JPH10158124A - Trichogen - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a trichogen capable of stimulating the blood circulation of scalp and activating the scalp and thereby excellent in the trichogenous effect. SOLUTION: This trichogen contains at least one kind of monoacylglyceride selected from 1-butyric acid monoglyceride, 2-butyric acid monoglyceride, 1- caproic acid monoglyceride and 2-caproic acid monoglyceride preferably in an amount of 0.001-10wt.%.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair growth / hair restoration material, and more particularly to a hair growth / growth effect by promoting and activating the blood circulation of the scalp, and having a safety that can sufficiently withstand long-term use. Hair growth and hair growth materials.

[0002]

2. Description of the Related Art Conventionally provided hair growth and hair growth products contain various crude drug extracts or various compounds. For example, crude drug extracts include extracts such as yoquinin and cashew (see Japanese Patent Publication No. 1-13451, JP-A-2-48514, etc.), and compounds such as vitamin E, alloxazine, pyridine N-oxide, and adenosine-3. ', 5'-cyclic monophosphate, odd-carbon chain-length fatty acid, etc. (JP-A-64-5660)
8, JP-A-1-261321, JP-A-2-261
No. 204406, JP-B-63-41363, etc.).

[0003]

However, the hair growth and hair growth materials provided so far include, as mentioned in the above examples,
Various herbal extracts and various compounds have been applied, but there are few that show a remarkable effect, and those that have a certain effect are difficult to use continuously due to strong irritation to the scalp. There was a problem with storage stability.

[0004] The present invention has been made in view of such circumstances, and has an excellent hair growth and hair growth effect, and has safety and stability that can sufficiently withstand long-term use.
It is an object to provide a hair growth material.

[0005]

The present inventors have conducted intensive studies to solve the above-mentioned problems. As a result, monoacylglycerin having a specific low-molecular-weight acyl group promotes blood circulation of the scalp and activates it. By doing so, they have found that they have excellent hair growth and hair growth effects, and that there are no safety problems during use, and have completed the present invention based on such findings.

That is, in the present invention, at least one kind of monoacylglycerin selected from butyric acid monoglyceride and caproic acid monoglyceride is preferably used in an amount of 0.001% or less.
The present invention relates to a hair growth and fostering agent characterized by containing 1 to 10% by weight.

Hereinafter, the present invention will be described in detail.

First, the monoacylglycerin applied to the present invention is selected from, for example, monoglyceride butyrate such as 1-butyric acid monoglyceride and 2-butyric acid monoglyceride, caproic acid monoglyceride such as 1-caproic acid monoglyceride and 2-caproic acid monoglyceride. Among them, 1-butyric acid monoglyceride, also referred to as α-monobutyrin, is most preferred from the viewpoint of hair growth and hair growth effects.

The monoacylglycerin according to the present invention is acylated using glycerin as a starting material by a conventional method, for example, using an acyl halide, and then separated by column purification or the like, or 3-chloropropylene glycol or 2-chloropropylene. It can be easily obtained by heating trimethylene glycol and fatty acid sodium.
In addition, 1-butyric acid monoglyceride and the like are
-Butyrylglycerol, which is commercially available, may be used.

[0010] Next, the content of monoacylglycerin contained as an active ingredient of the hair growth / hair restoration according to the present invention is preferably 0.001 to 10% by weight, particularly preferably 0.01% by weight.
5 to 5% by weight. If the content is less than 0.001% by weight, the hair growth / hair growth effect is reduced, and even if the amount exceeds 10% by weight, the effect is not enhanced and it is uneconomical. preferable.

When the monoacylglycerin according to the present invention is incorporated into a hair growth / hair growth material, the temperature is preferably set to 40 ° C. or lower, but the other components need not be particularly considered and can be incorporated stably. Furthermore, this substance has no concern about human toxicity and skin injury, and can be used safely.
As a compounding method, a method in which monoacylglycerin is dissolved in a small amount of ethanol and then mixed with an aqueous phase or an oil phase component is preferable.

In addition to the above-mentioned monoacylglycerin, the hair growth and hair growth preparations of the present invention also contain additives usually used for hair growth and growth hair growth, such as carpronium chloride, benzyl nicotinate, vitamin E, vitamin E acetate, and the like. Vitamin E linoleate, vitamin E nicotinate, skin peripheral vasodilators such as pepper tincture, hinokitiol, cationic surfactants, fungicides such as parabens, fresheners such as l-menthol, hydrocarbons, waxes, oils and fats, esters Kind,
Oils such as higher fatty acids and higher alcohols, and other surfactants, fragrances, pigments, antioxidants, ultraviolet protective agents, alcohols, pH adjusters, water, and the like can be added.

The hair growth and fostering agent of the present invention includes various dosage forms, for example, hair tonic, shampoo, rinse, pomade, hair lotion, hair cream, hair treatment and the like, and is prepared according to a conventional method.

[0014]

Next, the effect of the monoacylglycerin of the present invention on hair growth in mice will be described based on comparative experiments.

"Mouse Hair Growth Evaluation Test" (1) Samples Samples of the products 1 to 4 of the present invention, which are monoacylglycerins according to the present invention, and a comparative product 1 conventionally known as having a hair growth and hair growth effect. A 70% aqueous ethanol solution containing 5% of each of the sample 3 and the samples shown in Comparative Products 4 and 5, which are analogous substances of the monoacylglycerin according to the present invention, was used. In addition, 70% as a control
An aqueous ethanol solution was used.

[Specimen] Invention product 1: 1-butyric acid monoglyceride Invention product 2: 1-caproic acid monoglyceride Invention product 3: 2-butyric acid monoglyceride Invention product 4: 2-caproic acid monoglyceride Comparative product 1: Vitamin E comparative product 2: 1-propionic acid monoglyceride comparative product 3: 1-valeric acid monoglyceride comparative product 4: butyric acid triglyceride comparative product 5: caproic acid triglyceride

(2) Test method Using 8-week-old C3H mice, one group consists of 10 mice.
After making a group and removing the back of the hair to a size of 2.0 × 2.0 cm, 100 μl of each sample was applied to the hair removal site the next day.
Two weeks later, the density of hair growth at the site was evaluated as an increase in blackness (a decrease in L value) using a colorimeter. Table 1 shows the results.

[0018]

[Table 1]

As is clear from the results in Table 1, the specific monoacylglycerin according to the present invention is not only a control, but also a vitamin E which is conventionally known as a hair growth and hair growth agent.
In comparison with triglycerides which are analogous substances of monoacylglycerin according to the present invention, the L value is clearly reduced, that is, the blackness is increased, and the hair growth and hair growth effects are excellent. It was proved that there was. This is presumably because the monoacylglycerin according to the present invention stimulated hair roots, increased blood circulation around hair follicles, activated metabolism, and promoted hair growth.

[0020]

The present invention will be further described with reference to the following examples.
In addition, the compounding amount is a weight part. Examples 1-6. Hair tonic Using the components and composition shown in Table 2 below, each component was heated and dissolved, and solubilized to prepare a hair tonic.

[0021]

[Table 2]

"Human hair growth and hair growth evaluation test" (1) Sample The present invention product: hair tonic of Examples 1 to 6 Comparative product 1: 1-butyric acid monoglyceride of the hair tonic of Example 1 was converted to 1-valeric acid monoglyceride Replaced hair tonic Comparative product 2: Hair tonic of Example 1 except that 1-butyric acid monoglyceride was removed (water was increased)

(2) Test Method Eighty test subjects complaining of Japanese hair thinning and alopecia were divided into eight groups of 10 subjects each, and a long-term continuous test for 24 weeks was performed using each sample. The application method was a method of evenly applying the composition to the head twice a day as in the usual tonic usage. The evaluation was performed on the 12th week and the 24th week, and the number of test subjects who felt that the amount of downy hair and hard hair had increased was measured. At the end of the application test, the subjects were also required to report on the improvement of the condition of the scalp and the reduction of dandruff. The results are shown in Tables 3 and 4.

[0024]

[Table 3]

[0025]

[Table 4]

As is evident from the results in Table 3, the hair growth and fostering materials of the product of the present invention all show a marked increase in the number of people with naive or hard hair as compared with the hair growth and fostering material of the comparative product. And a hair growth effect was observed. In addition, as shown in the results of Table 4, in all the products of the present invention, the condition of the scalp at the end of the application test was improved, and there was a person who reported that the occurrence of dandruff was reduced. Admitted. Furthermore, no skin damage such as deterioration of the scalp condition or inflammatory reaction was observed in any of the subjects during the long-term application test, and thus it was confirmed that there was no problem in safety.

Embodiment 7 Hair tonic (A) 1-caproic acid monoglyceride 0.05 menthol 0.2 vitamin E 0.05 carpronium chloride 0.1 (B) ethanol 50.0 (C) propylene glycol 5.0 vitamin B2 0.5 yeast extract (Containing nucleic acid) 0.5 dipotassium glycyrrhizin 0.3 diphenhydramine hydrochloride 0.3 methyl paraben 0.2 (D) purified water 42.7 (E) flavor 0.1

(Preparation method) (A) was dissolved in (B), and (D) in which (C) and (E) were dissolved was added and mixed to prepare a hair tonic.

Embodiment 8 Hair treatment (A) Liquid paraffin 2.0 Methylpolysiloxane (10 cs) 2.0 Cetanol 4.0 (B) Stearyltrimethylammonium chloride 3.0 Distearyldimethylammonium chloride 0.5 Propylene glycol 5.0 Pyrocton olamine 0.25 purified water 40.0 (C) hydrolyzed collagen 0.5 hyaluronic acid 0.01 bovine placenta extract 0.5 diphenhydramine chloride 0.25 methyl paraben 0.2 purified water 38.69 1-butyric acid monoglyceride 3.0 (D) Fragrance 0.1

(Preparation method) After heating (A) and (B) to 80 ° C., both are mixed and emulsified. Thereafter, it is cooled to around 40 ° C., at which point (C) and (D)
Was added and mixed to prepare a hair treatment.

Embodiment 9 Hair Shampoo (A) Triethanolamine Lauryl Sulfate 10.0 Sodium Lauryl Sulfate 5.0 Coconut Oil Diethanolamide 2.0 Propylene Glycol 5.0 Piroctone Olamine 0.25 Benzyl Nicotinate 0.1 (B) Trichlorocarbani Lid 0.25 Purified water 75.3 (C) 2-butyric acid monoglyceride 2.0 (D) Fragrance 0.1

(Preparation method) (A) was mixed at 80 ° C.
Thereafter, the mixture was cooled to around 40 ° C., (B) and (C) were added and mixed, and (D) was further added to prepare a hair shampoo.

Embodiment 10 FIG. Hair rinse (A) Liquid paraffin 0.5 Methylpolysiloxane (10 cs) 0.5 Cetanol 2.0 Stearyltrimethylammonium chloride 3.0 (B) 1,3-butylene glycol 5.0 Purified water 40.0 Diphenhydramine hydrochloride 0.0 25 (C) Glycyrrhizin dipotassium 0.25 Purified water 47.4 1-Caproic acid monoglyceride 1.0 (D) Fragrance 0.1

(Preparation method) Each of (A) and (B) is heated to 80 ° C. and mixed and emulsified at that time. Thereafter, the mixture was cooled to about 40 ° C., (C) was added, and (D) was further added to prepare a hair rinse.

Embodiment 11 FIG. Hair cream (A) Vaseline 7.0 Beeswax 8.0 Liquid paraffin 37.0 Polyoxyethylene (20E.0) cetyl ether 3.0 Glyceryl monostearate 2.0 Vitamin E nicotinate 0.1 (B) Purified water 32.1 Propylene glycol 5.0 Diphenhydramine hydrochloride 0.2 Dipotassium glycyrrhizin 0.2 Ethyl paraben 0.3 (C) 2-Caproic acid monoglyceride 5.0 (D) Fragrance 0.1

(Preparation method) (A) was mixed and dissolved at 80 ° C., and then (B) previously heated to 80 ° C. was replaced with (A)
Was gradually added to form a cream. Thereafter, the mixture was cooled to 40 ° C., and (C) and (D) were added and mixed to prepare a hair cream.

Embodiment 12 FIG. Hair tonic (A) 1-butyric acid monoglyceride 0.5 Salicylic acid 0.3 Menthol 0.2 Pepper tincture 0.01 (B) Ethanol 60.0 (C) Glycerin 5.0 (D) Purified water 33.89 (E) Fragrance 0.1

(Preparation method) (A) was dissolved in (B), and (D) in which (C) and (E) were dissolved was added and mixed to prepare a hair tonic.

The hair growth and hair growth effects of the present invention obtained in Examples 7 to 12 were tested for hair growth and hair growth effects in the same manner as in Examples 1 to 6 or by a method similar thereto. No skin damage such as deterioration of the scalp condition and inflammatory reaction was observed at all.

[0040]

According to the present invention, it is possible to provide a hair growth and fostering material which has an excellent hair growth and fostering effect and which is free from skin disorders due to long-term continuous use and which is excellent in safety.

 ────────────────────────────────────────────────── ─── Continued on the front page (72) Inventor Michio Matsugami 560 Kashio-cho, Totsuka-ku, Yokohama-shi, Kanagawa Pref.

Claims (3)

[Claims] 1. A hair-growing / hair-growing agent comprising at least one monoacylglycerin selected from butyric acid monoglyceride and caproic acid monoglyceride. 2. The hair growth and fostering material according to claim 1, wherein the butyric acid monoglyceride is 1-butyric acid monoglyceride. 3. A monoacylglycerin content of 0.0
The hair growth and fostering material according to any one of claims 1 and 2, wherein the amount is from 0.01 to 10% by weight.