JP2544167B2 - Hair growth and hair growth promotion charges - Google Patents

Description

TECHNICAL FIELD The present invention relates to a novel hair growth / hair growth promoting agent.

(Problems to be Solved by Conventional Techniques and Inventions) Conventionally, various compounds, extracts such as crude drugs, etc. have been applied to hair growth / hair growth promoters, but few have remarkable effects. Further, those having a certain degree of effect have drawbacks such as strong irritation to cause dermatitis and difficulty in continuous use.

(Means for Solving Problems) As a result of various experimental studies in view of such a current situation, the present inventors have Further, they have found that the above-mentioned conditions to be solved are satisfied by containing a crude drug extract obtained by extracting commercial land or walnut meat from a crude drug, and completed the present invention.

That is, the present invention Further, the present invention relates to a hair growth and hair growth-promoting agent, characterized by containing at least one crude drug extract obtained by extracting a crude drug of commercial or walnut meat with a water-soluble organic solvent or a water-containing water-soluble organic solvent.

 The present invention will be described in detail below.

As a method for obtaining a hair growth / hair growth promoter applied to the present invention, Or 100 g of crude drug of commercial or walnut meat, for example, a primary alcohol such as methanol, ethanol, propanol, butanol, or an organic solvent of acetone, tetrahydrofuran, dioxane alone, or 50% by weight or more of the primary alcohol or acetone, tetrahydrofuran, dioxane The water-containing organic solvent 11 contained is digested and extracted three times for 2 hours each. These extracts are combined, filtered with suction, and concentrated to dryness under reduced pressure to remove the solvent to obtain a viscous crude drug extract. The obtained herbal medicine extract is dissolved or dispersed and diluted with an appropriate solvent or the like into a base to obtain the hair growth and hair growth-promoting agent of the present invention.

Here, it is contained as an active ingredient of the hair-growth and hair-growth promoting agent according to the present invention. The content of one or more crude herb extracts of commercial and domestic walnut meat is 0.1-1
It is 0.0% by weight, preferably 0.5 to 5.0% by weight.

Applied to the present invention The hair growth and hair growth-promoting agent containing one or more crude herb extracts from walnut meat is used in the method for measuring the hair growth density of mice shown in Table 1 below, that is, other hair growth in Test Method I. -A remarkable effect was shown in comparison with a substance called a hair growth promoter. This is because the ingredients of the extracted crude drug extract from the above crude drug stimulate the hair root, and the blood circulation around the hair root becomes more active,
This is the result of better metabolism.

Brief Description of Test Method I Using 9-week-old C3H mice, one group has 10 mice,
Make 4 groups and apply 0.02g of the sample on the next day after removing hair to the area where the hair was removed to an area of 2.0 cm × 2.0 cm on the 9th day, 1
On the 1st and 14th days, the density of hair growth at the site was captured as a degree of increase in blackness using a formula difference meter and compared with conventional vitamin E as a comparative substance and 99.5% ethanol solution as a control.

In each sample applied in Table-1, A is a 99.5% ethanol solution containing 2% by weight of vitamin E as a comparative substance, and B, C and D are respectively A 99.5% ethanol solution containing 5% by weight of a crude drug extract obtained by commercial extraction of walnut meat with methanol, and E is 99.5% ethanol as a control.

Production example 1. Purchased from Osaka crude drug market 100 g was weighed and made into a coarse powder of about 20 mesh with a pulverizer, and then digested with 1 liter of 70 wt% methanol for 2 hours, and then the extract was filtered. The extraction filtrate obtained by repeating this extraction operation three times was combined and the solvent was distilled off at 60 ° C. under reduced pressure to obtain 8.6 g of a viscous dark brown crude drug extract having a peculiar odor.

Production Example 2. Walnut meat extract crude drug extract 100 g of walnut meat purchased from the Osaka crude drug market was weighed and made into a coarse powder of about 20 mesh with a crusher, and then 1 l of
Digestion was performed with 50% by weight ethanol for 2 hours, and then the extract was filtered. The extraction filtrates obtained by repeating this extraction operation three times were combined, and the solvent was distilled off at 60 ° C. under reduced pressure to obtain 9.4 g of a viscous dark brown crude drug extract having a peculiar odor.

Production Example 3. Soil and land extract crude drug extract 100g of Soil and land purchased from Osaka crude drug market is weighed and made into a coarse powder of about 20 mesh with a crusher, and then digested with 1 l of methanol for 2 hours, and then The extract was filtered. The extraction filtrates obtained by repeating this extraction operation three times were combined, and the solvent was distilled off under reduced pressure at 60 ° C. to obtain 10.3 g of a viscous dark brown crude drug extract having a peculiar odor.

 Next, examples of clinical trials will be shown.

Example 1 As a sample, A 99.5% ethanol solution containing 2% by weight of was used.

A sample of alopecia areata, a 44-year-old female with a 3 cm diameter bald area on the occipital region, was applied once a day with 3 to 5 g of the sample, and short vellus hair was produced at the bald area after about 3 months. After 6 months, the hair became bristles and the hair loss site disappeared.

Example 2 As a sample, a 99.5% ethanol solution containing 2% by weight of a mixture of the crude extract of walnut meat produced in Production Example 2 and the extract produced by commercial land extraction produced in Production Example 3 in a ratio of 1: 1 was used.

One sample per day for alopecia areata male, 36 years old, having hair loss parts 2.5 cm in diameter on the parietal region and the temporal region.
When 3 to 5 g was applied once per time, vellus hair was produced at the hair loss site of the crown and temporal region after 3 months, and vellus hair was produced after 6 months, but it was not completely cured.

In both Examples 1 and 2, no skin damage due to continuous application for 6 months was observed.

[Example] Next, a prescription example is shown. The mixing ratio is parts by weight.

Example 1 Hair tonic Manufacturing method 99.5% ethanol It was prepared by dissolving menthol and then adding purified water.

Example 2 Hair Cream Commercial land extract crude drug extract (Production Example 3) 1.0 Vaseline 7.0 Beeswax 8.0 Cristol 37.0 Emulsifier 5.5 Purified water 41.5 Method of manufacture Mixing the commercial land extract crude drug extract, Vaseline, Beeswax, Cristol and emulsifier 80 It was dissolved at 0 ° C, and then purified water at 80 ° C was gradually added to the oil phase to form a cream.

Example 3 Ointment Manufacturing method Soil and walnut extract crude drug extract, isopropyl myristate, cetanol, paraffin wax, microcrystalline wax, and emulsifier are heated and melted, and purified water heated to 70 ° C or higher is added and stirred, and cooled to 40 ° C while stirring. did.

Claims (1)

(57) [Claims] 1. Alternatively, a hair growth and hair growth stimulating agent containing at least one crude drug extract obtained by extracting a crude drug of Shochiku or walnut meat with a water-soluble organic solvent or a water-containing water-soluble organic solvent.