JP2938253B2 - Hair growth and hair growth fees - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel hair growth / hair restoration material, and more particularly, to a hair growth / hair restoration having excellent hair growth / hair restoration effects and high safety and stability that can sufficiently withstand long-term use. No fee will be provided.

[0002]

2. Description of the Related Art At present, various hair extract / hair restorations are provided with various extracts of crude drugs or various compounds. For example, as a crude drug extract, extract such as yokuinin, ginkgo and cashew (Japanese Patent Publication No. 1-13451)
JP, JP-A-2-48512, JP-A-2-48
No. 514) and the compounds include vitamin E,
Alloxazine, pyridine N-oxide, adenosine-
3 ', 5'-cyclic monophosphate (Japanese Unexamined Patent Publication No.
4-56608, JP-A-1-261321, JP-A-2-204406).

[0003]

However, the hair growth and hair restoration materials provided so far include, as mentioned in the above examples,
Although various crude drug extracts and various compounds have been applied, there are almost no remarkable effects,
Those having a certain degree of effect have such drawbacks that they are so irritating that they cause dermatitis and that continuous use is difficult. Therefore, an object of the present invention was to develop a hair growth / hair restoration material having excellent hair growth / hair growth effects and having safety and stability enough to withstand long-term use.

[0004]

Means for Solving the Problems The present inventors have conducted intensive studies in order to solve the above-mentioned problems, and as a result, have found that
gundo L.var.cannabifolia: Chinese extract (Thorn) or water extract and / or water-soluble organic solvent is used to extract the extract. The present inventors have found that the above-mentioned problems can be solved, and have reached the present invention.

[0005] That is, the present invention comprises a hair growth / hair growth-promoting component comprising an extract obtained by extracting carrot or Taiwan ginseng with water and / or a water-soluble organic solvent as a hair growth / hair growth promoting component. It is a hair restorer, and in a preferred embodiment, a hair growth / hair restorer having an extract content of 0.001 to 10% by weight as an extract.

Hereinafter, the present invention will be described in detail.

The carrot that is applied to the present invention is a plant belonging to the family Vermiculaceae, Vitex negundo L.var.cannabifolia.
It is known as the Chinese name of the sword, and its origin is mainly in the Indian region. In addition, Taiwan carrot is also a plant of the family Scrophulariaceae, called Vitex negundo L., and the Chinese name is Huang Jing. The fruits of these plants are mainly used for the treatment of cold, and the sap of the root is used as an expectorant.
No examples have been found to verify the hair growth and hair growth effects of these plants, and they have been found for the first time by the present inventors.

The water-soluble organic solvent applied to the present invention is
For example, a single or mixed solvent of a primary alcohol such as methanol, ethanol, propanol and butanol, a polyhydric alcohol such as 1,3-butylene glycol and propylene glycol, or a water-soluble organic solvent such as acetone, tetrahydrofuran and dioxane.

Next, a general method for producing an extract having a hair growth and hair growth-promoting effect from a carrot or a carrot is described. A suitable method is to digest the whole plant, preferably the seeds of the carrot or the carrot, into a water and / or a water-soluble organic solvent by digestion. A common extraction operation is to use 0.5 to 5 liters of a solvent per 100 g of carrot or Chinese ginseng, and at room temperature to the boiling point of the extraction solvent at room temperature.
The digestion extraction is performed once or twice for 10 to 10 days at a heating time of 4 to 8 hours. The extracts are combined, filtered with suction, and then concentrated under reduced pressure to remove the solvent to obtain a viscous or dried extract. These extracts (extracts or extracts) may be used as they are or after dissolving, dispersing and diluting with an appropriate solvent or the like.

[0010] Next, a specific example of the production of a carrot or a carrot extract extract used in the examples will be described. (1) Carrot seeds (100 g) were immersed and extracted in 1 liter of 70% ethanol water at room temperature for 10 days, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract (10% yield). , Hereinafter referred to as extract A). (2) Immerse 100 g of the whole plant of Taiwan ginseng in 1 liter of ethanol, transfer to a Soxhlet extractor, and perform warm extraction for 8 hours. Thereafter, the mixture is cooled and the residue is filtered off with a filter paper, and the filtrate is evaporated to dryness to obtain an extract (yield 7%, hereinafter referred to as extract B). (3) 100 g of Chinese carrot seeds are immersed in 1 liter of acetone, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. Thereafter, the mixture is cooled and the residue is filtered off with a filter paper, and the filtrate is evaporated to dryness to obtain an extract (yield 12%, hereinafter referred to as extract C). (4) 100 g of whole carrot plant is immersed in 1 liter of butanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue is filtered off with filter paper, and the filtrate is evaporated to dryness to obtain an extract (yield 8.5%, hereinafter referred to as extract D). (5) 100 g of carrot seeds are immersed in 1 liter of an extraction solvent of 1,3-butylene glycol: distilled water = 1: 1, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. Thereafter, the mixture is cooled, the residue is filtered off with a filter paper, and the filtrate is evaporated to obtain a viscous extract (yield 8.5%,
Hereinafter referred to as extract E). (6) 100 g of the whole plant of Chinese ginseng was immersed and extracted with 1 liter of water at room temperature for 10 days, the residue was filtered off with filter paper, and the filtrate was evaporated to obtain a viscous extract (yield 7.8). %, Hereinafter referred to as extract F).

[0011] Here, the content of the extract of carrot or Chinese carrot as an active ingredient for promoting hair growth and hair growth according to the present invention is preferably 0.001 to 10% by weight based on the total amount of hair growth and hair growth ingredients. And more preferably 0.05 to 5% by weight. 0.001% by weight
If the concentration is lower, a sufficient hair growth effect is not exhibited in the hair growth test described below, and if the concentration is higher than 10% by weight, the stability of the hair growth / hair growth material itself deteriorates, which is not preferable.

Other raw materials applied to the hair growth and fostering material of the present invention include hydrocarbons, waxes, fats and oils, esters, higher fatty acids, higher fatty acids and the like which are usually applied to the hair growth and fostering material. Alcohols, surfactants, fragrances, dyes, preservatives, antioxidants, ultraviolet protective agents, alcohols, pH regulators, and medicinal ingredients suitable for the purpose of the present invention are appropriately selected and prepared. Furthermore, it can be used in combination with a known and used hair growth and hair growth component. In addition, the hair growth and hair growth agent of the present invention includes various dosage forms such as hair tonic, hair lotion, hair treatment, hair cream, shampoo, rinse,
Pomade and the like.

[0013]

The hair growth / hair restoration of the present invention is an extract of carrot or carrot extract which stimulates hair roots, activates blood circulation around hair follicles, activates metabolism, and promotes hair growth / hair growth. I guess.

[0014]

EXAMPLE First, the effect of the extract on hair growth in mice is tested.

<Experimental Methods and Results> (1) Sample 5% of an extract of carrot or ethanol extract from Carrot which is applied to the present invention 7
A 0% aqueous ethanol dispersion, a 70% aqueous ethanol dispersion containing 1% of vitamin E conventionally known as a component having a hair growth and hair growth effect, and a control,
Four samples of a 70% ethanol aqueous solution of a solvent were used. (2) Hair growth test method using mice This test method uses 9-week-old C3H mice, and makes four groups of 10 mice each, and 2.0 × 2.0
The next day after removing the hair to the site where the hair was removed to the size of
On the 16th day after the application of g, the density of hair growth at the site was determined as the degree of increase in black color (decrease in L value) using a color difference meter.

(3) Effect

[Table 1] As is clear from Table 1, in the 70% aqueous ethanol dispersion containing the carrot or Ginseng extract applied to the present invention, the L value decreases and the black color increases. It can be seen that the effect is remarkable. On the other hand, 70% containing conventional vitamin E
In the aqueous ethanol dispersion, since the decrease in the L value was small, it was found that the hair growth promoting effect was weak. This is presumed to be the result of the extract of carrot or Ginseng radiata of the present invention stimulating hair roots, increasing blood circulation around hair follicles and activating metabolism.

Hereinafter, the hair growth and fostering material of the present invention will be described with reference to examples, but the present invention is not limited to these examples. In addition, the compounding amount is a weight part.

Hair tonics of Examples 1, 2, 3 and Comparative Example 1 (Formulation)

[Table 2]

(Preparation method) Each raw material is placed in a stirring vessel equipped with a heating device, heated and mixed and dissolved at 50 ° C., solubilized to obtain a product.

Next, in order to confirm that the hair growth and hair growth effects of the product of the present invention are remarkable, an actual use test is performed on humans.

<Experimental Methods and Results> (1) Samples Hair Tonic of Examples 1, 2, and 3 and Comparative Example 1 (2) Test Method Twenty panelists of 20 persons complaining of alopecia and alopecia, 4 groups of 5 persons each And a hair growth / hair growth effect test was conducted by using each of the samples for 6 consecutive months for each group. The method of use was to apply it evenly to the head twice a day as in the usual tonic usage. The evaluation was performed on the third and sixth months after the start of use, and the degree of increase in the number of subjects who felt that the naive hair and hard hair had increased was measured. At the end of the test, they also reported on improving their scalp condition and reducing dandruff.

(3) Result

[Table 3] As is clear from Table 3, in the hair tonics of Examples 1, 2, and 3 containing the carrot box extract of the present invention,
The hair growth effect was recognized from the fact that the number of people with naive hair and those with hard hair increased. On the other hand, it was found that the effect was not detected with the hair tonic of Comparative Example 1 containing no carrot extract. Further, at the end of the test, three persons in Example 1 and one person in Example 2 reported that the condition of the scalp was improved and the occurrence of dandruff was reduced.
This indicates that the hair tonic containing the extract of carrots of the present invention has a remarkable hair-growth effect. Furthermore, no skin damage such as deterioration of the scalp condition or inflammatory reaction was observed in any of the panelists during the use test period, confirming that the product of the present invention has high safety. All the hair tonics were stable.

Example 4 Hair Lotion (Formulation)

[Table 4] (Manufacturing method) The raw materials for group A and the raw materials for group B in Table 4 are separately stirred at room temperature and homogeneously dissolved. The solution of the raw material of B is added to the solution of the raw material of A, and C is further added to obtain a product.

Example 5 Hair Treatment (Formulation)

[Table 5] (Manufacturing method) The raw materials for Group A and the raw materials for Group B shown in Table 5 are separately stirred at 80 ° C. and homogeneously dissolved. The solution of A is added to the solution of B and emulsified. The mixture is cooled to 40 ° C. with stirring, C is added, and D is further added to obtain a product.

Example 6 Hair Cream (Formulation)

[Table 6] (Preparation method) The ingredients of Group A in Table 6 were mixed and dissolved at 80 ° C, and then the solution of A was gradually added to the solution of B which had been heated and dissolved at 80 ° C in advance to emulsify. Thereafter, the mixture is cooled to 40 ° C., and D is added to obtain a product.

Example 7 Shampoo (Formulation)

[Table 7] (Production method) The raw materials of Group A in Table 7 were mixed at 80 ° C.
After cooling to 40 ° C., the solution of B is added, and C is further added to obtain a product.

[0027]

EFFECT OF THE INVENTION The hair-growing / hair-growing agent containing the carrot or Ginseng extract of the present invention shows a hair-growing effect in a hair-growing test using mice, and further shows a hair-growing / hair-growing effect in a human use test. Hair growth effect was observed, and no skin damage due to long-term use was observed.

Continuation of the front page (72) Inventor Yukiko Yokoyama 27-1, Takashimadai, Kanagawa-ku, Yokohama-shi, Kanagawa Prefecture Inside of the Yokohama Research Laboratory, Polar Research Inc. (72) Inventor Kakeichiro Yoshihama 27-1, Takashimadai, Kanagawa-ku, Yokohama-shi, Kanagawa (72) Inventor Hideo Kuroda 27-1 Takashimadai, Kanagawa-ku, Kanagawa-ku, Yokohama, Kanagawa Prefecture Inside of Yokohama Research Laboratory (72) Inventor Masami Suzuki Takashima, Kanagawa-ku, Yokohama, Kanagawa No. 27 1 Polar Research & Development Co., Ltd. Yokohama Research Laboratory (58) Field surveyed (Int.Cl. ⁶ , DB name) A61K 7/06 A61K 7/075

Claims (2)

(57) [Claims] 1. A hair growth / hair restoration material comprising an extract obtained by extracting a carrot or a carrot flower with water and / or a water-soluble organic solvent as a hair growth / hair growth promotion component. 2. The hair growth and fostering material according to claim 1, wherein the content of the extract is 0.001 to 10% by weight as an extract.