JP2002234812A - Cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic having excellent beautiful skin effect on the skin by improvement of drying feeling, chapped skin, etc., having hair growth/ hair restoration effect on the hair by promoting hair growth/hair restoration, etc., and having safety capable of sufficiently standing a long-term use. SOLUTION: This cosmetic comprises an extract of Eriodictyon sp., obtained by extracting a plant of Eriodictyon sp., preferably with a water-soluble organic solvent or a hydrous water-soluble organic solvent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to cosmetics, and more particularly to cosmetics, which are excellent in skin-beautifying effects by improving dryness and rough skin on the skin. -It provides cosmetics with an excellent hair-growth effect.

[0002]

2. Description of the Related Art Various herbal extracts have been blended into cosmetics. For example, in the case of skin cosmetics, placenta extract, extract such as yoquinin, Japanese gourd, bukuro, etc. (JP-A-57-31604, JP-A-59-73509, and JP-A-59-73509) have been used in skin cosmetics for the purpose of preventing rough skin and improving wrinkles. Japanese Patent Application Laid-Open (JP-A) No. 60-78910 and the like, and extracts for hair growth and hair growth, such as yoquinin and cashew, for the purpose of hair-growth effect (Japanese Patent Publication No. 1-13451, JP-A-2-48514). See)).

[0003]

However, as mentioned in the above examples, various herbal extracts have been applied to the cosmetics provided so far, but few of them show a remarkable effect. In addition, those having a certain effect have such drawbacks that they are so irritating that dermatitis is caused and that continuous use is difficult.

[0004] The present invention has been made in view of such circumstances, and is excellent in the skin beautiful effect by improving the dry feeling, rough skin, etc. on the skin.
It is an object of the present invention to provide a cosmetic composition which is excellent in hair growth and hair growth effects such as hair growth promotion and has sufficient safety for long-term use.

[0005]

Means for Solving the Problems The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, an extract obtained from a specific plant belonging to the family Paramecium has an excellent skin-beautifying effect on the skin. On the other hand, excellent hair growth and
It has been found that it has a hair-growth effect and has no safety problems during use, and has completed the present invention based on such findings.

[0006] That is, the present invention relates to an extract obtained by extracting a plant of Eriodictyon sp. With a water-soluble organic solvent or a water-containing water-soluble organic solvent. It relates to a cosmetic characterized in that it is contained in a range of 10% by weight. Also, the present invention
Preferably, the present invention relates to a cosmetic further containing a peripheral blood flow promoting agent. Further, the cosmetic of the present invention is suitable as a hair growth / hair restoration.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail.

First, Eriodictyon (Eriodictyon sp.) Applied to the present invention is an annual or perennial plant belonging to the family Perifloridae distributed in tropical and subtropical areas such as Mexico and tropical America. Until now, Eriodiction was known to be used as a drug for diabetes and hypertension, but has not been applied practically from an external point of view. The fact that there is a hair growth effect has been found for the first time by the present inventors.

[0009] The above-mentioned plant of Eriodiction has
Since an ingredient that activates the original function of the skin is contained, when an eriodiction extract is blended with the cosmetic, a cosmetic exhibiting an excellent skin beautiful effect and a hair growth and hair growth effect can be obtained. In addition, the said beautiful skin means that the skin in a defective state such as dry skin or rough skin is improved to the extent that it can be confirmed from the appearance. Further, the above-mentioned hair growth / hair growth refers to a state where hair is growing, for example, hair growth for newly growing hair, growing hair growing, or maintaining a state where hair is growing. The concept includes hair growth and the like, and it is sufficient that at least one of the above-described hair growth and hair growth is exhibited.

Next, in order to obtain the extract of the present invention from the above eriodiction, the whole tissue constituting the plant or each part of the plant which is a part thereof, preferably leaves, stems or whole plants, is dried. Or as it is, crushed
Extraction solvents such as methanol, ethanol, propanol, monohydric alcohols such as butanol, 1,3-butylene glycol, polyhydric alcohols such as propylene glycol, or acetone, tetrahydrofuran, water-soluble organic solvents such as dioxane, or the monohydric alcohol, Extraction is preferably performed using a water-containing water-soluble organic solvent containing preferably at least 50% by weight of polyhydric alcohol or acetone, tetrahydrofuran, dioxane, etc., and further using a water-insoluble organic solvent such as hexane, heptane, cyclohexane, ethyl acetate, etc. It is preferable to use a water-soluble organic solvent or a water-containing water-soluble organic solvent.

As a specific method for obtaining the cosmetic according to the present invention, for example, 100 g of eriodiction is used at a temperature between room temperature and the boiling point of the extraction solvent in a range of 4 to 5 L using 0.5 to 5 L of an extraction solvent. 10 days, heating 4-8 hours, 1-2
Extract once. These extracts are combined, filtered with suction, and then concentrated under reduced pressure to remove the solvent to obtain a viscous or dried extract. The obtained extract is dissolved or dispersed or diluted with an appropriate solvent or the like as it is, and then mixed with a base to obtain the cosmetic of the present invention.

[0012] Here, the content of the eriodiction extract according to the present invention is preferably 0.1 to the entire cosmetic.
001 to 10% by weight, particularly preferably 0.01 to 5% by weight. If the content is less than 0.001% by weight, the effects intended in the present invention will not be sufficiently exerted.
If the amount exceeds the weight percentage, the stability of the cosmetic may decrease depending on the dosage form.

Next, when the cosmetic of the present invention is used as a hair growth and hair growth agent, a more preferable hair growth and hair growth effect can be obtained by adding a peripheral blood flow promoting agent in addition to the above-mentioned eriodiction extract. Have. In addition, the peripheral blood flow promoting agent may be a substance having an action of promoting blood flow in peripheral blood vessels by expanding a blood vessel wall, or may suppress the generation of lipids and the like that deteriorate blood flow in peripheral blood vessels. By doing so, a substance that strengthens the blood vessel wall and restores the original vasomotor function may be used. Examples of such a peripheral blood flow promoting agent include carpronium chloride, benzyl nicotinate, vitamin E, vitamin E acetate, vitamin E linoleate,
Vitamin E nicotinate, pepper tincture, and the like, and one or more of these are used.

The cosmetic of the present invention may be used in ordinary skin cosmetics and hair growth / hair restoration as required, in addition to the above-mentioned eriodiction extract and peripheral blood flow promoter. Various components and additives such as inorganic pigments, organic pigments, inorganic powders, organic powders, hydrocarbons, waxes, fats and oils, esters, higher fatty acids, higher alcohols, triglycerides, lanolins, waxes , Animal and vegetable oils,
Silicones, surfactants, polyhydric alcohols, sugars, vitamins, amino acids, cooling agents, antioxidants, preservatives / bactericides, fragrances, thickeners, UV protection agents, alcohols, pH adjusters and Water and the like can be blended.

The cosmetic of the present invention includes various dosage forms. Examples of the skin cosmetic include a lotion, an emulsion, a cream, a pack, a foundation, a lipstick, and the like.
In addition, hair tonic, shampoo,
Rinsing, pomade, hair lotion, hair cream, hair treatment and the like can be mentioned, and are prepared according to a conventional method.

Here, a production example of the eriodiction extract according to the present invention will be described. (Production Example 1) Whole plant dried product of Eriodiction 100
g of methanol at room temperature for 4 days, and the residue was filtered off with filter paper. The filtrate was evaporated to dryness.
An extract was obtained. (3.6% yield)

(Production Example 2) 100 g of dried whole plant of Eriodiction was treated with 2 L of 70% ethanol at room temperature for 10 hours.
Extraction was performed by immersion for one day, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.8%)

(Production Example 3) 100 g of dried whole plant of eriodiction is immersed in 2 L of acetone, transferred to a Soxhlet extractor, and subjected to heating extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.4%)

(Production Example 4) 100 g of dried whole plant of eriodiction is immersed in 2 L of butanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.1%)

(Production Example 5) 100 g of dried whole plant of Eriodiction was propylene glycol: distilled water = 1:
1 is immersed in 2 L of the extraction solvent, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 1.8%)

(Production Example 6) 100 g of dried whole plant of eriodiction was immersed and extracted with 2 L of ethyl acetate at room temperature for 10 days, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness and extracted. I got something. (Yield 1.3%)

Next, the results of tests conducted to demonstrate how the cosmetics of the present invention are excellent in terms of a beautiful skin effect and hair growth and hair growth effects will be described.

1. Skin beauty effect test (1) Sample The present invention product: lotion of Example 1 described later Comparative product 1: lotion prepared by replacing the eriodiction extract in the lotion of Example 1 described below with a placenta extract Comparative product 2: The lotion from which the eriodiction extract was removed (the amount of water was increased) in the lotion of Example 1 described later.

(2) Test method Forty-five Japanese adult women with dry skin were randomly divided into three groups (groups A to C), each having 15 persons. The lotion of the present invention product is applied to the face of Group A, the lotion of Comparative Product 1 is applied to the face of Group B, and the lotion of Comparative Product 2 is applied to the face of Group C.
Applied for a week. A comparison was made between the groups on the state of improvement in dry feeling after 4 weeks and the state of spontaneous deterioration (the state in which skin drying progresses despite the application of the above-mentioned lotion). Also,
Regarding the evaluation of the rough skin condition, the stratum corneum was isolated from the facial skin by a tape stripping method, and the method was described in JP-A-63-1133.
According to the method described in JP-A-58-58, the stratum corneum was observed by an optical microscope, and the degree of delamination and the presence or absence of nucleated cells were evaluated in five steps. The results are shown in Tables 1 and 2.

[0025]

[Table 1]

[0026]

[Table 2]

As shown in the results of Tables 1 and 2, the lotion of the product of the present invention has a remarkable improvement in dry feeling and skin roughness as compared with the lotion of the comparative product, and has an excellent skin effect. Has been demonstrated. In addition, as an opinion other than the above evaluation factors, it was also clarified that the cosmetic of the present invention had no adverse effects on safety such as irritation and skin irritation during use.

2. Hair growth and hair growth effect test "Mouse hair growth evaluation test" (1) Sample The present invention product: 70% ethanol aqueous dispersion containing 5% of eriodaction extract (Production Example 2) Comparative product: Vitamin E 1% 70% ethanol aqueous dispersion containing: 70% ethanol aqueous solution

(2) Test method Using C3H mice of 9 weeks old, one group consisted of 10 mice, and three groups were formed. The backs of these groups were shaved to a size of 2.0 × 2.0 cm and then removed the next day. After applying 0.04 g of each sample to the hair site,
On the 20th day, the density of hair growth at the site was evaluated as a degree of black increase using a color difference meter. Table 3 shows the results.

[0030]

[Table 3]

As is apparent from the results in Table 3, the eriodiction extract according to the present invention has a lower L value and an increased blackness as compared with the control. On the other hand, the vitamin E of the comparative product showed only a small decrease in the L value compared to the control of the present invention. This is presumed to be the result of the eriodiction extract according to the present invention stimulating the hair root, increasing blood circulation around the hair follicle, and activating metabolism.

"Human hair growth / hair growth evaluation test" (1) Sample The present invention product: Hair tonic of Examples 7 to 9 described below Comparative product: Erio diction extract from hair tonic of Example 7 described below (Production Example 2) Hair tonic without water (increased water)

(2) Test Method Twenty panelists complaining of alopecia and alopecia were divided into 4 groups of 5 each, and a long-term continuous test for 6 months was performed using each sample. The application method was a method of evenly applying the composition to the head twice a day as in the usual tonic usage. The evaluation was performed at the third and sixth months after the start of use, and the number of subjects who felt that the amount of downy hair and hard hair had increased was measured. In addition, at the end of the test, they were asked to improve their scalp condition and reduce dandruff. Table 4 shows the results.

[0034]

[Table 4]

As is clear from the results shown in Table 4, the hair growth and fostering material of the present invention shows that hair growth is caused by the increase in at least one of those who have naive hair and those who have hard hair. -Hair growth effect was observed. At the end of the test, the number of persons who reported improvement in the condition of the scalp and reduction in the occurrence of dandruff was 4 in Example 7 and 2 in Example 8. From this, the effect of improving the condition of the scalp was also recognized in the hair growth and fostering material of the present invention. Furthermore, no skin damage such as deterioration of the scalp condition or inflammatory reaction was observed in any of the panelists during the use test period, confirming that the safety was high.

[0036]

Examples of the present invention will be described below. The mixing ratio is part by weight.

[0037]

Example 1 Lotion (A) Purified water 78.89 Glycerin 5.0 Propylene glycol 4.0 (B) POE (20) Sorbitan monolaurate 1.5 POE (20) Lauryl ether 0.5 Ethanol 10 0.0 Eriodiction extract (Production Example 2) 0.01 Fragrance 0.1

(Preparation method) The components of (A) are combined and dissolved at room temperature. On the other hand, each component of (B) is also dissolved at room temperature, and is added to (A) formulation and solubilized.

[0039]

Example 2 Emulsion (A) POE (20) hydrogenated castor oil 1.5 coconut oil fatty acid monoglyceride 1.0 oleic acid triglyceride 7.5 (B) glycerin 2.5 eriodiction extract (Production Example 1) 1.0 Refined water 86.3 (C) Fragrance 0.2

(Preparation method) According to each component of (A), heat and mix to 70 ° C. Combine each component of (B) and add 7
Heat and mix at 0 ° C, add the (A) formulation to this, emulsify,
Add (C) while cooling.

[0041]

Example 3 Hand Cream (A) Vaseline 18.0 Cetanol 8.0 POE (20) Oleyl Ether 1.4 Sorbitan Monostearate 0.8 (B) Preservative 0.3 Eriodiction Extract (Production) Example 4) 0.5 Refined water 70.8 (C) Fragrance 0.2

(Preparation method) The same method as in Example 2 was used.

[0043]

Example 4 Cream (A) POE (30) Cetyl ether 2.0 Glycerin monostearate 10.0 Liquid paraffin 10.0 Vaseline 4.0 Cetanol 5.0 Preservative 0.2 (B) Propylene glycol 10 2.0 Eriodiction extract (Production Example 5) 2.0 Refined water 56.8

(Preparation method)
Heat to 0 ° C. Combine the components of (B) and heat to 80 ° C. While stirring the prescription of (A), the prescription of (B) is added thereto to stir and emulsify, followed by cooling.

[0045]

Example 5 Packing material (A) Polyvinyl alcohol 15.0 Purified water 40.0 (B) Bisabolol 0.5 γ-Tocopherol 0.02 Ethanol 4.0 Eriodiction extract (Production example 3) 4.0 POE (8) Polyoxypropylene glycol (55) 3.0 Refined water 33.48

(Preparation method) (A) is dispersed and dissolved at room temperature. (B) is added thereto and uniformly dissolved.

[0047]

Example 6 Gel cosmetic oil (A) Sucrose fatty acid ester 5.0 (Daiichi Kogyo Seiyaku DK Ester F-160) (B) 1,3-butylene glycol 10.0 Glycerin 24.0 Purified water 4 0.5 Preservative 0.3 (C) Liquid paraffin 20.0 Olive oil 30.0 2-Ethylhexanoic acid triglyceride 5.0 Eriodiction extract (Production Example 6) 1.0 (D) Flavor
0.2

(Preparation method)
Heat to 0-80 ° C. and dissolve (A) in this. To this, the prescription of (C) is added, and when cooled to 40 ° C., (D) is added and then cooled.

[0049]

Examples 7 to 9 Hair tonics Using the components and composition shown in Table 5 below, each component was heated and dissolved and solubilized to prepare a hair tonic.

[0050]

[Table 5]

[0051]

Example 10 Hair Tonic (A) Eriodiction Extract (Production Example 4) 3.0 Menthol 0.2 Vitamin E 0.05 Carpronium Chloride 0.1 (B) Ethanol 50.0 (C) Propylene Glycol 5 0.0 Vitamin B2 0.5 Yeast extract (containing nucleic acid) 0.5 Glycyrrhizin dipotassium 0.3 Diphenhydramine hydrochloride 0.3 Methylparaben 0.2 (D) Purified water 39.75 (E) Flavor 0.1

(Preparation method) (A) is dissolved in (B),
To this was added (D) and (E) in which (C) was dissolved to prepare a hair tonic.

[0053]

Example 11 Hair Treatment (A) Liquid Paraffin 2.0 Methylpolysiloxane (10 cs) 2.0 Cetanol 4.0 Eriodiction Extract (Production Example 5) 4.5 (B) Stearyl Trimethylammonium Chloride 3. 0 Distearyldimethylammonium chloride 0.5 Propylene glycol 5.0 Pyrocton olamine 0.25 Purified water 40.0 (C) Hydrolyzed collagen 0.5 Hyaluronic acid 0.01 Bovine placenta extract 0.5 Purified water 37 .19 diphenhydramine hydrochloride 0.25 methyl paraben 0.2 (D) fragrance 0.1

(Production method) (A) and (B)
Heat to 0 ° C., mix and emulsify both. Then 40 ° C
After cooling to the vicinity, (C) was added at that point, and (D) was further added to prepare a hair treatment.

[0055]

Example 12 Hair Shampoo (A) Triethanolamine Lauryl Sulfate 10.0 Sodium Lauryl Sulfate 5.0 Coconut Oil Diethanolamide 2.0 Propylene Glycol 5.0 Pirocton Olamine 0.25 Benzyl Nicotinate 0.1 Elio Diction extract (Production Example 3) 1.0 (B) Trichlorocarbanilide 0.25 Purified water 76.3 (C) Fragrance 0.1

(Preparation method) (A) was mixed at 80 ° C., then cooled to about 40 ° C., (B) was added, and (C)
Was added to prepare a hair shampoo.

[0057]

Example 13 Hair rinse (A) Liquid paraffin 0.5 methylpolysiloxane (10 cs) 0.5 Cetanol 2.0 Stearyltrimethylammonium chloride 3.0 Eriodiction extract (Preparation example 2) 2.0 (B) 1,3-butylene glycol 5.0 Purified water 40.0 Diphenhydramine hydrochloride 0.25 (C) Glycyrrhizin dipotassium 0.25 Purified water 46.4 (D) Fragrance 0.1

(Preparation method) (A) and (B) were
Warm to ° C., at which point mix and emulsify. Then 4
After cooling to about 0 ° C., (C) was added, and (D) was further added to prepare a hair rinse.

[0059]

Example 14 Hair Cream (A) Eriodiction Extract (Preparation Example 1) 2.5 Vaseline 7.0 Beeswax 8.0 Liquid Paraffin 37.0 Polyoxyethylene (20E.O.) Cetyl Ether 3.0 Glyceryl monostearate 2.0 Vitamin E nicotinate 0.1 (B) Purified water 34.6 Propylene glycol 5.0 Diphenhydramine hydrochloride 0.2 Glycyrrhizin dipotassium 0.2 Ethyl paraben 0.3 (C) Fragrance 0.1

(Preparation method) (A) was mixed and dissolved at 80 ° C.
Next, (B) previously heated to 80 ° C. was gradually added to (A) to form a cream. Then cool down to 40 ° C,
(C) was added to prepare a hair cream.

[0061]

Example 15 Hair tonic (A) Eriodiction extract (Preparation example 6) 0.5 Salicylic acid 0.3 Menthol 0.2 Pepper tincture 0.01 (B) Ethanol 60.0 (C) Glycerin 5.0 (D) Purified water 33.89 (E) Fragrance 0.1

(Preparation method) (A) is dissolved in (B),
To this was added (D) and (E) in which (C) was dissolved to prepare a hair tonic.

The hair growth and hair growth effects of the present invention obtained in Examples 10 to 15 were tested for hair growth and hair growth effects in the same manner as in Examples 7 to 9, and all were excellent. No skin damage such as deterioration of the scalp condition and inflammatory reaction was observed at all.

[0064]

According to the present invention, of course, the beautiful skin effect such as improvement of skin condition such as rough skin is remarkably superior to conventionally known skin roughening agents and the like.
It is possible to use cosmetics that have excellent hair growth and hair growth effects, do not cause skin damage due to long-term continuous use, and have no adverse effects on safety.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 NR 7/06 7/06 7/075 7/075 7/08 7 / 08 35/78 35/78 C A61P 17/14 A61P 17/14 (72) Inventor Mayumi Shishido 560 Kashio-cho, Totsuka-ku, Yokohama-shi, Kanagawa Prefecture Inside the Toka Kasei Kogyo Co., Ltd. (72) Inventor Takashi Takada Chiba 1144, Togo, Mobara City, Mitsui Chemicals Stock Company In-house (72) Inventor Fuminobu Yoshimi 1144, Togo, Mobara City, Chiba Prefecture Mitsui Chemicals Stock Company In-house F-term (reference) 4C083 AA072 AA082 AA111 AA112 AA122 AC012 AC022 AC072 AC102 AC122 AC182 AC242 AC422 AC432 AC442 AC472 AC482 AC552 AC642 AC692 AC782 AC812 AC852 AD112 AD152 AD222 AD332 AD432 AD472 AD532 AD632 AD662 BB53 CC04 CC05 CC07 CC32 CC33 CC37 CC38 CC39 DD23 DD27 DD31 DD41 EE22 4C088 AB1 2 AC01 AC05 BA08 BA10 CA03 MA02 MA03 MA17 MA22 MA63 NA14 ZA92 ZC02

Claims (5)

[Claims] (1) Eriodictyon s
A cosmetic comprising the plant extract of p.). 2. The cosmetic according to claim 1, wherein the extract is extracted from the plant with a water-soluble organic solvent or a water-containing water-soluble organic solvent. 3. The content of the extract is from 0.001 to 10
The cosmetic according to any one of claims 1 and 2, which is in terms of% by weight. 4. The cosmetic according to claim 1, wherein the cosmetic is a hair growth / hair restoration. 5. The cosmetic according to claim 4, further comprising a peripheral blood flow promoting agent.