KR100499999B1 - Free radical scavenging cosmetics containing Chang-zai extract - Google Patents
Free radical scavenging cosmetics containing Chang-zai extract Download PDFInfo
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Abstract
본 발명은 창이자(도꼬마리)의 추출물을 함유하는 자유라디칼 소거 화장료로서, 창이자는 국화과(compositae)의 도꼬마리(xanthium strumarium LINNAEUS)열매임을 특징으로 하는 화장료이다.The present invention is a free radical scavenging cosmetic containing an extract of Chang-za (Sknot), which is a cosmetic characterized in that it is a fruit of xanthium strumarium LINNAEUS (compositae).
Description
본 발명은 창이자(도꼬마리)를 함유하는 자유라디칼 소거 화장료에 관한 것이다.The present invention relates to a free radical scavenging cosmetic containing Chang-za.
자유라디칼 이론은 1950년대 중반 하만(D. Harman)에 의해서 제시되었으며, 최근들어 학회와 관련업계에서 많은 주목을 받고 있다. 자유라디칼이 인체에 존재하는 원인은 백혈구의 식작용, 미토콘드리아에서의 ATP 생산과정중 전자 전달계, 미에로퍼옥사이드(Myeloper Oxide, MPO)의 작용, 자외선, 흡연, 정상적인 대사과정, 스트레스, 공해물질, 세균 등 여러 가지가 있다. 이러한 자유라디칼은 세포를 파괴하거나 피부 진피층의 결합조직을 절단하거나 교차 결합을 일으키므로 주름형성, 피부암, 세포살상, 류마티스성 관절염, 아토피성 피부염, 여드름 등 다양한 문제를 발생시킨다.Free radical theory was proposed by D. Harman in the mid-1950s and has received a great deal of attention recently in academics and related industries. The causes of free radicals in the human body include the phagocytosis of leukocytes, the electron transfer system during the production of ATP in mitochondria, the action of myeloper oxide (MPO), ultraviolet light, smoking, normal metabolic processes, stress, pollutants, bacteria, etc. There are many ways. Such free radicals cause various problems such as wrinkle formation, skin cancer, cell death, rheumatoid arthritis, atopic dermatitis, and acne because they destroy cells, cut off connective tissue of the dermal layer, or cause crosslinking.
물론 인체에는 항산화물질(자유라디칼 소거제)인 SOD(SuperOxide Dismatase), 과산화수소 분해효소(Catalase), V-E, V-C, 유비퀴놀(Uviquinol)등이 있다. 그러나 항산화 체계는 노화, 공해, 자외선, 스트레스 등에 의해 깨져서 무력화되므로 자유라디칼이 점차 증가하게 된다.Of course, there are antioxidants (free radical scavengers) SOD (SuperOxide Dismatase), hydrogen peroxide (Catalase), V-E, V-C, ubiquinol (Uviquinol). However, the antioxidant system is broken down by aging, pollution, ultraviolet rays, stress, etc., so the free radicals gradually increase.
이 증가된 자유라디칼은 진피의 결합조직인 콜라겐(Collagen), 에라스틴(Elastin), 히아라론산(Hyalaronic acid) 등을 파괴하여 피부의 일정 부위 침하 현상(주름)을 일으키며, 또한 세포막의 지질 부분을 산화시켜 세포의 파괴 현상을 일으켜피부염, 여드름, 피부암등의 질병을 유발한다. 게다가 이 자유라디칼은 멜라닌 형성과정중 자동산화반응(DOPA→ 멜라닌)에 관여하여 기미, 주근깨 등의 원인 및 주름 생성의 원인이 되기도 한다.(대한 화장품학회지 23권 1호, 75~132) 따라서 종래 아스콜빈산, α -토코페롤, SOD 등이 자유라디칼 소거 효과를 가지는 물질로 화장료나 의약품에 배합되어 주름 및 기타 피부 질환을 방지하기 위하여 이용되어 왔지만 그 자체의 안정성과 경제적인 면에서 사용이 제한되고 있다.This increased free radical destroys the dermal connective tissues, Collagen, Elastin, and Hyalaronic acid, causing subsidence of the skin (wrinkle), Oxidation causes cell destruction and causes diseases such as dermatitis, acne and skin cancer. In addition, this free radical is involved in the automatic oxidation reaction (DOPA → melanin) during the melanin formation process, causing blemishes, freckles, and wrinkles (Korea Cosmetics Society Vol. 23 No. 1, 75 ~ 132). Ascorbic acid, α-tocopherol, SOD, etc. have free radical scavenging effect, and have been used in cosmetics and medicines to prevent wrinkles and other skin diseases. have.
본 발명자들은 이러한 현실을 감안하여 종래의 자유라디칼 소거제가 갖는 문제점을 극복하고 보다 우수한 원료를 찾고자 여러 천연물을 검색한 결과 창이자의 추출물이 자유라디칼 소거제로 우수한 효과가 있음을 알게되었다.In view of this reality, the present inventors have found that the extract of Chang-za is excellent as a free radical scavenger as a result of searching several natural products to overcome the problems of the conventional free radical scavenger and find a better raw material.
창이자는 국화과(compositae)의 도꼬마리(xanthium strumarium LINNAEUS)열매를 말한다. 도꼬마리는 1년생 초본이며, 높이 1m 안팎이고 잎과 더불어 털이 있다. 잎은 호생하며 염병이 길고 길이가 5~10cm이다. 꽃은 8~9월에 피고 꽃은 황색이며 가지 끝과 원 줄기 끝에 원추상으로 달리고 암꽃과 수꽃이 있으며 수꽃의 두상화서(頭狀花序)는 둥글고 끝에 달리며 암꽃의 두상화서는 밑부분에 달리고 2개의 돌기가 있다. 총포(總苞)는 갈고리 같은 돌기가 있고 타원형이며 길이 1cm 정도이다. 그 속에 2개의 수과(瘦果)가 들어 있다. 9월에 열매가 성숙되며 수과는 겉에 갈고리같은 돌기가 있어 물체에 잘 붙는다Chang-ja is the fruit of the xanthium strumarium LINNAEUS of the compositae. Docomari is an annual herb, is about 1m high and has hairs with leaves. The leaves are regenerated, the plague is long, and 5 ~ 10cm long. Flowers bloom in August-September, flowers are yellow with cones at the ends of branches and stems. There are female flowers and male flowers. There is a projection. The muzzle is a hook-like projection, elliptical, about 1cm long. There are two achenes (瘦果). Fruit matures in September, and the achene has a hook like an outer surface that adheres well to objects.
어린 순을 식용하며 열매(창이자)를 진통(鎭痛), 정종(丁腫), 금창(金瘡), 충독(蟲毒), 수종(水腫), 배농(排膿), 치질, 편도선염, 중풍, 광견병, 습진, 발한, 매독, 관절염, 해독, 이뇨, 산후통(産後痛), 치통, 명목(明目), 나력(나력), 두통의 치료에 사용하였다. 주로 살균고약, 방부고약을 만들어 습진, 태선, 선병, 종처, 뽀두라지, 천연두, 해양성 피부염에 이용하였다.(한국의 자원식물, 서울대학교 출판부, 1996)Young sprouts are eaten and fruit (spear) is analgesic, Jeongjong (丁 腫), Geumchang (金 瘡), Chungpok (수), Species (水腫), Dungong (치), Hemorrhoids, Tonsillitis, Stroke, Rabies Eczema, sweating, syphilis, arthritis, detoxification, diuresis, postpartum pain, toothache, nominal, nag, nag, headache. It is mainly used to make antiseptic plasters and antiseptic plasters for eczema, Taesun, sesame disease, boils, poduraji, smallpox, and marine dermatitis.
성분으로는 크산토스트루마린(xanthostrumain, 노란색배당체), 수지, 요오드염, 사포닌, 크산틴(xanthinin) 지방산 등이 있으며, 지방산은 리놀레인산, 올레인산, 포화지방산, 팔미틴산, 스테아린산 등으로 구성되어 있다.(약초의 성분과 이용, 일월서각, 1996; 한국의 자원식물, 서울대학교 출판부, 1996; 중약 대사전, 소학관, 일본, 1985)Ingredients include xanthostrumain (yellow glycosides), resins, iodine salts, saponins, and xanthinin fatty acids. The fatty acids consist of linoleic acid, oleic acid, saturated fatty acid, palmitic acid, stearic acid, etc. (Ingredients and Uses of Medicinal Herbs, Ilwol Seogwi, 1996; Korean Plant Resources, Seoul National University Press, 1996; Chinese Medicine Ambassador, Sohakkan, Japan, 1985)
본 발명의 목적은 창이자를 함유하는 자유라디칼 소거 화장료를 제공하는 것이다.An object of the present invention is to provide a free radical scavenging cosmetic containing a window.
본 발명은 창이자를 함유하는 자유라디칼 소거 화장료에 관한 것으로, 창이자를 유기용매로 추출한 추출물의 에틸아세테이트, 디에틸에테르 분획을 추출하여 화장료, 다시 말하면 로션, 영양크림, 맛사지크림, 엣센스, 팩 등에 첨가하는 것이다.The present invention relates to free radical scavenging cosmetics containing Chang-Chija, which is added to cosmetics, that is, lotions, nourishing creams, massage creams, essences, packs, etc. by extracting ethyl acetate and diethyl ether fractions of extracts extracted with Chang-Ji-Chang organic solvents. It is.
본 발명의 창이자 추출물은 화장료의 건조중량에 대하여 0.0001~5중량%, 바람직하게는 0.001~1중량%의 양으로 배합하여 사용한다.Changza extract of the present invention is used in an amount of 0.0001 to 5% by weight, preferably 0.001 to 1% by weight based on the dry weight of the cosmetic.
본 발명을 상세히 설명하면 다음과 같다.The present invention is described in detail as follows.
본 발명은 야생이나 재배된 창이자에 그 건조중량에 대해 물, 저급알코올, 아세톤, 에틸아세테이트, 부틸아세테이트, 클로로포름 등을 1~15배 부피량으로 가하고 냉각콘덴서가 장착되어 유효성분이 증발되는 것을 방지한 상태에서 50-100℃로 3~12시간 가열하여 추출하거나 4~30℃에서 5~15일간 침적시켜 유효성분을 추출한 후 여과지로 감압여과한 후, 0~20℃로 3~15일간 숙성시키고 다시 여과지로 감압 여과 및 자연여과하여 추출한다.The present invention adds 1 to 15 times the volume of water, lower alcohol, acetone, ethyl acetate, butyl acetate, chloroform and the like to the dry weight of wild or cultivated Changja, and is equipped with a cooling condenser to prevent evaporation of the active ingredient. After extracting by heating to 50-100 ℃ for 3-12 hours or by dipping at 4-30 ℃ for 5-15 days to extract the active ingredient, filtered under reduced pressure with a filter paper, then aged at 0-20 ℃ for 3-15 days and again Filtration under reduced pressure with filter paper and extraction by natural filtration.
이렇게 얻어진 추출물에 적당한 물을 가한 뒤 생기는 침전물을 여과하여 제거한 후, 디에틸에테르 또는 에틸아세테이트를 가하여 잘 섞은 다음 방치하여 층을 분리시킨 후 상층을 분리하여 추출한다. 이와 같이 추출한 추출물을 냉각 콘덴서가 달린 증류장치에서 30~90℃로 완전히 감압 농축하여 본 발명의 창이자추출물을 제조한다.After adding appropriate water to the extract thus obtained, the resulting precipitate was filtered off, and then diethyl ether or ethyl acetate was added, mixed well, and left to separate the layers, followed by extraction of the upper layer. The extract thus extracted is concentrated under reduced pressure completely to 30-90 ° C. in a distillation apparatus equipped with a cooling condenser to produce a changja extract of the present invention.
본 발명의 창이자추출물을 함유하는 자유라디칼 소거 화장료는 유연화장수, 영양화장수, 영양크림, 맛사지크림, 엣센스, 팩 등의 제형을 갖는다.The free radical scavenging cosmetic containing the extract of the present invention of the present invention has a formulation such as softening cream, nutrient cream, nourishing cream, massage cream, essence, pack and the like.
아래의 실시예 및 실험예들은 본 발명을 상세히 설명하지만, 본 발명이 이에 한정되는 것은 아니다.Examples and Experimental Examples below describe the present invention in detail, but the present invention is not limited thereto.
실시예 1Example 1
창이자 100g을 50% 에탄올 1L에 넣고 냉각 콘덴서가 달린 추출기에서 8시간 끓여서 추출한 후, 여과지로 감압여과하고, 4~10℃에서 5일간 방치하여 숙성시킨 후 여과지로 감압여과, 자연 여과 2회 여과했다. 이 추출물을 냉각콘덴서가 달린 증류장치에서 60℃로 감압 농축하여 건조중량 16.7g을 얻었다.Changiza 100g was added to 1L of 50% ethanol, extracted by boiling in an extractor equipped with a cooling condenser for 8 hours, filtered under reduced pressure with a filter paper, left to mature at 4 to 10 ° C for 5 days, then filtered under reduced pressure with a filter paper, and filtered twice with natural filtration. . The extract was concentrated under reduced pressure at 60 ° C. in a distillation apparatus equipped with a cooling capacitor to obtain a dry weight of 16.7 g.
실시예 2Example 2
창이자 100g을 메탄올 1L에 넣고 냉각 콘덴서가 달린 추출기에서 8시간 끓여서 추출한 후, 여과지로 감압여과하고, 4~10℃에서 5일간 방치하여 숙성시킨 후 여과지로 감압여과, 자연 여과 2회 여과했다. 이 추출물을 냉각콘덴서가 달린 증류장치에서 50℃로 감압 농축하여 건조중량 15.2g을 얻었다.Changgiza was put into 1 L of methanol, boiled in an extractor equipped with a cooling condenser for 8 hours, extracted, filtered under reduced pressure with a filter paper, left to mature at 4 to 10 ° C for 5 days, and filtered under reduced pressure with a filter paper and filtered twice with natural filtration. The extract was concentrated under reduced pressure at 50 ° C. in a distillation apparatus equipped with a cooling capacitor to obtain a dry weight of 15.2 g.
실시예 3Example 3
창이자 100g을 물 1L에 넣고 냉각 콘덴서가 달린 추출기에서 8시간 끓여서 추출한 후, 여과지로 감압여과하고, 4~10℃에서 5일간 방치하여 숙성시킨 후 여과지로 감압여과, 자연 여과 2회 여과했다. 이 추출물을 냉각콘덴서가 달린 증류장치에서 70℃로 감압 농축하여 건조중량 13.1g을 얻었다.Changgjaza 100g in 1L of water, boiled in an extractor with a cooling condenser for 8 hours, extracted, filtered under reduced pressure with a filter paper, left to mature for 5 days at 4 ~ 10 ℃, and filtered under reduced pressure with a filter paper, and filtered twice with natural filtration. The extract was concentrated under reduced pressure at 70 ° C. in a distillation apparatus equipped with a cooling capacitor to obtain a dry weight of 13.1 g.
실시예 4Example 4
창이자 100g을 메탄올 1L에 넣고 4~25℃에서 10일간 침적시켜 추출한 후, 여과지로 감압여과하고, 4~10℃에서 5일간 방치하여 숙성시킨 후 여과지로 감압여과, 자연 여과 2회 여과했다. 이 추출물을 냉각콘덴서가 달린 증류장치에서 50℃로 감압 농축하여 건조중량 11.6g을 얻었다.100 g of Changza was added to 1 L of methanol, and the mixture was immersed at 4 to 25 ° C. for 10 days to extract, filtered under reduced pressure with a filter paper, left to mature at 4 to 10 ° C. for 5 days, and then filtered under reduced pressure with a filter paper and filtered twice with natural filtration. The extract was concentrated under reduced pressure at 50 ° C. in a distillation apparatus equipped with a cooling capacitor to obtain a dry weight of 11.6 g.
실시예 5Example 5
창이자 100g을 에탄올 1L에 넣고 4~25℃에서 10일간 침적시켜 추출한 후, 여과지로 감압여과하고, 4~10℃에서 5일간 방치하여 숙성시킨 후 여과지로 감압여과, 자연 여과 2회 여과했다. 이 추출물을 냉각콘덴서가 달린 증류장치에서 60℃로 감압 농축하여 건조중량 10.7g을 얻었다.Changa 100 g of 1 liter of ethanol was deposited and extracted by dipping at 4 to 25 ° C. for 10 days, filtered under reduced pressure with a filter paper, left to mature for 5 days at 4 to 10 ° C., filtered under reduced pressure with a filter paper, and filtered twice with natural filtration. The extract was concentrated under reduced pressure at 60 ° C. in a distillation apparatus equipped with a cooling capacitor to obtain a dry weight of 10.7 g.
실시예 6Example 6
창이자 100g을 50% 에탄올 1L에 넣고 4~25℃에서 10일간 침적시켜 추출한 후, 여과지로 감압여과하고, 4~10℃에서 5일간 방치하여 숙성시킨 후 여과지로 감압여과, 자연 여과 2회 여과했다. 이 추출물을 냉각콘덴서가 달린 중류장치에서 60℃로 감압 농축하여 건조중량 13.3g을 얻었다.Changa 100 g of 50% ethanol was added to 1 L of 50% ethanol and extracted by dipping for 10 days, filtered under reduced pressure with a filter paper, left to mature for 5 days at 4-10 ° C, filtered under reduced pressure with a filter paper, and filtered twice with natural filtration. . The extract was concentrated under reduced pressure at 60 ° C. in a midstream apparatus equipped with a cooling capacitor to obtain a dry weight of 13.3 g.
실시예 7Example 7
창이자 100g을 30% 에탄올 1L에 넣고 4~25℃에서 10일간 침적시켜 추출한 후, 여과지로 감압여과하고, 4~10℃에서 5일간 방치하여 숙성시킨 후 여과지로 감압여과, 자연 여과 2회 여과했다. 이 추출물을 냉각콘덴서가 달린 증류장치에서 60℃로 감압 농축하여 건조중량 12.5g을 얻었다.Chang-Za 100 g in 1 L of 30% ethanol was extracted by immersion for 10 days at 4-25 ° C, extracted under reduced pressure with a filter paper, left to mature for 5 days at 4-10 ° C, filtered under reduced pressure with a filter paper, and filtered twice with natural filtration. . The extract was concentrated under reduced pressure at 60 ° C. in a distillation apparatus equipped with a cooling capacitor to obtain a dry weight of 12.5 g.
실험예 1 : 창이자 추출물의 자유라디칼 소거 효과Experimental Example 1: Free radical scavenging effect of the extract
0.2mM DDPH 메탄올 용액 1ml에 여러 농도의 메탄올, 에탄올 용액 0.2ml를 첨가하고 잘 섞은 후 실온에서 10분간 방치한 후 517nm에서 흡광도의 감소를 측정하였다. 그 결과를 아래 표1에 기재하였다.To 1 ml of 0.2 mM DDPH methanol solution, 0.2 ml of various concentrations of methanol and ethanol solution were added, mixed well, and left at room temperature for 10 minutes, and then the decrease in absorbance was measured at 517 nm. The results are shown in Table 1 below.
[표 1]TABLE 1
창이자추출물의 자유라디칼 소거 효과Free radical scavenging effect of changja extract
계산식: 1-((A-A0)/(B-B0))Calculation: 1-((AA 0 ) / (BB 0 ))
A:(시료 + DPPH)의 흡광도Absorbance of A: (Sample + DPPH)
A0:(시료 + DPPH의 용매)의 흡광도Absorbance of A 0 : (Sample + Solvent of DPPH)
B:(DPPH + 시료용매)의 흡광도Absorbance of B: (DPPH + Sample Solvent)
B0:(DPPH의 용매 + 시료용매)의 흡광도B 0 : (absorbance of (DPPH solvent + sample solvent)
처방예 1Prescription Example 1
창이자 추출물을 함유한 화장료 중 유연화장수의 처방예는 다음과 같다. 여기서 창이자 추출물은 실시예 1의 것을 말한다.A prescription example of the flexible cosmetic water in the cosmetic containing the Changiza extract is as follows. Here Changchang extract refers to that of Example 1.
처방예 2Prescription Example 2
창이자 추출물을 함유한 화장료 중 로션의 처방예는 다음과 같다. 여기서 창이자 추출물은 실시예 1의 것을 말한다.A prescription example of a lotion in a cosmetic containing a Changiza extract is as follows. Here Changchang extract refers to that of Example 1.
처방예 3Prescription Example 3
창이자추출물을 함유하는 화장료 중 영양크림의 처방예는 다음과 같다. 여기서 창이자추출물은 실시예 1의 것을 말한다.Prescription examples of nutritional cream among cosmetics containing Changja extract are as follows. Here, the window extracts refer to those of the first embodiment.
처방예 4Prescription Example 4
창이자추출물을 함유하는 화장료 중 맛사지크림의 처방예는 다음과 같다. 여기서 창이자추출물은 실시예 1의 것을 말한다.A prescription example of a massage cream among cosmetics containing Changiza extract is as follows. Here, the window extracts refer to those of the first embodiment.
처방예 5Prescription Example 5
창이자추출물을 함유하는 화장료 중 팩의 처방예는 다음과 같다. 여기서 창이자추출물은 실시예 1의 것을 말한다.A prescription example of a pack among cosmetics containing Chang-za extract is as follows. Here, the window extracts refer to those of the first embodiment.
본 발명의 창이자추출물을 함유하는 자유라디칼 소거용 화장료는 자유라디칼 소거 작용이 뛰어나고 각종 화장료에 배합하여 사용이 가능하다.The free radical scavenging cosmetic containing the extract of the present invention is excellent in free radical scavenging action and can be used in combination with various cosmetics.
Claims (7)
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| Application Number | Priority Date | Filing Date | Title |
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| KR1019970046262A KR100499999B1 (en) | 1997-09-09 | 1997-09-09 | Free radical scavenging cosmetics containing Chang-zai extract |
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| KR1019970046262A KR100499999B1 (en) | 1997-09-09 | 1997-09-09 | Free radical scavenging cosmetics containing Chang-zai extract |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010062103A2 (en) * | 2008-11-26 | 2010-06-03 | Yang Gean Yung | Topical skin composition and method for preparing same |
| US9271504B2 (en) | 2005-11-28 | 2016-03-01 | Board Of Trustees Of Michigan State University | Insecticidal compositions and uses thereof |
| KR20230149057A (en) | 2022-04-19 | 2023-10-26 | 주식회사 단정바이오 | Cosmetic composition containing roasted Changija extract as an active ingredient to have antioxidant and anti-inflammatory effects |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030077745A (en) * | 2002-03-26 | 2003-10-04 | 안창국 | Functional cosmetic manufacturing method |
| KR100791244B1 (en) * | 2006-12-21 | 2008-01-03 | 한선희 | Contact lens preservatives containing xanthium strumarium l. extracts as effective constituent |
| KR101056756B1 (en) * | 2010-12-17 | 2011-08-12 | 주식회사 사임당화장품 | Cosmetic composition containing herb medicine extracts |
| KR102306737B1 (en) * | 2015-12-29 | 2021-09-28 | 김수현 | Antioxidant food comprising extracts of fresh sprouts of Xanthium canadense Mill. |
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1997
- 1997-09-09 KR KR1019970046262A patent/KR100499999B1/en not_active IP Right Cessation
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9271504B2 (en) | 2005-11-28 | 2016-03-01 | Board Of Trustees Of Michigan State University | Insecticidal compositions and uses thereof |
| WO2010062103A2 (en) * | 2008-11-26 | 2010-06-03 | Yang Gean Yung | Topical skin composition and method for preparing same |
| WO2010062103A3 (en) * | 2008-11-26 | 2010-12-16 | Yang Gean Yung | Topical skin composition and method for preparing same |
| KR20230149057A (en) | 2022-04-19 | 2023-10-26 | 주식회사 단정바이오 | Cosmetic composition containing roasted Changija extract as an active ingredient to have antioxidant and anti-inflammatory effects |
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| KR19990024886A (en) | 1999-04-06 |
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