JP3853773B2 - Hair nourishing - Google Patents
Hair nourishing Download PDFInfo
- Publication number
- JP3853773B2 JP3853773B2 JP2003327328A JP2003327328A JP3853773B2 JP 3853773 B2 JP3853773 B2 JP 3853773B2 JP 2003327328 A JP2003327328 A JP 2003327328A JP 2003327328 A JP2003327328 A JP 2003327328A JP 3853773 B2 JP3853773 B2 JP 3853773B2
- Authority
- JP
- Japan
- Prior art keywords
- hair
- effect
- hair nourishing
- hair growth
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000004209 hair Anatomy 0.000 title claims description 53
- 244000290333 Vanilla fragrans Species 0.000 claims description 9
- 235000009499 Vanilla fragrans Nutrition 0.000 claims description 9
- 235000013399 edible fruits Nutrition 0.000 claims description 7
- 235000012036 Vanilla tahitensis Nutrition 0.000 claims description 5
- 230000001256 tonic effect Effects 0.000 claims description 4
- 241000233855 Orchidaceae Species 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 description 28
- 230000000694 effects Effects 0.000 description 22
- 230000003779 hair growth Effects 0.000 description 19
- 239000000341 volatile oil Substances 0.000 description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 238000012360 testing method Methods 0.000 description 11
- 230000017531 blood circulation Effects 0.000 description 10
- 239000003205 fragrance Substances 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 230000001737 promoting effect Effects 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 201000004384 Alopecia Diseases 0.000 description 7
- 208000001840 Dandruff Diseases 0.000 description 7
- 244000299461 Theobroma cacao Species 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- 235000009470 Theobroma cacao Nutrition 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 230000003662 hair growth rate Effects 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- 230000003658 preventing hair loss Effects 0.000 description 6
- 239000008213 purified water Substances 0.000 description 6
- 238000013329 compounding Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000003960 organic solvent Substances 0.000 description 5
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 4
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 4
- 239000000443 aerosol Substances 0.000 description 4
- KVYGGMBOZFWZBQ-UHFFFAOYSA-N benzyl nicotinate Chemical compound C=1C=CN=CC=1C(=O)OCC1=CC=CC=C1 KVYGGMBOZFWZBQ-UHFFFAOYSA-N 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 230000003676 hair loss Effects 0.000 description 4
- 208000024963 hair loss Diseases 0.000 description 4
- 239000006210 lotion Substances 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 244000046052 Phaseolus vulgaris Species 0.000 description 3
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- -1 n Species 0.000 description 3
- 210000004761 scalp Anatomy 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000000638 solvent extraction Methods 0.000 description 3
- 239000011550 stock solution Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- ZTQSAGDEMFDKMZ-UHFFFAOYSA-N Butyraldehyde Chemical compound CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical class OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical class CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 2
- 231100000360 alopecia Toxicity 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
- 229950004580 benzyl nicotinate Drugs 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 229960003720 enoxolone Drugs 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 239000003410 keratolytic agent Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 239000003915 liquefied petroleum gas Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 239000002453 shampoo Substances 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 238000001256 steam distillation Methods 0.000 description 2
- 229940124549 vasodilator Drugs 0.000 description 2
- 239000003071 vasodilator agent Substances 0.000 description 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- 229930008281 A03AD01 - Papaverine Natural products 0.000 description 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 1
- 238000011735 C3H mouse Methods 0.000 description 1
- 208000019300 CLIPPERS Diseases 0.000 description 1
- 229940127291 Calcium channel antagonist Drugs 0.000 description 1
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 description 1
- 235000002568 Capsicum frutescens Nutrition 0.000 description 1
- XZFRIPGNUQRGPI-WLPVIMDJSA-N Carbacyclin Chemical compound C1\C(=C\CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 XZFRIPGNUQRGPI-WLPVIMDJSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 239000011627 DL-alpha-tocopherol Substances 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- ILKBHIBYKSHTKQ-UHFFFAOYSA-N Diisopropylamine dichloroacetate Chemical compound OC(=O)C(Cl)Cl.CC(C)NC(C)C ILKBHIBYKSHTKQ-UHFFFAOYSA-N 0.000 description 1
- 102000001399 Kallikrein Human genes 0.000 description 1
- 108060005987 Kallikrein Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 150000001204 N-oxides Chemical class 0.000 description 1
- 241001247145 Sebastes goodei Species 0.000 description 1
- 229940122511 Sebum inhibitor Drugs 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 1
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 1
- MSCCTZZBYHQMQJ-AZAGJHQNSA-N Tocopheryl nicotinate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C1=CC=CN=C1 MSCCTZZBYHQMQJ-AZAGJHQNSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 229960004373 acetylcholine Drugs 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229960005305 adenosine Drugs 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229960002298 aminohydroxybutyric acid Drugs 0.000 description 1
- 206010068168 androgenetic alopecia Diseases 0.000 description 1
- 230000002280 anti-androgenic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000000051 antiandrogen Substances 0.000 description 1
- 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- IZJRISIINLJVBU-UHFFFAOYSA-N beta-Butoxyethyl nicotinate Chemical compound CCCCOCCOC(=O)C1=CC=CN=C1 IZJRISIINLJVBU-UHFFFAOYSA-N 0.000 description 1
- 150000001996 bisabolol derivatives Chemical class 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 235000001046 cacaotero Nutrition 0.000 description 1
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 208000021930 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids Diseases 0.000 description 1
- DERZBLKQOCDDDZ-JLHYYAGUSA-N cinnarizine Chemical compound C1CN(C(C=2C=CC=CC=2)C=2C=CC=CC=2)CCN1C\C=C\C1=CC=CC=C1 DERZBLKQOCDDDZ-JLHYYAGUSA-N 0.000 description 1
- 229960000876 cinnarizine Drugs 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 229940084113 diisopropylamine dichloroacetate Drugs 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
- FODTZLFLDFKIQH-FSVGXZBPSA-N gamma-Oryzanol (TN) Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)O[C@@H]2C([C@@H]3CC[C@H]4[C@]5(C)CC[C@@H]([C@@]5(C)CC[C@@]54C[C@@]53CC2)[C@H](C)CCC=C(C)C)(C)C)=C1 FODTZLFLDFKIQH-FSVGXZBPSA-N 0.000 description 1
- YQGDEPYYFWUPGO-UHFFFAOYSA-N gamma-amino-beta-hydroxybutyric acid Chemical compound [NH3+]CC(O)CC([O-])=O YQGDEPYYFWUPGO-UHFFFAOYSA-N 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 235000020710 ginseng extract Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 239000012676 herbal extract Substances 0.000 description 1
- OIKBVOIOVNEVJR-UHFFFAOYSA-N hexadecyl 6-methylheptanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCC(C)C OIKBVOIOVNEVJR-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000008099 melanin synthesis Effects 0.000 description 1
- 229960003632 minoxidil Drugs 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 150000002826 nitrites Chemical class 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 150000002948 pantothenic acids Chemical class 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 229960001789 papaverine Drugs 0.000 description 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229940093430 polyethylene glycol 1500 Drugs 0.000 description 1
- 229940113115 polyethylene glycol 200 Drugs 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000003405 preventing effect Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 1
- 229960001755 resorcinol Drugs 0.000 description 1
- 230000005070 ripening Effects 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000004215 skin function Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
- 235000019982 sodium hexametaphosphate Nutrition 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 229950009883 tocopheryl nicotinate Drugs 0.000 description 1
- HGBOYTHUEUWSSQ-UHFFFAOYSA-N valeric aldehyde Natural products CCCCC=O HGBOYTHUEUWSSQ-UHFFFAOYSA-N 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Description
本発明は、養毛料に関し、更に詳しくは、育毛、養毛、脱毛予防、ふけ防止等の効果に優れた養毛料に関する。本発明の養毛料は、具体的には、医薬品、医薬部外品又は化粧品の分野において利用される。 The present invention relates to a hair nourishing agent, and more particularly to a hair nourishing agent excellent in effects such as hair growth, hair nourishing, hair loss prevention, anti-dandruff and the like. Specifically, the hair nourishing agent of the present invention is used in the fields of pharmaceuticals, quasi drugs, and cosmetics.
一般的に、脱毛症は血行の不全、毛母細胞活性の低下や性ホルモンのアンバランス等の様々な要因が複雑に絡み合って生じていると考えられている。特に現代社会は高齢化社会、ストレス社会と言われるように、様々な原因によって脱毛の危機にさらされる機会が多くなっている。しかし、脱毛の発生機作やメカニズムが未だ十分に解明されていないのが現状である。従来の養毛料には養毛、育毛効果が期待される薬効成分として、例えば、トウガラシチンキ、センブリエキス、朝鮮ニンジンエキス、ニコチン酸誘導体等の頭皮の血行促進物質、セファランチン等の皮膚機能亢進物質、アセチルコリン誘導体等の血管拡張剤、男性ホルモンを抑制するためにエストラジオール等の女性ホルモン剤、パントテン酸誘導体等のメラニン合成触媒剤、サリチル酸、レゾルシン等の角質溶解剤、皮脂分泌過剰などによる皮膚炎症を抑制するためにグリチルレチン酸、シコンエキス等の抗炎症剤が配合され、脱毛の予防や治療に用いられている。しかしながら、これらの薬剤は、場合によっては皮膚刺激を引き起こしたりするため、配合量に制限があったり、十分な育毛、脱毛防止、ふけ防止等の効果が発現する効果が充分でなく、問題点が残されているのが現状である。 In general, alopecia is considered to be caused by complex intertwining of various factors such as blood circulation failure, decreased hair matrix cell activity and sex hormone imbalance. In particular, the modern society is exposed to the risk of hair loss due to various causes, as it is said to be an aging society and a stress society. However, the mechanism and mechanism of hair loss have not been fully elucidated yet. Conventional hair nourishing agents are expected to have hair growth and hair-growth effects, for example, chili pepper tincture, assembly extract, ginseng extract, nicotinic acid derivative and other scalp blood circulation promoting substances, cephalanthin and other skin function enhancing substances, Suppresses skin inflammation caused by vasodilators such as acetylcholine derivatives, female hormone agents such as estradiol to suppress male hormones, melanin synthesis catalyst agents such as pantothenic acid derivatives, keratolytic agents such as salicylic acid and resorcin, and excessive sebum secretion Therefore, anti-inflammatory agents such as glycyrrhetinic acid and sicon extract are blended and used for the prevention and treatment of hair loss. However, since these drugs may cause skin irritation in some cases, there are limitations on the blending amount, and sufficient effects such as hair growth, hair loss prevention, dandruff prevention are not sufficient, and there are problems. What is left is the current situation.
そこで最近では各種天然物から溶媒抽出を行い、そのエキスを養毛・育毛剤に配合するものが多くみられてきた。生薬から水溶性有機溶媒単独またはこれらの含水有機溶媒により抽出した有効成分を含有させるものや(例えば、特許文献1参照)、数種の科において限定した植物の中から少なくとも二つの科の植物抽出液を含有させているものもある(例えば、特許文献2参照)。また、薬用植物の抽出物を1種以上配合した皮脂抑制剤(例えば、特許文献3参照)、多種の薬用天然物を特定割合で混合し、エタノール及び酢酸含有水溶液に浸して調整した養毛剤(例えば、特許文献4参照)が提案されている。このように、養毛・育毛効果を有する物質として多種多様のものが提案されているが、これらの従来の養毛・育毛は副作用が生じたり、また養毛・育毛が必ずしも十分ではなく、より効果的な養毛・育毛剤の開発が望まれている。 In recent years, therefore, there have been many cases in which solvent extraction is performed from various natural products, and the extract is blended with a hair nourishing agent. Those containing active ingredients extracted from crude drugs with water-soluble organic solvents alone or those containing water-containing organic solvents (see, for example, Patent Document 1), and plant extraction of at least two families from among plants restricted in several families Some contain liquid (see, for example, Patent Document 2). In addition, a sebum inhibitor containing one or more medicinal plant extracts (for example, see Patent Document 3), a variety of medicinal natural products mixed at a specific ratio, and a hair nourishing agent prepared by soaking in an aqueous solution containing ethanol and acetic acid (for example, , See Patent Document 4). As described above, various substances have been proposed as substances having a hair-restoring / hair-restoring effect, but these conventional hair-restoration / hair-restoring have side effects, and hair-restoration / hair-restoration is not always sufficient. Development of an effective hair nourishing and hair restorer is desired.
本発明の目的とするところは、脱毛症に対して優れた脱毛予防効果及び育毛作用を有する養毛化粧料を提供することにある。そして、育毛、養毛、脱毛予防、ふけ防止等の効果に優れた育毛料を提供することにある。 An object of the present invention is to provide a hair nourishing cosmetic having an effect of preventing hair loss and a hair-restoring action with respect to alopecia. And it is providing the hair growth material excellent in effects, such as hair growth, hair growth, hair loss prevention, and dandruff prevention.
本発明者等は、上記目的を達成するために、鋭意研究を重ねた結果、各種植物由来の香料組成物の中でも、特定の香料組成物が、毛成長促進に優れた効果を示し、ふけ防止予防効果にも著効を呈することを見出して本発明を完成するに至った。 As a result of intensive studies to achieve the above object, the present inventors have shown that, among the fragrance compositions derived from various plants, the specific fragrance composition has an excellent effect on promoting hair growth and prevents dandruff. The present invention was completed by finding that the preventive effect is also significant.
即ち、本発明は、ラン科バニラ プラニフォリア(Vanilla planifolia)の果実(さや)から得られる精油及びアオギリ科セオブロマ カカオ リンネ(Theobroma cacao L.)の豆または果実から得られる精油からなる群より選ばれる少なくとも一種以上の精油を含有することを特徴とする養毛料にある。 That is, the present invention is at least selected from the group consisting of an essential oil obtained from the fruit (sheath) of the orchidaceae Vanilla planifolia and an essential oil obtained from the beans or the fruit of Theobroma cacao L. It exists in the hair nourishing agent characterized by containing 1 or more types of essential oil.
本発明により、顕著な毛成長促進効果を示し、育毛効果及び脱毛予防効果に優れ、溶解性及び使用感触に優れた養毛料を提供することができる。 According to the present invention, it is possible to provide a hair nourishing agent that exhibits a remarkable hair growth promoting effect, is excellent in a hair growth effect and a hair loss prevention effect, and is excellent in solubility and feel.
以下、本発明の実施形態について詳述する。本発明に用いる植物はいずれも香料原料として用いられているものである。 Hereinafter, embodiments of the present invention will be described in detail. All the plants used in the present invention are used as perfume raw materials.
本発明に用いるラン科バニラ プラニフォリア(Vanilla planifolia)の果実(さや)から得られる精油(以下、バニラ精油と呼ぶ)は、香気成分としてバニリン、ベンズアルデヒド等が含まれている。好ましくは果実(さや)を乾燥熟成した後に有機溶剤抽出法や水蒸気蒸留法によって得ることができる。また、通常市販されている香料組成物をそのまま、或いは蒸留等によって精製した後に使用することも可能である。好ましくはヘキサン、ペンタン、ベンゼン、石油エーテルなどの有機溶媒を用い抽出し、溶媒を除去し得るたものである。 The essential oil (hereinafter referred to as vanilla essential oil) obtained from the fruits of the orchidaceae vanilla planifolia (vanilla planifolia) used in the present invention contains vanillin, benzaldehyde, and the like as aromatic components. Preferably, it can be obtained by drying and ripening the fruit (spods) by an organic solvent extraction method or a steam distillation method. It is also possible to use a commercially available fragrance composition as it is or after purification by distillation or the like. Preferably, extraction is performed using an organic solvent such as hexane, pentane, benzene, petroleum ether, and the solvent can be removed.
本発明に用いるアオギリ科セオブロマ カカオ リンネ(Theobroma cacao L.)の豆または果実,から得られる精油(以下、カカオ精油と呼ぶ)は、香気成分としてブチルアルデヒド、リナロール、イロン等が含まれていることが知られている。一般的には果実の中の豆を取りだし発酵乾燥させた後、溶剤抽出法または水蒸気蒸留法によって得ることができる。また、通常市販されている香料組成物をそのまま、或いは蒸留等によって精製した後に使用することも可能である。好ましくは、ヘキサン、ペンタン、ベンゼン、石油エーテルなどの有機溶媒を用い抽出し、溶媒を除去し得たものである。 The essential oil (hereinafter referred to as cacao essential oil) obtained from beans or fruits of Theobroma cacao L. used in the present invention contains butyraldehyde, linalool, Iron and the like as aromatic components. It has been known. Generally, it can be obtained by taking out beans from the fruit and fermenting and drying them, followed by solvent extraction or steam distillation. It is also possible to use a commercially available fragrance composition as it is or after purification by distillation or the like. Preferably, it can be extracted using an organic solvent such as hexane, pentane, benzene, petroleum ether, and the solvent can be removed.
これらの精油は、それぞれ単独で用いることができるし、また2種を組み合わせて用いることができる。また、養毛料への配合量は、好ましくは、0.001〜5.0質量%(以下、%とする)であり、更に好ましくは0.01〜1.0%である。これら精油の配合量が0.001%未満では本発明の目的とする効果が十分に得られない場合があり、また、配合量が5.0%を越えても、その増加分に見合った効果の向上は望めなかったり、使用時に匂いが強く好ましくない。 These essential oils can be used alone or in combination of two kinds. The blending amount in the hair nourishing agent is preferably 0.001 to 5.0% by mass (hereinafter referred to as%), more preferably 0.01 to 1.0%. If the blending amount of these essential oils is less than 0.001%, the intended effect of the present invention may not be sufficiently obtained, and even if the blending amount exceeds 5.0%, an effect commensurate with the increase. It is not desirable to improve the odor, or the smell is strong during use.
また、本発明においては、更に血流促進剤を配合し、バニラ精油、カカオ精油等の香料組成物と血流促進剤とを併用することによって、より発毛促進効果を増大させることができる。血流促進剤は、それを皮膚上に塗布すると、血流が促進され、かつ外用剤の配合成分として安全性上問題がない限り、特に限定されるものではなく、その作用機序も問われるべきものではない。具体的には、ジイソプロピルアミンジクロロアセテート、γ−アミノ酪酸、γ−アミノ−β−ヒドロキシ酪酸、ニコチン酸ベンジル,ニコチン酸トコフェロール,ニコチン酸β−ブトキシエチル,ニコチン酸アミド等のニコチン酸誘導体、ミノキシジル並びにその誘導体及びその類縁体、セファランチン、ビタミンE及びその誘導体、γ−オリザノール、アルコキシカルボニルピリジンN−オキシド、塩化カプロニウム、ア
セチルコリン及びその誘導体、末梢血行障害治療薬(プロスタグランジン、カルバシクリン、パパベリン、シクランデレート、シンナリジン、ナイリドリン、カリクレイン)、カルシウム拮抗剤、ホスホジエステラーゼ阻害剤、亜硝酸化合物、アデノシン作用増強性血管拡張薬、ヒドラジン等の従来から血流促進剤として使用されているものを適宜選択することができる。また、これらの血流促進剤を単独で本発明の養毛料に配合することも可能であるが、2種以上を組み合わせて配合することも可能である。本発明の養毛料においては、上記の血流促進剤は、養毛料全体に対して0.001〜5.0%の範囲で配合されるのが好ましく、同0.01〜2.0%の範囲で配合されるのが特に好ましい。血流促進剤の配合量が養毛料全体に対して5.0%を超えると、皮膚刺激等が伴う等、安全性の側面から問題が生じる恐れがあり好ましくない。
In the present invention, the hair growth promoting effect can be further increased by further blending a blood flow promoting agent and using a perfume composition such as vanilla essential oil and cocoa essential oil together with the blood flow promoting agent. The blood flow promoting agent is not particularly limited as long as the blood flow is promoted when applied to the skin, and there is no safety problem as a compounding component of the external preparation, the action mechanism is also questioned. It shouldn't be. Specifically, nicotinic acid derivatives such as diisopropylamine dichloroacetate, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, benzyl nicotinate, tocopherol nicotinate, β-butoxyethyl nicotinate, nicotinamide, minoxidil and Derivatives and analogs thereof, cephalanthin, vitamin E and derivatives thereof, γ-oryzanol, alkoxycarbonylpyridine N-oxide, capronium chloride, acetylcholine and derivatives thereof, peripheral blood circulation disorders (prostaglandins, carbacyclin, papaverine, cyclande Rate, cinnarizine, nyridrin, kallikrein), calcium antagonists, phosphodiesterase inhibitors, nitrites, adenosine potentiating vasodilators, hydrazine, etc. What is used can be selected as appropriate. Moreover, although these blood flow promoters can be blended alone in the hair nourishing agent of the present invention, they can be blended in combination of two or more. In the hair nourishing agent of the present invention, the blood flow promoter is preferably blended in the range of 0.001 to 5.0% with respect to the entire hair nourishing agent, and 0.01 to 2.0% of the same. It is particularly preferable to blend in a range. If the blending amount of the blood flow promoter exceeds 5.0% with respect to the whole hair nourishing agent, it may cause problems from the viewpoint of safety such as skin irritation and the like.
本発明の養毛料は、種々の形態で用いることができ、例えば、ヘアートニック、ヘアーローション、ヘアークリーム、シャンプー、リンス、ヘアーフォーム、ヘアージェル、エアゾール等の直接頭皮に塗布する剤形に配合し、常法に従い製造することができる。 The hair nourishing agent of the present invention can be used in various forms, for example, blended into a dosage form to be applied directly to the scalp such as hair tonic, hair lotion, hair cream, shampoo, rinse, hair foam, hair gel, aerosol, etc. Can be produced according to a conventional method.
また、本発明の養毛料には、前記の各成分に加えて必要に応じて、かつ本発明の効果を損なわない範囲において、化粧品、医薬部外品、医薬品等において一般的に用いられる各種の成分、例えば、油分、保湿剤、増粘剤、色素、香料、殺菌剤、防腐剤、紫外線吸収剤、溶剤、水、角質溶解剤、抗炎症剤、抗アンドロゲン剤、養毛剤、抗酸化剤、清涼剤、生薬抽出物やビタミン類等を適宜配合することができる。 In addition to the above-mentioned components, the hair nourishment of the present invention is variously used in cosmetics, quasi-drugs, pharmaceuticals, etc. as necessary and within the range not impairing the effects of the present invention. Ingredients such as oils, moisturizers, thickeners, dyes, fragrances, bactericides, preservatives, UV absorbers, solvents, water, keratolytic agents, anti-inflammatory agents, antiandrogens, hair nourishing agents, antioxidants, refreshing Agents, herbal extracts, vitamins and the like can be appropriately blended.
以下、実施例により本発明を具体的に説明するが、これらの実施例により本発明の技術範囲が限定されるものではない。尚、実施例に記載の発毛促進効果試験及びヒト実用試験に関する試験法を下記に示す。 EXAMPLES Hereinafter, although an Example demonstrates this invention concretely, the technical scope of this invention is not limited by these Examples. In addition, the test method regarding the hair growth acceleration | stimulation effect test described in an Example and a human practical use test is shown below.
(1)発毛促進効果試験
C3Hマウス(8週齢、オス、平均重量35g)の背部皮膚(2cm×4cm)を電気バリカン及びシェーバーで刈り、翌日より実施例及び比較例の各試料を被験部皮膚に朝夕2回、一匹当り0.2mLを二週間連用塗布した。一試料に対して動物一群10匹使用した。塗布開始22日目に各試料の被験部皮膚をビデオカメラに撮影し、画像解析装置にて毛刈り部及び発毛部の面積を測定した。養毛効果の判定は、下記に示す発毛率(%)を算出し、実施例または比較例の各群の発毛率平均値を求めて比較を行った。
発毛率(%)=(発毛部の面積)/(毛刈り部の面積)×100
(1) Hair growth promotion effect test The back skin (2 cm × 4 cm) of C3H mice (8 weeks old, male, average weight 35 g) was cut with an electric clipper and a shaver, and each sample of Examples and Comparative Examples was tested from the next day. The skin was applied twice a day in the morning and evening for 0.2 weeks. A group of 10 animals was used for one sample. On the 22nd day from the start of application, the skin of the test area of each sample was photographed with a video camera, and the areas of the hair cutting part and the hair growth part were measured with an image analyzer. The determination of the hair nourishing effect was carried out by calculating the hair growth rate (%) shown below, and comparing the average hair growth rate of each group of the examples or comparative examples.
Hair growth rate (%) = (Area of hair growth part) / (Area of hair cutting part) × 100
(2)ヒト実用試験
男性型脱毛症患者である被験者10名の頭部の耳の上5cmの位置について、頭髪を左右2ヶ所に於いて直径5mmの円形状に剃毛し、実施例及び比較例の各試料を左側の頭髪全体に毎日朝夕2回、約3mL塗布し、右側には何も塗布せず、左右の比較を行った。毛成長速度の効果の判定は、試験開始後1ヶ月目に、左右の剃毛した部位の被験部毛髪20本を抜毛し、下記式で求めた値で毛成長速度を評価した。
毛成長速度=(左側の毛髪20本の長さの平均)÷(右側の毛髪20本の長さの平均)
また、育毛効果、脱毛効果、ふけ防止効果の判定は、試験開始後3ヶ月目に、各項に対して、右側の何も塗布していない被試部位と比較して、「産毛が剛毛化した或いは産毛が増加した」、「抜け毛が少なくなった」、「ふけが少なくなった」と回答した人数で示した。
(2) Human Practical Test About the position of 5 cm above the ears of the heads of 10 subjects who are male pattern baldness patients, the hair was shaved into a circular shape with a diameter of 5 mm at two left and right sides, and examples and comparisons About 3 mL of each sample of the example was applied to the entire left hair twice a day in the morning and evening, and nothing was applied to the right side, and the left and right were compared. In the determination of the effect of the hair growth rate, the hair growth rate was evaluated with the value obtained by the following formula after removing 20 test part hairs at the left and right shaved sites 1 month after the start of the test.
Hair growth rate = (average length of 20 left hairs) ÷ (average length of 20 right hairs)
In addition, the hair growth effect, hair removal effect, and anti-dandruff effect were determined by comparing the test results on the right side with the test site where nothing was applied on the right side in the third month after the start of the test. The number of respondents who responded that “they had increased hair production”, “has lost hair loss”, or “had less dandruff”.
実施例1〜4、比較例1〜3
表1に示す処方の養毛料を常法に従って作成し、前記の諸試験を実施して評価を行った。その結果を併せて表1に示す。
Examples 1-4, Comparative Examples 1-3
A hair nourishing agent having the formulation shown in Table 1 was prepared according to a conventional method, and the above tests were conducted for evaluation. The results are also shown in Table 1.
表1から明らかなように、本発明の養毛料は、比較例と比べて明らかに育毛、養毛、脱毛予防、ふけ防止のいずれの評価においても優れていた。 As is apparent from Table 1, the hair nourishing agent of the present invention was clearly superior in all evaluations of hair growth, hair nourishment, hair loss prevention, and dandruff prevention as compared with the comparative example.
実施例5(トニック)
配合量(%)
(1)95%エタノール 90.0
(2)バニラ精油 0.5
(3)ニコチン酸ベンジル 0.05
(4)酢酸α−DL−トコフェロール 0.5
(5)プロピレングリコール 1.0
(6)ポリエチレングリコール200 1.0
(7)香料 0.1
(8)色素 適 量
(9)精製水 残 部
Example 5 (Tonic)
Compounding amount (%)
(1) 95% ethanol 90.0
(2) Vanilla essential oil 0.5
(3) Benzyl nicotinate 0.05
(4) Acetic acid α-DL-tocopherol 0.5
(5) Propylene glycol 1.0
(6) Polyethylene glycol 200 1.0
(7) Fragrance 0.1
(8) Dye proper amount
(9) Purified water balance
(製法)(1)に、(2)〜(7)を溶解し、次いで(8)〜(9)を溶解させたものを添加し、攪拌することにより、透明液状のトニックを得た。 (Manufacturing method) To (1), (2) to (7) were dissolved, then (8) to (9) were added and stirred to obtain a transparent liquid tonic.
実施例6(養毛ローション)
配合量(%)
(1)95%エタノール 80.0
(2)バニラ精油 0.2
(3)カカオ精油 0.1
(4)ニコチン酸アミド 0.5
(5)セファランチン 0.01
(6)ジプロピレングリコール 2.0
(7)リン酸ニナトリウム 0.08
(8)リン酸一カリウム 0.02
(9)L−メントール 0.3
(10)香料 0.05
(11)水素添加ビサボロール 0.5
(12)精製水 残 部
Example 6 (hair growth lotion)
Compounding amount (%)
(1) 95% ethanol 80.0
(2) Vanilla essential oil 0.2
(3) Cocoa essential oil 0.1
(4) Nicotinamide 0.5
(5) Cephalanthin 0.01
(6) Dipropylene glycol 2.0
(7) Disodium phosphate 0.08
(8) Monopotassium phosphate 0.02
(9) L-menthol 0.3
(10) Fragrance 0.05
(11) Hydrogenated bisabolol 0.5
(12) Balance of purified water
(製法)(1)に(2)〜(6)、(9)、(10)及び(11)を溶解させた。次いで(12)に(7)〜(8)を溶解させたものと混合攪拌し、透明液状の養毛ローションを得た。 (Production Method) (2) to (6), (9), (10) and (11) were dissolved in (1). Subsequently, it mixed and stirred with what dissolved (7)-(8) in (12), and obtained the transparent liquid hair nourishing lotion.
実施例7(エアゾール養毛料)
配合量(%)
<原液処方>
(1)95%エタノール 50.0
(2)グリチルレチン酸 0.1
(3)カカオ精油 0.2
(4)センブリエキス 2.0
(5)ラウリル硫酸ナトリウム 0.1
(6)ポリオキシエチレン(40)硬化ヒマシ油 0.5
(7)乳酸 適 量
(8)乳酸ナトリウム 適 量
(9)香料 適 量
(10)色素 微 量
(11)精製水 残 部
<充填処方>
(12)原液 50.0
(13)液化石油ガス 50.0
Example 7 (aerosol hair nourishing agent)
Compounding amount (%)
<Undiluted solution formulation>
(1) 95% ethanol 50.0
(2) Glycyrrhetinic acid 0.1
(3) Cocoa essential oil 0.2
(4) Assembly extract 2.0
(5) Sodium lauryl sulfate 0.1
(6) Polyoxyethylene (40) hydrogenated castor oil 0.5
(7) Lactic acid appropriate amount (8) Sodium lactate appropriate amount (9) Fragrance appropriate amount (10) Dye amount (11) Purified water balance <Filling formula>
(12) Stock solution 50.0
(13) Liquefied petroleum gas 50.0
(製法)原液処方の各成分を混合溶解させて原液を調製し、これを缶に充填し、バルブ装着後、液化石油ガスを充填してエアゾール養毛料を調製した。 (Manufacturing method) Each component of the stock solution formulation was mixed and dissolved to prepare a stock solution, which was filled in a can, and after mounting a valve, liquefied petroleum gas was filled to prepare an aerosol hair nourishing agent.
実施例8(乳液型養毛料)
配合量(%)
<A相>
(1)カカオ精油 0.2
(2)ポリオキシエチレン(60)硬化ヒマシ油 2.0
(3)グリセリン 10.0
(4)ジプロピレングリコール 10.0
(5)1,3−ブチレングリコール 5.0
(6)ポリエチレングリコール1500 5.0
<B相>
(7)セチルイソオクタネート 10.0
(8)スクワラン 5.0
(9)ワセリン 2.0
(10)プロピルパラベン 2.0
<C相>
(11)カルボキシビニルポリマー1%水溶液 30.0
(12)ヘキサメタリン酸ソーダ 0.03
(13)精製水 8.0
<D相>
(14)精製水 5.0
<E相>
(15)水酸化カリウム 0.12
(16)精製水 残 部
Example 8 (Emulsion type hair nourishing agent)
Compounding amount (%)
<A phase>
(1) Cocoa essential oil 0.2
(2) Polyoxyethylene (60) hydrogenated castor oil 2.0
(3) Glycerin 10.0
(4) Dipropylene glycol 10.0
(5) 1,3-butylene glycol 5.0
(6) Polyethylene glycol 1500 5.0
<Phase B>
(7) Cetyl isooctanoate 10.0
(8) Squalane 5.0
(9) Vaseline 2.0
(10) Propylparaben 2.0
<Phase C>
(11) Carboxyvinyl polymer 1% aqueous solution 30.0
(12) Sodium hexametaphosphate 0.03
(13) Purified water 8.0
<Phase D>
(14) Purified water 5.0
<Phase E>
(15) Potassium hydroxide 0.12
(16) Balance of purified water
(製法)A相及びB相をそれぞれ70℃で加熱溶解し、混合してホモミキサー処理し、ゲルを調製した。このゲルにD相を徐々に添加してホモミキサーで分散させた。次に、このゲル分散物に予め溶解させたC相を添加し、さらに予め溶解させたE相を添加してホモミキサーで乳化し乳液型の養毛料を製造した。 (Manufacturing method) Each of the A phase and the B phase was heated and dissolved at 70 ° C, mixed and homomixed to prepare a gel. Phase D was gradually added to this gel and dispersed with a homomixer. Next, phase C dissolved in advance in this gel dispersion was added, phase E dissolved in advance was further added and emulsified with a homomixer to produce an emulsion type hair nourishing agent.
本発明により、ヘアートニック、ヘアーローション、ヘアークリーム、シャンプー、リンス、ヘアーフォーム、ヘアージェル、エアゾール等の直接頭皮に塗布する種々の形態で用いることができる、顕著な毛成長促進効果を示し、育毛効果及び脱毛予防効果に優れ、溶解性及び使用感触に優れた養毛料を提供することができる。 According to the present invention, it exhibits a remarkable hair growth promoting effect that can be used in various forms applied directly to the scalp, such as hair nick, hair lotion, hair cream, shampoo, rinse, hair foam, hair gel, aerosol, etc. It is possible to provide a hair nourishing agent that is excellent in effect and hair removal preventing effect, and that is excellent in solubility and use feeling.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003327328A JP3853773B2 (en) | 2003-09-19 | 2003-09-19 | Hair nourishing |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003327328A JP3853773B2 (en) | 2003-09-19 | 2003-09-19 | Hair nourishing |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005089395A JP2005089395A (en) | 2005-04-07 |
JP3853773B2 true JP3853773B2 (en) | 2006-12-06 |
Family
ID=34457218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003327328A Expired - Lifetime JP3853773B2 (en) | 2003-09-19 | 2003-09-19 | Hair nourishing |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP3853773B2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5300480B2 (en) * | 2005-09-23 | 2013-09-25 | シャネル パルファン ボーテ | Vanilla planifolia extract, extraction process thereof, and cosmetic composition or dermatological composition containing the same |
US8709502B2 (en) * | 2005-09-23 | 2014-04-29 | Chanel Parfums Beaute | Extract of Vanilla planifolia |
FR2912310B1 (en) * | 2007-02-13 | 2009-08-07 | Kasan Sarl | NOVEL COSMETIC AND / OR PHARMACEUTICAL COMPOSITIONS AND THEIR APPLICATIONS. |
KR101063574B1 (en) * | 2008-07-22 | 2011-09-07 | (주)아모레퍼시픽 | Cosmetic composition for hair containing black beans |
-
2003
- 2003-09-19 JP JP2003327328A patent/JP3853773B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2005089395A (en) | 2005-04-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2007204426A (en) | Hair growth promoter | |
JP2006306791A (en) | Hair growth-stimulating agent | |
JP3220761B2 (en) | Hair restoration | |
JP3563449B2 (en) | Hair restoration cosmetics | |
JP3853773B2 (en) | Hair nourishing | |
JP2003095843A (en) | Nonaqueous cosmetic | |
JP4032246B2 (en) | White hair prevention and improvement agent | |
JP4469617B2 (en) | Hair restoration | |
JP2002080327A (en) | Hair grower | |
JP3808412B2 (en) | Hair nourishing | |
JP2005089392A (en) | Hair tonic | |
JP2001192322A (en) | Cosmetic for hair | |
JP4041451B2 (en) | Hair nourishing | |
JP2005089394A (en) | Hair tonic | |
JPH08157337A (en) | Hair cosmetic | |
JP3808417B2 (en) | Hair nourishing | |
JP2005200357A (en) | Hair-fostering cosmetic | |
JP2005089393A (en) | Hair tonic | |
JP4577596B2 (en) | Hair restorer or hair growth agent and method of use thereof | |
JP3190487B2 (en) | Anti-dandruff hair cosmetics and hair nourishes | |
JP3542700B2 (en) | Head composition | |
JP4495900B2 (en) | Hair nourishing | |
JP2005213143A (en) | Hair papilla cell proliferation enhancer and hair nourisher | |
JPH10158124A (en) | Trichogen | |
JP2003012468A (en) | Promoter for restoration and growth of hair |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20050615 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20060328 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20060621 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20060704 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060807 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20060905 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20060906 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 3853773 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100915 Year of fee payment: 4 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100915 Year of fee payment: 4 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110915 Year of fee payment: 5 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120915 Year of fee payment: 6 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130915 Year of fee payment: 7 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
EXPY | Cancellation because of completion of term |