KR20020080657A - Cosmetics comprising Albizzia bark extracts for antioxidation - Google Patents

Abstract

PURPOSE: An antioxidant cosmetic containing an Albizzia julibrissin Duraz. extract as a main component is provided. Because the extract is low in skin irritation and stability during mixing and shows an excellent free radical scavenging effect, it can provide an antioxidant cosmetic having an excellent prevention effect on wrinkles and skin aging. CONSTITUTION: The extract is prepared by extracting Albizzia julibrissin Duraz. in C1-3 anhydrous or hydrous alcohol, or ethyl acetate at 4 to 30deg.C for 3 to 20 days and then concentrating, wherein before or after execution of the extraction process, a diethylether soluble component is removed from the extract. The antioxidant cosmetic contains 0.0001 to 5% by weight of an Albizzia julibrissin Duraz. extract, based on the total dried weight of the antioxidant cosmetic.

Description

Cosmetics comprising Albizzia bark extracts for antioxidation

The present invention relates to an antioxidant cosmetic containing the haphwanpi extract.

Free radical theory was proposed by D. Harman in the mid-1950s and has recently attracted attention in the academic and related industries. Free radicals mean molecules and atoms that have secondary electrons in their outermost orbital electrons that are not paired and in a single electron (sub electron). Oxidation is the act of taking away one electron from another atom or molecule in order to enter a stable state by forming a molecule and valence team with this secondary electron. Radicals exist in the human body for a number of reasons. These radicals destroy cells, cut connective tissue in the dermal layer of the skin, or cause cross-linking, resulting in wrinkles, skin cancer, cell killing, rheumatoid arthritis, atopic dermatitis, It can cause various problems such as acne. Antioxidants play a role in preventing or oxidizing cells by eliminating or neutralizing these free radicals. Antioxidants include beta carotene, vitamin C, vitamin E, catechin, and proanthocyanination. Radicals are produced by the phagocytosis of leukocytes, the electron transport system during the production of ATP in mitochondria, the action of Myeloper Oxide (MPO), ultraviolet light, tobacco, normal metabolic processes, stress, pollutants, bacteria, and the like.

Of course, the human body also contains an antioxidant (radical scavenger), SuperOxide Dismatase (SOD), catalase, vitamin E, vitamin C, and ubiquinol. Increasingly, however, antioxidant systems begin to break down due to age, pollution, ultraviolet light, and stress. Thus the antioxidant system is neutralized and the radicals increase gradually.

The increased radicals destroy the dermal connective tissues, Collagen, Elastin and Hyaluronic acid, causing subsidence of certain areas of the skin (wrinkling), and also oxidizing the lipid part of the cell membrane to destroy cells. It causes symptoms such as dermatitis, acne, and skin cancer. In addition, this radical is involved in the spontaneous oxidation reaction (dopaquinone → melanin) during melanin formation, causing spots, freckles, and wrinkles. Therefore, conventionally, ascorbic acid, α-tocopherol, SOD, and the like have a free radical scavenging effect and are formulated into cosmetics or medicines to prevent wrinkles and other skin diseases. It has been used as, but not only the price is expensive but there is a problem that it is difficult to obtain a practical effect because the stability is not good at the time of formulation.

Accordingly, the present inventors have completed the present invention by searching for several natural products as a part of the research to solve the above problems and to find a better raw material, and found that the extract of Haphwanpi is excellent as a radical scavenger.

Therefore, an object of the present invention is to provide an antioxidant cosmetic containing a synthetic ring extract.

The present invention relates to an antioxidant cosmetic containing haphwanpi extract, characterized in that the hwanhwanpi extract is contained in 0.0001 to 5% by weight, preferably 0.001 to 3% by weight relative to the total dry weight of the antioxidant and cosmetics. It is difficult to obtain the practical effect of radical elimination when the haphwanpi extract is less than 0.0001% by weight relative to the total dry weight of the acid and cosmetics, and when the concentration is more than 5% by weight, the product stability is adversely affected.

Haphwanpi (地 楡) refers to the bark of Albizzia julibrissin Dura, a legume (Leguminosae) plant. Hwanhwanpi extract can be used in folk medicine and oriental medicine to soothe sedatives, diuretics, pain medications, fractures, swelling, swelling, to balance blood, to calm the mind and to remove swelling, tumors, mammary cancer, plasters, tonics, excitement, Used for diuresis. (Reference: Ingredients and Use of Herbs (Ilwol Seok. 1994. Encyclopedia of Science Encyclopedia), New Medicine Botany (Hakchangsa, 1991), Dictionary Agreement (Korean Dictionary Researcher), Chinese Dictionary of Translation of Chinese Medicine Dictionary Jeongdam, 1997).

In addition, the components of the compound skin include Albizzin, Alkaloid, Tannin, Saponin, Bixin, Quecetin, Vitamin, Vitamin A, Arachinic acid, etc. (See: Herbal Ingredients and Their Uses (Janwol Seokji, 1994. Encyclopedia of Science Encyclopedia)).

The haphwanpi extract can be prepared by extracting dried hwanhwanpi with anhydrous or hydrous alcohol having 1 to 3 carbon atoms, or ethyl acetate at 4 to 30 ° C. for 3 to 20 days, and then concentrating.

In addition, the hwanhwanpi extract may be prepared by extracting hwanhwanpi with water, anhydrous or hydrous alcohol having 1 to 3 carbon atoms, or ethyl acetate for 3 to 24 hours at 50 to 100 ℃, and then concentrated.

Meanwhile, the diethyl ether soluble component may be removed before or after performing the extraction process, and then concentrated to prepare a more purified Hwanhwanpi extract.

In the extraction process, it is preferable to use finely pulverized blood, and the extraction solvent is added at a volume of 1 to 15 times the weight of the sample, and the extraction is carried out by mounting a cooling condenser to prevent evaporation of the active ingredient. desirable.

Haphwanpi extract prepared as described above may be added to a conventional basic cosmetics, for example, soft cosmetics (skin), nutritious cosmetics (milk lotion), nutrition cream, massage cream, essence, pack, etc. can be prepared as an antioxidant cosmetic .

Hereinafter, the present invention will be described in more detail with reference to the following Examples and Experimental Examples, but the present invention is not limited thereto.

Example 1.

Finely pulverized 100g of hwanhwanpi was put in 1L of 70% ethyl alcohol, immersed for 10 days at room temperature and extracted, filtered through 300 mesh filter paper and left for 1 week, and the precipitate was filtered twice with filter paper of Adventech No. 7. And it concentrated completely at 50 degreeC using the vacuum concentrator, and obtained the dry weight 13.93g.

Example 2.

Finely pulverized 100g of hwanhwanpi was put in 1L of 30% ethyl alcohol, immersed for 10 days at room temperature, extracted, filtered with 300 mesh filter paper, and left for 1 week, and the precipitate was filtered twice with filter sheet of Adventech 7. Then, the resultant was concentrated completely at 50 ° C. using a vacuum concentrator to obtain a dry weight of 14.16 g.

Example 3.

Finely chopped 100g of hwanhwanpi in 1% of 70% ethyl alcohol, boiled at 100 ℃ in an extractor equipped with a cooling condenser for 8 hours, extracted with 300 mesh filter paper and left for 1 week, the precipitate was filtered twice by filter with Adventech No. 7 filter paper. . Then, the resultant was concentrated completely at 50 ° C. using a vacuum concentrator to obtain a dry weight of 11.76 g.

Example 4.

Finely chopped 100g of hwanhwanpi in 1L of 30% ethyl alcohol and boiled at 100 ℃ in an extractor equipped with a cooling condenser for 8 hours, extracted with 300 mesh filter paper and left for 1 week, the precipitate was filtered twice with filter No. 7 of Edbentech. . And it concentrated completely at 50 degreeC using the vacuum concentrator, and obtained the dry weight 6.32g.

Example 5.

Finely chopped 100g of hwanhwanpi in 1% of 70% ethyl alcohol, boiled at 100 ℃ in an extractor equipped with a cooling condenser for 8 hours, extracted with 300 mesh filter paper and left for 1 week, the precipitate was filtered twice by filter with Adventech No. 7 filter paper. . 1L of diethyl ether was added to the mixture, and the mixture was thoroughly separated. The mixture was separated into two layers. Then, 1L of ethyl acetate was added to the lower aqueous layer, mixed well. The mixture was separated into two layers, and the ethyl acetate layer was separated using a reduced pressure concentrator. Concentration completely to ° C. gave 2.78 g of dry weight.

Experimental Example 1.

Free Radical scavenging effect was measured on the extract of Hailhwanpi, and vitamin C was used as a comparative substance.

1) Experiment Method

Experiments were performed using the DPPH (1,1-diphenyl-2picryl-hydrazyl) method (Blois.M.S. Nature 181,1190,1958), and DPPH was used by SIGMA. To 1 ml of 0.2 mM DPPH methanol solution, 2 ml of ethanol or methanol solution of various concentrations (0.0006, 0.0012, 0.0024,0.0036, 0.0048, 0.0060% w / v) or ethanol or methanol solution of vitamin C were added and stirred well for 10 minutes at room temperature. Let reaction. The absorbance was measured at 517 nm, and purified water was used instead of the Hwanhwan skin extract as a control.

The free radical scavenging effect was obtained using Equation 1 below and the results are shown in Table 1 below.

2) Experiment result

Free radical scavenging effect of Haphwanpi extract Experimental substance Final experiment concentration (%) Free radical scavenging rate (%) SC ₅₀ Example 1 0.006% 90.53% 0.0033V Example 2 0.006% 91.26% 0.0031% Example 3 0.006% 90.45% 0.0025% Example 4 0.006% 91.49% 0.0025% Example 5 0.006% 91.46% 0.0010% Vitamin c 0.002% 91.28% 0.0009%

SC ₅₀ : concentration of the sample that eliminates 50% of free radicals (50% scavenging

Concentration

As can be seen in Table 1, the free radical 50% scavenging concentration (SC ₅₀ ) of Example 5 Hailpi skin extract was 0.001% and vitamin C was 0.0009%. However, considering that the vitamin C is unstable, it can be seen that the free radical scavenging effect of the haphwanpi extract (Example 5) is more excellent.

Prescription Example 1.

Prescription example of supple cosmetics (skin) in the cosmetics containing the haphwanpi extract is as follows, where the hwanhwanpi extract is obtained in Example 1.

ingredient Content (% by weight) Schist extract 3.0 Butylene glycol 4.0 glycerin 8.0 Carboxy Vinyl Polymer 0.06 Disodium ethylenediaminetetraacetic acid 0.01 ethanol 7.0 Triethanolamine 0.2 Sorbitan monostearate 0.8 Hydrogenated Castor Oil 0.4 Phenyltrimethicone 3.5 antiseptic 0.4 Spices 0.1 Pigment 0.01 Purified water Remaining amount system 100.0

Prescription Example 2

Prescription example of a lotion in the cosmetic containing the extract of hwanhwanpi is as follows, where hwanhwanpi extract refers to that obtained in Example 1.

ingredient Content (% by weight) Schist extract 3.0 Stearic acid 1.0 Cetyl alcohol 1.0 Glyceryl Monostearate 1.0 Polyoxyethylene sorbitan monostearate 1.0 Sorbitan sesquioleate 1.0 Liquid paraffin 4.0 Squalane 3.0 Carlylic / Capric Triglycerides 4.0 Carboxy Vinyl Polymer 0.1 Butylene glycol 5.0 Triethanolamine 0.2 antiseptic 0.4 Spices 0.1 Pigment 0.01 Purified water Remaining amount system 100.0

Prescription Example 3

Prescription example of nutrition cream in the cosmetic containing the extract of hwanhwanpi is as follows, where hwanhwanpi extract refers to that obtained in Example 1.

ingredient Content (% by weight) Schist extract 5.0 Stearic acid 2.0 Cetyl alcohol 2.0 Glyceryl Monostearate 2.0 Polyoxyethylene sorbitan monostearate 0.5 Sorbitan sesquioleate 0.5 Glyceryl Monostearate / Glyceryl Stearate / Polyoxyethylene Stearate 1.0 Wax 1.0 Liquid paraffin 4.0 Squalane 4.0 Carlylic / Capric Triglycerides 4.0 Carboxy Vinyl Polymer 0.3 Butylene glycol 5.0 glycerin 3.0 Triethanolamine 0.5 antiseptic 0.4 Spices 0.1 Pigment 0.01 Purified water Remaining amount system 100.0

Unlike the existing free radical scavenging substances, Hwanhwan Phi extract according to the present invention is an ingredient extracted from natural products, so it has less skin irritation, excellent free radical scavenging effect, and excellent stability when formulated to provide an excellent antioxidant cosmetic for preventing wrinkles and skin aging. Can provide.

Claims (6)

Antioxidant cosmetics, including Haphwanpi extract. The antioxidant cosmetic composition according to claim 1, wherein the extract of hwanhwanpi is contained in an amount of 0.0001 to 5% by weight based on the total dry weight of the antioxidant cosmetic. The anti-oxidant cosmetic according to claim 1, wherein the extract of hwanhwanpi is prepared by extracting hwanhwanpi with anhydrous or hydrous alcohol having 1 to 3 carbon atoms or ethyl acetate at 4-30 ° C for 3 to 20 days, and then concentrating. . The method of claim 1, wherein the extract of hwanhwanpi is prepared by extracting hwanhwanpi with water, anhydrous or hydrous alcohol having 1 to 3 carbon atoms, or ethyl acetate at 50-100 ° C for 3 to 24 hours, and then concentrating. Antioxidant cosmetics. The antioxidant cosmetic composition according to claim 3 or 4, wherein the extract of Hwanhwan Phi is prepared by removing the diethyl ether soluble component before or after performing the extraction process and then concentrating. The antioxidant cosmetic composition according to claim 1, wherein the extract of Hwanhwan Phi is added to the formulation selected from flexible lotion, nutrition lotion, nutrition cream, massage cream, essence or pack.