JPH09241133A - Hair-growing agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a new safe hair-growing agent excellent in the hair-growing effect and capable of being sufficiently used over a long period by using an extract obtained from a specific plant belonging to the family Leguminosae. SOLUTION: This hair-growing agent contains an extract obtained by extracting Bauhinia variegata, a small tree belonging to the genus Bauhinia in the family Leguminosae, originated in the Southeast Asia with a water-soluble organic solvent or a water-containing organic solvent. The content of the extract is preferably 0.001-10wt.%, especially 0.05-5wt.%. When the hair-growing agent contains a skin peripheral vasodilator in addition to the extract of the Bauhinia variegata, the hair-growing agent exhibits a more preferable hair-growing effect. The skin peripheral vasodilator includes carpronium chloride, benzyl nicotinate, vitamin E, and vitamin E acetate. The hair-growing agent can be prepared in the forms such as hair tonic, shampoo, hair rinse, pomade, hair lotion and hair cream.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel hair growth / hair restoration material, and more particularly, to provide a hair growth / hair restoration material having excellent hair growth / hair growth effects and having sufficient safety to withstand long-term use. Is what you do.

[0002]

2. Description of the Related Art Conventionally provided hair growth and hair growth products contain various crude drug extracts or various compounds. For example, crude drug extracts include extracts such as yoquinin and cashew (see Japanese Patent Publication No. 1-13451, JP-A-2-48514, etc.), and compounds such as vitamin E, alloxazine, pyridine N-oxide and adenosine-3. ', 5'-cyclic monophosphate (JP-A-64-56608,
1-261321, JP-A-2-204406, etc.).

[0003]

However, the hair growth and hair growth materials provided so far include, as mentioned in the above examples,
Various crude drug extracts and various compounds have been applied, but few have a remarkable effect, and those having a certain effect are so stimulating that dermatitis is caused,
It has drawbacks such as difficulty in continuous use.

[0004] The present invention has been made in view of such circumstances, and provides a hair growth and fostering material that is excellent in hair growth and fostering effects and has sufficient safety to withstand long-term use. That is the task.

[0005]

Means for Solving the Problems As a result of intensive studies to solve the above problems, the present inventor has found that an extract obtained from a particular plant belonging to the legume family has an excellent hair growth / hair growth effect. The present invention has been found to have no safety problem during use, and the present invention has been completed based on such findings.

That is, according to the present invention, an extract obtained by extracting from Firithosinka with a water-soluble organic solvent or a water-containing water-soluble organic solvent is preferably 0.001 to 1
The present invention relates to a hair-growth / hair-growth material which is contained in an amount of 0% by weight.

[0007] The present invention also relates to a hair growth and fostering material further comprising a skin peripheral vasodilator in the above hair growth and fostering material.

Hereinafter, the present invention will be described in detail. First, the firiso cinca (scientific name: Bauhinia vari) applied to the present invention.
egata) is a small Takagi tree belonging to the genus Scutellaria, which is native to Southeast Asia. Up to now, it was known that flowers were used for medicinal purposes for hepatitis, pneumonia, etc., but it had never been practically applied from the external point of view, and an example was also verified for hair growth and hair growth effects. Was not found at all, and was first discovered by the present inventor.

Next, in order to obtain the extracted extract according to the present invention from the above-mentioned filisocinca, the plant is dried or ground as it is, and the extraction solvent such as monohydric alcohol such as methanol, ethanol, propanol, butanol, 1, Containing preferably 50% by weight or more of polyhydric alcohol such as 3-butylene glycol and propylene glycol, water-soluble organic solvent such as acetone, tetrahydrofuran and dioxane, or the above monohydric alcohol, polyhydric alcohol or acetone, tetrahydrofuran and dioxane. The extraction is carried out using a water-containing water-soluble organic solvent as described above, and a non-water-soluble organic solvent such as hexane, heptane, cyclohexane, ethyl acetate, etc., but preferably a water-soluble organic solvent or a water-containing water-soluble organic solvent is used.

As a concrete method, filisocinka 1
00g is digested and extracted with 0.5 to 5 liters of extraction solvent at room temperature to the boiling point of the extraction solvent at room temperature for 7 to 10 days and at heating for 4 to 8 hours once or twice. Combine these extracts,
After suction filtration, the mixture is concentrated under reduced pressure to remove the solvent to obtain a viscous or dry extract. The obtained extract is dissolved or dispersed and diluted with an appropriate solvent or the like as it is, and then mixed with a base to obtain the hair growth and hair growth material of the present invention.

The content of the filisocinca extract extracted as an active ingredient of the hair-growth and hair-growth agent according to the present invention is preferably 0.001 to 10% by weight, particularly preferably 0.05 to 5% by weight. . Content is 0.001% by weight
If it is less than 10% by weight, the hair-growth effect is lowered, and if it exceeds 10% by weight, the stability is lowered.

Next, the hair growth and hair growth product of the present invention has a more preferable hair growth and hair growth effect when it contains a skin peripheral vasodilator in addition to the above-mentioned filisocinca extract. Such skin peripheral vasodilators include, for example, carpronium chloride, benzyl nicotinate, vitamin E, vitamin E acetate, vitamin E linoleate, vitamin E nicotinate, pepper tincture, etc., and one or more of these. Is used.

In addition to the above-mentioned filisocinca extract and skin peripheral vasodilator, the hair-growing / hair-growing agents of the present invention include additives commonly used in hair-growing / hair-growing agents, such as hinokitiol, cationic surfactants, and parabens. Disinfectant, etc.
-Refrigerants such as menthol, hydrocarbons, waxes, oils and fats, esters, higher fatty acids, oils such as higher alcohols, other surfactants, fragrances, pigments, antioxidants, UV protectors, alcohols, pH A regulator, water and the like can be added.

The hair growth and hair growth agent of the present invention includes various dosage forms, for example, hair tonic, shampoo, rinse, pomade, hair lotion, hair cream, hair treatment and the like, and is prepared according to a conventional method.

[0015]

BEST MODE FOR CARRYING OUT THE INVENTION Here, a production example of the filisocinca extract according to the present invention will be shown. Production Example 1. 70 g of dried whole grass of finisoshinka
% L of 1% ethanol at room temperature for 10 days, extract the residue with filter paper, evaporate the filtrate to dryness,
An extract was obtained. (Yield 3.1%)

Production Example 2 Dried filthy shinka 1
00g is immersed in 1 liter of ethanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, the filtrate was evaporated to dryness,
An extract was obtained. (Yield 3.9%)

Production Example 3 Dried filthy shinka 1
00g is immersed in 1 liter of acetone, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.8%)

Production Example 4 Dried filthy shinka 1
00g is immersed in 1 liter of butanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, the filtrate was evaporated to dryness,
An extract was obtained. (Yield 2.5%)

Production Example 5 Dried filthy shinka 1
00 g is immersed in 1 liter of an extraction solvent of propylene glycol: distilled water = 1: 1, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.0%)

Production Example 6 Dried filthy shinka 1
00 g was immersed and extracted with 1 L of ethyl acetate at room temperature for 10 days, the residue was filtered off with a filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 1.8%)

Next, a test was carried out for the effect of the extract of Phyllis cinca thus obtained on the hair growth of mice.

"Mouse Hair Growth Evaluation Test" (1) Sample This product: Firiso cinca extract (Production Example 2)
70% ethanol water dispersion containing 5% of water Comparative product: 70% ethanol water dispersion containing 1% of vitamin E Control: 70% ethanol aqueous solution

(2) Test method Using 9-week-old C3H mice, one group consisted of 10 mice, and three groups were formed. The backs of these groups were shaved to a size of 2.0 × 2.0 cm and then removed the next day. After applying 0.04 g of each sample to the hair site,
On the 16th day, the density of hair growth at the site was evaluated as a degree of black increase using a color difference meter. Table 1 shows the results.

[0024]

[Table 1]

As is clear from the results shown in Table 1, in the filisocinca extract according to the present invention, the L value is decreased and the blackness is increased as compared with the control. On the other hand, the vitamin E of the comparative product showed almost no decrease in the L value as compared with the control. This is presumed to be the result of the extract of Frysocinca vulgaris according to the present invention stimulating hair roots, making blood circulation around hair follicles more active, and activating metabolism.

[0026]

The present invention will be further described with reference to the following examples.
In addition, the compounding amount is a weight part. Embodiments 1-3. Hair tonic Using the components and composition shown in Table 2 below, each component was heated and dissolved, and solubilized to prepare a hair tonic.

[0027]

[Table 2]

"Human Hair Growth / Hair Growth Evaluation Test" (1) Sample: Product of the present invention: Hair tonic of Examples 1 to 3 Comparative product: Hair tonic of Example 1 except for the extract of Phyllisosinka (Production Example 2). (Increase water) Hair tonic

(2) Test Method Twenty panelists complaining of alopecia and alopecia were divided into four groups of five each, and a long-term continuous test for 6 months was performed using each sample. The application method was a method of evenly applying the composition to the head twice a day as in the usual tonic usage. The evaluation was performed on the third and sixth months after the start of use, and the degree of increase in the number of test subjects who felt that the hairs and hairs had increased was measured. In addition, at the end of the test, they were asked to report their scalp condition and reduce dandruff. Table 3 shows the results.

[0030]

[Table 3]

As is evident from the results in Table 3, the hair growth and growth stimulant of the present invention has a hair growth effect because the number of people who have developed alveoli and those who have hard hair have increased. Was done. At the end of the test, the condition of the scalp was improved, and the number of persons who declared reduction of the occurrence of dandruff was 3 in Example 1 and 1 in Example 2. From this, the hair growth / hair growth material of the present invention was also confirmed to have a hair growth effect. Furthermore, no skin damage such as deterioration of the scalp condition or inflammatory reaction was observed in any of the panelists during the use test period, confirming that the safety was high.

Example 4. Hair Tonic (A) Filithosinca Extract (Production Example 4) 3.0 Menthol 0.2 Vitamin E 0.05 Carpronium chloride 0.1 (B) Ethanol 50.0 (C) Propylene glycol 5.0 Vitamin B2 0.5 Yeast extract (containing nucleic acid) 0.5 Glycyrrhizin dipotassium 0.3 Diphenhydramine hydrochloride 0.3 Methylparaben 0.2 (D) Purified water 39.75 (E) Perfume 0.1

(Preparation method) (A) was dissolved in (B), and (D) and (E), in which (C) was dissolved, were added thereto to prepare a hair tonic.

Example 5. Hair Treatment (A) Liquid paraffin 2.0 Methylpolysiloxane (10cs) 2.0 Cetanol 4.0 Firisoshinka extract (Production Example 5) 4.5 (B) Stearyltrimethylammonium chloride 3.0 Distearyldimethylammonium chloride 0.5 Propylene glycol 5.0 Piroctone olamine 0.25 Purified water 40.0 (C) Hydrolyzed collagen 0.5 Hyaluronic acid 0.01 Bovine placenta extract 0.5 Purified water 37.19 Diphenhydramine hydrochloride 0.25 Methylparaben 0.2 (D) Perfume 0.1

(Preparation method) (A) and (B) were each heated to 80 ° C.
And emulsify by mixing them. Thereafter, the mixture was cooled to around 40 ° C., at which point (C) was added, and further (D) was added to prepare a hair treatment.

Example 6. Hair shampoo (A) Lauryl sulphate triethanolamine 10.0 Sodium lauryl sulphate 5.0 Coconut oil diethanolamide 2.0 Propylene glycol 5.0 Pyroctone olamine 0.25 Benzyl nicotinate 0.1 Firisocinca extract (Production example 3) 1.0 (B) Trichlorocarbanilide 0.25 Purification Water 76.3 (C) Perfume 0.1

(Preparation method) (A) was mixed at 80 ° C., then cooled to about 40 ° C., (B) was added, and (C) was further added to prepare a hair shampoo.

Example 7. Hair rinse (A) Liquid paraffin 0.5 Methyl polysiloxane (10 cs) 0.5 Cetanol 2.0 Stearyl trimethyl ammonium chloride 3.0 Frysocinca extract (Production example 2) 2.0 (B) 1,3-Butylene glycol 5.0 Purified water 40.0 Diphenhydramine hydrochloride 0.25 (C) Glycyrrhizin Dipotassium 0.25 Purified water 46.4 (D) Perfume 0.1

(Preparation method) (A) and (B) were each heated to 80 ° C.
And emulsify by mixing at that point. Then 40 ° C
After cooling to near, (C) was added, and (D) was further added to prepare a hair rinse.

Example 8. Hair Cream (A) Filithosinca Extract (Production Example 1) 2.5 Vaseline 7.0 Beeswax 8.0 Liquid Paraffin 37.0 Polyoxyethylene (20E.O.) Cetyl Ether 3.0 Glyceryl Monostearate 2.0 Vitamin E Nicotinate 0.1 (B) Purified Water 34.6 Propylene Glycol 5.0 Diphenhydramine hydrochloride 0.2 Glycyrrhizin dipotassium 0.2 Ethylparaben 0.3 (C) Perfume 0.1

(Preparation method) (A) was mixed and dissolved at 80 ° C., and then (B), which had been heated to 80 ° C. in advance, was gradually added to (A) to form a cream. Thereafter, the mixture was cooled to 40 ° C., and (C) was added to prepare a hair cream.

Example 9. Hair Tonic (A) Filithosinca Extract (Production Example 6) 0.5 Salicylic acid 0.3 Menthol 0.2 Capsicum tincture 0.01 (B) Ethanol 60.0 (C) Glycerin 5.0 (D) Purified water 33.89 (E) Perfume 0.1

(Preparation method) (A) was dissolved in (B), and (D) and (E), in which (C) was dissolved, were added thereto to prepare a hair tonic.

The hair growth and hair growth effects of the present invention obtained in the above Examples 4 to 9 were tested for hair growth and hair growth effects by the same method as in Examples 1 to 3 or according to the same method. No skin damage such as deterioration of the scalp condition and inflammatory reaction was observed at all.

[0045]

According to the present invention, it is possible to provide a hair-growth / hair-growing agent which has an excellent hair-growth / hair-growth effect and which is free from skin disorders due to long-term continuous use and which is excellent in safety.

Claims (4)

[Claims] 1. A hair-growth / hair-growth material containing an extract of filisocinca. 2. The hair growth and fostering composition according to claim 1, wherein the extract is extracted with a water-soluble organic solvent or a water-containing water-soluble organic solvent. 3. The content of the extract is from 0.001 to 10
3% by weight.
Hair restoration. 4. The hair growth and fostering composition according to claim 1, wherein the hair growth and fostering composition contains a skin peripheral vasodilator.