JPH0948712A - Hair growing and fostering agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a new hair growing and fostering agent excellent in hair growing and fostering effect and having safety sufficiently tolerable for a long term use by using an extract obtained from a specific plant belonging to the family Plantaginaceae. SOLUTION: This hair growing and fostering agent is prepared by using an extract obtained by extracting plantain with a water soluble organic solvent such as methanol or ethanol, or a water containing organic solvent such as acetone. The content of the extract is preferably 0.001-10wt.%. The addition of a skin peripheral vasodilator such as vitamin E or nicotinic acid benzyl ester to the hair growing and fostering agent exhibits further preferable hair growing and fostering effect. The hair growing and fostering agent is e.g. a hair tonic, a shampoo, a rinse, a pomade, a hair lotion or a hair cream.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel hair growth / hair restoration material, and more particularly, to provide a hair growth / hair restoration material having excellent hair growth / hair growth effects and having sufficient safety to withstand long-term use. Is what you do.

[0002]

2. Description of the Related Art Conventionally provided hair growth and hair growth products contain various crude drug extracts or various compounds. For example, crude drug extracts include extracts such as yoquinin and cashew (see Japanese Patent Publication No. 1-13451, JP-A-2-48514, etc.), and compounds such as vitamin E, alloxazine, pyridine N-oxide and adenosine-3. ', 5'-cyclic monophosphate (JP-A-64-56608,
1-261321, JP-A-2-204406, etc.).

[0003]

However, the hair growth and hair growth materials provided so far include, as mentioned in the above examples,
Various crude drug extracts and various compounds have been applied, but few have a remarkable effect, and those having a certain effect are so stimulating that dermatitis is caused,
It has drawbacks such as difficulty in continuous use.

[0004] The present invention has been made in view of such circumstances, and provides a hair growth and fostering material that is excellent in hair growth and fostering effects and has sufficient safety to withstand long-term use. That is the task.

[0005]

Means for Solving the Problems The inventors of the present invention have conducted extensive studies to solve the above problems, and as a result, an extract obtained from a specific plant belonging to the psyllium family has excellent hair growth and hair growth effects. The present invention has been found to have no safety problem during use, and the present invention has been completed based on such findings.

That is, the present invention is characterized in that it preferably contains 0.001 to 10% by weight of an extract obtained by extracting from psyllium with a water-soluble organic solvent or a water-containing water-soluble organic solvent. Regarding hair growth and hair restoration materials.

[0007] The present invention also relates to a hair growth and fostering material further comprising a skin peripheral vasodilator in the above hair growth and fostering material.

Hereinafter, the present invention will be described in detail. First, psyllium (scientific name: Plantago lanceolat applied to the present invention
a, Plantago major, etc.) is a perennial plant belonging to the plantain family, which is distributed in about 200 species in the world, including the east coast, west coast of the United States, Canada, and Europe. Up to now, psyllium was used as a medicine because it has sputum, hemostasis, and diuretic effects, and as a cosmetic, leaf extract has been used for acne skin creams and lipsticks because it has the effect of relieving astringency and pain. In some cases, it has never been used as a hair ingredient,
Further, no example of verifying the hair growth / hair growth effect was found, and it was first discovered by the present inventor.

Next, as a method for obtaining the hair-growth / hair-growth material of the present invention using the above psyllium, 100 g of psyllium is
For example, primary alcohols such as methanol, ethanol, propanol and butanol, polyhydric alcohols such as 1,3-butylene glycol and propylene glycol, or water-soluble organic solvents such as acetone, tetrahydrofuran and dioxane alone, or the above primary alcohols and polyhydric alcohols. Alternatively, 0.5 to 5 liters of a water-containing water-soluble organic solvent containing preferably 50% by weight or more of acetone, tetrahydrofuran and dioxane is used, and the temperature is from room temperature to the boiling point of the extraction solvent, at room temperature for 7 to 10 days, and at heating 4 to 8 hours, 1-2
Extract by digestion once.

These extracts are combined, suction filtered and then concentrated under reduced pressure to remove the solvent to obtain a viscous or dry extract. The obtained extract is dissolved or dispersed and diluted with an appropriate solvent or the like as it is, and then mixed with a base to obtain the hair growth and hair growth material of the present invention.

The content of the psyllium extract contained as an active ingredient of the hair-growth and hair-growth agent according to the present invention is preferably 0.001 to 10% by weight, particularly preferably 0.
0.5 to 5% by weight. When the content is less than 0.001% by weight, the hair growth effect is reduced, and when the content exceeds 10% by weight, the stability is reduced.

Next, the hair growth and hair growth agent of the present invention has a more preferable hair growth and hair growth effect when it contains a skin peripheral vasodilator in addition to the above plantain extract.
Examples of such skin peripheral vasodilators include carpronium chloride, benzyl nicotinate, vitamin E, vitamin E acetate, vitamin E linoleate, vitamin E.
Nicotinate, capsicum tincture, etc. may be mentioned, and one or more of them may be used.

Further, the hair growth / hair growth agent of the present invention includes, in addition to the psyllium extract and the skin peripheral vasodilator described above, additives usually used in hair growth / hair growth agents such as hinokitiol, cationic surfactants, and parabens. Bactericide such as 1-menthol, cooling agent such as l-menthol, hydrocarbons, waxes, oils and fats, esters, oils such as higher fatty acids and higher alcohols, other surfactants, fragrances, pigments, antioxidants, UV protection Agent,
Alcohols, pH adjusters, water and the like can be added.

The hair growth and hair growth agent of the present invention includes various dosage forms, for example, hair tonic, shampoo, rinse, pomade, hair lotion, hair cream, hair treatment and the like, and is prepared according to a conventional method.

[0015]

BEST MODE FOR CARRYING OUT THE INVENTION Here, a production example of the psyllium extract according to the present invention will be shown. Production Example 1. 100 g of dried psyllium whole plant was immersed and extracted with 1 liter of 70% ethanol for 10 days at room temperature, the residue was filtered off with a filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.6%)

Production Example 2 100 g of dried whole plant of psyllium
Is immersed in 1 liter of ethanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 3.5%)

Production Example 3 100 g of dried whole plant of psyllium
Dipped in 1 liter of acetone and transferred to a Soxhlet extractor,
Perform warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.3%)

Production Example 4 100 g of dried whole plant of psyllium
Is immersed in 1 liter of butanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.2%)

Production Example 5 100 g of dried whole plant of psyllium
Is propylene glycol: distilled water = 1: 1 extraction solvent 1
Immerse in l, transfer to a Soxhlet extractor, and heat extraction to 8
Do on time. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract.
(Yield 2.2%)

Next, a test was carried out on the effect of the psyllium extract obtained as described above on hair growth in mice.

"Mouse Hair Growth Evaluation Test" (1) Sample This invention: 5% of psyllium extract (Production Example 2)
70% ethanol aqueous dispersion containing Comparative product: 70% ethanol aqueous dispersion containing 1% vitamin E Control: 70% ethanol aqueous solution

(2) Test method Using 9-week-old C3H mice, one group consisting of 10 mice was made into 3 groups, and the backs of these groups were shaved to a size of 2.0 × 2.0 cm, and then removed on the next day. After applying 0.04g of each sample to the hair part,
On the 16th day, the density of hair growth at the site was evaluated as a degree of black increase using a color difference meter. Table 1 shows the results.

[0023]

[Table 1]

As is clear from the results shown in Table 1, it is understood that the L plank extract of the present invention has a decreased L value and an increased blackness. On the other hand, the comparative product Vitamin E
In, the decrease of L value was hardly recognized. It is speculated that this is the result of the psyllium extract according to the present invention stimulating the hair root, making the blood circulation around the hair follicle more active, and activating the metabolism.

[0025]

【Example】

Hereinafter, the present invention will be further described with reference to examples. In addition, the compounding amount is a weight part. Embodiments 1-3. Hair tonic Using the components and composition shown in Table 2 below, each component was heated and dissolved, and solubilized to prepare a hair tonic.

[0026]

[Table 2]

"Human Hair Growth / Hair Growth Evaluation Test" (1) Sample Product of the present invention: hair tonic of Examples 1 to 3 Comparative product: psyllium extract (Production Example 2) was removed from the hair tonic of Example 1. (Increase water) Hair tonic

(2) Test method Twenty panelists who complain of thinning hair and alopecia were divided into four groups of five people each, and a long-term continuous test for 6 months was carried out using each sample. The application method was a method of evenly applying the composition to the head twice a day as in the usual tonic usage. The evaluation was performed on the third and sixth months after the start of use, and the degree of increase in the number of test subjects who felt that the hairs and hairs had increased was measured. In addition, at the end of the test, they were asked to report their scalp condition and reduce dandruff. Table 3 shows the results.

[0029]

[Table 3]

As is clear from the results shown in Table 3, the hair-growth / hair-growth agent of the present invention has a hair-growth effect because the number of people who have bristles and bristles has increased. Was given. At the end of the test, the condition of the scalp was improved, and the number of persons who declared reduction of the occurrence of dandruff was 3 in Example 1 and 1 in Example 2. From this, the hair growth / hair growth material of the present invention was also confirmed to have a hair growth effect. Furthermore, no skin damage such as deterioration of the scalp condition or inflammatory reaction was observed in any of the panelists during the use test period, confirming that the safety was high.

Example 4. Hair tonic (A) Plantain extract (Production Example 2) 3.0 Menthol 0.2 Vitamin E 0.05 Carpronium chloride 0.1 (B) Ethanol 50.0 (C) Propylene glycol 5.0 Vitamin B2 0.5 Yeast extract (containing nucleic acid) 0.5 Glycyrrhizin dipotassium 0.3 Diphenhydramine hydrochloride 0.3 Methylparaben 0.2 (D) Purified water 37.75 (E) Perfume 0.1

(Production method) (A) was dissolved in (B) and (D) and (E) in which (C) was dissolved were added thereto to prepare a hair tonic.

Example 5. Hair treatment (A) Liquid paraffin 2.0 Methylpolysiloxane (10cs) 2.0 Cetanol 4.0 Plantain extract (Production Example 5) 4.5 (B) Stearyltrimethylammonium chloride 3.0 Distearyldimethylammonium chloride 0.5 Propylene glycol 5.0 Piroctone olamine 0.25 Purified water 40.0 (C) Hydrolyzed collagen 0.5 Hyaluronic acid 0.01 Bovine placenta extract 0.5 Purified water 40.09 Diphenhydramine hydrochloride 0.25 Methylparaben 0.2 (D) Perfume 0.1

(Manufacturing method) (A) and (B) each at 80 ° C.
And emulsify by mixing them. Thereafter, the mixture was cooled to around 40 ° C., at which point (C) was added, and further (D) was added to prepare a hair treatment.

Example 6. Hair shampoo (A) lauryl sulphate triethanolamine 10.0 Sodium lauryl sulphate 5.0 Coconut oil diethanolamide 2.0 Propylene glycol 5.0 Piroctone olamine 0.25 Benzyl nicotinate 0.1 psyllium extract (Production Example 3) 1.0 (B) Trichlorocarbanilide 0.25 Purification Water 76.3 (C) Perfume 0.1

(Production method) (A) was mixed at 80 ° C., then cooled to about 40 ° C., (B) was added, and (C) was further added to prepare a hair shampoo.

Example 7. Hair rinse (A) Liquid paraffin 0.5 Methyl polysiloxane (10 cs) 0.5 Cetanol 2.0 Stearyl trimethyl ammonium chloride 3.0 Psyllium extract (Production example 2) 2.0 (B) 1,3-Butylene glycol 5.0 Purified water 40.0 Diphenhydramine hydrochloride 0.25 (C) Glycyrrhizin Dipotassium 0.25 Purified water 46.4 (D) Perfume 0.1

(Manufacturing method) (A) and (B) are each at 80 ° C.
And emulsify by mixing at that point. Then 40 ° C
After cooling to near, (C) was added, and (D) was further added to prepare a hair rinse.

Example 8. Hair Cream (A) Psyllium Extract (Production Example 1) 2.5 Vaseline 7.0 Beeswax 8.0 Liquid Paraffin 37.0 Polyoxyethylene (20E.O.) Cetyl Ether 3.0 Glyceryl Monostearate 2.0 Vitamin E Nicotinate 0.1 (B) Purified Water 32.1 Propylene Glycol 5.0 Diphenhydramine hydrochloride 0.2 Glycyrrhizin dipotassium 0.2 Ethylparaben 0.3 (C) Perfume 0.1

(Production Method) (A) was mixed and dissolved at 80 ° C., and then (B) which had been heated to 80 ° C. was gradually added to (A) to form a cream. Thereafter, the mixture was cooled to 40 ° C., and (C) was added to prepare a hair cream.

The hair growth and hair growth agents of the present invention obtained in Examples 4 to 8 were tested for hair growth and hair growth effects in the same manner as in Examples 1 to 3 or in a similar manner. In addition, no skin disorders such as deterioration of scalp condition and inflammatory reaction were observed.

[0042]

EFFECTS OF THE INVENTION According to the present invention, it is possible to provide a hair-growth / hair-growth material which has an excellent hair growth / hair-growth effect and which is excellent in safety without causing skin damage due to long-term continuous use.

Claims (3)

[Claims] 1. A hair-growth / hair-growth material comprising an extract obtained by extracting from psyllium with a water-soluble organic solvent or a water-containing water-soluble organic solvent. 2. The content of the extract is 0.001-10.
The hair-growth / hair-growth material according to claim 1, which is in weight%. 3. The hair-growth according to claim 1, wherein the hair-growth / hair-growth material contains a skin peripheral vasodilator.
Hair restoration.