JPH0826942A - Hair tonic cosmetic - Google Patents

Abstract

PURPOSE:To obtain a hair tonic cosmetic, containing D(L)-pantolactone as an active ingredient, excellent in especially hair growth effect, preventing effects on both alopecia and keratonosis (dandruff) and having high safety. CONSTITUTION:This hair tonic cosmetic is obtained by blending 0.001-20wt.%, preferably 1-10wt.% D(L)-pantolactone as an active ingredient therein. The active ingredient is suitably blended with a usually used cosmetic base, a base for preparation for external use and other usually used additives and prepared as a hair tonic, a hair lotion, a hair cream, a pomade, a hair conditioner, a shampoo, a rinse, a hair gel, a hair mist, a hair foam, etc., for use. Side effects such as phytotoxicity are not caused even by use for a long period.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing cosmetic composition, and more particularly, it contains D (L) -pantolactone as an active ingredient, and especially has a hair-growing effect, a hair loss-preventing effect, and abnormal keratinization of the scalp. (Dandruff) The present invention relates to a hair nourishing cosmetic having an excellent preventive effect.

[0002]

2. Description of the Related Art The causes of hair loss known to date are:
Aging of scalp function and imbalance of metabolism, degeneration of sebaceous gland and growth of hair root part, that is, reduction of metabolism of hair papilla are mentioned. Therefore, in order to prevent hair loss and promote hair growth, the drug is effectively applied to the scalp, sebaceous glands, hair roots, hair matrix cells, etc., which are considered to be the cause of hair loss, to return to a normal shape, Conventionally, a blood circulation promoting substance or a cell entrapment substance has been used. Vitamin E derivatives, capsicum tincture, nicotinic acid derivatives are known as blood circulation promoting substances, and ginseng extract, senburi extract, licorice and the like are known as scavenging substances for skin cells of the scalp. However, the blood circulation-promoting substances that have been conventionally used have strong skin irritation and have a limited amount to be blended,
Continuous use is difficult due to secondary side effects,
There is a drawback that the duration of blood circulation promotion is short. Also,
The effect of cell entrapment is not sufficiently exerted.

On the other hand, pantolactone has optical isomers, and all of D-form, L-form, and DL-form are known, and they are known substances. It is completely unknown that (L) -pantolactone has a hair-growth effect, a hair loss prevention effect, and a dandruff prevention effect.

[0004]

The object of the present invention is to provide a hair growth effect, which is safe enough to withstand long-term use.
An object of the present invention is to provide a hair nourishing cosmetic excellent in hair loss prevention effect and dandruff prevention effect.

[0005]

[Means for Solving the Problems] In order to achieve the above-mentioned object, the inventors of the present invention have conducted extensive studies, and as a result, D (L) -pantolactone has an effect on hair growth, hair loss and dandruff. It was confirmed that the present invention is excellent and safe and has no side effects such as chemical damage even after long-term use, and the present invention has been completed based on these new findings. Hereinafter, the present invention will be described in detail.

The pantolactone used as the active ingredient in the present invention is industrially produced and easily available. Since this substance has an asymmetric carbon at the 2-position, optical isomers exist. The hair growth effect according to the present invention is D-body,
Although observed in the L-form and the DL-form, it is the D-form that is present in the natural product, its properties are well known, and it is preferable to use the D-form from the viewpoint of safety. However, since all the other isomers also have the properties as a hair restorer, these isomers can be sufficiently used as the active ingredient of the present invention, and the present invention is limited to a specific optical isomer. It is not limited to.

To prepare the hair nourishing cosmetic composition according to the present invention,
According to a conventional method for preparing cosmetics and external preparations, D (L) -pantolactone may be used as an active ingredient and formulated into various dosage forms of hair-growth cosmetics using commonly used cosmetic bases and external preparation bases. .

In preparing the hair nourishing cosmetic composition according to the present invention, the compounding amount of D (L) -pantolactone, which is an active ingredient, in the hair nourishing cosmetic composition is 0.001-based on the total amount.
20.00 wt% is sufficient, and more preferably 1.0
~ 10.0 wt%. That is, if the amount is less than the lower limit, the desired effect of the present invention cannot be sufficiently obtained, and if the amount exceeds the upper limit, it is impossible to expect the improvement of the effect commensurate with the increase.

Other raw material components used in the hair growth and hair restoration composition of the present invention include hydrocarbons, waxes, oils and fats, esters, higher fatty acids and higher alcohols which are usually applied to cosmetics. , Surfactants, moisturizers, fragrances, dyes, preservatives, antioxidants, UV protectors, pH adjusters, and medicinal ingredients suitable for the purpose of the present invention. Further, it may be used in combination with a publicly known and publicly used hair growth / hair growth ingredient. Further, the hair nourishing cosmetic of the present invention has various dosage forms, for example, hair tonic, hair lotion, hair cream, pomade, hair conditioner, shampoo, rinse,
Hair gel, hair mist, hair foam, etc. are mentioned.

Next, the function and effect of the hair nourishing cosmetic composition according to the present invention will be described in detail with reference to test examples.

[0011]

Test Example 1 With respect to the evaluation substances (Samples 1 and 2) having the formulations shown in Table 1 below, a hair growth effect test was conducted by an animal experiment using mice. A control substance containing no D-pantolactone was used as a control.

[0012]

[Table 1]

As the mice used in the experiment, male ddY mice of 5 weeks old were selected. First hair growth in mice is 3 after birth
It is said that it will start around 2-36 days and enter a rest period from 55-58 days after birth. Five-week-old mice are just in the second stage of early growth. 9 groups of mice for each sample
The animals were used.

The diameters of the left and right sides of the mouse are 1.5c, respectively.
After cutting hair with a hair clipper in a circle of m, completely remove it with a hair removal cream, leave it for 1 day, and apply the evaluation substances (samples 1 and 2) shown in Table 1 once a day to the left side and to the right side as a control. Apply substance (control). The coating amount was 0.1 ml in both cases.

At the end of administration for 2 weeks, about 50 hairs were randomly extracted from the hair removal part of each mouse, and the hair length of each mouse was microscopically examined under a magnification of 10 times with a caliper. Measured. The results obtained are shown in Table 2 below.

[0016]

[Table 2]

As is clear from the above results, the D-pantolactone used in the present invention was found to have a hair growth promoting effect.

[0018]

[Test Example 2] Using a hair lotion having the composition of Example 1 shown in Table 3 below, a hair growth / hair growth effect test by humans was carried out. As a control, D in the formulation of Example 1 was used.
The formulation of Comparative Example 1 in which L-pantolactone was not formulated was used.

[0019]

[Table 3]

A hair growth / hair growth effect test was carried out by allowing 20 panelists who complain of thinning hair and alopecia to use the hair lotion shown in Example 1 for 6 consecutive months. As a method of use, a method of evenly applying to the head twice a day was used as in the usual method of using hair lotion. The evaluation was performed 1 month and 3 months after the start of use, and the extent to which the number of subjects who felt that their vellus hair and terminal hair had increased increased was measured. At the end of the test, they were also asked to report improvements in their scalp condition and a reduction in the occurrence of dandruff. The obtained results are shown in Table 4 below.

[0021]

[Table 4]

As is clear from the above results, the hair lotion containing DL-pantolactone according to the present invention has an increased hair growth effect because the number of people who have downy hairs and those who have terminal hairs is increasing. Was recognized. In addition, the condition of the scalp was also improved, and 11 persons declared that the occurrence of dandruff was reduced. Especially, the dandruff prevention effect showed an improvement tendency effect in 5 to 10 days. From this, a hair-growing effect was also recognized in the hair lotion containing the DL-pantolactone of the present invention. During the use test period, no skin damage such as deterioration of scalp condition or inflammatory reaction was observed in any of the panelists, thus confirming that the present invention has high safety.

Next, prescription examples of the hair nourishing cosmetic composition according to the present invention will be shown as examples.

[0024]

[Example 1: Hair lotion] (Formulation) DL-pantolactone 5.0 Ethanol 30.0 Polyoxyethylene hydrogenated castor oil 0.5 1,3-butylene glycol 8.0 Purified water 56.5

[0025]

[Example 2: Hair tonic] (Formulation) L-pantolactone 10.0 Menthol 0.2 Moisturizer 20.0 Ethanol 40.0 Purified water total 100.0

[0026]

[Example 3: Hair tonic] (Formulation) D-pantolactone 1.0 Pantothenyl alcohol 0.3 Solubilizing agent 5.0 Perfume 0.1 Ethanol 40.0 Total amount with purified water 100.0

[0027]

[Example 4: Hair tonic] (Formulation) DL-pantolactone 5.0 β-glycyrrhetinic acid 0.1 Resorcin 0.2 Ethanol 40.0 Solubilizing agent 1.0 Moisturizing agent 5.0 Perfume 0.1 Purified water At 100.0

[0028]

[Example 5: Hair tonic] (Formulation) D-pantolactone 3.0 Sempuri extract solution 0.5 Water-soluble placenta extract 1.0 dl-α-tocopherol 0.2 Ethanol 40.0 Solubilizing agent 1.0 Moisturizing Agent 4.0 Fragrance 0.1 Total with purified water 100.0

[0029]

Example 6: Hair Cream (Formulation) DL-pantolactone 3.0 Stearic acid 1.0 Adsorption-purified lanolin 1.0 Squalane 2.0 Liquid paraffin 38.0 Polyoxyethylene cetyl ether (20 EO) 2 .0 polyoxyethylene cetyl ether (5EO) 2.0 sorbitan monostearate 1.5 preservative proper amount triethanolamine 1.0 sequestering agent proper amount moisturizer 5.0 perfume 0.2 in purified water Total 100.0

[0030]

The hair nourishing cosmetic composition containing D (L) -pantolactone of the present invention exhibits a hair growth effect in a hair growth test using mice, and further, in a practical use test for humans, hair growth is observed.・ Hair growth effect is observed, skin damage due to long-term continuous use is not observed, and it is also excellent in safety.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Tomohiro Suzuki 2-9, Nishikata, Bunkyo-ku, Tokyo (72) Inventor Tomoyasu Tashiro 1-6-1-519 Iwado Minami, Komae-shi, Tokyo (72) Inventor Manabu Katsumata 6-1-3 Minamirinma, Yamato City, Kanagawa Prefecture

Claims (1)

[Claims] 1. A hair nourishing cosmetic composition comprising D (L) -pantolactone as an active ingredient.