JPH1045540A - Trichogen - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a trichogen containing the extract of Piper betle L., excellent in the trichogenous effect and good in safety. SOLUTION: This trichogen contains the extract of Piper betle L., a plant originated in Malaysia district in an amount of 0.001-10wt.%, preferably 0.05-5wt.%. The extract is obtained by extracting the dried or ground product of the Piper betle L. plant bodies with a water-soluble organic solvent such as a monohydric alcohol, a polyhydric alcohol, acetone or THF or with a water- containing water-soluble organic solvent containing the water-soluble solvent preferably in a concentration of >=50wt.% for 7-10 days at room temperature or for 4-8hr at a higher temperature and subsequently subjecting the extract to a suction filtration treatment and a vacuum concentration treatment. The addition of a skin peripheral vasodilator (e.g. vitamin E) exhibits a more preferable trichogenous effect. A skin trouble, etc., caused by the employment of the trichogen for a long period is not recognized, and the safety of the trichogen is thereby excellent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel hair growth / hair restoration material, and more particularly, to provide a hair growth / hair restoration material having excellent hair growth / hair growth effects and having sufficient safety to withstand long-term use. Is what you do.

[0002]

2. Description of the Related Art Conventionally provided hair growth and hair growth products contain various crude drug extracts or various compounds. For example, crude drug extracts include extracts such as yoquinin and cashew (see Japanese Patent Publication No. 1-13451, JP-A-2-48514, etc.), and compounds such as vitamin E, alloxazine, pyridine N-oxide and adenosine-3. ', 5'-cyclic monophosphate (JP-A-64-56608,
1-261321, JP-A-2-204406, etc.).

[0003]

However, the hair growth and hair growth materials provided so far include, as mentioned in the above examples,
Various crude drug extracts and various compounds have been applied, but few have a remarkable effect, and those having a certain effect are so stimulating that dermatitis is caused,
There are drawbacks such as difficulty in continuous use.

[0004] The present invention has been made in view of such circumstances, and provides a hair growth and fostering material that is excellent in hair growth and fostering effects and has sufficient safety to withstand long-term use. That is the task.

[0005]

Means for Solving the Problems The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, it has been found that an extract obtained from a specific plant belonging to the family Pepperaceae has excellent hair growth and hair growth effects. And found that there was no safety problem during use, and based on such findings, the present invention was completed.

[0006] That is, the present invention relates to a method for extracting an extract obtained by extracting betel (konsho) with a water-soluble organic solvent or a water-containing water-soluble organic solvent, preferably from 0.001 to 10
The present invention relates to a hair growth and fostering agent characterized in that it is contained in the range of weight%.

[0007] The present invention also relates to a hair growth and fostering material further comprising a skin peripheral vasodilator in the above hair growth and fostering material.

Hereinafter, the present invention will be described in detail. First, betel (scientific name: Piper betle L.) applied to the present invention is an evergreen climbing plant belonging to the genus Pepper in the Peaceae family native to the Malaysian region. Until now, betel has been medicated for coughing leaves and stems, causing stomach ache, skin diseases, sperm of spikelets,
It has been known to use it for toothache and to use piveric acid or the like as a component thereof for external preparation for skin (Japanese Patent Application Laid-Open No. 6-336417), but it has not been applied as a hair material, and No examples have been found for the hair-growth effect at all, and were found for the first time by the present inventors.

Next, in order to obtain the extract of the present invention from the above betel, the plant is dried or ground as it is, and the plant is extracted with an extraction solvent such as methanol, ethanol or the like.
Monohydric alcohols such as propanol and butanol, 1,3
-Polyhydric alcohols such as butylene glycol and propylene glycol, or water-soluble organic solvents such as acetone, tetrahydrofuran and dioxane, or the above monohydric alcohols, polyhydric alcohols or acetone, tetrahydrofuran and dioxane are preferably contained in an amount of 50% by weight or more. Extraction is carried out using a water-containing water-soluble organic solvent, and further using a water-insoluble organic solvent such as hexane, heptane, cyclohexane, and ethyl acetate. Preferably, a water-soluble organic solvent or a water-containing water-soluble organic solvent is used.

As a specific method, 100 g of betel is used in an extraction solvent of 0.5 to 5 liters at a temperature ranging from room temperature to the boiling point of the extraction solvent, at room temperature for 7 to 10 days, at heating for 4 to 8 hours, and at 1 to 8 hours.
Extract by digestion twice. These extracts are combined, filtered with suction, and then concentrated under reduced pressure to remove the solvent to obtain a viscous or dried extract. The obtained extract is dissolved or dispersed and diluted with an appropriate solvent or the like as it is, and then mixed with a base to obtain the hair growth and hair growth material of the present invention.

Here, the content of the betel extract contained as an active ingredient of the hair growth / hair restoration according to the present invention is preferably 0.001 to 10% by weight, particularly preferably 0.05%.
~ 5% by weight. When the content is less than 0.001% by weight, the hair growth effect is reduced, and when the content exceeds 10% by weight, the stability is reduced.

Next, the hair growth and hair growth agent of the present invention has a more preferable hair growth and hair growth effect when it contains a skin peripheral vasodilator in addition to the above betel extract. Such skin peripheral vasodilators include, for example, carpronium chloride, benzyl nicotinate, vitamin E, vitamin E acetate, vitamin E linoleate, vitamin E nicotinate, pepper tincture, etc., and one or more of these. Is used.

The hair growth and fostering composition of the present invention includes the betel extract and the skin peripheral vasodilator as well as additives usually used for hair growth and fostering, such as hinokitiol.
Cationic surfactants, disinfectants such as parabens, cooling agents such as l-menthol, hydrocarbons, waxes, oils and fats, esters, higher fatty acids, oils such as higher alcohols, other surfactants, fragrances, dyes, Antioxidants, UV protection agents, alcohols, pH adjusters, water and the like can be added.

The hair growth and hair growth agent of the present invention includes various dosage forms, for example, hair tonic, shampoo, rinse, pomade, hair lotion, hair cream, hair treatment and the like, and is prepared according to a conventional method.

[0015]

BEST MODE FOR CARRYING OUT THE INVENTION A production example of a betel extract according to the present invention will now be described. Production Example 1. 100 g of dried whole betel plant was immersed and extracted with 1 liter of 70% ethanol at room temperature for 10 days, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 3.2%)

Production Example 2 100 g of dried whole betel plant is immersed in 1 liter of ethanol and transferred to a Soxhlet extractor.
Perform warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (3.6% yield)

Production Example 3 100 g of whole dried betel plant is immersed in 1 liter of acetone, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 3.3%)

Production Example 4 100 g of dried whole betel plant is immersed in 1 liter of butanol, transferred to a Soxhlet extractor,
Perform warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 3.1%)

Production Example 5 100 g of dried betel whole plant is mixed with 1 l of an extraction solvent of propylene glycol: distilled water = 1: 1
, Transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.3%)

Production Example 6 100 g of dried whole betel plant was immersed and extracted with 1 l of ethyl acetate at room temperature for 10 days, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (1.9% yield)

Next, a test was conducted on the effect of the betel extract obtained as described above on hair growth in mice.

"Mouse Hair Growth Evaluation Test" (1) Sample The present invention: 70% ethanol aqueous dispersion containing 5% betel extract (Production Example 2) Comparative: 70% 1% vitamin E % Ethanol aqueous dispersion Control: 70% ethanol aqueous solution

(2) Test method Using 9-week-old C3H mice, one group consisted of 10 mice, and three groups were formed. The backs of these groups were shaved to a size of 2.0 × 2.0 cm and then removed the next day. After applying 0.04 g of each sample to the hair site,
On the 16th day, the density of hair growth at the site was evaluated as a degree of black increase using a color difference meter. Table 1 shows the results.

[0024]

[Table 1]

As is clear from the results shown in Table 1, the betel extract according to the present invention has a lower L value than the control.
It can be seen that the value decreases and the blackness increases. On the other hand, the vitamin E of the comparative product has L
Little decrease in value was observed. This is presumed to be the result that the betel extract according to the present invention stimulated the hair root, increased blood circulation around the hair follicle, and activated metabolism.

[0026]

The present invention will be further described with reference to the following examples.
In addition, the compounding amount is a weight part. Embodiments 1-3. Hair tonic Using the components and composition shown in Table 2 below, each component was heated and dissolved, and solubilized to prepare a hair tonic.

[0027]

[Table 2]

"Human hair growth / hair growth evaluation test" (1) Sample The present invention product: Hair tonic of Examples 1 to 3 Comparative product: The betel extract extract (Production Example 2) was removed from the hair tonic of Example 1. (Increase water) Hair tonic

(2) Test Method Twenty panelists complaining of alopecia and alopecia were divided into four groups of five each, and a long-term continuous test for 6 months was performed using each sample. The application method was a method of evenly applying the composition to the head twice a day as in the usual tonic usage. The evaluation was performed on the third and sixth months after the start of use, and the degree of increase in the number of test subjects who felt that the hairs and hairs had increased was measured. In addition, at the end of the test, they were asked to report their scalp condition and reduce dandruff. Table 3 shows the results.

[0030]

[Table 3]

As is evident from the results in Table 3, the hair growth and growth stimulant of the present invention has a hair growth effect because the number of people who have developed alveoli and those who have hard hair have increased. Was done. At the end of the test, the number of persons who reported improvement in the condition of the scalp and reduced occurrence of dandruff were 4 in Example 1 and 3 in Example 2. From this, the hair growth / hair growth material of the present invention was also confirmed to have a hair growth effect. Furthermore, no skin damage such as deterioration of the scalp condition or inflammatory reaction was observed in any of the panelists during the use test period, confirming that the safety was high.

Embodiment 4 Hair Tonic (A) Betel extract (Production Example 4) 3.0 Menthol 0.2 Vitamin E 0.05 Carpronium chloride 0.1 (B) Ethanol 50.0 (C) Propylene glycol 5.0 Vitamin B2 0.5 Yeast extract (containing nucleic acid) 0.5 Glycyrrhizin dipotassium 0.3 Diphenhydramine hydrochloride 0.3 Methylparaben 0.2 (D) Purified water 39.75 (E) Fragrance 0.1

(Preparation method) (A) was dissolved in (B), and (D) and (E), in which (C) was dissolved, were added thereto to prepare a hair tonic.

Example 5. Hair treatment (A) Liquid paraffin 2.0 Methylpolysiloxane (10cs) 2.0 Cetanol 4.0 Betel extract (Production example 5) 4.5 (B) Stearyltrimethylammonium chloride 3.0 Distearyldimethylammonium chloride 0.5 Propylene glycol 5.0 Piroctone olamine 0.25 Purified water 40.0 (C) Hydrolyzed collagen 0.5 Hyaluronic acid 0.01 Bovine placenta extract 0.5 Purified water 37.19 Diphenhydramine hydrochloride 0.25 Methylparaben 0.2 (D) Perfume 0.1

(Preparation method) (A) and (B) were each heated to 80 ° C.
And emulsify by mixing them. Thereafter, the mixture was cooled to around 40 ° C., at which point (C) was added, and further (D) was added to prepare a hair treatment.

Embodiment 6 Hair shampoo (A) lauryl sulfate triethanolamine 10.0 sodium lauryl sulfate 5.0 coconut oil diethanolamide 2.0 propylene glycol 5.0 piroctone olamine 0.25 benzyl nicotinate 0.1 betel extract (Production Example 3) 1.0 (B) trichlorocarbanilide 0.25 purification Water 76.3 (C) Fragrance 0.1

(Preparation method) (A) was mixed at 80 ° C., then cooled to about 40 ° C., (B) was added, and (C) was further added to prepare a hair shampoo.

Embodiment 7 Hair rinse (A) Liquid paraffin 0.5 Methyl polysiloxane (10 cs) 0.5 Cetanol 2.0 Stearyl trimethyl ammonium chloride 3.0 Betel extract (Production example 2) 2.0 (B) 1,3-Butylene glycol 5.0 Purified water 40.0 Diphenhydramine hydrochloride 0.25 (C) Glycyrrhizin Dipotassium 0.25 Purified water 46.4 (D) Perfume 0.1

(Preparation method) (A) and (B) were each heated to 80 ° C.
And emulsify by mixing at that point. Then 40 ° C
After cooling to near, (C) was added, and (D) was further added to prepare a hair rinse.

Embodiment 8 FIG. Hair cream (A) Betel extract (Preparation example 1) 2.5 Vaseline 7.0 Beeswax 8.0 Liquid paraffin 37.0 Polyoxyethylene (20E.O.) cetyl ether 3.0 Glyceryl monostearate 2.0 Vitamin E nicotinate 0.1 (B) Purified water 34.6 Propylene glycol 5.0 Diphenhydramine hydrochloride 0.2 Glycyrrhizin dipotassium 0.2 Ethylparaben 0.3 (C) Perfume 0.1

(Preparation method) (A) was mixed and dissolved at 80 ° C., and then (B), which had been heated to 80 ° C. in advance, was gradually added to (A) to form a cream. Thereafter, the mixture was cooled to 40 ° C., and (C) was added to prepare a hair cream.

Example 9. Hair tonic (A) Betel extract (Preparation Example 6) 0.5 Salicylic acid 0.3 Menthol 0.2 Pepper tincture 0.01 (B) Ethanol 60.0 (C) Glycerin 5.0 (D) Purified water 33.89 (E) Fragrance 0.1

(Preparation method) (A) was dissolved in (B), and (D) and (E), in which (C) was dissolved, were added thereto to prepare a hair tonic.

The hair growth and hair growth effects of the present invention obtained in the above Examples 4 to 9 were tested for hair growth and hair growth effects by the same method as in Examples 1 to 3 or according to the same method. No skin damage such as deterioration of the scalp condition and inflammatory reaction was observed at all.

[0045]

According to the present invention, it is possible to provide a hair-growth / hair-growing agent which has an excellent hair-growth / hair-growth effect and which is free from skin disorders due to long-term continuous use and which is excellent in safety.

Claims (4)

[Claims] 1. A hair-growth / hair-growing agent comprising betel extract. 2. The hair growth and fostering composition according to claim 1, wherein the extract is extracted with a water-soluble organic solvent or a water-containing water-soluble organic solvent. 3. The content of the extract is from 0.001 to 10
3% by weight.
Hair restoration. 4. The hair growth and fostering composition according to claim 1, wherein the hair growth and fostering composition contains a skin peripheral vasodilator.