JPH11171730A - Hair restoring and growing agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a restoring and growing agent having excellent hair restoring and growing effects and stability capable of sufficiently standing use for a long period of time. SOLUTION: This hair restoring and growing agent contains preferably 0.001-10 wt.% of an extracted essence obtained by extracting flowers of Chrysanthemummorifolium Ramat. with a water-soluble organic solvent or a hydrous water-soluble organic solvent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair growth / hair restoration material, and more particularly, to an object of the invention is to provide a hair growth / hair restoration material having excellent hair growth / hair restoration effects and having sufficient safety for long-term use. It is.

[0002]

2. Description of the Related Art Conventionally provided hair growth and hair growth products contain various crude drug extracts or various compounds. For example, crude drug extracts include extracts such as yoquinin and cashew (see Japanese Patent Publication No. 1-13451, JP-A-2-48514, etc.), and compounds such as vitamin E, alloxazine, pyridine N-oxide and adenosine-3. ', 5'-cyclic monophosphate (JP-A-64-56608;
261321, JP-A-2-204406, etc.).

[0003]

However, the hair growth and hair growth materials provided so far include, as mentioned in the above examples,
Various crude drug extracts and various compounds have been applied, but few have a remarkable effect, and those having a certain effect are so stimulating that dermatitis is caused,
There are drawbacks such as difficulty in continuous use.

[0004] The present invention has been made in view of such circumstances, and provides a hair growth and fostering material that is excellent in hair growth and fostering effects and has sufficient safety to withstand long-term use. That is the task.

[0005]

Means for Solving the Problems The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, the extract obtained from chrysanthemum flower, which is the head flower of chrysanthemum, has specifically excellent hair growth and
It has been found that it has a hair-growth effect and has no safety problems during use, and has completed the present invention based on such findings.

[0006] That is, the present invention is characterized in that the extract preferably contains 0.001 to 10% by weight of an extract obtained by extracting chrysanthemum with a water-soluble organic solvent or a water-containing water-soluble organic solvent. Hair growth and hair growth.

[0007] The present invention also relates to a hair growth and fostering material further comprising a skin peripheral vasodilator in the above hair growth and fostering material.

Hereinafter, the present invention will be described in detail. First, chrysanthemum flower applied to the present invention is a chrysanthemum belonging to the family Asteraceae (scientific name: Ch
rysanthemummorifolium Ramat. or Chrysanthemum mori
folium Hemsl.) or its closely related species, which is a dried flower, and has been used in Chinese medicine as a wind fever, etc. by utilizing its anti-inflammatory, urinary and antibacterial effects. In addition, it has been reported that taking hair as a component of foods and the like improves hair growth effect (see Japanese Patent Application Laid-Open No. 61-33123). The present inventors have first found that there is a remarkable hair-growth / hair-growth effect even when directly applied.

Next, in order to obtain the extract according to the present invention from the above chrysanthemum flower, the chrysanthemum flower itself or the crushed one is extracted with a monohydric alcohol such as methanol, ethanol, propanol or butanol, 1,3-butylene. Polyhydric alcohols such as glycol and propylene glycol, or water-soluble organic solvents such as acetone, tetrahydrofuran and dioxane; or water-containing aqueous solutions containing the above monohydric alcohol, polyhydric alcohol or acetone, tetrahydrofuran, dioxane and the like, preferably at least 50% by weight. Extraction is performed using a neutral organic solvent, but it is preferable to use a monohydric alcohol or a polyhydric alcohol.

As a specific method, 100 g of chrysanthemum is used in an extraction solvent of 0.5 to 5 liters at a temperature from room temperature to the boiling point of the extraction solvent, at room temperature for 7 to 10 days, at heating for 4 to 8 hours, and at 1 to 8 hours. 2
Extract once. These extracts are combined, filtered with suction, and then concentrated under reduced pressure to remove the solvent to obtain a viscous or dried extract. The obtained extract is dissolved or dispersed and diluted with an appropriate solvent or the like as it is, and then mixed with a base to obtain the hair growth and hair growth material of the present invention.

Here, the content of the extract of chrysanthemum flower contained as an active ingredient in the hair growth and hair growth agent according to the present invention is preferably 0.001 to 10% by weight, particularly preferably 0.05 to 10% by weight.
5% by weight. When the content is less than 0.001% by weight, the hair growth effect is reduced, and when the content exceeds 10% by weight, the stability is reduced.

Next, the hair growth and hair growth agent of the present invention has a more preferable hair growth and hair growth effect when it contains a skin peripheral vasodilator in addition to the above chrysanthemum flower extract. Such skin peripheral vasodilators include, for example, carpronium chloride, benzyl nicotinate, vitamin E, vitamin E acetate, vitamin E linoleate, vitamin E nicotinate, pepper tincture, etc., and one or more of these. Is used.

[0013] The hair growth and fostering composition of the present invention includes the above-mentioned chrysanthemum flower extract, skin peripheral vasodilator, and normal hair growth / growth.
Additives used in hair restorers, such as hinokitiol, cationic surfactants, bactericides such as parabens, cooling agents such as l-menthol, hydrocarbons, waxes, oils and fats, esters, higher fatty acids, higher alcohols and the like Oils, other surfactants, fragrances, dyes, antioxidants, UV protection agents, alcohols, pH adjusters, water and the like can be added.

The hair growth and hair growth agent of the present invention includes various dosage forms, for example, hair tonic, shampoo, rinse, pomade, hair lotion, hair cream, hair treatment and the like, and is prepared according to a conventional method.

[0015]

BEST MODE FOR CARRYING OUT THE INVENTION Here, a production example of a chrysanthemum flower extract according to the present invention will be described. Production Example 1. 100 g of chrysanthemum flower is immersed in 1 liter of ethanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 3.0%)

Production Example 2 100 g of chrysanthemum flower was immersed and extracted with 1 liter of 70% ethanol at room temperature for 10 days, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract extract. (Yield 3.7%)

Production Example 3 100 g of chrysanthemum flower is immersed in 1 liter of acetone, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.9%)

Production Example 4 100 g of chrysanthemum flowers in 1 l of butanol
, Transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.5%)

Production Example 5 100 g of chrysanthemum flower is immersed in 1 l of an extraction solvent of propylene glycol: distilled water = 1: 1 (weight ratio), transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 3.
2%)

Comparative Production Example 1 100 g of whole dried chrysanthemum
Was extracted by immersion in 1 l of 70% ethanol at room temperature for 10 days, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 3.5%)

Comparative Production Example 2 100 g of chrysanthemum flower was immersed and extracted with 1 l of ethyl acetate at room temperature for 10 days, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 1.6%)

Next, a comparative test was conducted on the effect of the extract of chrysanthemum flower obtained as described above on hair growth in mice.

"Mouse hair growth evaluation test" (1) Sample Invention product 1: 70% aqueous ethanol dispersion containing 5% of Chrysanthemum extract extract (Production example 2) Invention product 2: Chrysanthemum extract extract (Production example 3) )) A 70% aqueous ethanol dispersion containing 5% of an extract of chrysanthemum flower (Preparation Example 4) The present product 3: A chrysanthemum extract extract (Preparation Example 5) containing 5% 70% aqueous ethanol dispersion containing 5% Comparative product 1: 70% aqueous ethanol dispersion containing 1% vitamin E Comparative product 2: 5% chrysanthemum extract (Comparative Production Example 1)
70% ethanol aqueous dispersion containing Comparative product 3: 5% extract of chrysanthemum extract (Comparative Production Example 2)
70% ethanol aqueous dispersion containing: 70% ethanol aqueous solution

(2) Test Method Using 9-week-old C3H mice, 1 group was divided into 10 groups, and 8 groups were formed. Their backs were shaved to a size of 2.0 × 2.0 cm and then removed the next day. After applying 0.04 g of each sample to the hair site,
On the 16th day, the density of hair growth at the site was evaluated as a degree of black increase using a color difference meter. Table 1 shows the results.

[0025]

[Table 1]

As is evident from the results in Table 1, the extract of chrysanthemum flower according to the present invention was compared with the control, vitamin E of comparative product 1, chrysanthemum extract of comparative product 2, and ethyl acetate of chrysanthemum extract of comparative product 3. As a result, it can be seen that the decrease in the L value is large and the blackness is increased. This is presumably because the extract of chrysanthemum flower according to the present invention stimulated hair roots, increased blood circulation around hair follicles, and activated metabolism.

[0027]

The present invention will be further described with reference to the following examples.
In addition, the compounding amount is a weight part. Embodiments 1-3. Hair tonic Using the components and composition shown in Table 2 below, each component was heated and dissolved, and solubilized to prepare a hair tonic.

[0028]

[Table 2]

"Human hair growth / hair growth evaluation test" (1) Sample The present invention product: Hair tonic of Examples 1 to 3 Comparative product: Chrysanthemum flower extract (Production Example 2) was removed from the hair tonic of Example 1 (Increase water) Hair tonic

(2) Test Method Twenty panelists, each complaining of alopecia and alopecia, were divided into 4 groups of 5 each, and a long-term continuous test for 6 months was performed using each sample. The application method was a method of evenly applying the composition to the head twice a day as in the usual tonic usage. The evaluation was performed on the third and sixth months after the start of use, and the degree of increase in the number of test subjects who felt that the hairs and hairs had increased was measured. In addition, at the end of the test, they were asked to improve their scalp condition and reduce dandruff. Table 3 shows the results.

[0031]

[Table 3]

As is evident from the results in Table 3, the hair growth and hair growth preparation of the present invention has a hair growth effect because the number of people who have developed alveoli and those who have hard hair have increased. Was done. At the end of the test, three people in Example 1 and two people in Example 2 reported that the condition of the scalp was improved and the occurrence of dandruff was reduced. From this, the hair growth / hair growth material of the present invention was also confirmed to have a hair growth effect. Furthermore, no skin damage such as deterioration of the scalp condition or inflammatory reaction was observed in any of the panelists during the use test period, confirming that the safety was high.

Embodiment 4 FIG. Hair tonic (A) Chrysanthemum flower extract (Production Example 4) 3.0 Menthol 0.2 Vitamin E 0.05 Carpronium chloride 0.1 (B) Ethanol 50.0 (C) Propylene glycol 5.0 Vitamin B2 0.5 Yeast extract (containing nucleic acid) 0.5 Glycyrrhizin dipotassium 0.3 Diphenhydramine hydrochloride 0.3 Methylparaben 0.2 (D) Purified water 39.75 (E) Fragrance 0.1

(Preparation method) (A) was dissolved in (B), and (D) and (E), in which (C) was dissolved, were added thereto to prepare a hair tonic.

Embodiment 5 Hair treatment (A) Liquid paraffin 2.0 Methyl polysiloxane (10 cs) 2.0 Cetanol 4.0 (B) Stearyltrimethylammonium chloride 3.0 Distearyldimethylammonium chloride 0.5 Chrysanthemum flower extract (Production Example 5) 4.5 Propylene glycol 5.0 Pyrocton olamine 0.25 Purified water 40.0 (C) Hydrolyzed collagen 0.5 Hyaluronic acid 0.01 Bovine placenta extract 0.5 Purified water 37.19 Diphenhydramine hydrochloride 0.25 Methyl paraben 0.2 (D) Fragrance 0.1

(Preparation method) (A) and (B) were each heated to 80 ° C.
And emulsify by mixing them. Thereafter, the mixture was cooled to around 40 ° C., at which point (C) was added, and further (D) was added to prepare a hair treatment.

Embodiment 6 Hair shampoo (A) triethanolamine lauryl sulfate 10.0 sodium lauryl sulfate 5.0 coconut oil diethanolamide 2.0 propylene glycol 5.0 pyrocton olamine 0.25 benzyl nicotinate 0.1 Chrysanthemum flower extract (Production Example 3) 1.0 (B) trichlorocarbanilide 0.25 purification Water 76.3 (C) Fragrance 0.1

(Preparation method) (A) was mixed at 80 ° C., then cooled to about 40 ° C., (B) was added, and (C) was further added to prepare a hair shampoo.

Embodiment 7 Hair rinse (A) Liquid paraffin 0.5 Methylpolysiloxane (10 cs) 0.5 Cetanol 2.0 Stearyltrimethylammonium chloride 3.0 (B) 1,3-butylene glycol 5.0 Chrysanthemum flower extract (Production Example 2) 2.0 Purified water 40.0 Diphenhydramine hydrochloride 0.25 (C) Glycyrrhizin Dipotassium 0.25 Purified water 46.4 (D) Fragrance 0.1

(Preparation method) Each of (A) and (B) was
And mixed at that point. Thereafter, the mixture was cooled to around 40 ° C., (C) was added, and (D) was further added to prepare a hair rinse.

Embodiment 8 FIG. Hair cream (A) Chrysanthemum flower extract (Production example 1) 2.5 Vaseline 7.0 Beeswax 8.0 Liquid paraffin 37.0 Polyoxyethylene (20E.O.) cetyl ether 3.0 Glyceryl monostearate 2.0 Vitamin E nicotinate 0.1 (B) Purified water 34.6 Propylene glycol 5.0 Diphenhydramine hydrochloride 0.2 Glycyrrhizin dipotassium 0.2 Ethyl paraben 0.3 (C) Fragrance 0.1

(Preparation method) (A) was mixed and dissolved at 80 ° C., and then (B) preheated to 80 ° C. was gradually added to (A) and emulsified. Thereafter, the mixture was cooled to 40 ° C., and (C) was added to prepare a hair cream.

(Preparation method) (A) was dissolved in (B), and (D) and (E), in which (C) was dissolved, were added thereto to prepare a hair tonic.

The hair growth and hair growth effects of the present invention obtained in Examples 4 to 8 above were tested for hair growth and hair growth effects by the same method as in Examples 1 to 3 or a method similar thereto. No skin damage such as deterioration of the scalp condition and inflammatory reaction was observed at all.

[0045]

According to the present invention, it is possible to provide a hair-growth / hair-growing agent which has an excellent hair-growth / hair-growth effect and which is free from skin disorders due to long-term continuous use and which is excellent in safety.

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Hideo Kuroda 560 Pola, Kashio-cho, Totsuka-ku, Yokohama-shi, Kanagawa Prefecture Inside the Totsuka Research Laboratories Co., Ltd. Industrial Co., Ltd.

Claims (3)

[Claims] 1. A hair growth and fostering agent comprising an extract obtained by extracting a chrysanthemum flower with a water-soluble organic solvent or a water-containing water-soluble organic solvent. 2. An extract having a content of 0.001 to 10
3% by weight.
Hair restoration. 3. The hair growth / hair restoration composition according to claim 1, wherein the hair growth / growth material contains a skin peripheral vasodilator.