JP2510552B2 - Hair growth and hair growth promotion charges - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a novel hair growth / hair growth promoter, which is safe without skin irritation.

Conventionally, various compounds, extracts such as crude drugs, etc. have been applied to hair growth and hair growth promoters, but few have significant effects, and those with some effects cause dermatitis. However, the present inventor has obtained the present invention free from such drawbacks as a result of various experimental studies.

The present invention relates to sesame (seed of Ricinus communis L.)
Or Kamala (Mallotus philippinensis MULL-ARG
Glandular and bundle hairs of the fruit epidermis) containing at least one crude drug extract extracted with a water-soluble organic solvent containing 50% by weight or more of a water-soluble organic solvent. The present invention relates to a hair growth and hair growth promoting agent.

As a method for obtaining a hair growth / hair growth promoting agent applied to the present invention, 100 g of a crude drug of sesame or camara, a primary alcohol such as methanol, ethanol, propanol, butanol, or acetone, terahydrofuran, or an organic dioxane is used. Distillation extraction is carried out with the solvent alone or the water-containing organic solvent 1 containing 50% by weight or more of the above primary alcohol or acetone, tetrahydrofuran and dioxane for 2 hours 3 times. These extracts are combined, and after the suction port is passed, the mixture is concentrated to dryness under reduced pressure to remove the solvent to obtain a viscous crude drug extract. The obtained herbal medicine extract is dissolved or dispersed and diluted with an appropriate solvent or the like into a base to obtain the hair growth and hair growth-promoting agent of the present invention.

Here, sesame contained as an active ingredient of the hair growth and hair growth-promoting agent according to the present invention, the content of one or more of the Kamala crude drug extract is 0.1 to 10.0% by weight, preferably 0.5 to 5.0% by weight.
Is.

The hair growth and hair growth-promoting agent containing one or more extracts of crude sesame extract and Kamala extract applied to the present invention is a method for measuring the hair growth density of mice shown in Table 1 below, that is, Test Method I. Shows a remarkable effect as compared with other substances which are said to be hair growth and hair growth promoting agents. This is a result of the components of the crude drug extract extracted from the above crude drug stimulating the hair root, making the blood circulation around the hair ridge more active, and improving the metabolism. Similarly, Table 2 shows the hair-growth and hair-growth-promoting effects of the crude drug extracts of sesame and Kamala extracted with various solvents.

Brief Description of Test Method I Using 9th-week old C3H mice, one group has 10 mice,
Make 4 groups and apply 0.02g of the sample on the next day after removing hair to the area where the hair was removed to an area of 2.0 cm × 2.0 cm on the 9th day, 1
On the 1st and 14th days, the density of hair growth at the site is captured as a degree of increase in blackness using a color difference meter and compared with conventional vitamin E as a comparative substance and 99.5% ethanol solution as a control.

Table-1 Measurement of hair growth density In each sample applied in Table-1, A is a 99.5% ethanol solution containing 2% by weight of vitamin E as a comparative substance, and B and C are crude drug extracts obtained by methanol extraction of sesame and camara, respectively. 5% by weight included 9
9.5% ethanol solution, D is 99.5 as a control
% Ethanol.

Table-2 Measurement of hair growth effect by extraction solvent Measurement method: Same as test method 1 (10 animals per group) As shown in the results of the table, fat-soluble extract fractions of sesame and Kamala, water extraction (including less than 50 wt% of water-soluble organic solvent)
It can be seen that the fraction contains no or almost no components that promote the hair growth effect.

 Next, examples of clinical trials will be shown.

Production example 1 Kara sesame extractable extract 100 g of sesame purchased from the Osaka crude drug market is weighed and made into a coarse powder of about 20 mesh by a crusher, and then 1
Digested with methanol for 2 hours, and then the extract was filtered. The extraction filtrates obtained by repeating this extraction operation three times were combined and the solvent was distilled off under reduced pressure at 40 ° C. to obtain 14.2 g of a viscous dark brown crude drug extract having a peculiar odor.

Production example 2 Kamala extract crude drug extract 100 g of Kamala purchased from Osaka crude drug market was weighed and chopped into pieces of about 5 mm width, and then digested with 70V / V% methanol of 1 for 2 hours, and then the extract Filtered. The extraction filtrates obtained by repeating this extraction operation three times were combined and the solvent was distilled off under reduced pressure at 60 ° C. to obtain 9.2 g of a viscous dark brown crude drug extract having a peculiar odor.

Example 1 As a sample, a 99.5% ethanol solution containing 2% by weight of the crude extract of sesame extract of Production Example 1 was used.

A sample of alopecia areata, a female 44 years old having a hair loss site with a diameter of 3 cm on the occipital region, was applied with 3 to 5 g of the sample once a day once a day. Six months after the occurrence, hair became terminal hair and the hair loss site disappeared.

Example 2 As a sample, a 99.5% ethanol solution containing 2% by weight of a mixture of the sesame extract crude drug extract of Production Example 1 and the Kamala extract crude drug extract of Production Example 2 in a ratio of 1: 1 was used.

A sample of alopecia areata, a 36-year-old male with a 2.5 cm hair loss site on the parietal region and the temporal region, once a day,
When 3 to 5 g was applied at one time, after 3 months, vellus hair was produced at the hair loss site of the crown and temporal region, and after 6 months, vellus hair was produced, but it was not completely cured.

In both Examples 1 and 2, no skin damage due to continuous application for 6 months was observed.

 Next, prescription examples are shown. The mixing ratio is parts by weight.

Example 1 Hair Tonic Kara sesame extract crude drug extract (Production Example 1) 2.0 Menthol 0.2 99.5% ethanol 60.0 Purified water 37.8 Method 99.5% ethanol was dissolved with the sesame extract crude extract and menthol, and then purified water was added. To manufacture.

Example 2 Hair Cream Kamala Extract Crude Drug Extract (Production Example 2) 1.0 Vaseline 7.0 Beeswax 8.0 Cristol 37.0 Emulsifier 5.5 Purified Water 41.5 Method Kamala Extract Crude Drug Extract, Vaseline, Beeswax, Cristol and Emulsifier are mixed at 80 ° C. Dissolve in, and then gradually add purified water at 80 ° C to the oil phase to form a cream.

Example 3 Ointment Kara sesame extract crude drug extract (Production Example 1) 0.5 Kamala extract crude drug extract (Production Example 2) 1.0 Isopropyl myristate 10.0 Cetanol 2.0 Paraffin wax 6.0 Microcristanline wax 10.0 Emulsifier 11.0 Purified water 59.5 Method Kamala extract crude drug extract, isopropyl myristate, cetanol, paraffin wax, microcrystalline wax, and emulsifier are melted by heating. Separately, purified water heated to 70 ° C or higher is added and stirred, and cooled to 40 ° C while stirring.

Claims (1)

(57) [Claims] 1. An extract characterized by containing at least one crude drug extract obtained by extracting a crude drug of sesame or camara with a water-soluble organic solvent or a water-containing water-soluble organic solvent containing 50% by weight or more of a water-soluble organic solvent. Hair and hair growth promotion charges.