JPH1045542A - Trichogen - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a trichogen containing the extract of Sesbania grandiflora, excellent in the trichogenous effect and good in safety. SOLUTION: This trichogen contains the extract of Sesbania grandiflora, an alias; Agasti in the family Leguminosae and distributed in tropical and mild districts in an amount of 0.001-10wt.%, preferably 0.05-5wt.%. The addition of a skin peripheral vasodilator (e.g. carpronium chloride, vitamin E) exhibits a more preferable trichogenous effect. The extract is obtained by extracting the dried or ground product of the Sesbania grandiflora plant bodies with a water-soluble organic solvent or with a water-containing water-soluble organic solvent (e.g. ethanol, acetone). A skin trouble, etc., caused by the employment of the trichogen for a long period is not recognized, and the safety of the trichogen is thereby excellent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD [0001] The present invention relates to a novel hair growth / hair restoration material, and more particularly, to an excellent hair growth / hair restoration effect,
In addition, it is intended to provide a hair-growth / hair-growth material which is sufficiently safe to withstand long-term use. [0002]

2. Description of the Related Art Various herbal medicine extracts or various compounds have been blended with hair growth and hair-growth agents that have been provided so far. For example, as herbal extracts, extracts such as Yokuinin, Kashi, etc. (see Japanese Patent Publication No. 1-14511, JP-A No. 2-48514, etc.), and compounds include vitamin E, alloxazine, pyridine N-oxide, adenosine-3. ', 5'-cyclic monophosphate, etc. (JP-A-64-56608, JP-A-
1-261321, JP-A-2-204406, etc.).

[0003]

However, the hair-growth / hair-growth agents provided so far are as follows.
Various herbal extracts and various compounds have been applied, but few have a remarkable effect, and those having a certain effect have strong irritation to cause dermatitis,
There are drawbacks such as difficulty in continuous use.

[0004] The present invention has been made in view of such circumstances, and provides a hair growth and fostering material that is excellent in hair growth and fostering effects and has sufficient safety to withstand long-term use. That is the task.

[0005]

Means for Solving the Problems The inventors of the present invention have conducted extensive studies to solve the above problems, and as a result, an extract obtained from a specific plant belonging to the legume family has an excellent hair growth / hair-growth effect. And found that there was no safety problem during use, and based on such findings, the present invention was completed.

That is, the present invention relates to a method for extracting an extract obtained by extracting a butterfly, preferably a water-soluble organic solvent or a water-containing water-soluble organic solvent, from 0.001 to 10%.
The present invention relates to a hair-growth / hair-growth material which is contained in the range of weight%.

[0007] The present invention also relates to a hair growth and fostering material further comprising a skin peripheral vasodilator in the above hair growth and fostering material.

The present invention will be described in detail below. First of all, a Japanese butterfly (scientific name: Sesbania grand) applied to the present invention
Iflora, also known as Agasti, is a herbaceous shrub belonging to the legume genus Tsunoxanem distributed in tropical and warm regions of the world. Hitherto, the pod has been used as a tonic and the leaf juice has been used as a headache, but it has never been applied as a hair agent, nor has it been tested for its hair growth and hair growth effects. It was not found at all and was found for the first time by the present inventors.

Next, in order to obtain the extract according to the present invention from the above-mentioned rosette butterfly, a plant obtained by drying or pulverizing the plant as it is is extracted with a monohydric alcohol such as methanol, ethanol, propanol or butanol,
Polyhydric alcohols such as 1,3-butylene glycol and propylene glycol, or water-soluble organic solvents such as acetone, tetrahydrofuran and dioxane, or the above monohydric alcohols, polyhydric alcohols or acetone, tetrahydrofuran and dioxane are preferably 50% by weight or more. Containing water-soluble water-soluble organic solvent, further hexane, heptane,
Extraction is performed using a water-insoluble organic solvent such as cyclohexane and ethyl acetate, but it is preferable to use a water-soluble organic solvent or a water-containing water-soluble organic solvent.

[0010] As a specific method, the Shirogoh butterfly 10
0 g is subjected to digestion extraction with 0.5 to 5 liters of extraction solvent at room temperature to the boiling point of the extraction solvent at room temperature for 7 to 10 days and at heating for 4 to 8 hours once or twice. Combine these extracts,
After suction filtration, the mixture is concentrated under reduced pressure to remove the solvent to obtain a viscous or dry extract. The obtained extract is dissolved or dispersed and diluted with an appropriate solvent or the like as it is, and then mixed with a base to obtain the hair growth and hair growth material of the present invention.

Here, the content of the extract of the piercing butterfly, which is contained as an active ingredient of the hair growth / hair restoration according to the present invention, is preferably 0.001 to 10% by weight, particularly preferably 0.05 to 5% by weight. is there. Content is 0.001% by weight
If the amount is less than 10%, the hair growth effect is reduced, and if the amount exceeds 10% by weight, the stability is reduced.

Next, the hair-growth / hair-growth material of the present invention has a more preferable hair-growth / hair-growth effect when it contains a skin peripheral vasodilator in addition to the above-mentioned extract of white grouse. Examples of such skin peripheral vasodilators include carpronium chloride, benzyl nicotinate, vitamin E,
Examples thereof include vitamin E acetate, vitamin E linoleate, vitamin E nicotinate, capsicum tincture, and one or more of these are used.

[0013] The hair growth and fostering composition of the present invention includes, in addition to the extract of the radish butterfly described above and the skin peripheral vasodilator, additives usually used for hair growth and fostering, such as hinokitiol, cationic surfactants and parabens. Bactericides such as 1-Menthol, cooling agents, hydrocarbons, waxes, fats and oils,
Oils such as esters, higher fatty acids, higher alcohols and the like, other surfactants, fragrances, pigments, antioxidants, ultraviolet protection agents, alcohols, pH adjusters, water and the like can be blended.

The hair growth and hair-growth agent of the present invention includes various dosage forms such as hair tonic, shampoo, conditioner, pomade, hair lotion, hair cream, hair treatment and the like, and they are prepared by a conventional method.

[0015]

BEST MODE FOR CARRYING OUT THE INVENTION Here, a production example of the extract of white-breasted butterfly according to the present invention will be shown. Production Example 1. 70% of 100 g of dried whole grass of butterflies
It was immersed and extracted with 1 l of ethanol at room temperature for 10 days, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 3.4%)

Manufacturing Example 2. Dried whole grass of butterflies 10
0 g is immersed in 1 L of ethanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extracted extract. (Yield 3.7%)

Manufacturing Example 3. Dried whole grass of butterflies 10
0 g is immersed in 1 liter of acetone, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extracted extract. (Yield 2.6%)

Production Example 4. White-breasted dried grass 10
0 g is immersed in 1 l of butanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extracted extract. (Yield 2.7%)

Production Example 5. White-breasted dried grass 10
0 g is immersed in 1 liter of an extraction solvent of propylene glycol: distilled water = 1: 1, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper,
The filtrate was evaporated to dryness to obtain an extract. (Yield 2.0%)

Production Example 6. White-breasted dried grass 10
0 g was immersed in 1 L of ethyl acetate for 10 days at room temperature for extraction.
The residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 1.9%)

Next, a test was conducted on the effect of the extract of the piercing butterfly, obtained as described above, on hair growth in mice.

"Mouse Hair Growth Evaluation Test" (1) Sample The present invention product: 70% ethanol aqueous dispersion containing 5% of extract of Shirogyo butterfly (Production Example 2) Comparative product: 70% ethanol containing 1% of vitamin E Aqueous dispersion control: 70% ethanol aqueous solution

(2) Test method Using 9-week-old C3H mice, one group consisted of 10 mice, and three groups were formed. The backs of these groups were shaved to a size of 2.0 × 2.0 cm and then removed the next day. After applying 0.04g of each sample to the hair part,
On day 16, the density of hair growth at the site was evaluated as the degree of increase in blackness using a color difference meter. Table 1 shows the results.

[0024]

[Table 1]

As is clear from the results shown in Table 1, it is found that in the extract of white rosier butterfly according to the present invention, the L value is decreased and the blackness is increased as compared with the control. On the other hand, in the vitamin E of the comparative product, the L value was hardly decreased as compared with the control. This is presumed to be the result that the extract of the piercing butterfly according to the present invention stimulated the hair root, increased blood circulation around the hair follicle, and activated metabolism.

[0026]

The present invention will be further described with reference to the following examples.
In addition, the compounding amount is a weight part. Examples 1-3. Hair Tonic Using the ingredients and blending composition shown in Table 2 below, each ingredient was dissolved by heating and solubilized to prepare a hair tonic.

[0027]

[Table 2]

"Human hair growth / hair growth evaluation test" (1) Sample The present invention product: Hair tonic of Examples 1 to 3 Comparative product: The extract of Shirogyo butterfly (Production Example 2) was removed from the hair tonic of Example 1 ( Increase the amount of water) Hair tonic

(2) Test Method Twenty panelists who complain of thinning hair and alopecia were divided into four groups of five people each, and a long-term continuous test for 6 months was carried out using each sample. As an application method, a method of evenly applying to the head twice a day was used as in the case of using a normal tonic. The evaluation was performed at the third and sixth months after the start of use, and the number of subjects who felt that the amount of downy hair and hard hair had increased was measured. In addition, at the end of the test, they were asked to improve their scalp condition and reduce dandruff. Table 3 shows the results.

[0030]

[Table 3]

As is clear from the results shown in Table 3, the hair-growth / hair-growth agent of the present invention has a hair-growth effect since the number of people who have bristles and bristles is increasing. Was given. At the end of the test, the number of persons who reported improvement in scalp condition and reduction of dandruff generation in Example 1 was 4 and in Example 2 was 3. From this, the hair growth / hair growth material of the present invention was also confirmed to have a hair growth effect. Further, it was confirmed that the safety was high because no skin damage such as deterioration of the scalp condition or inflammatory reaction was observed in any panel during the use test period.

Embodiment 4 Hair tonic (A) Extract of Shirogyo butterfly (Production Example 4) 3.0 Menthol 0.2 Vitamin E 0.05 Carpronium chloride 0.1 (B) Ethanol 50.0 (C) Propylene glycol 5.0 Vitamin B2 0.5 Yeast extract (containing nucleic acid) 0.5 Glycyrrhizin dipotassium 0.3 Diphenhydramine hydrochloride 0.3 Methylparaben 0.2 (D) Purified water 39.75 (E) Fragrance 0.1

(Preparation method) (A) is dissolved in (B),
To this was added (D) and (E) in which (C) was dissolved to prepare a hair tonic.

Example 5. Hair treatment (A) Liquid paraffin 2.0 Methyl polysiloxane (10 cs) 2.0 Cetanol 4.0 Extract of sycamore butterfly (Production Example 5) 4.5 (B) Stearyltrimethylammonium chloride 3.0 Distearyldimethylammonium chloride 0.5 Propylene glycol 5.0 Pyroctone olamine 0.25 Purified water 40.0 (C) Hydrolyzed collagen 0.5 Hyaluronic acid 0.01 Bovine placenta extract 0.5 Purified water 37.19 Diphenhydramine hydrochloride 0.25 Methyl paraben 0.2 (D) Fragrance 0.1

(Manufacturing method) (A) and (B) are each 8
Heat to 0 ° C., mix both and emulsify. Then 40 ° C
After cooling to the vicinity, (C) was added at that point, and (D) was further added to prepare a hair treatment.

Embodiment 6 Hair shampoo (A) lauryl sulfate triethanolamine 10.0 Sodium lauryl sulfate 5.0 Coconut oil diethanolamide 2.0 Propylene glycol 5.0 Piroctone olamine 0.25 Benzyl nicotinate 0.1 White roe butterfly extract (Production Example 3) 1.0 (B) Trichlorocarbanilide 0.25 Purification Water 76.3 (C) Perfume 0.1

(Production method) (A) is mixed at 80 ° C., then cooled to about 40 ° C., (B) is added, and (C) is further added.
Was added to prepare a hair shampoo.

Embodiment 7 Hair rinse (A) Liquid paraffin 0.5 Methyl polysiloxane (10 cs) 0.5 Cetanol 2.0 Stearyl trimethyl ammonium chloride 3.0 White grouse extract (Production Example 2) 2.0 (B) 1,3-Butylene glycol 5.0 Purified water 40.0 Diphenhydramine hydrochloride 0.25 (C) Glycyrrhizin Dipotassium 0.25 Purified water 46.4 (D) Fragrance 0.1

(Production method) 80 (A) and (B)
Warm to ° C., at which point mix and emulsify. Then 4
After cooling to about 0 ° C., (C) was added, and (D) was further added to prepare a hair rinse.

Embodiment 8 FIG. Hair cream (A) White rosy butterfly extract (Production example 1) 2.5 Vaseline 7.0 Beeswax 8.0 Liquid paraffin 37.0 Polyoxyethylene (20E.O.) Cetyl ether 3.0 Glyceryl monostearate 2.0 Vitamin E nicotinate 0.1 (B) Purified water 34.6 Propylene glycol 5.0 Diphenhydramine hydrochloride 0.2 Glycyrrhizin dipotassium 0.2 Ethyl paraben 0.3 (C) Fragrance 0.1

(Preparation method) (A) was mixed and dissolved at 80 ° C.
Next, (B) previously heated to 80 ° C. was gradually added to (A) to form a cream. Then cool down to 40 ° C,
(C) was added to prepare a hair cream.

Example 9. Hair tonic (A) Shirogyo butterfly extract (Production Example 6) 0.5 Salicylic acid 0.3 Menthol 0.2 Pepper tincture 0.01 (B) Ethanol 60.0 (C) Glycerin 5.0 (D) Purified water 33.89 (E) Fragrance 0.1

(Production method) (A) is dissolved in (B),
To this was added (D) and (E) in which (C) was dissolved to prepare a hair tonic.

The hair growth and hair growth effects of the present invention obtained in the above Examples 4 to 9 were tested for hair growth and hair growth effects by the same method as in Examples 1 to 3, and all were excellent. In addition, no skin disorders such as deterioration of scalp condition and inflammatory reaction were observed.

[0045]

EFFECTS OF THE INVENTION According to the present invention, it is possible to provide a hair-growth / hair-growth material which has an excellent hair-growth / hair-growth effect and which is excellent in safety without showing skin disorders due to long-term continuous use.

Claims (4)

[Claims] 1. A hair growth and fostering agent comprising an extract of a piercing butterfly. 2. The hair growth and fostering composition according to claim 1, wherein the extract is extracted with a water-soluble organic solvent or a water-containing water-soluble organic solvent. 3. The content of the extract is 0.001-10.
The hair-growth / hair-growth material according to claim 1, which is in weight%. 4. The hair growth / hair growth material according to claim 1, wherein the hair growth / hair growth material contains a skin peripheral vasodilator.