0001-10.0wt.%, especially 0.01-5.0wt.% concentration expressed in terms of dried solid content. This skin cosmetic has the above-mentioned effects. A cosmetic containing the extracts of the Erythrinae Cortex and the Mucunae Caulis is capable of exhibiting excellent effects on prevention of aging and roughening of the skin.

Description

Description: [0001] The present invention relates to a skin cosmetic with excellent whitening effects, which contains an extract of a herbal medicine derived from a specific leguminous or liliaceous plant. [Prior art and problems to be solved by the invention] Conventionally,
Among skin cosmetics, whitening cosmetics are known as those for obtaining beauty effects such as preventing dark skin, age spots, and freckles. This whitening cosmetic mainly contains ascorbic acid, glutathione, colloidal sulfur, etc., and has the above-mentioned beauty effects. [0003] However, since ascorbic acid is easily oxidized, not only is it difficult to expect a certain effect to be achieved, but there are also problems in that the cosmetic itself may change color. Furthermore, glutathione and colloidal sulfur have drawbacks such as a peculiar odor and precipitation depending on the dosage form. [0004] Recently, attempts have been made to obtain a whitening effect by incorporating natural products such as crude drugs into cosmetics (Japanese Patent Application Laid-open Nos. 88333-1988, 2344-1980, 2003-1983, No. 57-163307, JP-A No. 60-104005, Fragrance Journal Extra Edition No. 6 (1986
) P164-166 etc.). Although these herbal medicines are expected to be useful because of their high safety, their whitening effects are still insufficient. [Means for Solving the Problems] In view of the above-mentioned circumstances, the present inventors have conducted extensive research into the whitening effects of extracts of herbal medicines, and as a result, have developed extracts of herbal medicines derived from specific Fabaceae and Liliaceae plants. The present invention was completed based on the discovery that these have a high tyrosinase activity inhibiting effect, and that cosmetics containing these have excellent whitening effects, as well as excellent safety and stability. [0006] That is, the present invention provides a skin cosmetic containing one or more extracts of herbal medicines selected from sea tung bark, chicken blood wisteria, shellfish mother, and yellow essence. . [0007] Crude drug extracts (hereinafter referred to as "
There are no particular limitations on the method for preparing the crude drug extract. However, a preferred method for extracting crude drugs is, for example, a method in which extraction is performed at room temperature or under heating using various appropriate solvents. Extraction solvents used for this include water; methyl alcohol, ethyl Lower monohydric alcohols such as alcohol; liquid polyhydric alcohols such as glycerin, propylene glycol, and 1,3-butylene glycol; lower alkyl esters such as ethyl acetate; hydrocarbons such as benzene and hexane; ethers such as diethyl ether, etc. Examples are given below, and one or more of them can be used. Among these, it is preferable to use water or a water-soluble solvent, particularly one or a mixed solvent of two or more of water, ethyl alcohol, glycerin, and 1,3-butylene glycol. [0008] The extraction conditions are as follows: using a solvent in an amount of 1 to 1000 times, especially 5 to 100 times, the volume of the crude drug, at a temperature of 4°C or higher, especially 15 to 30°C, for 1 hour or more, especially 1 It is preferable to carry out the treatment for up to 3 days. [0009] The crude drug extract obtained under the above conditions may be blended into the skin cosmetics of the present invention as an extracted solution, but if necessary, it may be further processed by concentration, filtration, etc. as appropriate. They can also be used and combined. [0010] All of the above herbal medicine extracts in the present invention have a whitening effect, but in addition to this, the extracts of sea tung bark and chicken blood wisteria have an anti-aging effect on the skin and an effect on improving rough skin due to active oxygen scavenging action. have Therefore, the above-mentioned herbal medicine extracts are incorporated into skin cosmetics that are expected to have their respective effects. [0011] In the skin cosmetics of the present invention, the content of crude drug extract is 0.0001 to 10 in terms of dry solid content.
．． It is preferably about 0% by weight, especially from 0.01 to
A range of 5.0% by weight is preferred. If the content of the crude drug extract is less than 0.0001% by weight, the effect will not be sufficiently exhibited, and if the content exceeds 10% by weight, the effect will be almost constant. The skin cosmetic of the present invention contains, in addition to the herbal medicine extract as the above-mentioned essential ingredient, aqueous ingredients, powders, surfactants, oils, moisturizers, alcohol, which are commonly used in cosmetics, quasi-drugs, and pharmaceuticals. pH adjuster, preservative, thickener, pigment,
It is prepared by appropriately blending fragrances and the like as necessary. The dosage form of the skin cosmetic of the present invention is not particularly limited, and may include lotions, milky lotions, creams, packs, ointments, dispersions,
It can be made into various formulations such as cleaning agents. [0014] Furthermore, the skin cosmetic of the present invention may further contain known drugs if necessary. This drug is
For example, agents with whitening effects such as ascorbic acid, placenta extract, toki extract, mulberry bark extract, and aloe extract; anti-inflammatory agents such as glycyrrhetinic acid and its derivatives, and indomethacin; urocanic acid, benzophenone, para-aminobenzoic acid, and cinnamon. Examples include ultraviolet absorbers such as acids and their respective derivatives; antioxidants such as vitamin E, rosemary extract, and tea extract. These drugs may be used alone or in combination of two or more. EXAMPLES Next, the present invention will be explained in more detail with reference to test examples and examples, but the present invention is not limited thereto. Test Example 1 Tyrosinase activity inhibition test: Add ethyl alcohol or
80 parts by weight of a 0% ethyl alcohol aqueous solution was added, and the mixture was extracted at room temperature for 3 days with occasional stirring, and filtered to obtain extracts of each crude drug. Using each of these crude drug extracts as samples, the inhibition rate of tyrosinase activity was measured by the following measurement method. The results are shown in Table 1. [Measurement method] Each sample 0.1~
Add 10 mg of enzyme solution [Sigma, 28,000 units of tyrosinase to 0.2 ml of 0.1 M phosphate buffer (p
H6.8) dissolved in 20 ml], add 0.1 ml, and then add 0.1 M phosphate buffer (pH 6.8) to 4 m
This was incubated at 25° C. for 10 minutes. To this, 198.0 mg of a substrate solution [L-DOPA (Tokyo Kasei), which had been kept at 25°C in advance, was added to 0.0 mg.
1.0 ml dissolved in 100 ml of 1M phosphate buffer (pH 6.8) was added and allowed to react for 10 minutes. The optical density (ODS) at 475 nm was then measured. Furthermore, the absorbance (ODHE) of the same reaction using the enzyme inactivated by heat and the absorbance (ODHE) when no sample was added (
ODB) was measured, and the inhibition rate of tyrosinase activity was calculated from the following formula.
ODB-ODS Tyrosinase activity inhibition rate (%) = ────────×100

ODB-ODHE 0018] Table 1 ──────────────
──────────────────────

Amount of sample solution added Herbal drug name Extraction solvent ──────────
───
0.2m
l 0.1ml ────────────
──────────────────────
sea paulownia bark ethyl alcohol
51.4(%) 20.2(%)
chicken blood wisteria ethyl alcohol
56.1 51.5
Shellfish mother 50% ethyl alcohol
62.5 41.6
Cole water solution
yellow spirit ethyl alcohol
56.1 43.2
〃 50% ethyl alcohol
55.5 45.4
Cole water solution
──────────────────────────
───────── [0019] As is clear from the results in Table 1, the paulownia skin, chicken blood wisteria, shellfish mother,
Each extract of Yellow Essence suppressed tyrosinase and reduced the production of dopachrome, and had a high whitening effect. [0020] Test Example 2 Active oxygen removal effect test: 20 parts by weight of chopped dried herbal medicines shown in Table 2 were mixed with ethyl alcohol, 50% (V/V).
80 parts by weight of an aqueous ethyl alcohol solution or water was added, and extraction was performed at room temperature for 3 days with occasional stirring, followed by filtration to obtain extracts of each herbal medicine. Using each of these herbal medicine extracts as samples, the active oxygen removal rate was measured by the following measurement method. The results are shown in Table 2. [Measurement method] Add 0.1 ml of substrate solution [3.0 mM xanthine (dissolved in 0.05 M sodium carbonate buffer)] to 2.4 ml of 0.05 M sodium carbonate buffer (pH 10.2), 3. 0mM EDTA
Mix 0.1 ml of 0.1 ml, 0.15% (W/V) bovine serum albumin, 0.1 ml of 0.75 mM nitroblue-tetrazolium, and 0.1 ml of each sample.
After leaving the mixture for 10 minutes at °C, 0.1 ml of an enzyme solution [xanthine oxidase solution (diluted at about 0.04 units/ml with purified water)] is added to start the reaction. After 20 min incubation at 25°C, 6mM CuCl2
Add 0.1 ml to stop the reaction. Then 560n
Measure the absorbance (A) at m. For the control, absorbance was obtained by adding purified water instead of the sample (B), and for each sample blank, 0.1 ml of 6mM CuCl2 was added to stop the reaction, and then 0.1 ml of xanthine oxidase was added (C). was measured, and the active oxygen removal rate was calculated from the following formula.
B-(A-C) Active oxygen removal rate (%) = ─────
─── ×100
B 0022
Table 2 ────────────
──────────────────────

Sample solution
Liquid Herbal Medicine Name Extraction Solvent ────────────────

5% solution 2% solution 1%
Solution ──────────────────────
──────────── Umi paulownia skin 50
% Ethylal 61.5 38.5
26.9 Cole aqueous solution Chicken blood Wisteria 50% ethyl alcohol
93.0 66.9 43.
2 Cole aqueous solution
chicken blood wisteria water
67.1 36.2 19.
4 ──────────────────────
─────────── [0023] As is clear from the results in Table 2, the extracts of sea tung bark and chicken blood wisteria used in the present invention remove active oxygen and have high SOD-like antioxidant properties. It had activity. [0024] Example 1 Lotion: <Composition>
(Weight %) (1) Glycerin

5.0 (2) 1,3-butylene glycol
4.0 (3)
oleyl alcohol
0.1 (4) Polyoxyethylene sorbitan monolauric acid ester (20E.O.)
1.5 (5) Polyoxyethylene lauryl ether (20E.O.)

0.5 (6) Ethyl alcohol
10.0
(7) Sorbitol
1.0
(8) Sea tung bark ethyl alcohol extract*1
0.5 (9) Vitamin E
0.1 (10) Oxybenzone
0.2 (11) Preservative

Appropriate amount (12) Fragrance

Appropriate amount (13) Purified water

Remaining amount ──────────────
──────────────────
total
100.0*1: Approx.
Containing 8% 0025〈Manufacturing method〉A. (3) to (6) and (9) to (12) are mixed and dissolved. B. Mix and dissolve (1), (2), (7), (8) and (13). C. Mix A and B until uniform. Example 2 Cream: <Composition>
(Weight %) (
1) Beeswax
6.0 (
2) Setanol
5.0 (3
) reduced lanolin
8.0 (4)
Squalane
37.0 (5) Glycerin monostearate
4.0 (6) Lipophilic glyceryl monostearate 2.0 (7
) Polyoxyethylene sorbitan mono
Lauric acid ester (20E.O.)
2.0 (8) Shellfish water extract *
2
5.0 (9) Preservatives

Appropriate amount (10) Fragrance

Appropriate amount (11) 1,3-butylene glycol 5
．． 0 (12) Purified water
Residue
Amount ──────────────────────
──────── Total

100.0*1: Contains about 8% dry solid content of shellfish mother extract (obtained in the same manner as Test Example 1) [0027] <Production method> A. Mixing (1) to (7) and (9) to (10),
Heat and keep at 70°C. B. Mix (8), (11) and (12), heat and keep at 70°C. C. Add A to B, emulsify uniformly, and cool to 30°C. [0028] Example 3 Pack: <Composition>
(Weight %) (1) Polyvinyl alcohol
15.0 (
2) Sodium carboxymethylcellulose
5.0 (3) Propylene glycol 3
．． 0 (4) Huangsei 1,3-butylene glycol extract*3 2.5 (5) Ethyl alcohol
10.0 (6) Urocanic acid

0.1 (7) Preservative

Appropriate amount (8) Flavoring

Appropriate amount (9) Purified water

Remaining amount ────────────
──────────────────
total
100.0*3
: Contains about 1.0% of dry solid content of Yellow Essence Extract (obtained in the same manner as Test Example 1) [0029]
Manufacturing method〉A. (1) to (4), (6) and (9) are mixed and heated to 70°C to dissolve while stirring. B. Mix (5), (7) and (8). C. Add B to A, mix, and then cool. Example 4 Emulsion: <Composition>
(Weight %) (1) Squalane

5.0 (2) Vaseline

2.0 (3) Beeswax

0.5 (4) Sorbitan sesquioleate 0.8 (5) Polyoxyethylene oleyl ether (
20E. O. )
1.2 (6) 1,3
-butylene glycol
5.0 (7) Chicken blood wisteria ether extract*
4
(as dry solids)
0.1 (
8) Ethyl alcohol
5.0 (9)
Preservative
Appropriate amount (10)
fragrance
Appropriate amount (11)
Carboxyvinyl polymer (
1.0% aqueous solution)
20.0 (12) Potassium hydroxide

0.1 (13) Purified water

Remaining amount ────────────────
──────────────
total
100.0 *4: Extracted and dried in the same manner as Test Example 1. <Production method> A. Heating and mixing (6) to (8) and (13), 7
Keep at 0℃. B. (1) to (5), (9) and (10) are heated and mixed and kept at 70°C. C. Add A to B and mix, then add (11) and mix uniformly, then add (12) and emulsify uniformly.
Cool to 0°C. Test Example 3 Usage Effect Test: The skin whitening effect of the skin cosmetic of the present invention was tested by use test. The usage test was conducted with a panel of 20 women aged 30 to 40, who applied an appropriate amount of the test cosmetic to their faces twice a day, once in the morning and once in the evening, after washing their faces for two weeks. The cream of Example 2 and the milky lotion of Example 4 were used as test cosmetics, and as a control, the cream of Example 2 except for the shellfish mother extract (8) and corrected with purified water was used. The results are shown in Table 3. Note that the evaluation was performed based on the following criteria. [Whitening effect] Effective: Spots and freckles are almost invisible. Slightly effective: Spots and freckles are less noticeable. Invalid: No change. [0034]
Table 3 ──────
────────────────────────

Whitening effect sample
──────────────

Effective Somewhat effective Ineffective ────────────────────
──────────── Cream of Example 2 11 6
3 Milk of Example 4
liquid 13 3
4 contrast
Item 0
4 16 ────────
────────────────────── [
As is clear from the results in Table 3, Example 2
By using the cream of Example 4 and the emulsion of Example 4, spots and freckles became less noticeable and an excellent whitening effect was obtained. Furthermore, almost the same usage tests were conducted for the lotion of Example 1 and the pack of Example 3, and as a result, similar effects were obtained. Example 5 Except that 0.5% of a 50% aqueous ethyl alcohol extract of sea tung bark (containing approximately 7% dry solid content of sea tung bark extract) was added as component (8). A lotion was obtained in the same manner as in Example 1. Example 6 Same as Example 2 except that 3.0% of sea tung skin water extract (containing sea tung skin extract in dry solid content of about 6%) was added as component (8). Then I got the cream. Example 7 The same procedure was carried out except that 3.0% of chicken blood wisteria 1,3-butylene glycol extract (containing 6% chicken blood wisteria extract as dry solid content) was added as component (4). A pack was obtained in the same manner as in Example 3. Example 8 A milky lotion was obtained in the same manner as in Example 4, except that 0.1% (as dry solid content) of chicken blood wisteria ether extract was blended as component (7). Test Example 4: Use and Effect Test: The skin cosmetic composition of the present invention was tested for its anti-aging effect on skin and its effect on improving rough skin by use test. The usage test was conducted using a panel of 20 women aged 30 to 55 years by applying the test cosmetic to their faces twice a day, once in the morning and once at night, after washing their faces for 12 weeks. The test cosmetics used were the cream of Example 6, the milky lotion of Example 8, and the cream of Example 6, except that component (8) sea tung skin aqueous extract was removed and the control products were corrected with purified water. The results are shown in Table 4. Note that the evaluation was performed based on the following criteria. Effective in preventing skin aging: Skin firmness and luster were improved. Slightly effective: Skin firmness and luster were slightly improved. Invalid: No change from before use. Effective for improving rough skin: The dryness and roughness of the skin has been improved. Slightly effective: The dryness and roughness of the skin was slightly improved. Invalid: No change from before use. [0042] No.
4 Table ──────────────────
──────────────────
Skin aging prevention effect Skin roughness improvement effect trial
Fee ────────────
────────────
Effective Somewhat effective Ineffective
Effective Somewhat effective Ineffective ──────
──────────────────────────
─── Cream of Example 6 18
2 0 13 6
1 Emulsion of Example 8 14
4 2 15
50 control
Product 0 3 17
0 4 16 ───
──────────────────────────
────── As is clear from the results in Table 4, the cream of Example 6 and the emulsion of Example 8 were effective in preventing skin aging and against rough skin. Effects of the Invention As detailed above, the skin cosmetic of the present invention has an excellent whitening effect, so it can be widely applied to prevent and improve skin darkening, age spots, and freckles caused by sunburn. Can be done. In particular, the skin cosmetic of the present invention containing tung bark and chicken blood wisteria extract exhibits excellent effects in preventing skin aging and rough skin in addition to the above-mentioned effects. Furthermore, the skin cosmetics of the present invention are stable and safe, so they can be used with confidence. that's all

Claims (1)

[Claims] 1. A skin cosmetic containing one or more extracts of herbal medicines selected from sea tung bark, chicken blood wisteria, shellfish mother, and yellow essence.