KR102516717B1 - A cosmetic composition for improved skin having panthenol and niosome - Google Patents

Abstract

A cosmetic composition for skin improvement according to the present invention, by carrying active ingredients of panthenol, ectoin and allantoin in niosome, increases the stability of the active ingredients, increases the solubility and skin penetration rate, and at the same time, while suppressing the allergen action, which is a side effect of panthenol, can increase effects of skin soothing, irritation relief, continuous moisturizing and the like.

Description

A cosmetic composition for improved skin containing panthenol and niosome as active ingredients {A cosmetic composition for improved skin having panthenol and niosome}

The present invention relates to a cosmetic composition for skin improvement comprising panthenol and niosome as active ingredients, and in detail, by containing the active ingredients of panthenol, ectoin and allantoin in niosome to increase the stability of the active ingredients, solubility and skin The present invention relates to a cosmetic composition for skin improvement containing panthenol and niosome as active ingredients capable of increasing the penetration rate and at the same time increasing effects such as skin soothing, irritation relief, and continuous moisturizing.

In general, active ingredients that relieve skin irritation or provide continuous moisturizing are difficult to be absorbed into the skin because they have a very large molecular weight. Therefore, it is very important to control the size of the particles so that these active ingredients can penetrate the skin.

A nanoemulsion usually made is a nanoliposome, and a liposome is a closed vesicle formed of a lipid bilayer, and contains cosmetic ingredients in the aqueous phase within the vesicle space. As for liposomes, double membrane structures such as SUV (small unilamellar vesicle), LUV (large unilamellar vesicle), and GUV (giant unilamellar vesicle) are known, and multilamellar vesicles (MLV) are composed of five or more such double membranes. do.

These general nanoemulsions can entrap liquid oil components in closed vesicles, and these nanoemulsions can destroy the entrapped oil components by osmotic action with the external water phase. To prevent this, the liquid oil components are solidified. SLN (soiled Lipid Nanoparticle) is made of lipids, and these SLNs have little external and osmotic action, so active ingredients are well preserved. However, since the oily component is a solid lipid, the nanoemulsion hardens over time. In order to compensate for this drawback, oil is added in an amount of 5 to 10% by weight to prevent the nanoemulsion from hardening (NLC).

In addition, conventional liposomes cannot penetrate the active ingredients deep into the skin because the walls of the liposomes are not elastic. Therefore, transfersomes (elastic liposomes/elastic liposomes/flexible liposomes) make the walls of these liposomes elastic to facilitate skin penetration. is called

Niosome is a double-membrane transporter composed of nonionic surfactants that is biodegradable, can encapsulate polar and non-polar substances, and is more stable than liposomes. there is.

Although niosomes and liposomes are structurally similar, differences in properties exist between liposomes and niosomes because niosomes are prepared from uncharged single-chain surfactants and cholesterol, whereas liposomes are prepared from double-chain phospholipids. Stabilization of these endoplasmic reticulum is governed by cholesterol components that maintain membranes (Membrances). Niosomes composed of nonionic surfactants cannot be expected to play the same role as lipids with only the nonionic surfactants themselves, and must be made similar to natural lipid components. It is used to make it have masculine properties. Niosomes are advantageous in that they can encapsulate polar and non-polar substances, are osmotically active, and do not require special conditions for storage and handling of surfactants used in their preparation.

On the other hand, panthenol (Panthenol) is a precursor of vitamin B5, which is decomposed in the body and converted into pantothenic acid. Panthenol is already known to have an effect of improving the skin's ability to retain moisture, and is widely used in rash creams and ointments. In particular, when panthenol is included in an amount of 5%, it is known to have remarkable effects on strengthening the skin barrier, regenerating the skin, and supplying moisture.

Panthenol is topically applied to atopic dermatitis and diaper rash as its ability to moisturize the skin and restore the skin barrier promotes epidermal regeneration. In addition, it can promote wound healing by promoting proliferation and epithelialization of fibroblasts. As a result of the study, it was found that 5% panthenol emulsion induces reduction of erythema theme and increase in elasticity and solid tissue regeneration (Proksch, et al., 2017), and daily application of 5% D-panthenol has the potential to alleviate nipple cracks (Kus, et al., 2017). et al., 2002). Furthermore, D-panthenol has a good effect on daily management of scars caused by skin grafts and burns (Buttemeyer, et al., 1995).

However, cosmetic compositions for skin improvement containing panthenol and niosome in the form of a lotion with increased panthenol content as active ingredients are manufactured and applied to absorbent products when the content of panthenol or niosome is maintained at a high concentration. It has a problem of poor stability in the application process. In particular, since panthenol has hydrophilicity, when it is included in a high concentration, it shows instability in conventional wax-based formulations and tends to precipitate during the manufacturing process. Here, depending on the person, dexpanthenol acts as an allergen, causing allergic contact dermatitis in some people.

Republic of Korea Patent Registration No. 10-2102578 (April 14, 2020)

The present invention has been made to solve the above problems, and in detail, by carrying the active ingredients of panthenol, ectoin and allantoin in niosome, the stability of the active ingredients is increased, solubility and skin penetration rate are increased, and at the same time, panthenol It relates to a cosmetic composition for skin improvement containing panthenol and niosome as active ingredients capable of enhancing effects such as skin soothing, irritation relief, and continuous moisturizing while suppressing the side effect of allergens.

The present invention relates to a cosmetic composition for skin improvement comprising panthenol and niosome as active ingredients.

One aspect of the present invention relates to a cosmetic composition for skin improvement comprising panthenol and niosome containing panthenol, ectoin and allantoin supported therein as active ingredients.

In the present invention, the panthenol, ectoin, and allantoin may each be contained in an amount of 0.001 to 10% by weight based on the total weight of niosome, and the niosome includes a nonionic surfactant, cholesterol, a co-emulsifier, and a stabilizer can be formed by

In addition, the niosome has an average particle diameter of 10 to 200 nm, and the composition may include 0.1 to 10 wt% of niosome based on 100 wt% of the total.

Here, the composition is skin, emulsion, cream, sunscreen, foundation, essence, gel, pack, mask pack, foam cleanser, body cleanser, softening lotion, eyeliner, shampoo, conditioner, soap, hairdressing agent, hair conditioner, hair cream, It may have any one formulation selected from the group consisting of hair styling gel, lubricant, toothpaste, aerosol, and transdermal patch.

The cosmetic composition for skin improvement according to the present invention contains active ingredients of panthenol, ectoin, and allantoin in niosome, thereby increasing the stability of the active ingredients, increasing solubility and skin penetration rate, and at the same time suppressing allergen action, which is a side effect of panthenol It can increase the effect of skin soothing, irritation relief, and continuous moisturizing.

Hereinafter, the cosmetic composition for skin improvement containing panthenol and niosome as active ingredients according to the present invention will be described in more detail through specific examples. The specific examples introduced below are provided as examples to sufficiently convey the spirit of the present invention to those skilled in the art.

Therefore, the present invention may be embodied in other forms without being limited to the specific examples presented below, and the specific examples presented below are only described to clarify the spirit of the present invention, but the present invention is not limited thereto.

At this time, if there is no other definition in the technical terms and scientific terms used, they have meanings commonly understood by those of ordinary skill in the art to which this invention belongs, and will unnecessarily obscure the gist of the present invention in the following description. Descriptions of possible known functions and configurations are omitted.

Also, the singular forms used in the specification and appended claims may be intended to include the plural forms as well, unless the context dictates otherwise.

Also, terms such as first, second, A, B, (a), and (b) may be used in describing the components of the present invention. These terms are only used to distinguish the component from other components, and the nature, order, or order of the corresponding component is not limited by the term. When an element is described as being “connected,” “coupled to,” or “connected” to another element, that element is directly connected or connectable to the other element, but there is another element between the elements. It will be understood that elements may be “connected”, “coupled” or “connected”.

In the present invention, the term 'external skin preparation' is a concept encompassing the overall composition applied to the skin, and includes, for example, various cosmetics such as basic cosmetics, makeup cosmetics, and hair cosmetics; It is a concept that includes pharmaceutical compositions applied externally to the skin, including pharmaceuticals and quasi-drugs such as ointments, creams, and lotions.

In the present invention, the term 'noisome' is a non-ionic surfactant-based vesicle, which has a hydrophilic space inside and a closed double lipid membrane with hydrophobic properties on the outside. It means a fine molecular sieve that has

The term ‘non-ionic surfactant’ is a surfactant that is not separated into ions, and is also referred to as non-ionic surfactant or non-ionic surfactant. Unlike ionic surfactants, nonionic surfactants can be freely mixed with other surfactants or electrolytes. It is harmless to the skin, thickens the shampoo base, improves stability at low temperatures, and has excellent washing action but less foaming, so it can be used for various purposes such as dispersing agent, emulsion agent, detergent, and dyeing aid. .

In the present invention, the cosmetic composition for skin improvement containing panthenol and niosome as active ingredients may include panthenol, ectoin, and allantoin niosome loaded therein.

The panthenol refers to a water-soluble provitamin, also called provitamin B5, which is converted into vitamin B5 in the body, and inhibits the activity of cyclooxygenase that metabolizes prostaglandin and lukotriene, which are inflammatory mediators, thereby reducing itching. It prevents or imparts moisture to the skin mucosa. In addition, it promotes cell growth, functions to maintain skin moisture, provides gloss to the skin mucous membrane, and has an effect of preventing skin aging such as wrinkles, elasticity, and melasma.

The panthenol is preferably included in an amount of 0.001 to 10% by weight, more preferably 3 to 5% by weight, based on the total weight of the niosome. If the supported amount of panthenol is less than the above range, the aforementioned effects such as anti-itching, moisturizing, and skin aging prevention are insufficient, and if it exceeds the above range, panthenol may act as an allergen and cause side effects such as skin rash. Due to the high hydrophilicity of the moths, the loading yield may also be reduced.

Ectoin (CAS number: 96702-03-3) is a well-known organic compound with the chemical formula C6H10N2O2 that occurs naturally in bacteria. It is also referred to as (S)-2-methyl-3,4,5,6-tetrahydropyrimidine-4-carboxylic acid. Ectoin is obtainable by techniques well known in the art, especially from various bacteria of the genus Halomonadaceae or Firmicutes.

Since the ectoin acts to form a protective barrier by surrounding the surface of skin cells or proteins in the skin, it can block the penetration of fine dust. Specifically, ectoin has the property of bonding well with surrounding water molecules, forming an ectoin water complex, and the formed ectoin water complex surrounds skin cells or proteins in the skin, forming a protective barrier on the skin surface. It is formed to block the penetration of fine dust.

In addition, ectoin can function to protect the skin from being damaged by particles or ultraviolet rays (UVA/UVB) that cause wrinkle formation and pigmentation, and thus can exhibit an effect of preventing skin aging. Ectoin can also function to soothe the skin damaged by inflammation, prevent itching, and activate the skin regeneration process, thereby improving or treating skin conditions (such as atopic dermatitis, allergic dermatitis, or acne treatment). there is.

The ectoin is preferably included in an amount of 0.001 to 10% by weight, more preferably 0.1 to 2% by weight, based on the total weight of the niosome. When the content of ectoin is less than the above range, the above-described skin soothing effect and anti-itching effect are insufficient, and when it exceeds the above range, skin irritation may be increased and an allergic reaction may be induced.

The allantoin is a compound of CAS number 97-59-6, and is a ureide compound of glyoxylic acid. Allantoin is a natural substance extracted from places such as oak, comfrey root, sugar beet, and wheat sprouts, and is known to have an action of enhancing cell proliferation, an action of promoting wound repair, an anti-inflammatory action of the conjunctiva, and an anti-allergic action. As a particularly effective skin protection active ingredient, it helps heal small wounds or troubles on the skin, promotes the regeneration of healthy skin cells, and at the same time suppresses the allergic antigen action that can be caused by panthenol and ectoin. .

The allantoin is preferably included in an amount of 0.001 to 10% by weight, more preferably 0.1 to 1% by weight, based on the total weight of the niosome. If the content of allantoin is less than the above range, the above-mentioned skin moisturizing, cell proliferation, and anti-allergic effects are insignificant, and if it exceeds the above range, the yield of supported niosomes may decrease due to the low solubility peculiar to allantoin.

The niosome may be formed by including a nonionic surfactant, cholesterol, a co-emulsifier and a stabilizer.

The nonionic surfactant may have a hydrophilic-lipophilic balance (HLB) of 3 to 6, specifically 4 to 6, but is not necessarily limited thereto, and an emulsifier (emulsifier or emulsifying agent), more specifically A nonionic surfactant having the property of a water-soluble emulsifier and capable of dissolving cholesterol in an aqueous solvent can be used.

Examples of the nonionic surfactant include polyoxyethylene alkyl esters and polyoxyethylene alkyl ethers, more specifically sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan mono Sorbitan fatty acid esters such as palmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, and diglycerol sorbitan tetra-2-ethylhexylate and the like, more preferably sorbitan alkyl esters, polyglycerin fatty acid esters and the like.

The nonionic surfactant may include 4 to 10% by weight, more preferably 5 to 7% by weight based on the total weight of niosome. If the amount of the nonionic surfactant is less than the above range, the generation of niosomes is not properly performed, and if the amount exceeds the above range, the particle size of the niosome may become excessively large, resulting in poor absorption into the skin.

In the present invention, the cholesterol (cholesterol) is a kind of steroid (steroid), a basic substance constituting the cell membrane of animal cells, and is a precursor of several steroid substances. It is represented by the chemical formula C27H46O, and is insoluble in water, acids and alkalis, but soluble in organic solvents such as ether and chloroform. The cholesterol includes derivatives of cholesterol. The derivative of cholesterol can be, for example, sitosterol, ergosterol, stigmasterol, 4,22-stigmastadien-3-one, stigmasterol acetate, lanosterol, cycloartenol, or combinations thereof. Cholesterol can help strengthen the lipid bilayer and lower permeability.

In the present invention, the amount of cholesterol added is not limited, but it is preferable to include 0.01 to 10% by weight, more preferably 0.1 to 1% by weight based on the total weight of the total niosome. If the content of cholesterol is out of the above range, formation of niosome may not be performed properly.

In the present invention, the auxiliary emulsifier is a material that assists the surfactant so that the hydrophilic material and the hydrophobic material are mixed without phase separation in the solvent, but is not limited to the type of higher alcohol (cetyl alcohol, stearyl alcohol, myristyl alcohol) , behenyl alcohol, cetostearyl alcohol, cetearyl alcohol), ester oil (isopropyl myristate, cetyl octanoate, oleyl oleate, isobutyl adipate, 2-ethylhexanoate, cetyl monoisostearate, N -alkyl glycol) or lecithin, preferably containing lecithin.

The lecithin refers to naturally occurring or synthetic lecithin that can be suitably purified. Suitable lecithins include, but are not limited to, egg or soy derived lecithin. More suitable lecithins are dihexanoyl-L-alpha-lecithin, dioctanoyl-L-alpha-lecithin, didecanoyl-L-alpha-lecithin, didodecanoyl- L-alpha-lecithin, ditetradecanoyl-L-alpha-lecithin, dihexadecanoyl-L-alpha-lecithin, dioctadecanoyl-L-alpha-lecithin, dioleo yl-L-alpha-lecithin, dilinoleoyl-L-alpha-lecithin, alpha-palmitol.

Lecithin is a mixture of diglycerides of fatty acids, usually linked to choline esters of phosphoric acid, and may contain different amounts of other compounds depending on the method of isolation. Typically, commercial lecithin is a mixture of acetone-insoluble phosphatides. Preferably, the lecithin is obtained from seeds including soybeans and corn, most preferably soybeans, using methods well known in the art. Lecithin obtained from soybean is referred to as soybean lecithin in the present invention.

The auxiliary emulsifier preferably contains 1 to 10% by weight based on the total weight of the total niosome. If the content of the auxiliary emulsifier is less than the above range, there is a problem that the stability of the niosome is lowered, and when it exceeds the above range, there is a problem that the feeling of use of the cosmetic composition is deteriorated.

The stabilizer is added to form a phase inside the niosome and to stabilize the niosome, and in addition, serves to improve the moisturizing power of the cosmetic composition and improve the feeling of use. Examples of such stabilizers include betaine, butylene glycol, polyhydric alcohols, organic acids, organic salts, complexes of sugars and proteins, and polyols including glycerin, propylene glycol, and dipropylene glycol. One or more selected ones may be used, more preferably glycols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol, and polyethylene glycol; polyhydric alcohols such as 1,2-hexanediol; Glycerols, such as glycerol, diglycerol, and polyglycerol; sugars such as sorbitol, mannitol, sugar, starch sugar, and lacuchitol; Guar gum, sodium chondroitin lactate, sodium hyaluronate, sodium alginate, methylcellulose, hydroxymethylcellulose, carboxyvinyl polymer, polyvinyl alcohol, polyvinylpyrrolidone, alkylated carboxylvinyl polymer, sodium polyacrylate, gum arabic, carrageenan water-soluble polymers such as; Salts, such as sodium chloride, magnesium chloride, and sodium lactate; and the like, among which glycerin is preferably included.

The stabilizer is preferably included in an amount of 20 to 60% by weight based on the total weight of the niosome. When the amount of the stabilizer is less than the above range, the formation of the internal phase of niosome is not properly performed and the stability of the niosome is not good.

The components may be added to a solvent and stirred to completely mix them. The solvent used at this time is not limited in the present invention as long as it is a water-soluble solvent, and preferably includes low alcohol such as ethanol, phosphate buffered saline (PBS), physiological saline or water.

The amount of the solvent added is not limited, and it is preferable to include 20 to 70% by weight based on 100% by weight of the total niosome.

The niosome in the present invention is not limited to the manufacturing method. For example, the niosome is prepared by: ① preparing an aqueous phase by heating and dissolving water-soluble components such as panthenol, ectoin, allantoin, a stabilizer, and a solvent at 70 to 100 ° C; ② preparing an oil phase by heating and dissolving cholesterol and a stabilizer, which are useful components, at 50 to 100 ° C; ③ preparing an emulsifier part by heating and dissolving a nonionic surfactant and a co-emulsifier in a stabilizer at 50 to 80 ° C; ④ Putting the water phase part and the oil phase part into a homo mixer and stirring at 1,000 to 5,000 rpm, then adding the emulsifier part and stirring at 1,000 to 5,000 rpm to form niosomes; and ⑤ stabilizing the niosome-formed composition while cooling it to room temperature (around 20° C.).

At this time, when mixing the niosome composition, it is preferable to use a general homomixer instead of a high pressure homogenizer, which is not a separate mechanical device. In the case of a high-pressure emulsification device, it takes a lot of time and energy to adjust the internal pressure or temperature within a certain range. It can be shortened significantly, so the efficiency is excellent.

The niosome prepared as above is not limited in average particle diameter, but may satisfy the average particle diameter of 10 to 200 nm. If the average particle diameter of niosomes is less than the above range, the amount of the active ingredient supported may be too small, so the above-mentioned effects may not be properly expressed. may not be

The present invention may include a cosmetic composition for skin improvement containing niosome carrying an active ingredient as described above. At this time, the cosmetic composition may include 0.1 to 10% by weight of niosome based on 100% by weight of the total composition. Within the above range, effects such as skin soothing, irritation relief, moisturizing improvement, skin penetration enhancement, and the like can be maximized.

The cosmetic composition may be any formulation known as a cosmetic composition in the art, for example, skin, emulsion, cream, sunscreen, foundation, essence, gel, pack, mask pack, foam cleanser, body cleanser, softening lotion, It may be any one formulation selected from the group consisting of eyeliner, shampoo, rinse, soap, hairdressing agent, hair conditioner, hair cream, hair styling gel, lubricant, toothpaste, aerosol, and transdermal patch, but the present invention is not limited thereto. .

The cosmetic composition may further include various known additives within a range that does not impair the effect of the cosmetic composition according to the formulation, and according to one embodiment, a carrier, a solvent, a surfactant, an emulsifier, a thickening agent, a conditioner, It may further contain emollients, skin care ingredients, humectants, thickeners, lubricants, fillers, antioxidants, other preservatives, active ingredients, particularly dermatologically active ingredients and fragrances, and mixtures thereof.

Examples of the carrier include animal fibers, vegetable fibers, wax, paraffin, starch, tragacanth, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc, zinc oxide, lactose, silica, aluminum hydroxide, calcium silicate, poly Amide powder, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol, liquid diluent, ethoxylated isostearyl alcohol, Suspending agents such as polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, microcrystalline cellulose, aluminum metahydroxide, bentonites, agar or tragacanth, aliphatic alcohol sulfates, aliphatic alcohol ether sulfates, sulfosuccinic acid monoesters, ise Thionates, imidazolinium derivatives, methyl taurates, sarcosinates, fatty acid amide ether sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linolin derivatives, or ethoxylated It may include glycerol fatty acid ester and the like, but is not limited thereto.

Examples of the surfactant include alkyl sulfates (eg, sodium lauryl sulfate, ammonium lauryl sulfate, and sodium cetearyl sulfate); alkyl sulfoacetates (eg sodium lauryl sulfoacetate); alkyl ether sulfates (eg, sodium laureth sulfate, sodium tridecet sulfate, sodium oleth sulfate, ammonium laureth sulfate); alkyl ether sulfosuccinates (eg disodium laureth sulfosuccinate); alkyl glycosides (eg, decyl glucoside, lauryl glucoside); Alkyl isethionate amphoteric compounds (e.g. cocamidopropyl betaine, sodium cocoamphoacetate, sodium lauroamphoacetate, disodium lauroamphodiacetate, disodium cocoamphodiacetate, sodium lauroam porpripionate, disodium lauroamphodipropionate, potassium or ammonium salts of the aforementioned amphoteric compounds, capryl/capramidopropyl betaine, undecyleneamidopropyl betaine, lauromidopropyl betaine) and fatty alcohol poly Glycol ether etc. are mentioned.

These emulsifiers include salts of fatty acids, such as sodium stearate or sodium palmitate, organic soaps, such as mono-, di- or triethanolaminolate, sulfurized or sulfonated compounds, such as sodium lauryl sulfate or sodium cetyl. sulfonates), saponins, ramefons; cationic compounds (e.g. quaternary ammonium salts); nonionic compounds (e.g. fatty alcohols, fatty acid esters with saturated or unsaturated fatty acids, polyoxyethylene esters of fatty acids) or polyoxyethylene ethers, polymers from ethylene oxide and propylene oxide or propylene glycol), amphoteric compounds (e.g. phosphatides), proteins (e.g. gelatin, casein, alkylamidobetaines, alkyl betaines and amphoglyces) cinate), alkyl phosphates, alkylpolyoxyethylene phosphates or corresponding acids, silicone derivatives (eg, alkyl dimethicone copolyol), and the like.

Examples of the viscosity agent include fatty alcohols or fatty acid esters and mixtures thereof, such as acetylated lanolin alcohol, aluminum stearate, carbomer, cetyl alcohol, glyceryl oleate, glyceryl stearate, glyceryl stearate (and) PEG 100 stearate, magnesium stearate, magnesium sulfate, oleic acid, stearic acid, stearyl alcohol, myristyl myristate, isopropyl palmitate, beeswax and its synthetic equivalents and carbomers; and the like.

The conditioner includes alkylamido ammonium lactate, cetrimonium chloride and distearoylethyl hydroxyethylmonium methosulfate and cetearyl alcohol, cetyl dimethicone, cetyl ricinoleate, dimethicone, laureth-23, laureth-4, polydecene, retinyl palmitate, quaternized protein hydrolysates, quaternized cellulose and starch derivatives, quaternized copolymers of acrylic acid or methacrylic acid or salts, quaternized silicone derivatives, and the like.

Examples of the softening agent include cetearyl isononanoate, cetearyl octanoate, decyl oleate, isooctyl stearate, coco caprylate/caprate, ethylhexyl hydroxystearate, ethylhexyl isononanoate, Isopropyl Isostearate, Isopropyl Myristate, Oleyl Oleate, Hexyl Laurate, Paraffinum Liquidum, PEG-75 Lanolin, PEG-7 Glyceryl Cocoate, Petrolatum, Ozokerite Cyclomethicone, Dimethicone , Dimethicone Copolyol, Dicaprylyl Ether, Butyrospermumparchy, Buxus Chinensis, Canola, Carnauba Sera, Copernicia Serifera, Oenothera Biennis, Elais ginensis, Prunus dulcis, squalane, zea may, glycine soya, helianthus annus, lanolin, hydrogenated castor oil, hydrogenated polyisobutene, sucrose cocoate, stearoxy dimethicone, lanolin alcohol, isohexadecane and the like.

Examples of the skin protection component include plant extracts, bisabolol, anti-inflammatory agents, urea, allantoin, panthenol and panthenol derivatives, phytantriol, vitamins A, E, C, D, animal or plant-derived ceramides and lecithin, and the like. .

Examples of the humectant include butylene glycol, cetyl alcohol, dimethicone, dimyristyl tartrate, glucose glycereth-26, glycerin, glyceryl stearate, hydrolyzed milk protein, lactic acid, lactose and other sugars, laureth-8, Lecithin, Octoxy Glycerin, PEG-12, PEG-135, PEG-150, PEG-20, PEG-8, Pentylene Glycol, Hexylene Glycol, Phytantriol, Polyquaternium-39 PPG-20 Methyl Glucose Ether, propylene glycol, sodium hyaluronate, sodium lactate, sodium PCA, sorbitol, succinoglycan, synthetic beeswax, tri-C14-15 alkyl citrate, starch and the like.

Examples of the thickener include acrylate/steareth-20 methacrylate copolymer, carbomer, carboxymethyl starch, sera alba, dimethicone/vinyl dimethicone crosspolymer, propylene glycol alginate, hydroxyethylcellulose, hydroxypropyl methyl cellulose, silica, silica dimethyl silylate, xanthan gum, hydrogenated butylene/ethylene/styrene copolymer, and the like.

The lubricant includes adipic acid, fumaric acid and its salts, benzoic acid and its salts, glycerin triacetate, sodium or magnesium lauryl sulfate, magnesium stearate, solid polyethylene glycol, polyvinylpyrrolidone, boric acid, mono-laurate or mono-palmitate, myristyl alcohol, cetyl alcohol, cetylstearyl alcohol, talc, calcium or magnesium salts of higher fatty acids, mono-, di- or triglycerides of higher fatty acids, polytetrafluoroethylene and the like.

Examples of the antioxidant include sulfite (e.g. sodium sulfite), tocopherol or a derivative thereof, ascorbic acid or a derivative thereof, citric acid, propyl gallate, chitosan glycolate, cysteine, N-acetyl cysteine + zinc sulfate, thiosulfate (e.g. sodium thiosulfate) and polyphenols.

In addition, the composition may include various active ingredients depending on the application site of the skin. Examples of such active ingredients include antimicrobial agents, anti-inflammatory agents, plant extracts, bisabolol, panthenol, tocopherol, anti-cut, anti-irritant or anti-dandruff actives, or anti-aging agents such as retinol and melibiose. can contain. Other suitable active agents are, for example, Medicago officinalis, Actinidia chinensis, allantoin, Aloe barbadensis, Anona cherimolia , Anthemis nobilis, Arachis hypogaea, Arnica Montana, Avena sativa, beta-carotene, bisabolol, Borago officinalis officinalis), butylene glycol, Calendula officinalis, Camellia sinensis, camphor, Candida bombicola, capryloyl glycine, Carica papaya, Centaurea cyanus, cetylpyridinium chloride, Chamomilla recutita, Chenopodium quinoa, Chinchona succirubra, Chondrus crispus), Citrus aurantium dulcis, Citrus grandis, Citrus limonum, Cocos nucifera, Coffea Arabica, Crataegus monogina, Cucumis melo, dichlorophenyl imidazoledioxolane, Enteromorpha compressa, Equsetum arvense, ethoxydiglycol, ethyl panthenol , farnesol, ferulic acid, Fragaria chiloensis, Gentiana lutea, Ginkgo biloba (Gi nkgo biloba), glycerin, glyceryl laurate, Glycyrrhiza glabra, Hamamelis virginiana, heliotropin, hydrogenated palm glycerides, citrate, hydrolyzed castor oil, hydrolyzed Degraded Wheat Protein, Hypericum perforatum, Iris florentina, Juniperus communis, Lactis proteinum, Lactose, Lausonia Iner Lawsonia inermis, linalool, Linum usitatissimum, lysine, magnesium aspartate, Magnifera indica, Malva sylvestris, mannitol, Mel Melaleuca egg Melaleuca alternifolia, Mentha piperita, menthol, methyl lactate, Mimosa tenuiflora, Nymphaea alba, olaflur, Oryza sativa sativa), Panthenol, Paraffinum Liquidum, PEG-20M, PEG-26 Jojoba Acid, PEG-26 Jojoba Alcohol, PEG-35 Castor Oil, PEG-40 Hydrogenated Castor Oil, PEG-60 Hydrogenated Castor Oil, PEG-8 Car Pril/capric acid, Persea gratissima, petrolatum, potassium aspartate, potassium sorbate, propylene glycol, Prunus amygdalus dulcis, Prunus armeniaca ), Prunus persica, Retinyl Palmitate, Ricinus communis, Rosa canina, Rosmarinus officinalis, Rubus Idaeusidaeus), salicylic acid, Sambucus nigra, sarcosine, Serenoa serrulata, Simmondsia chinensis, sodium carboxymethyl betaglucan, sodium cocoyl amino acid, sodium hyaluronic acid. Ronate, sodium palmitoyl praline, stearoxytrimethylsilane, stearyl alcohol, sulfurized TEA-ricinoleate, talc, Thymus vulgaris, Tilia cordata, tocopherol, tocopheryl acetate, tri and the like.

The above components may be added by freely adjusting the addition amount within a range that does not impair the object of the present invention, but the present invention is not limited thereto.

Preferred embodiments of the present invention will be described in detail with reference to Examples and Comparative Examples below. However, the following examples are only one example for explaining the present invention in more detail, and the present invention is not limited by the following examples.

(Examples 1 to 5 and Comparative Examples 1 to 7)

In order to determine whether there is an effect of inhibiting inflammation and improving skin irritation of niosomes containing active ingredients such as panthenol, niosomes were prepared by the following method using the raw materials and contents shown in Table 1 below.

First, water-soluble raw materials such as panthenol, ectoin, allantoin, and a stabilizer were mixed with purified water as a solvent and dissolved at 80° C. to prepare an aqueous phase. Separately, cholesterol, which is an oil-soluble component, is mixed with polyols, which are stabilizers, and dissolved at 80° C. to prepare the oil phase. An emulsifier part was prepared by dissolving the mixed mixture in a weight ratio of 1: 1 and lecithin as an auxiliary emulsifier in polyols at 70 ° C. At this time, each component was mixed in the weight % described in Table 1 below.

Then, the prepared water phase part and the oil phase part were put into a homomixer and stirred at 3,000 rpm, and then the emulsifier part was added thereto and stirred at 3,000 rpm to form niosomes loaded with active ingredients. After the formation of niosomes, they were stabilized by cooling at room temperature. In Comparative Example 7, each component was simply mixed at room temperature (25° C.).

[Table 1]

(Experimental Example 1) - Particle size analysis of niosomes

In order to investigate the distribution and size of the particles of the prepared niosome composition, a laser light scattering method (light scattering, instrument model; Microtrac S3000, Microtrac Co. Ltd, USA) was used, and each scan was performed by scanning three times for 30 seconds each. The average particle size was measured. In addition, in order to evaluate the stability of the nanoformulation through time-lapse comparison according to temperature, the average particle size was measured after storage for one month under cold and 45 ° C storage conditions.

[Table 2] - Average particle size (nm) of niosome composition

As a result of confirming the particle size of the niosome as shown in Table 2, it was formed in a nanosize of about 150 nm, and it can be seen that the stability of the niosome particle is excellent in a low temperature or high temperature state. However, it can be seen that no niosome was formed when the oily component and the hydrophilic component were simply mixed as in Comparative Example 7.

(Experimental Example 2) - Physical stability

In order to evaluate the physical stability of the examples, etc., centrifugation (equipment model name; Micro High Speed centrifuge, MICRO 17TR, Hanil, Korea) was used to repeat centrifugation at 10,000 RPM for 10 minutes each 5 times in 1 set, and phase separation or precipitation Changes in the stability of the formulations were observed.

[Table 3]

(In Table 3, ◎ means good, ○ means some precipitation and oil separation, and × means precipitation and clear phase separation.)

As shown in Table 3, it can be seen that the niosome prepared according to the present invention has high stability. However, it was confirmed that the phase separation was severe when the amount of allantoin added was too large as in Example 5 or Comparative Example 5 or when the components were simply mixed as in Comparative Example 7.

(Experimental Example 3) - Skin transmittance

Skin permeability was confirmed using a Franz glass cell (Standard diameter 9 mm, Receiver 5 ml, Permegear). Specifically, pig skin (0.7 mm thickness, Medikinetics) to which 50 mg of the specimen prepared in Example was applied was installed between the upper and lower ends of the glass cell, and 500 μl and 5 ml of each were applied to the upper and lower ends of the glass cell, respectively. of TBS (50 mM Tris pH 7.5, 150 mM NaCl) was added. After 8 hours, the pig skin tissue was crushed to quantitatively analyze the amount of active ingredient, and the permeation amount per unit area (μg/cm 2 ) is shown in Table 4 below.

[Table 4]

As shown in Table 4, it can be seen that the skin permeability of Examples 1 to 5 including all active ingredients is significantly improved compared to Comparative Examples. In particular, in Comparative Examples 1 to 6, in which either ectoin or allantoin was excluded, the number of components permeable to the skin was reduced compared to other examples, and in Comparative Example 7, in which no niosome was formed, the active ingredient It can be seen that the penetration amount is the lowest.

(Experimental Example 4) - Anti-inflammatory sensory test

Evaluation method using arachidonic acid to confirm the anti-inflammatory effect of niosome [A. Crummey, G. P. Harper, E. A. Boyle and F. R. Mangan. Inhibition of arachidonic acid-induced ear edema as a model for assessing topical anti-inflammatory compound. Agents and Actions, 1987, 20, p.69~76] was used as follows.

After dividing hairless mice into 7 mice per sample, both ears were washed thoroughly with ethanol before sample application, measured using a micrometer, and a sample group treated with 2.0% of niosome and indomethacin in Examples and the like. (Indomethacin) 2.0% treated control group, and arachidonic acid only treated control group, the experiment was conducted to measure the average value of the thickness of the ears of the mice. 20 μl of the sample was applied to the sample group and the control group treated with indomethacin, and 20 μl of ethanol was continuously applied to the control group once a day for 4 days. After 1 hour from the last application, ethanol was applied to the left ear and 2 mg/ear of arachidonic acid was applied to the right ear, and 1 hour after application, the degree of eaema of the ear was measured using a micrometer for both ears 3 times each. repeated measurements. The left ear of the treated group was used as a control group to determine the degree of inflammation caused by the sample itself. The anti-inflammatory effect was determined by the degree of edema inhibition based on the control group treated only with arachidonic acid, and the results are shown in Table 5.

[Table 5]

(Inhibition rate (%) = (A - B) / A × 100

A: Change in mean thickness of control ears (thickness of ears treated with arachidonic acid - thickness of ears not treated)

B: Change in average thickness of the ear of the sample application group (thickness of the sample treated ear - thickness of the non-treated ear)

As shown in Table 5, it can be seen that the niosome prepared according to the present invention exhibits a high inflammation inhibition rate of up to 43.3%. This inhibition rate value indicates an excellent anti-inflammatory effect of about 80% compared to indomethacin, which is a substance with excellent anti-inflammatory effect as a pharmaceutical ingredient. However, as in Examples 2 to 5, when the contents of ectoin and allantoin deviated from a certain level or more, it was confirmed that the inflammation inhibition rate decreased. It seems that panthenol induces allergens due to a small content of ectoin and allantoin, or that ectoin and allantoin are added excessively to act as allergens.

(Experimental Example 5) - Moisture retention and stimulation

First, after preparing the lotion as shown in Table 6 below, the feeling of use of the lotion was sensory evaluated for the subjects. The subjects were 20 adult women between the ages of 30 and 50 who used only one swatch after washing their face, and then classified the feeling of use into absorption, moistness, stickiness, nutrition, feeling after use, and irritation, and then evaluated according to the evaluation criteria described below. It is listed in Table 7.

[Table 6]

(Evaluation standard)

5: very good

4 : good

3 : Normal

2: bad

1 : very bad

[Table 7]

As shown in Table 7, it can be seen that the lotion prepared according to the present invention has excellent overall satisfaction in various evaluation areas such as absorption, moistness, stickiness, nutrition, feeling after use, and irritation. However, in Example 8 and Comparative Example 10, in which the amount of allantoin added was excessive, it could be confirmed that the niosome was not properly formed by allantoin or the allantoin was not dissolved, so that the feeling of use was extremely deteriorated.

(Experimental Example 6) - Moisturizing effect

After 1 hour of applying the lotion prepared in Examples 6 to 8 and Comparative Examples 8 to 11 centering on the upper arm, the amount of transepidermal water loss, TEWL, was measured using TEWAMETER TM210 (C+K electronic GmbH. Germany). (Transepidermal Water Loss) value was measured as △TEWL, the amount of change in TEWL value over time, and electrical conductivity according to the amount of epidermal moisture was measured using CORNEOMETER CM 820 PC (C+K electronic GmbH. Germany) to determine the sustainability of the moisturizing effect. measured.

[Table 8]

[Table 9]

As shown in Tables 8 and 9, the ΔTEWL value of Example 6 showed an improved effect on transepidermal water loss compared to Comparative Examples. In addition, in the Corneometer Value, which measures the moisture content of the skin, it can be seen that Example 6 increases by up to 30% or more compared to other comparative examples, so that the skin becomes very moist. This is because the lotion of Example 6 containing niosomes more easily penetrates the skin over time than other examples and comparative examples because the content of active ingredients is appropriate, thereby increasing the durability of the moisturizing effect. because it makes

Although the preferred embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements of those skilled in the art using the basic concept of the present invention defined in the following claims are also made according to the present invention. falls within the scope of the rights of

Claims (6)

Including panthenol, ectoin and allantoin loaded therein, characterized in that it contains 3 to 5% by weight of panthenol, 0.1 to 2% by weight of ectoin and 0.1 to 1% by weight of allantoin based on the total weight of the niosome A cosmetic composition for skin improvement comprising panthenol and niosome as active ingredients.
delete According to claim 1,
The niosome is a cosmetic composition for skin improvement comprising panthenol and niosome as active ingredients, characterized in that formed by including a nonionic surfactant, cholesterol, a co-emulsifier and a stabilizer.
According to claim 1,
The niosome is a cosmetic composition for skin improvement comprising panthenol and niosome as active ingredients, characterized in that the average particle diameter is 10 to 200 nm.
According to claim 1,
The composition is a cosmetic composition for skin improvement comprising panthenol and niosome as active ingredients, characterized in that it contains 0.1 to 10% by weight of niosome out of 100% by weight of the total.
According to claim 1,
The composition is skin, emulsion, cream, sunscreen, foundation, essence, gel, pack, mask pack, foam cleanser, body cleanser, softening lotion, eyeliner, shampoo, conditioner, soap, hairdressing agent, hair conditioner, hair cream, hair styling A cosmetic composition for skin improvement comprising panthenol and niosome as active ingredients, characterized in that it is in any one formulation selected from the group consisting of gel, lubricant, toothpaste, aerosol and transdermal patch.