JPH04279511A - Cosmetic - Google Patents

Abstract

PURPOSE:To provide a cosmetic having highly stable skin-beautifying and antiinflammatory actions and desirable stability. CONSTITUTION:Whole grass of Pyrrola japonica, Pyrrola incarnata, Pyrrola renifolica, etc., of the genus Pyrrolaceae is extracted with water and/or a water- soluble solvent [e.g. alcohol (e.g. methanol, ethanol, 1,3-butylene glycol and propylene glycol) and acetone] at ordinary temperature or under heating, and the obtained water-soluble solvent extract is used as an essential component of a cosmetic such as cosmetic, cream, milky lotion, shampoo, foundation, lip cream and lipstick in an amount of 0.01-10wt.% (preferably 0.1-5.0wt.%) (in terms of solid obtained by distilling off the solvent, based on the total cosmetic) to obtain the objective cosmetic having the above effects.

Description

[Detailed description of the invention]

0001

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a new cosmetic composition. More specifically, it is a cosmetic that is characterized by containing a water-soluble solvent extract of the whole plant of a plant belonging to the family Alocataceae as an active ingredient, which has both stable whitening and anti-inflammatory effects, and which is also preferable in terms of safety. Regarding.

0002

[Prior Art] The mechanism by which skin spots and freckles occur is still unclear, but in general, melanin pigments are formed due to hormonal abnormalities or stimulation of ultraviolet rays from sunlight, and this is caused by the formation of melanin within the skin. It is thought that it is abnormally deposited. To treat such age spots and freckles, substances that inhibit tyrosinase activity in the skin and suppress melanin production, such as large doses of vitamin C, or glutathione in ointments or creams, can be used. For example, it is applied locally in the form of a lotion or the like. Additionally, hydroquinone preparations are used as pharmaceuticals in Europe and America.

[0003] In addition, various skin irritations, such as the action of ultraviolet rays, cause skin inflammation, and anti-inflammatory agents suppress these inflammations.
Plant extracts such as aloe and loofah, glycyrrhizin, zinc oxide, etc. are used.

0004

[Problem to be solved by the invention] Vitamin C
It has poor stability against light over time and causes discoloration and odor, especially in systems containing water. On the other hand, hydroquinone-based compounds have safety problems such as skin irritation and allergy, so their use is restricted, and furthermore, they are susceptible to air oxidation, which causes problems in terms of stability. Thiol compounds such as glutathione and cysteine have a strong off-flavor, are easily oxidized, and have slow effects. 2-Mercaptoethylamine salt, N
-(2-Mercaptoethyl)dimethylamine salt etc. are known to bleach the skin of black guinea pigs, but
It is not generally used because it tends to cause white spots after decolorization.

On the other hand, there are various ingredients that have whitening and anti-inflammatory effects as mentioned above, but in order to produce cosmetics that have both of these effects, it is necessary to add each of these ingredients. However, there are many points that must be kept in mind, such as product stability.

[0006]

[Means for Solving the Problems] In view of the above circumstances, the present inventors have conducted extensive research and have found that a cosmetic containing a water-soluble solvent extract of the whole plant of the Alocataceae family as an active ingredient has been developed. The present inventors have discovered that it has stable and good whitening and anti-inflammatory effects, and is also preferable in terms of safety, leading to the completion of the present invention.

[0007] The starting material used in the present invention may be any plant belonging to the family Alocataceae and is not particularly limited. Furthermore, the plants of the family Alocataceae used as the source of the starting material may be one type or a mixture of two or more types. Plants of the family Ichiyakudae are perennial plants that grow naturally in countries such as Japan, Korea, and China.
pyrola japonica Klenze), Pyrola incarnata
Fischer), Pyro
La renifolia Maxim. ) etc. In addition, hot water extracts of dried whole plants of these plants are known to have cardiotonic, antihypertensive, and antibacterial effects.

The water-soluble solvent used in the present invention is water or a water-soluble solvent, such as alcohols (methanol, ethanol, 1,3-butylene glycol, propylene glycol, etc.), acetone, etc. Examples include. Also,
The plant extraction of the present invention may be performed using one or a mixed solvent of two or more of these water-soluble solvents. Further, it may be extracted by heating or extracted at room temperature. If necessary, it can be concentrated or diluted and used as a cosmetic raw material.

The cosmetic of the present invention may contain oils and fats, waxes, hydrocarbons, fatty acids, alcohols, and esters within the range that does not impair the effects of the water-soluble solvent extract of the whole plant. , metal soap, surfactant, etc. can be blended as raw materials.

Cosmetics manufactured using these bases as raw materials include, for example, lotions, creams, milky lotions, shampoos, foundations, lip balms, and lipsticks.

[0011] The amount of the water-soluble solvent extract of the whole plant of the Alocataceae plant used in the cosmetic of the present invention is 0.0% as a solid content obtained by distilling off the solvent based on the entire cosmetic.
It is appropriate to add 1 to 10% by weight, preferably 0.1 to 5.0% by weight. If it is less than 0.01% by weight, no sufficient effect can be expected, and if it exceeds 10% by weight, the effect will not be enhanced and it is uneconomical.

[0012] Furthermore, the method of addition may be either added in advance or added during production, and may be selected as appropriate in consideration of workability.

The present invention will be explained in more detail with reference to Examples below, but the present invention is not limited thereto. In addition, the part shown in an Example shows a weight part, and % shows a weight%.

[0014]

[Example] Example 1 50 g of the whole plant of Ichiyakusou was shredded, heated and extracted twice with 500 ml of water for 3 hours each time, and the residue was filtered. Further, 10 g of extract (containing 99% or more solids) was obtained by concentrating by vacuum freeze-drying.

Example 2 50 g of the whole plant of Rhododendron japonica was shredded, heated and extracted twice with 500 ml of water for 3 hours each, and the residue was separated by filtration. Furthermore, 11 g of extract (containing 99% or more solids) was obtained by concentrating by vacuum freeze-drying.

Example 3 50 g of the dried whole plant of Zinnia chinensis was crushed and mixed with water-ethanol mixture (1:1).
) 500ml for 5 hours and further concentrated to obtain 13g of extract (containing 99% solids).

Example 4 [0017] 60 g of dried whole plant of Ichiyakusou was crushed, 300 ml of ethanol was added thereto, and the mixture was left at room temperature for one month. By further concentrating extract 14
g (containing more than 99% solids) was obtained.

Example 5 60g of dried russet leaves were crushed and mixed with 600ml of propylene glycol.
The extract was heated and extracted twice for 3 hours each time with 20 g of extract (containing 70% solids) by further concentration.

Example 6 Lotion (1) Hot water extract of whole plant of Ichiyakuso (99% as solid)
5.0 parts (2) Glycerin
2.0(3) Ethyl alcohol
le
7.0(4) Methyl paraoxybenzoate
0.05(5) Polyoxyoxyethylene (20) Lauryl ether
0.5 (6) citric acid

0.01(7) Sodium citrate
0.1 (8) Fragrance
0
．． 1(9) Make the total amount 100% with purified water. Mix and dissolve (2) to (4). Separate ingredient (1)
and (5) to (9) are mixed and dissolved. Then, both are mixed and filtered through Tetron cloth (300 mesh) to obtain a product.

Example 7 Lotion (1) Hot water extract of whole plant of Safflower
(99% as solid)
3.0 parts (2) Glycerin
2.0(3) Ethyl alcohol

7.0 (4) Polyoxyethylene (20) Lauryl ether
0.5(5) Methyl paraoxybenzoate
0.05(6) citric acid
0.
01(7) Sodium citrate
0.1 (8) Fragrance

0.1 (9) Mix and dissolve components (2) to (4) to make the total amount 100 with purified water. Separately, the ingredients (
Mix and dissolve 1) and (5) to (9). Then, both are mixed and filtered through Tetron cloth (300 mesh) to obtain a product.

Example 8 Cream (1) Hot water extract of the whole plant of Prunus japonicus
(99% as solid)
Part 2.0 (2) Squalane

5.5(3) Olive oil

3.0(4) Stearic acid
2.0
(5) Beeswax
2.0(6) Octyldodecyl myristate
3.5 (7) Polyoxyethylene (20) Cetyl ether
3.0(8) Behenyl alcohol
1.5(9) Glycerin monostearate
2.5(10)1
,3-butylene glycol
8.5(11) Methyl paraoxybenzoate
0.2(12) Ethyl paraoxybenzoate
0.05 (13) Fragrance

0.1 (14) Ingredients whose total amount is 100 with purified water (
2) to (9) are heated and dissolved, mixed, and kept at 70°C to form an oil phase. Components (1) and (10) to (12) are heated and dissolved in component (14), mixed, and kept at 75° C. to form an aqueous phase. Add the aqueous phase to the oil phase to emulsify, add component (13), and cool to 30°C while stirring to obtain a product.

Example 9 Emulsion (1) Ethanol extract of whole plant of Ichiyakuso
(99% as solid content)
1.0 part (2) Squalane

5.0 (3) Olive oil

5.0 (4) Jojoba oil
5
．． 0(5) Cetyl alcohol
1.5(6) Glycerin monostearate
2.0 (7) Polyoxyethylene (20) Cetyl ether
3.0 (8) Polyoxyethylene (20) Sorbitan monooleate
2.0(9) Dipropylene glycol 1.
0 (10) glycerin
2.0 (11) Fragrance
0.1(12) Methyl paraoxybenzoate
0.2 (13) Make the total amount 100% with purified water [Production method] Components (2) to (8) are dissolved and mixed by heating at 70°C.
Keep it as an oil phase. Components (1), (9), (10) and (12) are heated and dissolved in component (13), mixed, and heated to 75°C.
Maintain the aqueous phase. Add the aqueous phase to the oil phase to emulsify and disperse, add component (11), and cool to 30° C. while stirring to obtain a product.

Example 10 Pack (1) 3.0 parts of propylene glycol extract (20% as solid matter) of the whole plant of Zinnia japonica (
2) Ethyl alcohol
7.5(3) 1,3-butylene glycol
1.0(4) Polyvinyl alcohol
10.5 (5) Polyoxyethylene (40) Hydrogenated castor oil 0.5 (6)
Methyl paraoxybenzoate
0.2 (7) Fragrance

0.05 (8) Dissolve components (1) to (8) with purified water to make the total amount 100 at 75°C, and dissolve at 30°C.
Cool it until it becomes a product.

[0024]

Effects of the Invention The cosmetic composition of the present invention, which is characterized by containing at least one water-soluble solvent extract of the whole plant of Ichijakakushu, S. japonica, or G. japonica, has a highly stable whitening effect and It has an anti-inflammatory effect and is also preferable in terms of safety.

The effects of the present invention will be explained below with reference to experimental examples.

Efficacy Test Example 1 Whitening effect In order to examine the tyrosinase activity inhibition effect, the tyrosinase activity inhibition ability of the 0.15% aqueous solution of the sample was measured before and after being heat-retained at 37°C for 2 weeks. For comparison, ascorbic acid, loofah water, and a hot water extract of loofah fruit, which have been conventionally used as cosmetics, were similarly tested. In addition,
The extracts obtained in Examples 1 and 2 were used as samples. In addition, as a method for preparing a hot water extract of loofah (for comparison), 10 g of the dried product was extracted with hot water (95° C., 3 hours, 300 ml), and the filtrate was freeze-dried in vacuum.

Measurement of tyrosinase activity inhibition: In a test tube, add 1 ml of L-tyrosine solution (0.3 mg/ml), 1 ml of Max Bain's buffer (pH 6.8), and 0.15% aqueous solution of the above sample. Add 0.9ml, 3
It was incubated for 10 minutes in a constant temperature water bath at 7°C. Add 0.1 ml of tyrosinase aqueous solution (1 mg/ml) to this, stir well, and incubate at 37°C for 12 minutes.
It was set in a spectrophotometer and the absorbance at 475 nm was measured. On the other hand, similar absorbance measurements were performed using distilled water instead of the sample as a blank, and the tyrosinase activity inhibition rate of each sample was calculated using the following formula. In addition, A in the formula
B means the absorbance when each sample is added, and B means the absorbance of the blank. Formula: Inhibition rate (%) = (1-A/B) x 100

0028
] The test results are shown in Table 1. Example 1 from this table
, 2, the water-soluble solvent extract of the whole plant of Ichiyakuso or Rubus japonica obtained in 2 has more remarkable tyrosinase activity inhibiting power than loofah water and loofah hot water extract, and furthermore, this composition is thermostable. Good temperature, 37℃, 2
After being left for a week, it was found to have a stronger inhibitory effect on tyrosinase activity than vitamin C. Furthermore, in these stability tests, no odor or discoloration was observed in the water-soluble solvent extraction of the whole plant of Asus japonica or Asus japonica. Furthermore, when the water-soluble solvent extracts of the whole plants of Aspergillus japonica, Aspergillus japonica, or Aspergillus annuus obtained in Examples 3 to 5 were tested in the same manner, it was found that they exhibited similarly good tyrosinase activity inhibition ability. (Margin below)

[0029]

[Table 1]

Efficacy test example 2 Anti-inflammatory effect In order to examine the anti-inflammatory effect, samples were mixed at 0.01%, 0.1%, and 1.0%.
A histamine release inhibition test was conducted for each aqueous solution contained. For comparison, loofah water and a hot water extract of Kidachi aloe, which have been conventionally used in cosmetics, were similarly tested. Note that the extracts obtained in Examples 1 and 2 were used as samples. In addition, as a method for preparing a hot water extract (for comparison) of Kidachialoe, 10 g of the dried product was extracted with hot water (95°C, 3
After 300 ml) the filtrate was lyophilized in vacuo.

[0031] Histamine release inhibition test: Report by Hirai et al. (
Journal of Pharmaceutical Sciences, 37, 374, 1983. ), the inhibitory effect on histamine release on mast cells collected intraperitoneally from male Spraque-Dawley rats (200 to 450 g) was measured. That is, the effect of suppressing histamine release by 4 ppm of compound 48/80 was determined as release inhibition rate (%). The results are shown in Table 2. From these results, it was found that the hot water extract of the whole plant of Ichiyakusou or Rubus japonica obtained in Examples 1 and 2 had a remarkable effect of suppressing histamine release compared to the loofah water and the hot water extract of Kidachialoe. It was found that it has excellent anti-inflammatory effects. Furthermore, the water-soluble solvent extracts of the whole plants of Aspergillus japonica, Rusticum japonica, or Zinja japonica obtained in Examples 3 to 5 were also tested in the same manner, and were found to exhibit good anti-inflammatory effects. (Margin below)

[0032]

[Table 2]

Efficacy Test Example 4 Usage Test A usage test was conducted using 30 healthy subjects. As samples, the cosmetics of Examples 6 and 7 were used, and the weight percent of the water-soluble solvent extract of the whole plant of Aspergillus japonica or Asus annuus was varied. A 2 cm square site on the inner side of the subject's forearm was irradiated with ultraviolet light at an intensity of 3 mW/cm 2 for 1 minute using a UV-B lamp (Toshiba FL-20SE). Each sample was applied to each site twice a day in the morning and evening for three days, and then the anti-inflammation effect was evaluated through a questionnaire survey. A questionnaire survey was also conducted to evaluate the pigmentation suppressing effect after one month of use. Note that one site that was irradiated with ultraviolet rays was used as a control in which nothing was applied. The evaluation criteria for the questionnaire was to rate effective items as ``excellent'', somewhat effective items as ``good'', slightly effective items as ``fair'', and ineffective items as ``poor'', and compare them with controls. We conducted an evaluation.

The results are shown in Tables 4 and 5. These results show that the cosmetic used in the present invention exhibits a remarkable effect of suppressing post-sunburn inflammation and pigmentation. (Margin below)

[0035]

[Table 4]

(Margin below)

[0036]

[Table 5]

Efficacy Test Example 5 Safety Test In order to clarify the safety of the water-soluble solvent extract of the whole plant of Ichiyakuso of the present invention, a primary irritation test on humans was conducted by an occlusive patch test. That is, the fin chamber (E
PITEST) was applied to 30 healthy people on the flexor side of the forearm for 48 hours, and the average value of the results 1 hour, 24 hours, and 48 hours after removal of the patch test bandage was calculated. The judgment was made using The water extract obtained in Example 1 was used as a sample, the coating concentration was 10% (W/W) aqueous solution, and distilled water was used as a control. As a result of the evaluation, no erythema was observed in the aqueous extract of the whole plant of Ichiyakusou, while slight erythema was observed in 5 subjects in the case of the control distilled water. These results confirmed that the aqueous extract of the whole plant of Ichiyakusou has extremely low primary irritation and is highly safe for the skin. In addition, the water-soluble solvent extracts of the whole plant of Aspergillus japonica, Ruscus japonica, or Zinja japonica obtained in Examples 2 to 5 were similarly tested and found to be similarly highly safe for the skin. .

Claims (1)

[Claims] 1. A cosmetic product containing a water-soluble solvent extract of a whole plant of a plant belonging to the family Alocataceae.