JPH1045528A - Antioxidant - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a natural antioxidant containing an extract from a specific plant as active ingredient, exhibiting its efficacy in preventing skin lipids from oxidation, skin damage due to oxidation, and also in preventing the skin from aging through its formulation in cosmetics, etc. SOLUTION: This antioxidant contains an extract from a plant belonging to the family Caesalpinia sepiaria (pref. Caesalpinia sappan, Caesalpinia echinata, Caesalpinia spinosa). For the extract, any part of the plant such as flowers, fruits, leaves, twigs, core materials, barks or roots, may be used. The amount of the antioxidant to be formulated in e.g. a cosmetic is normally 0.00001-5.0 (pref. 0.00005-2.0)wt.% on a dry basis. Appropriate use of this antioxidant affords cosmetics, etc., excellent in safety and stable to oxidation.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an antioxidant, particularly to a cosmetic (including quasi-drugs; the same applies hereinafter) and the like, which are used to prevent oxidation of skin lipid components, oxidative damage to skin, and skin aging. Also, it relates to an antioxidant exhibiting its effectiveness.

[0002]

2. Description of the Related Art Conventionally, various antioxidants have been added to cosmetics for the purpose of improving shelf life, but BHA (butylhydroxyanisole), BHT (butylhydroxytoluene), etc. The use of these synthetic antioxidants is being reexamined, especially from the viewpoint of safety. On the other hand, since the skin is the outermost layer of the living body, it is subjected to various stresses from the outside due to ultraviolet rays, free radicals, and the like, and various oxidative damages such as these lead to peroxidation of sebum and aging of the skin. Conventionally, attempts have been made to prevent oxidative damage by blending an antioxidant with an external preparation for skin. From the above background, the demand for vitamin E as a natural antioxidant is increasing, but its antioxidant effect is weak, and there are problems with the source, effect, solubility, price, etc. . Therefore, the development of new antioxidants is strongly required. An object of the present invention is to provide an excellent antioxidant which has a strong antioxidant power as a natural product and has no problem in safety.

[0003]

Means for Solving the Problems In view of the above circumstances, the present inventors have considered that crude drugs that have been used for human bodies for a long time and are considered to have few safety problems are effective as natural antioxidants. As a result of investigation, it was surprisingly found that an extract of the plant of the genus Jacobs genus has an antioxidant power equal to or higher than that of vitamin E, and the present invention has been completed.

[0004] That is, the present invention is an antioxidant characterized by comprising an extract of a plant of the genus Japonica as an active ingredient.

Hereinafter, the configuration of the present invention will be described in detail. Regarding Sujo (also referred to as Secang) and cod among the plants belonging to the genus Jacobs, the present applicant has previously found that these extracts have tyrosinase inhibitory action and melanin production inhibitory action. Have been found (Japanese Patent Laid-Open No. 12550/1996, Japanese Patent Application No.
-200467). This time, the present applicant has newly found that an extract of the plant of the genus Jaketibara has an antioxidant effect.

Examples of the plant belonging to the genus Jackweed in the present invention include Susou (Caesalpinia sappan), Brasilian (scientific name: Caesalpinia echinata), and Cod (scientific name: Caesal).
piniaspinosa), Jacuzzi rose (Caesalpinia japoni)
ca Sieb), White-faced Tuna (Caesalpinia decapet)
ala), Red-necked rose (Caesalpinia gilliesi)
i), Nanden Kazura (Caesalpinia nuga), and Ginkgo (Caesalpinia pulcherrima). Among them, particularly preferred one is suhou (Caesalpinia sappa).
n), Brazil I (scientific name: Caesalpinia echinata) and cod (scientific name: Caesalpinia spinosa). In addition, the extract of the present invention includes flowers of the genus Plutella,
Any site such as a fruit, a leaf, a branch, a heartwood, a bark, and a root may be used.

The extract of the plant of the genus Jaketibara, which is the antioxidant of the present invention, is prepared by dissolving the plant of the genus Jaketibara in a solvent, for example, a polar solvent such as water, lower alcohol, hydrated lower alcohol, propylene glycol, 1,3-butylene glycol, and butanol. Alternatively, an extract obtained by extracting with chloroform, dichloroethane, carbon tetrachloride, ethyl acetate, ether, or the like or an organic solvent of a mixture thereof or using an extract as it is or concentrated, or using an extract by an adsorption method, for example, ion exchange resin, Using a porous polymer (for example, Amberlite XAD-
After adsorption by the column of 2), elution with methanol or ethanol and concentration of the extract can also be used. Further, a partitioning method, for example, an extract extracted with butanol or the like is also used.

[0008] The amount of the extract of the plant of the genus Jaketibara is generally from 0.00001 to 5.0% by weight (as dry matter), and preferably, by adding an amount of 0.00005 to 2.0% by weight, Has an excellent antioxidant effect.

Cosmetics are preferred as the object to be incorporated as an antioxidant. When added to various cosmetics requiring an antioxidant action, for example, creams, lotions, emulsions, hair oils, shampoos, rinses, soaps, etc., excellent antioxidant power is obtained. Demonstrate. Other additives to be added to such cosmetics include, for example, oils, surfactants, thickeners, neutralizers, preservatives, powder components, pigments, sequestering agents, fragrances, and ultraviolet absorption. Agents, medicinal agents, etc., and are used in appropriate combinations as needed. As a matter of course, the antioxidant of the present invention can be used in combination with other antioxidants such as vitamin E, licorice extract, BHT, BHA, etc. within a range that does not impair the effects of the present invention.

[0010]

Next, for the purpose of explaining the present invention in more detail,
As examples, preparation examples, effect test examples and formulation examples of the antioxidant of the present invention are shown.

1. Preparation of Samples (1) Preparation Example 1 (Subou Ethanol Extract) 20 kg of 60% ethanol was added to 1 kg of the flower and dried fruit of suhou, and the mixture was immersed at room temperature for 10 days for extraction, and the extract was filtered, The ethanol was concentrated to obtain 50 g of the extract as a dry residue.

(2) Preparation Example 2 (Suho chloroform extract) 9 kg of chloroform was added to 1 kg of dried spho leaves.
The mixture was refluxed at 50 ° C. for 8 hours for extraction, the extract was filtered, and then chloroform was concentrated to leave the extract as a dry residue.
0 g was obtained.

(3) Preparation Example 3 (Supo methanol extract) 10 kg of methanol is added to 1 kg of dried xylem xylem, extracted by immersion at room temperature for 10 days, and the extract is filtered and concentrated. 10 g of extract was obtained.

(4) Preparation Example 4 (Brazil Boku Ethanol Extract) 20 kg of 60% ethanol was added to 1 kg of dried flower of Brazil Bak and extracted by immersion at room temperature for 10 days, and the extract was filtered. Then, ethanol was concentrated to obtain 30 g of an extract as a dry residue.

(5) Preparation Example 5 (Chloroform extract from Brazil) 9 kg of chloroform was added to 1 kg of dried leaf of Brazil mexica, and the mixture was refluxed at 50 ° C. for 8 hours for extraction, and the extract was filtered, followed by chloroform. The extract was concentrated to obtain 47 g of an extract as a dry residue.

(6) Preparation Example 6 (Brazilian Boku Methanol Extract) 10 kg of methanol is added to 1 kg of dried xylem from Brazil Boku
g, and the mixture was immersed at room temperature for 10 days for extraction, the extract was filtered, and then concentrated to obtain 25 g of extract.

(7) Preparation Example 7 (Cod Methanol Extract) 20 kg of methanol is added to 1 kg of dried cod seeds and pods
In addition, the mixture was immersed at room temperature for 10 days for extraction, the extract was filtered, and then methanol was concentrated to obtain 60 g of the extract as a dry residue.

(8) Preparation Example 8 (Cod chloroform extract) 15 kg of chloroform is added to 1 kg of dried cod leaves,
The mixture was extracted by refluxing at 50 ° C. for 8 hours, and the extract was filtered.
0 g was obtained.

(9) Preparation Example 9 (Purified Cod Ethanol Extract) 10 kg of ethanol was added to 1 kg of dried whole cod plant.
After extraction by immersion at room temperature for 10 days, the extract was filtered, the filtrate was applied to an Amberlite XAD2 column, the column was washed with water, eluted with ethanol, and the eluate was concentrated to obtain 18 g of an extract.

2. Test method and test results 1.0 mg methyl linoleate (manufactured by Tokyo Kasei Kogyo Co., Ltd.) / Ml Acetone solution of 1.0 ml prepared in Preparation Example 3 of the extract of the quince xylem, and prepared in Preparation Example 6 The xylem extract and the cod extract prepared in Preparation Example 7 were each added in an amount of 0.001 mg or 0.01 mg, dispensed into a test tube with a screw cap, and dried to dryness.
For 4 hours, and the non-oxidized group was stored at 4 ° C. After the treatment, a non-aqueous TBA reagent (0.12% 2-thiobarbituric acid (T
BA) /0.50% triethylamine (TEA) / acetic acid) (3.0 ml) was added, and the mixture was reacted at 95 ° C for 1 hour.
Immediately after the reaction, the mixture was cooled with water, the absorbance at 532 nm was measured, and the oxidation inhibition rate was calculated.

[0021]

[Equation 1] Oxidation inhibition rate (%) = [1- (As50-As4) /
(Ac50-Ac4)] × 100

Ac50: absorbance of control at 50 ° C. Ac4: absorbance of control stored at 4 ° C. As50: Absorbance of sample heated at 50 ° C. As4: absorbance of the sample stored at 4 ° C.

As controls, vitamin E (DL-α-tocopherol, manufactured by Tokyo Kasei Kogyo Co., Ltd.) and BHT (Wako Pure Chemical Industries, Ltd.) were used instead of the stalk xylem extract, Brazilian xylem extract and cod extract. The same operation was carried out for the one to which (made by the company) was added. Table 1 shows the results.

[0024]

[Table 1] 試 料 Sample No. Antioxidant compounding amount (mg) Oxidation Suppression rate (%) ────────────────────────────────── 1 Sugar xylem extract (Preparation Example 3) 0.001 92.3 2 Sugar xylem extract (Preparation example 3) 0.01 97.6 3 Brazilian xylem xylem extract (Preparation example 6) 0.001 75.3 4 Brazilian xylem xylem extract (Preparation example 6) 0.01 97.5 5 Cod extract (Preparation example) 7) 0.001 60.5 6 Cod extract (Preparation Example 7) 0.01 100.0 ────────────────────────────────── 7 Vitamin E 0.001 42.4 8 Vitamin E 0.01 82.4 9 BHT 0.001 97.3 ──────────────────────────────────

As shown in Table 1, the xylem xylem extract, Brazilian xylem xylem extract and cod extract show an antioxidant effect superior to vitamin E, and further, the xylem xylem extract and the Brazilian xylem extract Also, if the concentration of the cod extract is increased, it shows a remarkable antioxidant effect equivalent to that of BHT.

Example 1 Lotion (1) Suho extract (Preparation Example 1) 0.1% by weight (2) Tocopherol acetate 0.01 (3) Glycerin 4.0 (4) 1,3-butylene glycol 4.0 ( 5) Ethanol 8.0 (6) Polyoxyethylene (60) hydrogenated castor oil 0.5 (7) Methyl paraben 0.2 (8) Citric acid 0.05 (9) Sodium citrate 0.1 (10) Fragrance 0 .05 (11) Purified water residue (Preparation method) Citric acid, sodium citrate, glycerin and 1,3-butylene glycol are dissolved in purified water. Separately, suho extract, polyoxyethylene (60) hydrogenated castor oil, tocopherol acetate, fragrance, and methylparaben are dissolved in ethanol, and this is added to the above-mentioned purified aqueous solution and solubilized.
Filtration gave a lotion.

Example 2 Cream (1) 3.5% by weight cetostearyl alcohol (2) Squalane 40.0 (3) Beeswax 3.0 (4) Reduced lanolin 5.0 (5) Ethylparaben 0.3 (6) ) Polyoxyethylene (20) sorbitan monopalmitate 2.0 (7) Monoglyceride stearate 2.0 (8) Sodium N-stearoyl glutamate 0.5 (9) 2-Hydroxy-4-methoxybenzophenone 0.5 ( 10) Octyl methoxycinnamate 1.0 (11) Retinol acetate 2.0 (12) Evening primrose oil 0.05 (13) Perfume 0.03 (14) Suhou extract (Preparation example 2) 0.01 (15) Polyethylene glycol 1500 5.0 (16) Purified water residue (Production method) cetostearyl alcohol, squalane, beeswax, reduced lanolin, ethylparaben, polyoxyethylene (20) sorbita Monopalmitic acid ester, stearic acid monoglyceride, sodium N-stearoylglutamate, 2-hydroxy-4-methoxybenzophenone, octyl methoxycinnamate, retinol acetate,
Evening primrose oil, fragrance, and spinach extract are dissolved by heating (oil phase),
Dissolve polyethylene glycol 1500 in purified water and add 7
Keep at 0 ° C. (aqueous phase), add oil phase to aqueous phase with stirring. After homogenizing the emulsion to make the emulsified particles fine, the mixture was rapidly cooled while stirring to obtain a cream.

Example 3 Emulsion (1) 2-ethylhexyl paradimethylaminobenzoate 0.1% by weight (2) Mono-2-ethylhexyl diparamethoxycinnamate 0.2 (3) Stearic acid 1.5 ( 4) Cetyl alcohol 0.5 (5) Beeswax 2.0 (6) Polyoxyethylene (10) monooleate 2.0 (7) L-arginine 0.3 (8) L-sodium glutamate 0.02 ( 9) PCA-Na 0.05 (10) Suho Extract (Preparation Example 3) 0.05 (11) Glycerin 3.0 (12) Ethanol 3.0 (13) Ethylparaben 0.3 (14) Perfume 0.03 ( 15) Carboxyvinyl polymer 0.12 (16) Purified water residue (Preparation method) Add L-arginine, L-sodium glutamate, PCA-Na, glycerin, ethanol, and carboxyvinyl polymer to purified water, dissolve by heating, and heat to 70 ° C. Protection (Aqueous phase). The other components, such as the shouhou extract, are mixed, dissolved by heating, and kept at 70 ° C. (oil phase). Preliminary emulsification is performed by adding the oil phase to the water phase, and the mixture is uniformly emulsified with a homomixer. Then, it was rapidly cooled with stirring to obtain an emulsion.

Example 4 Foam Mask (1) Spout Extract (Preparation Example 3) 0.01% by Weight (2) Stearic Acid 1.0 (3) Behenic Acid 1.0 (4) Self-emulsifying Glycerin Monostearate 1. 5 (5) Polyoxyethylene monostearate (5) Glycerin 2.5 (6) Bacyl alcohol 1.5 (7) Fragrance 0.05 (8) Glycerin 5.0 (9) 1,3-butylene glycol 5. 0 (10) Polyethylene glycol 1500 3.0 (11) Methyl paraben 0.1 (12) Potassium hydroxide 0.15 (13) Purified water residue (14) Liquefied petroleum gas 6.0 (15) Dimethyl ether 2.0 (Production method ) Supo extract, glycerin, 1,3-
Butylene glycol, polyethylene glycol 150
Add 0, methylparaben, and potassium hydroxide, and dissolve by heating at 70 ° C. A mixture obtained by uniformly mixing them is filled in a container. Finally, liquefied gas and dimethyl ether were added as a propellant to obtain a foam mask.

Example 5 Ointment (1) Suho extract (Preparation Example 1) 0.1% by weight (2) Octyl paradimethylaminobenzoate 4.0 (3) Butylmethoxybenzoylmethane 0.5 (4) Tocopherol acetate 0. 5 (5) Retinol palmitate 1.0 (6) Stearyl alcohol 18.0 (7) Mokuro 20.0 (8) Polyoxyethylene (10) monooleate 0.25 (9) Glycerin monostearate 0 .3 (10) Vaseline 32.0 (11) Purified water Residual (production method) The sprouts extract and other components are mixed and dissolved at 70 ° C (oil phase). Add the oil phase to the water phase maintained at 70 ° C,
The mixture was uniformly emulsified with a homomixer and then cooled to obtain an ointment.

Example 6 Toner Lotion (1) Brazilian Box Extract (Preparation Example 4) 0.1% by Weight (2) Tocopherol Acetate 0.01 (3) Glycerin 4.0 (4) 1,3-Butylene Glycol 4. 0 (5) Ethanol 8.0 (6) Polyoxyethylene (60) Hydrogenated castor oil 0.5 (7) Methylparaben 0.2 (8) Citric acid 0.05 (9) Sodium citrate 0.1 (10) Perfume 0.05 (11) Purified water residue (Preparation method) Citric acid, sodium citrate, glycerin and 1,3-butylene glycol are dissolved in purified water. Separately, Brazilian myx extract, polyoxyethylene (6
0) Hardened castor oil, tocopherol acetate, fragrance, and methyl paraben were dissolved, added to the above purified aqueous solution to solubilize, and filtered to obtain a lotion.

Example 7 Cream (1) Cetostearyl alcohol 3.5% by weight (2) Squalane 40.0 (3) Beeswax 3.0 (4) Reduced lanolin 5.0 (5) Ethylparaben 0.3 (6 ) Polyoxyethylene (20) sorbitan monopalmitate 2.0 (7) stearic acid monoglyceride 2.0 (8) sodium N-stearoyl glutamate 0.5 (9) 2-hydroxy-4-methoxybenzophenone 0.5 ( 10) Octyl methoxycinnamate 1.0 (11) Retinol acetate 2.0 (12) Evening primrose oil 0.05 (13) Fragrance 0.03 (14) Brazilian box extract (Preparation example 5) 0.01 (15) Polyethylene glycol 1500 5.0 (16) Purified water Residual (production method) cetostearyl alcohol, squalane, beeswax, reduced lanolin, ethylparaben, polyoxyethylene (20) sodium Rubitan monopalmitate, stearic monoglyceride, sodium N-stearoylglutamate, 2-hydroxy-4-methoxybenzophenone, octyl methoxycinnamate, retinol acetate,
Evening primrose oil, fragrance, and Brazilian extract are heated and dissolved (oil phase), polyethylene glycol 1500 is dissolved in purified water, kept at 70 ° C. (aqueous phase), and the oil phase is added to the aqueous phase with stirring. The mixture was treated with a homomixer to make the emulsified particles finer, and then rapidly cooled with stirring to obtain a cream.

Example 8 Emulsion (1) 2-Ethylhexyl paradimethylaminobenzoate 0.1% by weight (2) Mono-2-ethylhexyl diparamethoxycinnamate 0.2 (3) Stearic acid 1.5 ( 4) Cetyl alcohol 0.5 (5) Beeswax 2.0 (6) Polyoxyethylene (10) Monooleate 2.0 (7) L-arginine 0.3 (8) L-sodium glutamate 0.02 ( 9) PCA-Na 0.05 (10) Brazilian Box extract (Preparation Example 6) 0.05 (11) Glycerin 3.0 (12) Ethanol 3.0 (13) Ethylparaben 0.3 (14) Perfume 0. 03 (15) Carboxyvinyl polymer 0.12 (16) Purified water residue (Preparation method) L-arginine, L-sodium glutamate, PCA-Na, glycerin, ethanol, carboxyvinyl polymer were added to purified water, and dissolved by heating. Keep at ° C (aqueous phase). Brazilian Boku extract and other ingredients are mixed, heated and melted and kept at 70 ° C (oil phase). Preliminary emulsification is performed by adding the oil phase to the water phase, and the mixture is uniformly emulsified with a homomixer. Thereafter, the mixture was rapidly cooled while stirring to obtain an emulsion.

Example 9 Foam Mask (1) Brazilian Box Extract (Preparation Example 6) 0.01% by weight (2) Stearic acid 1.0 (3) Behenic acid 1.0 (4) Self-emulsifying glyceryl monostearate 1.5 (5) Polyoxyethylene monostearate (5) glycerin 2.5 (6) Bacyl alcohol 1.5 (7) Fragrance 0.05 (8) Glycerin 5.0 (9) 1,3-butylene glycol 5.0 (10) Polyethylene glycol 1500 3.0 (11) Methylparaben 0.1 (12) Potassium hydroxide 0.15 (13) Purified water Residual (14) Liquefied petroleum gas 6.0 (15) Dimethyl ether 2.0 (Manufacturing method) Brazilian box extract, glycerin,
Add 1,3-butylene glycol, polyethylene glycol 1500, methyl paraben, potassium hydroxide,
Dissolve by heating to 0 ° C. A mixture obtained by uniformly mixing them is filled in a container. Finally, liquefied gas and dimethyl ether were added as a propellant to obtain a foam mask.

Example 10 Ointment (1) Brazilian box extract (Preparation Example 4) 0.1% by weight (2) Octyl paradimethylaminobenzoate 4.0 (3) Butylmethoxybenzoylmethane 0.5 (4) Tocopherol acetate 0.5 (5) Retinol palmitate 1.0 (6) Stearyl alcohol 18.0 (7) Mrow 20.0 (8) Polyoxyethylene (10) monooleate 0.25 (9) Glycerin monostearate Ester 0.3 (10) Vaseline 32.0 (11) Purified water Residue (manufacturing method) Brazilian box extract and other components are mixed and dissolved at 70 ° C (oil phase). The oil phase was added to the aqueous phase kept at 70 ° C., the mixture was uniformly emulsified with a homomixer, and then cooled to obtain an ointment.

Example 11 Lotion (1) Cod Extract (Preparation Example 7) 0.1% by Weight (2) Tocopherol Acetate 0.01 (3) Glycerin 4.0 (4) 1,3-Butylene Glycol 4.0 ( 5) Ethanol 8.0 (6) Polyoxyethylene (60) Hydrogenated castor oil 0.5 (7) Methylparaben 0.2 (8) Citric acid 0.05 (9) Sodium citrate 0.1 (10) Perfume 0 .05 (11) Purified water Residual (manufacturing method) Citric acid, sodium citrate, glycerin, and 1,3-butylene glycol are dissolved in purified water. Separately, cod extract, polyoxyethylene (60) hydrogenated castor oil, tocopherol acetate, fragrance, and methyl paraben were dissolved in ethanol, and the resulting solution was added to the above-mentioned purified aqueous solution to solubilize and filtered to obtain a lotion.

Example 12 Cream (1) cetostearyl alcohol 3.5% by weight (2) squalane 40.0 (3) beeswax 3.0 (4) reduced lanolin 5.0 (5) ethyl paraben 0.3 (6 ) Polyoxyethylene (20) sorbitan monopalmitic acid ester 2.0 (7) stearic acid monoglyceride 2.0 (8) sodium N-stearoylglutamate 0.5 (9) 2-hydroxy-4-methoxybenzophenone 0.5 ( 10) Octyl methoxycinnamate 1.0 (11) Retinol acetate 2.0 (12) Evening primrose oil 0.05 (13) Perfume 0.03 (14) Cod extract (Preparation Example 8) 0.01 (15) Polyethylene glycol 1500 5.0 (16) Purified water Residue (production method) cetostearyl alcohol, squalane, beeswax, reduced lanolin, ethylparaben, polyoxyethylene (20) sorbita Monopalmitic acid ester, stearic acid monoglyceride, N-stearoyl sodium glutamate, 2-hydroxy-4-methoxybenzophenone, octyl methoxycinnamate, retinol acetate,
The evening primrose oil, flavor, and cod extract are dissolved by heating (oil phase), and polyethylene glycol 1500 is dissolved in purified water.
Keep at 0 ° C. (aqueous phase), add oil phase to aqueous phase with stirring. After homogenizing the emulsion to make the emulsified particles fine, the mixture was rapidly cooled while stirring to obtain a cream.

Example 13 Emulsion (1) 2-ethylhexyl paradimethylaminobenzoate 0.1% by weight (2) mono-2-ethylhexyl diparamethoxycinnamate 0.2 (3) Stearic acid 1.5 ( 4) Cetyl alcohol 0.5 (5) Beeswax 2.0 (6) Polyoxyethylene (10) monooleate 2.0 (7) L-arginine 0.3 (8) L-sodium glutamate 0.02 ( 9) PCA-Na 0.05 (10) Cod extract (Preparation Example 9) 0.05 (11) Glycerin 3.0 (12) Ethanol 3.0 (13) Ethylparaben 0.3 (14) Fragrance 0.03 ( 15) Carboxyvinyl polymer 0.12 (16) Purified water residue (Preparation method) Add L-arginine, L-sodium glutamate, PCA-Na, glycerin, ethanol, and carboxyvinyl polymer to purified water, dissolve by heating, and heat to 70 ° C. Security (Aqueous phase). The cod extract and other components are mixed, dissolved by heating and kept at 70 ° C. (oil phase). Preliminary emulsification is performed by adding the oil phase to the water phase, and the mixture is uniformly emulsified with a homomixer. Then, it was rapidly cooled with stirring to obtain an emulsion.

Example 14 Foam Mask (1) Cod Extract (Preparation Example 9) 0.01% by weight (2) Stearic acid 1.0 (3) Behenic acid 1.0 (4) Self-emulsifying glyceryl monostearate 5 (5) Polyoxyethylene monostearate (5) Glycerin 2.5 (6) Batyl alcohol 1.5 (7) Perfume 0.05 (8) Glycerin 5.0 (9) 1,3-Butylene glycol 5. 0 (10) Polyethylene glycol 1500 3.0 (11) Methylparaben 0.1 (12) Potassium hydroxide 0.15 (13) Purified water Residual (14) Liquefied petroleum gas 6.0 (15) Dimethyl ether 2.0 (Production method ) Cod extract, glycerin, 1,3-butylene glycol, polyethylene glycol 1500 in purified water,
Methyl paraben and potassium hydroxide are added, and the mixture is heated and dissolved at 70 ° C. A mixture obtained by uniformly mixing them is filled in a container. Finally, liquefied gas and dimethyl ether were added as a propellant to obtain a foam mask.

Example 15 Ointment (1) Cod extract (Preparation Example 7) 0.1% by weight (2) Octyl paradimethylaminobenzoate 4.0 (3) Butylmethoxybenzoylmethane 0.5 (4) Tocopherol acetate 0. 5 (5) Retinol palmitate 1.0 (6) Stearyl alcohol 18.0 (7) Mrow 20.0 (8) Polyoxyethylene (10) monooleate 0.25 (9) Glycerin monostearate 0 .3 (10) Vaseline 32.0 (11) Purified water Residual (manufacturing method) Cod extract and other components are mixed and dissolved at 70 ° C (oil phase). The oil phase was added to the aqueous phase kept at 70 ° C., the mixture was uniformly emulsified with a homomixer, and then cooled to obtain an ointment.

[0041]

As described above, by appropriately using the antioxidant of the present invention, it is possible to produce cosmetics having excellent safety and being stable against oxidation. In addition, when incorporated into cosmetics, it is effective in preventing oxidation of skin lipid components, oxidative damage to skin, and skin aging, and can protect the skin.

Claims (6)

[Claims] 1. An antioxidant, which comprises an extract of a genus Plutella as a active ingredient. 2. The plant belonging to the genus Jaketibara is Suhou (scientific name:
The antioxidant according to claim 1, which is Caesalpinia sappan). 3. The antioxidant according to claim 1, wherein the plant of the genus Jacobs is Brasilian (scientific name: Caesalpiniaechinata). 4. The plant belonging to the genus Jaketibara is a cod (scientific name: Ca
esalpinia spinosa). 5. The antioxidant according to any one of claims 1 to 4, wherein the amount of the extract of the plant belonging to the genus Jackwort genus is 0.00001 to 5.0% by weight in terms of dry matter. 6. A cosmetic, which comprises an extract of the genus Jacobs as an active ingredient for antioxidant.