KR102027647B1 - Low irritating cosmetic composition for skin whitening comprising albutin - Google Patents

Abstract

The present invention relates to a cosmetic composition for skin whitening comprising arbutin, niacinamide, aloe vera leaf extract, acerola extract, green tea extract, broccoli extract, jojoba seed oil and amino acid complex as an active ingredient, the skin whitening according to the present invention The cosmetic composition for it may exhibit a skin calming effect to alleviate skin irritation that may be caused when using arbutin and niacinamide, and has an excellent skin whitening effect.

Description

Low irritating cosmetic composition for skin whitening comprising albutin}

The present invention relates to a cosmetic composition for hypoallergenic skin whitening comprising arbutin, niacinamide and skin soothing ingredients as an active ingredient.

Human skin color is determined by the concentration and distribution of melanin in the skin. In addition to genetic factors, it is also influenced by environmental or physiological conditions such as ultraviolet rays, fatigue and stress. Melanin is synthesized in melanocytes in the epidermal layer of the skin, and the enzyme tyrosinase acts on tyrosine, a type of amino acid, in the melanocytes (melanosome), which is an organelle of melanocytes, and dopaquinone (DOPA) and dopaquinone. It is produced by non-enzymatic oxidation. When such synthesis of melanin occurs excessively in the skin, the skin tone is darkened, and the appearance of spots, freckles, and the like. Therefore, by inhibiting the synthesis of melanin pigment by inhibiting the tyrosinase activity in the skin, not only can brighten the skin tone to realize skin whitening, but also skin hyperpigmentation such as blemishes and freckles caused by ultraviolet rays, hormones and genetic causes Can improve deposition.

As a substance capable of inhibiting the activity of tyrosinase, various extracts including hydroquinone, ascorbic acid, kojic acid, glutathione, arbutin and lettuce extract have been used, but have problems in skin safety and stability of cosmetic formulations. In the case of arbutin, there is a problem that side effects causing skin irritation appear.

Against this background, the present inventors continued to develop substances having a whitening effect and low human side effects such as skin irritation, and as a result, they contained arbutin, niacinamide, aloe vera leaf extract, acerola extract, green tea extract and broccoli extract. While showing an excellent whitening effect of the cosmetic composition to be confirmed that the skin irritation is relieved, the present invention was completed.

Korean Patent Registration No. 10-0923141 Korean Patent Publication No. 10-2010-0069759

Therefore, an object of the present invention is an albutin, niacinamide, aloe barbadensis leaf extract, acerola (Malpighia emarginata fruit) extract, green tea (Camellia sinensis leaf) having a skin irritation and whitening effect It is to provide a cosmetic composition for skin whitening comprising an extract and broccoli (Brassica oleracea var.Italica) extract as an active ingredient.

In order to achieve the object of the present invention as described above, the present invention is arbutin (albutin), niacinamide (niacinamide), Aloe barbadensis leaf extract, Acerola (Malpighia emarginata fruit) extract, green tea (Camellia sinensis leaf) It provides a cosmetic composition for skin whitening comprising an extract and broccoli (Brassica oleracea var.Italica) extract as an active ingredient.

The present invention also provides a cosmetic composition for skin whitening further comprising jojoba seed oil (Simmondsia chinensis seed oil) and amino acid complex in the cosmetic composition for skin whitening.

Arbutin, niacinamide, aloe vera leaf extract, acerola extract, green tea extract, broccoli extract, jojoba oil and amino acid complex of the present invention for skin whitening cosmetic composition may be induced skin when using arbutin and niacinamide It has a skin calming effect to alleviate irritation, and has an excellent skin whitening effect, which can be usefully used as a cosmetic composition for whitening.

The inventors of the present invention, albutin (niabutamide), niacinamide (Aloe barbadensis leaf) extract, acerola (Malpighia emarginata fruit) extract, green tea (Camellia sinensis leaf) extract, Brossica (Brassica oleracea var. Italica) extract, The present invention has been completed by discovering that cosmetic compositions containing jojoba seed oil and amino acid complex exhibit not only a whitening effect but also a skin soothing effect.

Particularly, in the present invention, when the cosmetic composition of arbutin, niacinamide, aloe vera leaf extract, acerola extract, green tea extract and broccoli extract is used, the whitening effect is remarkably improved compared to the composition containing some of these components. Proved (see Experimental Example 1).

Therefore, the present invention is arbutin (albutin), niacinamide (niacinamide), Aloe barbadensis leaf extract, Acerola (Malpighia emarginata fruit) extract, green tea (Camellia sinensis leaf) extract and broccoli (Brassica oleracea var. Italica) It is characterized by providing a cosmetic composition for skin whitening comprising the extract as an active ingredient.

Arbutin (albutin) of the present invention is a substance contained in a large amount in the bilberry tree is a good effect on the whitening, chemical structure similar to hydroquinone which is a melanin suppression component, antioxidant, skin conditioner, whitening effect Of course, it is a material widely used worldwide because of the stability of the formulation.

The niacinamide of the present invention is a kind of niacin, which is a vitamin B group, and niacinamide is a water-soluble vitamin B3 also known as nicotinamide. Along with ceramide, it simultaneously promotes the synthesis of cholesterol and fatty acids necessary for lamellar structure formation, thereby reducing the loss of moisture in the epidermis and improving the lipid content, and is used to obtain a whitening effect in the cosmetic field.

Aloe barbadensis leaf (Aloe Vera) of the present invention is native to the Mediterranean and Africa, vitamins A, C, D, E, B12, fatty acids, amino acids, selenium, calcium and aloin (aloin), It contains about 300 different ingredients such as aloesin. Gel sap contained in the leaves is known to be effective in treating burns and arthritis.It is used for various purposes such as raw materials and foods for cosmetics and pharmaceuticals, and it is used for neutralizing toxins, restoring fatigue and neutralizing skin, fever and constipation. And ulcers.

The acerola of the present invention (Malpighia emarginata fruit (Acerola)) is a fruit produced from the shrub of Malpigia native to Brazil, contains vitamins, minerals, and the like, particularly rich in vitamin C. In addition, it is known that anthocyanins and polyphenols, which are antioxidants, are excellent in anti-aging effect, and have a skin cleansing effect, a moisturizing effect, and astringent effect.

The green tea of the present invention (Camellia sinensis leaf) is produced by inactivating the oxidase present in the tea leaves with heat or steam using buds or leaves of Camellia sinensis belonging to the Camellia family It has been drinking as a symbol difference since BC. As the pharmacological mechanisms of the various components of green tea are gradually revealed, their value is also recognized by the general public, including antioxidants, anti-inflammatory, anti-mutation, heart disease prevention, anti-angiogenesis, cell death, obesity prevention, Pharmacological actions such as lowering cholesterol, anti-arteriosclerosis, anti-diabetic, antibacterial, anti-viral, anti-aging have been known.

The broccoli of the present invention (Brassica oleracea var.Italica (Broccoli)) is a plant belonging to the cruciferous family, and contains a large amount of beta-carotene, rutin, ascorbic acid, selenium, quercetin, glutathione, etc., having antioxidant activity, calcium, Contains nutrients such as vitamin C and folic acid. Broccoli is effective in increasing collagen synthesis in the skin, preventing skin aging, improving skin resistance from harmful substances, imparting tension to the skin, and helping the pores to converge.

The aloe vera leaf extract, acerola extract, green tea extract and broccoli extract according to the present invention can be used to isolate and obtain the extract using the extraction and separation methods known in the art, the extract defined in the present invention It can be extracted from the aloe vera leaf, acerola, green tea or broccoli using a suitable solvent. In this case, any suitable solvent that may be used to obtain the extract may be used as long as it is a solvent acceptable in the art, and water or an organic solvent may be used. For example, alcohol having 1 to 4 carbon atoms, acetone, ether including purified water, methanol, ethanol, propanol, isopropanol, butanol, etc. , Various solvents such as benzene, chloroform, ethyl acetate, methylene chloride, hexane and cyclohexane may be used alone or in combination. It is not limited.

As the extraction method, any one of hot water extraction method, cold leaching extraction method, reflux cooling extraction method, solvent extraction method, steam distillation method, ultrasonic extraction method, elution method and compression method can be used. In addition, the desired extract may further be subjected to a conventional fractionation process, it may be purified using conventional purification methods. There is no limitation to the method of preparing the extract of the present invention, any known method may be used.

For example, the aloe vera leaf, acerola, green tea, and broccoli extract contained in the composition of the present invention may be used as it is while the primary extract extracted by the solvent extraction method is centrifuged, filtered, concentrated and freeze-dried and stored in a refrigerator compartment. Alternatively, the primary extract may be prepared in a powder state by an additional process such as vacuum distillation and freeze drying or spray drying. In addition, the primary extract is further purified using a variety of chromatography, such as silica gel column chromatography, thin layer chromatography, high performance liquid chromatography, etc. You can also get

Therefore, in the present invention, the aloe vera leaf, acerola, green tea or broccoli extract is a concept including all the extracts, fractions and purified products obtained at each step of extraction, fractionation or purification, their dilutions, concentrates or dried products.

The cosmetic composition for skin whitening according to the present invention is based on 100 parts by weight of the total cosmetic composition 4.0 to 6.0 parts by weight of arbutin, 1.0 to 3.0 parts by weight of niacinamide, 0.05 to 0.15 parts by weight of aloe vera leaf extract, 0.05 to 0.15 parts by weight of acerola extract Part, may include 0.05 to 0.15 parts by weight of green tea leaf extract and 0.05 to 0.15 parts by weight of broccoli extract.

In addition, the cosmetic composition for skin whitening according to the present invention may further comprise a jojoba seed oil (Simmondsia chinensis seed oil) and amino acid complex (amino acid complex).

The jojoba seed oil of the present invention (Simmondsia chinensis (jojoba) seed oil) is an oil obtained by cold pressing method from the jojoba seed, because the chemical structure is similar to the skin sebum and penetrates well into the skin while sticking and thickly applied while carpentry It is known to be effective for sensitive skin because it regulates sebum and prevents skin tissue cell regeneration effect, as well as moisturizing effect, and has anti-inflammatory effect and anti-inflammatory function without skin irritation.

The amino acid complex of the present invention is a complex of amino acids of the same or similar composition as the amino acid composition in the stratum corneum, the amino acid complex is an important role in maintaining the moisturizing power to supply skin cells and activate skin fibroblasts It is known to do.

The amino acid complex according to the present invention is lysine, histidine, arginine, aspartic acid, aspartic acid, threonine, serine, glutamic acid, proline , Glycine, alanine, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine and cysteine It may be composed of two or more amino acids. Preferably, the amino acid complex may be prepared by mixing the 17 amino acids in the same weight.

The cosmetic composition for skin whitening according to the present invention may include 0.5 to 1.5 parts by weight of jojoba seed oil and 0.07 to 0.27 parts by weight of the amino acid complex based on 100 parts by weight of the total cosmetic composition.

The amino acid complex according to the present invention is 0.005 to 0.015 parts by weight of lysine, 0.005 to 0.015 parts by weight of histidine, 0.005 to 0.015 parts by weight of arginine, 0.005 to 0.015 parts by weight of aspartic acid, threonine based on 100 parts by weight of the cosmetic composition for skin whitening 0.005 to 0.015 parts by weight, serine 0.005 to 0.015 parts, glutamic acid 0.005 to 0.015 parts, proline 0.005 to 0.015 parts, glycine 0.005 to 0.015 parts, alanine 0.005 to 0.015 parts, valine 0.005 to 0.015 parts, methionine 0.005 To 0.015 parts by weight, isoleucine 0.005 to 0.015 parts by weight, leucine 0.005 to 0.015 parts by weight, tyrosine 0.005 to 0.015 parts by weight, phenylalanine 0.005 to 0.015 parts by weight and cysteine 0.005 to 0.015 parts by weight.

In the present invention, it was confirmed that the use of a cosmetic composition mixed with jojoba seed oil and amino acid complex together with arbutin, niacinamide, aloe vera leaf extract, acerola extract, green tea extract, and broccoli extract, especially whitening effect and arbutin and niacin Experimentally proved to have a skin soothing effect that significantly reduces the skin irritation when containing only amide (see Experimental Example 1 and Experimental Example 2), comparing the skin soothing effect according to the content of each component to determine the optimum content range It confirmed (see Experimental Example 3).

The cosmetic composition for skin whitening according to the present invention is 4.0 to 6.0 parts by weight of arbutin, 1.0 to 3.0 parts by weight of niacinamide, 0.08 to 0.12 parts by weight of aloe vera leaf extract, and 0.08 to 0.12 parts of acerola extract based on 100 parts by weight of the cosmetic composition. Parts by weight, green tea leaf extract 0.08 to 0.12 parts by weight, broccoli extract 0.08 to 0.12 parts by weight, jojoba seed oil 0.8 to 1.2 parts by weight and amino acid complex 0.12 to 0.22 parts by weight.

The cosmetic composition for skin whitening according to the present invention is a cream, nourishing cream, moisturizing cream, hand cream, massage cream, nourishing lotion, moisturizing lotion, milk lotion, lotion, astringent, skin lotion, skin softener, skin toner, essence, nutrition It may be one or more formulations selected from the group consisting of essences, foundations, makeup bases, packs, patches, gels, powders, soaps, cleansing foams, cleansing lotions, cleansing creams, body lotions or body cleansers.

The cosmetic composition of the present invention, in the external composition of each formulation, other components than the essential components described above can be appropriately selected and blended by those skilled in the art without difficulty according to the formulation or purpose of use of other external preparations.

In addition, the cosmetic composition of the present invention may further include a skin protectant that can help the skin, such as skin moisturizer, skin softener, moisture blocker, in addition to the active ingredient, fatty substances, organic solvents, solubilizers, thickeners And gelling agents, emollients, softening agents, antioxidants, suspending agents, stabilizers, pH adjusting agents, blowing agents, fragrances, surfactants, water, emulsifiers, thickeners, fillers, metal ion sequestrants and chelating agents, preservatives, vitamins, blockers, It may contain adjuvants commonly used in the field of cosmetics such as wetting agents, essential oils, perfumes, dyes, pigments, hydrophilic or lipophilic actives, lipid vesicles or any other ingredients conventionally used in cosmetics. These adjuvants are introduced in amounts generally used in the cosmetic field.

Bouillon extract, Indian frankincense resin extract, squalane, hydrolyzed collagen, allantoin, capryl hydroxamic acid, hyaluronic acid, rosemary extract, high ginseng extract, tocopheryl acetate, D-panthenol, etc. It is available.

As the wetting agent, glycerin, butylene glycol, sodium hyaluronate, serine, sorbitol, mannitol, propylene glycol, ethylene glycol, cholesterol, cholesterol ester and the like can be used.

Examples of the emulsifier include glyceryl stearate, Fiji-40 stearate, sorbitan sesquioleate, polysorbate 60, glyce stearate / pig-100 stearate, and lipophilic glyceryl stearate.

Softeners include caprylic / capric triglycerides, cetearyl alcohol, cyclopentasiloxane, cetylethylhexanoate, cyclohexasiloxane, caprylyl glycol, trioctanoin, cetyloctanoate, stearic acid, Cyclomethicone, shea butter, lanolin, damethicone and the like can be used.

As the pH adjuster, triethanolamine, citric acid, sodium citrate, malic acid, sodium malate, fmaric acid, sodium fmarate, succinic acid, sodium succinate, sodium hydroxide, sodium dihydrogen phosphate and the like can be used.

Carbomer, hydroxyethyl acrylate / sodium acryloyl dimethyl thiurate copolymer, etc. can be used as a thickener, disodium dithiane can be used as a chelating agent, Purified water, 1,2-hexane as a solvent Diols and the like can be used.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it will be apparent to those skilled in the art that the scope of the present invention is not limited to these examples.

< Example  1> arbutin, Niacinamide  And plant extracts Cosmetics  Composition preparation

100 g of completely dried aloe vera leaves were pulverized and then extracted using a solvent extraction method using 1 L of 70% ethanol (EtOH) aqueous solution. In order to increase the efficiency during extraction, the extract was prepared by stirring for 48 hours using a stirrer. It was concentrated under reduced pressure at 50 ° C. or lower, and then lyophilized to obtain a powdery aloe vera leaf extract.

Acerola extract, green tea leaf extract and broccoli extract were obtained using the same method as above.

Obtained extract and arbutin and niacinamide to prepare a cosmetic composition (Example 1) in the composition of Table 1.

division Ingredient (Unit: wt%) Example 1 A Arbutin 5.00 Niacinamide 2.00 Aloe Vera Leaf Extract 0.10 Acerola extract 0.10 Green Tea Leaf Extract 0.10 Broccoli extract 0.10 B glycerin 5.00 Butylene Glycol 2.00 Caprylic / Capric Triglycerides 4.00 Cetearyl Alcohol 2.00 Cyclopentasiloxane 1.50 Cetylethylhexanoate 1.00 Glyceryl Stearate 2.00 Fiji-40 Stearate 1.00 C Spices a very small amount Purified water Remaining amount Sum 100.00

< Example  2> arbutin, Niacinamide Plant extracts, Jojoba  Preparation of cosmetic composition containing oil and amino acid complex

Amino acid complexes were prepared by mixing lysine, histidine, arginine, aspartic acid, threonine, serine, glutamic acid, proline glycine, alanine, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine and cysteine in equal weights.

The amino acid complex and jojoba seed oil, the extract obtained in Example 1, arbutin and niacinamide to prepare a cosmetic composition (Example 2) in the composition of Table 2.

division Ingredient (Unit: wt%) Example 2 A Arbutin 5.00 Niacinamide 2.00 Aloe Vera Leaf Extract 0.10 Acerola extract 0.10 Green Tea Leaf Extract 0.10 Broccoli extract 0.10 Jojoba seed oil 1.00 Amino acid complexes 0.17 B glycerin 5.00 Butylene Glycol 2.00 Caprylic / Capric Triglycerides 4.00 Cetearyl Alcohol 2.00 Cyclopentasiloxane 1.50 Cetylethylhexanoate 1.00 Glyceryl Stearate 2.00 Fiji-40 Stearate 1.00 C Spices a very small amount Purified water Remaining amount Sum 100.00

< Comparative example  1> Arbutin and Niacin Amide  contain Cosmetics  Composition preparation

The plant extract of Example 1 or Example 2, arbutin, niacinamide, jojoba seed oil and amino acid complexes to prepare a cosmetic composition (Comparative Examples 1 to 3) in the composition of Table 3.

division Ingredient (Unit: wt%) Comparative Example 1 Comparative Example 2 Comparative Example 3 A Arbutin 5.00 5.00 5.00 Niacinamide 2.00 2.00 2.00 Aloe Vera Leaf Extract - 0.10 - Acerola extract - 0.10 0.10 Green Tea Leaf Extract - - 0.10 Broccoli extract - - 0.10 Jojoba seed oil - 1.00 - Amino acid complexes - - 0.17 B glycerin 5.00 5.00 5.00 Butylene Glycol 2.00 2.00 2.00 Caprylic / Capric Triglycerides 4.00 4.00 4.00 Cetearyl Alcohol 2.00 2.00 2.00 Cyclopentasiloxane 1.50 1.50 1.50 Cetylethylhexanoate 1.00 1.00 1.00 Glyceryl Stearate 2.00 2.00 2.00 Fiji-40 Stearate 1.00 1.00 1.00 C Spices a very small amount a very small amount a very small amount Purified water Remaining amount Remaining amount Remaining amount Sum 100.00 100.00 100.00

< Experimental Example  1> Cosmetics  Analysis of whitening effect and skin irritation of composition

In order to confirm the whitening effect of the cosmetic compositions of Examples 1 and 2 and Comparative Examples 1 to 3, after inducing artificial pigmentation in women aged 19-22 years with healthy skin randomly selected 6 After the weekly use of the cosmetic composition was evaluated for the skin whitening effect and the presence of skin irritation.

Specifically, the skin whitening effects were evaluated before and after 1, 2, 4 and 6 weeks of use of the cosmetic composition. The evaluation criteria used a 1-7 point scale, 0 for 'no pigmentation', 1 for 'no or light pigmentation', 2 for 'light pigmentation', and 3 for 'light or normal pigmentation'. Point, 'normal pigmentation' is 4 points, 'normal or severe pigmentation' is 5 points, 'severe pigmentation' is 6 points, 'very severe pigmentation' is 7 points. The whitening effect of each cosmetic composition was evaluated by two observers at each time point, and the experimental results are expressed as the average score of 10 subjects in Tables 4 and 5 below. Table 4 shows the results of visual evaluation by observer 1, and Table 5 shows the results of visual evaluation by observer 2. The presence or absence of skin irritation was evaluated by (number of irritants) / (total number of test subjects).

division N Week 0 1 week 2 weeks 4 Weeks 6 Weeks Skin irritation Example 1 10 6.4 5.7 5.1 4.5 3.6 2/10 Example 2 10 6.5 5.5 5.0 4.4 3.1 0/10 Comparative Example 1 10 6.5 5.7 5.2 4.6 4.3 8/10 Comparative Example 2 10 6.4 5.8 5.2 4.6 4.2 6/10 Comparative Example 3 10 6.3 5.6 5.3 4.5 4.0 5/10

division N Week 0 1 week 2 weeks 4 Weeks 6 Weeks Skin irritation Example 1 10 6.5 5.4 5.1 4.3 3.2 2/10 Example 2 10 6.5 5.6 5.0 4.2 2.8 0/10 Comparative Example 1 10 6.6 5.7 5.2 4.5 4.2 8/10 Comparative Example 2 10 6.4 5.6 5.1 4.4 4.1 6/10 Comparative Example 3 10 6.4 5.7 5.1 4.4 4.0 5/10

As a result, the cosmetic compositions of Examples 1 and 2 were found to have a better whitening effect than the cosmetic compositions of Comparative Examples 1 to 3, and in particular, when using Example 2, it was confirmed that the best whitening effect appeared. .

In the case of using Comparative Examples 1 to 3, the whitening effect was also shown, but the use of cosmetics containing only arbutin and niacinamide (Comparative Example 1) showed a lot of skin irritation, and Comparative Examples 2 and 3 also used in Compared to Examples 1 and 2, the irritation was stronger and there was a fear of skin irritation for long-term use. However, the cosmetic composition (Examples 1 and 2) according to the present invention showed little skin irritation. From these results, it was confirmed that the cosmetic composition of Example 1 or 2 not only exhibits a whitening effect but also relieve skin irritation caused by arbutin and niacinamide.

< Experimental Example  2> Cosmetics  Analysis of skin soothing effect of the composition

After inducing skin stimulation through the tape stripping method on the inner part of the lower arm, targeting 10 men and women in their 20s and 30s who do not have any skin allergy symptoms, the cosmetics containing the complex fermented extract according to the present invention and Relative evaluation of the degree to which the irritation caused by the application of cosmetics containing no sedative was calmed. First, the skin erythema was induced by taping 30 times with regular Scotch tape on two inner parts of the lower arm. After the erythema was induced, the cosmetic compositions of Examples 1, 2 and Comparative Examples 1 to 3 were always applied, and the degree of skin soothing was evaluated 3 hours after the application.

The criterion was a scale of 1 to 5 points, 0 for 'no response', 1 for 'very mild erythema', 2 for 'slight or mild erythema', and 3 for 'clear but weak erythema'. The dot, 'clear erythema' is 4 points, and 'deep erythema' is 5 points. Experimental results are shown in Table 6 below the average score of 10 subjects.

division Skin irritation (erythema) degree Left Ooh Example 1 2.4 2.2 Example 2 0.2 0.3 Comparative Example 1 3.9 3.8 Comparative Example 2 3.3 3.4 Comparative Example 3 3.2 3.1

Arbutin, niacinamide, aloe vera leaf extract, acerola extract, green tea leaf extract, broccoli extract, jojoba seed oil and amino acid complexes of Example 2 according to the present invention as confirmed in Table 6 using In this case, it was confirmed that the skin soothing effect was superior to that of Example 1 or the comparative example.

< Experimental Example  3> Cosmetics  Analysis of skin soothing effect according to the content of each ingredient in the composition

For the cosmetic composition of Example 2 having the best skin whitening and skin soothing effect, aloe vera leaf extract, acerola extract, green tea leaf extract, broccoli extract, jojoba seed oil and By varying the content of the amino acid complex was prepared in the cosmetic composition of Examples 3 to 26 with the composition of Table 7 to Table 12, the skin sedation effect of each cosmetic composition was evaluated in the same manner as in Experiment 2. At this time, the content of the components other than the above components were mixed in the same manner as in Example 2.

(unit:
weight%) Arbutin
Niacinamide
Aloe Vera Leaf Extract Acerola extract
Green tea extract
Broccoli extract
Jojoba seed oil
Amino acid complexes
Skin irritation
(Erythema) degree Left Ooh Example 3 5.00 2.00 0.05 0.10 0.10 0.10 1.00 0.17 2.8 2.9 Example 4 5.00 2.00 0.08 0.10 0.10 0.10 1.00 0.17 0.4 0.5 Example 2 5.00 2.00 0.10 0.10 0.10 0.10 1.00 0.17 0.2 0.3 Example 5 5.00 2.00 0.12 0.10 0.10 0.10 1.00 0.17 0.5 0.4 Example 6 5.00 2.00 0.15 0.10 0.10 0.10 1.00 0.17 2.7 2.6

(unit:
weight%) Arbutin
Niacinamide
Aloe Vera Leaf Extract Acerola extract
Green tea extract
Broccoli extract
Jojoba seed oil
Amino acid complexes
Skin irritation
(Erythema) degree Left Ooh Example 7 5.00 2.00 0.10 0.05 0.10 0.10 1.00 0.17 2.9 3.0 Example 8 5.00 2.00 0.10 0.08 0.10 0.10 1.00 0.17 0.4 0.6 Example 2 5.00 2.00 0.10 0.10 0.10 0.10 1.00 0.17 0.2 0.3 Example 9 5.00 2.00 0.10 0.12 0.10 0.10 1.00 0.17 0.6 0.5 Example 10 5.00 2.00 0.10 0.15 0.10 0.10 1.00 0.17 2.8 2.7

(unit:
weight%) Arbutin
Niacinamide
Aloe Vera Leaf Extract Acerola extract
Green tea extract
Broccoli extract
Jojoba seed oil
Amino acid complexes
Skin irritation
(Erythema) degree Left Ooh Example 11 5.00 2.00 0.10 0.10 0.05 0.10 1.00 0.17 2.7 2.9 Example 12 5.00 2.00 0.10 0.10 0.08 0.10 1.00 0.17 0.4 0.5 Example 2 5.00 2.00 0.10 0.10 0.10 0.10 1.00 0.17 0.2 0.3 Example 13 5.00 2.00 0.10 0.10 0.12 0.10 1.00 0.17 0.5 0.5 Example 14 5.00 2.00 0.10 0.10 0.15 0.10 1.00 0.17 2.8 2.8

(unit:
weight%) Arbutin
Niacinamide
Aloe Vera Leaf Extract Acerola extract
Green tea extract
Broccoli extract
Jojoba seed oil
Amino acid complexes
Skin irritation
(Erythema) degree Left Ooh Example 15 5.00 2.00 0.10 0.10 0.10 0.05 1.00 0.17 2.8 2.7 Example 16 5.00 2.00 0.10 0.10 0.10 0.08 1.00 0.17 0.6 0.5 Example 2 5.00 2.00 0.10 0.10 0.10 0.10 1.00 0.17 0.2 0.3 Example 17 5.00 2.00 0.10 0.10 0.10 0.12 1.00 0.17 0.3 0.4 Example 18 5.00 2.00 0.10 0.10 0.10 0.15 1.00 0.17 2.8 2.9

(unit:
weight%) Arbutin
Niacinamide
Aloe Vera Leaf Extract Acerola extract
Green tea extract
Broccoli extract
Jojoba seed oil
Amino acid complexes
Skin irritation
(Erythema) degree Left Ooh Example 19 5.00 2.00 0.10 0.10 0.10 0.10 0.50 0.17 3.1 3.0 Example 20 5.00 2.00 0.10 0.10 0.10 0.10 0.80 0.17 0.5 0.4 Example 2 5.00 2.00 0.10 0.10 0.10 0.10 1.00 0.17 0.2 0.3 Example 21 5.00 2.00 0.10 0.10 0.10 0.10 1.20 0.17 0.6 0.7 Example 22 5.00 2.00 0.10 0.10 0.10 0.10 1.50 0.17 2.7 2.8

(unit:
weight%) Arbutin
Niacinamide
Aloe Vera Leaf Extract Acerola extract
Green tea extract
Broccoli extract
Jojoba seed oil
Amino acid complexes
Skin irritation
(Erythema) degree Left Ooh Example 23 5.00 2.00 0.10 0.10 0.10 0.10 1.00 0.07 2.9 3.0 Example 24 5.00 2.00 0.10 0.10 0.10 0.10 1.00 0.12 0.3 0.4 Example 2 5.00 2.00 0.10 0.10 0.10 0.10 1.00 0.17 0.2 0.3 Example 25 5.00 2.00 0.10 0.10 0.10 0.10 1.00 0.22 0.5 0.6 Example 26 5.00 2.00 0.10 0.10 0.10 0.10 1.00 0.27 2.8 3.0

As a result, based on the total weight of the cosmetic composition, 0.08 to 0.12% by weight of aloe vera leaf extract, 0.08 to 0.12% by weight of acerola extract, 0.08 to 0.12% by weight of green tea extract, 0.08 to 0.12% by weight of broccoli extract, 0.80 to 1.20 Skin sedative effect appeared in the cosmetic composition comprising the content in the range of 0.1% to 0.22% by weight and amino acid complex, in particular, aloe vera leaf extract 0.10% by weight, acerola extract 0.10% by weight, green tea extract 0.10% by weight, broccoli extract It was confirmed that the skin soothing effect of the cosmetic composition including 0.10% by weight, jojoba seed oil 1.00% by weight and amino acid complex 0.17% by weight was the best.

So far I looked at the center of the preferred embodiment for the present invention. Those skilled in the art will appreciate that the present invention can be implemented in a modified form without departing from the essential features of the present invention. Therefore, the disclosed embodiments should be considered in descriptive sense only and not for purposes of limitation. The scope of the present invention is shown in the claims rather than the foregoing description, and all differences within the scope will be construed as being included in the present invention.

Claims (8)

Albutin, niacinamide, Aloe barbadensis leaf extract, Alpella (Malpighia emarginata fruit) extract, Green tea (Camellia sinensis leaf extract), Broccoli (Brassica oleracea var. Italica) extract, Jojoba seed oil In the cosmetic composition for skin whitening comprising (Simmondsia chinensis seed oil) and amino acid complex,
The amino acid complex is lysine, histidine, arginine, arginine, aspartic acid, threonine, threonine, serine, glutamic acid, proline, glycine ), Alanine, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine and cysteine,
Based on the total 100 parts by weight of the cosmetic composition for skin whitening, 5 parts by weight of arbutin, 2 parts by weight of niacinamide, 0.08-0.12 parts by weight of aloe vera leaf extract, 0.08-0.12 parts by weight of acerola extract, 0.08-0.12 parts by weight of green tea extract, Broccoli extract is characterized in that it comprises 0.08-0.12 parts by weight, jojoba seed oil 0.8-1.2 parts by weight and 0.12-0.22 parts by weight of the amino acid complex,
Cosmetic composition for skin whitening. The method of claim 1,
Each component constituting the amino acid complex is a cosmetic composition for skin whitening, characterized in that included in the same amount. delete delete delete delete delete The method of claim 1,
The cosmetic composition for skin whitening is cream, nourishing cream, moisturizing cream, hand cream, massage cream, nourishing lotion, moisturizing lotion, milk lotion, lotion, astringent, skin lotion, skin softener, skin toner, essence, nutrition essence, foundation, Makeup base, pack, gel, powder, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion or body cleanser is a formulation selected from the group consisting of skin whitening.