KR102365223B1 - Low irritating cosmetic composition for skin whitening comprising albutin, Polygonum tinctorium leaf and Brassica napus whole plant - Google Patents

Abstract

The present invention relates to a cosmetic composition for hypoallergenic skin whitening containing arbutin, indigo leaf and rapeseed whole plant extract, wherein the cosmetic composition for hypoallergenic skin whitening according to the present invention contains arbutin, a whitening functional ingredient, in a high content. , Indigo leaf extract and rapeseed whole plant extract are included together, so there is an effect of remarkably reducing skin irritation caused by arbutin.

Description

Low irritating cosmetic composition for skin whitening comprising albutin, Polygonum tinctorium leaf and Brassica napus whole plant

The present invention relates to a cosmetic composition for hypoallergenic skin whitening containing arbutin, indigo leaf, and rapeseed whole plant extract.

A person's skin color is determined by the concentration and distribution of melanin inside the skin. Melanin is synthesized in melanocytes in the epidermal layer of the skin. In the melanosome, an organelle within melanocytes, an enzyme called tyrosinase acts on tyrosine, a type of amino acid, to activate DOPA and dopaquinone. ) and then undergoes a non-enzymatic oxidation reaction. When such melanin synthesis occurs in the skin excessively, the skin tone is darkened, and spots, freckles, and the like occur. Therefore, by inhibiting the tyrosinase activity in the skin to inhibit the synthesis of melanin pigment, not only can the skin tone be brightened to realize skin whitening, but also hyperpigmentation of the skin such as spots and freckles caused by UV rays, hormones, and genetic causes It can improve sciatica.

As a substance capable of inhibiting the activity of tyrosinase, various extracts including hydroquinone, ascorbic acid, kojic acid, glutathione, arbutin, and epiphyllum extract have been used, but there is a problem in the safety of the skin and the stability of the cosmetic formulation, In the case of arbutin, there is a problem that side effects that cause skin irritation appear.

The present inventors developed a cosmetic composition that does not cause skin irritation even if it contains a high concentration of whitening functional ingredients . When the extract was used in combination, it was found that skin irritation was significantly reduced, and the present invention was completed.

Registered Patent Publication No. 10-0923141

An object of the present invention is to provide a cosmetic composition for skin whitening hypoallergenic.

In order to achieve the above object,

The present invention is arbutin;

Indigo ( Polygonum tinctorium ) leaf extract; and

Rape ( Brassica napus ) herb extract;

It provides a cosmetic composition for skin whitening hypoallergenic, comprising a.

Although the cosmetic composition for hypoallergenic skin whitening according to the present invention contains a high content of arbutin, which is a whitening functional ingredient, indigo ( Polygonum tinctorium ) leaf extract and rapeseed ( Brassica napus ) extract together with arbutin. It has the effect of significantly reducing irritation.

Hereinafter, the present invention will be described in detail.

The present invention is arbutin;

Indigo ( Polygonum tinctorium ) leaf extract; and

Rape ( Brassica napus ) herb extract;

It provides a cosmetic composition for skin whitening hypoallergenic, comprising a.

Preferably,

based on 5 parts by weight of arbutin;

Indigo ( Polygonum tinctorium ) leaf extract 0.1-5.0 parts by weight;

Rapeseed ( Brassica napus ) 0.1-5.0 parts by weight of a herbal extract;

may include

More preferably,

based on 5 parts by weight of arbutin;

Indigo ( Polygonum tinctorium ) leaf extract 0.5-3.5 parts by weight;

Rape ( Brassica napus ) 0.5-3.5 parts by weight of the herb extract;

may include

Particularly preferably,

based on 5 parts by weight of arbutin;

Indigo ( Polygonum tinctorium ) leaf extract 0.9-2.6 parts by weight;

Rape ( Brassica napus ) 0.9-2.6 parts by weight of whole herb extract;

may include

When used in the range of 0.9-2.6 parts by weight of the indigo leaf extract and 0.9-2.6 parts by weight of the rapeseed whole plant extract based on 5 parts by weight of arbutin, it is possible to minimize skin irritation caused by arbutin.

The extract may be obtained by separating and obtaining the extract using a method known in the art for extraction and separation, and the extract defined in the present invention may be extracted using an appropriate solvent. In this case, as a suitable solvent that can be used to obtain the extract, any solvent acceptable in the art may be used, and water or an organic solvent may be used. For example, purified water, methanol (methanol), ethanol (ethanol), propanol (propanol), isopropanol (isopropanol), alcohols having 1 to 4 carbon atoms including butanol (butanol), acetone (acetone), ether (ether) , benzene (benzene), chloroform (chloroform), ethyl acetate (ethyl acetate), methylene chloride (methylene chloride), hexane (hexane) and various solvents such as cyclohexane (cyclohexane) can be used alone or in combination, but Not limited.

As the extraction method, any one of methods such as hot water extraction, cold extraction, reflux cooling extraction, solvent extraction, steam distillation, ultrasonic extraction, elution, and compression may be selected and used. In addition, the desired extract may be further subjected to a conventional fractionation process, and may be purified using a conventional purification method. There is no limitation on the method for preparing the extract of the present invention, and any known method may be used.

For example, the indigo plant and rapeseed plant extract included in the composition of the present invention may be used as it is, while the primary extract extracted by the solvent extraction method described above is freeze-dried after centrifugation, filtration, and concentration, and stored in a refrigerator, as described above. The tea extract may be prepared in a powder state by additional processes such as vacuum distillation and freeze drying or spray drying. In addition, the primary extract is further purified using various chromatography methods such as silica gel column chromatography, thin layer chromatography, high performance liquid chromatography, and the like. can also get

Accordingly, in the present invention, the extract is a concept including all extracts, fractions and purified substances obtained in each step of extraction, fractionation or purification, and dilutions, concentrates or dried substances thereof.

The cosmetic composition for skin whitening according to the present invention is a cream, nourishing cream, moisture cream, hand cream, massage cream, nourishing lotion, moisture lotion, milk lotion, lotion, astringent, skin lotion, skin softener, skin toner, essence, nutrition Essence, foundation, makeup base, pack, patch, gel, powder, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion, body cleanser, etc. can be prepared and used.

In the cosmetic composition of the present invention, in the composition for external application of each dosage form, other ingredients other than the above-described essential ingredients can be appropriately selected and formulated by those skilled in the art without difficulty depending on the dosage form or purpose of use of other external preparations.

In addition, the cosmetic composition of the present invention may further include a skin protectant that can help the skin, such as a skin moisturizer, a skin softener, and a moisture barrier, in addition to the active ingredients, and a fatty substance, an organic solvent, a solubilizer, and a thickener and gelling agents, emollients, softening agents, antioxidants, suspending agents, stabilizers, pH adjusters, foaming agents, fragrances, surfactants, water, emulsifiers, thickeners, fillers, sequestering and chelating agents, preservatives, vitamins, blocking agents, It may contain adjuvants conventionally used in the field of cosmetology, such as wetting agents, essential oils, fragrances, dyes, pigments, hydrophilic or lipophilic actives, lipid vesicles or any other ingredients commonly used in cosmetics. These adjuvants are introduced in amounts generally used in the field of cosmetology.

As the skin protectant, bouillon extract, Indian frankincense extract, squalane, hydrolyzed collagen, allantoin, capryl hydroxamic acid, hyaluronic acid, rosemary extract, ginseng extract, tocopheryl acetate, D-panthenol, etc. Available.

As the wetting agent, glycerin, butylene glycol, sodium hyaluronate, serine, sorbitol, mannitol, propylene glycol, ethylene glycol, cholesterol, cholesterol ester, and the like can be used.

As an emulsifier, glyceryl stearate, PEG-40 stearate, sorbitan sesquioleate, polysorbate 60, glyceryl stearate/PEG-100 stearate, lipophilic glyceryl stearate, etc. can be used.

As softening agents, caprylic/capric triglyceride, cetearyl alcohol, cyclopentasiloxane, cetylethylhexanoate, cyclohexasiloxane, caprylyl glycol, trioctanoin, cetyloctanoate, stearic acid, Cyclomethicone, shea butter, lanolin, damethicone, etc. can be used.

As a pH adjuster, triethanolamine, citric acid, sodium citrate, malic acid, sodium malate, fumaric acid, sodium fumarate, succinic acid, sodium succinate, sodium hydroxide, sodium monohydrogen phosphate, etc. can be used.

As the thickener, carbomer, hydroxyethyl acrylate/sodium acryloyl dimethyl thiourate copolymer, etc. can be used. As the chelating agent, disodium EDTA can be used. As the solvent, purified water, 1,2-hexane Diol and the like can be used.

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, the following examples only illustrate the present invention, and the content of the present invention is not limited by the following examples.

<Preparation Example 1> page ( Polygonum tinctorium ) Preparation of leaf extract

After pulverizing 100 g of dried indigo leaves, 1 L of 70% ethanol (EtOH) aqueous solution was used, and extraction was performed using a solvent extraction method. In order to increase the extraction efficiency, the extract was prepared by stirring for 48 hours using a stirrer. This was concentrated under reduced pressure at 50° C. or lower and then freeze-dried to obtain a powdery indigo extract.

<Preparation Example 2> Rape ( Brassica napus ) Preparation of herbal extracts

After grinding 100 g of dried rapeseed whole plant, 1 L of 70% ethanol (EtOH) aqueous solution was used, and extraction was performed using a solvent extraction method. In order to increase the extraction efficiency, the extract was prepared by stirring for 48 hours using a stirrer. This was concentrated under reduced pressure at 50° C. or less and then freeze-dried to obtain a powdery rapeseed extract.

<Example 1> Preparation of a cosmetic composition for hypoallergenic skin whitening containing arbutin, indigo leaf and rapeseed extract

A cosmetic composition was prepared using the extracts and arbutin obtained in Preparation Examples 1 and 2 according to the composition of Table 1 below. In Table 1 below, A represents the whitening effect and irritation reducing effect ingredient, and B represents the general cosmetic composition ingredient.

division Ingredients (unit: wt%) Example 1 A arbutin 5.0 indigo leaf extract 1.75 rapeseed extract 1.75 B glycerin 5.0 Butylene Glycol 2.0 Caprylic/Capric Triglycerides 4.0 cetearyl alcohol 2.0 Cyclopentasiloxane 1.5 Cetylethylhexanoate 1.0 Glyceryl Stearate 2.0 PEG-40 Stearate 1.0 C Spices a very small amount Purified water remaining amount Sum 100.00

<Comparative Example 1> Preparation of arbutin-containing cosmetic composition for skin whitening

A cosmetic composition was prepared in the same manner as in Example 1, except that in Example 1, indigo leaf extract and rapeseed extract were not used.

<Comparative Example 2> Preparation of a cosmetic composition for skin whitening containing niacinamide, indigo leaf and rapeseed extract

A cosmetic composition was prepared in the same manner as in Example 1, except that 5% by weight of arbutin, a whitening component, was replaced with 10% by weight of niacinamide in Example 1.

<Comparative Example 3> Preparation of a cosmetic composition for skin whitening containing niacinamide

In Example 1, a cosmetic composition was prepared in the same manner as in Example 1, except that 5 wt% of arbutin, a whitening component, was replaced with 10 wt% of nicinamide, and indigo leaf extract and rapeseed extract were not used. .

<Experimental Example 1> Analysis of whitening effect and skin irritation of cosmetic composition

In order to confirm the whitening effect of the cosmetic composition of Example 1 and Comparative Example 1, artificial pigmentation was induced in 10 randomly selected women aged 19 to 29 with healthy skin, and then the cosmetic composition After letting them use, the skin whitening effect and the presence or absence of skin irritation were evaluated.

Specifically, the skin whitening effect was evaluated before use of the cosmetic composition and at time points 1 week, 2 weeks, 4 weeks, and 6 weeks after using the cosmetic composition. A scale of 1 to 7 was used as the evaluation criteria, 'no pigmentation' was 0 points, 'no or light pigmentation' was 1 point, 'light pigmentation' was 2 points, and 'light or moderate pigmentation' was 3 points. Points, 'moderate pigmentation' were indicated as 4 points, 'moderate or severe pigmentation' as 5 points, 'severe pigmentation' as 6 points, and 'very severe pigmentation' as 7 points. The whitening effect of each cosmetic composition was evaluated by three observers at each time point, and the experimental results are shown in Table 2 below, with the scores evaluated by the three observers as the average value. The presence or absence of skin irritation was evaluated by (number of persons who showed irritation)/(total number of test subjects).

division 0 weeks 1 week 2 weeks 4 weeks 6 weeks skin irritation Example 1 6.6 6.0 5.5 5.1 4.2 0/10 Comparative Example 1 6.6 6.1 5.6 5.1 4.3 7/10

As shown in Table 2, no significant difference was observed in the skin whitening efficacy in Example 1 and Comparative Example 1, but a significant difference was observed in the evaluation results of the presence or absence of skin irritation.

<Experimental Example 2> Analysis of skin irritation according to active ingredients

In order to confirm the presence or absence of skin irritation of the cosmetic compositions of Example 1 and Comparative Examples 1-3, the presence or absence of skin irritation was evaluated for 10 randomly selected women aged 19 to 29 years with healthy skin.

Specifically, the presence or absence of skin irritation was evaluated before use of the cosmetic composition and at time points 1 week, 2 weeks, 4 weeks, and 6 weeks after use of the cosmetic composition. The presence or absence of skin irritation was evaluated by (number of persons who showed irritation)/(total number of test subjects).

skin irritation Example 1 0/10 Comparative Example 1 7/10 Comparative Example 2 5/10 Comparative Example 3 6/10

As shown in Table 3, there was a significant difference in the evaluation results of the presence or absence of skin irritation in Example 1 and Comparative Examples 1-3. This result means that skin irritation caused by arbutin can be significantly reduced when used in combination with arbutin as a whitening component, indigo leaf and rapeseed extract. On the other hand, it was found that the sample using a combination of indigo leaf and rapeseed whole plant extract together with niacinamide as a whitening ingredient did not reduce skin irritation caused by niacinamide.

<Experimental Example 3> Evaluation of skin soothing effect according to active ingredient content

After inducing skin irritation through the Tape Stripping Method on the inner part of the lower arm in 10 men and women in their 20s and 30s who do not currently have skin allergy symptoms, the degree of calming of the irritation caused by applying cosmetics Relative evaluation. First, skin erythema was induced by taping 30 times with general scotch tape on two inner parts of the lower arm. After erythema was induced, a cosmetic sample prepared with the active ingredient composition shown in Table 4 below was applied, and the degree of skin soothing was evaluated 3 hours after application. Here, the cosmetic sample of Table 4 below was prepared by changing only the content of component A corresponding to the composition of the active ingredient in Table 1 of Example 1, and the content of the remaining component B and the content of fragrance in component C were prepared by mixing the same did.

A scale of 1 to 5 was used as the evaluation criteria, with 0 points for 'no response', 1 point for 'very slight erythema', 2 points for 'dim or mild erythema', and 3 points for 'demarcated but weak erythema'. Dots and 'clear erythema' were marked as 4 points, and 'severe erythema' as 5 points. The experimental results are shown in Table 4 below as the average score of 10 subjects to be evaluated.

Active ingredient content (parts by weight) Degree of skin irritation (erythema) arbutin indigo leaf rapeseed outpost left right Example 1-1 5 0.8 1.75 2.5 2.6 Example 1-2 0.9 0.6 0.6 Examples 1-3 1.0 0.5 0.4 Examples 1-4 2.5 0.5 0.6 Examples 1-5 2.6 0.6 0.6 Examples 1-6 2.7 2.2 2.4 Example 2-1 5 1.75 0.8 2.7 2.9 Example 2-2 0.9 0.5 0.7 Example 2-3 1.0 0.6 0.7 Example 2-4 2.5 0.5 0.5 Example 2-5 2.6 0.7 0.5 Example 2-6 2.7 2.1 2.3

As shown in Table 4, skin irritation (erythema) was significantly lower in the samples containing 0.9-2.6 parts by weight of indigo leaf extract and 0.9-2.6 parts by weight of rapeseed extract based on 5 parts by weight of arbutin.

In particular, it can be seen that the content limit of the extracts is significant, since skin irritation is induced when the content of the extracts is out of range.

Preparation example of cosmetics

The active substance according to the present invention can be manufactured into various types of cosmetics depending on the purpose. The following exemplifies the manufacturing method of several cosmetics containing the active ingredient according to the present invention as an active ingredient, but the present invention is not limited thereto.

<Cosmeceutical preparation example 1> Preparation of softened lotion

10.0 parts by weight of active substance

1,3-butylene glycol 1.00 parts by weight

Disodium EDTA 0.05 parts by weight

0.10 parts by weight of allantoin

Dipotassium glycyrrhizate 0.05 parts by weight

citric acid 0.01 parts by weight

0.02 parts by weight of sodium citrate

Glycereth-26 1.00 parts by weight

arbutin 2.00 parts by weight

1.00 parts by weight of hydrogenated castor oil

Ethanol 30.0 parts by weight

preservative trace

trace amount of colorant

Trace amount of flavoring agent

Purified water remaining

<Cosmeceutical Preparation Example 2> Preparation of nourishing cream

10.0 parts by weight of active substance

1,3-butylene glycol 7.00 parts by weight

1.00 parts by weight of glycerin

D-panthenol 0.10 parts by weight

3.20 parts by weight of plant extract

0.30 parts by weight of magnesium aluminum silicate

1.20 parts by weight of PEG-40 stearate

2.00 parts by weight of stearic acid

1.50 parts by weight of polysorbate 60

2.00 parts by weight of lipophilic glyceryl stearate

1.50 parts by weight of sorbitan sesquioleate

3.00 parts by weight of cetearyl alcohol

4.00 parts by weight of mineral oil

Squalane 3.80 parts by weight

2.80 parts by weight of carlylic/capric triglyceride

1.80 parts by weight of vegetable oil

Dimethicone 0.40 parts by weight

Trace amount of dipotassium glycyrrhizate

allantoin traces

Sodium Hyaluronate Trace

Tocopheryl Acetate Appropriate amount

Appropriate amount of triethanolamine

Preservative amount

Appropriate amount of flavoring agent

Purified water remaining

So far, with respect to the present invention, the preferred embodiments have been looked at. Those of ordinary skill in the art to which the present invention pertains will understand that the present invention can be implemented in a modified form without departing from the essential characteristics of the present invention. Therefore, the disclosed embodiments are to be considered in an illustrative rather than a restrictive sense. The scope of the present invention is indicated in the claims rather than the foregoing description, and all differences within the scope equivalent thereto should be construed as being included in the present invention.

Claims (5)

arbutin;
Indigo ( Polygonum tinctorium ) leaf extract; and
Rape ( Brassica napus ) herb extract;
A cosmetic composition for whitening hypoallergenic skin comprising a.
The method of claim 1,
based on 5 parts by weight of arbutin;
Indigo ( Polygonum tinctorium ) leaf extract 0.1-5.0 parts by weight;
Rapeseed ( Brassica napus ) 0.1-5.0 parts by weight of a herbal extract;
A cosmetic composition for whitening hypoallergenic skin, comprising:
3. The method of claim 2,
based on 5 parts by weight of arbutin;
Indigo ( Polygonum tinctorium ) leaf extract 0.5-3.5 parts by weight;
Rape ( Brassica napus ) 0.5-3.5 parts by weight of the herb extract;
A cosmetic composition for whitening hypoallergenic skin, comprising:
4. The method of claim 3,
based on 5 parts by weight of arbutin;
Indigo ( Polygonum tinctorium ) leaf extract 0.9-2.6 parts by weight;
Rapeseed ( Brassica napus ) 0.9-2.6 parts by weight of whole herb extract;
A cosmetic composition for whitening hypoallergenic skin, comprising:
The method of claim 1,
The hypoallergenic skin whitening cosmetic composition is a cream, nourishing cream, moisture cream, hand cream, massage cream, nourishing lotion, moisture lotion, milk lotion, lotion, astringent, skin lotion, skin softener, skin toner, essence, nourishing essence, Hypoallergenic skin whitening cosmetic, characterized in that it is one or more formulations selected from the group consisting of foundation, makeup base, pack, patch, gel, powder, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion or body cleanser composition.