JP2002308750A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin care preparation capable of rapidly improving ultraviolet protection ability, preventing inflammation, rush, melanization of skin due to sunburn and further, light aging such as crease or freckle, exhibiting effect of improving pigmentation, excellent in bleaching effect, having high safety and good stability and having no problem about odor. SOLUTION: This skin care preparation is characterized by including an ultraviolet light absorbent and/or powder having ultraviolet light-scattering effect and at least one kind of plant selected from a group consisting of Caesalpinia paraensis, Anemopaegma arvense, Himatanthus sucuuba, Eupatorium triplinerve, Juglans regia, Ampelozizyphus amazonicus and Phyllanthus niruri or extracts thereof or including one or more kinds of plants selected from the above group or extracts thereof as a bleaching ingredient and/or a moisture- retaining ingredient.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin and, more particularly, to an external preparation for sunburn which can be suitably used for preventing sunburn of the skin due to ultraviolet rays and for caring for the skin after sunburn. For skin external preparations useful as, more specifically, excellent sunburn prevention effect,
It is especially effective for skin external preparations useful for UV protection, and has an excellent pigmentation-improving effect, and has excellent efficacy in preventing and improving pigmentation due to sunburn, that is, spots and freckles and liver spots. It can be suitably used as a whitening agent, and it can impart moisture to, for example, dry skin after sunburn by an excellent moisturizing effect,
In particular, the present invention relates to an external preparation for skin that can be used as a moisturizing agent, and can be used as a whitening and moisturizing agent having a moisturizing effect together with a whitening effect.

[0002]

2. Description of the Related Art It has long been known that skin is damaged by ultraviolet rays, causing erythema and spots. Therefore, in order to prevent such a situation, for example, by means of scattering ultraviolet rays or absorbing ultraviolet rays, an attempt to prevent skin tanning, prevent or improve the occurrence of erythema or spots, It has been practiced to care for the skin after sunburn, for example, by moisturizing the skin to restore it.

[0003] For this reason, ultraviolet protective agents containing an organic compound or an inorganic powder for the purpose of scattering or absorbing ultraviolet rays are widely used, but their safety and stability to cosmetics due to an increase in the amount thereof are increased. Such problems have been a problem, and a sufficiently satisfactory ultraviolet protection cosmetic has not yet been obtained. Therefore, the search for a more effective and safer UV protection agent has been a problem.

[0004] On the other hand, there are many unclear points about the mechanism of pigmentation such as skin spots and freckles, but in general, melanin pigments are excessively produced due to hormonal abnormalities and stimulation by ultraviolet rays. It is thought to be abnormally deposited in the skin.

For the purpose of preventing or improving such pigmentation, conventionally, peroxides such as hydrogen peroxide, zinc peroxide and magnesium peroxide, ascorbic acid, glutathione, colloidal sulfur and various natural products have been used. Attempts have been made to use whitening cosmetics as active ingredients. However, many of these active ingredients have insufficient safety and stability, or have problems with odor and the like, and their effects are not necessarily sufficient.

[0006] In the United States and the like, hydroquinone is used as a skin bleaching agent. This hydroquinone is irritating and allergic, and is used in cosmetics as an active ingredient from the viewpoint of safety. Has a problem.

[0007] Therefore, various studies have been conducted to develop cosmetics having a skin lightening effect without such disadvantages. Until now, a whitening external preparation using kojic acid and a kojic acid derivative (Japanese Patent Application Laid-Open JP-A-53-3538, JP-B-56
Nos. 18569, 58-22151 and 6
Nos. 0-9722 and 61-60801), cosmetics containing quercetin as an active ingredient (JP-A-55-92).
No. 305), cosmetics containing quercetin fatty acid ester as an active ingredient (Japanese Patent Application Laid-Open No. 58-131911), and cosmetics using catechin or the like as an active ingredient (Japanese Patent Application Laid-Open No. Sho 5).
2-44375) and the like.

[0008] However, in all of these cosmetics, the stability of the whitening component is still insufficient in actual use, or the effect is recognized at the cellular level, but the effect is sufficiently exhibited in humans. There was a problem that it was not performed, and it was not always satisfactory.

Further, the development of a component having a skin moisturizing effect and excellent in safety is a technique which is always desired as an external preparation for the skin, and particularly, as described above, care after sunburn accompanied by skin wounds. In products, not only whitening effect,
It is very useful if any component has a moisturizing effect.

[0010] The present invention has been made in view of the above circumstances, and is intended to prevent skin tanning or to treat the skin after tanning,
A skin external preparation that can be suitably used for dry skin and the like, and is particularly useful as a sunburn countermeasure, and has an excellent ultraviolet protection effect, is highly safe, and is suitable for ultraviolet protection. Excellent whitening effect, high safety, no problem with stability and odor, especially suitable for whitening, and excellent moisturizing effect, for example, dry skin after sunburn It is an object of the present invention to provide an external preparation for skin which can impart moisture to the skin and can be used especially as a moisturizer, and can be used as a moisturizer having a moisturizing effect as well as a whitening effect.

[0011]

Means for Solving the Problems and Embodiments of the Invention The present inventors have widely applied plants and extracts thereof to external skin preparations for ultraviolet protection in order to improve the ultraviolet protection function of ultraviolet protection cosmetics. As a result of intensive studies, among various plants, plants selected from Katingera, Katsuba, Scuuba, Aiapana, Neugera, Sarakuramyler, and Filantansnirli or extracts thereof were used as ultraviolet absorbers and / or ultraviolet scattering agents. When combined with a powder (ultraviolet scattering agent) having the above, these specific plants or extracts thereof act as an enhancer of the ultraviolet protection function, and a skin external preparation containing only conventional ultraviolet absorbers and ultraviolet scattering agents The inventors have found that a much higher ultraviolet protection effect can be obtained, and have completed the present invention.

Further, the present inventors have proposed a skin function improving effect (moisturizing effect, whitening effect, keratin improving effect) of plants and their extracts.
As a result of intensive studies on anti-aging effects), the above-mentioned Kachingera, Katsurba, Scuba, Aia Pana,
Neugera, salakoolamyler, phyllanthanisulli and their extracts give an excellent pigmentation-improving effect, and are excellent in whitening agents containing one or more of the plants selected from these or their extracts as active ingredients. Was found to have a whitening effect. Further, these plants and their extracts also have a moisturizing effect, and a moisturizer containing one or more of the plants or their extracts selected from these as an active ingredient has an excellent moisturizing effect. Therefore, it has been found that the plant or the plant extract also has a function as a whitening humectant, and has led to the present invention.

That is, the present invention comprises (1) one or more powders having an ultraviolet absorber and / or a powder having an ultraviolet scattering effect, and further comprises kachingera, catourba, scouba, eye apana, neugela, and saracu. An external preparation for skin characterized by containing one or more plants selected from the group consisting of lamboiler and phylantasnirli or an extract thereof. Here, it is more preferable that the ultraviolet absorber is a cinnamic acid-based compound or a triazine-based compound, and the powder having the ultraviolet scattering effect is zinc oxide.

Further, the present invention relates to (2) a method for whitening one or more plants selected from the group consisting of kachingera, catourba, scuba, aiapana, neugera, sarakulamyla and phylantasnirli, or an extract thereof. An external preparation for skin characterized by containing as a component and / or a moisturizing component.

Hereinafter, the present invention will be described in more detail. The first external preparation for skin of the present invention comprises an ultraviolet absorbent and / or
Alternatively, a powder having an ultraviolet scattering effect is used in combination with one or more plants selected from kachingera, catuba, scuba, eye apana, neugela, sarakulamyla, and phylantasnirli, or an extract thereof.

Here, as the ultraviolet absorber of the present invention,
The type thereof is not particularly limited, and examples thereof include a cinnamic acid ultraviolet absorber, a triazine ultraviolet absorber, a benzophenone ultraviolet absorber, a benzoic acid ultraviolet absorber, a salicylic acid ultraviolet absorber, and a dibenzoylmethane ultraviolet absorber. These can be used alone or in an appropriate combination of two or more. In the case of the present invention, among these, cinnamic acid-based ultraviolet absorbers, triazine-based ultraviolet absorbers, and the like are particularly preferable.

More specifically, examples of the cinnamic acid-based ultraviolet absorber include 2-ethylhexyl paramethoxycinnamate, isopropyl paramethoxycinnamate, diethanolamine salt of paramethoxyhydrocinnamate, and diparamethoxysilicic acid. Glyceryl cinnamate-mono-2-ethylhexanoate, methyl diisopropylcinnamate and the like can be mentioned.

Examples of the triazine-based ultraviolet absorber include 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino] 1,3,5-triazine.

As the benzophenone type ultraviolet absorber,
For example, 2-hydroxy-4-methoxybenzophenone,
2-hydroxy-4-methoxybenzophenone-5-sulfate, 2-hydroxy-4-methoxybenzophenone-5
Sodium sulfate, 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxy Benzophenone and 2-hydroxy-4-n-octoxybenzophenone are exemplified.

Examples of the benzoic acid-based ultraviolet absorber include paraaminobenzoic acid, ethyl paraaminobenzoate, butyl paraaminobenzoate, and paradimethylaminobenzoic acid2.
-Ethylhexyl, glyceryl paraaminobenzoate, amyl paraaminobenzoate and the like.

Examples of the salicylic acid type ultraviolet absorber include 2-ethylhexyl salicylate, triethanolamine salicylate, homomenthyl salicylate, dipropylene glycol salicylate, methyl salicylate, ethylene glycol salicylate, phenyl salicylate, amyl salicylate, benzyl salicylate, isopropylbenzyl salicylate, and the like. And potassium salicylate.

Examples of the dibenzoylmethane-based ultraviolet absorber include 4-t-butyl-4'-methoxydibenzoylmethane, 4-isopropyldibenzoylmethane, and 4-isopropyldibenzoylmethane.
Methoxydibenzoylmethane, 4-t-butyl-4'-
Hydroxydibenzoylmethane and the like.

As the ultraviolet absorber of the present invention, in addition to the compounds classified as described above, for example, menthyl-O-
Aminobenzoate, 2-phenyl-benzimidazole-5-sulfate, 2-phenyl-5-methylbenzoxazole, 3- (4-methylbenzylidene) camphor, 2-
Ethylhexyl-2-cyano-3,3-diphenylacrylate, 2- (2′-hydroxy-5′-methylphenyl) benzotriazole, menthyl anthranilate, and the like.

The amount of the ultraviolet absorbent in the first external preparation for skin of the present invention is not particularly limited, but is usually 0.5 to 30% (% by mass, hereinafter the same) with respect to the total amount of the preparation. ), Preferably 1 to 15%, more preferably 2 to 10%. Within this range, an excellent ultraviolet ray preventing effect can be obtained.

The type of the powder (ultraviolet scattering agent) having an ultraviolet scattering effect used in the first external preparation for skin of the present invention is not particularly limited. For example, titanium oxide, zirconium oxide, Examples thereof include metal oxides such as cerium oxide and zinc oxide, and these can be used alone or in an appropriate combination of two or more. In the case of the present invention, among these, zinc oxide and the like are particularly preferable. Examples of the ultraviolet scattering agent composed of these metal oxides also include powders whose surfaces are coated with silica gel, alumina, iron, polysiloxane, or the like.

The amount of the ultraviolet light scattering agent in the first external preparation for skin of the present invention is not particularly limited, but is usually preferably 1 to 25% based on the total amount of the above-mentioned preparation.
More preferably 1 to 15%, particularly preferably 2 to 10%
It is. Within this range, an excellent ultraviolet ray preventing effect can be obtained.

Catingueira, which is used as a plant of the external preparation for skin of the present invention, belongs to the genus Caesalpinia and is distributed in South America, and its bark and leaves are used for coughing, diarrhea, wounds and the like. ing. Philantas Niruri
(Nthus niruri) belongs to the family Euphorbiaceae (Phylanthus), and grows naturally in tropical and subtropical regions of Central and South America such as Brazil. In these areas, the plant has long been used as a folk medicine for jaundice, hepatitis and urinary diseases. Further, Catuaba belongs to the genus Anemopaegma, is distributed in tropical America, is used for fire extinguisher disease, cardiovascular disease, and is used for neuralgia, rheumatism, dysentery and the like. Scuuba is Himatants
It belongs to the genus Nthus, is distributed in tropical America, and is used for applications such as carminatives and rheumatism. Aiapana is a European Butterfly (Eupato)
Rum), which is distributed in tropical America and is used for tonic leaves, promoting digestion, preventing diarrhea, tetanus and the like. Nogueira is a walnut (Jug)
lans), which is edible in Asia, North and South America, and especially distributed in South America. Saracura-muira,
It belongs to the genus Ampelozyphis and is used in Brazil as a tonic, antipyretic, and wound medicine.

In the present invention, natural and cultivated plants can be used as the above-mentioned plants, but the plants are not limited thereto, and cultured cells such as recombinant plants, callus and hairy roots obtained by genetic recombination, Cultured tissue can also be used.

The external preparation for skin of the present invention may contain the above-mentioned plant itself or may contain an extract of the above-mentioned plant. In addition, the above-mentioned plants can use the xylem, heartwood, bark, branches, leaves, roots, bulbs, seeds, pods, fruits, flowers, and the like, and these parts are dried. It can be used as it is after being ground, or can be mixed with an extract extracted from each part. In the case of the present invention, among them, the stem, leaf, bark, root, and seed extracts are particularly desirable.

The plant extract used in the present invention may be an extract or an extract separated and purified from the extract. In the case of an extract extract, it can be obtained by solvent extraction of a dried or crushed plant, and the extract can be used as it is,
It may be used in a dilute solution diluted with an appropriate solvent. Alternatively, a concentrated extract, a dry powder by freeze-drying or the like, or a paste-like preparation can be used.

Examples of the solvent used to obtain the above plant extract include commonly used organic solvents such as methanol, ethanol, butanol, hexane, heptane, cyclohexane, ethyl acetate and acetone, and water. One of these solvents may be used alone, or two or more thereof may be used as a mixture. Among these solvents, polar solvents are preferred, and ethanol and water are more preferred.

The extraction can be carried out at a temperature of usually about 3 to 70 ° C. by a conventional method. In addition to the solvent extraction, an extract obtained by supercritical extraction in which carbon dioxide is brought into a supercritical state can be similarly used. At this time, hexane, ethanol, or the like can be used as an extraction aid. Separation and purification of the active ingredient from the extract can be performed by purifying the extract by column chromatography, liquid chromatography and the like.

In the first external preparation for skin of the present invention, the amount of the above-mentioned plant or plant extract can be appropriately changed depending on the kind and the dosage form of the above-mentioned preparation. 0.00001-20% as extract)
It is suitable to be blended, preferably 0.0001 to 1
0%, more preferably 0.001-2%. If the amount is less than 0.00001%, the effects of the present invention cannot be exhibited, and if it exceeds 20%, the feel during use may be impaired depending on the dosage form. For the same reason, the compounding ratio (mass ratio) to the ultraviolet absorber and the ultraviolet scattering agent is as follows: plant extract: ultraviolet absorber = 1: 10
000 to 10: 1, especially 1: 1000 to 1: 2, plant extract: ultraviolet scattering agent = 1: 10000 to 1: 1, especially 1:
It is more preferable to mix them in a ratio of 1000 to 1: 2.

The first external preparation for skin of the present invention is characterized in that the above-mentioned plant or plant extract functions as an agent for improving the ultraviolet protection effect of the above-mentioned ultraviolet absorber and ultraviolet scattering agent, and exhibits an excellent ultraviolet protection effect. It is useful as an external preparation for ultraviolet protection, and examples of its form are not particularly limited. For example, creams, hand creams, sprays, serums, lotions, lotions, lipsticks, foundations, whitening agents, impregnated sheets, patches Skin cosmetics, ointments, dispersants, etc.
It can be in the form of quasi-drugs such as creams and liquids for external use and skin external preparations such as pharmaceuticals, and by using ordinary dosages in these forms in the usual manner, excellent skin preparations for ultraviolet protection are obtained. Function is exhibited.

As the first external preparation for skin of the present invention, known components according to the kind and dosage form can be used as long as the effects of the present invention are not impaired. An external preparation for skin can be prepared by using the above essential components and, if necessary, these compounding components in accordance with the conventional method of each preparation.

Examples of the above components include polymer compounds, humectants, antioxidants, oily components such as mineral oils and natural fats and oils, surfactants, thickeners, alcohols, silicones, powder components, pigments, vitamins and the like. , Water, preservatives, other plant extracts, various skin activators, and the like can be appropriately added as necessary.

In addition, sequestering agents such as disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, caffeine, tannin, verapamil, tranexamic acid and derivatives thereof, licorice Extract, glabridine,
Hot water extract of fire thorn fruit, various crude drugs, tocopherol acetate, glycyrrhizic acid and its derivatives or salts thereof, drugs such as anti-inflammatory agents, ellagic acid, vitamin C, magnesium ascorbate phosphate, ascorbic acid glucoside, arbutin, Whitening agents (components) such as kojic acid and sugars such as glucose, fructose, mannose, sucrose, trehalose and the like can also be appropriately compounded.

Here, the above-mentioned plant or plant extract of the first external preparation for skin of the present invention has a whitening effect and a moisturizing effect, as described in detail below. An external preparation for skin containing an ultraviolet scattering agent and the plant or plant extract not only exhibits an excellent ultraviolet protection function, but also can exhibit a whitening effect on the skin after sunburn and a moisturizing effect. It is particularly useful as a skin external preparation for protection against ultraviolet rays such as a protective and ultraviolet care preparation. In addition, when using catourba as a plant of the first external preparation for skin, among the above compounds, octyl p-methoxycinnamate, zinc oxide and octyltriene are particularly used as the ultraviolet absorber and / or ultraviolet scattering agent to be used in combination therewith. The use of a combination of Azone and zinc oxide, or titanium oxide and zinc oxide is particularly effective and preferred. In addition, when phylantanil is used as the first skin external preparation plant, a combination of octyl triazone and zinc oxide is used among the above compounds as the ultraviolet absorber and / or ultraviolet scattering agent used in combination therewith. Then, it is particularly effective and preferable.

Next, the second skin external preparation of the present invention will be described in more detail. Here, the second skin external preparation of the present invention is, as described above, one or two or more plants selected from Katingera, Cathaba, Scuoba, Aia Pana, Neugera, Sarakuramuiler, and Filantansnirli, particularly Because the extract contains a whitening component and a moisturizing component, in the present invention, kachinella,
Catourba, scuba, eye apana, neugela, sarakulamyla, filantasniruri may be contained as a component exhibiting both a whitening effect and a moisturizing effect, and one or more plants selected from these plants In particular, an external preparation for skin containing the extract is useful not only as an external preparation for skin whitening and an external preparation for skin moisturizing, but also as an external preparation for skin whitening and moisturizing. These plants and plant extracts are as described above.

The amount of the plant or its extract to be added to the second external preparation for skin of the present invention varies depending on the dosage form, but is usually 0.00% (as an extract) relative to the total amount of the preparation.
It is suitable to mix 001 to 20%, preferably 0.001 to 10%, more preferably 0.001 to 2%. If the amount is less than 0.00001%, the effect of the present invention may not be exhibited, and if the amount is too large,
Some dosage forms make production difficult.

The form of the dosage form of the second external preparation for skin of the present invention is arbitrary, and these dosage forms may be added to the above-mentioned plant and / or plant according to the kind within a range that does not impair the effects of the present invention. In addition to the extract, it is possible to mix appropriate components that are usually added to the external preparation for skin, and the second external preparation for skin of the present invention is obtained by mixing the above essential components and the above optional components as necessary. It can be prepared according to the conventional method of the form.

As described above, the second external preparation for skin of the present invention includes various components usually used in the external preparation composition for skin, such as oils, water, surfactants, polymer compounds, silicones, Other moisturizers (components), alcohols, thickeners, antioxidants, vitamins, mineral oils, oily components such as natural fats and oils, sequestering agents, pH adjusters, preservatives, other plant extracts, fragrances , Pigments, and other whitening agents (ingredients) such as ellagic acid, arbutin, kojic acid, vitamin C, anti-inflammatory agents, skin activators, ultraviolet light scattering agents,
An ultraviolet absorber or the like can be blended.

The second external preparation for skin of the present invention can be used in a usual dose in the usual manner of using the dosage form. For example, the dose per administration is 2 μg as a preparation per 1 cm ^{2 of} application area. Approximately 2 mg, 3 times a day is common.
The second external preparation for skin of the present invention exerts an excellent pigmentation improving effect and a moisturizing effect by being used as described above.

[0044]

Next, the present invention will be described in more detail with reference to experimental examples and examples, but the present invention is not limited thereto. In addition, the following compounding amounts are mass% unless otherwise specified. First, a method for preparing a plant extract used in the following experimental examples will be described.

<Preparation of Samples> 10 times (W / V) of 1 kg of cut material such as seeds, leaves, roots, stems and bark of kachingera, phyllantasnulli, catuba, scuba, aiapana, neugera, sarakulamyla ) And extracted for 2 hours. Next, the mixture was filtered and ethanol was distilled off under reduced pressure to obtain a plant extract used in the following experimental examples.

Experimental Example 1 The above plant extract was 2% and octyl paramethoxycinnamate was used as an ultraviolet absorber.
An emulsion (external preparation for skin) mixed with the following common composition (O / W emulsion) so as to be 5% was used as a sample of Experimental Example 1.

Common composition: decaglyceryl monostearate 1%, liquid paraffin 3%, sorbitan monostearate 1.5%, POE monostearate (20)
Sorbitan 1.5%, Acrylic acid alkyl methacrylate copolymer (PEMULENTR-2, Goodrich) 1%, Behenyl alcohol 1%, Triisopropanolamine 0.75%, Glycerin 3%, Purified water Balance, 100% in total

<Evaluation of Erythema Inhibition by Animal Experiment> An erythema inhibition test by ultraviolet rays was performed using guinea pigs. The back skin of the guinea pig from which hair had been removed was irradiated with ultraviolet UVB twice the minimum erythema dose (2 MED). The sample was applied immediately after irradiation (application amount: about 2 mg / cm ² ), and the state of erythema 24 hours later was evaluated based on the following criteria. For guinea pigs, a test was conducted with six animals as one group, and the total of the evaluation points was also shown in Table 1 as a result.

<Evaluation Criteria> Skin condition erythema score No erythema was observed 0 Slight erythema was recognized 1 Erythema with unclear border was recognized 2 Erythema with clear border was recognized 3 Erythema with edema was recognized 4

[0050]

[Table 1] Aloe extract: manufactured by Lion Corporation (the same applies hereinafter)

From the results in Table 1, it can be seen that the emulsion containing the plant extract and the ultraviolet protective agent (absorber) is more synergistic with the plant extract and the ultraviolet protective agent than the emulsion containing these alone. , The erythema-suppressing effect is markedly improved. In other words, it is clear that an emulsion containing the above plant extract and an ultraviolet absorber is excellent in the effect of preventing skin damage due to ultraviolet rays, and is useful as an external preparation for ultraviolet protection skin.

[Experimental Example 2] The effect of the above-described plant extract on the pigmentation of guinea pigs after sunburn was examined.
7 week old colored guinea pigs with UVB (2 / 5ME)
D) was irradiated once a day for one week to promote pigmentation. Thereafter, a 90% propylene glycol solution containing 1.0% of the plant extract was used as a sample, and 0.020 mL / cm
² , applied once a day for 4 weeks (six different back skins of an individual were used for evaluation per sample). After the application for 4 weeks, the skin lightness was visually evaluated. In addition, the visual judgment was performed by five evaluators according to the following judgment criteria with the uncoated portion as a control, and the average score was used as the score. Table 2 shows the results.

<Judgment Criteria> 4: Pigmentation was clearly improved. 3: Pigmentation is improved. 2: Slightly improved pigmentation 1: Slightly improved pigmentation 0: Equivalent to no application, or pigmentation is promoted.

[0054]

[Table 2]

From the results shown in Table 2, a strong pigmentation-improving effect was observed for all extracts, and it was confirmed that these plant extracts were useful as whitening agents.

Next, the effect of improving the moisture retention of the plant extract exhibiting an excellent whitening effect was evaluated by Experimental Example 3.

[Experimental Example 3] Hartley-type guinea pig (6
(Week-old, female) was immersed in an acetone / ether = 1/1 solution to prepare dry skin, and a test solution was applied for 2 weeks in the same manner as in the whitening test. Thereafter, the skin water content was measured with a Scalar Moisture Checker.
Table 3 shows the results.

[0058]

[Table 3]

According to the results in Table 3 above, extracts from Katingella, Filanthus Nurli, Catuba, Scuoba, Aia Pana, Neugera, and Sarakuramyler were:
It is recognized that they have an excellent moisturizing effect, and that these plant extracts are useful as moisturizers. Therefore, the above plant extract is also useful as a whitening humectant.

The following is an example in which the above plant extract is blended. In addition, each plant extract was extracted from each part shown below of each plant in the same manner as in the above experimental example. The following examples contain a plant extract that is expected to have excellent erythema-suppressing, whitening, and moisturizing effects.

In Examples 1 to 7, the following oil phase components and aqueous phase components were separately heated at 70 ° C., and then mixed and emulsified. While cooling, a fragrance was added on the way, and further cooled to room temperature to obtain the skin external preparations of Examples 1 to 7.

Example 1 (Cream) Ingredient Ingredient Content (% by mass) Katingella (Caesalpinia paraens)
is), Phyllanthus (Phylanthus)
niruri), Catourba (Anemopaegm)
a arvense), scuba (Himatant)
hus sukuba), eye apana (Eupat)
orium triplinerve), Neugera (J
Uglan's Regia), Sarakuramuila (A)
mplozizyphus amazonicus)
Seed ethanol extract 0.20 each, octyl paramethoxycinnamate 4.00, octyl triazine 1.
00, zinc oxide 3.00, titanium oxide 5.00, dimethoxybenzylideneoxoimidazolidin octyl propionate 1.00, 4t-butyl 4'methoxybenzoylmethane 0.1, EDTA2Na 1.00, eucalyptus extract 0.5, Ellag Acid (particle size 10μm)
0.30, bentonite 1.00, hexaglyceryl monostearate 1.00, diglyceryl monoisostearate 0.50, glyceryl monostearate 1.50, liquid paraffin 10.00, solid paraffin 1.50, dimethyl silicon 3.00, cetyl palmitate 2.00, cetostearyl alcohol
00, glycerin 12.00, 1,3-butylene glycol 2.00, carboxyvinyl polymer (molecular weight 1,000,000 to 1.5 million) 0.08, xanthan gum
0.10, propylparaben 0.10, methylparaben 0.40, purified water balance, trace amount of sodium hydroxide, trace amount of fragrance, total 100.0

The cream may be applied to the skin as it is, but can also be used as an impregnated sheet or the like. The sheet used here is not particularly limited, and for example, any of woven or non-woven fabric of natural fibers or synthetic fibers can be used. Specific examples include woven or non-woven fabrics such as rayon, acetate, acrylic, polyester, polyethylene, polypropylene, polyurethane, polyamide, and cotton, and paper tissue (made of natural pulp). The impregnation amount is 0.1 to 50 g /
g is desirable.

[Example 2] (External preparation for ultraviolet protection skin) Component Content (% by mass) Katingella (Caesalpinia paraens)
is), Phyllanthus (Phylanthus)
niruri), Catourba (Anemopaegm)
a arvense), scuba (Himatant)
hus sukuba), eye apana (Eupat)
orium triplinerve), Neugera (J
Uglan's Regia), Sarakuramuila (A)
mplozizyphus amazonicus)
Leaf ethanol extract 0.20 each, methyl diisopropylcinnamate 4.00, menthyl-O-aminobenzoate 2.00, zinc oxide 1.00, 2,4,6
-Tris [4- (2-ethylhexyloxycarbonyl) anilino] 1,3,5-triazine 1.00,4
-T-butyl-4'methoxybenzoylmethane 2.0
0, titanium oxide 5.00, saponite 1.00, natural hectorite 0.50, decaglyceryl monostearate 0.80, tetraglyceryl monoisostearate 0.50, hexaglyceryl monostearate
0.20, diglyceryl oleate 0.30, glyceryl monostearate 0.30, sorbitan monostearate 0.30, POE40 glyceryl monostearate 0.80, POE100 hydrogenated castor oil 0.2
0, stearyl glycyrrhetinate 0.30, ellagic acid 0.50, cetyl palmitate 0.50, isopropyl palmitate 0.50, isocetyl isostearate 0.80, cyclic silicon 2.00, dimethyl silicon 1.00, squalane 4 .00, sunflower oil
1.0, lecithin 1.00, cetostearyl alcohol 1.50, behenyl alcohol 0.50, glycerin 5.00, 1,3-butylene glycol 2.0
0, dipropylene glycol 1.00, carboxyvinyl polymer (molecular weight 1,000,000 to 1.5 million) 0.0
5, xanthan gum 0.30, propylparaben
0.10, EDTA · 2Na 0.50, Vitamin E
0.1, tocopherol acetate 0.1, citric acid trace, sodium citrate trace, triisopropanolamine 0.20, purified water balance, total 100.0

[Example 3] (Hand cream) Ingredients Compounding amount (% by mass) Katingella (Caesalpinia paraens)
is), Phyllanthus (Phylanthus)
niruri), Catourba (Anemopaegm)
a arvense), scuba (Himatant)
hus sukuba), eye apana (Eupat)
orium triplinerve), Neugera (J
Uglan's Regia), Sarakuramuila (A)
mplozizyphus amazonicus)
Root ethanol extract of each 0.20, ethylhexyl methoxycinnamate 3.00, dihydroxybenzophenone 0.5, amyl paraaminobenzoate 0.5, homomenthyl salicylate 1.5, 2, phenylbenzimidazole pentasulfate 0.3, plant Squalane 5.0, jojoba oil 3.0, dimethyl silicon 2.0, isopropyl myristate 1.5, decaglycerin monoisostearate 1.0, decaglycerin triisostearate 0.5, glycerin monostearate 1 2.0, stearic acid 1.5, POE (20) glyceryl monostearate 0.8, glycyrrhetinic acid 0.1, glycerin 3.0, 1,3-butylene glycol 5.0,
Rosehip oil 0.2, Triisopropanolamine 0.1, Proline 0.1, Ethanol 2.0, Hydrogenated soybean phospholipid 1.0, Ketoconazole-Vegum T complex 0.25, Carboxyvinyl polymer
0.1, citric acid 0.1, fragrance trace, purified water balance, total 100.0

[Example 4] (Emulsion) Ingredients Compounding amount (% by mass) Katingella (Caesalpinia paraens)
is), Phyllanthus (Phylanthus)
niruri), Catourba (Anemopaegm)
a arvense), scuba (Himatant)
hus sukuba), eye apana (Eupat)
orium triplinerve), Neugera (J
Uglan's Regia), Sarakuramuila (A)
mplozizyphus amazonicus)
0.20,2,2 ', 4
4'-tetrahydroxybenzophenone 0.5, butyl paraaminobenzoate 0.50, homomenthyl salicylate 0.50, 3- (4-methylbenzylidene) camphor 0.50, titanium oxide 5.00, dimethoxybenzylideneoxoimidazolidinpropionate Octyl 1.00, Montmorillonite 1.00, Decaglyceryl triisostearate 0.50, Decaglyceryl monostearate 1.60, Dipotassium glycyrrhizinate 0.20, Cyclic silicon 0.50, Vegetable squalane 5.50, Jojoba Oil 3.00, almond oil 0.50, macadamia nut oil 0.50, sunflower oil 0.50, hydrogenated soybean phospholipid 0.80, behenyl alcohol 1.00, glycerin 7.00, carboxyvinyl polymer (molecular weight 1,000,000 to 1 00000)
0.10, xanthan gum 0.10, propylparaben 0.10, methylparaben 0.40, tocopherol acetate 0.20, arginine 0.10, purified water
Balance, ethanol 2.00, fragrance trace, total 1
00.0

The emulsion may be applied to the skin as it is, but it can also be used as a spray or an impregnated sheet. The sheet used here is not particularly limited, and for example, any of woven or non-woven fabric of natural fibers or synthetic fibers can be used. Specifically, for example, a woven or non-woven fabric such as rayon, acetate, acrylic, polyester, polyethylene, polypropylene, polyurethane, polyamide, and cotton, and a paper tissue (made of natural pulp) are used. Impregnation amount is 0.1-5
0 g / g is desirable.

[Example 5] (Lotion) Ingredients Compounding amount (% by mass) Katingella (Caesalpinia paraens)
is), Phyllanthus (Phylanthus)
niruri), Catourba (Anemopaegm)
a arvense), scuba (Himatant)
hus sukuba), eye apana (Eupat)
orium triplinerve), Neugera (J
Uglan's Regia), Sarakuramuila (A)
mplozizyphus amazonicus)
0.20, 2-hydroxy-4-methoxybenzophenone-5-sulfuric acid 3.00,
Paramethoxyhydrocinnamic acid diethanolamine
2.00, decaglyceryl monolaurate 0.20,
Diglyceryl monoisostearate 0.10, POE
(25) Oleyl ether 0.80, rose water 0.
10, glycerin 7.00, carboxyvinyl polymer (molecular weight 1,000,000 to 1.5 million) 0.10, methylparaben 0.40, propylparaben 0.10, triisopropanolamine 0.05, purified water balance, ethanol 10.00, fragrance Trace, total 10
0.0

This lotion may be applied as it is to the skin, but it can also be used as a spray, an impregnated sheet, or the like.

Example 6 (Essence) Component Content (% by mass) Katingella (Caesalpinia paraens)
is), Phyllanthus (Phylanthus)
niruri), Catourba (Anemopaegm)
a arvense), scuba (Himatant)
hus sukuba), eye apana (Eupat)
orium triplinerve), Neugera (J
Uglan's Regia), Sarakuramuila (A)
mplozizyphus amazonicus)
0.20 each for leaf ethanol extract, titanium oxide
0.1, sugar cinnamic acid derivative 3.0, 2-hydroxy-4
Methoxybenzophenone 5-sulfonic acid 3.00, glabridine 0.5, liquid paraffin 3.0, squalane 10.0, cetostearyl alcohol 4.0,
Beeswax 2.0, glyceryl monostearate 2.
0, POE (20) sorbitan monolaurate 2.
0, glycolic acid 0.2, salicylic acid 0.1, pharmacopeia 5.0, diglycerin 5.0, montmorillonite 1.0, trimethylglycine 0.3, sodium hydroxide trace, perfume trace, purified water balance, total 100.0

The serum may be applied to the skin as it is, but it can also be used as a spray or an impregnated sheet. The sheet used here is not particularly limited, and for example, any of woven or non-woven fabric of natural fibers or synthetic fibers can be used. Specifically, for example, rayon, acetate, acrylic, polyester,
Examples include woven or non-woven fabrics such as polyethylene, polypropylene, polyurethane, polyamide, and cotton, and paper tissue (made of natural pulp). Impregnation amount is 0.1-5
0 g / g is desirable.

[Example 7] (Whitening agent) Ingredients Compounding amount (% by mass) Katingella (Caesalpinia paraens)
is), Phyllanthus (Phylanthus)
niruri), Catourba (Anemopaegm)
a arvense), scuba (Himatant)
hus sukuba), eye apana (Eupat)
orium triplinerve), Neugera (J
Uglan's Regia), Sarakuramuila (A)
mplozizyphus amazonicus)
Bark ethanol extract 0.20 each, alumina-polysiloxane coated ultrafine titanium oxide 2.00, cerium oxide 0.10, 2-ethylhexyl salicylate
1.00, liquid paraffin 10.0, isopropyl myristate 1.5, glycerin monostearate
1.0, stearic acid 1.5, POE (20) stearyl alcohol 0.8, glycyrrhetinic acid 0.1,
Oxidized CoA 0.1, glycerin 3.0, proline 0.1, ethanol 2.0, ellagic acid 0.5, cotoconazole 0.10, veegum 0.3, carboxyvinyl polymer (molecular weight 1,000,000 to 1.5 million) 0 .
1. Titanium oxide containing iron 4.00, trace amount of fragrance, purified water balance, total 100.0

[Example 8] (Lotion) Ingredient Ingredient Content (% by mass) Katingella (Caesalpinia paraens)
is), Phyllanthus (Phylanthus)
niruri), Catourba (Anemopaegm)
a arvense), scuba (Himatant)
hus sukuba), eye apana (Eupat)
orium triplinerve), Neugera (J
Uglan's Regia), Sarakuramuila (A)
mplozizyphus amazonicus)
Root ethanol extract 0.20 each, triethanolamine salicylate 1.5, 2,2 ′, 4,4′-tetrahydroxybenzophenone 1.5, 2,4,6-tris [4- (2-ethylhexyloxy) Carbonyl) anilino] 1,3,5-triazine 0.5, glycerin 5.0, 1,3-butylene glycol 5.0, carboxyvinyl polymer 0.5, potassium hydroxide trace amount,
Tocopheryl acetate 0.2, Coleus extract 0.
3, decaglyceryl monoisostearate 1.0, decaglyceryl tristearate 0.5, ethanol
1.0, POE (40) hydrogenated castor oil 0.5, Darbilia extract 0.2, trimethylglycine 3.0, pyroctone olamine 0.5, eucalyptus extract 0.5, Bentley 0.5, pyrocton olamine -Benclay S
L complex 0.25, fragrance trace, purified water balance,
Total (% by mass) 100.0

The lotion may be applied as it is to the skin, but it can also be used as a spray, an impregnated sheet, or the like. As the sheet used here,
There is no particular limitation, and for example, any of woven or non-woven fabric of natural fibers or synthetic fibers can be used. Specifically, for example, rayon, acetate, acrylic, polyester, polyethylene, polypropylene, polyurethane,
Examples include woven or non-woven fabrics such as polyamide and cotton, and paper tissue (made of natural pulp). The impregnation amount is 0.
1 to 50 g / g is desirable.

[Example 9] (Patch) Ingredient Ingredient Content (% by mass) Katingella (Caesalpinia paraens)
is), Phyllanthus (Phylanthus)
niruri), Catourba (Anemopaegm)
a arvense), scuba (Himatant)
hus sukuba), eye apana (Eupat)
orium triplinerve), Neugera (J
Uglan's Regia), Sarakuramuila (A)
mplozizyphus amazonicus)
Ethanol extract of leaves 0.20 each, zinc oxide 4.
0, octyl triazine 3.0, trimethyl glycine 0.2, glabridine 0.1, polyacrylic acid
4.0, sodium polyacrylate 1.5, carboxymethylcellulose 4.0, glycerin 15.0,
Sorbitol 10.0, dihydroxyaluminum amino acetate 0.10 kaolin 0.05, montmorillonite 4.0, polysorbate 80 1.0,
1,3-butylene glycol 3.0, dimethylpolysiloxane (30 cst) 1.0, purified water balance,
Total (% by mass) 100.0

The above-mentioned components were mixed with a kneader until a paste was formed to obtain a patch composition. The patch composition of Example 9 was prepared by uniformly applying the patch composition to 150 g / cm ² on a nonwoven fabric and applying a polyethylene film.

[0077]

According to the present invention, kachinella, phyllantasnirli, catourba, scuba, eye apana,
Prevention of ultraviolet rays such as erythema-suppressing action inherently possessed by ultraviolet ray protective agents by using a plant selected from Neugera or Salakhumyla or an extract thereof in combination with an ultraviolet ray protective agent (ultraviolet ray absorbent, ultraviolet ray scattering agent) The function is drastically improved, and a skin external preparation which is very effective for UV protection can be obtained. In addition, by the plant, plant extract,
Has an excellent pigmentation improving effect,
Lightening of spots, freckles, melasma, pigmentation after inflammation,
It has an excellent effect on whitening, is excellent in safety, has good stability, has no problem with odor, is a skin external preparation useful for whitening, has excellent moisturizing effect, safety,
A skin external preparation having good stability and useful as a moisturizing agent, and a skin external preparation useful as a whitening and moisturizing agent having both a whitening effect and a moisturizing effect can be obtained. Further, a skin external preparation for ultraviolet protection and ultraviolet care having all of the above properties can be obtained. Therefore, the external preparation for skin of the present invention is particularly useful as an external preparation for skin against ultraviolet rays.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/48 A61K 7/48 31/216 31/216 31/53 31/53 33/30 33/30 35 / 78 35/78 CJ LT W A61P 17/16 A61P 17/16 43/00 111 43/00 111 F term (reference) 4C083 AA082 AA111 AA112 AA122 AB032 AB112 AB211 AB212 AB242 AB432 AB442 AC012 AC022 AC072 AC102 AC122 AC132 AC172 AC182 AC242 AC302 AC312 AC341 AC342 AC422 AC432 AC442 AC472 AC482 AC532 AC542 AC552 AC582 AC782 AC792 AC842 AC851 AC852 AC912 AC932 AD042 AD092 AD112 AD152 AD172 AD272 AD352 AD392 AD572 AD662 BB46 CC02 CC04 CC05 DD12 DD23 DD27 DD31 EE12 AA03A03 MA02 MA04 MA63 NA14 ZA89 ZC02 4C088 AB12 AB26 AB46 AB59 AC03 AC04 AC05 AC06 AC11 AC13 BA07 BA08 BA09 BA10 CA05 CA06 CA07 CA09 CA14 MA02 MA06 MA07 MA08 M A09 MA63 NA14 ZA89 ZC02 4C206 AA01 AA02 DB22 DB43 MA02 MA03 MA04 MA11 MA12 MA30 MA83 NA14 ZA89 ZC02

Claims (3)

[Claims] Claims 1. An ultraviolet absorber and / or one or more powders having an ultraviolet scattering effect, further comprising a katingera, a catuba, a scuba, an aipana, a neugela, a sarakulamyla, or a filantansnulli. An external preparation for skin, comprising one or more plants selected from the group or an extract thereof. 2. The external preparation for skin according to claim 1, wherein the ultraviolet absorbent is a cinnamic acid-based compound or a triazine-based compound, and the powder having the ultraviolet scattering effect is zinc oxide. 3. A kachingera, a catuba, a scuba,
An external preparation for skin, comprising one or more of a plant selected from the group consisting of Aiapana, Neugera, Salakuramuyler, and Filanthanesulli or an extract thereof as a whitening component and / or a moisturizing component.