JP3084104B2 - Cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a novel cosmetic. More specifically, the present invention relates to a cosmetic having a whitening action and an anti-inflammatory action, which contains a water-soluble extract of hydrangea of the family Yuki no Hami as an active ingredient.

[0002]

2. Description of the Related Art The mechanism of the occurrence of skin spots, freckles, etc. is unknown, but in general, melanin pigments are formed due to hormonal abnormalities and irritation of ultraviolet rays from sunlight. It is thought to be abnormal deposition. For the treatment of such spots and freckles, a method of administering a large amount of a substance that inhibits the activity of tylinase present in the skin to suppress melanin production, for example, vitamin C, glutathione ointment, cream , Lotions and the like, and a method of applying the composition locally.
In the United States and Europe, hydroquinone preparations are used as pharmaceuticals.

[0003] On the other hand, various skin irritation, for example, the skin is irritated by the action of ultraviolet rays, and those that suppress these inflammations are anti-inflammatory agents, and as ingredients for cosmetics, there are aloe, loofah and the like. Plant extract, glycyrrhizin,
Zinc white etc. are used.

[0004] Further, when the moisture content of the stratum corneum of the skin is reduced, the skin becomes rough and the like. Glycerin, 1,3-butylene glycol, propylene glycol, hyaluronic acid and the like are used as humectants in order to give the stratum corneum an appropriate water content.

[0005]

[Problems to be Solved by the Invention] Vitamin C is heat,
Poor stability over time with light, especially in systems containing water, causing discoloration and odor. On the other hand, the use of hydroquinones is restricted because of problems in safety such as skin irritation and allergicity. In addition, there is a problem in terms of stability because the air is easily oxidized. Thiol-based compounds such as glutathione and cysteine have a strong off-flavor, are easily oxidized, and have a slow effect. Also, 2-mercaptoethyl amine salt, N-(2-mercaptoethyl) dimethylamine salt and the like, have been known to bleaching the skin of black guinea pig, since white spots are likely to occur after the bleaching, generally used Not.

[0006] On the other hand, as described above, there are various components having a whitening effect and an anti-inflammatory effect, but in order to produce a cosmetic having these effects, only a plurality of these components must be added. In many cases, attention must be paid to product stability.

In view of such circumstances, the present inventors have conducted intensive studies, and as a result, it has been found that a cosmetic containing a water-soluble extract of hydrangea of the family belonging to the family of Ishigaki as an active ingredient has good whitening and anti-inflammatory effects. It has been found that the present invention has been completed.

[0008]

SUMMARY OF THE INVENTION The present invention is a cosmetic containing a water-soluble extract of Hydrangea belonging to the family of Yuki- no-mami as an active ingredient.

[0009] Plants belonging to the family of Yuki-no-kami are other
Saxifrage, cornflower genus and the like. So
And whitening effect that blended snowy citrus and cornflower
As a result, cosmetics for the purpose of anti-inflammatory effects have been disclosed.
Kaihei 2-49712, JP-A-60-94905, well-known and commonly used technology
Shu, extra edition of fragrance journal 2). Where
The genus Saxifraga longens the creeping branch from the root,
Put on the ground and make new shoots at the tip. The leaves are rooted and long handle
There is. The stem is 20cm to 50cm in height, flowers are late spring to summer, petals are
The bottom two are noticeable in 5 pieces. Cornflower
Lumasou is about 1m in height, and the leaves have long stems and large diameters.
About 50cm. The flowers are in early summer and have no petals. The shape of the stem is one with the carp streamer
It resembles an arrow wheel set up.

[0010] In contrast, the Yukinoshi used in the present invention.
Hydrangea macr
ophylla Seringe var. otaksa Makino, the first flower
In summer, all are decorative flower pieces, petals, stamens, pistils
Degenerate and do not bear fruit. (Principal Color Makino Plant Encyclopedia, Makino Tomitaro
Author, Kitatakakan,) Thus, hydrangea is Yukinoshita, ya
It is a plant that has a different genus and a completely different shape from
is there.

The water-soluble solvent used in the present invention is water or a water-soluble solvent, such as water, alcohols (methanol, ethanol, 1,3-butylene glycol, propylene glycol, etc.). ), Acetone and the like.
Further, the extraction of the plant of the present invention is performed by using one of these water-soluble solvents.
It may be extracted using a species or a mixed solvent of two or more species. Further, it may be one extracted by heating or one extracted at normal temperature. If necessary,
It can be concentrated or diluted and used as a cosmetic raw material.

[0012] In the cosmetics of the present invention, the Saxifragaceae horse mackerel
Oils and fats, waxes, hydrocarbons, fatty acids, alcohols, esters, metal soaps, surfactants, etc. can be blended as raw materials within the range that does not impair the effect of the water-soluble extract of rhinoceros. it can.

[0013] Cosmetics produced using these base materials as raw materials include, for example, lotions, creams, emulsions, shampoos, foundations, lip creams, lipsticks and the like.

[0014] A of snow family to be used in cosmetic composition of the present invention
The amount of the water-soluble extract of sugar beet used is 0.01 to 1 based on the total amount of the cosmetic as a solid content obtained by distilling off the solvent.
It is appropriate to add 0% by weight, preferably 0.1 to 5.0% by weight. If the content is less than 0.01% by weight, a sufficient effect cannot be expected, and if the content exceeds 10% by weight, the effect is not enhanced and it is uneconomical.

The method of addition may be added in advance or may be added during the production, and may be appropriately selected in consideration of workability.

[0016]

EXAMPLES The present invention will be described in more detail with reference to the following Examples, which should not be construed as limiting the invention thereto. In addition, the part shown in an Example shows a weight part, and% shows weight%.

Example 1 100 g of dried hydrangea was ground, extracted with 1000 ml of a water-ethanol mixture (1: 1) with heating for 5 hours, and concentrated to obtain 30 g of the extract (50% solids were removed). Including).

Example 2 Lotion (1) Hot water extract of hydrangea (99% as a solid) 5.0 parts (2) Glycerin 2.0 (3) Ethyl alcohol 7.0 (4) Paraoxybenzoate Methyl acrylate 0.05 (5) Polyoxyethylene (20) Lauryl ether 0.5 (6) Citric acid 0.01 (7) Sodium citrate 0.1 (8) Fragrance 0.1 (9) Purified water Component (2) to (4) and (8) are mixed and dissolved to make the total amount 100. Separately, components (1), (5) to (7), and (9) are mixed and dissolved. Then, both are mixed and filtered through a Tetron cloth (300 mesh) to obtain a product.

Example-3 Cream (1) Hot water extract of hydrangea (99% as solid) 2.0 parts (2) Squalane 5.5 (3) Olive oil 3.0 (4) Stearic acid 2.0 (5) Beeswax 2.0 (6) Octyldodecyl myristate 3.5 (7) Polyoxyethylene (20) cetyl ether 3.0 (8) Behenyl alcohol 1.5 (9) Glycerin monostearate 2.5 (10) ) 1,3-butylene glycol 8.5 (11) Methyl paraoxybenzoate 0.2 (12) Ethyl paraoxybenzoate 0.05 (13) Fragrance 0.1 (14) Ingredient 100 with purified water (2) to (9) are dissolved by heating and mixed, and kept at 70 ° C. to obtain an oil phase. The components (1) and (10) to (12) are dissolved in the component (14) by heating and mixed, and the mixture is kept at 75 ° C. to form an aqueous phase. The oil phase is added to the water phase to emulsify, and the mixture is cooled to 30 ° C. while adding and stirring the component (13) to obtain a product.

Example-4 Emulsion (1) Ethanol extract of hydrangea (99% as solid content) 1.0 part (2) Squalane 5.0 (3) Olive oil 5.0 (4) Jojoba oil 5.0 ( 5) Cetyl alcohol 1.5 (6) Glycerin monostearate 2.0 (7) Polyoxyethylene (20) Cetyl ether 3.0 (8) Polyoxyethylene (20) Sorbitan monooleate 2.0 (9) Dipropylene glycol 1.0 (10) Glycerin 2.0 (11) Fragrance 0.1 (12) Methyl parahydroxybenzoate 0.2 (13) Make the total amount 100 with purified water Components (2) to (8) Is heated and dissolved and mixed, and kept at 70 ° C. to obtain an oil phase. Components (1), (9), (10), (1
2) is heated and dissolved in the component (13) and mixed, and kept at 75 ° C. to obtain an aqueous phase. The aqueous phase is added to the oil phase to emulsify and disperse, and the mixture is cooled to 30 ° C. while adding and stirring the component (11) to obtain a product.

Example-5 Pack (1) Propylene glycol extract of hydrangea (20% as a solid) 3.0 parts (2) Polyvinyl alcohol 11.5 (3) 1,3-butylene glycol 2.5 (4) ) Polyoxyethylene (40) Hardened castor oil 1.0 (5) Ethyl alcohol 7.0 (6) Methyl paraoxybenzoate 0.2 (7) Fragrance 0.05 (8) Make the total amount 100 with purified water Components (1) to (8) are heated and dissolved at 75 ° C.
Cool until finished. Good in Examples 2 to 5
It has a great anti-inflammatory and whitening effect .

[0022]

The cosmetic containing the water-soluble extract of hydrangea of the present invention as an active ingredient has a highly stable whitening action and anti-inflammatory action, and is also preferable in terms of safety. is there. Hereinafter, effects of the present invention will be described with reference to experimental examples.

[Experimental Example] Efficacy Test Example 1 Whitening Effect To examine the inhibitory effect on tyrosinease activity, 0.0
The tyrosinase activity inhibitory power of the 5% aqueous solution before and after the heat treatment at 37 ° C. for 2 weeks was measured. As a comparative example, ascorbic acid, luffa water and hot water extract of luffa fruit conventionally used as cosmetics were similarly tested. The sample used was the extract obtained in Example 1. As a method for preparing a hot water extract of loofah (comparative example), 10 g of a dried product was extracted with hot water (95 ° C., 3 hours, 30 hours).
(0 ml), the filtrate was lyophilized in vacuo.

Measurement of Tyrosinease Inhibition Activity: 1 ml of L-tyrosine solution (0.3 mg / ml), 1 ml of Max Bain's buffer (pH 6.8) in a test tube, and 0.15% aqueous solution of the sample Add 0.9 ml and add 37
The mixture was incubated for 10 minutes in a constant temperature water bath at ° C. 0.1 ml of a tyrosinase aqueous solution (1 mg / ml) was added thereto, and the mixture was stirred well, incubated at 37 ° C. for 12 minutes, set on a spectrophotometer, and the absorbance at 475 nm was measured. On the other hand, the same absorbance measurement was performed using distilled water as a blank in place of the sample, and the tyrosinase activity inhibition rate of each sample was calculated by the following equation. In the formula, A means the absorbance when each sample is added, and B means the absorbance of a blank. Inhibition rate (%) = (1-A / B) × 100

Table 1 shows the results of these tests. As is clear from Table 1, the water-soluble extract of hydrangea obtained in Example 1 has a more remarkable inhibitory activity on tyrosinease activity than luffa water and a hot water extract of luffa. It has good heat stability and, after standing at 37 ° C. for 2 weeks, has a stronger inhibitory activity on tyrosinase activity than vitamin C. In addition, by these stability tests,
No odor or discoloration was observed in the water-soluble extract of hydrangea

[0026]

[Table 1]

Efficacy Test Example 2 Anti-Inflammatory Activity In order to examine the anti-inflammatory effect, samples were prepared at 0.01% and 0.1%.
The histamine release inhibition test was performed for each aqueous solution containing 1.0% and 1.0%. As a comparative example, a luffa water and a hot water extract of Kitachiaroe conventionally used in cosmetics were similarly tested. The water-soluble extract of hydrangea and luffa water are the same as those used in Experimental Example 1. In addition, hot water extract of Kidachi aloe (as a preparation method of Comparative Example, 10 g of a dried product was heat-extracted with 300 ml of water for 3 hours and freeze-dried in vacuum (containing 99% or more solids).

Histamine release inhibition test; male Spraqu according to the report of Hirai et al. (Japanese Journal of Pharmaceutical Sciences, 37 , 374, 1983.)
The histamine release inhibitory effect on mast cells collected from the intraperitoneal cavity of e-Dawley rats (200 to 450 g) was measured. That is, 4 ppm of the compound 48/80
The effect of inhibiting histamine release due to was determined as the release inhibition rate (%).

The results are shown in Table 2. From these results, the hot water extract of hydrangea obtained in Example 1 has a remarkable inhibitory effect on histamine release as compared with the hot water extract of luffa water and Kitachiaroe, and also has an excellent anti-inflammatory effect. I found that.

[0030]

[Table 2]

Efficacy Test Example 3 Safety Test In order to clarify the safety of the water-soluble extract of Hydrangea of the present invention, a primary irritation test on humans was performed by an occlusion patch test. In other words, using a fin chamber (made by EPITEST), 30 healthy people
Obstruction was applied to the forearm flexion side for 48 hours, and after removal of the patch for the patch test, the determination was made using the average value of the determinations after 1 hour, 24 hours, and 48 hours. The sample used was the water-soluble extract obtained in Example 1, and the coating concentration was 10% (W / W).
An aqueous solution was used, and distilled water was used as a control. As a result, no erythema was observed in the water-soluble extract of hydrangea , while slight erythema was observed in 5 persons in the control distilled water. From these results, it was confirmed that the water-soluble extract of hydrangea had extremely low primary irritation and was highly safe for the skin. that's all

──────────────────────────────────────────────────続 き Continuation of front page (72) Muneyoshi Oka 2-130 Tomicho, Nishi-ku, Nagoya-shi, Aichi Japan Menard Cosmetics Co., Ltd. Examiner at Central Research Laboratory Naoko Tsukanaka (56) References JP-A-3-128315 JP-A-2-72111 (JP, A) JP-A-2-49714 (JP, A) JP-A-2-49713 (JP, A) JP-A-2-49712 (JP, A) JP-A-60-94905 (JP, A) JP-A-57-14700 (JP, A) "Well-known and commonly used techniques (cosmetics and similar products)" issued by the Japan Patent Office on August 21, 1984, page 26 Extra edition of Fragrance Journal 2, published by Fragrance Journal on August 1, 1980. 102-107 (58) Fields investigated (Int.Cl. ⁷ , DB name) A61K 7/48 A61K 7/00 A61K 35/78

Claims (1)

(57) [Claims] 1. A cosmetic composition comprising a water-soluble extract of a hydrangea belonging to the family of Yuki- no-kami.