KR20100049155A - A cosmetic composition for stabilizing vitamin c - Google Patents

Abstract

PURPOSE: A cosmetic composition containing plant anti-oxidant is provided to minimize discoloration and odor deterioration and to maximize active ingredient effect. CONSTITUTION: A cosmetic composition with stabilized vitamin C contains Forsythia suspense Vahl extract, Angelica gigas Nakai extract, or vitamin C mixture thereof. The Forsythia suspense Vahl and Angelica gigas Nakai extract is contained in 0.01-10.0 weight% based on total weight. The mass ratio of Forsythia suspense Vahl extract and Angelica gigas Nakai extract is 1:1. The cosmetic composition is used in the form of skin, lotion, essence, cream, pack, gel, ointment, patch, or spray.

Description

Cosmetic composition for stabilizing vitamin C {a cosmetic Composition for stabilizing Vitamin C}

The present invention relates to a cosmetic composition stabilized with vitamin C containing a vegetable antioxidant, specifically by at least one of Forsythia Fructus extract and Angelica gigas Nakai extract, which is a plant antioxidant having excellent antioxidant power It is to provide excellent antioxidant cosmetics that can stabilize or prevent skin aging by stabilizing vitamin C.

There are many theories explaining the aging of the skin, but among them, the free radical theory that the skin ages by the free radicals generated by various factors in and out of the body is accepted as the most valid theory. Free radicals are chemically highly reactive chemicals that occur when the skin is irradiated with UV light or during the respiration of cells in the skin. Most of the free radicals associated with aging of the skin are Reactive Oxygen Species (ROS), which include Superoxide Radical, Hydrogen Peroxide, Hydroxy Radical, and Sun. Singlet Oxygen and the like.

The goal of antioxidant cosmetics is to maintain healthy skin and to delay the aging of skin that occurs naturally with age. To this end, research is being actively conducted to develop materials having excellent safety and cosmetic beauty by searching for skin physiological activity of various natural plant components.

Materials known to have antioxidant activity so far include ascorbic acid, DL-a-tocopherol, beta-carotene, dibutylhydroxytoluene (BHT), and the like.

These materials have raised the issue of skin safety and stability, and the development of new antioxidant cosmetics that can be applied to the skin more safely and usefully is urgently required.

On the other hand, vitamin C is known to have a variety of physiological functions such as acting as an enzyme coenzyme (enzymatic co-factor) in vivo, and acts as an antioxidant. In particular, the use of a large amount of vitamin C is known to have a whitening effect and skin aging effect. When used at high doses, vitamin C reacts with superoxide and hydroxyl radicals. Superoxide and hydroxyl radicals are oxygen-containing activator oxygen that can be produced in a steady state or diseased state, acting as a causative agent when the skin is blackened by ultraviolet rays or when skin ages. However, vitamin C has a double bond between carbon 2 and carbon 3, and has hydrogen (pK = "4.2) where acid-ionization reactions can occur in the presence of water. It becomes a compound of unstable anion form under high condition.The instability of vitamin C is a problem of discoloration and potency when vitamin C is added to cosmetics as a solution, and the stereochemical stress due to polar repulsive force, ascorbic acid Oxidative decomposition by anions and decomposition due to water attack are considered to be the cause.

Therefore, various methods have been considered to stabilize such unstable vitamin C. In the conventional method, a method using a very low concentration of vitamin C, a non-aqueous solvent, or using various derivatives of vitamin C is used. Etc.

The vegetable antioxidant used in the present invention is an extract known as an antioxidant as a duct extract and a Angelica extract. Forsythia Fructus is a fruit of the Euphoria forsythia, belonging to the ash family, with a narrow egg shape, short beak at the end, and split into two pieces when fully cooked. It has been used as an anti-inflammatory and drainage skin disease agent in Chinese medicine, and among the substances extracted and separated from ducts, matareresinol, actigenin or a mixture thereof is known to be very effective for skin wrinkle improvement.

Angelica gigas Nakai is a perennial vegetation belonging to the Buttercup family and has been widely used as a medicinal herb since it is considered to be non-toxic among herbs. Angelica is used as a medicinal herb for gynecologic diseases such as cold and anemia. It is used to facilitate blood circulation and to improve hematopoiesis and blood flow.

Yeongyo extract and Angelica extract are used as natural medicines, but little research has been conducted to stabilize other antioxidants.

Therefore, the present inventors have made efforts to develop a cosmetic composition for stabilizing vitamin C, which is easily oxidized by containing vegetable antioxidants, and is very unstable. As a result, vitamin C by Forsythia Fructus extract and / or Angelica gigas Nakai extract It has been found that stabilization can prevent or delay skin aging. Moreover, duct extract and / or Angelica extract completed the present invention by confirming the synergistic effect of inhibiting the skin aging phenomenon by playing a role as a vegetable antioxidant and a role to stabilize the vitamin C.

In order to solve the above problems, the present invention provides the following means.

Vitamin C stabilized cosmetic composition according to an embodiment of the present invention is characterized in that it contains one extract and vitamin C selected from Yeongyo extract, Angelica extract or Yeongyo and Angelica extract as an active ingredient.

The extract is characterized in that it is contained in 0.01 to 10.0% by weight based on the total weight of the cosmetic composition.

In addition, the pontoon extract and Angelica extract is characterized in that the weight ratio of the duct extract: Angelica extract is mixed 1: 1.

On the other hand, the cosmetic composition stabilized vitamin C according to the present invention has an antioxidant power, characterized by stabilizing discoloration, discoloration, potency of vitamin C.

And, the cosmetic composition, characterized in that formed in any one formulation selected from the group consisting of lotion, essence, lotion, cream, pack, gel, ointment, patch, or spray.

The present invention relates to a cosmetic that can have excellent antioxidant power by preventing oxidation of vitamin C by containing at least one extract of Forsythia Fructus and Angelica gigas Nakai, which are plant antioxidants having excellent antioxidant activity. The cosmetic composition of the present invention is very unstable in heat, light, air, discoloration and odor occurs, and vitamin C, which has a problem of potency, minimizes discoloration and odor through vegetable antioxidants and greatly increases the antioxidant effect through maintaining the titer. The effect of the active ingredient is maximized and the stability of the formulation is greatly improved. In addition, these vegetable antioxidants have antioxidant properties in themselves, which can be used more safely and usefully on the skin than conventional synthetic antioxidants, and have a synergistic effect with vitamin C having excellent antioxidant properties. Can be prevented.

Hereinafter, the present invention will be described in detail.

The present invention relates to a cosmetic composition stabilized vitamin C by containing as an active ingredient extract and one of the extract selected from Yeongyo extract, Angelica extract, and Yeongyo and Angelica extract as an active ingredient.

The fragrance and / or Angelica extract have an antioxidant effect and do not show skin irritation, which may help stabilize the vitamin C when used in cosmetics containing vitamin C.

Yeongyo and / or Angelica extract used as an active ingredient in the present invention may be prepared as follows.

The duct and donkey are washed with water, and then dried in the shade. Dry pulverized bridge and Angelica are pulverized into fine powder, placed in an extraction container, and extracted for a predetermined deposition time at an appropriate deposition temperature in an appropriate amount of extraction solvent. The extract can be filtered and concentrated using a vacuum rotary evaporator or the like.

As the extraction solvent, a polar solvent selected from water (purified water), a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof may be used. The amount of the extraction solvent is preferably 1 to 15 L of the extraction solvent based on 1 kg of the dry weight of the herbal medicine.

On the other hand, it will be apparent to those skilled in the art that the extract of the present invention can be obtained not only the above-described extraction solvent, but also soft-core and / or sugar extracts which exhibit substantially the same effect using other extraction solvents.

The deposition temperature is 40 ~ 80 ℃, more preferably 60 ~ 80 ℃, most preferably maintained at about 70 ℃ is most effective in the prevention of decay, discoloration and odor.

The immersion time is preferably to extract the active ingredient for 2 to 6 hours by the method of bath.

Extracts of the present invention may be prepared in powder form by additional processes such as distillation under reduced pressure and freeze drying or spray drying. The solution thus extracted is concentrated under reduced pressure to form a duct extract and a Angelica extract, which are preferably dissolved in a concentration of 0.1% to 10% in 100% ethanol solution.

In addition, the extract of the present invention includes not only the extract by the above-mentioned extraction solvent, but also the extract that has undergone a conventional purification process. Obtained through a variety of additional purification methods, such as, for example, separation using an ultrafiltration membrane having a constant molecular weight cut-off value, separation by various chromatography (manufactured for different separation in size, charge, hydrophobicity or affinity). The fraction is also included in the extract of the present invention.

In the present invention, the amount of soft duct extract and / or Angelica extract contained as an active ingredient is 0.01 to 10.0% by weight, preferably 0.1 to 5.0% by weight based on the cosmetic. If the content of the extract is less than 0.01% shows little stabilizing effect of the vitamin C, if more than 10% by weight increase of the effect of the increase in the content is insignificant and may cause problems in the stability of the cosmetic.

In addition, the weight ratio of the mixture of the duct extract and the Angelica extract may be variously formed, preferably, the weight ratio of the duct extract: Angelica extract is preferably 1: 1.

On the other hand, the vitamin C contained as an active ingredient in the present invention is prevented from being oxidized by the duct and / or Angelica extract, the content of the vitamin C may be contained in an amount that can be commonly used in the field of dermatology cosmetic composition It is preferable to contain 0.001-20.0 weight% with respect to the total weight.

On the other hand, the weight ratio of the duct extract and / or Angelica extract and vitamin C may be formed in various ratios within the range that does not inhibit the effect of the present invention to obtain the antioxidant of vitamin C.

The composition of the present invention may further contain at least one active ingredient exhibiting the same or similar function in addition to the duct extract and / or Angelica extract and vitamin C.

Cosmetics prepared by the cosmetic composition containing the duct extract and / or Angelica extract and vitamin C of the present invention as an active ingredient can be prepared in the form of a general emulsion formulation and solubilized formulation. Cosmetics of the emulsified formulations include nutrient cosmetics, creams, essences, etc., and cosmetics of the solubilized formulations are flexible cosmetics. In addition, in addition to cosmetics containing the duct extract and / or Angelica extract and vitamin C of the present invention by containing a dermatologically acceptable medium or base in the form of supplements for topical or systemic application commonly used in the field of dermatology Can be prepared.

Suitable cosmetic formulations include, for example, emulsions, suspensions, microemulsions, microcapsules, microgranules or ionics (liposomes), nonionics obtained by dispersing an oil phase in a solution, gel, solid or pasty anhydrous product, aqueous phase. It may be provided in the form of a vesicle dispersant, in the form of a cream, skin, lotion, powder, ointment, spray or conceal stick. It may also be prepared in the form of a foam or in the form of an aerosol composition further containing a compressed propellant.

In addition, the cosmetic composition of the present invention, in addition to rhubarb and / or rhubarb extract and vitamin C, fatty substances, organic solvents, solubilizers, thickening and gelling agents, emollients, antioxidants, suspending agents, stabilizers, foaming agents (foaming agents) , Fragrances, surfactants, water, ionic or nonionic emulsifiers, fillers, metal ion sequestrants and chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles Or adjuvants conventionally used in the cosmetic or dermatological arts. In addition, the above components may be introduced in an amount generally used in the dermatology field.

Examples of the product to which the cosmetic composition of the present invention can be added include a lotion, an essence, a lotion, a cream, a pack, a gel, an ointment, a patch, a spray, and the like.

The cosmetic composition of the present invention may be prepared in any formulation commonly prepared in the art, and specific formulations thereof include skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisturizing lotion, nutrition lotion, massage cream Formula such as nourishing cream, moisturizing cream, hand cream, essence, nourishing essence, pack, soap, shampoo, cleansing foam, cleansing lotion, cleansing cream, body lotion, body cleanser, latex, press powder, loose powder, eye shadow It may include.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it is to those skilled in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. Will be self-evident. Compounding amount is shown by weight%.

Experimental Example 1: Antioxidant Activity Test

In order to test the antioxidative effect on duct extract, Angelica extract, and vitamin C, it was generally measured using DPPH solution, which is a method of measuring antioxidant activity.

100 μl of pontoon extract, Angelica extract, vitamin C 200mg / ml and DPPH solution, an antioxidant measurement solution, were mixed for 30 minutes at 37 ° C., and then absorbance was measured at 517 nm using an ELISA reader.

Antioxidant activity (%) was based on Equation 1, the results are shown in Table 1 below.

% Antioxidant activity = (1-treated absorbance / untreated absorbance) × 100

Sample Name Antioxidant activity (%) Vitamin c 64.8% Duct extract 59.7% Angelica Extract 55.1% Vitamin C + Falcon Extract 79.2% Vitamin C + Angelica Extract 76.5%

As can be seen from the above results, the duct extract and the Angelica extract used in the present invention showed high antioxidant activity, and when used together with vitamin C, it can be seen that the antioxidant activity was better.

Examples and Comparative Examples

To the cosmetic composition having a composition ratio of Table 2 below, the Examples and Comparative Examples containing the duct extract and the Angelica extract stabilizing the vitamin C was prepared in the following composition.

ingredient Example 1 Example 2 Example 3 Comparative Example 1 Content (% by weight) Content (% by weight) Content (% by weight) Content (% by weight) Duct extract 1.0 2.0 - - Angelica Extract 1.0 - 2.0 - Vitamin C 3.0 3.0 3.0 3.0 A Cetostearyl alcohol 2.0 2.0 2.0 2.0 Glyceryl Stearate 1.5 1.5 1.5 1.5 Mikey-Crystalline 0.7 0.7 0.7 0.7 Squalane 5.0 5.0 5.0 5.0 Liquid paraffin 3.0 3.0 3.0 3.0 Trioctanoine 5.0 5.0 5.0 5.0 Polysorbate 1.2 1.2 1.2 1.2 Sorbitan stearate 0.5 0.5 0.5 0.5 Tocopherol Acetate 0.2 0.2 0.2 0.2 Micromethicone 3.0 3.0 3.0 3.0 BHT 0.05 0.05 0.05 0.05 B glycerin 4.0 4.0 4.0 4.0 1,3-butylene glycol 2.0 2.0 2.0 2.0 EDTA-2Na 0.05 0.05 0.05 0.05 Purified water To 100 To 100 To 100 To 100 Incense, preservative Quantity Quantity Quantity Quantity

Experimental Example 2: Vitamin C Stabilization Test

In Examples 1 to 3 and Comparative Examples of Table 2, the vitamin C stabilization test was performed to determine the effect of the duct extract and Angelica extract on the vitamin C stabilization.

Vitamin C is very unstable in heat, light, oxygen, etc., causing discoloration and odor in the air, causing problems of skin safety and formulation stability, and the potency may be drastically reduced.

In order to determine the degree of stabilization of vitamin C in Examples 1 and 2 and Comparative Examples shown in Table 2 was confirmed the degree of discoloration and titers using HPLC.

Experimental Example 2-1: Measurement of discoloration degree

 The maximum absorbance at 420nm was measured by UV-VIS spectrophotometer to measure the degree of discoloration. It contained 3% of vitamin C and was stored for each temperature in the state of blocking the light and air, the degree of discoloration was measured based on the initial value and the method is shown in Equation 2. It was measured at intervals of 15 days for 60 days, and the results are shown in Table 3 below.

% Discoloration = [(absorbance after elapsed-initial absorbance) / initial absorbance] * 100

division Storage temperature Initial value Day 15 Elapsed 30 days 45 days pass Elapsed 60 days (%) Discoloration degree (%) Discoloration degree (%) Discoloration degree (%) Discoloration degree (%) Example 1 Room temperature 0.0 1.1 1.4 2.0 2.1 35 ℃ 0.0 2.9 3.3 3.7 3.9 45 ℃ 0.0 3.5 3.9 4.1 4.3 Example 2 Room temperature 0.0 1.2 1.4 2.1 2.2 35 ℃ 0.0 3.1 3.5 3.8 3.9 45 ℃ 0.0 3.9 4.1 4.3 4.4 Example 3 Room temperature 0.0 1.2 1.4 1.7 2.0 35 ℃ 0.0 3.0 3.2 3.6 3.8 45 ℃ 0.0 3.7 3.9 4.2 4.4 Comparative example Room temperature 0.0 5.3 7.9 8.4 10.9 35 ℃ 0.0 7.9 9.7 11.7 14.4 45 ℃ 0.0 8.4 10.1 13.5 17.4

In the comparative example without using the vegetable antioxidant as shown in the results of Table 3, the vitamin C is unstable to heat, so the degree of discoloration is large, but vitamins of Examples 1 to 3 containing at least one duct extract and Angelica extract It can be seen that it is effective in suppressing discoloration of C.

Experimental Example 2-2: determination of titer of vitamin C

In the present invention, Comparative Examples and Examples 1 to 3 contain 3% of vitamin C. In order to determine the effect of the two extracts used in the present invention on the maintenance of the titer of vitamin C, the content of vitamin C was measured using HPLC. As in Experiment 2-1 was stored according to the temperature in the state of blocking light and air, which was measured at intervals of 15 days for 60 days based on the initial value, the results are shown in Table 4 below.

division Storage temperature Initial value Day 15 Elapsed 30 days 45 days pass Elapsed 60 days (%) Survival rate (%) Survival rate (%) Survival rate (%) Survival rate (%) Example 1 Room temperature 100 99.68 98.30 97.84 96.10 35 ℃ 100 97.23 98.12 97.01 95.42 45 ℃ 100 96.87 97.52 96.08 94.01 Example 2 Room temperature 100 99.44 98.09 96.76 95.02 35 ℃ 100 98.81 97.34 94.67 92.16 45 ℃ 100 98.00 96.12 93.03 91.76 Example 3 Room temperature 100 99.03 98.03 96.35 94.79 35 ℃ 100 98.72 96.99 94.03 92.34 45 ℃ 100 98.43 95.78 91.24 91.56 Comparative example Room temperature 100 97.12 96.30 90.13 86.74 35 ℃ 100 95.21 90.07 85.17 81.09 45 ℃ 100 92.01 88.13 82.76 75.13

As in the results of Table 4, Yeongyo extract and Angelica extract play an excellent role in stabilizing by maintaining the titer of vitamin C. In Examples 1 to 3, the residual ratio of vitamin C was maintained at 90% or more after 60 days when compared with the comparative example.

As a result, the two extracts used in the present invention were found to have excellent antioxidant power as a vegetable antioxidant and excellent ability to stabilize vitamin C.

Hereinafter, based on the results of the above experimental example, the weight ratio of duct extract and donkey extract is contained in a ratio of 1: 1 in duct extract and donkey extract to present a vitamin C stabilized cosmetic composition. However, the composition of the present invention is not intended to be limited to the following formulation examples.

Formulation Example 1: Softener (Skin Lotion)

As shown in the following table, the softening lotion was prepared according to a conventional method.

Compounding ingredients Content (% by weight) Yeongyo and Angelica Extract 2.0 Vitamin C 0.5 1.3-butylene glycol 6.0 glycerin 4.0 Oleyl alcohol 0.1 Polysorbate 20 0.5 ethanol 15.0 Benzophenone-9 0.05 Incense, preservative a very small amount Purified water to 100

Formulation Example 2. Nutrients (Milk Lotion)

Nutrients were prepared according to a conventional method as shown in the table below.

Compounding ingredients Content (% by weight) Yeongyo and Angelica Extract 2.0 Vitamin C 3.0 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 1.2 Tocophenyl Acetate 3.0 Liquid paraffin 5.0 Squalane 3.0 Macadamia Nut Oil 2.0 Polysorbate 60 1.5 Sorbitan sesquioleate 1.0 Carboxyvinyl Polymer 1.0 Bietchiti 0.01 EDTA-2Na 0.01 Incense, preservative a very small amount Purified water to 100

Formulation Example 3. Nutrition Cream

Nutritious cream was prepared according to a conventional method as shown in the following table.

Compounding ingredients Content (% by weight) Yeongyo and Angelica Extract 2.0 Vitamin C 2.0 Cetostearyl alcohol 2.0 Glyceryl Stearate 1.5 Trioctanoine 5.0 Polysorbate 60 1.2 Sorbitan stearate 0.5 Squalane 5.0 Floating paraffin 3.0 Cyclomethicone 3.0 BH 0.05 Delta-tocopherol 0.2 Concentrated glycerin 4.0 1,3-butylene glycol 2.0 Santa sword 0.1 EDTA-2Na 0.05 Incense, preservative a very small amount Purified water to 100

Formulation Example 4 Massage Cream

Massage cream was prepared according to a conventional method as shown in the table below.

Compounding ingredients Content (% by weight) Yeongyo and Angelica Extract 2.0 Vitamin C 0.5 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 0.5 Beeswax 2.0 Tocopheryl acetate 0.1 Polysorbate 60 3.0 Sorbitan sesquioleate 2.5 Cetearyl Alcohol 2.0 Liquid paraffin 30.0 Carboxy Vinyl Polymer 0.5 Incense, preservative a very small amount Purified water to 100

Formulation Example 5 Pack

Packs were prepared according to conventional methods as shown in the table below.

Compounding ingredients Content (% by weight) Yeongyo and Angelica Extract 2.0 Vitamin C 1.0 Propylene glycol 2.0 glycerin 4.0 Carboxyvinyl Polymer 0.3 ethanol 7.0 Fiji-40 Hydrogenated Castor Oil 0.8 Triethanolamine 0.3 Bietchiti 0.01 EDTA-2Na 0.01 Incense, preservative a very small amount Purified water to 100

Claims (6)

Cosmetic composition stabilized vitamin C by containing one extract and vitamin C selected from Yeongyo extract, Angelica extract or Yeongyo and Angelica extract as an active ingredient. The cosmetic composition of claim 1, wherein the extract is contained in an amount of 0.01 to 10.0 wt% based on the total weight of the cosmetic composition. The cosmetic composition of claim 2, wherein the soft and soft extracts of the soft and soft extracts are stabilized in a weight ratio of soft and green extracts. The cosmetic composition of claim 1, wherein the vitamin C is contained in an amount of 0.001 to 20.0 wt% based on the total weight of the cosmetic composition. According to claim 1, wherein the extract has an antioxidant power, cosmetic composition, characterized in that to stabilize the discoloration, odor, titer of vitamin C. The method of claim 1, wherein the cosmetic composition is stabilized vitamin C, characterized in that formed in any one type selected from the group consisting of lotion, essence, lotion, cream, pack, gel, ointment, patch, or spraying agent. Cosmetic composition.