KR20220051970A - A vitamin composition for cosmetic material encapsulated nano liposome and cosmetic composition using thereof - Google Patents

Abstract

A composition of ascorbic acid (vitamin C) for a cosmetic product according to the present invention can exhibit excellent antioxidant activity by completely blocking contact with external oxidation-inducing factors using nanoliposomes, wherein the nanoliposomes is formed of natural emulsifiers and capture the ingredients of the composition. In addition, the extracts themselves have excellent beauty benefits such as whitening, moisturizing, wrinkle improvement, and anti-aging, thus has a synergistic effect with vitamin C, and thereby being able to prevent the skin from aging.

Description

A vitamin composition for cosmetic encapsulated in nano liposomes and a cosmetic composition comprising the same

The present invention relates to a cosmetic vitamin composition encapsulated in nano liposomes and a cosmetic composition comprising the same, and in particular, a cosmetic vitamin composition that further improves formulation stability and vitamin efficacy by collecting active ingredients in nano liposomes formed from a natural emulsifier. And it relates to a cosmetic composition comprising the same.

There are many theories to explain skin aging, but among them, the free radical theory that the skin ages by free radicals generated by various causes outside the body is accepted as the most valid theory.

Free radicals are highly chemically reactive chemicals that are generated when the skin is irradiated with ultraviolet rays or in the process of respiration of cells in the skin. Most of the free radicals related to skin aging are Reactive Oxygen Species (ROS). and singlet oxygen.

The goal of antioxidant cosmetics is to maintain healthy skin, and also to delay the aging of the skin that occurs naturally with age. For this purpose, research to develop substances with excellent safety and excellent skin-beauty effects by searching the skin physiological activity of various natural plant components is currently being actively conducted.

On the other hand, the skin functions as a protective film against harmful substances or harmful effects, but on the other hand, it also functions as a barrier against effective substances. Therefore, a special skin absorption and delivery system is required to selectively penetrate the active substance into the skin, and one of the most studied for this purpose is a liposome.

Liposomes are vesicles formed when phospholipids are suspended in aqueous solution, and are isolated from the outer membrane by a membrane composed of lipid bilayers, and lipids such as cholesterol glycolipids or membrane proteins can be introduced into the membrane.

Liposomes can trap aqueous solutions or oil-soluble substances, and thus serve to help transport these raw materials. For example, when sensitive and difficult-to-absorb raw materials are captured and transported in liposomes, these raw materials play a role in helping them to be absorbed into the skin without being broken.

An antioxidant that helps the antioxidant of the skin may include vitamin C. Vitamin C is known to have various physiological functions, such as acting as an enzymatic co-factor of enzymes in the living body, and acting as an antioxidant. In particular, it is known that using a large amount of vitamin C has a whitening effect and an anti-aging effect on the skin. When vitamin C is used in high doses, it reacts with superoxide and hydroxyl radicals. Superoxide and hydroxyl radical are active oxygen containing oxygen, which can be generated under normal or diseased conditions, and act as causative agents in the case of skin tanned by UV rays or skin aging.

However, vitamin C has a double bond between carbon 2 and carbon 3 and has hydrogen (pK = 4.2) that can undergo acid-ionization in the presence of water. It becomes an unstable anionic compound under high Oxidative decomposition by oxidative decomposition and decomposition by water attack are thought to be the cause.

Therefore, various methods have been considered to stabilize this unstable vitamin C. Conventional methods include a method using an extremely low concentration of vitamin C, a method using a non-aqueous solvent, or a method using several derivatives of vitamin C. However, there is a problem that the stabilization effect is insufficient, and the skin whitening effect of the vitamin C derivative is inferior.

Republic of Korea Patent Publication No. 10-2010-0049155 (May 20, 2010)

The present invention has been devised to solve the above problems, and in detail, by capturing the active ingredient containing vitamin C in nano liposomes formed from a natural emulsifier, the formulation stability of vitamin C is increased and cosmetic effects such as skin whitening An object of the present invention is to provide a vitamin composition for cosmetics with increased

Another object of the present invention is to provide a cosmetic composition comprising the cosmetic vitamin composition.

The present invention relates to a cosmetic vitamin composition encapsulated in nano liposomes and a cosmetic vitamin comprising the same.

One aspect of the present invention is a natural emulsifier comprising any one or a plurality of fatty acids selected from lecithin, hydrogenated lecithin, palmitic acid, stearic acid, oleic acid, linoleic acid and linolenic acid; vitamin A, vitamin B, vitamin C, vitamin any one or a plurality of vitamins selected from D, vitamin E and vitamin K; Any one or a plurality of stabilizers selected from potassium hydroxide, sodium hydroxide and triethanolamine; And aroma oil; relates to a vitamin composition for cosmetics encapsulated in nano liposomes, characterized in that it comprises.

In the present invention, the aroma oil is jojoba oil, avocado oil, almond oil, olive oil, sesame oil, wheat germ oil, safflower oil, camellia oil, castor oil, grape seed oil, green tea seed oil, macadamia nut oil, palm oil, rosehip oil , hydrogenated oil, argan oil, sea buckthorn oil, argan tree kernel oil and lavender oil, characterized in that it contains any one or a plurality of selected.

In addition, the composition is characterized in that it comprises 1 to 30% by weight of a natural emulsifier, 1 to 30% by weight of vitamins, 1 to 10% by weight of a stabilizer, and 50 to 70% by weight of an aromatic oil.

Another aspect of the present invention relates to a cosmetic composition comprising the cosmetic vitamin composition, wherein the cosmetic composition comprises 0.1 to 90% by weight of the cosmetic vitamin composition in 100% by weight of the total total weight.

In addition, the cosmetic composition includes softening lotion, astringent lotion, nourishing lotion, nourishing cream, massage cream, eye cream, serum, cleansing cream, cleansing foam, cleansing water, pack, body lotion, body cream, body oil, body essence, makeup base. , foundation, and may have any one or a plurality of formulations selected from the group consisting of body wash.

The vitamin C composition for cosmetics according to the present invention can express excellent antioxidant power by completely blocking contact with external oxidation-inducing factors as nanoliposomes formed from natural emulsifiers capture the components. In addition, the extracts themselves are very excellent in cosmetic effects such as whitening, moisturizing, wrinkle improvement, and anti-aging, so that they can synergize with vitamin C to prevent skin aging.

Hereinafter, for example and comparative examples, a cosmetic vitamin composition encapsulated in nano liposomes according to the present invention and a cosmetic composition comprising the same will be described in more detail. However, the embodiments introduced below are provided as examples so that the spirit of the present invention can be sufficiently conveyed to those skilled in the art.

Therefore, the present invention is not limited to the embodiments presented below and may be embodied in other forms, and the embodiments presented below are merely described to clarify the spirit of the present invention, and the present invention is not limited thereto.

At this time, unless there are other definitions in the technical terms and scientific terms used, it has a meaning commonly understood by a person of ordinary skill in the art to which this invention belongs, and in the following description, it may unnecessarily obscure the subject matter of the present invention. A description of possible known functions and configurations will be omitted.

Also, the singular forms used in the specification and appended claims may also be intended to include the plural forms unless the context specifically dictates otherwise.

In the present invention, the term 'cosmetics' is an article that is not intended to directly improve the skin, but is used in a way to clean or beautify the human body, such as shaving, spraying or other similar methods, for example, a softening lotion, astringent lotion, Includes products such as nourishing lotion, nourishing cream, massage cream, eye cream, serum, cleansing cream, cleansing foam, cleansing water, pack, body lotion, body cream, body oil, body essence, makeup base, foundation, and body cleanser. do.

As used herein, the term 'extract' refers to a liquid component obtained by immersing a target substance in various solvents and then extracting it for a certain time at room temperature or in a heated state, and a solid obtained by removing the solvent from the liquid component. it means. In addition, in addition to the result, it can be comprehensively interpreted as including all of the dilutions of the results, their concentrates, their preparations, and their purified products. Accordingly, the fermented ginger extract provided in the present invention is an extract obtained by extracting fermented ginger, a diluted or concentrated solution of the extract, a dried product obtained by drying the extract, a prepared or purified product of the extract, or a mixture thereof, etc. , it can be interpreted to include extracts of all formulations that can be formed using the extract itself and the extract.

In the present invention, the term 'liposome' refers to a spherical biosimilar lipid membrane made by spontaneous formation of phospholipids in an aqueous solution, and a hydrophilic substance can be loaded inside the membrane due to the phospholipid bilayer structure, and a hydrophobic substance can be loaded between the bilayers. can

The vitamin composition for cosmetics according to the present invention is based on a vitamin component, and may include a natural substance capable of preventing oxidation of the vitamin component, a natural emulsifier, a stabilizer, and a polyol preventing their precipitation.

In the present invention, the vitamin component is an oxidizing material, particularly to inhibit the activity of free radicals that act as a cause of skin aging. Vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, vitamins It may contain K.

The vitamin A is also called retinol (retinol), mainly maintains the humidity of the skin, and plays an important function in maintaining the function of epithelial cells and maintaining the immune system.

The vitamin B refers to a vitamin B complex, which refers to a complex of several water-soluble vitamins, and mainly serves as a coenzyme that helps the metabolism of cells. In general, as described above, it is estimated that there is only one form of substance that acts as a coenzyme of metabolism, so it was named vitamin B. did

In this case, the vitamin B may include B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folinic acid), B12 (cobalamin), etc. In addition, B4 (choline), B8 (inositol, etc.), B10 (paraaminobenzoic acid), B11 (folic acid), B13 (orotic acid), B16 (dimethylglycine), Bf (carnitine), etc. may be further included. .

The vitamin C, also called ascorbic acid, is the most powerful and broad-spectrum antioxidant among antioxidant vitamins in cells and plays an important antioxidant action in the lens and plasma.

The vitamin D is also called calciferol (calciferol), and can only be synthesized in the body when sterols in the skin receive ultraviolet rays. The calciferol inhibits cell proliferation and induces normal keratinization, thereby preventing abnormal hyperkeratosis and alleviating wrinkles.

The vitamin E, also called tocopherol, is a powerful fat-soluble vitamin that blocks the chain reaction of free radicals while present in the mitochondrial membrane. It is known to prevent tissue damage by replacing the cell membrane damage caused by free radicals. It interacts with C and plays an important role as an antioxidant.

The vitamin K has a quinone structure, and may be divided into phylloquinone (K1) and menaquinone (menaquinone) depending on the molecular structure of the vitamin K. These are fat-soluble vitamins, and deficiency can cause bone loss, difficulty in hemostasis, and even bleeding.

In the present invention, the vitamin is more preferably vitamin C. The vitamin C has a strong antioxidant effect, and not only suppresses free radicals, but also promotes collagen synthesis.

In general, an enzyme that synthesizes collagen functions as an active enzyme when it is bound to iron in a divalent state, and loses activity when iron is oxidized to a trivalent state. The vitamin C serves as a coenzyme to help collagen synthesis because the component of the enzyme has a function of maintaining the SH group in the reduced state by reducing the iron in the trivalent state to the divalent state.

In addition, it acts to inhibit melanin deposition. That is, the vitamin C is a powerful antioxidant that has an antioxidant effect on the skin surface that biochemically affects the skin, an effect of promoting collagen synthesis in the dermis to give elasticity to the skin, and inhibition of melamine pigment between the epidermis and the dermis. It has a whitening effect through

In the present invention, it is preferable to add 1 to 30% by weight of the vitamin in 100% by weight of the total composition. If the content of the vitamin is less than the above range, it is difficult to secure the effect of whitening, wrinkle improvement, and antioxidant according to the addition of the vitamin. Side effects such as irritation, allergy, and inflammation may occur on the skin.

The emulsifier is a basic component of liposomes, and consists of phospholipids and fatty acids. As described above, the phospholipid components exhibiting hydrophilicity are exposed to the outside of the liposome because they have hydrophilicity and lipophilicity at the same time, and the lipophilic fatty acids are the walls of the liposome. It has a structure that fills the inside.

In the present invention, as the phospholipid, for example, lecithin, hydrogenated lecithin, phosphatidylcholine, lysophosphatidylcholine, phosphatidylethanolamine, palmitic acid, hydrogenated phosphatidylcholine phophatidylcholine - derived from soy), phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, and the like, and these may be used alone or two or more. Among them, hydrogenated phosphatidylcholine is more preferable as a cosmetic raw material requiring long-term stability because it has excellent oxidation stability and decolorization and deodorization effects compared to phosphatidylcholine containing unsaturated fatty acids.

Examples of the fatty acid include stearic acid, oleic acid, linoleic acid, linolenic acid (soybean-derived), etc., in addition to cetearyl olivate, sorbate It may further include sobitan olivate (olive-derived) and the like. The above components may be used alone or in combination of two or more.

Two or more kinds of the emulsifier may be mixed and used. For example, as the first emulsifier, phosphatidylcholine, lysophosphatidylcholine, phosphatidylethanolamine, palmitic acid, stearic acid, oleic acid, linoleic acid acid), a composition of linolenic acid (soybean-derived), as the second emulsifier, hydrogenated phosphatidylcholine (soybean-derived) may be used.

In the present invention, the emulsifier preferably contains 1 to 30% by weight of 100% by weight of the total composition. When the emulsifier is added below the above range, it is difficult to encapsulate the nano-liposomes because they are not synthesized properly. When the amount exceeds 30% by weight, the amount of the active ingredient is reduced, and the nano-liposomes are generated in large amounts, so phase separation may occur during the preparation of the cosmetic composition.

In the present invention, the stabilizer is intended to further increase stability by neutralizing hydrogen ions generated during ionization of vitamins or derivatives, and exhibits an effect of inhibiting crystal precipitation and oxidation of vitamins or derivatives while lowering the pH of the composition. can

In the present invention, the stabilizer includes, for example, potassium hydroxide, sodium hydroxide and triethanolamine, and these may be used alone or in combination of two or more.

More preferably, potassium hydroxide is mentioned as the said stabilizer. The potassium hydroxide is preferable because it can further enhance the stabilization effect by further strengthening the bond between the vitamin and the solvent or the ascorbic acid derivative to be described later.

The stabilizer is preferably included in an amount of 1 to 10% by weight based on 100% by weight of the total composition. When the stabilizer is added below the above range, precipitation of vitamins may occur during the preparation of the composition, and when the stabilizer is added in excess of the above range, the oxidation stability of the vitamin may decrease and rancidity of the composition may occur.

In the present invention, the aromatic oil is a component that expresses the fragrance of the composition, and by itself, it helps to dissolve active ingredients such as emulsifiers and can suppress the problem that vitamins or derivatives thereof may be decomposed before being stabilized in the composition. .

For example, jojoba oil, avocado oil, almond oil, olive oil, sesame oil, wheat germ oil, safflower oil, camellia oil, castor oil, grape seed oil, green tea seed oil, macadamia nut oil, palm oil, rose hip There are oil, hydrogenated oil, argan oil, hawthorn oil, argan tree kernel oil and lavender oil, and these may be used alone or in combination of two or more.

In the present invention, the aromatic oil preferably contains 50 to 70% by weight of 100% by weight of the composition. When added below the above range, phase separation of the composition may occur, and when it exceeds the above range, skin improvement effects such as whitening are not properly expressed due to a decrease in the amount of active ingredient added.

In the present invention, the cosmetic vitamin composition is not limited to a manufacturing method. For example, after mixing the natural ingredients, the stabilizer, and the solvent, it may be bathed in a water bath at a temperature of 50 to 100° C. for 1 to 30 minutes. In this case, it is preferable to stir at a speed of 10 to 100 rpm for more uniform mixing during the bathing process. After the mixture is cooled to room temperature (20℃), vitamins can be added to prevent the destruction of vitamins due to high temperature.

Separately, in order to generate nano-liposomes, one or more emulsifiers described above are mixed with a part of distilled water and then ultrasonically disrupted at 50 to 80° C. using an ultrasonic crusher (Ultrasonic Liquid Processor). Ultrasonic crushing is an operation to homogenize the mixture. When the emulsifier is homogenized, a collecting material containing natural ingredients is added, and then ultrasonically crushed to mix. When the emulsifier and the collecting material are completely homogenized, it is mixed with the remaining distilled water heated to 40 to 60° C. and mixed through ultrasonic crushing to form liposome-shaped particles. Thereafter, the temperature is gradually lowered and finally ultrasonically disrupted for 5 minutes to make the particles smaller and more uniform, thereby preparing liposomes encapsulating nano-sized active ingredients.

The present invention relates to a cosmetic composition comprising the above cosmetic vitamin composition. In this case, the cosmetic composition may be divided into an oil layer composition and an aqueous layer composition according to the formulation.

In the present invention, the oil layer composition includes a component that is not soluble in a solvent such as water and a surfactant for dissolving it, and may include an amphiphilic lipid, a triglyceride, a fat, and the like.

In the present invention, the amphiphilic lipid refers to a molecule that is mostly a lipid-like (hydrophobic) molecule in structure, but has a polar, charged, or a combination of polarity and charge (hydrophilic) moiety at one end. The hydrophilic moiety may then be referred to as the head group and the lipid moiety may be referred to as the tail group.

The amphiphilic lipid may form crystals according to the ambient temperature, uniformly and stably form a high-density lipid network similar to the skin, and may have a cholesteric liquid crystal phase.

The cholesteric liquid crystal phase as described above is arranged in layers while a director of a nematic liquid crystal is twisted along a spiral axis, and is rotated at a predetermined angle for each layer. By having such a structure, the moisturizing effect of the existing amphiphilic lipids is maintained, and at the same time, it has a polarization pattern due to the birefringence of light, so that it can give an aesthetic feeling to the consumer and further improve the quality of cosmetics.

Examples of the amphiphilic lipids include, in addition to phospholipids, glycolipids and sphingolipids, which are the main components of the skin keratin, uniformly and stably forming a high-density lipid network having a skin-like film, and in addition to liquid crystal formation, contain a hydrophilic active material in the liquid crystal to stabilize it. material may be included.

Materials such as polyethylene glycol ester surfactants or sorbitan fatty ester surfactants may be used as the amphiphilic lipids as described above, and preferably glyceryl monostearate, glyceryl monoisostearate, cetyl alcohol , stearyl alcohol, cetostearyl alcohol, behenyl alcohol, batyl alcohol, phytantriol, glyceryl distearate, glyceryl diisostearate, pentaerythrityl distearate, pentaerythrityl diisostearate, pentaerythryl alcohol Erythrityl tetrastearate, pentaerythrityl tetraisostearate, coleth-5, coleth-10, coleth-20, coleth-30, deoxyphytantriyl palmitamide MEA, diethoxyethyl stone Cinate, bis-ethoxydiglycol succinate, dipalmitoylhydroxystearate, cocoylalanine, palmitoylproline, galatosylceramide, hydrogenated lecithin, polyglyceryl-10 diisostearate, polyglyceryl- 10 It may be any one or two or more selected from triisostearate, polyglyceryl-2 stearate, polyglyceryl-2 distearate, polyglyceryl-6 distearate and polyglyceryl-6 diisostearate Among them, it is preferable to use PEG (polyethylene glycol)-40 stearate, PEG-100 stearate, sorbitan stearate, glyceryl stearate, etc. in terms of oxidation stability and suppression of skin side effects.

The triglyceride is a major component constituting the epidermis, and when applied to the composition, repairs the surface of the wounded skin, serves as a moisturizing agent to supply moisture, and can be used as a solvent for the oil layer composition.

Examples of the triglycerides, (C8-C12) acid triglyceride, (C12-C18) acid triglyceride, caprylic / capric / triglyceride, caprylic / capric / lauric triglyceride, (C10 -C20 isoalkyl acid triglyceride, (C10-C18) triglyceride, glyceryl triacetyl hydrostearate, soybean glyceride, tribehenin, tricaprine, triethylhexanoyl, triheptanoin, triisostearin, Tripalmitin and tristearin may be mentioned, and these may be used alone or in combination of two or more.

The oil is a major component constituting the epidermis of the skin, similar to the triglyceride, and serves to prevent evaporation of moisture to maintain moisturizing power.

Examples of the above fats and oils include ascorbyl palmitate, ascorbilinolate, ascorbyl stearate, distearyl malate, benzyl benzoate, benzyl laurate, butylene glycol dicaprylate/dicaprate, butylene glycol diisono Nanoate, butylene glycol laurate, butylene glycol stearate, butyl isostearate, cetearylisononanoaine, cetearylnonanoate, cetylcaprylate, cetylethylhexanoate, cetylisono Nanoate, ethylhexyl caprylate/caprate, ethylhexylisononanoate, ethylhexylisostearate, ethylhexyllaurate, hexyllaurate, octyldodecylisostearate, isopropylisostearate, Isostearyl isononanoate, isostearyl isostearate, isocetylethyl hexanoate, neopentyl glycol dicaprate, neopentyl glycol diethyl hexanoate, neopentyl glycol diisononanoate, neopentyl glycol di There are isostearate, pentaerythrityl stearate, pentaerythrityltetraethylhexanoate, triethylhexanoin, and the like, and these may be used alone or in combination of two or more.

In the present invention, the amount of each component added is not limited in the oil layer composition, and it can be freely adjusted according to the formulation of the composition within a range that does not impair the purpose of the present invention.

In addition to the oil phase composition according to the present invention, cyclopentasiloxane, cyclohexasiloxane, cycloheptasiloxane, cyclomethicone, cyclophenylmethicone, cyclotetrasiloxane, cyclotrisiloxane, dimethicone, caprylyldimethicone, caprylyltri Methicone, caprylyl methicone, cetearyl methicone, hexadecyl methicone, hexyl methicone, lauryl methicone, myrisyl methicone, ethyl methicone, stearyl methicone, skearyl dimethicone, trifluoroflo Silicone oils such as pilmethicone, cetyldimethicone, dimethylpolysiloxane, methylphenylpolysiloxane, decamethylcyclopentasiloxane, methylctrimethicone, and phenyltrimethicone may be further added, and the present invention relates to the addition amount thereof and alone/mixed It does not limit whether to use or not.

In the present invention, the aqueous layer composition is for dissolving the water-soluble component of the composition and storing moisture to be delivered to the skin, and may include a polyol, an emulsifier, a conditioner, an emollient, etc. together with the cosmetic vitamin composition.

In the present invention, the polyol acts as a solvent or antioxidant of a water-soluble component. may include

Such emulsifiers include salts of fatty acids (eg sodium stearate or sodium palmitate, organic soaps (eg mono-, di- or triethanolaminoleate), sulfurized or sulfonated compounds (eg sodium lauryl sulfate or sodium cetyl) anionic compounds such as sulfonates), saponins, ramefones; cationic compounds such as quaternary ammonium salts; nonionic compounds such as fatty alcohols, fatty acid esters with saturated or unsaturated fatty acids, polyoxyethylene esters of fatty acids or polyoxyethylene ethers, polymers from ethylene oxide and propylene oxide or propylene glycol), amphoteric compounds such as phosphatides, proteins such as gelatin, casein, alkylamidobetaines, alkyl betaines and amphoglycans cinate), alkyl phosphates, alkylpolyoxyethylene phosphates or corresponding acids, silicone derivatives such as alkyl dimethiconecopliol.

The conditioner includes alkylamido ammonium lactate, cetrimonium chloride and distearoylethyl hydroxyethylmonium methosulfate and cetearyl alcohol, cetyl dimethicone, cetyl ricinoleate, dimethicone, laureth-23, Laureth-4, polydecene, retinyl palmitate, quaternized protein hydrolyzate, quaternized cellulose and starch derivatives, quaternized copolymers of acrylic acid or methacrylic acid or salts, and quaternized silicone derivatives are mentioned.

The emollients include cetearyl isononanoate, cetearyl octanoate, decyl oleate, isooctyl stearate, coco caprylate/caprate, ethylhexyl hydroxystearate, ethylhexyl isononanoate, Isopropyl isostearate, isopropyl myristate, oleyl oleate, hexyl laurate, paraffinum liquidum, PEG-75 lanolin, PEG-7 glyceryl cocoate, petrolatum, ozokerite cyclomethicone, dimethicone , dimethicone copolyol, dicaprylyl ether, butyrospermumparki, buxus kinensis, canola, carnauba sera, copernicia serifera, oenotera biennis, elaes ginensis, prunus dulcis, squalane, zea may, glycine soya, helianthus annus, lanolin, hydrogenated castor oil, hydrogenated polyisobutene, sucrose cocoate, stearic dimethicone, lanolin alcohol, isohexadecane, and the like.

In the present invention, the aqueous layer composition, like the oil phase composition, does not limit the addition amount of each component, and can be freely adjusted according to the formulation of the composition within a range that does not impair the purpose of the present invention. In addition, the composition ratio of the aqueous layer composition and the oil phase composition is not limited, but is preferably mixed in a weight ratio of 1:1.

However, it is preferable to adjust the content of the cosmetic vitamin composition in order to control the active ingredient content and suppress side effects in the cosmetic composition, and specifically, the cosmetic composition contains the cosmetic vitamin composition in an amount of 0.1 to 100% by weight of the total total weight. It is preferable to include 90% by weight.

In addition, the composition may include various active ingredients depending on the application site of the skin. Examples of such active ingredients include antimicrobial agents, anti-inflammatory agents, plant extracts, bisabolol, panthenol, tocopherol, anti-bite, anti-irritant or anti-dandruff actives, or anti-aging agents (such as retinol and melibiose) may contain Other suitable active agents are, for example, Medicago officinalis, Actinidia chinensis, allantoin, Aloe barbadensis, Anona cherimolia. , Anthemis nobilis, Arachis hypogaea, Arnica Montana, Avena sativa, Beta-carotene, Bisabolol, Borago officinalis officinalis), butylene glycol, Calendula officinalis, Camellia sinensis, camphor, Candida bombicola, capryloyl glycine, Carica papaya, Centaurea cyanus, cetylpyridinium chloride, Chamomilla recutita, Chenopodium quinoa, Chinchona succirubra, Chondrus crispus), Citrus aurantium dulcis, Citrus grandis, Citrus limonum, Cocos nucifera, Coffea Arabica, Crataegus monogina, Cucumis melo, dichlorophenyl imidazoledioxolane, Enteromorpha compressa, Equisetum arvense, ethoxydiglycol, ethyl panthenol , farnesol, ferulic acid, fragaria chiloensis, gentiana lutea, gingko biloba (G inkgo biloba), glycerin, glyceryl laurate, Glycyrrhiza glabra, Hamamelis virginiana, heliotropin, hydrogenated palm glyceride, citrate, hydrolyzed castor oil, hydrous digested wheat protein, Hypericum perforatum, Iris florentina, Juniperus communis, Lactis proteinum, Lactose, Rausonia iner Miss (Lawsonia inermis), linalool, linum usitatissimum (Linum usitatissimum), ricin, magnesium aspartate, magnifera indica, malva sylvestris, mannitol, mel melareuca al Ternifolia (mel Melaleuca alternifolia), Mentha piperita, Menthol, Methyl Lactate, Mimosa tenuiflora, Nymphaea alba, Olaflur, Oryza sativa (Oryza) sativa), Panthenol, Paraffinum Liquidum, PEG-20M, PEG-26 Jojoba Acid, PEG-26 Jojoba Alcohol, PEG-35 Castor Oil, PEG-40 Hydrogenated Castor Oil, PEG-60 Hydrogenated Castor Oil, PEG-8 Carbide Pril/capric acid, Persea gratissima, petrolatum, potassium aspartate, potassium sorbate, propylene glycol, Prunus amygdalus dulcis, Prunus armeniaca ), Prunus persica, Retinyl Palmitate, Ricinus communis, Rosa canina, Rosmarinus officinalis, Rubus daeus idaeus), salicylic acid, Sambucus nigra, sarcosine, Serenoa serrulata, Simmondsia chinensis, sodium carboxymethyl betaglucan, sodium cocoyl amino acid, sodium hyaluronic acid Ronate, sodium palmitoyl praline, stearoxytrimethylsilane, stearyl alcohol, sulfide TEA-ricinoleate, talc, Thymus vulgaris, Tilia cordata, tocopherol, tocopheryl acetate, tri deceth-9, Triticum vulgare, tyrosine, undecylenoyl glycine, urea, Vaccinium myrtillus, valine, zinc oxide, zinc sulfate, and the like.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples. However, the following examples and comparative examples are only examples for explaining the present invention in detail, and the present invention is not limited by the following examples.

The physical properties of the specimens prepared in the following Examples and Comparative Examples were tested as follows.

(Formulation stability)

Immediately after preparing the emulsions of the following Examples and Comparative Examples at room temperature, 45° C. and a cycling constant temperature bath, they were stored for 10 days and 30 days, and the stability of the emulsion was observed depending on whether the hardness decreased, floating or separation of oil, etc. occurred. Therefore, it was evaluated as ○ if no phase separation occurred, and × if phase separation occurred.

(whitening effect)

To 210 μl of 100mM sodiumphosphate buffer (pH 6.8), 20 μl of mushroom tyrosinase and 40 μl of 1.5mM L-tyrosine were added to 30 μl of a mixture of 5% and 10% of the sample solution, and reacted at 37℃ for 15 minutes. Enzyme-Linked Immunosorbent Assay Absorbance was measured at 490 nm by (ELISA). Mushroom tyrosinase inhibitory activity was expressed as the decrease in absorbance of the sample solution and the control group, and vitamin C (50% by weight) was used as a positive control group.

(wrinkle improvement effect)

Add 2mM of substrate dissolved in 200mM Tris-HCL buffer (pH 8.0), prepare each test solution to a certain concentration, take 200ul of each test tube, and elastase solution (0.5 unis/ml) dissolved in 200mM Tris-HCL buffer (pH 8.0) 10 μl of the solution was added, reacted for 10 minutes, and absorbance was measured at 410 nm using Enzyme-Linked Immunosorbent Assay (ELISA). Elastase inhibitory activity was expressed as a decrease in absorbance of the sample solution and the control group.

(sensory evaluation)

For sensory evaluation of the specimens prepared in Examples and Comparative Examples, 20 women aged 20 to 49 years were allowed to use the specimens for 2 weeks. And whitening, wrinkle improvement, irritation, and overall acceptance were evaluated.

The sensory test was performed according to a five-point scale method (5: very good, 4: good, 3: average, 2: bad, 1: very bad), and after examining the above characteristics, it was rounded to two decimal places and arithmetic averaged.

(Examples 1 to 5)

First, a natural emulsifier in which hydrogenated lecithin and hydrogenated phosphatidylcholine were mixed in a weight ratio of 2: 1 was mixed with distilled water, and then ultrasonically crushed at 65° C. using an ultrasonic crusher (Ultrasonic Liquid Processor, QSONICA, USA). When the emulsifier is homogenized, the natural material is added, followed by ultrasonic crushing and mixing. When the components were completely homogenized, the ingredients listed in Table 1 below were mixed with each of the stirring and ultrasonic disruption to obtain a cosmetic composition containing liposomes.

[Table 1]

[Table 2]

[Table 3]

[Table 4]

As shown in Tables 2 to 4, it can be seen that the cosmetic compositions prepared according to the present invention have whitening and wrinkle-improving effects without phase separation. In particular, as the amount of the emulsifier increased, no phase separation occurred compared to Examples 1 and 2, and it can be seen that the whitening and wrinkle improvement effects were excellent.

As mentioned above, although the present invention has been described with reference to the illustrated embodiment, it will be understood that this is merely an example, and that various modifications and equivalent embodiments are possible therefrom by those of ordinary skill in the art. Accordingly, the true protection scope of the present invention should be defined only by the appended claims.

Claims (6)

a natural emulsifier comprising any one or a plurality of fatty acids selected from lecithin, hydrogenated lecithin, palmitic acid, stearic acid, oleic acid, linoleic acid and linolenic acid;
any one or a plurality of vitamins selected from vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, and vitamin K;
Any one or a plurality of stabilizers selected from potassium hydroxide, sodium hydroxide and triethanolamine; and
aroma oil;
A cosmetic vitamin composition encapsulated in nano liposomes, characterized in that it comprises a.
The method of claim 1,
The aroma oil is jojoba oil, avocado oil, almond oil, olive oil, sesame oil, wheat germ oil, safflower oil, camellia oil, castor oil, grape seed oil, green tea seed oil, macadamia nut oil, palm oil, rosehip oil, hydrogenated oil, A cosmetic vitamin composition encapsulated in nano liposomes, characterized in that it contains any one or a plurality selected from argan oil, sea buckthorn oil, argan tree kernel oil and lavender oil.
The method of claim 1,
The composition is a cosmetic vitamin composition encapsulated in nano-liposomes, characterized in that it comprises 1 to 30% by weight of a natural emulsifier, 1 to 30% by weight of vitamins, 1 to 10% by weight of a stabilizer, and 50 to 70% by weight of an aromatic oil.
A cosmetic composition comprising a vitamin composition for cosmetics encapsulated in nano-liposomes according to any one of claims 1 to 3.
5. The method of claim 4,
The cosmetic composition comprises 0.1 to 90% by weight of the cosmetic vitamin composition based on 100% by weight of the total total weight.
5. The method of claim 4,
The cosmetic composition includes a softening lotion, astringent lotion, nutritional lotion, nourishing cream, massage cream, eye cream, serum, cleansing cream, cleansing foam, cleansing water, pack, body lotion, body cream, body oil, body essence, makeup base, A cosmetic composition, characterized in that it has any one or a plurality of formulations selected from the group consisting of foundation and body cleanser.