JPH11158045A - Trichogen - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a trichogen having an excellent trichogenous effect and having safety capable of sufficiently enduring its employment over a long period. SOLUTION: This trichogen contains an extract preferably in an amount of 0.001-10 wt.%. The extract is obtained by extracting Lycopus lucidus Turcz. preferably with a water-soluble organic solvent such as a monohydric alcohol or polyhydric alcohol or with a water-containing water-soluble organic solvent containing the water soluble organic solvent in an amount of >=50 wt.%.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair growth / hair restoration material, and more particularly, to an object of the invention is to provide a hair growth / hair restoration material having excellent hair growth / hair restoration effects and having sufficient safety for long-term use. It is.

[0002]

2. Description of the Related Art Conventionally provided hair growth and hair growth products contain various crude drug extracts or various compounds. For example, as a crude drug extract, extracts such as yokuinin, ginkgo, cashew and the like (Japanese Patent Publication No. 1-13451)
And compounds such as vitamin E, alloxazine, pyridine N-oxide, adenosine-3 ', 5'-cyclic monophosphate (see JP-A-64-56608). Gazette,
JP-A-1-261321, JP-A-2-20440
No. 6).

[0003]

However, the hair growth and hair growth materials provided so far include, as mentioned in the above examples,
Various crude drug extracts and various compounds have been applied, but few have a remarkable effect, and those having a certain effect are so stimulating that dermatitis is caused,
There are drawbacks such as difficulty in continuous use.

[0004] The present invention has been made in view of such circumstances, and provides a hair growth and fostering material that is excellent in hair growth and fostering effects and has sufficient safety to withstand long-term use. That is the task.

[0005]

Means for Solving the Problems The present inventors have conducted intensive studies in order to solve the above-mentioned problems, and as a result, an extract obtained by extracting from a specific plant belonging to the Labiatae under specific extraction conditions has been obtained. It has been found that it has excellent hair growth and hair growth effects and that there is no safety problem during use, and based on such findings, the present invention has been completed.

[0006] That is, the present invention preferably provides an extract obtained by extracting Syrone with a water-soluble organic solvent, preferably a monohydric alcohol or a polyhydric alcohol, or a water-containing water-soluble organic solvent containing 50% by weight or more of a water-soluble organic solvent. The present invention relates to a hair growth / hair restoration material characterized by containing 0.001 to 10% by weight.

[0007] The present invention also relates to a hair growth and fostering material further comprising a skin peripheral vasodilator in the above hair growth and fostering material.

Hereinafter, the present invention will be described in detail. First, syrone (scientific name: Lycopus lucidus Turc) applied to the present invention
z.) is a perennial plant belonging to the Labiatae distributed in Japan, China and western North America. Until now, dry matter of foliage of Shirone has been called Sawaran in Chinese medicine, and has been used for postpartum abdominal pain, bruises, cuts, etc. However, it has never been practically used as a cosmetic, and there has been no example in which the hair growth and hair growth effects have been directly verified, and this was first discovered by the present inventors.

Next, in order to obtain the extract according to the present invention from the above-mentioned plant, a plant obtained by drying or pulverizing the plant or a commercially available schiran is extracted with an extraction solvent such as methanol.
Monohydric alcohols such as ethanol, propanol and butanol; polyhydric alcohols such as 1,3-butylene glycol and propylene glycol; or water-soluble organic solvents such as acetone, tetrahydrofuran and dioxane; or the above monohydric alcohols, polyhydric alcohols or acetone Extraction is carried out using a water-containing water-soluble organic solvent containing 50% by weight or more of tetrahydrofuran, dioxane and the like, and it is particularly preferable to use monohydric alcohol or polyhydric alcohol.

As a specific method, 100 g of a plant is used in an extraction solvent of 0.5 to 5 l at a temperature from room temperature to the boiling point of the extraction solvent, at room temperature for 7 to 10 days, at heating for 4 to 8 hours, ~
Extract by digestion twice. These extracts are combined, filtered with suction, and then concentrated under reduced pressure to remove the solvent to obtain a viscous or dried extract. The obtained extract is dissolved or dispersed and diluted with an appropriate solvent or the like as it is, and then mixed with a base to obtain the hair growth and hair growth material of the present invention.

[0011] Here, the content of sylonnae extract contained as an active ingredient of the hair growth / hair restoration according to the present invention is preferably 0.001 to 10% by weight, particularly preferably 0.05%.
~ 5% by weight. When the content is less than 0.001% by weight, the hair growth effect is reduced, and when the content exceeds 10% by weight, the stability is reduced.

Next, the hair growth and hair growth agent of the present invention has a more preferable hair growth and hair growth effect when it contains a skin peripheral vasodilator in addition to the above-mentioned syrone extract. Such skin peripheral vasodilators include, for example, carpronium chloride, benzyl nicotinate, vitamin E, vitamin E acetate, vitamin E linoleate, vitamin E nicotinate, pepper tincture, etc., and one or more of these. Is used.

[0013] The hair growth and fostering composition of the present invention includes, in addition to the above-mentioned syrone extract and skin peripheral vasodilator, additives usually used for hair growth and fostering, such as hinokitiol,
Cationic surfactants, disinfectants such as parabens, cooling agents such as l-menthol, hydrocarbons, waxes, oils and fats, esters, higher fatty acids, oils such as higher alcohols, other surfactants, fragrances, dyes, Antioxidants, UV protection agents, alcohols, pH adjusters, water and the like can be added.

The hair growth and hair growth agent of the present invention includes various dosage forms, for example, hair tonic, shampoo, rinse, pomade, hair lotion, hair cream, hair treatment and the like, and is prepared according to a conventional method.

[0015]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Here, a production example of an extract according to the present invention will be described. Production Example 1. 100 g of dried whole plant of syrone is immersed in 1 liter of 95% by weight ethanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 3.0%)

Production Example 2 100 g of dried whole plant of Sirone was immersed and extracted in 1 liter of 75% by weight ethanol at room temperature for 10 days, the residue was separated by filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 3.2%)

Production Example 3 100 g of dried whole plant of Sirone was immersed and extracted with 1 liter of 55% by weight of ethanol at room temperature for 10 days, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 3.5%)

Production Example 4 100 g of dried whole plant of syrone is immersed in 1 liter of acetone, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.8%)

Production Example 5 100 g of dried whole plant of syrone was immersed in 1 liter of butanol and transferred to a Soxhlet extractor,
Perform warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.9%)

Production Example 6 100 g of dried whole plant of Shirone is immersed in 1 L of an extraction solvent of propylene glycol: distilled water = 1: 1 (weight ratio), transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.6%)

Comparative Production Example 1. Syrone's whole plant dried product 100
g was immersed and extracted with 1 l of 35% by weight ethanol at room temperature for 10 days, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (3.8% yield)

Comparative Production Example 2 Syrone's whole plant dried product 100
g was extracted with 1 l of 15% by weight ethanol at room temperature for 10 days, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 3.5%)

Comparative Production Example 3 Syrone's whole plant dried product 100
g was extracted with 1 l of a 5% by weight aqueous acetic acid solution at room temperature for 10 days, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.9%)

Comparative Production Example 4 Syrone's whole plant dried product 100
g was extracted with 1 l of ethyl acetate at room temperature for 10 days, and the residue was separated by filtration with filter paper. The filtrate was evaporated to dryness to obtain an extract. (1.9% yield)

Next, a comparative test was conducted on the effect of the extract thus obtained on hair growth in mice.

"Mouse Hair Growth Evaluation Test" (1) Sample Invention Product 1: 70% aqueous ethanol dispersion containing 5% syrone extract (Production Example 1) Invention Product 2: Syrone extract (Production Example 2) Inventive product 3: 70% aqueous ethanol dispersion containing 5% syrone extract (Preparation example 3) Inventive product 4: Syrone extract extract (Preparative example 4) 70% aqueous ethanol dispersion containing 5% Inventive product 5: 70% aqueous ethanol dispersion containing 5% of syrone extract (Preparation example 5) Inventive product 6: 5% of syrone extract (Preparative example 6) 70% ethanol aqueous dispersion containing

Comparative product 1: Syrone extract 5 (Comparative Production Example 1)
% Aqueous 70% ethanol aqueous dispersion Comparative product 2: 5 parts of syrone extract (Comparative Production Example 2)
%: 70% aqueous ethanol dispersion Comparative product 3: Syrone extract (Comparative Production Example 3)
% Aqueous 70% ethanol dispersion Comparative product 4: Syrone extract (Comparative Production Example 4)
% Aqueous solution containing 70% ethanol Comparative product 5: 70% aqueous ethanol dispersion containing 1% vitamin E Control: 70% aqueous ethanol solution

(2) Test Method Using 9-week-old C3H mice, one group consisted of 10
After making a group, these backs were shaved to a size of 2.0 x 2.0 cm, and the next day, 0.04 g of each sample was applied to the shaved area, and on the 16th day, the density of hair growth at the area was determined. The degree of increase in black color was evaluated using a color difference meter. Table 1 shows the results.

[0029]

[Table 1]

As is evident from the results in Table 1, the extract of syrone according to the present invention shows a large decrease in L value and an increase in blackness as compared with vitamin E of control and comparative product 5. I understand. This is presumed to be the result of the extract according to the present invention stimulating hair roots, increasing blood circulation around hair follicles, and activating metabolism. In addition, in the influence of the extraction solvent, the extractable fraction of less than 50% by weight of the water-soluble organic solvent and the fat-soluble extractable fraction of Comparative Products 1 to 4 contain little or no component promoting the hair growth effect. You can see that.

[0031]

The present invention will be further described with reference to the following examples.
In addition, the compounding amount is a weight part. Embodiments 1-3. Hair tonic Using the components and composition shown in Table 2 below, each component was heated and dissolved, and solubilized to prepare a hair tonic.

[0032]

[Table 2]

"Human hair growth / hair growth evaluation test" (1) Sample The present invention product: Hair tonic of Examples 1 to 3 Comparative product: Sirone extract (Production Example 2) was removed from the hair tonic of Example 1 (Increase water) Hair tonic

(2) Test method Twenty panelists complaining of alopecia and alopecia were divided into four groups of five each, and a long-term continuous test for 6 months was performed using each sample. The application method was a method of evenly applying the composition to the head twice a day as in the usual tonic usage. The evaluation was performed on the third and sixth months after the start of use, and the degree of increase in the number of test subjects who felt that the hairs and hairs had increased was measured. In addition, at the end of the test, they were asked to improve their scalp condition and reduce dandruff. Table 3 shows the results.

[0035]

[Table 3]

As is evident from the results in Table 3, the hair growth and growth stimulant of the present invention has a hair growth effect because the number of people who have developed alveoli and those who have hard hair have increased. Was done. Also, at the end of the test, three people in Example 1, two people in Example 2, and one person in Example 3 reported that the condition of the scalp was improved and the occurrence of dandruff was reduced. From this, the hair growth / hair growth material of the present invention was also confirmed to have a hair growth effect. Furthermore,
Since no scalp condition or skin disorder such as inflammatory reaction was observed in any of the panelists during the use test period, it was confirmed that the safety was high.

Embodiment 4 Hair tonic (A) Silone extract (Preparation example 1) 3.0 Menthol 0.2 Vitamin E 0.05 Carpronium chloride 0.1 (B) Ethanol 50.0 (C) Propylene glycol 5.0 Vitamin B2 0.5 Yeast extract (containing nucleic acid) 0.5 Glycyrrhizin dipotassium 0.3 Diphenhydramine hydrochloride 0.3 Methylparaben 0.2 (D) Purified water 39.75 (E) Fragrance 0.1

(Preparation method) (A) was dissolved in (B), and (D) and (E), in which (C) was dissolved, were added thereto to prepare a hair tonic.

Embodiment 5 Hair treatment (A) Liquid paraffin 2.0 Methylpolysiloxane (10 cs) 2.0 Cetanol 4.0 (B) Stearyltrimethylammonium chloride 3.0 Distearyldimethylammonium chloride 0.5 Propylene glycol 5.0 Silone extract (Production Example 6) 4.5 Pyroctone olamine 0.25 Purified water 40.0 (C) Hydrolyzed collagen 0.5 Hyaluronic acid 0.01 Bovine placenta extract 0.5 Purified water 37.19 Diphenhydramine hydrochloride 0.25 Methyl paraben 0.2 (D) Fragrance 0.1

(Preparation method) Each of (A) and (B) was
And emulsify by mixing them. Thereafter, the mixture was cooled to around 40 ° C., at which point (C) was added, and further (D) was added to prepare a hair treatment.

Embodiment 6 Hair shampoo (A) triethanolamine lauryl sulfate 10.0 sodium lauryl sulfate 5.0 coconut oil diethanolamide 2.0 propylene glycol 5.0 pyroctone olamine 0.25 benzyl nicotinate 0.1 Sirone extract (Preparation Example 4) 1.0 (B) trichlorocarbanilide 0.25 purification Water 76.3 (C) Fragrance 0.1

(Preparation method) (A) was mixed at 80 ° C., then cooled to about 40 ° C., (B) was added, and (C) was further added to prepare a hair shampoo.

Embodiment 7 Hair rinse (A) Liquid paraffin 0.5 Methylpolysiloxane (10 cs) 0.5 Cetanol 2.0 Stearyltrimethylammonium chloride 3.0 (B) 1,3-butylene glycol 5.0 Silone extract (Production Example 5) 2.0 Purified water 40.0 Diphenhydramine hydrochloride 0.25 (C) Glycyrrhizin Dipotassium 0.25 Purified water 46.4 (D) Fragrance 0.1

(Preparation method) (A) and (B) were each heated to 80 ° C.
And mixed at that point. Thereafter, the mixture was cooled to around 40 ° C., (C) was added, and (D) was further added to prepare a hair rinse.

Embodiment 8 FIG. Hair cream (A) Vaseline 7.0 Beeswax 8.0 Liquid paraffin 37.0 Polyoxyethylene (20E.O.) cetyl ether 3.0 Glyceryl monostearate 2.0 Vitamin E nicotinate 0.1 Sirone extract (Production example 3) 2.5 (B) Purified water 34.6 Propylene glycol 5.0 Diphenhydramine hydrochloride 0.2 Glycyrrhizin dipotassium 0.2 Ethyl paraben 0.3 (C) Fragrance 0.1

(Preparation method) (A) was mixed and dissolved at 80 ° C., and then (B) preheated to 80 ° C. was gradually added to (A) and emulsified. Thereafter, the mixture was cooled to 40 ° C., and (C) was added to prepare a hair cream.

The hair growth and hair growth effects of the present invention obtained in Examples 4 to 8 above were tested for hair growth and hair growth effects by the same method as in Examples 1 to 3, and all were excellent. No skin damage such as deterioration of the scalp condition and inflammatory reaction was observed at all.

[0048]

According to the present invention, it is possible to provide a hair-growth / hair-growing agent which has an excellent hair-growth / hair-growth effect and which is free from skin disorders due to long-term continuous use and which is excellent in safety.

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Hideo Kuroda 560 Pola, Kashio-cho, Totsuka-ku, Yokohama-shi, Kanagawa Prefecture Inside the Totsuka Research Laboratories Co., Ltd. Industrial Co., Ltd.

Claims (4)

[Claims] 1. A hair-growing / hair-growing agent characterized by comprising an extract extracted from syrone with a water-soluble organic solvent or a water-containing water-soluble organic solvent containing 50% by weight or more of a water-soluble organic solvent. 2. The hair growth and fostering composition according to claim 1, wherein the water-soluble organic solvent is a monohydric alcohol or a polyhydric alcohol. 3. The content of the extract is from 0.001 to 10
The hair growth and fostering material according to any one of claims 1 and 2, which is in terms of% by weight. 4. The hair growth and fostering composition according to claim 1, wherein the hair growth and fostering composition contains a skin peripheral vasodilator.